Tinnitus sound stimulation signal generation method and device and tinnitus test and sound treatment system

Abstract

The embodiment of the invention provides a tinnitus sound stimulation signal generation method and device and a tinnitus test and sound treatment system, and relates to the technical field of medical treatment. The tinnitus sound stimulation signal generation method comprises the following steps: acquiring desensitization test data obtained by a subject through a desensitization test at a test frequency point; wherein the desensitization test of each test frequency point adopts a test sound of a corresponding frequency and a specified playing rhythm; based on the tinnitus condition of the subject, obtaining reference desensitization data matched with the subject; based on the desensitization test data and the reference desensitization data of the subject, energy adjustment parameters of the subject are determined, and the energy adjustment parameters at least comprise energy adjustment values of the test frequency points; and adjusting sound energy of the preset sound stimulation signal according to the energy adjustment parameter of the subject to obtain a target sound stimulation signal matched with the subject. According to the invention, different personalized sound stimulation signals can be generated for subjects with different tinnitus conditions.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, and in particular to a method and device for generating a sound stimulation signal for tinnitus, and a testing and sound treatment system. Background Art

[0002] Tinnitus is a common auditory abnormality characterized by the perception of sound in the absence of external sound stimulation. It is usually described as ringing, buzzing, hissing or whistling in the ears or head. It can be intermittent, continuous or recurrent. The degree of pain varies from person to person, ranging from mild annoyance to serious impact on quality of life and even leading to suicidal tendencies. The causes of tinnitus include noise, hearing loss, ototoxic drugs, ear infections, and other neurological or cardiovascular diseases. The pathophysiological characteristics of tinnitus are complex. It is generally believed that changes in neuroplasticity in the auditory peripheral and central nervous systems cause abnormal neural activity, resulting in the erroneous perception of sound in the absence of actual auditory signals.

[0003] Although the pathogenesis of tinnitus has not been fully elucidated, increasing evidence suggests that tinnitus is not just a local auditory problem, but involves widespread dysfunction of the central nervous system. These dysfunctions include overexcitation of the auditory cortex, abnormal activation of the attention network, dysregulation of the default network, and involvement of the limbic system. In addition, tinnitus patients often have emotional disorders such as anxiety and depression, suggesting dysfunction of brain areas related to emotion regulation.

[0004] At present, the commonly used tinnitus treatments are mainly masking therapy and sound therapy, which can reduce and relieve tinnitus symptoms; but these tinnitus treatments usually use fixed and identical sounds to stimulate patients. However, different patients have individual differences in their responses to sound stimulation, which will make the treatment effects vary greatly from patient to patient, resulting in some patients being unable to achieve good tinnitus treatment effects. Summary of the invention

[0005] The object of the present invention is to provide a method and device for generating a sound stimulation signal for tinnitus, a test and sound therapy system, which can determine an energy adjustment parameter matching the subject's tinnitus condition based on the desensitization test data of the subject in combination with reference desensitization data matching the subject's tinnitus condition, and then perform energy adjustment on a preset sound stimulation signal based on the energy adjustment parameter to obtain a target sound stimulation signal suitable for the subject; thereby, different personalized sound stimulation signals can be generated for subjects with different tinnitus conditions, so that subjects with different tinnitus conditions can all obtain better tinnitus treatment effects through suitable sound stimulation signals.

[0006] To achieve the above-mentioned purpose, the present invention provides a method for generating a sound stimulation signal for tinnitus, comprising: obtaining desensitization test data obtained by a subject at a test frequency point through a desensitization test; wherein the number of the test frequency point is at least one, and the desensitization test of each test frequency point adopts a test sound of a corresponding frequency and a specified playback rhythm; based on the tinnitus condition of the subject, obtaining reference desensitization data matching the subject; based on the desensitization test data of the subject and the reference desensitization data, determining an energy adjustment parameter of the subject, the energy adjustment parameter at least including: an energy adjustment value of the test frequency point; adjusting the sound energy of a preset sound stimulation signal according to the energy adjustment parameter of the subject to obtain a target sound stimulation signal matching the subject.

[0007] The present invention also provides a desensitization test system, comprising: a masking test module, used to obtain the minimum masking threshold of the subject at a test frequency point; the number of the test frequency point is at least one; a test sound generation module, used to generate a test sound used by the subject in the desensitization test at each test frequency point; the desensitization test at each test frequency point uses a test sound of a corresponding frequency, whose loudness is above the minimum masking threshold of the subject at the test frequency point, and has a specified playback rhythm; a sound output device, used to play the test sound of the desensitization test; a data acquisition module, used to collect the desensitization test data of the subject at each test frequency point; the desensitization test data of each test frequency point is used to indicate the change in tinnitus of the subject after the corresponding desensitization test.

[0008] The present invention also provides a device for generating a sound stimulation signal for tinnitus, comprising: a first acquisition module, used to obtain desensitization test data obtained by a desensitization test on a subject at a test frequency point; a second acquisition module, used to obtain the tinnitus condition of the subject; a data processing module, which is respectively communicated with the first acquisition module and the second acquisition module; the data processing module is configured to execute the method for generating a sound stimulation signal for tinnitus as described above.

[0009] The present invention also provides a sound therapy system for tinnitus, comprising: a central processing module and a sound output device; the central processing module is used for the above-mentioned sound stimulation signal generation method for tinnitus to obtain a target sound stimulation signal for output to a subject; the central processing module is also used to control the sound output device to play a corresponding sound based on the target sound stimulation signal.

[0010] The present invention also provides a computer-readable storage medium, which is a non-volatile storage medium or a non-transient storage medium, on which a computer program is stored. When the computer program is executed by a processor, the steps of the method for generating a sound stimulation signal for tinnitus as described above are executed.

[0011] In one embodiment, the step of obtaining the desensitization test data obtained by the subject through the desensitization test at the test frequency point includes:

[0012] Selecting at least one preset frequency point from each preset frequency point as a test frequency point of the subject;

[0013] Collecting the minimum masking threshold of tinnitus of the subject at each of the test frequency points;

[0014] Adding a set value to the minimum masking threshold of tinnitus at each test frequency point as the loudness of the test sound at the test frequency point;

[0015] During the desensitization test at each test frequency point, the test sound corresponding to the test frequency point is played according to the specified playback rhythm; wherein the specified playback rhythm is within the range of 35-45 Hz;

[0016] The desensitization test data of the subject at each of the test frequency points is collected, and the desensitization test data of each of the test frequency points is used to indicate the change of tinnitus of the subject after the corresponding desensitization test.

[0017] In one embodiment, the test sound used by the subject during the desensitization test has any one or more of the following characteristics:

[0018] The test sound is a narrowband sound or a pure tone at a frequency corresponding to the current test frequency point;

[0019] The loudness of the test sound is 5-15 dB above the minimum masking threshold of tinnitus of the subject at the corresponding test frequency point;

[0020] The specified playing rhythm of the test sound is 40 Hz.

[0021] In one embodiment, the desensitization test data includes a desensitization amplitude and a desensitization time.

[0022] In one embodiment, the desensitization test data further includes a desensitization score; the desensitization score is calculated and determined based on the desensitization amplitude and the desensitization time.

[0023] In one embodiment, the selecting at least one preset frequency point from the preset frequency points as the test frequency point of the subject includes any one or more of the following:

[0024] According to the tinnitus frequency of the subject, selecting a preset frequency point matching the tinnitus frequency as a test frequency point;

[0025] Selecting several preset frequency points near the subject's tinnitus frequency as test frequency points;

[0026] At least one preset frequency point is selected from each of the low frequency, the medium frequency and the high frequency as a test frequency point.

[0027] In one embodiment, the step of obtaining reference desensitization data matching the subject based on the tinnitus condition of the subject includes:

[0028] According to the tinnitus frequency, obtaining reference desensitization data of a target group matching the subject from a pre-constructed desensitization database;

[0029] The step of determining the energy regulation parameters of the subject based on the desensitization test data of the subject and the reference desensitization data includes:

[0030] The energy regulation parameters of the subject are determined based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point.

