Fluxazole amide composition and preparation method thereof

Abstract

The invention relates to a fluxazole amide composition and a preparation method thereof. More specifically, the present invention relates to synergistic compositions of fluoxazole amides and methods of preparing stable and non-phytotoxic formulations, the synergistic composition comprises fluoxazole amide or an agrochemically acceptable salt thereof, an insecticide selected from diamides, at least one or more compounds selected from insecticides, fungicides and plant health additives, and an agrochemically acceptable excipient. The invention further relates to pesticidal compositions for controlling harmful pests in plants, which can be formulated, are environmentally safe, exhibit high efficacy, and act on disease resistance management or delay the development of disease resistance by employing a variety of modes of action, plant tolerance against insect pests, mites, fungal and bacterial diseases and abiotic stress is increased and the overall health and vigor of the treated plant is improved.

Description

Technical Field

[0001] The present invention relates to a fluxametamide composition and a method for preparing the same. More specifically, the present invention relates to an insecticidal composition and a method for preparing the composition, the insecticidal composition comprising a biologically active amount of fluxametamide or an agrochemically acceptable salt thereof, an insecticide selected from diamides, at least one or more compounds selected from insecticides, fungicides and / or plant health additives, and an agrochemically acceptable excipient. The present invention also relates to an insecticidal composition that increases plant tolerance to insect pests and mites, fungal and bacterial diseases, and abiotic stresses and improves the overall health and vitality of the treated plants. Background Art

[0002] Protecting crops and their produce from insect pests is important for increasing agricultural production. Every year, insects, plant pathogens and weeds destroy more than 40% of all food production. This loss occurs despite the application of pesticides and the use of a wide range of non-chemical controls such as crop rotation and biological controls. If just a portion of this food could be saved, it could feed more than 3 billion malnourished people in the world.

[0003] The problem of insecticide resistance in agricultural production is a global problem and has always been the focus of attention of agricultural science and technology workers. Chemical control through the use of various chemicals and preparations is an important means of preventing and controlling pests in agriculture. Many types and groups of insecticides have been reported in the literature, and a large number of insecticides are used commercially to control pests in agriculture. With the continuous use of chemical insecticides for pest control year by year, the use of insecticides has increased, and the use of insecticides is unscientific; the resistance of pests has become more and more serious, and the number of pests that develop resistance has increased. At the same time, the high-intensity use of insecticides has led to a series of problems such as excessive pesticide residues in agricultural products, environmental pollution, and increased drug costs for farmers, which is not conducive to the sustainable development of agriculture.

[0004] The history of the insecticide isoxazolines dates back to the discovery of phthalamide and anthranilic diamide. The isoxazolines target the γ-aminobutyric acid (GABA) receptors of the chloride channel, and the diamides target the ryanodine receptor (RyR) of the calcium-activated calcium channel. The phthalamide flubendiamide and the anthranilic diamides chlorantraniliprole and cyantraniliprole act at the allosteric site of the RyR, activating calcium release in insects (but not in mammals). They are the most important insecticide introductions of the past two decades. Insecticide researchers at Nihon Nohyaku, Japan, developed flubendiamide, the first diamide insecticide, from a pyrazine dicarboxamide herbicide with weak insecticidal activity. The key step was the introduction of an aniline moiety with a perfluoroalkyl side chain. These developments took place between 1993 and 2006. During this period, DuPont researchers discovered highly effective o-formamidobenzamides, which were first optimized to chlorantraniliprole and then to cyantraniliprole. Phthalamide and o-formamidobenzamide are very effective, have low toxicity to mammals, and act on the diamide binding site of insects (which is of little or no importance in mammals). This selectivity is a significant feature of these diamides, which are less toxic to mammals than Ry itself and bind to mammalian muscle membranes little or not at all. They are particularly effective against lepidopteran pests of cruciferous vegetable crops (e.g., Plutellaxylostella, Diamondback borer).

[0005] Agricultural biostimulants are blends of compounds, substances and microorganisms that are sprayed on plants or soil to improve the vigor, yield, quality and tolerance of crops to abiotic stresses. Biostimulants promote plant growth and development in a variety of ways throughout the crop life cycle, from seed germination to maturity. Biostimulants work through different mechanisms than fertilizers, regardless of the presence of nutrients in the product. Biostimulants are different from crop protection products because they work best on the vigor of plants without any direct effect on pests or diseases. Therefore, crop biostimulation is a supplement to crop nutrition and crop protection. Plant growth regulators are defined as small and simple chemicals produced naturally by plants to regulate their growth and development. Plant growth regulators (PGRs) are molecules that affect plant development and are usually active at very low concentrations. There are natural regulators produced by the plants themselves, as well as synthetic regulators; those found naturally in plants are called phytohormones or plant hormones.

[0006] Combinations of insecticides and fungicides are used to expand the spectrum of control of insects and fungi to improve pest control through synergistic effects, reduce dosage and thus reduce environmental impact, expand the spectrum of control i.e. control chewing and sucking insects and fungal diseases at one time, reduce the possibility of resistance development, and enhance residual control, thereby reducing the number of spraying for crop protection and minimizing the pesticide load on the ecosystem.

[0007] There are many combinations of insecticides with other insecticides or fungicides known in the art for controlling pests. For example, CN107593723A relates to a binary composition comprising fluconazolamide and chlorfenapyr, chlorpheniridine, GF-2877, spiropidion, kappa-bifenthrin, kappa-tefluthrin, cyanocastrobin, fluconazolamide, fluacloxacin, mefentrifluconazole, ipfentrifluconazole, dipymetitrone, fenpicoxamid, aminopyrifen, inpyrfluxam, trifluoromide amide, or a combination of more than one.

[0008] CN110199999A relates to a binary insecticide composition, which contains fluazifop-butyl and tolfenpyrad, wherein the weight ratio of fluazifop-butyl to tolfenpyrad is 10:1 to 1:5. The composition comprises an active ingredient and a balance of adjuvants.

[0009] WO 2018 / 224914 A1 relates to a diamide insecticide in combination with at least one multi-site fungicide and at least one second fungicide active compound. IN 201731033800 A relates to a combination comprising a diamide insecticide in combination with a fungicide active compound and a plant health promoter for controlling harmful animal pests (e.g., insects, mites and / or nematodes) and harmful plant pathogens.

[0010] However, these combinations need to be improved. Long-term use of single active combinations has led to resistance. As some pests begin to develop resistance, there is a need in the art for active substance combinations that reduce the likelihood of resistance and improve the spectrum of control of diseases and pests.

[0011] The active ingredients known from the literature have certain disadvantages, such as insufficient control efficacy, restrictions on their use due to the emergence of resistant pathogenic bacteria, phytotoxicity and pollution to plants, or toxicity to humans, livestock, fish, etc. Therefore, there is a long-standing need to develop novel and effective insecticidal combinations for controlling harmful pests in plants, which exhibit high efficacy, are safe for the environment and can be advantageously formulated.

[0012] The insecticides currently in use are not as effective; due to long-term abuse and unwise use, some pests have developed resistance to such commonly used insecticides. Therefore, their use has become increasingly difficult. Summary of the invention

[0013] Therefore, there is an urgent need to develop new methods and formulations to control these harmful pests. Therefore, it is necessary to provide an insecticidal composition that overcomes some of the existing problems and can be easily prepared without requiring a very complicated manufacturing process. The inventors have unexpectedly developed an effective insecticidal combination that improves the above-mentioned shortcomings of the prior art.

[0014] Purpose of the invention

[0015] The main purpose of the present invention is to provide a fluoxathiocarbamide composition and a preparation method thereof.

[0016] Another object of the present invention is to provide a fluoxetine amide composition and a preparation method thereof, wherein the fluoxetine amide composition comprises a biologically active amount of fluoxetine amide or an agrochemically acceptable salt thereof, a pesticide selected from diamides, at least one or more compounds selected from pesticides, fungicides and / or plant health additives, and an agrochemically acceptable excipient, and exhibits a synergistic effect.

[0017] Another object of the present invention is to provide a fluazifop-butyl composition for controlling harmful pests in plants.

[0018] Yet another object of the present invention is to provide a fluoxathiazide composition showing high efficacy, which provides comprehensive protection to crop plants against insect pests, mites, fungal and bacterial diseases.

[0019] It is a further object of the present invention to provide a fluoxetine composition that manages disease resistance or delays the development of disease resistance by employing multiple modes of action.

[0020] It is a further object of the present invention to provide fluoxetine compositions that improve the overall health, yield and vigor of treated plants.

[0021] Yet another object of the present invention is to provide a fluoxetine composition having improved plant tolerance against insect pests, mites, fungal and bacterial diseases and abiotic stresses.

[0022] A further object of the present invention is to provide a method for preparing a stable and non-phytotoxic formulation.

[0023] It is a further object of the present invention to provide a fluoxathiocarbamide composition which can be easily formulated.

[0024] A further object of the present invention is to provide a fluoxathiazolamide composition which is environmentally safe.

[0025] Summary of the Invention

[0026] The present invention provides a synergistic insecticidal composition, which comprises a biologically active amount of (A) fluoxetine amide or an agrochemically acceptable salt thereof, (B) an insecticide selected from diamides, (C) at least one or more compounds selected from insecticides, fungicides and plant health additives, and an agrochemically acceptable excipient.

[0027] The formulation of the insecticide composition is selected from capsule suspension (CS), dispersible concentrate (DC), emulsifiable concentrate (EC), water-in-oil emulsion (EO), oil-in-water emulsion (EW), Jambo ball or bag (bag in water-soluble bag), microemulsion (ME), oil dispersion (OD), oil miscible flowable concentrate (Oil miscible suspension, OF), oil miscible liquid (Oil miscible liquid, OL), suspension concentrate (SC), suspo-emulsion (SE), soluble concentrate (SL), water dispersible granule (WG or WDG), water soluble granule (SG), water soluble powder (Water soluble powder (SP), wettable powder (WP), mixed preparation of CS and SC (ZC), mixed preparation of CS and SE (ZE), mixed preparation of CS and EW (ZW), granule (GR) / soil applied granule (SAG) and controlled release granule (CR).

[0028] The composition of the present invention is in the form of an oil dispersion (OD), a suspension concentrate (SC), a suspoemulsion (SE), a water dispersible granule (WG or WDG), and a mixed preparation of a capsule suspension CS and SC (ZC).

[0029] The present invention can be formulated to be environmentally safe for the control of harmful pests in plants, showing high efficacy, acting on disease resistance management or delaying the development of disease resistance by employing multiple modes of action, increasing plant tolerance to insect pests and mites, fungal and bacterial diseases and abiotic stresses, and improving the overall health and vigor of treated plants. DETAILED DESCRIPTION

[0030] Before describing the present invention in detail, it should be understood that the present invention is not limited to the details of the parts shown in its application. The present invention can have other embodiments as described above and can be practiced or implemented in various ways. It should be understood that the wording and terminology used in this article are for description and not limitation. The present invention can have various embodiments, which can be implemented as described in the following pages of the complete specification.

[0031] The terms and words used in the following description are not limited to the bibliographical meanings, but are only used by the inventor to enable the present invention to be clearly and consistently understood. Therefore, it should be apparent to those skilled in the art that the following description of the exemplary embodiments of the present invention is provided only for the purpose of illustration, rather than for the purpose of limiting the scope of the present invention.

[0032] It is to be understood that the singular forms "a," "an," and "the" include plural references unless the context clearly dictates otherwise.

[0033] Features described and / or illustrated with respect to one embodiment may be used in the same or similar manner in one or more other embodiments and / or in combination with or in place of features of other embodiments.

[0034] It should be emphasized that the term "include / comprises" when used in this specification is used to illustrate the existence of the described features, steps or components, but does not exclude the existence or addition of one or more other features, steps, components or combinations thereof.

[0035] The term "plant" as used herein refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, branches, leaves and fruits. The term "plant" is understood to include wild-type plants and plants that have been improved by conventional breeding or mutation formation or genetic engineering or a combination thereof.

[0036] The term "crop" refers to both growing crops and harvested crops.

[0037] As used herein, the term "insect" includes all organisms in the class "Insecta".

[0038] The term "animal pest" includes arthropods, gastropods and nematodes. Preferred animal pests according to the present invention are arthropods, preferably insects and arachnids, especially insects. Insects that are particularly associated with crops are generally referred to as crop insect pests.

[0039] As used herein, the term "insecticide" refers to the ability of a pesticide to increase the mortality rate or inhibit the growth rate of a pest.

[0040] "Controlling" or "inhibiting" pests means inhibiting the ability of pests to survive, grow, feed and / or reproduce, or limiting pest-related damage or losses in crop plants by toxic effects. "Controlling" pests may or may not mean killing the pests, although preferably it means killing the pests.

[0041] The term "plant health" or "plant health" is defined as the condition of a plant and / or its products. As a result of improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stresses are increased.

[0042] "Yield" is to be understood as any economically valuable plant product produced by a plant, such as cereals, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of afforestation plants) or even flowers (e.g. in the case of horticultural plants, ornamental plants).

[0043] "Increased yield" of plants, especially agricultural, silvicultural and / or horticultural plants, means that the yield of a product of the corresponding plant is increased by a measurable amount compared to the yield of the same product produced by the plant under the same conditions but without application of the composition of the invention.

[0044] The present invention provides a synergistic insecticidal composition comprising

[0045] 1. Compound A - oxazolidinone or its agrochemically acceptable salt,

[0046] 2. Compound B - an insecticide selected from the class of diamides,

[0047] 3. Compound C—at least one or more compounds selected from pesticides, fungicides and / or plant health additives,

[0048] The mass percentages of the compositions are as follows:

[0049] Serial number Element Concentration range (w / w%) 1. Compound A 1 to 20 2. Compound B 1 to 20 3. Compound C 0.001 to 60

[0050] Fluoxazolamide, 4-((5RS)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazol-3-yl)-N-((EZ)-(methoxyimino)methyl)-o-toluamide is a new broad-spectrum insecticide discovered and synthesized by Nissan Chemical Industries, Ltd. It belongs to a class of compounds known as isoxazolines, which are potent inhibitors of gamma-aminobutyric acid (GABA)-gated chloride channels, glutamate-gated chloride channels, and glycine-gated chloride channels in insects.

[0051]

[0052] Fluoxathiazide is a broad-spectrum isoxazoline insecticide that is effective against a variety of pests. It is mainly used to control lepidopteran insect pests, thrips, whiteflies, leafminers, beetles and mites on crops such as fruit trees, vegetables, soybeans, cotton and tea trees.

[0053] Compound B includes an insecticide selected from the diamide class of chlorantraniliprole, cyantraniliprole, cyclobromofenamide, tetrazolyl thiocarb, tetrazolyl thiocarb, tyclopyrazoflor, cyhalodiamide, fluchlordiniliprole, fluchlordiniliprole and tiorantraniliprole.

[0054] More specifically, compound B is selected from chlorantraniliprole, cyantraniliprole, tetrazobactam and flubendiamide.

[0055] The carbamate insecticide (AChE-acetylcholinesterase inhibitor) used for compound C is selected from carbaryl, carbofuran, carbosulfan, methomyl, oxamyl, pirimicarb and thiodicarb; the organophosphate insecticide (AChE-acetylcholinesterase inhibitor) is selected from acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, Methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos and triazophos; phenylpyrazoles-fiproles (GABA-gated chloride channel blockers) selected from ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole and pyriprole;Pyrethroid insecticides (sodium channel modulators) are selected from bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, -cypermethrin), theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallemethrin thrin), profluthrin and pyrethrin (pyrethrum); nicotinic insecticides (competitive modulators of nicotinic acetylcholine receptors (nAChR)) selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, Flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin, sulfonimides (sulfoxaflor), butenolides (flupyradifurone), meso-ions (triflumezopyrim, dichloromezotiaz and fenmezoditiaz);Nereistoxin analog insecticides (nicotinic acetylcholine receptor (nAChR) channel blockers) selected from bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride and thiosultap sodium); spinosyn insecticides (nicotinic acetylcholine receptor (nAChR) allosteric modulators - site I) selected from spinosad and spinetoram; avermectin and milbemycin insecticides (glutamate-gated chloride channel (GluCl) allosteric modulators) selected from avermectins (abamectin, emamectin benzoate, benzoate, ivermectin, lepimectin and milbemycins (milbemectin); biomimetic juvenile hormone insecticides selected from hydroprene, kinoprene, methoprene, fenoxycarb and pyriproxyfen; non-specific multi-site inhibitor insecticides selected from chloropicrin , dazomet and metam; the chord organ modulator insecticide is selected from pymetrozine, pyrifluquinazon, afidopyropen and flonicamid; the CHSI-affecting mite growth inhibitor insecticide is selected from clofentezine, hexythiazox, diflovidazin or etoxazole;The benzoylurea insecticide (inhibitor of chitin biosynthesis affecting CHSI) is selected from bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron; the thiazolinone insecticide (inhibitor of chitin biosynthesis type 1) is selected from thiazolinone; the cyromazine insecticide (molting disruptor for dipteran insects) is selected from cyromazine; the insecticide of microbial disruptors of insect midgut membrane is selected from Bacillus thuringiensis. thuringiensis and the insecticidal proteins produced by them; the uncoupler class insecticides of oxidative phosphorylation are selected from chlorfenapyr, DNOC or sulfluramid; the dihydrazide insecticides (ecdysone receptor agonists) are selected from the dihydrazide methoxyfenozide, tebufenozide, halofenozide, fufenozide or chromafenozide; the octopamine receptor agonists are selected from the octopamine receptor agonists. The mitochondrial ATP synthase inhibitor is selected from diafenthiuron, azocyclotin, cyhexatin, fenbutatinoxide, propargite or tetradifon; the METI (mitochondrial complex I) inhibitor is selected from fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim and pyriminostrobin; METI (mitochondrial complex II) inhibitor insecticides selected from cyenopyrafen, cyflumetofen and pyflubumide;The METI (mitochondrial complex III) inhibitor insecticide is selected from hydramethylnon, acequinocyl, fluacrypyrim, bifenazate and flometoquin; the METI (mitochondrial complex IV) inhibitor insecticide is selected from phosphides and cyanides; the voltage-dependent sodium channel blocker insecticide is selected from indoxacarb and metaflumizone; the lipid synthesis inhibitor The inhibitor (inhibitor of acetyl CoA carboxylase) class insecticide is selected from spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion or spirobudifen; the baculovirus class insecticide is selected from granulovirus and nucleopolyhedrosis virus. virus; calcium-activated potassium channel (KCa2) modulator insecticides selected from acynonapyr; compounds with unknown or uncertain mode of action selected from azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, acaricide compounds fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen and trifluenfuronate. ;

[0056] More specifically, the insecticide used for compound C is selected from avermectin, avermectin benzoate, tolfenpyrad, pyrifoquinoxaline, lambda cyhalothrin, fipronil, fenpyroximate, hexythiazox, etoxazole, diafenthiuron, methoxyfenozide, spinosad, indoxacarb, biprofenopyr, flonicamid, pyriproxyfen, bifenthrin, deltamethrin, thiamethoxam and dinotefuran.

