Lipid-lowering and pulse-invigorating composition and preparation method thereof

Abstract

The invention provides a lipid-lowering and blood-circulation-promoting composition and a preparation method thereof, and relates to the field of traditional Chinese medicinal materials, the lipid-lowering and blood-circulation-promoting composition is prepared from the following raw materials in parts by weight: 1-3 parts of pseudo-ginseng, 2-5 parts of radix salviae miltiorrhizae, 3-6 parts of fried semen cassiae, 4-6 parts of hawthorn, 3-6 parts of fried rhizoma atractylodis macrocephalae, 1-3 parts of polygonum multiflorum and 1-3 parts of lumbricus, all the raw materials are dried, crushed and then prepared into pills, and the lipid-lowering and blood-circulation-promoting composition is obtained. The traditional Chinese medicine composition has the effects of reducing blood fat, resisting thrombus, reducing cholesterol and treating atherosclerosis and fatty liver.

Description

Technical Field

[0001] The present invention relates to the field of Chinese medicinal materials, and in particular to a lipid-lowering and blood vessel-opening composition and a composition thereof. Background Art

[0002] Hyperlipidemia is a common disease. Its incidence rate increases significantly with age, and it is especially common in obese people. Hyperlipidemia is also one of the causes of arteriosclerosis and coronary heart disease.

[0003] In the field of Western medicine, the drugs for treating hyperlipidemia mainly include: Statins: such as lovastatin, simvastatin, atorvastatin, etc., which mainly lower blood lipids by inhibiting the synthesis of cholesterol. Fibrates: such as bezafibrate, fenofibrate, etc., are mainly used to lower triglycerides, suitable for hypertriglyceridemia and mixed hyperlipidemia. Nicotinic acid drugs: such as inositol nicotinate, niacin, etc., can lower cholesterol and triglycerides in plasma and improve blood lipid profile. Cholesterol absorption inhibitors: such as ezetimibe, which lower blood lipids by inhibiting the absorption of blood lipids in the intestine.

[0004] In the field of traditional Chinese medicine, Chinese medicine preparations for the treatment of hyperlipidemia include: Xuezhiping tablets, Hedan tablets, Zhibituo capsules, etc., which also have a certain lipid-lowering effect. The lipid-lowering mechanism of Chinese medicine preparations is as follows: 1. Promote intestinal lipid excretion: drugs such as Artemisia capillaris, Rhubarb, and Polygonum multiflorum accelerate the excretion of lipids by promoting bile secretion and intestinal peristalsis. 2. Inhibit intestinal lipid absorption: For example, pollen, mung bean, brown algae, etc. contain plant sterols or polysaccharide components, which can combine with bile salts to form complexes and hinder the absorption of cholesterol in the intestine. 3. Inhibit lipid synthesis: drugs such as Alisma orientalis and turmeric can affect lipid decomposition and cholesterol synthesis, and reduce the production of cholesterol in the body. 4. Affect blood lipid distribution, transport and clearance: drugs such as Salvia miltiorrhiza and silymarin can promote the oxidative decomposition of fat in the liver, eliminate liver and kidney tissue deposition, and accelerate the transport and clearance of blood lipids.

[0005] Western medicine preparations are effective quickly, but they have different degrees of toxic side effects, which are difficult for some patients to accept. Traditional Chinese medicine preparations have fewer side effects, but they are slow to take effect. In addition, existing traditional Chinese medicine preparations have the disadvantages of poor therapeutic effect, slow effect, and single function in the treatment of hyperlipidemia. Summary of the invention

[0006] The purpose of the present invention is to provide a lipid-lowering and blood vessel-opening composition, which has the effects of lowering blood lipids, resisting thrombosis, lowering cholesterol, and having a good therapeutic effect on atherosclerosis and fatty liver.

[0007] Another object of the present invention is to provide a method for preparing a lipid-reducing and blood vessel-opening composition, which is simple and efficient and can fully utilize the effective ingredients of each raw material.

[0008] The present invention solves the technical problem by adopting the following technical solutions.

[0009] In one aspect, an embodiment of the present invention provides a lipid-lowering and blood vessel-opening composition, comprising the following raw materials in parts by weight:

[0010] 1-3 parts of Panax notoginseng, 2-5 parts of Salvia miltiorrhiza, 3-6 parts of stir-fried Cassia seeds, 4-6 parts of Hawthorn, 3-6 parts of stir-fried Atractylodes macrocephala, 1-3 parts of Polygonum multiflorum, and 1-3 parts of Pheretima.