[0031] In one embodiment, the step of determining the energy regulation parameters of the subject based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point includes:

[0032] Evaluating the desensitization test data of the subject at each of the preset frequency points according to the desensitization test data of the subject at each of the test frequency points and the reference desensitization data of the target group at each of the preset frequency points;

[0033] According to the desensitization test data of the subject at each of the preset frequency points, obtaining the desensitization test data of the subject at each frequency point within a set frequency range, wherein the set frequency range includes all of the preset frequency points;

[0034] The desensitization test data of the subject at each frequency point within the set frequency range is compared with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database to obtain the energy regulation parameters of the subject, wherein the energy regulation parameters include: energy regulation values ​​at each frequency point within the set frequency range.

[0035] In one embodiment, the step of evaluating the desensitization test data of the subject at each of the preset frequency points according to the desensitization test data of the subject at each of the test frequency points and the reference desensitization data of the target group at each of the preset frequency points comprises:

[0036] Acquire reference desensitization data of the target group at each of the preset frequency points from the desensitization database, wherein the reference desensitization data includes a reference desensitization score;

[0037] For each of the preset frequency points except the test frequency point, based on the desensitization score of the subject at the test frequency point and the reference desensitization score of the target group at the preset frequency point, the desensitization score of the subject at each of the preset frequency points is evaluated.

[0038] In one embodiment, after acquiring the reference desensitization data of the target group at each of the preset frequency points from the desensitization database, the method further includes:

[0039] Obtaining a desensitization score deviation between the subject and the target group at each test frequency point, the desensitization score deviation being a difference between the desensitization score of the subject and a reference desensitization score of the target group;

[0040] After evaluating the desensitization score of the subject at each of the preset frequency points except the test frequency point based on the desensitization score of the subject at the preset frequency point and the reference desensitization score of the target group at the preset frequency point, the method further includes:

[0041] For each of the preset frequency points except the test frequency point, the desensitization score of the assessed subject at each of the preset frequency points is adjusted based on the deviation of the desensitization score between the subject and the target group at each of the test frequency points.

[0042] In one embodiment, the step of comparing the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database to obtain the energy regulation parameter of the subject includes:

[0043] Obtaining an average desensitization score of the target group at each of the preset frequency points based on the desensitization database;

[0044] Based on the average desensitization score of the target group at each of the preset frequency points, obtaining a baseline desensitization score of the target group at each frequency point within a set frequency range;

[0045] Based on the desensitization score of the subject at each of the preset frequency points, obtaining the desensitization score of the subject at each frequency point within the set frequency range;

[0046] Based on the desensitization score of the subject at each frequency point within the set frequency range and the baseline desensitization score of the target group at each frequency point within the set frequency range, a score difference between the desensitization score of the subject at each frequency point within the set frequency range and the baseline desensitization score of the target group is obtained by comparison;

[0047] The energy regulation parameter of the subject is determined according to the score difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group; wherein, if the score difference is greater than a first set value, the sound energy value of the corresponding frequency point is increased; if the score difference is lower than a second set value, the energy value of the sound at the corresponding frequency point is reduced; wherein, the first set value is greater than or equal to 0, and the second set value is less than or equal to 0.

[0048] In one embodiment, obtaining the desensitization score of the subject at each frequency point within the set frequency range based on the desensitization score of the subject at each preset frequency point includes:

[0049] Based on the desensitization score of the subject at each of the preset frequency points and the reference desensitization score of the target group at the preset frequency point, combined with the first score weight of the subject and the second score weight of the target group, the desensitization score of the subject at each frequency point within the set frequency range is obtained.

[0050] In one embodiment, the process of constructing the desensitization database includes:

[0051] Collect desensitization test data of patients with different tinnitus frequencies at each preset frequency point; the desensitization test data includes desensitization time and desensitization amplitude;

[0052] According to the desensitization time and desensitization amplitude of each patient at each preset frequency point, the desensitization score corresponding to each patient at each preset frequency point is calculated;

[0053] The collected tinnitus frequency of each patient, the desensitization time of each preset frequency point, the desensitization amplitude, and the desensitization score are stored.

[0054] In one embodiment, the desensitization score of each frequency point is the product of the corresponding desensitization amplitude and the desensitization time; or the desensitization score of each frequency point is the result obtained by normalizing or standardizing the product of the corresponding desensitization amplitude and the desensitization time.

[0055] In one embodiment, after obtaining the target stimulus sound, the method further includes:

[0056] The target sound stimulation signal is modulated according to the specified playback rhythm to serve as the final output target sound stimulation signal; the specified playback rhythm is within the range of 35-45 Hz.

[0057] Through the method and device for generating a sound stimulation signal for tinnitus provided in the present application, a personalized sound signal with better desensitization effect can be customized for tinnitus patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0058] Figure 1is a specific flow chart of the method for generating a sound stimulation signal for tinnitus according to the first embodiment of the present invention;

[0059] Figure 2 yes Figure 1 A specific flow chart of step 101 of the method for generating a sound stimulation signal for tinnitus;

[0060] Figure 3 yes Figure 1 A specific flow chart of step 103 of the method for generating a sound stimulation signal for tinnitus;

[0061] Figure 4 is a schematic diagram of a frequency-desensitization score curve of a subject in an embodiment of the present application;

[0062] Figure 5 It is a schematic diagram of a frequency-desensitization score curve and an average score reference line of another subject in another embodiment of the present application. DETAILED DESCRIPTION

[0063] The following will be described in detail with reference to the accompanying drawings to provide a clearer understanding of the purpose, features and advantages of the present invention. It should be understood that the embodiments shown in the accompanying drawings are not intended to limit the scope of the present invention, but are only intended to illustrate the essential spirit of the technical solution of the present invention.

[0064] In the following description, certain specific details are set forth for the purpose of illustrating various disclosed embodiments to provide a thorough understanding of the various disclosed embodiments. However, those skilled in the relevant art will recognize that the embodiments may be practiced without one or more of these specific details. In other cases, well-known devices, structures, and techniques associated with the present application may not be shown or described in detail to avoid unnecessarily obscuring the description of the embodiments.

[0065] Unless the context requires otherwise, throughout the specification and claims, the word "comprise" and variations such as "include" and "have" should be construed in an open, inclusive sense, ie, should be interpreted as "including, but not limited to."

[0066] References throughout the specification to "one embodiment" or "an embodiment" indicate that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of "in one embodiment" or "in an embodiment" in various places throughout the specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any manner in one or more embodiments.

[0067] As used in this specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. It should be noted that the term "or" is generally employed in its sense including "or / and" unless the context clearly dictates otherwise.

[0068] In the following description, in order to clearly show the structure and working mode of the present invention, many directional words will be used for description, but the words "front", "back", "left", "right", "outside", "inside", "outward", "inward", "up", "down", etc. should be understood as convenient terms and should not be understood as restrictive terms.

[0069] The first embodiment of the present invention relates to a method for generating a sound stimulation signal for tinnitus, which can be applied to a sound treatment system for tinnitus. The sound treatment system for tinnitus includes: a central processing module and a sound output device. The central processing module can be a conventional processor, a microcontroller, etc., and the sound output device can be a wearable headset or a speaker. The central processing module and the sound output device can be wired or wirelessly connected. After the central processing module executes the sound stimulation signal generation method of this embodiment, it can generate a target sound stimulation signal adapted to the tinnitus condition of the subject, and control the sound output device to output a corresponding stimulation sound based on the target sound stimulation signal; further, before controlling the sound output device to output the corresponding stimulation sound, the target sound stimulation signal can be modulated to a specified playback rhythm, and the specified playback rhythm is within the range of 35-45 Hz, for example, a 40 Hz rhythm, because the 40 Hz sound stimulation can regulate brain nerve activity and can reduce tinnitus, and the target sound stimulation signal is related to the tinnitus condition of the subject, so that the sound stimulation of the 40 Hz rhythm finally output can be adapted to the individual condition of the subject, so as to achieve a better therapeutic effect of tinnitus desensitization.

[0070] The specific process of the method for generating a sound stimulation signal for tinnitus in this embodiment is as follows: Figure 1 shown.

[0071] Step 101, obtaining desensitization test data obtained by the test subject at a test frequency point through a desensitization test; wherein the number of the test frequency point is at least one, and the desensitization test at each test frequency point uses a test sound with a corresponding frequency and a specified playback rhythm.