[0057] The fungicide of the nucleic acid synthesis inhibitor group for compound C is selected from benalaxyl, benalaxyl-M, furalaxyl, metalaxyl, metalaxyl-M, ofurace, oxadixyl, bupirimate, dimethirimol, ethirimol, octhilinone, hymexazole, oxolinic acid, acid), 5-fluorocytosine, 4-amine and 5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4-amine; the fungicide of the cytoskeleton and motor protein / cell division inhibitor group is selected from benomyl, carbendazim, fuberidazole, thiabendazole, thiophanate, thiophanate-methyl, diethofencarb, zoxamide, ethaboxam, pencycuron, fluopicolide, flufenoxadiazam, fluopimomide, phenamacril, metrafenone and pyriofenone;The fungicide of the SDHI (succinate dehydrogenase inhibitor) group is selected from benodanil, flutolanil, mepronil, isofetamido, fluopyram, fenfuram, carboxin, oxycarboxin, thifluzamide, benzovindiflupyr, bixafen, fluindapyr, fluxapyramide, xad), furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, flubeneteram, pyrapropoyne, inpyrfluxam, isoflurane, pydiflumetofen, boscalid, and pyraziflumid; QoI-fungicides (Quinone The fungicide of the group of outside Inhibitor) is selected from pyribencarb, fluoxastrobin, fenamidone, mandestrobin, azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, famoxadone, dimoxystrobin, fenamistrobin, metominostrobin, orysastrobin, kresoxim methyl and trifloxystrobin;The fungicide of the QiI-fungicide (Quinone inside inhibitor) group is selected from cyazofamid, amisulbrom, fenpicoxamid, florylpicoxamid, metaylpicoxamid and metyltetraprole; the fungicide of the uncoupler group of oxidative phosphorylation is selected from binapacryl, meptyldinocap, dinocap and fluazinam; the fungicide of the inhibitor group of oxidative phosphorylation and ATP synthase is selected from fentin acetate, fentin chloride and fentin hydroxide. hydroxide; the fungicide of the group of inhibitors of ATP transport is selected from silthiofam; the fungicide of the quinone external inhibitor stigmatellin combination (QoSI) is selected from ametoctradin; the fungicide of the group of inhibitors of amino acid and protein synthesis is selected from cyprodinil, mepanipyrim, pyrimethanil, blasticidin-S, kasugamycin, streptomycin and oxytetracycline; the fungicide of the group of signal transduction inhibitors is selected from quinoxyfen, proquinazid, fenpiclonil, fludioxonil, chlozolinate, dimethachlone, iprodione, procymidone and vinclozolin;The fungicide of the lipid or transport and membrane synthesis inhibitor group is selected from isoprothiolane, edifenphos, iprobenfos (IBP), pyrazophos, biphenyl, chloroneb, dicloran, quintozene, tecnazene, tolcofos-methyl methyl), etridiazole, iodocarb, propamocarb, prothiocarb, Melaleuca arternifolia (tea tree) extract, vegetable oil (mixture), eugenol, geraniol, thymol, natamycin (pimaricin), oxathiapipronil, fluoxapipronil, and fluoxapiprolin-S;The fungicide of the sterol biosynthesis inhibitor group is selected from imazalil, oxpoconazole, pefurazoate, procloraz, triflumizole, triforine of the piperazine class, pyrifenox, pyrisoxazole of the pyridine class, fenarimo, naurimol of the pyrimidine class, azaconazole, bitertanol, and fenthiocarbamide of the triazole class. bromuconazole), cyproconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, frutriafol, hexaconazole, imibenconazole, ipconazole conazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, simconazole, tebuconazole, tetraconazole, tiradimefon, tiradimenol, triticonazole, fluoxytioconazole, aldimoprh, dedomorph, tridemorph, fenpropimorph, fenpropidin, piperalin, spiroxamine, fenpyrazamine, fenhexamid, naftifine, terbinafine, and pyributicarb;The fungicide of the cell wall biosynthesis inhibitor group is selected from polyoxin, dimethomorph, flumorph, pyrimorph, mandipropamid, benthiavalicard, iprovalicarb and alifenalate; the fungicide of the cell wall melanin synthesis inhibitor group is selected from fthalide, pyroquilon, tricyclazole, diclycymet, carpropamid, fenoxanil and tolprocarb; the fungicide of the plant defense inducer group is selected from acibenzolar-S-methyl, probenazole, tiadinil, isotianil, laminarin, Reynoutria sachalinensis, giant knotweed knowweed extract, Bacillus mycoides isolate J of the bacterium Bacillus, cell wall of Saccharomyces cerevisiae strain LAS117, fosetyl-AL and phosphoric acid and salts; fungicides of the unknown mode of action group are selected from cymoxanil, teclofthalam, triazoxide, fluslfamide, diclomezine, cyflufenamid, dodine, flutianil, ferimzone, tebufloquin, picarbutrazox and validamycin; fungicides of the unclassified (N) group are selected from mineral oil, inorganic oil, organic oil, potassium bicarbonate and biogenic materials;The fungicide from the chemical group with multi-site contact activity is selected from copper (copper hydroxide, copper oxychloride, copper (II) sulfate, bordeaux mixture, copper salicylate, copper oxide), sulfates, ferbam, mancozeb, maneb, metiram, propineb, thiram, zinc thiazole, thiazole, zineb, ziram, captan, captafol, folpet, chlorothalonil, dichlofluanid, guazatine, iminoctadine, anilazine, dithianon, chinomethionat / quinomethionate, fluoroimide and methasulfocarb from the phthalimide class; fungicides from the group of biological agents (BM) with multiple modes of action selected from the group consisting of cotyledon extract of lupine plantlet ("BLAD"), plant extracts of phenols, sesquiterpenes, triterpenes, coumarins, microorganisms (live microorganisms or extracted metabolites: Trichoderma atroviride strain SC1, dark green Trichoderma strain I-1237, dark green Trichoderma strain LU132, Trichoderma asperellum strain T34, Gliocladium catenulatum strain J1446, Clonostachys rosea strain CR-7, Bacillus amyloliquefaciens strain QST713, strain FZB24, strain MBI600, strain D747, strain F727, Bacillus subtilis strain AFS032321, Pseudomonas chlororaphis strain AFS009, Streptomyces griseovirides strain K61, Streptomyces lydicus strain WYEC108, and Polyoxin D zinc salt (Polyoxin D zinc salt) were used as the raw materials. D zinc salt);Other groups of fungicides are selected from ipflufenoquin, pyridachlometyl, quinofumelin, dichlobentiazox, aminopyrifen, dipymetitrone, seboctylamine (bactericides) and chloroinconazide (viricides). ;

[0058] More specifically, the fungicide used for compound C is selected from pyraclostrobin, fluopyraclostrobin, azoxystrobin and difenoconazole.

[0059] The plant health additives of the biostimulant group of compound C are selected from humic acid and salts, fulvic acid and salts, amino acids (alanine, arginine, aspartic acid, cysteine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine or mixtures thereof), protein hydrolyzates, carboxylic acids, jasmonic acid, methyl jasmonate, chitosan, chitin, alginate, cyclodextrin, thiabendazole, acibenzolar-S-methyl, laminarin, seaweed extracts (Ascophyllum nodosum nodosum), polyamines, silicic acid and salts - orthosilicic acid (H4SiO4), salicylic acid, lactic acid, phenyllactic acid, fumaric acid, nitrobenzene, stigmasterol, campesterol, brassinolide (homo), forchlorfenuron, triacontanol, nitrophenolates (sodium p-nitrophenolate, o-nitrophenolate, sodium-5-nitroguaiacolate) or mixtures thereof; plant health additives from the group of plant growth promoters / regulators selected from limanarin, indoleacetic acid, indolebutyric acid, α-naphthylacetic acid, kinetin, zeatin, 6-benzylaminopurine, 6-benzyladenine, dipheylurea, thidiazuron, anisiflupurin, aviglycine, prohexadione, prohexadione calcium (prohexadione calcium), trinexapac, trinexapac-ethyl, aminoethoxyethyleneglycine (AVG), gibberelline, gibberellic acid, GA3, abscisic acid, chlorpropham, flumetralin, maleic hydrazide, mepiquat, mepiquat chloride, mepiquat pentaborate, chlormequat, chlormequat chloride, paclobutrazol, uniconazole-P or a mixture thereof;The plant health additives of the micronutrient group are selected from zinc (zinc sulfate heptahydrate, zinc sulfate monohydrate, Zn-EDTA, zinc oxide, zinc lactate gluconate, zinc polyflavonoid), ferrous sulfate, copper sulfate, manganese sulfate, boron (borax-sodium tetraborate, boric acid (H3BO3), disodium octaborate tetrahydrate (Na2B8O; 13 .4H2O), disodium tetraborate pentahydrate, anhydrous borax, mepiquate chloride and sulfur (elemental sulfur, bentonite sulphur, borated sulfur or sulfates and thiosulfates) or mixtures thereof.

[0060] More specifically, the plant health additive for compound C is selected from zinc oxide, campesterol, ascophyllum nodosum, salicylic acid, orthosilicic acid, limanarin, amino acids, fulvic acid, humic acid, gibberellin, mepiquat, paclobutrazol and stigmasterol. The amino acid for compound C is glycine.

[0061] The present invention also optionally includes agrochemically acceptable excipients, including but not limited to dispersants, antifreeze agents, defoamers, wetting agents, suspension aids and carriers, antimicrobial agents, thickeners, colorants, quick coating agents or stickers (also called "fixatives" or "binders"), polymers, disintegrants, oil additives, buffers and solvents.

[0062] The surfactant used as a dispersant has the ability to strongly adsorb on the surface of the particles and provides a charged or spatial barrier for particle reaggregation. The most commonly used surfactants are anionic surfactants, nonionic surfactants, or mixtures of these two types. For wettable powder formulations, the most common dispersant is sodium lignin sulfonate. For suspension concentrates, polyelectrolytes (such as sodium naphthalene sulfonate formaldehyde condensates) are used to obtain very good adsorption and stability. Tristyryl phenol ethoxylate phosphate ester is also used. Nonionic surfactants such as alkyl aryl ethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionic surfactants as dispersants for suspension concentrates. In recent years, new types of extremely high molecular weight polymer surfactants have been developed as dispersants. These polymer surfactants have very long hydrophobic "main chains" and a large number of ethylene oxide chains that form the "teeth" of "comb-like" surfactants. These high molecular weight polymers can provide very good long term stability for suspension concentrates because the hydrophobic backbone has many anchoring points to the particle surface. Dispersants used herein include, but are not limited to, sodium lignin sulfonate, sodium naphthalene sulfonate formaldehyde condensate, tristyrylphenol ethoxylate phosphate, fatty alcohol ethoxylate, alkyl ethoxylate, EO-PO block copolymer, graft copolymer or mixtures thereof.

[0063] The cryoprotectant used herein may be selected from polyethylene glycol, methoxypolyethylene glycol, polypropylene glycol, polybutylene glycol, glycerol and ethylene glycol.

[0064] Water-based formulations often cause foaming during the mixing operation of production. In order to reduce the tendency to foam, defoamers are usually added during the production stage or before filling into the bottle. Generally speaking, there are two types of defoamers, silicone and non-silicone. Silicones are usually aqueous emulsions of dimethyl polysiloxane, while non-silicone defoamers are water-insoluble oils (such as octanol and nonanol) or silica. In both cases, the role of the defoamer is to displace the surfactant from the air-water interface.

[0065] Wetting agents used in wettable powder, suspension concentrate and water dispersible granule formulations include, but are not limited to, sodium lauryl sulfate, sodium dioctyl sulpho-succinate, alkylphenol ethoxylates, fatty alcohol ethoxylates or mixtures thereof.

[0066] Suspension aids refer to natural or synthetic organic or inorganic materials that are combined with active substances to facilitate their application to plants, seeds or soil. It is usually inert and must be agriculturally acceptable, especially acceptable to the plants to be treated. The carrier can be solid and is selected from, but not limited to, diatomaceous earth, attapulgite or zeolite, dolomite, silica, fly ash, slaked lime, wheat flour, wood flour, ground wheat straw, cellulose and soy flour, bentonite, kaolin, calcium carbonate, talc, muscovite, fused sodium potassium, aluminum silicate, perlite, urea, sulfur-coated urea, isobutylidene diurea, ammonium nitrate, ammonium sulfate, ammonium phosphate, triple superphosphate, phosphate), phosphoric acid, potassium sulfate, potassium nitrate, potassium metaphosphate, potassium chloride, dipotassium carbonate, potassium oxide and combinations of these substances; alternatively, the carrier can be a liquid and is selected from, but not limited to, water, toluene, xylene, petroleum ether, vegetable oil, acetone, methyl ethyl ketone, cyclohexanone, acid anhydride, acetonitrile, acetophenone, amyl acetate, 2-butanone, butylene carbonate, chlorobenzene, cyclohexane, cyclohexanol, alkyl acetate, diacetone alcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol rosin acid ester, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N,N-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, di Propylene glycol (diproxitol), alkyl pyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 1,1,1-trichloroethane, 2-heptanone, α-pinene, d-limonene, ethyl lactate, ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, γ-butyrolactone, glycerol, acetic acid glyceryl, diacetic acid glyceryl, triacetic acid glyceryl, hexadecane, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropyl benzene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxypropanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl octanoate, methyl oleate, dichloromethane, m-xylene, n-hexane, n-octylamine, octadecanoic acid, octylamine acetate acetate), oleic acid, oleylamine, o-xylene, phenol, polyethylene glycol, propionic acid, propyl lactate, propylene carbonate, propylene glycol, propylene glycol methyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylene sulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, methanol, ethanol, isopropanol and higher molecular weight alcohols (e.g., amyl alcohol, tetrahydrofurfuryl alcohol, hexanol, octanol, ethylene glycol, propylene glycol, glycerol), N-methyl-2-pyrrolidone, and the like.

[0067] Biocides / microorganisms can cause the formulation to deteriorate. Therefore, antimicrobial agents are used to eliminate or reduce their effects. Such agents include, but are not limited to, propionic acid and its sodium salts, sorbic acid and its sodium or potassium salts, benzoic acid and its sodium salts, p-hydroxybenzoic acid sodium salts, methyl parahydroxybenzoate, and biocides such as sodium benzoate, 1,2-benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isoxazolin-3-one, potassium sorbate, parahydroxybenzoates, or mixtures thereof.

[0068] Thickeners, gelling agents and anti-settling agents are generally divided into two categories, i.e. water-insoluble particles and water-soluble polymers. Clay and silicon dioxide (such as but not limited to montmorillonite (such as bentonite), magnesium aluminum silicate and attapulgite) can be used to produce suspension concentrate formulations. Water-soluble polysaccharides have been used for many years as thickening-gelling agents. The most commonly used polysaccharide types are natural extracts of seeds and seaweed, synthetic derivatives of cellulose or mixtures thereof, such as but not limited to guar gum, locust bean gum, carrageenan, xanthan gum, alginate, methylcellulose, sodium carboxymethylcellulose (SCMC), hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starch, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures.

[0069] Suitable colorants are selected from crystal violet, thalocyano dyes, aerosol green FFB dyes, rhodamine, azo compounds, iron oxide, titanium oxide, ferric ferrocyanide, alizarin and phthalocyanine colorants.

[0070] The fast coating agent can be a conventionally available adhesive, such as polyester, polyamide, polycarbonate, polyurea and polyurethane, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinyl alcohol, vinyl acetate and vinyl pyrrolidone polymers and copolymers, polyethers, epoxy resins, phenolic resins and melamine resins, polyolefins, and their copolymers and mixtures are defined. The polymer is selected from acrylate polymers (e.g., poly(methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate)), acrylate copolymers and styrene-acrylic copolymers, poly(styrene-to-maleic anhydride), cellulose polymers (e.g., ethyl cellulose, cellulose acetate, cellulose acetate butyrate), acetylated monoglycerides, acetylated diglycerides and acetylated triglycerides, poly(vinyl pyrrolidone), vinyl acetate polymers and copolymers, poly(ethylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more thereof. Biodegradable polymers can also be used in the present invention. As used herein, a polymer is biodegradable, even if it is insoluble in water, but will degrade after being placed in the application environment for several weeks. The biodegradable polymer is selected from biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly (lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly (n-pentyl methacrylate), wood resins, polyanhydrides, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters, polyhydroxybutyrates, or mixtures thereof.

[0071] Biodegradable polymers can also be used in the present invention. As used herein, polymers are biodegradable, even if insoluble in water, but placed in an application environment and degraded over a period of several weeks. Biodegradable polymers are selected from starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly(n-pentyl methacrylate), wood resins, polyanhydrides, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters, polyhydroxybutyrate or its mixture.

[0072] The disintegrant is selected from, but not limited to, citric acid, succinic acid or sodium bicarbonate.

[0073] The oil additive is selected from oils of vegetable origin (such as rapeseed oil, olive oil or sunflower oil), emulsified vegetable oils or oils of animal origin (such as fish oil or tallow), C8-C 22 Alkyl esters of fatty acids (e.g.12 -C 18 Methyl derivatives of fatty acids, for example the methyl esters of lauric acid, palmitic acid and oleic acid (methyl laurate, methyl palmitate and methyl oleate, respectively).

[0074] The buffer used herein is selected from calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphate, carbonated calcium phosphate, amine monomers, lactate dehydrogenase and magnesium hydroxide.

[0075] The solvent used for the preparation of the present invention is selected from but not limited to water, water-soluble alcohol and dihydroxy alcohol ether. The water-soluble alcohol that can be used for the present invention is selected from lower alcohol or water-soluble macromolecular alcohol. The term "lower alcohol" used in this article means an alcohol with 1 to 4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol. There is no restriction on macromolecular alcohol, as long as it can be dissolved in water with a suitable amount range, such as polyethylene glycol, sorbitol, glucitol. The suitable dihydroxy alcohol ether used in the present invention is selected from dihydroxy alcohol alkyl ether or dihydroxy alcohol aryl ether. Dihydroxy alcohol alkyl ether includes ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether and dipropylene glycol ethyl ether. Dihydroxy alcohol aryl ether includes ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, etc. Any solvent described above can be used alone or in combination.