[0011] In some embodiments of the present invention, the following raw materials are included by weight: 3 parts of Panax notoginseng, 5 parts of Salvia miltiorrhiza, 6 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

[0012] In some embodiments of the present invention, the following raw materials are included by weight: 3 parts of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 3 parts of Polygonum multiflorum, and 3 parts of Pheretima.

[0013] In some embodiments of the present invention, the following raw materials are included by weight: 1 part of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 6 parts of hawthorn, 6 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

[0014] On the other hand, an embodiment of the present invention provides a method for preparing a lipid-lowering and blood-clearing composition, comprising the following steps: sterilizing each raw material at high temperature, drying, and then crushing Panax notoginseng and Salvia miltiorrhiza to obtain a medicinal powder;

[0015] The remaining raw materials are boiled with water, filtered, the medicinal juice is collected, the medicinal juice is concentrated, and then the medicinal powder is added, stirred evenly, to obtain pills, and dried naturally.

[0016] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0017] The lipid-lowering and blood-clearing combination provided by the present invention has Panax notoginseng, Salvia miltiorrhiza, stir-fried Cassia seed, Hawthorn, stir-fried Atractylodes macrocephala as main ingredients, and is combined with Polygonum multiflorum and Pheretima. The combination has the effects of lowering blood lipids, resisting thrombosis, and lowering cholesterol, can remove "garbage" from the blood vessel wall, and has a good therapeutic effect on atherosclerosis and fatty liver. The saponin components contained in Panax notoginseng are related to the blood circulation effect, can increase the activity of antioxidant enzymes, thereby inhibiting lipid peroxidation, and long-term use has the effect of lowering blood lipids.

[0018] On the other hand, the composition provided in the embodiments of the present invention can be used in combination with drugs for treating angina pectoris, without the side effects of general vasodilators. When patients take some vasodilator drugs such as nifedipine, isothiocyanate, danshen tablets, etc., and then take the composition of the present invention, they will not experience symptoms such as headache, dizziness, severe skin itching, and the angina pectoris will also be controlled. DETAILED DESCRIPTION

[0019] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0020] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other. The present invention will be described in detail below with reference to specific embodiments.

[0021] On the one hand, an embodiment of the present invention provides a lipid-lowering and meridian-opening composition, which includes the following raw materials by weight: 1-3 parts of Panax notoginseng, 2-5 parts of Salvia miltiorrhiza, 3-6 parts of stir-fried Cassia seeds, 4-6 parts of Hawthorn, 3-6 parts of stir-fried Atractylodes macrocephala, 1-3 parts of Polygonum multiflorum, and 1-3 parts of Pheretima.

[0022] Panax notoginseng can dissipate blood stasis, stop bleeding, reduce swelling and relieve pain. Long-term use can achieve a certain effect of lowering blood lipids. The saponins in Panax notoginseng are related to the effect of promoting blood circulation, which can increase the activity of antioxidant enzymes, thereby inhibiting lipid peroxidation and reducing the occurrence of cardiovascular diseases caused by hyperlipidemia.

[0023] Purple salvia miltiorrhiza has the effects of promoting blood circulation and regulating menstruation, removing blood stasis and relieving pain, cooling blood and eliminating carbuncle, clearing the heart and eliminating troubles, nourishing blood and calming the mind. Purple salvia miltiorrhiza can act on the circulatory system, dilate coronary arteries, improve myocardial blood supply, and reduce blood lipids.

[0024] Fried Cassia Seed has multiple effects such as clearing away heat and detoxifying, moistening the intestines and relieving constipation, lowering blood pressure, lowering blood lipids, and lowering blood sugar. Fried Cassia Seed has the effect of lowering blood lipids for people with high blood lipids, and helps prevent cardiovascular diseases. The Fried Cassia Seed used in the embodiment of the present invention, its processing technology is: the cleaned Cassia Seed is placed in a hot pot and fried with medium heat. During the frying process, the color and state of the Cassia Seed are observed, and when the color deepens, there is a slight popping sound, it is slightly bulging, the interior is yellow, and the aroma escapes, it can be taken out and cooled. The fried Cassia Seed can alleviate its cold diarrhea, make its texture crisp, easy to crush and fry the effective ingredients, and enhance its effect of calming the liver and nourishing the kidneys.

[0025] Hawthorn has the effects of digesting food, removing stagnation, promoting qi and removing blood stasis. Hawthorn contains flavonoids, which have a certain effect of lowering blood lipids, and also have a certain auxiliary effect on cardiovascular and lowering blood pressure. In the formula provided by the present invention, hawthorn is combined with Panax notoginseng, Salvia miltiorrhiza and stir-fried Cassia seed as auxiliary ingredients to improve the overall effect of the composition on lowering blood lipids.