[0072] Specifically, the central processing module first obtains the desensitization test data obtained by the subject at the test frequency point after the desensitization test, and the desensitization test data includes the result data of the desensitization test of the subject at at least one test frequency point; in an example, please refer to Figure 2 , step 101 specifically includes:

[0073] Sub-step 1011, selecting at least one preset frequency point from the preset frequency points as a test frequency point for the subject.

[0074] The preset frequency may adopt multiple fixed frequencies of commonly used tinnitus tests, specifically, including several frequency points with octave relationships and several common tinnitus frequency points; for example, including: 125Hz, 250Hz, 500Hz, 1000Hz, 2000Hz, 4000Hz, 5000Hz, 6000Hz, 8000Hz, 10000Hz, and 12000Hz, these 12 fixed frequencies.

[0075] Specifically, the method of selecting at least one preset frequency point from the preset frequency points as the test frequency point of the subject may be any one or a combination of the following:

[0076] According to the subject's tinnitus frequency, a preset frequency point that matches the tinnitus frequency is selected as the test frequency point; the subject's tinnitus frequency can be stored in advance in the memory of the tinnitus sound therapy system, and of course it can also be measured in real time, and the measurement method can be a pure tone measurement method; here, a preset frequency point that matches the subject's tinnitus frequency is selected as the test frequency point, for example, a preset frequency point that is the same as the subject's tinnitus frequency or has the smallest difference is selected as the test frequency point.

[0077] Several preset frequency points near the subject's tinnitus frequency are selected as test frequency points. For example, if the tinnitus frequency of subject A is 800 Hz, 800 Hz and several fixed frequencies near 800 Hz (such as 250 Hz, 500 Hz, 1000 Hz and 2000 Hz mentioned above) can be selected as test frequency points.

[0078] At least one preset frequency point is selected from each of the low frequency, the medium frequency, and the high frequency as the test frequency point. For example, the three preset frequency points of 250 Hz, 4000 Hz, and 10000 Hz are selected as the test frequency points.

[0079] Among them, the test frequency points less than the number of preset frequency points can be selected, which can reduce the measurement amount of desensitization data, and still ensure the correlation between the desensitization data and the patient. Among them, the test frequency points are selected based on the tinnitus frequency of the subject, so that the test frequency points that are more suitable for the subject can be selected, so that more accurate estimation results can be obtained later. It should be noted that in some embodiments, all preset frequency points can be selected as test frequency points.

[0080] Sub-step 1012, collecting the minimum masking threshold of tinnitus of the subject at each test frequency point.

[0081] Sub-step 1013, adding a set value to the minimum masking threshold of tinnitus at each test frequency point as the loudness of the test sound at the test frequency point.

[0082] Sub-step 1014, during the desensitization test at each test frequency point, the test sound at the corresponding test frequency point is played at a specified playback rhythm; wherein the specified playback rhythm is within the range of 35-45 Hz.

[0083] Sub-step 1015, collecting the desensitization test data of the subject at each test frequency point, and the desensitization test data of each test frequency point is used to indicate the change of the subject's tinnitus after the corresponding desensitization test.

[0084] Specifically, after the test frequency point is selected, it is necessary to perform a desensitization test on the subject at each test frequency point to obtain the desensitization test data of the subject at each test frequency point; taking a test frequency point K as an example, before the subject performs the desensitization test at the test frequency point K, first obtain the minimum masking threshold (MML) of the tinnitus of the subject at the test frequency point K, and the specific process is, for example: the audio signal generating device can generate a test sound stimulation signal of the corresponding frequency at different frequency points (including the test frequency point K), and based on the test sound stimulation signal, the sound output device is controlled to generate a test sound with a specified playback rhythm corresponding to the test frequency point K; as above, the audio signal generating device outputs the test sound stimulation signal to the sound output device to control the sound output device to output the test sound with a specified playback rhythm at the test frequency point K, and the energy intensity of the narrow-band sound (the test sound of the corresponding frequency) is continuously increased in steps of 2 db, and is played for 1 second at each energy intensity until a confirmation signal input by the subject indicating that the tinnitus can be just covered is received through the data acquisition device, and the current energy intensity is the minimum masking threshold of the subject at the test frequency point K. It should be noted that the specified playback rhythm in this embodiment and the following embodiments is within the range of 35-45 Hz. Preferably, 40 Hz can be selected, and it can also be increased or decreased based on the conditions of different subjects. After obtaining the minimum masking threshold of the tinnitus of the subject at the test frequency point K, the sound output device is controlled to play the test sound of the specified rhythm with the loudness being the minimum masking threshold of the subject at the test frequency point K plus a set value (for example, 10 db above the minimum masking threshold of the tinnitus) for a selectable set duration, for example, 30s, 50s, or 1 minute; and the data acquisition device receives the numerical value representing the percentage of the remaining intensity of the tinnitus (that is, the percentage of the remaining intensity of the tinnitus under the sound stimulation) input by the patient A, and the desensitization time for the tinnitus to recover to the initial intensity input by the subject, the desensitization time being recorded in the following manner, for example: after the test sound stimulation of the 40 Hz rhythm is played at the minimum masking threshold (MML) of the subject at the test frequency point K for a set duration, the timing is started, and the amount of the current remaining tinnitus of the subject is obtained; and when the data acquisition device receives the confirmation signal input by the subject confirming that the tinnitus has recovered to the initial intensity, the timing is stopped, and the timing duration is the desensitization time. The value representing the percentage of the remaining tinnitus intensity input by the subject is the current remaining tinnitus intensity, and the desensitization amplitude can be converted based on the current remaining tinnitus intensity. For example, if the current remaining tinnitus intensity is 30%, the desensitization amplitude is 70%. The data acquisition device can be a mobile phone, a tablet computer, etc., which can display a user interface, and the user can input test data. The user interface is also used to display treatment parameters, treatment effect feedback, etc.

[0085] From the above, the desensitization test data of the subject at the test frequency point K can be obtained, and the desensitization test data indicates the change of the subject's tinnitus after the corresponding desensitization test at each test frequency point; similarly, the desensitization test data of the subject at all test frequency points can be obtained through the desensitization test; the desensitization test data includes: desensitization amplitude and desensitization time; further, the desensitization test data also includes: desensitization score, which is calculated and determined based on the desensitization amplitude and desensitization time. In some examples, the desensitization score of each frequency point is the product of the corresponding desensitization amplitude and desensitization time; for example, the desensitization score of the subject at a certain test frequency point is equal to the product of the desensitization time and the desensitization amplitude of the subject at the test frequency point.

[0086] In some examples, the desensitization score of each frequency point is the result obtained by normalizing or standardizing the product of the corresponding desensitization amplitude and the desensitization time. There are many ways of normalization, and the present application does not limit the specific method of normalization. For example, the specific method is: after obtaining the product of the desensitization amplitude and the desensitization time of the subject at all test frequency points, calculate the average value of the product at all test frequency points (the median can also be selected), and then subtract the difference between the product of the desensitization amplitude and the desensitization time at each test frequency point from the average value as the desensitization score at each test frequency point; alternatively, the difference can be divided by the average value as the final desensitization score.

[0087] Step 102: based on the tinnitus condition of the subject, obtain reference desensitization data matching the subject.

[0088] Specifically, reference desensitization data for different tinnitus conditions can be stored in advance, and then the corresponding reference desensitization data can be obtained by matching according to the tinnitus condition of the subject. The matching conditions can be adopted in a variety of ways, such as using the tinnitus frequency of the subject to characterize the tinnitus condition of the subject, and then the corresponding reference desensitization data can be matched according to the tinnitus frequency of the subject; wherein the tinnitus frequency of the subject can be stored in advance in the memory of the sound treatment system for tinnitus, and of course it can also be measured in real time, and the measurement method is a pure tone measurement method; after the central processing module obtains the tinnitus frequency of the subject, it obtains the reference desensitization data matching the subject according to the tinnitus frequency. For example, the memory of the sound treatment system for tinnitus has preset reference desensitization data corresponding to different tinnitus frequencies, for example, the conventional tinnitus frequency range is divided into several tinnitus frequency segments (for example, low frequency, medium frequency, high frequency), and each tinnitus frequency segment has corresponding reference desensitization data, so that according to the tinnitus frequency segment where the tinnitus frequency of the subject is located, the reference desensitization data corresponding to the tinnitus frequency segment can be used as the reference desensitization data matching the subject. It should be noted that, in this embodiment, the tinnitus frequency of the subject is used as an example to characterize the tinnitus condition of the subject. Other parameters that can characterize the tinnitus condition of the subject can also be applied to the tinnitus sound stimulation signal generation method of this embodiment.