[0076] However, those skilled in the art will appreciate that other agrochemically acceptable excipients may be used without departing from the scope of the present invention.The agrochemically acceptable excipient may range from 0.1% to 99% of the total weight of the composition.

[0077] The application rate of the composition according to the invention will depend on various factors, such as the object of treatment (e.g., plant, soil or seed), the type of treatment (e.g., spraying, dusting or seed dressing), the purpose of treatment (e.g., preventive or curative disease control), the type of fungus to be controlled in the case of disease control, or the time of application. Such application rates of the combination of the invention can be easily deduced by an agricultural technician.

[0078] The combination of the present invention is formulated in a manner suitable for a specific application. The formulation is selected from capsule suspensions (CS), dispersible concentrates (DC), emulsifiable concentrates (EC), water-in-oil emulsions (EO), oil-in-water emulsions (EW), Jambo balls or bags (bags in water-soluble bags), microemulsions (ME), oil dispersants (OD), oil-miscible flowable concentrates (oil-miscible suspensions (OF)), oil-miscible liquids (OL), suspension concentrates (SC), suspoemulsions (SE), soluble concentrates (SL), water-dispersible granules (WG or WDG), water-soluble granules (SG), water-soluble powders (SP), wettable powders (WP), mixed formulations of CS and SC (ZC), mixed formulations of CS and SE (ZE), mixed formulations of CS and EW (ZW), granules (GR) / soil-applied granules (SAG), controlled-release granules (CR).

[0079] More specifically, the formulation is selected from oil dispersion (OD), suspension concentrate (SC), mixed formulation of capsule suspension CS and SC (ZC), suspoemulsion (SE) and water dispersible granules (WG or WDG).

[0080] The inactive excipients used in the various formulations are as follows:

[0081] A. Examples of inactive excipients used in oil dispersion (OD) formulations:

[0082] The wetting agent used in the oil dispersion (OD) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzenesulfonate, alkyldiphenyl sulfonate, sodium isopropyl naphthalene sulfonate, alkylnaphthalene sulfonate or mixtures thereof.

[0083] The wetting, diffusing and penetrating agent for oil dispersant (OD) is selected from silicone surfactant trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethylsiloxane copolymer, heptamethyl trisiloxane, polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, which may or may not be in modified form, in liquid or powder form or a mixture thereof.

[0084] The emulsifier used for the oil dispersant (OD) is selected from castor oil ethoxylate, alcohol ethoxylate, fatty acid ethoxylate, sorbitan ester ethoxylate, sulphosuccinate, calcium salt of dodecylbenzene sulfonate, alkylammonium salt of alkylbenzene sulfonate, alkyl sulfosuccinate, ethylene oxide-propylene oxide block copolymer, ethoxylated alkylamine, ethoxylated alkylphenol, polyoxyethylene sorbitan monolaurate or mixtures thereof.

[0085] The dispersant used for the oil dispersant (OD) is selected from the group consisting of alkyl sulfonates, alkylbenzene sulfonates, alkylaryl sulfonates, alkylphenol alkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylated alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohol alkoxylates, alkoxylated alcohols (e.g., n-butyl alcohol polyethylene glycol ether), block copolymers (e.g., ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium lignin sulfonate, sodium polycarboxylate, EO / PO-based copolymers, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyrylphenyl ether, polyol ... ether), tristyrylphenol-polyglycolether-phosphate, tristyrylphenol with 16 mols of EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallowfattyamine polyethylene oxide, nonylphenol polyglycol ether with 9 to 10 mols of ethylene oxide, or mixtures thereof.

[0086] The stabilizer for the oil dispersant (OD) is selected from hectorite clay, magnesium aluminum silicate, bentonite clay, silica, attapulgite clay or mixtures thereof.

[0087] The defoamer for oil dispersant (OD) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoaming emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, or mixtures thereof.

[0088] The antifreeze agent used for the oil dispersant (OD) is selected from ethylene glycol, propylene glycol, glycerol or urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerol, urea, magnesium sulfate heptahydrate, sodium chloride; the preservative is 1,2-benzisothiazolin-3(2H)-one (sodium salt) (1,2-benzisothiazolin-3(2H)-one, sodium salt), sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazoline-3-one, 2-methyl-4-isothiazoline-3-one or a mixture thereof.

[0089] As the solvent of the present preparation, the solvent for the oil dispersant (OD) is selected from but not limited to vegetable oil (plant, seed or tree) or its alkylate or ethoxylate or ester. The alkylated vegetable oil can be methylated vegetable oil or ethylated vegetable oil. Vegetable oil includes olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil. Alkyl esters of vegetable oil; methyl, ethyl, propyl or butyl esters of vegetable oil. Some examples are methylated seed oils, polyoxyalkylene-modified polydimethylsiloxane alkylphenol ethoxylates, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl ester, rapeseed oil butyl ester, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cottonseed oil methyl ester, cottonseed oil ethyl ester, cottonseed oil butyl ester, cottonseed oil propyl ester, tall oil fatty acid esters - tallow methyl ester, tallow ethyl ester, tallow propyl ester, biodiesel, mineral oil (aromatic solvents, isoparaffins, alkaline solvents), fatty acid amides (e.g. C1-C3 amines, alkylamines or having C6-C 18 The oil-based carriers / diluents may be used alone or in admixture of two or more thereof as desired.

[0090] The cosolvent for the oil dispersant (OD) is selected from cyclohexanone, acetophenone, NMP, dimethyl sulfoxide, benzyl alcohol, butanol, N-octanol, N-propanol, 2-ethylhexanol, tetrahydrofurfuryl alcohol, isophorone, fatty acid dimethylformamide, 2-hexylethyl lactate, propylene carbonate or a mixture thereof.

[0091] More specifically, the present invention also relates to a method of making an oil dispersant formulation, the following steps being described.

[0092] It should be understood that the steps described below are applicable to all manufacturing methods.

[0093] Step 1: Ensure the cleanliness of all equipment in the plant and obtain approval from the quality control (QC) department before starting the method.

[0094] Step 2: Ensure electrical connections and standardize the weighing balance.

[0095] Manufacturing method for oil dispersant (OD) formulation:

[0096] Part A - Preparation of Liquid Premix

[0097] Step 1: Place vegetable oil or other solvent or both into a container with an anchor stirrer.

[0098] Step 2: Add emulsifier and dispersant under stirring until all ingredients are completely dissolved.

[0099] Part B - Slurry Preparation

[0100] Step 1: Charge the liquid premix into a second container equipped with a cooling and heating device of a high shear mixer.

[0101] Step 2: Add the active ingredient and homogenize thoroughly. The mixture is pre-milled and the particle size distribution is achieved according to the technical specifications by final milling with a bead mill.

[0102] Part C - Preparation of Thickener Gel

[0103] Step 1: Charge the vegetable / plant / seed oil or solvent into a container equipped with a high shear mixer.

[0104] Step 2: Gradually add thickener, maintaining high shear mixing and stirring continuously throughout the process, until thoroughly combined.

[0105] Step 3: Add the thickener activator while stirring. Also, allow the gel to swell while keeping mixing.

[0106] Part D - Preparation of Final Formulation

[0107] Step 1: Add the thickener gel and disperse the mixture by applying a high shear stirrer.

[0108] Step 2: Add a wetting and spreading agent or adjuvant (silicone or non-silicone based) as described above to the formulation and disperse it by applying a high shear mixer.

[0109] Step 3: Check the final formulation against technical specifications.

[0110] Step 4: After approval, the material is packed in the required packing size.

[0111] B. Examples of inactive excipients used in suspension concentrate (SC) formulations:

[0112] The wetting agent for suspension concentrate (SC) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, polyalkoxylated butyl ethers, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates, silicone surfactants (as wetting diffusion penetrants): trisiloxane ethoxylates, polydimethylsiloxanes, polyoxyethylene methylpolysiloxanes, polyoxyalkylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, heptamethyltrisiloxane, modified forms: polyoxyalkylene-modified heptamethyltrisiloxane, polyether-modified polysiloxanes, polyoxyalkylene-modified trisiloxanes, polyoxyalkylene-modified polydimethylsiloxanes, trisiloxane ethoxylates, polyoxyethylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, polyether-modified polysiloxanes, which may or may not be in modified form and may be in liquid or powder form or a mixture thereof.

[0113] The dispersant used in the suspension concentrate (SC) is selected from naphthalene sulfonicacid, sodium salt condensates with formaldehyde, alkylated naphthalene sulfonates (sodium salt), sodium salt of naphthalene sulfonate condensate, sodium lignin sulfonate, sodium polycarboxylate, EO / PO based copolymers, phenol sulfonates, sodium methyl oleyl taurate, styrene acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide, or mixtures thereof.

[0114] The suspending agent used in the suspension concentrate (SC) is selected from magnesium aluminum silicate, bentonite clay, silica, attapulgite clay or mixtures thereof.

[0115] The defoamer for suspension concentrate (SC) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10Fatty alcohol compounds, silicone antifoaming emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, or mixtures thereof.

[0116] The antifreeze agent used for suspension concentrate (SC) is selected from ethylene glycol, propylene glycol, glycerol or urea, glycols (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerol, urea, magnesium sulfate heptahydrate, sodium chloride or mixtures thereof.

[0117] The preservative used in the suspension concentrate (SC) is selected from 1,2-benzisothiazolin-3(2H)-one (sodium salt), sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one or a mixture thereof.

[0118] The thickener used for the suspension concentrate (SC) is selected from xanthan gum, PVK, carboxymethyl cellulose, polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, gum arabic or a mixture thereof.

[0119] The humectant used in the suspension concentrate (SC) is selected from urea, humic acid, glycerol, lactose or a mixture thereof.

[0120] More specifically, the present invention also relates to a method of making a suspension concentrate formulation, the following steps being described.

[0121] Manufacturing method for suspension concentrate (SC) formulations:

[0122] Step 1: Gel Preparation: Charge the required amount of water in a container equipped with a high shear mixer while starting to stir. Also, add the required amount of preservatives and mix to form a homogeneous mixture. Add the required amount of thickener and mix vigorously to achieve wetting.

[0123] Step 2: Charge the required amount of water into a container equipped with a bulk agitator and a high shear homogenizer. Start stirring. Also, add the required amount of antifreeze and mix to achieve uniformity. Add the defoamer and ensure it is well dispersed. Also, mix the wetting dispersant to achieve uniformity while ensuring that the dispersant is fully dispersed.

[0124] Step 3: Add the active ingredient while stirring the container contents to achieve dissolution of all ingredients. Grind the premix by sand mill or bead mill to achieve the specified particle size.

[0125] Step 4: Add the rest of the antifoaming agent to this pre-milled formulation and mix uniformly.Add the required amount of aqueous pre-gel and suspending agent and continue stirring to achieve the target viscosity and uniform formulation.

[0126] Step 5: Submit final product for quality control approval.

[0127] Step 6: After approval, the material is packaged in the required packaging size.

[0128] C. Examples of inactive excipients used in suspoemulsion (SE) formulations:

[0129] The solvent for suspoemulsion (SE) is selected from water, water-soluble alcohol and dihydroxy alcohol ether. Water-soluble alcohol or lower alcohol (1 to 4 carbon atoms) include methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol. Macromolecular alcohol includes polyethylene glycol, sorbitol, glucitol. Dihydroxy alcohol ether includes dihydroxy alcohol alkyl ether or dihydroxy alcohol aryl ether. The example of dihydroxy alcohol alkyl ether includes ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether and dipropylene glycol ethyl ether. The example of dihydroxy alcohol aryl ether includes ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether etc. Any of the solvents can be used alone or in combination.

[0130] Hydrocarbons include n-pentane, hexane, cyclohexane, methylcyclohexane, heptane, isooctane, benzene, toluene, xylene, isophorone, ester solvents such as methyl oleate, C6-C 16 Dimethylamide and morpholineamide derivatives of fatty acids, monoolefin carbonates such as ethylene carbonate, propylene carbonate and butylene carbonate, dimethyl sulfoxide (DMSO), 2-ethylhexanol, n-butanol, n-alkylpyrrolidone, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic and / or aliphatic hydrocarbons, one or more dimethylamides (e.g. C8-dimethylamide, C 10 -dimethylamide, C 12 1,3-dimethyl-2-imidazolidonone, lactic acid esters, dimethyl carbonate and diethyl carbonate, alcohols (including methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol and tert-butanol), methyl L-lactate, 2-ethylhexyl L-lactate, ethyl L-lactate, n-butyl L-lactate, octylphenol ethoxylate or mixtures thereof.

[0131] The emulsifier used for the suspoemulsion (SE) is selected from dodecylbenzene sulfonate (such as calcium salt or amine salt), other C 11 -C 16 alkylbenzene sulfonates, alkyl ether sulfates, alkylphenol ether phosphates and ester phosphates, nonionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils (e.g. ethoxylated castor oil), fatty acid esters such as sorbitol and ethoxylated derivatives thereof, ethoxylated amines, condensates of glycerol, catanionic emulsifiers such as cationic amines (optionally in combination with alkyl sulfonates or ether sulfonates or ether phosphates), alkoxylated alcohols, alkoxylated alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated tristyrylphenol (tristyrylphenol with 16 mol EO), tristyrylphenol-polyethylene glycol ether-phosphates, fatty acid esters of sorbitol and ethoxylated derivatives thereof, ethoxylated amines, condensates of glycerol, C 11 -C 16 Sulfonated alkylbenzenes and salts thereof within the scope of the present invention, alkyl ether sulfates, alkyl ether phosphates, alkylphenol ether phosphates or combinations thereof, salts of phosphate esters of ethoxylated tristyrylphenol, salts of sulfated ethers of ethoxylated tristyrylphenol, or catanionic systems in which cationic amines are present in combination with alkyl sulfonates, alkyl ether sulfonates, ether sulfates or ether phosphates (e.g. alkyl ether phosphates), nonylphenol polyethoxyethanol, castor oil polyglycol ether, polyadducts of ethylene oxide and polypropylene, tributylphenoxypolyethoxyethanol, octylphenoxypolyethoxyethanol or mixtures thereof.

[0132] The stabilizer used in the suspoemulsion (SE) is selected from butylated hydroxytoluene (BHT) and epoxidized soybean oil (ESBO), epichlorohydrin or a mixture thereof.

[0133] The antifreeze agent used in the suspoemulsion (SE) is selected from ethylene glycol, propylene glycol, glycerol or urea, glycols (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerol, urea, magnesium sulfate heptahydrate, sodium chloride or a mixture thereof.

[0134] The defoamer for suspoemulsion (SE) is selected from silicone oil, silicone compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoaming emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, or mixtures thereof.

[0135] The suspending agent used in the suspoemulsion (SE) is selected from magnesium aluminum silicate, bentonite clay, silica, silicon dioxide, attapulgite clay or mixtures thereof.

[0136] The wetting agent used in the suspoemulsion (SE) is selected from ethylene oxide / propylene oxide block copolymers, polyarylphenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyldiphenyl sulfonates, sodium isopropylnaphthalene sulfonate, alkylnaphthalene sulfonates, octylphenol ethoxylates, alkylphenol ethoxylates or mixtures thereof.

[0137] The wetting, diffusing and penetrant agent for the suspoemulsion (SE) is selected from the group consisting of silicone surfactants trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methylpolysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyoxyalkylene-modified heptamethyltrisiloxane, heptamethyltrisiloxane ethoxylate, polyether-modified polysiloxane, 10 moles of ethylene oxide adduct of octylphenol, which may or may not be in modified form, and may be in liquid or powder form or a mixture thereof.

[0138] The preservative used in the suspoemulsion (SE) is selected from propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxybenzoic acid sodium salt, methyl p-hydroxybenzoate and biocides such as sodium benzoate, 1,2-benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isoxazolin-3-one, potassium sorbate, p-hydroxybenzoic acid esters or mixtures thereof.

[0139] Thickeners for suspoemulsions (SE) are selected from thickeners, gelling agents and anti-settling agents, which are generally divided into two categories, i.e., water-insoluble particles and water-soluble polymers. Suspension concentrate formulations can be prepared using clay and silicon dioxide. Examples of these types of materials include, but are not limited to, montmorillonite (e.g., bentonite), magnesium aluminum silicate and attapulgite. Water-soluble polysaccharides have been used for many years as thickening-gelling agents. The most commonly used polysaccharide types are natural extracts of seeds and 15 species of seaweed, synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum, locust bean gum, carrageenan, xanthan gum, alginates, methylcellulose, sodium carboxymethylcellulose (SCMC), hydroxyethylcellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starch, polyacrylates, polyethylene 20 alcohol and polyethylene oxide or mixtures thereof.

[0140] Dispersants for suspoemulsions (SE) are selected from, for example, conventionally available polyesters, polyamides, polycarbonates, polyureas and polyurethanes, acrylic polymers, acrylic graft copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinyl alcohol, vinyl acetate and vinyl pyrrolidone polymers and copolymers, polyethers, epoxy resins, phenolic resins and melamine resins, polyolefins, and copolymers and mixtures thereof are defined. Examples of preferred polymers are acrylate polymers (e.g., poly(methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate)), acrylate copolymers and styrene-acrylic copolymers as defined below, poly(styrene-co-maleic anhydride), cellulosic polymers (e.g., ethyl cellulose, cellulose acetate, cellulose acetate butyrate), acetylated monoglycerides, acetylated diglycerides and acetylated triglycerides, poly(vinyl pyrrolidone), vinyl acetate polymers and copolymers, poly(ethylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more thereof. Biodegradable polymers may also be used in the present invention. As used herein, a polymer is biodegradable, even if it is insoluble in water, but will degrade after being placed in the application environment for several weeks. Examples of biodegradable polymers that can be used in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly(n-amyl methacrylate), wood rosin, polyanhydrides, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters, polyhydroxybutyrates, or mixtures thereof. Examples of dispersants are alkylated naphthalene sulfonates (sodium salts), sodium salts of naphthalenesulfonic acid condensates, sodium salts of alkylnaphthalenesulfonic acids, sodium lignin sulfonates, sodium polycarboxylates, EO / PO block copolymers, phenol sulfonates, sodium methyl oleoyl taurate, styrene acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide, or mixtures thereof.

