Method for preparing ultrahigh drug-loading compound by using post-crosslinking monodisperse encapsulation technology

Through the monodispersion technology after crosslinking, the problems of low drug loading and complex preparation process of protein polypeptide drugs were solved, and the preparation of ultra-high drug loading complex was achieved, and the drug loading volume was increased to 95.5%, simplifying the process and improving the Drug utilization.

CN119185564APending Publication Date: 2024-12-27ZHENJIANG HOSPITAL OF INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE (ZHENJIANG SECOND PEOPLES HOSPITAL)
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Patent Information

Application Number
CN202411319281.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-22
Publication Date
2024-12-27

AI Technical Summary

Technical Problem

The prior art has low drug loading, complex preparation process, uncontrollable release, and high dosage of auxiliary materials when preparing protein polypeptide drugs, resulting in limited drug application.

Method used

The post-crosslinking monodispersion technology is adopted to cross-link the electrostatic effect of the particles of the drug active ingredient and the charged carrier material. After removing the solvent, the composite is monodispersed in the aqueous phase, thereby realizing the preparation of ultra-high drug-loading complexes.

Benefits of technology

The drug loading volume has been significantly increased, the preparation process has been simplified, the drug utilization has been improved, the drug loading volume can reach up to 95.5%, and the application of protein and polypeptide drugs has been improved.

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Abstract

The invention discloses a method for preparing an ultrahigh drug-loading compound by using a post-crosslinking monodisperse encapsulation technology, which comprises the following steps: mixing a suspension containing active pharmaceutical ingredient particles with a solution containing a charged carrier material, so that the active pharmaceutical ingredient particles are crosslinked with the charged carrier material; removing the solvent to obtain a drug carrier crosslinking body; and dispersing the obtained drug carrier cross-linking body in a water phase to obtain the ultrahigh drug-loading compound. Based on the strong intermolecular interaction between the active drug and the polymer or lipid, the polymer or lipid is not only an active drug delivery carrier, but also a cross-linking component, and other cross-linking agents or other cross-linking conditions do not need to be additionally added. The prepared ultrahigh drug loading compound has the characteristics of good universality, high drug loading capacity and the like.
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Citation Information

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