[0089] In some embodiments, a desensitization database is pre-built in the memory of the sound therapy system for tinnitus or in the server of the sound therapy system for tinnitus. The construction process of the desensitization database includes:

[0090] Desensitization test data of patients with different tinnitus frequencies at each preset frequency point are collected; the desensitization test data include desensitization time and desensitization amplitude; the method for determining the desensitization test data of each patient at the preset frequency point is similar to the specific method of conducting desensitization tests on the subjects mentioned above, and will not be repeated here.

[0091] According to the desensitization time and desensitization amplitude of each patient at each preset frequency point, the desensitization score corresponding to each patient at each preset frequency point is calculated; similarly, the patient's desensitization score is calculated and determined based on the desensitization amplitude and desensitization time. In some examples, the desensitization score at each frequency point is the product of the corresponding desensitization amplitude and the desensitization time; for example, the patient's desensitization score at a preset frequency point is equal to the product of the subject's desensitization time and the desensitization amplitude at the preset frequency point.

[0092] In some examples, the desensitization score at each frequency point is the result obtained by normalizing or standardizing the product of the corresponding desensitization amplitude and the desensitization time. The normalization or standardization method is not limited. The specific method of normalization is, for example: after obtaining the product of the patient's desensitization amplitude and the desensitization time at all preset frequency points, calculate the average value of the products at all preset frequency points, and then subtract the difference between the product of the desensitization amplitude and the desensitization time at each preset frequency point from the average value as the desensitization score at each preset frequency point; alternatively, the difference can be divided by the average value as the final desensitization score.

[0093] Therefore, regarding the desensitization score, the product of the desensitization time and the desensitization amplitude can be used. More preferably, the desensitization score is the data obtained by normalizing or standardizing the product of the desensitization time and the desensitization amplitude. Unless otherwise specified, the desensitization score mentioned below is the normalized value of the product of the desensitization time and the desensitization amplitude.

[0094] The collected tinnitus frequency of each patient, the desensitization time and the desensitization amplitude at each preset frequency point are stored; further, the desensitization score at each preset frequency point of each sample patient is stored.

[0095] Based on the above process, the obtained tinnitus frequency of each patient, the desensitization time of each preset frequency point, the desensitization amplitude, and the desensitization score (which may not be stored in the database first, but obtained by calculation in subsequent use) are stored to form a desensitization database.

[0096] That is to say, the desensitization database includes the tinnitus frequencies of multiple patients, the desensitization time of each preset frequency point, the desensitization amplitude, and the desensitization score; the desensitization data of each patient includes the desensitization time and the desensitization amplitude, wherein each patient in the desensitization database has a corresponding tinnitus frequency, there may be one or more patients with different tinnitus frequencies, and the tinnitus frequency of the patient may be measured by the patient through pure tone measurement.

[0097] Furthermore, for each tinnitus frequency patient group (including several patients) in the desensitization database, the frequency-desensitization score curve of the patient group of the tinnitus frequency can be obtained by fitting the data of the desensitization score of the patient group of the tinnitus frequency at each preset frequency point. The curve can also be understood as the corresponding relationship between the frequency point and the desensitization score, so that the desensitization score of the patient group of each tinnitus frequency at different frequency points can be obtained from the curve. Among them, a set frequency range can be preset in advance, and the set frequency range is a conventional tinnitus frequency range, including the above-mentioned preset frequency points, for example, 125Hz to 12000Hz. Thus, for each tinnitus frequency, the desensitization score at different frequency points within the set frequency range can be obtained; wherein, within the set frequency range, the desensitization score at the preset frequency point is the value measured previously, and the desensitization score at the non-preset frequency point is the estimated value obtained by fitting; these data can also be stored in the desensitization database.

[0098] As described above, when obtaining the reference desensitization data matching the subject, the reference desensitization data of the target group matching the subject can be obtained from the pre-constructed desensitization database according to the tinnitus frequency of the subject. The target group matching the subject is a patient group with the same tinnitus frequency as the subject or belonging to the same tinnitus frequency band in the desensitization database. The reference desensitization data of the target group may include the desensitization time, desensitization amplitude and desensitization score of each patient in the target group at each preset frequency point; preferably, the reference desensitization data of the target group is calculated based on the desensitization test data of each patient in the group at each preset frequency point, for example, the reference desensitization data at each preset frequency point is the average value or median value of the desensitization test data of each patient in the target group at the corresponding preset frequency point; taking the desensitization score as an example, the reference desensitization score of the target group at each preset frequency point is the average value or median value of the desensitization score of each patient in the target group at the preset frequency point. It should be noted that the desensitization score of the subject is of the same type as the desensitization score of the patients in the target group, for example, both are the product of the desensitization time and the desensitization amplitude, or both are the product of the desensitization time and the desensitization amplitude after normalization.

[0099] As described above, the testing process for new subjects is simplified, the data of existing patients in the desensitization database are fully utilized, the time for desensitization testing of subjects is reduced, and it is also convenient to improve the efficiency and accuracy of treatment for new subjects in the future.

[0100] Step 103, based on the desensitization test data and reference desensitization data of the subject, determine the energy adjustment parameters of the subject, the energy adjustment parameters at least including: energy adjustment values ​​of the test frequency points.

[0101] The reference desensitization data at least includes reference desensitization data at each test frequency point, thereby combining the desensitization test data of the subject at each test frequency point with the reference desensitization data at each test frequency point to determine the energy adjustment value of the subject at each test frequency point.

[0102] In some embodiments, the reference desensitization data is the reference desensitization data of the target group matching the subject obtained from the desensitization database. Based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point, the energy adjustment parameter of the subject is determined. Please refer to Figure 3 , the step specifically includes:

[0103] Sub-step 1031 , evaluating the desensitization test data of the subject at each preset frequency point according to the desensitization test data of the subject at each test frequency point and the reference desensitization data of the target group at each preset frequency point.

[0104] Specifically, reference desensitization data of the target group at each preset frequency point is obtained from the desensitization database, and the reference desensitization data includes a reference desensitization score; then, for each preset frequency point except the test frequency point, based on the desensitization score of the subject at the preset frequency point and the reference desensitization score of the target group at the preset frequency point, the desensitization score of the subject at each preset frequency point is evaluated. Here, the desensitization score of the subject at each preset frequency point is described as desensitization test data, but it is not limited to this, and a similar method can also be used to evaluate the desensitization amplitude and desensitization time of the subject at each preset frequency point.

[0105] In the above process, the subjects were only tested for desensitization at the test frequency points, and the desensitization scores of the subjects at each test frequency point were obtained. The reference desensitization scores of the target group matching the subjects at each preset frequency point were obtained from the desensitization database. The preset frequency points included the test frequency points, that is, the reference desensitization scores of the target group at each test frequency point were obtained.

[0106] For the preset frequency points for which the subjects have not undergone desensitization testing, the desensitization scores of these preset frequency points can be obtained by estimation, as follows:

[0107] According to the desensitization scores of the subject and the target group at each test frequency point, the target desensitization score of the subject at each test frequency point is obtained; for example, at each test frequency point, the average of the subject's desensitization score and the target group's reference desensitization score is calculated as the target desensitization score.

[0108] In some embodiments, for each test frequency point, the target desensitization score of the subject at each test frequency point is obtained according to the reference desensitization score of the target group at the test frequency point and the first weight of the target group, and the desensitization score of the subject at the test frequency point and the second weight of the subject. That is, a first weight (for example, 0.3) is set for the target group, and a second weight (for example, 0.7) is set for the subject; the sum of the first weight and the second weight is 1. At each test frequency point, the product of the reference desensitization score of the target group and the first weight, and the product of the desensitization score of the subject and the second weight are calculated, and the two products are added together to serve as the target desensitization score of the subject at the test frequency point; wherein, if there are multiple patients in the target group, the average value of the desensitization scores of all patients in the target group at the test frequency point, the product of the average value and the first weight, and the product of the desensitization score of the subject and the second weight are added together to serve as the reference desensitization score of the subject at the test frequency point.