[0141] The buffer for the suspoemulsion (SE) is selected from calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphate, carbonated calcium phosphate, amine monomers, lactate dehydrogenase, magnesium hydroxide or mixtures thereof.

[0142] The humectant used in the suspoemulsion (SE) is selected from urea, humic acid, glycerol, lactose or a mixture thereof.

[0143] The present invention also relates to a method for preparing a suspoemulsion formulation, describing the following steps:

[0144] Manufacturing method of suspoemulsion (SE) preparation:

[0145] Step 1: Gel Preparation: Charge the required amount of water in a container equipped with a high shear mixer while starting to stir. Add the required amount of preservative and mix to achieve homogeneity. Also, add the required amount of thickener and mix vigorously to achieve complete wetting.

[0146] Step 2: Oil phase: Charge the solvent into a container, then slowly add the active material, heat it to 50°C if necessary so that the active ingredient can be dissolved in the solvent, followed by the emulsifier.

[0147] Step 3: When the required amount of water is charged into a container equipped with a bulk agitator and a high shear homogenizer, start stirring. Add the required amount of antifreeze and mix to achieve a uniform mixture. Add the defoamer and ensure it is well dispersed. Add the wetting agent and dispersant and mix to achieve a uniform mixture, ensuring that the dispersant is fully dispersed.

[0148] Step 4: Add active ingredients to the container and stir until all ingredients are dissolved. Grind the premix through a colloid mill and then a dyno mill to achieve the specified particle size.

[0149] Step 5: Add the remaining defoamer to the abrasive base in a container equipped with a large volume stirrer and mix to achieve homogeneity.

[0150] Step 6: Add the oil phase to the water phase and stir by using a homogenizer for 30 minutes.

[0151] Step 7: Add required amount of aqueous pre-gel and suspending agent. Achieve homogeneous mixture and target viscosity by continuous stirring.

[0152] Step 8: Submit final product for quality control approval.

[0153] Step 9: After approval, the material is packed in the required packing size.

[0154] D. Examples of inactive excipients used in WG (wettable granules) formulations:

[0155] The dispersant used for wettable granules (WG) is selected from sodium polycarboxylate (sodium polyacrylate), naphthalenesulfonic acid, sodium salt condensate with formaldehyde, polyalkoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphthalene-formaldehyde condensate sodium salt, naphthalene condensate, lignin sulfonate, calcium lignin sulfonate, sodium lignin sulfonate, alkylnaphthalene sulfonate (sodium salt). The preferred dispersant is alkylnaphthalene sulfonate. It provides excellent wettability, dispersibility, hydrophilicity and low to medium foaming properties. It provides acid-base stability, hard water resistance and high temperature stability or a mixture thereof.

[0156] The wetting agent for wettable granules (WG) is selected from sodium N-methyl-N-oleyl taurate, alkylated naphthalene sulfonates (sodium salt), a mixture of isomers of dibutylnaphthalene sulfonate sodium salt, sodium diisopropylnaphthalene sulfonate, sodium lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonate, phosphate esters, sulphosuccinate, nonionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonate, α-olefin sulfonates and alkylnaphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharides, di or mono alkyl sulfosuccinate derivatives, α-olefin sulfonates, alkylnaphthalene sulfonates, dialkyl sulfosuccinates, butylnaphthalene sulfonates, dibutylnaphthalene sulfonates, isopropylnaphthalene sulfonates and diisopropylnaphthalene sulfonates, C 12 Alkylbenzene sulfonate or C 10 -C 16 Alkylbenzene sulfonate, silicone surfactant trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methylpolysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyoxyalkylene modified heptamethyltrisiloxane, polyether modified polysiloxane, which may or may not be in modified form, and may be in liquid or powder form or a mixture thereof.

[0157] The defoaming agent used in wettable granules (WG) is selected from polydimethylsiloxane or a mixture thereof.

[0158] The carrier for wettable granules (WG) is selected from china clay, silica, anhydrous lactose, ammonium sulfate, anhydrous sodium sulfate, corn starch, urea, EDTA, urea-formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, Fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulfate, sodium chloride, gypsum, calcium sulfate, pyrophyllite, silicates and silica gel; fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate and urea; natural products of plant origin such as grain meal and flour. flour, bark meal, wood meal, nut shell meal and cellulose meal; and synthetic polymeric materials, such as ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminum oxides and hydroxides, or organic materials, such as bagasse, charcoal, or synthetic organic polymers, or mixtures thereof.

[0159] The humectant used in wettable granules (WG) is selected from humic acid, glycerol, lactose, anhydrous sodium sulfate or a mixture thereof.

[0160] More specifically, the present invention also relates to a process for preparing a water dispersible granule formulation, describing the following steps:

[0161] Production method of WG / WDG (water dispersible granules):

[0162] Step 1: Take the exact weight of active ingredient and add it in a blender, then add required amount of binder and surfactant and mix to achieve complete homogenization.

[0163] Step 2: The homogeneous mixture is milled until desired wet sieving is achieved and then blended to obtain homogeneity.

[0164] Step 3: The above homogenized material is passed through an extruder to be pelletized.

[0165] Step 4: Remove excess water by passing the granules through a fluid bed dryer.

[0166] Step 5: Transfer the pellet to a vibrating transposer.

[0167] Step 6: Collect the final material from the vibrating shifter into a bucket.

[0168] Step 7: Submit final product for quality control approval.

[0169] Step 8: After getting approval from the quality control department, transfer the material into drums of different sizes.

[0170] Example

[0171] The present invention has been described with reference to specific embodiments, which are merely illustrative and are not intended to limit the scope of the invention as defined in this entire specification.

[0172] Biological Examples:

[0173] The synergistic insecticide action of the mixture of the present invention is demonstrated by the following experiments. A synergistic effect exists whenever the action of the combination (premix) or pot mix of the active ingredients is greater than the sum of the actions of each ingredient alone. Thus, a synergistically effective amount or effective amount of a synergistic composition or combination is an amount that exhibits an insecticide activity greater than the sum of the insecticide activities of the individual ingredients.

[0174] In the agricultural field, it is generally understood that the term "synergistic effect" is defined as Colby SR in an article entitled "Calculation of the synergistic and antagonistic responses of herbicide combinations" (published in the journal Weeds, 1967, 15, pp. 20-22), which is incorporated herein by reference in its entirety. The expected effect for a given combination of two or three active ingredients can be calculated as follows:

[0175] Colby's formula for calculating the synergistic effect between two active ingredients,

[0176]

[0177] Where E = expected / calculated control of the mixture or combination of Compound A and Compound B at a defined dose, X = observed control of Compound A, and Y = observed control of Compound B.

[0178] Colby's formula for calculating the synergistic effect between three active ingredients,

[0179]

[0180] Where E = expected / calculated control of a mixture or combination of Compound A, Compound B and Compound C at a defined dose, X = observed control of Compound A, Y = observed control of Compound B, and Z = observed control of Compound C.

[0181]

[0182] If the Colby ratio is >1 it means that a synergistic effect is observed, <1 means that an antagonistic effect is observed and =1 means a simple additive effect.

[0183] A higher ratio means a stronger synergistic effect, and a lower ratio means a weaker synergistic effect.

[0184] The aim of this study was to investigate synergistic effects and benefits. Various formulations of fluoxetine, at least two amide insecticides, at least one or more compounds selected from the group consisting of insecticides, fungicides or plant health additives were analyzed.

[0185] More specifically, the study involved and analyzed fluoxetine, at least one diamide insecticide and one or more pesticides; fluoxetine, at least one diamide insecticide and at least one fungicide; and fluoxetine, at least one diamide insecticide and at least one plant health additive.

[0186] Biological efficacy of fluoxetine + at least one diamide insecticide + at least one insecticide:

[0187] Example 1: Biological efficacy against pepper thrips and fruit borers and its effect on yield

[0188] Crop: Pepper

[0189] Location: Umrat, Gujarat

[0190] Number of processing times: 28

[0191] Plot size: 50sq.m. (square meters)

[0192] Crop stage: 77 days after transplanting

[0193] Method of application: Foliar spraying with a battery-powered backpack sprayer

[0194] Water volume: 470 liters / hectare

[0195] Observation method:

[0196] Thrips (Scirtothrips dorsalis): Live thrips were counted by shaking the shoots on black paper. Observations were recorded for 3 shoots per plant and 10 plants per plot at 7 and 14 DAA (days after application). Thrips control (%) was calculated as observed control and synergistic effects were calculated using the colby formula.

[0197]

[0198] Fruit borer (mixed infestation of Helicoverpa armigera and Spodoptera exigua) larvae control (%): The number of live larvae per plant was counted. Observations were recorded on 10 plants per plot 14 days after application.

[0199]

[0200] The fruit borer larvae control (%) data were used to examine synergistic effects by applying Colby's formula given above.

[0201] Healthy fruit count: The number of healthy fruits per plant was counted. Observations for 10 plants per plot were recorded and the increase (%) in healthy fruits relative to UTC (untreated check) was calculated.

[0202]

[0203] T3: Composition of fluazifop 3.33% + chlorfenapyr 2.4% + tolfenpyrad 12% SC

[0204]

[0205]

[0206] Based on 100% pure active ingredients

[0207]

[0208]

[0209]

[0210] Fluoxathiapiprole 3.33% + Chlorantraniliprole 2.4% + Tolafenamide 12% SC (T3) for 100kg batch Manufacturing method

[0211] Step 1: 2% gum solution: Xanthan gum (2.0 kg) and 1,2-benzisothiazolin-3-one (2.0 kg) were added to 96.0 kg water and homogenized. This was prepared 12 to 18 hours before use.

[0212] Step 2: Charge DM water (55.07 kg) and 1,2-propylene glycol (5 kg) into a designated container and mix thoroughly.

[0213] Step 3: Sodium naphthalenesulfonate formaldehyde condensate (1.25 kg), ethylene oxide-propylene oxide block copolymer (4.75 kg), dioctyl sulfosuccinate (2.0 kg) and magnesium aluminum silicate (0.5 kg) were added to a container with water and the contents were homogenized using a high shear homogenizer for 45 to 60 minutes.

[0214] Step 4: Fluoxetine (3.33 kg), Chlorantraniliprole (2.40 kg) and Tolfenpyrad (12.0 kg) were then slowly added to the premix and homogenized to obtain a homogenous slurry ready for grinding.

[0215] Step 5: Before grinding, half the amount of polydimethylsiloxane (0.15 kg) was added and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0216] Step 6: After the grinding process was completed and before sampling for in-process analysis, the remaining polydimethylsiloxane (0.15 kg) antifoaming agent was added.

[0217] Step 7 - Finally, 10.0 kg of 2% xanthan gum solution and 5.0 kg of methylated seed oil, polyoxyalkylene modified trisiloxane were added to the formulation and homogenized for 30 minutes.

[0218] Step 8: Perform quality control for quality inspection.

[0219] T5: Fluoxetine 5% + Cyantraniliprole 8% + Lambda Cyhalothrin 2% ZC

[0220]

[0221]

[0222]

[0223] For room temperature storage stability up to 12 months

[0224]

[0225]

[0226] Preparation of fluoxetine 5% + cyantraniliprole 8% + lambda cyhalothrin 2% ZC (T5) for 100kg batches Manufacturing method

[0227] Step 1: Preparation of 2% gum solution: 2 kg of xanthan gum and 2 kg of 1,2-benzisothiazolin-3-one were added to 96 kg of water and homogenized, which was prepared 12 to 18 hours before use.

[0228] Step 2: Add CS premix (20% lambda cyhalothrin)-12.0 kg aromatic solvent to another slowly stirred container. Add 20.0 kg lambda cyhalothrin, 2.5 kg 4,4'-diphenylmethane diisocyanate, add 50.70 kg water, 1.2 kg alkylbenzene sulfonic acid calcium salt, 1.6 kg sodium naphthalene sulfonate formaldehyde condensate, 0.5 kg polydimethylsiloxane in another container and mix properly for 30 to 45 minutes. Add lambda cyhalothrin premix to the water phase under high shear to get the desired particle size, then add 1.5 kg diethylenetriamine, heat the formulation under low stirring for 3 to 4 hours, then cool to room temperature, add 10 kg of 2% gum solution.

[0229] Step 3: Charge 55.35 kg of DM water and 5 kg of 1,2-propylene glycol into a designated container and mix thoroughly.

[0230] Step 4: 2.5 kg of acrylic graft copolymer, 3.50 kg of tristyrylphenol polyethoxylate phosphate, 1.50 kg of attapulgite clay, and 0.05 kg of polydimethylsiloxane were added to a container with water, and the contents were homogenized using a high shear homogenizer for 45 to 60 minutes.

[0231] Step 5: 8.0 kg of cyantraniliprole and 5.0 kg of fluazifop were then slowly added to the premix and homogenized to obtain a homogenous slurry ready for grinding.

[0232] Step 6: Before grinding, add half the amount of defoamer and then grind the material in a Dyno mill until the desired particle size is achieved.

[0233] Step 7: After the grinding process is complete and before sampling for in-process analysis, the remaining 0.10 kg of polydimethylsiloxane antifoam is added.

[0234] Step 8: Now mix 10% of the 20λ CS formulation premix into this milled slurry under slow stirring and homogenize for 30 to 45 minutes.

[0235] Step 9: Finally, 9.0 kg of 2% gum solution was added to the formulation and then sent for quality control for quality checking.

[0236] Table 1: Processing details

[0237]

[0238]

[0239] ZC - zeon concentrate, SC - suspension concentrate, EC - emulsifiable concentrate, OD - oil dispersant. T1 to T8 are compositions of the present invention, T9 to T20 are known compositions, T21 to T27 are market products.

[0240] Table 2a: Thrips control in pepper crops

[0241]

[0242]

[0243] Compared with all known compositions (T9 to T20) and market products (T21 to T27), all compositions of the present invention (T1 to T8) showed synergistic control and residual control up to 14 days. The Colby ratio of all compositions of the present invention (T1 to T8) is greater than 1, which means that the synergistic effect is stronger.

[0244] Table 2b: Fruit borer larvae control and pepper fruit yield

[0245]

[0246]

[0247] All compositions of the invention (T1 to T8) provided synergistic control of fruit borer larvae and produced the highest number of marketable fruits per plant (<110% increase relative to UTC).

[0248] Conclusion: Among the various compositions shown in Table 1, treatment numbers T1 to T8 were considered to be the compositions of the present invention showing excellent synergistic effect and effectiveness against pepper thrips and fruit borer larvae on pepper crops. The thrips control observed at 7 DAA (days after application) for T1 to T8 was 100%, and the Colby ratio was found to be greater than 1, which means that the synergistic effect is strong. Moreover, the thrips control observed at 14 DAA exceeded 86%. In particular, when compared with other known products and market products, T7 (98.8%), T6 (98.4%) and T8 (98.0%) showed the highest thrips control at 14 DAA, achieved a Colby ratio greater than 1, and exhibited an effective synergistic effect.

[0249] In addition, T1 to T8 showed 100% effectiveness in controlling fruit borer larvae at 14 DAA, providing more than 41 healthy fruits per plant, of which T7 was shown to provide the most 47.3 healthy fruits per plant, followed by T6 (46.8) and T8 (45.5). In addition to this, T1 to T8 also showed a substantial increase of more than 100% in fruits relative to UTC (untreated control) compared to other known products and market products, especially T7 showed an increase of 141.3% in fruits relative to UTC, followed by T6 (138.8%) and T8 (132.1%).

[0250] Example 2: Red spider mite, shoot and fruit borer control and yield in eggplant Crop: Eggplant

[0251] Location: Asodar, Gujarat

[0252] Number of times processed: 26

[0253] Plot size: 60sq.m.

[0254] Crop age: 80 days after transplanting

[0255] Method of application: Foliar spraying with a battery-powered backpack sprayer

[0256] Water volume: 500 liters / hectare

[0257] Observation method:

[0258] Red spider mite (Tetranychus urticae) control (%): The number of motile stages of mites per unit area was counted using a 10x microscope. Observations were recorded for 5 sites per plant and 10 plants per plot. Red spider mite control (%) was calculated and colby's formula was applied.

[0259]

[0260] Shoot and Fruit Borer (Leucinoides orbonalis) Control (%): Larvae of stalk and fruit borer cause damage to twigs and fruits of brinjal crops. The number of healthy and infested twigs, healthy and infested fruits were counted for each plant. Observations were recorded for 10 randomly selected plants in each plot.

[0261]

[0262] Fruit counts: The number of healthy marketable fruits of 5 plants per plot was counted and the increase in healthy fruits relative to UTC was calculated.

[0263] T2: Fluoxetine 4% + Chlorantraniliprole 5% + Hexathiazolin 4% OD

[0264] Chemical composition Percentage (w / w) Fluoxathiazide (active ingredient) 4.00 Chlorantraniliprole (active ingredient) 5.00 Hexathiazolin (active ingredient) 4.00 Polyoxyethylene sorbitan hexaoleate (oil emulsifier) 10.00 Salts of polyolefin condensates (non-aqueous dispersants) 2.50 Ethoxylated sorbitan esters (co-emulsifiers) 8.50 Bentonite Clay (Rheology Modifier) 1.50 Styrene acrylic polymer (water-based dispersion) 1.50 Methylated seed oil (oil continuous phase) 63.00 total 100.00

[0265] Based on 100% pure active ingredients

[0266]

[0267]

[0268] For room temperature storage stability up to 12 months

[0269]

[0270] For the production of 100kg batch of fluoxathiapiprole 4% + chlorfenapyr 5% + hexathiazolin 4% OD = (T2) method

[0271] Step 1: 15% Bentonite Clay Solution Preparation:

[0272] 15 kg of precipitated silica is added to 85 kg of methylated seed oil and homogenized until it is completely dissolved. It must be kept for 12 to 18 hours before use.

[0273] Step 2: OD premix:

[0274] 53.0 kg of methylated seed oil was charged into a designated container for the preparation of OD.

[0275] At this point, 10.0 kf of polyoxyethylene sorbitol hexaoleate, 1.50 kg of styrene acrylic polymer, 8.50 kg of ethoxylated sorbitan esters, 2.50 kg of salts of polyolefin condensates and 0.15 kg of polydimethylsiloxane were added and the contents were homogenized for 45 to 60 minutes using a high shear homogenizer. 4.0 kg of fluoxazolidinone, 5.0 kg of chlorfenapyr and 4.0 kg of hexathiapiprolin were added to the premix and homogenized for 30 to 45 minutes. The remaining 0.15 kg of silicon defoamer and 10 kg of 15% silicon dioxide solution were added after grinding to avoid foaming and then sent for quality control for quality inspection.