[0026] Atractylodes macrocephala has the effects of nourishing the middle and drying dampness, quenching thirst and promoting the production of body fluid, benefiting the spleen and essence, and nourishing the stomach qi. Atractylodes macrocephala can reduce hyperlipidemia and reduce fat deposition. The stir-fried Atractylodes macrocephala used in the embodiment of the present invention is prepared by the following method: put the stove core soil powder into a pot, stir-fry until the soil powder is loose and flexible, put in the Atractylodes macrocephala slices, stir-fry until the surface is covered with soil color, take out, and sieve out the soil powder.

[0027] Polygonum multiflorum has the functions of nourishing liver and kidney, improving blood and essence, blackening hair, strengthening tendons and bones, etc. Polygonum multiflorum is rich in lecithin, which can inhibit the deposition of cholesterol in the body and reduce serum cholesterol content, thereby playing a role in lowering blood lipids and preventing arteriosclerosis.

[0028] Earthworms have the effects of clearing away heat and calming the nerves, unblocking meridians, relieving asthma and promoting diuresis. They are often used to promote blood circulation and remove blood stasis. As an auxiliary drug, they can enhance the therapeutic effect of the combination.

[0029] In some embodiments of the present invention, the following raw materials are included by weight: 3 parts of Panax notoginseng, 5 parts of Salvia miltiorrhiza, 6 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

[0030] In some embodiments of the present invention, the following raw materials are included by weight: 3 parts of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 3 parts of Polygonum multiflorum, and 3 parts of Pheretima.

[0031] In some embodiments of the present invention, the following raw materials are included by weight: 1 part of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 6 parts of hawthorn, 6 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

[0032] On the other hand, an embodiment of the present invention provides a method for preparing a lipid-lowering and blood-clearing composition, comprising the following steps: sterilizing each raw material at high temperature, drying, and then crushing Panax notoginseng and Salvia miltiorrhiza to obtain a medicinal powder;

[0033] The remaining raw materials are boiled with water, filtered, the medicinal juice is collected, the medicinal juice is concentrated, and then the medicinal powder is added, stirred evenly, to obtain pills, and dried naturally.

[0034] It should be noted that when preparing the composition provided in the embodiment of the present invention, each is crushed to a particle size between 0.1-0.5 mm. For the Jiangzhi Tongmai Pill of the present invention, the method of taking it is 6-8 g each time, twice a day, once in the morning and once in the evening.

[0035] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0036] Example 1

[0037] Prepare the raw materials according to the following ratio:

[0038] 3 parts of Panax notoginseng, 5 parts of Salvia miltiorrhiza, 6 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

[0039] After sterilizing the raw materials at high temperature, drying them, crushing the notoginseng and salvia miltiorrhiza into powder, adding them into a grinder, and crushing them into powder with a particle size of 0.1-0.5 mm to obtain medicinal powder;

[0040] The remaining raw materials are boiled with water, filtered, the medicinal juice is collected, the medicinal juice is concentrated, and then the medicinal powder is added, stirred evenly, kneaded and squeezed to form pills. Each pill weighs 1-1.2g.

[0041] Example 2

[0042] Prepare the raw materials according to the following ratio:

[0043] 3 parts of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 3 parts of Polygonum multiflorum, and 3 parts of Pheretima.

[0044] After sterilizing the raw materials at high temperature, drying them, crushing the notoginseng and salvia miltiorrhiza into powder, adding them into a grinder, and crushing them into powder with a particle size of 0.1-0.5 mm to obtain medicinal powder;

[0045] The remaining raw materials are boiled with water, filtered, the medicinal juice is collected, the medicinal juice is concentrated, and then the medicinal powder is added, stirred evenly, kneaded and squeezed to form pills. Each pill weighs 1-1.2g.

[0046] Example 3

[0047] Prepare the raw materials according to the following ratio:

[0048] 1 part of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 6 parts of Crataegus, 6 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

[0049] After sterilizing the raw materials at high temperature, drying them, crushing the notoginseng and salvia miltiorrhiza into powder, adding them into a grinder, and crushing them into powder with a particle size of 0.1-0.5 mm to obtain medicinal powder;

[0050] The remaining raw materials are boiled with water, filtered, the medicinal juice is collected, the medicinal juice is concentrated, and then the medicinal powder is added, stirred evenly, kneaded and squeezed to form pills. Each pill weighs 1-1.2g.