[0109] Subsequently, based on the target desensitization score of the subject at each test frequency point, the desensitization score of the subject at each preset frequency point other than the test frequency point among multiple preset frequency points is obtained by interpolation; the interpolation method used may be Lagrange interpolation, cubic spline interpolation, etc., but is not limited thereto, and commonly used interpolation methods may be used here.

[0110] Thus, the desensitization scores of the subjects at all preset frequency points can be obtained.

[0111] In some embodiments, after obtaining the desensitization scores of the subject at all preset frequency points, the desensitization scores at the preset frequency points other than the test frequency points may be corrected. The specific correction method is:

[0112] First, the desensitization score deviation of the subject and the target group at each test frequency point is obtained, and the desensitization score deviation is the difference between the desensitization score of the subject and the reference desensitization score of the target group;

[0113] Then, for each preset frequency point except the test frequency point, the desensitization score of the evaluated subject at each preset frequency point is adjusted based on the desensitization score deviation between the subject and the target group at each test frequency point. For example, the average deviation value of the desensitization score deviation between the subject and the target group at each test frequency point can be calculated, and then for the desensitization score of the evaluated subject at each preset frequency point (non-test frequency point), the sum of the desensitization score of each preset frequency point (non-test frequency point) and the average deviation value is calculated to obtain the final desensitization score of each preset frequency point (non-test frequency point). For another example, for the desensitization score of the evaluated subject at each preset frequency point (non-test frequency point), the test frequency point closest to the preset frequency point is selected, and then the desensitization score deviation at the test frequency point is obtained, and the desensitization score of the preset frequency point and the desensitization score deviation at the test frequency point are calculated as the final desensitization score of the preset frequency point.

[0114] Sub-step 1032, based on the desensitization test data of the subject at each preset frequency point, obtain the desensitization test data of the subject at each frequency point within a set frequency range, and the set frequency range includes all the preset frequency points.

[0115] Specifically, the desensitization score of the subject at each frequency within the set frequency range is determined based on the desensitization score of the subject at all preset frequency points. For example, the frequency-desensitization score curve of the subject is obtained by fitting based on the data of the desensitization score of the subject at each preset frequency point, and thus the desensitization score of the subject at each frequency point within the set frequency range can be obtained from the curve. Among them, within the set frequency range, the desensitization score of the subject at the test frequency point is the value measured previously, the desensitization score at the preset frequency point other than the test frequency point is the desensitization score obtained by the interpolation method mentioned above, and the desensitization score at the non-preset frequency point is the estimated value obtained by fitting.

[0116] In addition, when fitting the frequency-desensitization score curve of the subject based on the data of the desensitization score of the subject at each preset frequency point, the desensitization score of the subject at each preset frequency point used may all be the target desensitization score of the subject at each preset frequency point; however, it is not limited to this, and the measured desensitization score of the subject may be used at the test frequency point, and the target desensitization score of the subject may be used at the preset frequency point that is not a preset frequency point.

[0117] It should be noted that if the test frequency point includes all the preset frequency points, then for each preset frequency point, the target desensitization score of the subject at the preset frequency point is obtained directly based on the desensitization score of the target group at the preset frequency point and the first weight of the target group, as well as the desensitization score of the subject at the preset frequency point and the second weight of the subject; then the frequency-desensitization score curve of the subject is obtained by fitting using the target desensitization score of the subject at each preset frequency point, and the desensitization score of the subject at each frequency point within the set frequency range can also be obtained from the curve.

[0118] Sub-step 1033, compares the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database, and obtains the energy adjustment parameters of the subject, the energy adjustment parameters including: the energy adjustment value of each frequency point within the set frequency range.

[0119] Specifically, the average desensitization score of the target group at each preset frequency point is obtained based on the desensitization database, and then the baseline desensitization score of the target group at each frequency point within the set frequency range is obtained based on the average desensitization score of the target group at each preset frequency point; the target group may include one or more patients, and after obtaining the desensitization scores of multiple patients in the target group at each preset frequency point, the mean or median of the desensitization scores of these patients at each preset frequency point is calculated respectively, and the average desensitization score of the target group at each preset frequency point can be obtained, and then the frequency-desensitization score curve of the target group can be fitted based on the average desensitization score of the target group at each preset frequency point, which characterizes the desensitization scores of the target group at each frequency point within the set frequency range, that is, the baseline desensitization score at each frequency point.

[0120] Based on the desensitization scores of the subjects at each preset frequency point, the desensitization scores of the subjects at each frequency point within the set frequency range are obtained; for example, based on the data of the desensitization scores of the subjects at each preset frequency point, the frequency-desensitization score curve of the subjects is obtained by fitting, and thus the desensitization scores of the subjects at each frequency point within the set frequency range can be obtained from the curve.

[0121] In another embodiment, after obtaining the desensitization test data of the subject at each test frequency point, the desensitization test data includes a desensitization score; fitting can be performed based on the desensitization score of the subject at each test frequency point and the reference desensitization score data of the target group in the database at each preset frequency point, and the weights can be reset at the same time. The weight setting can be set according to actual conditions, and the present application does not limit the specific value of the weight setting. For example, the weight of the subject's desensitization score data is 30%, and the weight of the reference desensitization score of the target group in the remaining database is 70%. After fitting, the frequency-desensitization score curve of the subject is obtained. Figure 4 As shown, the x-axis is frequency, the y-axis is desensitization score, the discrete data points represent the desensitization test scores of the subjects at the corresponding test frequency points (as mentioned before, the desensitization scores in the figure are the desensitization scores after normalization or standardization), and the curve is the fitted frequency-desensitization score curve of the subjects; the k in 4k, 5k, 6k, 8k, 10k and 12k represents 1000.

[0122] Specifically, for untested preset frequency points, the desensitization scores of the subjects at each preset frequency point other than the test frequency point can be evaluated by frequency interpolation based on the desensitization scores of the subjects at each test frequency point and the reference desensitization scores of the target group at each preset frequency point; and then the desensitization scores of the subjects at each preset frequency point within the set frequency range can be obtained based on the desensitization scores of the subjects at each preset frequency point and the reference desensitization scores of the target group at the preset frequency point, combined with the first scoring weight of the subjects and the second scoring weight of the target group. For example, for each preset frequency point, the reference desensitization scores of the subjects at each preset frequency point are obtained according to the desensitization scores of the target group at the preset frequency point and the first scoring weight of the target group, and the desensitization scores of the subjects at the preset frequency point and the second scoring weight of the subjects. That is, a first scoring weight (for example, 0.65) is set for the target group, and a second scoring weight (for example, 0.35) is set for the subject; the sum of the first scoring weight and the second scoring weight is 1. At each preset frequency point, the product of the reference desensitization score of the target group and the first scoring weight, and the product of the desensitization score of the subject and the second scoring weight are calculated, and the two products are added together to serve as the reference desensitization score of the subject at the preset frequency point. Then, the frequency-desensitization score curve of the subject can be obtained by fitting based on the reference desensitization score of the subject at the preset frequency point, and thus the desensitization score of the subject at each frequency point within the set frequency range can be obtained from the curve.

[0123] Based on the desensitization scores of the subjects at each frequency point within the set frequency range and the baseline desensitization scores of the target group at each frequency point within the set frequency range, the difference between the desensitization scores of the subjects at each frequency point within the set frequency range and the average desensitization score of the target group is compared.

[0124] determining the energy regulation parameter of the subject according to the difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group;

[0125] Specifically, for each frequency point within the set frequency range, the difference between the desensitization score of the subject at the frequency point and the benchmark desensitization score of the target group at the frequency point is calculated to obtain the score difference at the frequency point, thereby obtaining the score difference at each frequency point within the set frequency range; and then the energy regulation parameter of the subject is determined according to the difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group. Among them, the frequency points corresponding to the score difference greater than the first difference threshold or less than the second difference threshold can be deleted and replaced with the score difference of the adjacent frequency points (need to be between the first difference threshold and the second difference threshold).