[0276] Composition of fluoxetine 2% + cyantraniliprole 4.5% + diafenthiuron 20% SC in T8

[0277]

[0278] Based on 100% pure active ingredients

[0279]

[0280]

[0281]

[0282] Manufacturing method for 100kg batch of fluoxetine 2% + cyantraniliprole 4.5% + diafenthiuron 20% SC (T8) Law

[0283] Step 1: 2% gum solution: Add xanthan gum (2.0 kg) and sodium benzoate (2.0 kg) to 96.0 kg water and homogenize. Prepare it 12 to 18 hours before use.

[0284] Step 2: Charge DM water (49.80 kg) and 1,2-propylene glycol (5 kg) in a designated container and mix thoroughly.

[0285] Step 3: Sodium polycarboxylate (1.5 kg), tristyrylphenol ethoxylate phosphate (3.5 kg), dioctyl sulfosuccinate (2.0 kg) and magnesium aluminum silicate (0.5 kg) were added to a container with water and the contents were homogenized using a high shear homogenizer for 45 to 60 minutes.

[0286] Step 4: Fluoxetine (2.0 kg), cyantraniliprole (4.50 kg) and diafenthiuron (20.0 kg) were then slowly added to the premix and homogenized to obtain a homogenous slurry ready for milling.

[0287] Step 5: Before grinding, half the amount of dimethicone (0.15 kg) was added and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0288] Step 6: After the grinding process was completed and before sampling for in-process analysis, the remaining polydimethylsiloxane (0.15 kg) antifoaming agent was added.

[0289] Step 7: Finally, 7.5 kg of 2% xanthan gum solution and 5.0 kg of methylated seed oil, polyoxyalkylene-modified trisiloxane were added to the formulation and homogenized for 30 minutes.

[0290] Step 8: Perform quality control for quality inspection.

[0291] Table 3: Processing details

[0292]

[0293] WG - wettable granules, WP - wettable powder. T1 to T8 are compositions of the present invention, T9 to T18 are known compositions, and T19 to T25 are market products.

[0294] Table 4a: Control of Red Spider Mites on Eggplant

[0295]

[0296]

[0297] All compositions of the invention (T1 to T8) provided synergistic control of red spider mites in eggplant crops.

[0298] Table 4b: Efficacy and yield of eggplant crops against twig and fruit borer damage

[0299]

[0300]

[0301] All compositions of the invention (T1 to T8) provided excellent control of twig and fruit borers and also resulted in the production of the highest number of marketable fruits per plant.

[0302] Conclusion: Among the various compositions shown in Table 3, T1 to T8 are the compositions of the present invention that show excellent synergistic effect and effectiveness against red spider mites, branch and fruit borers in eggplant crops. In the T1 to T8 compositions, more than 92% control of red spider mites was observed at 7 DAA (days after application). In addition, T6 was shown to have the maximum control of 99.2% against red spider mites, followed by T7 (98.8%) and T5 (98.4%), and their Colby ratios were greater than 1 compared with known products and market products, demonstrating effective synergistic effects.

[0303] Furthermore, T1 to T8 showed excellent control of twig fruit borers, resulting in 0% twig fruit damage, compared to other known and marketed products. In addition to this, T1 to T8 resulted in more than 78 healthy fruits per five plants, with T4 being shown to result in 83.2 healthy fruits per five plants, followed by T1 (82.5) and T2 (81.7). Furthermore, T1 to T8 showed the largest increase (greater than 80%) in fruits relative to UTC (untreated control). In particular, when compared to other known and marketed products, T4 showed an increase of 95.3% in fruits relative to UTC, followed by T1 (93.7%) and T2 (91.8%).

[0304] Example 3: Pod borer larvae control and yield of pigeon pea (red gram)

[0305] Crop: Pigeon peas

[0306] Location: Sinor, Gujarat

[0307] Processes: 26

[0308] Crop age: 110 days after sowing

[0309] Spray volume: 500 liters / hectare

[0310] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0311] Observation method:

[0312] Bean Pod Borer (Helicoverpa armigera) Larvae Control (%): The number of live larvae was counted per plant. Observations were recorded on 10 plants per plot at day 14 after application.

[0313]

[0314] Pod Count: Count the number of healthy pigeon pea pods per plant. Record observations for 10 plants per plot.

[0315] Composition of fluoxetine 4% + chlorfenapyr 4% + indoxacarb 8% SE T4

[0316] Chemical composition Percentage (w / w) Fluoxathiazide (active ingredient) 4.00 Chlorantraniliprole (active ingredient) 4.00 Indoxacarb (active ingredient) 8.00 Polyarylphenyl anionic ether sulfate ammonium salt (emulsifier-2) 1.50 Aromatic solvent C-9 15.00 Acrylic acid graft copolymer (dispersant I) 3.00 Butyl polyoxyalkylene block copolymer (dispersant II) 4.50 Magnesium aluminum silicate (suspension agent) 0.50 Polydimethylsiloxane (defoaming agent) 0.20 1,2-Benzisothiazolin-3(2H)-one (preservative) 0.15 Polypropylene glycol (antifreeze) 5.00 Xanthan gum (thickener) 0.15 Diluent water 54.00 total 100.00 Based on 100% pure active ingredients

[0317]

[0318] For room temperature storage stability up to 12 months

[0319]

[0320]

[0321] Manufacturing method for 100kg batch of fluoxetine 4% + chlorfenapyr 4% + indoxacarb 8% SE (T4) Law

[0322] Step 1 - 2% gum solution: 2 kg of xanthan gum and 2 kg of 1,2-benzisothiazolin-3-one are added to 96 kg of water and homogenized, which is prepared 12 to 18 hours before use.

[0323] Step 2: EC premix - 15.0 kg of aromatic solvent was added to another slowly stirred container. Now 4.0 kg of fluoxazolidinone, 8.0 kg of indoxacarb and 4.5 kg of butyl polyoxyalkylene block copolymer were added and properly mixed for 30 to 45 minutes.

[0324] Step 3 - Charge 46.5 kg of DM water and 5 kg of 1,2-propylene glycol in a designated container and mix thoroughly.

[0325] Step 4 - Add 0.5 kg of magnesium aluminum silicate, 3.0 kg of acrylic acid graft copolymer, 1.50 kg of polyarylphenyl anionic ether ammonium sulfate salt, and 0.10 kg of polydimethylsiloxane to a container with water and homogenize the contents using a high shear homogenizer for 45 to 60 minutes.

[0326] Step 5 - 4.0 kg of chlorantraniliprole was then slowly added to the premix and homogenized to obtain a homogenous slurry ready for grinding.

[0327] Step 6 - Before grinding, add half the amount of defoamer and then grind the material in a Dyno mill until the desired particle size is achieved.

[0328] Step 7 - After the grinding process is complete and before sampling for in-process analysis, add the remaining 0.10 kg of polydimethylsiloxane antifoam.

[0329] Step 8: Now mix the EC premix into this milled slurry under slow stirring and homogenize for 30 to 45 minutes.

[0330] Step 7- Finally, 7.5 kg of 2% gum solution was added to the formulation and then sent for quality control for quality check.

[0331] Fluoxetine 10% + Cyantraniliprole 20% + Emamectin Benzoate 3.75% WG T5 Composition

[0332]

[0333]

[0334]

[0335]

[0336] For 100kg batches of fluoxetine 10% + cyantraniliprole 20% + emamectin benzoate 3.75% WG(T5) Manufacturing Method

[0337] Step 1 - Charge 29.25 kg china clay, 20.0 kg corn starch, 0.5 kg silicone defoamer, 6 kg sodium naphthalenesulfonate formaldehyde condensate, 5 kg sodium polycarboxylate and 5.0 kg sodium lauryl sulfate into a ribbon or premix blender and blend, homogenizing for 30 minutes.

[0338] Step 2 - Now 10.0 kg of fluoxetine, 1.20 kg of cyantraniliprole and 3.75 kg of emamectin benzoate were charged and homogenized again for 30 minutes, now grinding this pre-blended material by a jet mill / air classifier mill. The finely ground material was blended in a post mixer until it became homogeneous. (about 1.5 hours)

[0339] Step 3 - The finely ground powder was mixed with 10 kg of water with 0.5 kg of silicone antifoam to form an extrudable dough.

[0340] Step 4- The mass is passed through an extruder to obtain pellets of desired size.

[0341] Step 5 - The wet granules were passed through a fluid bed dryer to remove the 10 kg of excess water added and further classified using a vibrating screen.

[0342] Step 6- Send the final product for quality control approval.

[0343] Step 7- After approval, the material is packed in the required packing size.

[0344] Table 5: Processing details

[0345]

[0346]

[0347] WG - wettable granules. T1 to T8 are compositions of the invention, T9 to T16 are known compositions, T17 and T18 are farm tank mixes, T19 to T25 are market products.

[0348] Table 6: Pod borer larvae control and pod yield in pigeon pea

[0349]

[0350]

[0351] All compositions of the invention (T1 to T8) provided synergistic and residual control of pod borer larvae and also resulted in higher number of healthy pods per plant compared to all known compositions, farm tank mixes and market products.

[0352] Conclusion: Among the various compositions shown in Table 5, treatment numbers T1 to T8 were considered as the compositions of the present invention showing excellent synergy and effectiveness in controlling pod borer larvae in pigeon pea. Furthermore, the control of pod borer was shown to be 100% at 14 DAA (days after application) as compared to other known products, farm tank mixes and market products.

[0353] In addition to this, T1 to T8 also resulted in more than 110 healthy pods per plant. In particular, T4 resulted in the highest number of 115.3 healthy pods per plant, followed by T2 (113.2) and T8 (113.1). In addition, T1 to T8 showed an increase of more than 65% in healthy pods relative to UTC (untreated control). In particular, when compared to other known products, farm tank mixes and market products, T4 showed an increase of 72.9% in healthy pods relative to UTC, followed by T2 (69.7%) and T8 (69.6%).

[0354] Example 4: Whitefly and fruit borer larvae control and yield in tomatoes

[0355] Crop: Tomato

[0356] Location: Tolga, Gujarat

[0357] Processes: 26

[0358] Crop age: 96 days after transplanting

[0359] Spray volume: 510 liters / hectare

[0360] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0361] Observation method:

[0362] Whitefly (Bemesia tabaci) control (%): The number of live whiteflies (nymphs and adults) was counted per leaf trifoliate, with observations recorded for 3 leaves per plant and 10 plants per plot.

[0363]

[0364] Fruit borer larvae control (%): Same as given in Example 1.

[0365] Healthy fruit count: Count the number of healthy fruits on each plant. Record observations for 10 plants in each plot.

[0366] Table 7: Processing details

[0367]

[0368] DC - dispersible concentrate. T1 to T8 are compositions of the present invention, T9 to T18 are known compositions, and T19 to T25 are market products.

[0369] Table 8: Whitefly and fruit borer larvae control and yield in tomato

[0370]

[0371]

[0372] All compositions of the invention (T1 to T8) provided synergistic control of whiteflies and fruit borers and also resulted in tomatoes producing a higher number of healthy fruits per plant.

[0373] Conclusion: Among the various compositions shown in Table 7, treatment numbers T1 to T8 were considered to be compositions of the present invention showing excellent synergistic effects and effectiveness against whitefly and fruit borer larvae in tomatoes. Whitefly control of more than 93% was observed for T1 to T8. In particular, T1 gave the highest control of 99.7%, followed by T5 (99.2%) and T8 (98.6%), and the Colby ratio was greater than 1, showing an effective synergistic effect, compared with other known products and market products.

[0374] In addition, T1 to T8 showed more than 93% control of fruit borer larvae. In particular, T3 showed 99.20%, followed by T1 (98.60%) and T4 (98.20%) compared to other known products and market products. In addition to this, T1 to T8 also resulted in more than 32 healthy fruits per plant, and T1 showed 36.4 healthy fruits per plant, followed by T3 (36) and T2 (35.9). In addition, T1 to T8 showed an increase of more than 154% in healthy fruits relative to UTC (untreated control). In particular, when compared to other known products and market products, T1 had an increase of 184.4% in healthy fruits relative to UTC, followed by T3 (181.3%) and T2 (180.5%).

[0375] Example 5: Control of okra fruit borer larvae

[0376] Crop: Okra

[0377] Location: Raipur, Chhattishgarh

[0378] Processes: 26

[0379] Crop age: 64 days after sowing

[0380] Spray volume: 420 liters / hectare

[0381] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0382] Observation method:

[0383] Fruit borer (mixed infestation of Helicoverpa armigera and Spodoptera exigua) larvae control (%): Same as given in Example 1.

[0384] Table 9: Processing details

[0385]

[0386] T1 to T8 are compositions of the present invention, T9 to T18 are known compositions, and T19 to T25 are market products.

[0387] Table 10: Fruit borer larvae control

[0388]

[0389] All compositions of the invention (T1 to T8) provided synergistic larval control on okra crops.

[0390] Conclusion: Among the various compositions shown in Table 9, treatment numbers T1 to T8 were considered to be compositions of the present invention that showed excellent synergistic effects and effectiveness against fruit borer larvae in okra. In addition, when compared with other known products and market products, T1 to T8 showed 100% excellent fruit borer control and achieved a Colby ratio greater than 1, showing an effective synergistic effect.

[0391] Biological efficacy of fluoxetine + at least one diamide insecticide + at least one fungicide:

[0392] Example 6: Control of Helicoverpa larvae and leaf spot diseases on marigold

[0393] Crop: Marigold

[0394] Location: Umrat, Gujarat

[0395] Processes: 16

[0396] Crop age: 60 days after transplanting

[0397] Spray volume: 440 liters / hectare

[0398] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0399] Observation method:

[0400] Larval control (%): As given in Example 1.

[0401] Leaf mottling (Alternaria spp.): Observations on severity of leaf mottling were recorded by observing 100 leaflets (plants) per plot on a 0 to 10 scale, 0 meaning no disease and 10 meaning the plant is completely damaged by the disease, calculating disease severity (PDI percent disease index) and recalculating disease control (%) or reduction relative to the UTC plots.

[0402] Observations were recorded 7 days after administration.

[0403]

[0404] Control of leaf-feeding larvae (%): Count the number of live larvae on each plant and record

[0405] Table 11: Processing details

[0406]

[0407] T1 to T8 are compositions of the present invention, and T9 to T15 are market products.

[0408] Table 12: Larvae and leaf spot control on marigolds

[0409]

[0410] All compositions of the invention (T1 to T8) provided excellent synergistic control of Spodoptera larvae and leaf spot disease and also produced the highest number of commercially viable flowers per plant.

[0411] Conclusion: Among the various compositions shown in Table 11, treatment numbers T1 to T8 were considered to be the compositions of the present invention showing excellent synergistic effect and effectiveness against Spodoptera larvae and leaf spot disease in marigold. Furthermore, T1 to T8 showed more than 93% control of Spodoptera larvae in marigold. In particular, T5 showed 99.2% control of Spodoptera larvae in marigold, followed by T1 (98.6%) and T7 (98.0%), compared to the other compositions mentioned in Table 12.

[0412] In addition to this, T1 to T8 also showed leaf spot disease control of more than 91%. In particular, compared to other T9 to T16 compositions shown in Table 12, T3 and T6 were shown to control leaf spot disease of marigold at 93.4%, T1 showed 92.4%, and the number of marketable flowers per plant of T1 to T8 was between 22 and 26, of which T1 showed a number of marketable flowers per plant of 25.7, followed by T3 and T5 both showing 25.3.

[0413] Example 7: Pod borer and leaf spot disease of mung bean

[0414] Crop: Mung Bean

[0415] Location: Karjan, Gujarat

[0416] Processes: 16

[0417] Crop age: 60 days after transplanting

[0418] Spray volume: 400 liters / hectare

[0419] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0420] Observation method:

[0421] Spodoptera exigua larvae control (%): As given in Example 1.

[0422] Leaf spot (Cercospora spp.) control: As given in Example 6.

[0423] T4 composition of fluopicolide 11% + flubendiamide 10% + fluopicolide 30% WG

[0424] Chemical composition Percentage (w / w) Fluoxathiazide (active ingredient) 11.00 Flubendiamide (active ingredient) 10.00 Fluopyrabamide (active ingredient) 30.00 Modified sodium lignin sulfonate (dispersant I) 7.00 Modified polyacrylate copolymer (dispersant II) 3.00 Sodium Isopropylnaphthalenesulfonate (wetting agent) 5.00 Polydimethylsiloxane (defoaming agent) 1.00 Corn starch 15.00 porcelain clay 18.00 total 100.00 Based on 100% pure active ingredients

[0425]

[0426]

[0427]

[0428] Preparation of 100kg batch of fluoxathiapiprolin 11% + flubendiamide 10% + fluopyrab 30% WG (T4) Manufacturing method

[0429] Step 1 - Charge 18.0 kg china clay, 15.0 kg corn starch, 0.5 kg silicone defoamer, 5 kg sodium isopropylnaphthalene sulfonate, 3 kg modified polyacrylate copolymer and 7.0 kg modified sodium lignin sulfonate into a ribbon or premix blender and blend, homogenizing for 30 minutes.

[0430] Step 2 - Now 11.0 kg of fluopicolide, 10 kg of flubendiamide and 30.0 kg of fluopicolide were charged and homogenized again for 30 minutes, now grinding this pre-blended material by jet mill / air classifier mill. The finely ground material was blended in the post mixer until it became homogeneous. (about 1.5 hours)

[0431] Step 3 - The finely ground powder was mixed with 10 kg of water with 0.5 kg of silicone antifoam to form an extrudable dough.

[0432] Step 4- The mass is passed through an extruder to obtain pellets of desired size.

[0433] Step 5 - The wet granules were passed through a fluid bed dryer to remove the 10 kg of excess water added and further classified using a vibrating screen.

[0434] Step 6- Send the final product for quality control approval.

[0435] Step 7- After approval, the material is packed in the required packing size.

[0436] Table 13: Processing details

[0437]

[0438]

[0439] T1 to T8 are compositions of the present invention, and T9 to T15 are market products.

[0440] Table 14: Control of Spodoptera larvae and leaf spot diseases in mung bean

[0441]

[0442] All compositions of the invention (T1 to T8) provided excellent synergistic control of larval and leaf spot diseases of mung bean.