[0051] Example 4

[0052] Prepare the raw materials according to the following ratio:

[0053] 3 parts of Panax notoginseng, 3 parts of Salvia miltiorrhiza, 5 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

[0054] After sterilizing the raw materials at high temperature, drying them, crushing the notoginseng and salvia miltiorrhiza into powder, adding them into a grinder, and crushing them into powder with a particle size of 0.1-0.5 mm to obtain medicinal powder;

[0055] Add water to the remaining raw materials and boil, filter, collect the juice, concentrate the juice, add the powder, stir evenly, knead and squeeze to make pills. Each pill weighs 1-1.2g.

[0056] Example 5

[0057] Prepare the raw materials according to the following ratio:

[0058] 3 parts of Panax notoginseng, 5 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 5 parts of Crataegus, 5 parts of stir-fried Atractylodes macrocephala, 2.5 parts of Polygonum multiflorum, and 2.5 parts of Pheretima.

[0059] After sterilizing the raw materials at high temperature, drying them, crushing the notoginseng and salvia miltiorrhiza into powder, adding them into a grinder, and crushing them into powder with a particle size of 0.1-0.5 mm to obtain medicinal powder;

[0060] Add water to the remaining raw materials and boil, filter, collect the juice, concentrate the juice, add the powder, stir evenly, knead and squeeze to make pills. Each pill weighs 1-1.2g.

[0061] Typical Cases

[0062] Mr. Feng, male, 45 years old, irregular work, fat body, the results of blood lipid test in the hospital are: uric acid, triglyceride are higher than normal range, blood pressure: 165 / 100, self-report: headache, dizziness, unclear mind, weak body, just want to sleep, can't get up the spirit. After taking the Jiangzhitongmai Pills provided in Example 1 for three months, he felt relaxed, clear-headed and in good mental state; after continuing to take it for three months, the test results were compared: uric acid, triglyceride and other indicators were reduced to normal range, and after stopping the drug, he followed the doctor's advice: pay attention to diet, less salt and more vinegar, less meat and more vegetables, and no recurrence within 1 year.

[0063] In summary, the Zhitongmai composition and preparation method of the present invention are mainly composed of Panax notoginseng, Salvia miltiorrhiza, stir-fried Cassia seed, Crataegus pinnatifida, and stir-fried Atractylodes macrocephala, and are combined with Polygonum multiflorum and Pheretima. The composition has the effects of lowering blood lipids, resisting thrombosis, and lowering cholesterol, can remove the "garbage" in the blood vessel wall, and has a good effect on atherosclerosis and fatty liver. The saponin components contained in Panax notoginseng are related to the effect of promoting blood circulation, can increase the activity of antioxidant enzymes, thereby inhibiting lipid peroxidation, and long-term use has the effect of lowering blood lipids.

[0064] The composition of the present invention can be used together with drugs for treating angina pectoris, and has no side effects of general vasodilators. When patients take vasodilator drugs such as nifedipine, nifedipine, danshen tablets, etc., and then take the composition of the present invention, they will not experience symptoms such as headache, dizziness, severe skin itching, and the angina pectoris will also be controlled.

[0065] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

Claims

1. A lipid-lowering and blood vessel-opening composition, characterized in that: The following raw materials are included by weight: 1-3 parts of Panax notoginseng, 2-5 parts of Salvia miltiorrhiza, 3-6 parts of stir-fried Cassia seeds, 4-6 parts of Hawthorn, 3-6 parts of stir-fried Atractylodes macrocephala, 1-3 parts of Polygonum multiflorum, and 1-3 parts of Pheretima.

2. The lipid-lowering and meridian-opening composition according to claim 1, characterized in that: The following raw materials are included by weight: 3 parts of Panax notoginseng, 5 parts of Salvia miltiorrhiza, 6 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

3. The lipid-lowering and meridian-opening composition according to claim 1, characterized in that: The weight parts include the following raw materials: 3 parts of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 4 parts of Crataegus, 3 parts of stir-fried Atractylodes macrocephala, 3 parts of Polygonum multiflorum, and 3 parts of Pheretima.

4. The lipid-lowering and meridian-opening composition according to claim 1, characterized in that: The weight parts include the following raw materials: 1 part of Panax notoginseng, 2 parts of Salvia miltiorrhiza, 3 parts of stir-fried Cassia seeds, 6 parts of Crataegus, 6 parts of stir-fried Atractylodes macrocephala, 1 part of Polygonum multiflorum, and 1 part of Pheretima.

5. A method for preparing the lipid-lowering and meridian-opening composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: After sterilizing the raw materials at high temperature, drying them, and then crushing the notoginseng and salvia miltiorrhiza to obtain medicinal powder; The remaining raw materials are boiled with water, filtered, the medicinal juice is collected, the medicinal juice is concentrated, and then the medicinal powder is added, stirred evenly, to obtain pills, and dried naturally.