[0126] For each frequency point, if the score difference of the frequency point is greater than the first set value, the sound energy value of the frequency point is increased, and the energy adjustment value of the frequency point is an energy increase value (positive value). The size of the energy increase value for increasing the energy at the frequency point is determined based on the score difference. For example, the correspondence between the score difference and the energy increase value is preset in advance, and based on the correspondence, the energy increase value corresponding to the difference can be determined; the larger the difference, the larger the corresponding energy increase value; for another example, multiple first difference intervals are preset in advance, and each first difference interval has a corresponding energy increase value. The energy increase value can be a fixed energy value such as 2db, or it can be a percentage value, such as 20%; thereby, based on the first difference interval to which the score difference belongs, the corresponding energy increase value can be determined; wherein, the first set value is greater than or equal to 0, and the first set value can be a positive value close to 0.

[0127] If the score difference of the frequency point is lower than the second set value, the energy value of the sound at the frequency point is reduced, and the energy adjustment value of the frequency point is an energy reduction value (negative value). For example, the corresponding relationship between the score difference and the energy reduction value is preset in advance. Based on the corresponding relationship, the energy reduction value corresponding to the score difference can be determined; the smaller the score difference, the larger the corresponding energy reduction value; for example, multiple second difference intervals are preset in advance, and each interval has a corresponding energy reduction value. The energy reduction value can be a fixed energy value such as 2db, or a percentage value such as 20%; thus, the corresponding energy reduction value can be determined based on the second difference interval to which the score difference belongs. Among them, the second set value is less than or equal to 0, and the second set value can be a negative value close to 0.

[0128] Specifically, Figure 5As shown in the figure, the x-axis is frequency, the y-axis is desensitization score, and the discrete data points are the desensitization scores of another subject at the corresponding test frequency points; the blue curve in the figure is the fitted frequency-desensitization score curve of the subject, and the orange straight line is the average desensitization score reference line of the target group; if the first setting value and the second setting value are both 0, then in the frequency-desensitization score curve of the subject, the frequency segment above the average desensitization score reference line corresponds to increasing the energy value of the sound (such as increasing by 1-5dB), and for the frequency segment below the average desensitization score reference line, it corresponds to reducing the energy value of the sound (such as reducing by 1-5dB), so that the energy adjustment parameters of the subject in each frequency segment can be obtained; the k in 4k, 5k, 6k, 8k, 10k and 12k represents 1000.

[0129] From the above, the energy regulation parameters of each frequency of the subject within the set frequency range can be determined. The energy regulation parameters of the subject include: the energy regulation value of each frequency, and the energy regulation value can be an energy increase value or an energy decrease value; based on this, a frequency-energy regulation value (energy increase value or energy decrease value) curve can be fitted, which can be called the subject's frequency domain energy modulation curve, and the energy regulation value corresponding to each frequency point can be obtained from the curve.

[0130] Step 104, adjusting the sound energy of the preset sound stimulation signal according to the energy adjustment parameter of the subject to obtain a target sound stimulation signal matching the subject.

[0131] Step 103 includes: converting the preset sound stimulation signal into a sound frequency domain signal, adjusting the energy of the sound frequency domain signal at each frequency point within the set frequency range using the energy adjustment value of the subject at each frequency point; converting the energy-adjusted sound frequency domain signal to obtain a target sound stimulation signal.

[0132] Specifically, the storage module of the sound therapy system for tinnitus stores a preset sound stimulation signal, which may be white noise, music, etc., or an audio signal introduced by the subject; preferably, the preset sound stimulation signal is a wide-band signal, and its frequency range at least includes the set frequency range, or may only include the set frequency range.

[0133] The preset sound stimulation signal is a time domain signal, the horizontal axis is time, and the vertical axis is energy value; the preset sound stimulation signal is first Fourier transformed to convert it from time domain to frequency domain to obtain a sound frequency domain signal, the horizontal axis of the sound frequency domain signal is frequency, and the vertical axis is energy value; then the energy adjustment parameter of the subject, that is, the frequency domain energy modulation curve of the subject is used to adjust the energy value of each frequency point in the sound frequency domain signal. Taking a frequency point P2 as an example, assuming that the energy adjustment value of the frequency point P2 in the energy adjustment parameter is the energy increase value, the energy increase value is 20%, and the energy value of the frequency point P2 in the sound frequency domain signal is 20db, then it is increased by 20%, and the energy value of the frequency point P2 after adjustment is 20×1.2=24db; thereby, the energy value of each frequency point in the sound frequency domain signal is adjusted accordingly to obtain a sound frequency domain signal after energy adjustment, and then the sound frequency domain signal is inverse Fourier transformed to convert it from frequency domain to time domain to obtain a target sound stimulation signal.

[0134] During the above energy modulation process, the energy or amplitude of the preset sound stimulation signal at each frequency is modulated. For the frequency points where the subject has a good desensitization effect, the energy value of the target sound stimulation signal at these frequency points is increased, so that the energy value of these frequency points and the change amplitude between the adjacent frequency points are larger; for the frequency points where the subject has a poor desensitization effect, the energy value of these frequency points is reduced, so that the energy change amplitude between the energy value of these frequency points and the adjacent frequency points is reduced. Through this differentiated setting of energy modulation, a stronger rhythmic stimulation can be applied in the frequency range where the subject is sensitive, while the rhythmic stimulation can be weakened in the frequency range where the subject is not sensitive, thereby increasing the energy change amplitude and further improving the therapeutic effect of tinnitus desensitization.

[0135] Furthermore, after step 104, the method further includes:

[0136] Step 105, modulate the target sound stimulation signal according to the specified playback rhythm to serve as the final output target sound stimulation signal; the specified playback rhythm is within the range of 35-45 Hz.

[0137] Specifically, taking the specified playback rhythm as being within the range of 35-45Hz, and taking the specified playback rhythm as 40Hz as an example, the modulation period of the 40Hz rhythm modulation is the time length of a complete "play-stop" cycle, for example, setting it to 25ms, then the target sound stimulation signal is controlled to be played according to the rhythm of playing for 12.5ms and stopping for 12.5 milliseconds; the specific method is, for example: superimposing a 40Hz modulation signal (such as a square wave signal) on the target sound stimulation signal, the period of which is 25ms, wherein the high level lasts for 12.5ms and the low level lasts for 12.5ms, that is, the target sound stimulation signal is periodically modulated, the modulation frequency = 1 / 25ms = 40Hz, that is, 40Hz rhythm modulation is achieved, the target sound stimulation signal is played in the high level segment of the modulation signal (square wave signal), and the low level segment is muted by the target sound stimulation signal.

[0138] That is to say, the central processing module controls the sound output device to play the target sound stimulation signal at a 40 Hz rhythm. Therefore, playing the target sound stimulation signal at a 40 Hz rhythm can effectively regulate the function of brain nerve activity and produce a better tinnitus desensitization effect on the subject.

[0139] In this embodiment, when the sound treatment system for tinnitus treats the current user, the central processing module can control the sound output device to output the target sound stimulation signal at a 40Hz rhythm, and reacquire the subject's tinnitus frequency after each treatment, the treatment time reaches a certain length of time, or each treatment cycle, and re-measure the subject's desensitization score at each preset frequency point, and then repeat the above steps 101 to 104 to optimize and update the obtained target sound stimulation signal, so as to achieve a better treatment effect in the subsequent tinnitus desensitization treatment. Through multiple optimizations, the best desensitization effect can be achieved. Furthermore, the parameters can be further optimized according to the tinnitus THI scale, tinnitus visual analog scale, and tinnitus loudness feedback from the subject. Specifically, if the subject feedbacks that the tinnitus treatment effect is good, the desensitization test data of the subject can be included in the database, so that the energy adjustment parameters obtained based on the desensitization database and the desensitization test data of the new patient are more accurate, which is more conducive to the tinnitus treatment of the new patient.