[0443] Conclusion: Among the various compositions shown in Table 13, treatment numbers T1 to T8 were considered to be the compositions of the present invention showing excellent synergistic effect and effectiveness against Spodoptera larvae and leaf spot disease in mung bean. The T1 to T8 compositions showed more than 94% control over Spodoptera larvae. In particular, T5 showed 99.2% control over beet armyworm larvae, followed by T1 (98.8%) and T6 (98.2%). Moreover, the Colby ratio was found to be greater than 1, demonstrating the effective synergistic effect of the compositions. Apart from this, more than 89% control of leaf spot disease was observed for the T1 to T8 compositions. In particular, T5 showed 91.6% followed by T1 (91.2%) and T7 (90.8%) compared to the other compositions shown in Table 14.

[0444] Biological effects of fluoxetine + at least one diamide insecticide + at least one plant health additive:

[0445] Example 8: Control of Spodoptera larvae on marigolds

[0446] Crop: Marigold

[0447] Location: Umrat, Gujarat

[0448] Processes: 26

[0449] Crop age: 50 days after transplanting

[0450] Spray volume: 400 liters / hectare

[0451] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0452] Observation method:

[0453] Larvae (Helicoverpa armigera) control (%): As given in Example 1.

[0454] Flower Count: Count the number of marketable flowers per plant. Record observations for 5 plants per plot.

[0455] Composition T2 of fluoxetine 10% + chlorantraniliprole 6.67% + Ascophyllum nodosum extract 10% SC

[0456]

[0457]

[0458]

[0459]

[0460] The composition of fluoxetine 10% + chlorantraniliprole 6.67% + Ascophyllum nodosum extract 10% SC met all internal specifications for both laboratory (at 54±2°C and 0±2°C for 14 days) and room temperature (for 12 months) storage stability studies.

[0461] Fluoxetine 10% + Chlorantraniliprole 6.67% + Ascophyllum nodosum extract 10% SC for 100kg batch T2 Manufacturing Method

[0462] Step 1 - 2% gum solution: Add xanthan gum (2.0 kg) and sodium benzoate (2.0 kg) to 96.0 kg water and homogenize. Make it 12 to 18 hours before use.

[0463] Step 2 - Charge DM water (48.13 kg) and 1,2-propylene glycol (5 kg) into a designated container and mix thoroughly.

[0464] Step 3 - Sodium naphthalenesulfonate formaldehyde condensate (1.0 kg), ethylene oxide-propylene oxide block copolymer (4.5 kg) and magnesium aluminum silicate (0.5 kg) were added to a container with water and the contents were homogenized using a high shear homogenizer for 45 to 60 minutes.

[0465] Step 4 - Fluoxetine (10.0 kg), chlorantraniliprole (6.67 kg) and Ascophyllum nodosum extract (10.0 kg) were then slowly added to the premix and homogenized to obtain a homogenous slurry ready for grinding.

[0466] Step 5 - Before grinding, half the amount of polydimethylsiloxane (0.15 kg) was added and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0467] Step 6 - After the grinding process was completed and before sampling for in-process analysis, the remainder of the polydimethylsiloxane (0.15 kg) antifoam agent was added.

[0468] Step 7 - Finally, 7.5 kg of 2% xanthan gum solution and 5.0 kg of methylated seed oil, polyoxyalkylene modified trisiloxane (super wetting diffusing penetrant) were added to the formulation and homogenized for 30 minutes.

[0469] Step 8-The final formulation is now sent for quality control for quality check.

[0470] Composition of fluoxetine 10% + chlorfenapyr 6.67% + amino acid (glycine) 3% SC T6

[0471]

[0472]

[0473]

[0474]

[0475] Fluoxathiapiprole 10% + Chlorantraniliprole 6.67% + Amino Acid (Glycine) 3% SC for 100kg batch (T6) Manufacturing method

[0476] Step 1-2% gum solution: Add xanthan gum (2.0 kg) and 1,2-benzisothiazolin-3-one (2.0 kg) to 96.0 kg water and homogenize. Make it 12 to 18 hours before use.

[0477] Step 2 - Charge DM water (56.18 kg) and 1,2-propylene glycol (5 kg) into a designated container and mix thoroughly.

[0478] Step 3 - Sodium polycarboxylate salt (1.0 kg), acrylic acid graft copolymer (4.5 kg) and bentonite clay (0.5 kg) were added to a container with water and the contents were homogenized using a high shear homogenizer for 45 to 60 minutes.

[0479] Step 4 - Fluoxetine (10.0 kg), chlorfenapyr (6.67 kg) and amino acid (3.0 kg) were then slowly added to the premix and homogenized to obtain a homogenous slurry ready for grinding.

[0480] Step 5 - Before grinding, half the amount of polydimethylsiloxane (0.15 kg) was added and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0481] Step 6 - After the grinding process was completed and before sampling for in-process analysis, the remainder of the polydimethylsiloxane (0.15 kg) antifoam agent was added.

[0482] Step 7 - Finally, 7.5 kg of 2% xanthan gum solution and 5.0 kg of polyoxyalkylene-modified heptamethyltrisiloxane (superwetting diffusing penetrant) were added to the formulation and homogenized for 30 minutes.

[0483] Step 8-The final formulation is now sent for quality control for quality check.

[0484] Table 15: Processing details

[0485]

[0486] T1 to T11 are compositions of the present invention. T12 to T25 are market products.

[0487] Table 16: Larval control and flower production of marigolds

[0488]

[0489]

[0490] All compositions of the invention (T1 to T11) provided synergistic control of Spodoptera larvae feeding on flowers and leaves and also resulted in the production of higher numbers of marketable flowers.

[0491] Conclusion: Among the various compositions shown in Table 16, treatment numbers T1 to T11 are considered to be compositions of the present invention that show excellent synergistic effects and effectiveness against cotton bollworm larvae on marigold. T1 to T11 showed larval control of more than 93%. In particular, T2, T6 and T9 showed larval control of 97.2% on marigold. In addition, T1 to T11 showed a number of marketable flowers of more than 81 per five plants. In particular, T2 provided a number of marketable flowers of 87.8 per five plants, followed by T7 with 86.4 and T11 with 86.2. In addition to this, T1 to T11 also showed an increase of more than 66% in marketable flowers relative to UTC (untreated control). In particular, when compared to other market products, T2 showed an increase of 79.9% in marketable flowers relative to UTC, followed by T7 (77.0%) and T11 (76.6%).

[0492] Example 9: Thrips Control on Roses

[0493] Crop: Roses

[0494] Location: Umrat, Gujarat

[0495] Processes: 16

[0496] Crop age: 108 days after transplanting

[0497] Spray volume: 460 liters / hectare

[0498] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0499] Observation method:

[0500] Thrips (Thrips tabaci) control (%): As given in Example 1.

[0501] Flower Count: Count the number of marketable flowers per plant. Record observations for 5 plants per plot.

[0502]

[0503]

[0504] For room temperature storage stability up to 12 months

[0505]

[0506] The composition of fluoxetine 8.33% + cyantraniliprole 16.67% + gibberellin 0.4% SC met all criteria for both laboratory (at 54±2°C and 0±2°C for 14 days) and room temperature (for 12 months) storage stability studies.

[0507] Fluoxetine 8.33% + Cyantraniliprole 16.67% + Gibberellic Acid 0.4% SC T5 for 100kg batch Manufacturing method

[0508] Step 1-2% gum solution: Add xanthan gum (2.0 kg) and 1,2-benzisothiazolin-3-one (2.0 kg) to 96.0 kg water and homogenize. Make it 12 to 18 hours before use.

[0509] Step 2 - Charge DM water (47.90 kg) and 1,2-propylene glycol (5 kg) into a designated container and mix thoroughly.

[0510] Step 3 - Sodium polycarboxylate (1.5 kg), tristyrylphenol ethoxylate phosphate (4.5 kg) and magnesium aluminum silicate (0.5 kg) were added to a container with water and the contents were homogenized using a high shear homogenizer for 45 to 60 minutes.

[0511] Step 4 - Fluoxetine (8.33 kg), cyantraniliprole (16.67 kg) and gibberellin (0.40 kg) were then slowly added to the premix and homogenized to obtain a homogenous slurry ready for grinding.

[0512] Step 5 - Before grinding, half the amount of polydimethylsiloxane (0.15 kg) was added and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0513] Step 6 - After the grinding process was completed and before sampling for in-process analysis, the remainder of the polydimethylsiloxane (0.15 kg) antifoam agent was added.

[0514] Step 7 - Finally, 10.0 kg of 2% xanthan gum solution and 5.0 kg of polyoxyalkylene-modified heptamethyltrisiloxane were added to the formulation and homogenized for 30 minutes.

[0515] Step 8-The final formulation is now sent for quality control for quality check.

[0516] Table 17: Processing details

[0517]

[0518] T1 to T6 are compositions of the present invention, T7 to T14 are market products, and T15 is a known composition.

[0519] Table 18: Thrips control and rose yield

[0520]

[0521] All compositions of the invention (T1 to T6) provided synergistic and residual (over 14 days) control of thrips infesting roses and also resulted in the production of higher numbers of marketable flowers.

[0522] Conclusion: Among the various compositions shown in Table 17, treatment numbers T1 to T6 were considered to be compositions of the present invention showing excellent synergistic effect and effectiveness against thrips on rose plants. In addition, when compared with the other products mentioned in Table 17, T1 to T6 showed 100% control of thrips at 3 DAA (days after application), and showed more than 97% control of thrips at 7 DAA, more than 91% control at 14 DAA, and achieved a Colby Ratio greater than 1, showing an effective synergistic effect.

[0523] In addition, T1 to T6 also showed a number of commercially available flowers per five plants of 71 to 73. In particular, T6 showed the highest number of commercially available flowers per five plants of 73.8, followed by T4 (73.4) and T3 (72.7). In addition, T1 to T6 also showed an increase of more than 74% in commercially available flowers relative to UTC (untreated control). In particular, compared with other T7 to T16 compositions shown in Table 18, T6 showed an increase of 78.7% in commercially available flowers relative to UTC, followed by T4 (77.7%) and T3 (76.0%).

[0524] Example 10: Control of rice stem borers and leaf rollers

[0525] Crop: Rice

[0526] Location: Rajim, Chhattishgarh

[0527] Processing: 24

[0528] Spray volume: 500 liters / hectare

[0529] Method of application: Foliar spraying using a battery-operated backpack sprayer equipped with a hollow cone nozzle.

[0530] Observation method:

[0531] Control of leaf rollers and stem borers:

[0532] For 10 hills per plot, infestation of stem borers and leaf rollers was observed at the occurrence of dead heart (DH), white ear (WE) and leaf roller damaged leaves (LFD) during the vegetative and reproductive stages. Observations of dead heart percentage and leaf damage percentage (damaged leaves) were recorded at 15 DAA (days after application) during the vegetative stage, and white ear was recorded before harvesting the crop. A leaf was considered damaged by leaf rollers if at least 1 / 3 of the area of ​​the leaf showed symptoms.

[0533] The percentages of DH, WE and LFD in each individual plot were calculated by using the formula described below:

[0534]

[0535] Productive tiller count: Count the number of productive tillers per cluster. At harvest, record observations for 10 clusters per plot.

[0536]

[0537]

[0538]

[0539]

[0540] The composition of fluoxetine 4.4% + cyantraniliprole 7.2% + zinc oxide 2% SC met all criteria for both laboratory (at 54±2°C and 0±2°C for 14 days) and room temperature (for 12 months) storage stability studies.

[0541] Manufacturing method of fluoxetine 4.4% + cyantraniliprole 7.2% + zinc oxide 2% SCT2 for 100kg batch Law

[0542] Step 1-2% gum solution: Add xanthan gum (2.0 kg) and 1,2-benzisothiazolin-3-one (2.0 kg) to 96.0 kg water and homogenize. Make it 12 to 18 hours before use.

[0543] Step 2 DM water (64.30 kg) and 1,2-propylene glycol (5 kg) were added to the designated container and mixed thoroughly.

[0544] Step 3 - Sodium polycarboxylate (1.5 kg), ethylene oxide-propylene oxide block copolymer (4.5 kg), dioctyl sulfosuccinate (2.0 kg) and magnesium aluminum silicate (1.0 kg) were added to a container with water and the contents were homogenized using a high shear homogenizer for 45 to 60 minutes.

[0545] Step 4 - Fluoxetine (4.40 kg), cyantraniliprole (7.20 kg) and zinc oxide (2.0 kg) were then slowly added to the premix and homogenized to obtain a homogenous slurry ready for milling.

[0546] Step 5 - Before grinding, half the amount of polydimethylsiloxane (0.15 kg) was added and the material was then ground in a Dyno mill until the desired particle size was achieved.

[0547] Step 6 - After the grinding process was completed and before sampling for in-process analysis, the remainder of the polydimethylsiloxane (0.15 kg) antifoam agent was added.

[0548] Step 7-Finally, 7.5 kg of 2% xanthan gum solution was added to the formulation and homogenized for 30 minutes.

[0549] Step 8-The final formulation is now sent for quality control for quality check.

[0550] Table 19: Processing details

[0551]

[0552]

[0553] T1 to T5 are compositions of the invention, T6 to T10 are known compositions, T11 to T16 are farm tank mixes and T17 to T23 are commercially available products.

[0554] Table 20: Control of stem borers, leaf rollers and productive tillers in rice crops

[0555]

[0556]

[0557] All the compositions of the invention (T1 to T5) provided comprehensive protection against stem borer (in terms of dead heart and white ear) and leaf roller and also resulted in higher number of productive tillers per tuft which directly contributes to grain yield.

[0558] Conclusion: Among the various compositions shown in Table 18, treatment numbers T1 to T5 were considered to be the compositions of the present invention showing excellent synergistic effect and effectiveness against stem borers (dead heart and white ear) and leaf rollers in rice plants. Moreover, T1 to T5 showed 0% incidence of stem borers (dead heart and white ear) and 100% control of leaf rollers as compared to other known products, farm tank mixes and market products. Apart from this, the number of productive tillers per cluster of T1 to T5 was between 30 and 34. In particular, T2 showed a number of productive tillers per cluster of 34.4, followed by T1 (33.2) and T3 (31.2) as compared to other known products, farm tank mixes and market products. Moreover, the percentage increase in productive tillers relative to T4 was between 93 and 117.

[0559] Overall field trial summary:

[0560] The following compositions of the present invention show synergistic effects in insect pest and disease control, and also allow more fruits, flowers and grains to be produced, increase the control spectrum, and reduce the number of insecticide applications under field conditions: a combination of fluoxetine, at least one diamide insecticide and one or more insecticides; a combination of fluoxetine, at least one diamide insecticide and at least one fungicide; and a combination of fluoxetine, at least one diamide insecticide and at least one plant health additive.

[0561] Those skilled in the art can modify the method for preparing the novel synergistic composition accordingly based on the knowledge of manufacturing formulations. However, all these changes and modifications are still included in the scope of the present invention.

[0562] Before sowing, directly on the seed or after the seed pre-germination, the seed is applied. Suitable application methods especially include soil treatment, seed treatment, in-ditch application and foliar application. Soil treatment methods include spraying the soil, drip irrigation (drip application on the soil), dipping roots, tubers or bulbs, or soil injection. Seed treatment technology includes seed dressing, seed coating, seed dusting, seed soaking and seed pelleting. In-ditch application generally includes digging trenches on cultivated land, sowing in the trenches, applying the insecticidal active composition in the trenches and closing the trenches. Foliar application refers to applying the insecticidal active composition to plant leaves, for example, by spraying equipment.

[0563] The rates of application vary widely, depending upon the nature of the soil, the method of application, the crop plant, the pest to be controlled, prevailing climatic conditions, and other factors influenced by the method of application, the timing of application, and the target crop.

[0564] The present invention is applicable to protecting crops, plants, plant propagation materials (e.g. seeds) or soil or water where plants grow from attack or infestation by animal pests. Therefore, the present invention also relates to a method for protecting plants, comprising contacting crops, plants, plant propagation materials (e.g. seeds) or soil or water where plants grow from an insecticidal effective amount of the composition of the present invention to protect them from attack or infestation by animal pests.

[0565] The present invention is also applicable to preventing or controlling animal pests. Therefore, the present invention also relates to a method for preventing or controlling animal pests, which comprises contacting animal pests, their habitats, breeding grounds or food supply, or crops, plants, plant propagation materials (such as seeds), or soil, or areas, materials or environments where animal pests grow with an insecticidally effective amount of the composition of the present invention.

[0566] Examples of crops for which the insecticidal composition of the present invention can be used include, but are not limited to, cotton (Gossypium spp.), rice (Oryza sativa), wheat (Triticum aestavum), barley (Hordeum vulgare), corn (Zea mays), sorghum (Sorghum bicolor), oats (Avena sativa), pearl millet (Pennisetum glaucum), sugarcane (Saccharum officinarum), sugar beet (Beta vulgaris), soybean (Glycin max), groundnut / peanut (Arachis hypogaea), sunflower (Helianthus annuus), mustard (Brassica juncea), rapeseed (Brassica napus), sesame (Sesamum indicum), mung bean (Vigna radiata), black bean (Vigna mungo), chickpea (Cicer aritinum), cowpea (Vigna unguiculata), red gram (Red gram) (Cajanus cajan), kidney bean (Phaseolus vulgaris), lentil (Lablab purpureus), hard-shell bean (Macrotyloma uniflorum), pea (Pisum sativum), guar (Cyamopsis tetragonoloba), lentil (Lensculinaris), eggplant (Solanum melongena), cabbage (Brassica oleracea var. capitata), cauliflower (Brassica oleracea var. botrytis), okra (Abelmoschus esculentus), onion (Alliumcepa L.), tomato (Solanum lycopersicun), potato (Solanum tuberosum), sweet potato (Ipomoeabatatas), pepper (Capsicum annum), bell pepper (Capsicum annum), garlic (Allium sativum), cucumber (Cucumis sativus), cantaloupe (Cucumis melo), watermelon (Citrullus lanatus), gourd (Lagenariasiceraria), bitter melon (Momordica charantia), radish (Raphanus sativus), carrot (Dacuscarota subsp.sativus), white radish (Brassica rapa rapa), apple (Melus domestica), banana (Musa spp.), citrus (Citrus spp.), grape (Vitis vinifera), guava (Psidium guajava), mango (Mangifera indica), papaya (Carica papaya), pineapple (Ananas comosus), pomegranate (Punica granatum), sapodilla (Manilkara zapota), tea (Camellia sinensis), coffee (Coffea Arabica), turmeric (Curcuma longa), ginger (Zingiber officinale), cumin (Cuminum cyminum), black pepper (Piper nigrum), mint (Mentha spp.), rose (Rosa spp.), jasmine (Jasminum spp.), marigold (Tagetes spp.), daisy (Bellis perennis), dahlia (Dahlia hortnesis), gerbera (Gerbera jamesonii), carnation (Dianthus caryophyllus) and GMO (Genetically Modified Organism) and non-GMO traits, hybrids and conventional varieties.