[0140] A second embodiment of the present invention relates to a desensitization test system for performing a desensitization test on a subject. The desensitization test system comprises:

[0141] A masking test module is used to obtain a minimum masking threshold of a subject at a test frequency point; the number of the test frequency point is at least one;

[0142] A test sound generation module is used to generate a test sound used by the subject in the desensitization test at each test frequency point; the desensitization test at each test frequency point uses a test sound of a corresponding frequency, a loudness above the minimum masking threshold of the subject at the test frequency point, and a specified playback rhythm;

[0143] A sound output device, used for playing the test sound of the desensitization test;

[0144] The data acquisition module is used to collect the desensitization test data of the subject at each test frequency point; the desensitization test data of each test frequency point is used to indicate the change of the subject's tinnitus after the corresponding desensitization test.

[0145] The specific process of performing the desensitization test on the subject can be found in the relevant content of the first embodiment, which will not be repeated here.

[0146] A third embodiment of the present invention relates to a device for generating a sound stimulation signal for tinnitus, comprising:

[0147] The first acquisition module is used to obtain the desensitization test data obtained by the subject through the desensitization test at the test frequency point;

[0148] The second acquisition module is used to obtain the tinnitus condition of the subject, such as tinnitus frequency and / or tinnitus sound type;

[0149] The data processing module is respectively connected to the first acquisition module and the second acquisition module in communication; the data processing module is configured to execute the method for generating a sound stimulation signal for tinnitus according to the first embodiment of the claim.

[0150] Since the first embodiment corresponds to this embodiment, this embodiment can be implemented in conjunction with the first embodiment. The relevant technical details mentioned in the first embodiment are still valid in this embodiment, and the technical effects that can be achieved in the first embodiment can also be achieved in this embodiment. In order to reduce repetition, they are not repeated here. Accordingly, the relevant technical details mentioned in this embodiment can also be applied in the first embodiment.

[0151] A fourth embodiment of the present invention relates to a sound therapy system for tinnitus, comprising: a central processing module and a sound output device. The central processing module may be a conventional processor, a microcontroller, etc., and the sound output device may be a wearable headset or a speaker. The central processing module and the sound output device may be wired or wirelessly communicated.

[0152] The central processing module can execute the sound stimulation signal generation method of the first embodiment to generate a target sound stimulation signal that is adapted to the tinnitus condition of the subject, and control the sound output device to output a corresponding stimulation sound based on the target sound stimulation signal; further, before controlling the sound output device to output the corresponding stimulation sound, the target sound stimulation signal can be modulated to a specified playback rhythm, and the specified playback rhythm is within the range of 35-45 Hz, for example, a 40 Hz rhythm, because 40 Hz sound stimulation can regulate brain nerve activity and can play a role in alleviating tinnitus, and the target sound stimulation signal is related to the tinnitus desensitization parameter of the subject, so that the sound stimulation of the 40 Hz rhythm finally output can be adapted to the individual condition of the subject, so as to achieve a better therapeutic effect of tinnitus desensitization.

[0153] In some embodiments, the sound treatment system for tinnitus further includes: an audio signal generating device and a data acquisition device; wherein:

[0154] An audio signal generating device is used to generate a test sound for the subject during the desensitization test at each test frequency point; the desensitization test at each test frequency point uses a test sound of a corresponding frequency, a loudness above the minimum masking threshold of the subject at the test frequency point, and a specified playing rhythm;

[0155] The sound output device is also used to play the test sound generated by the audio signal generating device;

[0156] A data acquisition device, used to collect desensitization test data of the subject at each test frequency point; the desensitization test data at each test frequency point is used to indicate the change of tinnitus of the subject after the corresponding desensitization test;

[0157] The data acquisition device is also used to collect the tinnitus condition of the subject; and transmit the desensitization test data of the subject at each test frequency point and the tinnitus condition of the subject to the central processing module.

[0158] Specifically, the audio signal generating device can generate the sound stimulation signals required for the desensitization test at multiple frequencies; the central processing module is used to execute the relevant steps of the desensitization test, including controlling the sound output device through the audio signal generating device to play the test sound corresponding to the test frequency point according to the specified playback rhythm.

[0159] The central processing module is also used to receive the desensitization test data of the subject at each test frequency and the tinnitus condition of the subject (such as tinnitus frequency) through the data acquisition device.

[0160] The audio signal generating device, the sound output device and the data acquisition device constitute a data collection system, which can be used to collect the desensitization data and tinnitus conditions of different patients to form a desensitization database. On the other hand, after the desensitization database is established, the desensitization data and tinnitus conditions of the subject can also be collected to provide a customized basis for the generation of the sound stimulation signal required for the tinnitus sound treatment of the subject. The central processing module, the sound output device and the data acquisition device form a stimulation sound synthesis system, which can generate a target sound stimulation signal suitable for the subject.

[0161] Since the first embodiment corresponds to this embodiment, this embodiment can be implemented in conjunction with the first embodiment. The relevant technical details mentioned in the first embodiment are still valid in this embodiment, and the technical effects that can be achieved in the first embodiment can also be achieved in this embodiment. In order to reduce repetition, they are not repeated here. Accordingly, the relevant technical details mentioned in this embodiment can also be applied in the first embodiment.

[0162] The fifth embodiment of the present invention relates to a computer-readable storage medium, which is a non-volatile storage medium or a non-transient storage medium, on which a computer program is stored. When the computer program is executed by a processor, the steps of the method for generating a sound stimulation signal for tinnitus in the first embodiment are executed.

[0163] Preferred embodiments of the present invention have been described above in detail, but it should be understood that aspects of the embodiments can be modified, if necessary, to employ aspects, features and concepts of the various patents, applications and publications to provide further embodiments.

[0164] These and other changes can be made to the embodiments in light of the above detailed description.In general, in the claims, the terms used should not be considered limited to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which these claims are entitled.

Claims

1. A method for generating a sound stimulation signal for tinnitus, characterized in that: include: Obtaining desensitization test data obtained by the subject through a desensitization test at a test frequency point; wherein the number of the test frequency point is at least one, and the desensitization test at each test frequency point uses a test sound with a corresponding frequency and a specified playback rhythm; Based on the tinnitus condition of the subject, obtaining reference desensitization data matching the subject; Determining the energy adjustment parameters of the subject based on the desensitization test data of the subject and the reference desensitization data, wherein the energy adjustment parameters at least include: the energy adjustment value of the test frequency point; The sound energy of a preset sound stimulation signal is adjusted according to the energy adjustment parameter of the subject to obtain a target sound stimulation signal matching the subject.

2. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: The method of obtaining the desensitization test data obtained by the subject through the desensitization test at the test frequency point includes: Selecting at least one preset frequency point from each preset frequency point as a test frequency point of the subject; Collecting the minimum masking threshold of tinnitus of the subject at each of the test frequency points; Adding a set value to the minimum masking threshold of tinnitus at each test frequency point as the loudness of the test sound at the test frequency point; During the desensitization test at each test frequency point, the test sound corresponding to the test frequency point is played according to the specified playback rhythm; wherein the specified playback rhythm is within the range of 35-45 Hz; The desensitization test data of the subject at each of the test frequency points is collected, and the desensitization test data of each of the test frequency points is used to indicate the change of tinnitus of the subject after the corresponding desensitization test.

3. The method for generating a sound stimulation signal for tinnitus according to claim 1 or 2, characterized in that: The test sound used by the subject during the desensitization test has any one or more of the following characteristics: The test sound is a narrowband sound or a pure tone at a frequency corresponding to the current test frequency point; The loudness of the test sound is 5-15 dB above the minimum masking threshold of tinnitus of the subject at the corresponding test frequency point; The specified playing rhythm of the test sound is 40 Hz.

4. The method for generating a sound stimulation signal for tinnitus according to claim 1 or 2, characterized in that: The desensitization test data includes desensitization amplitude and desensitization time.

5. The method for generating a sound stimulation signal for tinnitus according to claim 4, characterized in that: The desensitization test data also includes a desensitization score; the desensitization score is calculated and determined based on the desensitization amplitude and the desensitization time.

6. The method for generating a sound stimulation signal for tinnitus according to claim 2, characterized in that: The selecting at least one preset frequency point from the preset frequency points as the test frequency point of the subject includes any one or more of the following: According to the tinnitus frequency of the subject, selecting a preset frequency point matching the tinnitus frequency as a test frequency point; Selecting several preset frequency points near the subject's tinnitus frequency as test frequency points; At least one preset frequency point is selected from each of the low frequency, the medium frequency and the high frequency as a test frequency point.

7. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: The step of obtaining reference desensitization data matching the subject based on the tinnitus condition of the subject includes: According to the tinnitus frequency of the subject, obtaining reference desensitization data of a target group matching the subject from a pre-constructed desensitization database; The step of determining the energy regulation parameters of the subject based on the desensitization test data of the subject and the reference desensitization data includes: The energy regulation parameters of the subject are determined based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point.

8. The method for generating a sound stimulation signal for tinnitus according to claim 7, characterized in that: The step of determining the energy regulation parameters of the subject based on the desensitization test data of the subject and the reference desensitization data of the target group at each preset frequency point includes: Evaluating the desensitization test data of the subject at each of the preset frequency points according to the desensitization test data of the subject at each of the test frequency points and the reference desensitization data of the target group at each of the preset frequency points; According to the desensitization test data of the subject at each of the preset frequency points, obtaining the desensitization test data of the subject at each frequency point within a set frequency range, wherein the set frequency range includes all of the preset frequency points; The desensitization test data of the subject at each frequency point within the set frequency range is compared with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database to obtain the energy regulation parameters of the subject, wherein the energy regulation parameters include: energy regulation values ​​at each frequency point within the set frequency range.

9. The method for generating a sound stimulation signal for tinnitus according to claim 8, characterized in that: The step of evaluating the desensitization test data of the subject at each of the preset frequency points according to the desensitization test data of the subject at each of the test frequency points and the reference desensitization data of the target group at each of the preset frequency points comprises: Acquire reference desensitization data of the target group at each of the preset frequency points from the desensitization database, wherein the reference desensitization data includes a reference desensitization score; For each of the preset frequency points except the test frequency point, based on the desensitization score of the subject at the test frequency point and the reference desensitization score of the target group at the preset frequency point, the desensitization score of the subject at each of the preset frequency points is evaluated.

10. The method for generating a sound stimulation signal for tinnitus according to claim 9, characterized in that: After obtaining the reference desensitization data of the target group at each of the preset frequency points from the desensitization database, the method further includes: Obtaining a desensitization score deviation between the subject and the target group at each test frequency point, the desensitization score deviation being a difference between the desensitization score of the subject and a reference desensitization score of the target group; After evaluating the desensitization score of the subject at each of the preset frequency points except the test frequency point based on the desensitization score of the subject at the preset frequency point and the reference desensitization score of the target group at the preset frequency point, the method further includes: For each of the preset frequency points except the test frequency point, the desensitization score of the assessed subject at each of the preset frequency points is adjusted based on the deviation of the desensitization score between the subject and the target group at each of the test frequency points.

11. The method for generating a sound stimulation signal for tinnitus according to claim 8, characterized in that: The comparing the desensitization test data of the subject at each frequency point within the set frequency range with the reference desensitization data of the target group at each frequency point within the set frequency range obtained based on the desensitization database to obtain the energy regulation parameter of the subject includes: Obtaining an average desensitization score of the target group at each of the preset frequency points based on the desensitization database; Based on the average desensitization score of the target group at each of the preset frequency points, obtaining a baseline desensitization score of the target group at each frequency point within a set frequency range; Based on the desensitization score of the subject at each of the preset frequency points, obtaining the desensitization score of the subject at each frequency point within the set frequency range; Based on the desensitization score of the subject at each frequency point within the set frequency range and the baseline desensitization score of the target group at each frequency point within the set frequency range, a score difference between the desensitization score of the subject at each frequency point within the set frequency range and the baseline desensitization score of the target group is obtained by comparison; The energy regulation parameter of the subject is determined according to the score difference between the desensitization score of the subject at each frequency point and the average desensitization score of the target group; wherein, if the score difference is greater than a first set value, the sound energy value of the corresponding frequency point is increased; if the score difference is lower than a second set value, the energy value of the sound at the corresponding frequency point is reduced; wherein, the first set value is greater than or equal to 0, and the second set value is less than or equal to 0.

12. The method for generating a sound stimulation signal for tinnitus according to claim 11, characterized in that: The step of obtaining the desensitization score of the subject at each frequency point within the set frequency range based on the desensitization score of the subject at each preset frequency point comprises: Based on the desensitization score of the subject at each of the preset frequency points and the reference desensitization score of the target group at the preset frequency point, combined with the first score weight of the subject and the second score weight of the target group, the desensitization score of the subject at each frequency point within the set frequency range is obtained.

13. The method for generating a sound stimulation signal for tinnitus according to claim 7, characterized in that: The construction process of the desensitization database includes: Collect desensitization test data of patients with different tinnitus frequencies at each preset frequency point; the desensitization test data includes desensitization time and desensitization amplitude; According to the desensitization time and desensitization amplitude of each patient at each preset frequency point, the desensitization score corresponding to each patient at each preset frequency point is calculated; The collected tinnitus frequency, desensitization time, desensitization amplitude, and desensitization score of each patient are stored.

14. The method for generating a sound stimulation signal for tinnitus according to any one of claims 5, 9, 10, 11, 12, and 13, characterized in that: The desensitization score of each frequency point is the product of the corresponding desensitization amplitude and the desensitization time; or the desensitization score of each frequency point is the result obtained by normalizing or standardizing the product of the corresponding desensitization amplitude and the desensitization time.

15. The method for generating a sound stimulation signal for tinnitus according to claim 1, characterized in that: After obtaining the target stimulus sound, the method further includes: The target sound stimulation signal is modulated according to the specified playback rhythm to serve as the final output target sound stimulation signal; the specified playback rhythm is within the range of 35-45 Hz.

16. A desensitization test system, characterized in that: include: The masking test module is used to obtain the minimum masking threshold of the subject at the test frequency point; The number of the test frequency points is at least one; A test sound generation module is used to generate a test sound used by the subject in the desensitization test at each test frequency point; the desensitization test at each test frequency point uses a test sound of a corresponding frequency, a loudness above the minimum masking threshold of the subject at the test frequency point, and a specified playback rhythm; A sound output device, used for playing the test sound of the desensitization test; The data acquisition module is used to collect the desensitization test data of the subject at each test frequency point; the desensitization test data at each test frequency point is used to indicate the change of tinnitus of the subject after the corresponding desensitization test.

17. A device for generating a sound stimulation signal for tinnitus, characterized in that: include: The first acquisition module is used to obtain the desensitization test data obtained by the subject through the desensitization test at the test frequency point; A second acquisition module is used to obtain the tinnitus condition of the subject; A data processing module is respectively connected to the first acquisition module and the second acquisition module in communication; the data processing module is configured to execute the method for generating a sound stimulation signal for tinnitus according to any one of claims 1 to 15.

18. A sound treatment system for tinnitus, characterized in that: include: Central processing module and sound output device; The central processing module is used to execute the method for generating a sound stimulation signal for tinnitus according to any one of claims 1 to 15, to obtain a target sound stimulation signal for output to a subject; The central processing module is also used to control the sound output device to play corresponding sounds based on the target sound stimulation signal.

19. The sound treatment system for tinnitus according to claim 18, characterized in that: The acoustic treatment system for tinnitus also includes: an audio signal generating device and a data acquisition device; wherein: The audio signal generating device is used to generate a test sound for the subject during the desensitization test at each test frequency point; the desensitization test at each test frequency point uses a test sound of a corresponding frequency, a loudness above the minimum masking threshold of the subject at the test frequency point, and a specified playing rhythm; The sound output device is also used to play the test sound generated by the audio signal generating device; The data acquisition device is used to collect the desensitization test data of the subject at each test frequency point; the desensitization test data at each test frequency point is used to indicate the change of the tinnitus of the subject after the corresponding desensitization test; The data acquisition device is also used to collect the tinnitus condition of the subject; and transmit the desensitization test data of the subject at each test frequency point and the tinnitus condition of the subject to the central processing module.

20. A computer-readable storage medium, wherein the computer-readable storage medium is a non-volatile storage medium or a non-transient storage medium, and a computer program is stored thereon, wherein: When the computer program is executed by a processor, the steps of the method for generating a sound stimulation signal for tinnitus according to any one of claims 1 to 15 are executed.

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