[0567] Crops are to be understood as also including those crops which have been made tolerant to herbicides or classes of herbicides (e.g. ALS inhibitors, GS inhibitors, EPSPS inhibitors, PPO inhibitors, ACCase inhibitors and HPPD inhibitors) by conventional breeding methods or genetic engineering. Examples of crops which have been made tolerant to imidazolinones (e.g. imazamox) by conventional breeding methods are Summer rapeseed (canola). Crops genetically engineered to be tolerant to herbicides include, but are not limited to, glyphosate- and glufosinate-tolerant corn varieties, which are available under the trade names and Commercially available.

[0568] Crops are also to be understood as those crops which have been rendered resistant to harmful insects by genetic engineering methods, for example Bt corn (resistant to European corn borer), Bt cotton (resistant to boll weevil) and Bt potato (resistant to Colorado beetle). Bt corn includes (Syngenta Seeds). Bt toxin is a protein produced naturally by the soil bacterium Bacillus thuringiensis. EP-A-451878, EP-A-374 753, WO 93 / 07278, WO 95 / 34656, WO 03 / 052073 and EP-A-427529 describe such toxins or transgenic plants capable of synthesizing such toxins. Transgenic plants comprising one or more genes encoding insecticide resistance and expressing one or more toxins are (Corn), Yield (corn), (cotton), (cotton), (potato), and Plant crops or their seed material can be made both resistant to herbicides and resistant to insect feeding ("stacked" transgenic events). For example, seeds can have the ability to express an insecticidal Cry3 protein while being tolerant to glyphosate.

[0569] Crops are also to be understood as including those which have been obtained by conventional breeding or genetic engineering methods and contain so-called output traits, such as improved storage stability, higher nutritional value and improved flavour.

[0570] Other useful plants include turf grasses, such as those grown on golf courses, lawns, parks and roadsides, or grown commercially for lawns, and ornamental plants, such as flowers or shrubs.

[0571] The insecticide composition of the present invention can be used to control insect pests and plant parasitic nematodes. The main insect pests belong to the order Hemiptera, such as but not limited to rice leafhopper / green leafhopper (GLH) (Nephotettix nigropictus), brown rice planthopper (BPH) (Nilaparvata lugen), rice back planthopper (WBPH) (Sogatella furcifera), apple mealybug (Phenococcus aceris), bean aphid (Aphis fabae), orange aphid (Toxoptera aurantii), citrus blackscale (Saissetia oleae), cabbage aphid (Brevicoryne brassicae), false cabbage aphid (Lipaphis erysimi), citrus red scale (Citrus red scale (Aonidiella aurantii), yellow scale (Aonidiella citrine), citrus mealybug (Planococcus citri), corn leaf aphid (Rhopalosiphum maidis), aphids (Aphis gossypii), leafhoppers (Amrasca biguttula), mealybugs (Planococcus spp. and Pseudococcus spp.), cotton stink bugs (Dysdercus suturellus), whiteflies (Bemisia tabaci), cowpea aphids (Aphis crassivora), cereal aphids (Sitobion avenae), golden glow aphid (Uroleucon spp.), grape mealybug (Pseudococcus maritimus), green peach aphid (Myzus persicae), greenhouse whitefly (Trialeurodes vaporariorum), papaya mealybug (Pracoccus marginatus), pea aphid (Acyrthosiphonpisum), sugarcane mealybug (Saccharicoccussacchari), potato aphid (Myzus persicae), potato leafhopper (Empoasca fabae), cotton whitefly (Bemisia tabaci), grass bug (Lygus lineolaris), hairy apple aphid (Eriosomalanigerum), and mango leafhopper (Amritodus atkinsoni, Idioscopus spp.); Lepidoptera, such as, but not limited to, armyworm (Mythimna unipuncta), Asian rice borer (Chilo suppressalis), bean pod borer (Maruca vitrata), beet armyworm (Spodoptera exigua), black cutworm (Agrotis ipsilon), stem borer (Helicoverpa armigera), cabbage looper (Trichoplusia ni), apple moth (Cydia pomonella), croton caterpillar (Achea janata), diamond backmoth (Plutella xylostella), cabbage larvae (Pieris rapae), pink bollworm (Pectinophora gossypiella), sugarcane borer (Diatraea saccharalis), sugarcane early shoot borer (Chilo infuscatellus), tobacco armyworm (Heliothis virescens), tomato stem borer (Helicoverpa zea), velvet bean (Anticarsia rapae), gemmatalis), yellow stem borer (Scirpophaga incertulas), spotted stem borer (Earias vittella), rice leaf roller (Cnaphalocrocis medinalis), powdery stem borer (Sesamia spp.), tobacco leaf moth (Spodoptera litura); eggplant tip borer (Leucinodes orbonalis), bean pod borer (Maruca vitrata, Maruca pod borer)testulalis), armyworm (Mythimna separata), citrus leafminer (Phyllocnistis citrella), cabbage butterfly (Pieris brassicae), rice stem borer (Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata), wheat stem borer (Sesamia inferens, Sitotrogacerealella, Spilosoma obliqua), and fall armyworm (Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura), sugarcane borer (Tryporyza nivella), sharp-winged rice dream moth (Tryporyza incertulas, tomato leafminer (Tuta absoluta); Coleoptera, such as, but not limited to, apple twig borer (Amphicerus spp.), corn rootworm (Diabrotica virgifera), cucumber beetle (diabrotica balteata), pod weevil (Anthonomus grandis), grape flea beetle (Altica chalybea), grape rootworm (Fidia viticola), grape stem borer (Clytoleptus albofasciatus), radish flea beetle (horseradish flea beetle (Phyllotreta armoraciae), corn weevil (Sitophilus zeamais), northern corn rootworm (Diabrotica barberi), rice water weevil (Lissorhoptrus oryzophilus), cotton boll weevil (Anthonomus grandis), grandis), European lentil weevil (Bruchuslentis), eleven-spotted rootworm (Diabrotica semipunctata), corn rootworm (Diabroticavirgifera), rice ironclad beetle (Dicladispa armigera), Mexican bean beetle (Epilachnavarivestis), and various species of white grubs (Holotrichia bicolor, Holotrichiaconsanguinea, Holotrichia serrata, Leptinotarsa ​​decemlineata, Phyllotreta chrysocephala, Popillia japonica); Orthoptera, such as, but not limited to, Gryllotalpa spp., Locusta spp., and Schistocerca spp.; Thysanoptera, such as, but not limited to, Frankliniella spp., Thrips palmi, Thrips tabaci, and Scirtothrips dorsalis; Termitomyces (Isoptera), such as, but not limited to, Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, and Termes natalensis; Heteroptera, such as, but not limited to, Dysdercus spp. and Leptocorisa spp.; Hymenoptera, such as, but not limited to, Solenopsis spp.; Diptera, such as, but not limited to, Antherigona soccata, Dacus spp., Liriomyza spp., and Melanagromyza spp.; Acarina, such as, but not limited to, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus), Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp., Tetranychus urticae, and Tetranychus cinnabarinus.cinnabarinus); plant parasitic nematodes such as, but not limited to, root-knot nematodes (Meloidogyne incognita, Meloidogyne javanica, and other Meloidogyne species), cyst nematodes (Globodera rostochiensis, Globodera pallida, Globodera tabacum, and other Globodera species, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species), seed gall nematodes (Anguina funesta, Anguina tritici and other Anguina species), stem and leaf nematodes (Aphelenchoides besseyi, Aphelen-choides fragariae, Aphelenchoides ritzemabosi and other Aphelenchoides species), sting nematodes (Belonolaimus longicaudatus and other Belonolaimus species), pine nematodes (Bursaphelenchus xylophilus and other Bursaphelenchus species), ring nematodes (Criconema species, Criconemella species, Criconemoides species and Mesocriconema species), stem and bulb nematodes (Ditylenchus destructor), Ditylenchus dipsaci, Ditylenchus myceliophagus and other Ditylenchus species), Triatomine nematodes (Dolichodorus species), Spirochete nematodes (Helicotylenchusdihystera), Helicotylenchus multicinctus and other Helicotylenchus species, Rotylenchus robustus and other Rotylenchus species), sheath nematodes (Hemicycliophora species) and Hemicriconemoides species), Hirshmanniella species, lance nematodes (Hoplolaimus columbus, Hoplolaimus galeatus and other Hoplolaimus species), pseudo-root-knot nematodes (Nacobbus aberrans and other Nacobbus species), needle nematodes (Longidorus elongates and other Longidorus species), pin nematodes (Paratylenchus species), lesion nematodes (Pratylenchus brachyurus, Pratylenchus coffeae, Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae and other Pratylenchus species, Radinaphelenchus cocophilus and other Radinaphelenchus species), burrowing nematodes (Radopholus similis and other Radopholus species), reniform nematodes (Rotylenchulus reniformis and other Rotylenchulus species), Scutellonema species, short and thick root nematodes (Trichodorusprimitivus and other Trichodorus species, Paratrichodorus minor and other Paratrichodorus species), dwarf nematodes (Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species, and Merlinius species), citrus nematodes (Tylenchulus semipenetrans and other Tylenchulus species), Xiphinema (Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum and other Xiphinema species), and other plant parasitic nematode species.

[0572] The insecticide composition of the present invention has very good fungicidal performance and can be used to control plant pathogens such as Ascomycetes, Basidiomycetes, Chytridiomycetes, Deuteromycetes, Oomycetes, Plasmodiophoromycetes, Zygomycetes, etc.

[0573] Examples of some pathogens of fungal diseases that fall within the above general term include, but are not limited to, diseases caused by pathogens that cause powdery mildew, such as, but not limited to, Blumeria species, such as, but not limited to, Blumeria graminis, Podosphaera species, such as, but not limited to, Podosphaera leucotricha, Oidium species, such as, but not limited to, Oidium mangiferae, Sphaerotheca species, such as, but not limited to, Sphaerotheca fuliginea, Uncinula species, such as, but not limited to, Uncinula necator, Leveillula species, such as, but not limited to, Leveillula tatarica. taurica), Erysiphe species, such as but not limited to Erysiphe polygoni; diseases caused by pathogens of rust, such as but not limited to Gymnosporangium species, such as but not limited to Gymnosporangium sabinae, Hemileia species, such as but not limited to Hemileia vastatrix, Phakopsora species, such as but not limited to Phakopsora pachyrhizi and Phakopsora meibomiae, Puccinia species, such as but not limited to Puccinia graminis, Puccinia recondita or Puccinia triticina, and Puccinia stripe striiformis, Uromyces species, such as but not limited to Uromyces phaseoli; diseases caused by pathogens of smut, such as but not limited to Sporisorium species, such as but not limited to Sporisorium scitamineum, Ustilago species, such as but not limited to Ustilago maydis, Tilletia species, such as but not limited to Tilletia tritici,Ustilaginoidea species, such as but not limited to Ustilaginoidea virens; diseases caused by pathogens of ergot, such as but not limited to Claviceps species, Claviceps purpurea; diseases caused by pathogens of the oomycete group, such as but not limited to Bremia species, such as but not limited to Bremia lactucae, Peronospora species, such as but not limited to Peronospora pisi or P. brassicae, Phytophthora species, such as but not limited to Phytophthora infestans, Plasmopara species, such as but not limited to Plasmopara spp. viticola, Pseudoperonospora species, such as but not limited to Pseudoperonospora humuli or Pseudoperonospora cubensis, Pythium species, such as but not limited to Pythium ultimum; leaf spot diseases and leaf blight caused by species such as but not limited to Alternaria species, such as but not limited to Alternaria solani, Alternaria alternata and Alternaria porii, Cercospora species, such as but not limited to Cercospora arachidicola, Cladiosporum species, such as but not limited to Cladiosporium cucumerinum, Cochliobolus species, such as but not limited to Cochliobolus graminis. sativus) (conidial form: Drechslera, syn: Helminthosporium), Colletotrichum species, such as but not limited to Colletotrichum capsici, Cycloconium species, such as but not limited to Cycloconium oleaginum, Diaporthe species, such as but not limited to Diaporthe citri,Elsinoe species, such as but not limited to Elsinoe fawcettii, Gloeosporium species, such as but not limited to Gloeosporium laeticolor, Glomerella species, such as but not limited to Glomerella cingulata, Guignardia species, such as but not limited to Guignardia bidwelli, Leptosphaeria species, such as but not limited to Leptosphaeria maculans, Magnaporthe species, such as but not limited to Magnaporthe grisea, Mycosphaerella species, such as but not limited to Mycosphaerella graminearum, graminicola, Phaeosphaeria species, such as but not limited to Phaeosphaeria nodorum, Pyrenophora species, such as but not limited to Pyrenophora teres, Ramularia species, such as but not limited to Ramularia collocygni, Rhynchosporium species, such as but not limited to Rhynchosporium secalis, Septoria species, such as but not limited to Septoria septoria apii), Typhula species, such as but not limited to Typhula incarnata, Venturia species, such as but not limited to Venturia inaequalis; root and stem diseases caused by species such as but not limited to Corticium species, such as but not limited to Corticium graminearum, Fusarium species, such as but not limited to Fusarium oxysporum, Gaeumannomyces species, such as but not limited to Gaeumannomyces graminis, Rhizoctonia species, such as but not limited to Rhizoctonia solani, Tapesia species,For example, but not limited to Tapesia acuformis, Thielaviopsis species, such as, but not limited to Thielaviopsis basicola; ear and inflorescence diseases (including corn cobs) caused by species such as, but not limited to Alternaria species, such as, but not limited to Alternaria spp., Aspergillus species, such as, but not limited to Aspergillus flavus, Cladosporium species, such as, but not limited to Cladosporium spp., Claviceps species, such as, but not limited to Claviceps purpurea, Fusarium species, such as, but not limited to Fusarium culmorum, Gibberella species, such as, but not limited to Gibberella zeae (Gibberella zeae). zeae), Monographella species, such as but not limited to Monographella nivalis; diseases caused by smut fungi, such as but not limited to Sphacelotheca species, such as but not limited to Sphacelotheca reiliana, Tilletia species, such as but not limited to Tilletia caries, Urocystis species, such as but not limited to Urocystis occulta, Ustilago species, such as but not limited to Ustilagonuda; fruit rot caused by the following species, such as but not limited to Aspergillus species, such as but not limited to Aspergillus flavus, Botrytis species, such as but not limited to Botrytis cinerea cinerea, Penicillium species, such as but not limited to Penicillium expansum, Sclerotinia species, such as but not limited to Sclerotiniasclerotiorum, Verticilium species, such as but not limited to Verticilium alboatrum; seed-borne and soil-borne rots and blights and seedling diseases caused by species such as but not limited to Fusarium species,For example, but not limited to, Fusarium culmorum, Phytophthora species, such as, but not limited to, Phytophthora cactorum, Pythium species, such as, but not limited to, Pythium ultimum, Rhizoctonia species, such as, but not limited to, Rhizoctonia solani, Sclerotium species, such as, but not limited to, Sclerotium rolfsii; canker, gall and witches' broom diseases caused by species such as, but not limited to, Nectria species, such as, but not limited to, Nectria galligena; wilt caused by species such as, but not limited to, Monilinia species, such as, but not limited to, Monilinia sclerotiorum laxa); leaf, flower and fruit deformations caused by species such as but not limited to Taphrina species, such as but not limited to Taphrina deformans; wood deterioration caused by species such as but not limited to Esca species, such as but not limited to Phaemoniella clamydospora; flower and seed diseases caused by species such as but not limited to Botrytis species, such as but not limited to Botrytis cinerea; plant tuber diseases caused by species such as but not limited to Rhizoctonia species, such as but not limited to Rhizoctonia solani; diseases caused by bacterial pathogens such as but not limited to Xanthomonas species, such as but not limited to Xanthomonas campestris pv. oryzae), Pseudomonas species, such as but not limited to Pseudomonas syringae pv. lachrymans, and Erwinia species, such as but not limited to Erwinia amylovora.

Claims

1. A fluoxathiocarbamide composition comprising: A) 1 to 20 w / w% of fluoxathiocarb or an agrochemically acceptable salt thereof; B) at least one or more insecticides selected from diamides in an amount of 1 to 20 w / w%; and C) at least one or more compounds selected from the group consisting of pesticides, fungicides and plant health additives in an amount of 0.001 to 60 w / w%, and an agrochemically acceptable excipient.

2. The oxazolidinone amide composition according to claim 1, wherein B) The insecticide is selected from the group consisting of chlorantraniliprole, cyantraniliprole, cyclobromofenamide, tetrazoline, tetrazoline, chlorpyrifos, cyantraniliprole, flubendiamide, flufenamid, and thiofenamid.

3. The fluoxazole amide composition according to claim 3, wherein The insecticide of compound B is present in the range of 2% to 20%.

4. The fluoxathiocarbamide composition according to claim 1, wherein The insecticide used for compound C is selected from avermectin, avermectin benzoate, tolfenpyrad, pyrifoquinoxaline, lambda cyhalothrin, fipronil, fenpyroximate, hexythiazox, etoxazole, diafenthiuron, methoxyfenozide, spinosad, indoxacarb, biprofenopyr, flonicamid, pyriproxyfen, bifenthrin, deltamethrin, thiamethoxam and dinotefuran.

5. The fluorooxazole amide composition according to claim 5, wherein The insecticide of compound C is present in the range of 1.5% to 20%.

6. The fluoxathiazole amide composition according to claim 1, wherein The fungicide used for compound C is selected from pyraclostrobin, fluopyraclostrobin, azoxystrobin and difenoconazole.

7. The fluoxazole amide composition according to claim 7, wherein The fungicide of compound C is present in the range of 10% to 30%.

8. The fluoxazolidinone amide composition according to claim 1, wherein The plant health care additive is selected from zinc oxide, campesterol, ascophyllum nodosum, salicylic acid, orthosilicic acid, limanarin, amino acids, fulvic acid, humic acid, gibberellin, mepiquat, paclobutrazol and stigmasterol.

9. The fluorooxazole amide composition according to claim 9, wherein The amino acid is glycine.

10. The fluoxazolidinone amide composition according to claim 9, wherein The plant health additive is present in the range of 0.04% to 10%.

11. The fluoxathiocarbamide composition according to claim 1, wherein The agrochemically acceptable excipient is selected from dispersants, antifreeze agents, defoamers, wetting agents, suspension aids and carriers, antimicrobial agents, thickeners, colorants, rapid coating agents or stickers, polymers, disintegrants, oil additives, buffers and solvents.

12. The fluoxazolidinone amide composition according to claim 12, wherein The agrochemically acceptable excipient is present in the range of 0.1% to 99% by weight of the total composition.

13. The fluoxathiocarbamide composition according to claim 1, wherein The composition is in the form of an oil dispersion (OD), a suspension concentrate (SC), a suspoemulsion (SE), a water dispersible granule (WG or WDG), and a mixed preparation of a capsule suspension CS and SC (ZC).

14. The fluorooxazole amide composition according to claim 1 or 14, wherein The wetting agent for the oil dispersant (OD) is selected from ethylene oxide / propylene oxide block copolymers, polyarylphenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates and mixtures thereof.

15. The fluorooxazole amide composition according to claim 1 or 14, wherein The wetting, diffusing and penetrating agent for oil dispersant (OD) is selected from silicone surfactant trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methylpolysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyoxyalkylene modified heptamethyltrisiloxane, polyether modified polysiloxane, which may or may not be in modified form, may be in liquid or powder form and mixtures thereof.

16. The fluorooxazole amide composition according to claim 1 or 14, wherein Emulsifiers for oil dispersants (OD) are selected from castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulfosuccinates, calcium salts of dodecylbenzene sulfonates, alkylammonium salts of alkylbenzene sulfonates, alkyl sulfosuccinates, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkylphenols, polyoxyethylene sorbitan monolaurate and mixtures thereof.

17. The fluorooxazole amide composition according to claim 1 or 14, wherein The dispersant used for the oil dispersant (OD) is selected from the group consisting of alkyl sulfonates, alkylbenzene sulfonates, alkylaryl sulfonates, alkylphenol alkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylated alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohol alkoxylates, alkoxylated alcohols (e.g., n-butyl alcohol polyglycol ether), block copolymers (e.g., ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, polyolefin condensates. Salts of polyols, sodium lignin sulfonate, sodium polycarboxylate, EO / PO-based copolymers, phenol sulfonate, sodium methyl oleyl taurate, styrene acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine-polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide, and mixtures thereof.

18. The fluorooxazole amide composition according to claim 1 or 14, wherein The stabilizer for the oil dispersant (OD) is selected from the group consisting of hectorite clay, magnesium aluminum silicate, bentonite clay, silica, attapulgite clay, and mixtures thereof.

19. The fluorooxazole amide composition according to claim 1 or 14, wherein The defoamer for oil dispersant (OD) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoam emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, and mixtures thereof.

20. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The antifreeze agent used for the oil dispersant (OD) is selected from ethylene glycol, propylene glycol, glycerol or urea, glycols (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerol, urea, magnesium sulfate heptahydrate, sodium chloride; the preservative is 1,2-benzisothiazolin-3(2H)-one (sodium salt), sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and a mixture thereof.

21. The fluorooxazole amide composition according to claim 1 or 14, wherein The solvent for the oil dispersant (OD) is selected from vegetable oils (plant, seed or tree) or alkylates or ethoxylates or esters thereof; the alkylated vegetable oil can be methylated vegetable oil or ethylated vegetable oil; the vegetable oils include olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil; alkyl esters of vegetable oils; methyl, ethyl, propyl or butyl esters of vegetable oils, methylated seed oils, polyoxyalkylene-modified polydimethylsiloxane ... Methylsiloxane alkylphenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl ester, rapeseed oil butyl ester, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cottonseed oil methyl ester, cottonseed oil ethyl ester, cottonseed oil butyl ester, cottonseed oil propyl ester, tall oil fatty acid esters - animal fat methyl ester, animal fat ethyl ester, animal fat propyl ester, biodiesel, mineral oil (aromatic solvents, isoparaffins, alkaline solvents), fatty acid amides (e.g. C1-C3 amines, alkylamines or C6-C 18 carboxylic acid alkanolamines), fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyalate, alkylbenzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkyl amides and diamides, diene carbonates, ketones and alcohols; the above oil-based carriers / diluents can be used alone or in mixtures thereof.

22. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The cosolvent for the oil dispersant (OD) is selected from cyclohexanone, acetophenone, NMP, dimethyl sulfoxide, benzyl alcohol, butanol, N-octanol, N-propanol, 2-ethylhexanol, tetrahydrofurfuryl alcohol, isophorone, fatty acid dimethylamide, 2-hexylethyl lactate, propylene carbonate and mixtures thereof.

23. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The wetting agent for suspension concentrate (SC) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, polyalkoxylated butyl ethers, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates, silicone surfactants (as wetting diffusion penetrants): trisiloxane ethoxylates, polydimethylsiloxanes, polyoxyethylene methylpolysiloxanes, polyoxyalkylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, heptamethyltrisiloxane, modified forms: polyoxyalkylene-modified heptamethyltrisiloxane, polyether-modified polysiloxanes, polyoxyalkylene-modified trisiloxanes, polyoxyalkylene-modified polydimethylsiloxanes, trisiloxane ethoxylates, polyoxyethylene methylpolysiloxanes, polyether polymethylsiloxane copolymers, polyether-modified polysiloxanes, which may or may not be in modified form, in liquid or powder form, and mixtures thereof.

24. The fluoxazolidinone amide composition according to claim 1 or 14, wherein Dispersants for suspension concentrates (SC) are selected from sodium naphthalenesulfonate formaldehyde condensate, alkylated naphthalenesulfonates (sodium salt), sodium salt of naphthalenesulfonic acid condensate, sodium lignin sulfonate, sodium polycarboxylate, EO / PO based copolymers, phenol sulfonates, sodium methyl oleyl taurate, styrene acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide, and mixtures thereof.

25. The fluorooxazole amide composition according to claim 1 or 14, wherein The suspending agent used in the suspension concentrate (SC) is selected from magnesium aluminum silicate, bentonite clay, silica, attapulgite clay and mixtures thereof.

26. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The defoamer for suspension concentrate (SC) is selected from silicone oil, organosilicon compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoam emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, and mixtures thereof.

27. The fluorooxazole amide composition according to claim 1 or 14, wherein The antifreeze agent used for suspension concentrate (SC) is selected from ethylene glycol, propylene glycol, glycerol or urea, glycols (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerol, urea, magnesium sulfate heptahydrate, sodium chloride and mixtures thereof.

28. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The preservative used in the suspension concentrate (SC) is selected from 1,2-benzisothiazolin-3(2H)-one (sodium salt), sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one and mixtures thereof.

29. The fluorooxazole amide composition according to claim 1 or 14, wherein The thickener used for the suspension concentrate (SC) is selected from the group consisting of xanthan gum, PVK, carboxymethyl cellulose, polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, gum arabic and mixtures thereof.

30. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The humectant used in the suspension concentrate (SC) is selected from urea, humic acid, glycerol, lactose and mixtures thereof.

31. The fluorooxazole amide composition according to claim 1 or 14, wherein The solvent for the suspension emulsion (SE) is selected from water, water-soluble alcohols and dihydroxy alcohol ethers; water-soluble alcohols or lower alcohols (1 to 4 carbon atoms); methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol; macromolecular alcohols; polyethylene glycol, sorbitol, glucitol, dihydroxy alcohol ethers; dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers; examples of dihydroxy alcohol alkyl ethers include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether and dipropylene glycol ethyl ether; examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether and mixtures thereof; hydrocarbons include n-pentane, hexane, cyclohexane, methylcyclohexane, heptane, isooctane, benzene, toluene, xylene, isophorone, ester solvents such as methyl oleate, C6-C 16 Dimethylamides and morpholineamide derivatives of fatty acids, monoolefin carbonates such as ethylene carbonate, propylene carbonate and butylene carbonate, dimethyl sulfoxide (DMSO), 2-ethylhexanol, n-butanol, n-alkylpyrrolidone, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic and / or aliphatic hydrocarbons, one or more dimethylamides, for example C8-dimethylamide, C 10 -dimethylamide, C 12 - dimethyl amide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methyl pyrrolidone (NMP); dimethylformamide (DMF); dimethyl isosorbide (DMI); isophorone; acetophenone; 1,3-dimethyl-2-imidazolidinone; lactic acid esters; dimethyl carbonate and diethyl carbonate; alcohols including methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol and tert-butanol; methyl L-lactate, 2-ethylhexyl L-lactate, ethyl L-lactate, n-butyl L-lactate, octylphenol ethoxylate and mixtures thereof.

32. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The emulsifier used for the suspoemulsion (SE) is selected from dodecylbenzene sulfonate, calcium salt or amine salt, other C 11 -C 16 Sulfonates of alkylbenzenes, alkyl ether sulfates, alkylphenol ether phosphates and ester phosphates; nonionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated castor oils, fatty acid esters, sorbitol and its ethoxylated derivatives, ethoxylated amines, condensates of glycerol; anionic and cationic emulsifiers such as cationic amines, optionally in combination with alkyl sulfonates or ether sulfonates or ether phosphates, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol (tristyrylphenol with 16 mol EO), tristyrylphenol-polyethylene glycol ether-phosphates, fatty acid esters of sorbitol and its ethoxylated derivatives; ethoxylated amines, condensates of glycerol; C 11 -C 16 Sulfonated alkylbenzenes and salts thereof within the scope of the present invention; alkyl ether sulfates; alkyl ether phosphates; alkylphenol ether phosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulfated ethers of ethoxylated tristyrylphenol; or anionic and cationic systems in which cationic amines are present in combination with alkyl sulfonates, alkyl ether sulfonates, ether sulfates or ether phosphates (e.g., alkyl ether phosphates), nonylphenol polyethoxyethanol, castor oil polyglycol ether, polyadducts of ethylene oxide and polypropylene, tributylphenoxypolyethoxyethanol, octylphenoxypolyethoxyethanol and mixtures thereof.

33. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The stabilizer used in the suspoemulsion (SE) is selected from butylated hydroxytoluene (BHT) and epoxidized soybean oil (ESBO), epichlorohydrin and mixtures thereof.

34. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The antifreeze agent used in the suspoemulsion (SE) is selected from ethylene glycol, propylene glycol, glycerol or urea, glycols (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerol, urea, magnesium sulfate heptahydrate, sodium chloride and mixtures thereof.

35. The fluorooxazole amide composition according to claim 1 or 14, wherein The defoamer for suspoemulsion (SE) is selected from silicone oil, silicone compound, C 10 ~C 20 Saturated fatty acid compounds or C8~C 10 Fatty alcohol compounds, silicone antifoam emulsions, dimethylsiloxanes, polydimethylsiloxanes, vegetable oil-based antifoaming agents, animal fat-based fatty acids, polyoxyalkylene-modified polydimethylsiloxanes, and mixtures thereof.

36. The fluoxazole amide composition according to claim 1 or 14, wherein The suspending agent used in the suspoemulsion (SE) is selected from the group consisting of magnesium aluminum silicate, bentonite clay, silica, silicon dioxide, attapulgite clay, and mixtures thereof.

37. The fluoxazolidinone composition according to claim 1 or 14, wherein the wetting agent for the suspoemulsion (SE) is selected from ethylene oxide / propylene oxide block copolymers, polyaryl phenyl ether phosphates, ethoxylated fatty alcohols, dioctyl sodium sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates, octylphenol ethoxylates, alkylphenol ethoxylates and mixtures thereof.

38. The fluorooxazole amide composition according to claim 1 or 14, wherein The wetting, diffusing and penetrating agent for the suspoemulsion (SE) is selected from the group consisting of silicone surfactants trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methylpolysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyoxyalkylene-modified heptamethyltrisiloxane, heptamethyltrisiloxane ethoxylate, polyether-modified polysiloxane, 10 moles of ethylene oxide adduct of octylphenol, which may or may not be in modified form, may be in liquid or powder form and mixtures thereof.

39. The fluorooxazole amide composition according to claim 1 or 14, wherein Preservatives used in suspoemulsions (SE) are selected from propionic acid and its sodium salts, sorbic acid and its sodium or potassium salts, benzoic acid and its sodium salts, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate and biocides such as sodium benzoate, 1,2-benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isoxazolin-3-one, potassium sorbate, p-hydroxybenzoates and mixtures thereof.

40. The fluoxazolidinone amide composition according to claim 1 or 14, wherein Thickeners for suspoemulsions (SE) are selected from thickeners, gelling agents and anti-settling agents, water-insoluble particles and water-soluble polymers, clays and silica, montmorillonite, bentonite, magnesium aluminum silicate, attapulgite, natural extracts from seeds and 15 types of seaweed, synthetic derivatives of cellulose and mixtures thereof; examples of these types of materials include, but are not limited to, guar gum, locust bean gum, carrageenan, xanthan gum, alginates, methylcellulose, sodium carboxymethylcellulose (SCMC), hydroxyethylcellulose (HEC) and mixtures thereof; anti-settling agents are based on modified starches, polyacrylates, polyethylene 20 alcohol and polyethylene oxide and mixtures thereof.

41. The fluoxazolidinone composition of claim 1 or 14, wherein the dispersant for the suspoemulsion (SE) is selected from polyesters, polyamides, polycarbonates, polyureas and polyurethanes, acrylic polymers, acrylic graft copolymers, styrene copolymers, butadiene copolymers, polysaccharides, starch and cellulose derivatives, vinyl alcohol, vinyl acetate and vinyl pyrrolidone polymers and copolymers, polyethers, epoxy resins, phenolic resins and melamine resins, polyolefins, and copolymers and mixtures thereof are defined; examples of polymers are acrylate polymers, poly(methacrylates), poly(ethyl methacrylate), poly(methyl methacrylate), acrylate copolymers and styrene-acrylic copolymers, poly(styrene-co-maleic anhydride), cellulosic polymers, ethyl cellulose, cellulose acetate, cellulose acetate butyrate, acetylated monoglycerides, acetylated diglycerides and acetylated triglycerides, poly(vinyl pyrrolidone), vinyl acetate polymers and copolymers, poly(ethylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more thereof; biodegradable polymers Examples of the dispersant are biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanones, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly(n-amyl methacrylate), wood rosin, polyanhydrides, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters, polyhydroxybutyrates, and mixtures thereof; examples of the dispersant are alkylated naphthalene sulfonates (sodium salts), sodium salts of naphthalenesulfonic acid condensates, sodium salts of alkyl naphthalenesulfonic acids. , sodium lignin sulfonate, sodium polycarboxylate, EO / PO block copolymer, phenol sulfonate, sodium methyl oleyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide copolymer, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyrylphenol-polyethylene glycol ether-phosphate, tristyrylphenol with 16 moles of EO, tristyrylphenol-polyethylene glycol ether-phosphate, oleyl polyethylene glycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyethylene glycol ether with 9 to 10 moles of ethylene oxide, and mixtures thereof.

42. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The buffer for the suspoemulsion (SE) is selected from calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphate, carbonated calcium phosphate, amine monomers, lactate dehydrogenase, magnesium hydroxide and mixtures thereof.

43. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The humectant used in the suspoemulsion (SE) is selected from urea, humic acid, glycerol, lactose and mixtures thereof.

44. The fluoxazolidinone amide composition according to claim 1 or 14, wherein The dispersant used in wettable granules (WG) is selected from sodium polycarboxylate (sodium polyacrylate), naphthalenesulfonic acid, sodium salt condensate with formaldehyde, polyalkoxylated alkylphenol, naphthalenesulfonic acid formaldehyde condensate, methylnaphthalene-formaldehyde condensate sodium salt, naphthalene condensate, lignin sulfonate, calcium lignin sulfonate, sodium lignin sulfonate, alkylnaphthalene sulfonate (sodium salt), alkylnaphthalene sulfonate and mixtures thereof.

45. The fluorooxazole amide composition according to claim 1 or 14, wherein The wetting agent for wettable granules (WG) is selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonates (sodium salt), a mixture of isomers of dibutylnaphthalene sulfonic acid sodium salt, sodium diisopropylnaphthalene sulfonate, sodium dodecyl sulfate, dioctyl sulfate, alkylnaphthalene sulfonates, phosphates, sulfosuccinates, nonionics such as tridecyl alcohol ethoxylates, alkyl or alkaryl sulfonates, alkylbenzene sulfonates, α-olefin sulfonates and alkylnaphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphates, alkyl polysaccharides, di- or monoalkyl sulfosuccinate derivatives, α-olefin sulfonates, alkylnaphthalene sulfonates, dialkyl sulfosuccinates, butylnaphthalene sulfonates, dibutylnaphthalene sulfonates, isopropylnaphthalene sulfonates and diisopropylnaphthalene sulfonates, C 12 Alkylbenzene sulfonate or C 10 -C 16 Alkylbenzene sulfonate, silicone surfactant trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methylpolysiloxane, polyoxyalkylene methylpolysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyoxyalkylene modified heptamethyltrisiloxane, polyether modified polysiloxane, which may or may not be in modified form, may be in liquid or powder form and mixtures thereof.

46. ​​The fluoxazolidinone amide composition according to claim 1 or 14, wherein The defoaming agent used in wettable granules (WG) is selected from polydimethylsiloxanes and mixtures thereof.

47. The fluorooxazole amide composition according to claim 1 or 140, wherein Carriers for wettable granules (WG) are selected from china clay, silica, anhydrous lactose, ammonium sulfate, anhydrous sodium sulfate, corn starch, urea, EDTA, urea-formaldehyde resin, diatomaceous earth, kaolin, bentonite, mortar, fuller's earth, attapulgite clay, tree trunks, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesium oxide, magnesium oxide, magnesium sulfate, sodium chloride, gypsum, calcium sulfate, pyrophyllite, silicates and silica gel; fertilizers, such as ammonium sulfate, ammonium phosphate, ammonium nitrate and urea; natural products of plant origin, such as cereal grains and flours, bark powder, wood powder, nut shell powder and cellulose powder; and synthetic polymer materials, ground or powdered plastics and resins, bentonite, zeolite, titanium dioxide, iron oxides and hydroxides, aluminum oxides and hydroxides, or organic materials, such as bagasse, charcoal, or synthetic organic polymers, and mixtures thereof.

48. The fluorooxazole amide composition according to claim 1 or 14, wherein The humectant used in wettable granules (WG) is selected from humic acid, glycerol, lactose, anhydrous sodium sulfate or a mixture thereof.

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