Automatic medicine centrifugal screening machine and screening method

Abstract

The invention relates to the field of medicine screening, in particular to an automatic medicine centrifugal screening machine and a screening method.The screening machine comprises a centrifugal barrel and a separation barrel, a centrifugal mechanism is installed on the centrifugal barrel, and a centrifugal part is installed at the bottom of the centrifugal mechanism and used for achieving centrifugal movement of medicine particles; a backflow part is mounted at the top of the centrifugal part and used for adjusting wind power for blowing medicine particles; an air inlet mechanism is mounted at the bottom of the centrifugal part and is used for conveying external air into the separation barrel; a detection part is mounted on the side surface of the separation cylinder and is used for detecting granularity data of medicines falling into the separation cylinder; by detecting the separation condition of medicine particles in real time and adjusting the wind power and the wind direction for blowing the medicine, automatic multi-stage separation of the medicine is achieved, use of a screen is avoided, the production cost is reduced, continuous and automatic operation is achieved, and the production efficiency is improved.

Description

Technical Field

[0001] The invention relates to the field of drug screening, and in particular to an automatic drug centrifugal screening machine and a screening method. Background Art

[0002] Drug screening is an important part of the pharmaceutical process, which aims to obtain drugs with more uniform particle size to improve the uniformity of the mixture and the quality of the drug. Drug screening can screen out coarse particles or foreign matter, fine powder or impurities, and the whole grain can screen out coarse particles and fine powder to obtain products with more uniform particle size to meet the different requirements of pills, powders and other preparations. Currently, the screening equipment commonly used in the pharmaceutical process includes electromagnetic vibration screens, etc. These devices have the characteristics of high screening efficiency and are suitable for viscous drugs.

[0003] In the above-mentioned process of drug screening using a vibrating screen, due to the differences in parameters such as drug particle size, viscosity, density, etc., in order to meet the use requirements of various drug preparation processes, it is generally necessary to prepare screens of various mesh sizes as alternatives. This on the one hand leads to an increase in production costs, and on the other hand reduces the utilization rate of the screen, resulting in a waste of resources; in addition, continuous screening cannot be achieved through vibrating screening, and batch screening reduces production efficiency; in addition, the screen needs to be cleaned and maintained after being used for a period of time, which increases the extra workload and causes a waste of manpower and material resources. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides an automated drug centrifugal screening machine and screening method, which realizes the separation of drugs of different particle sizes by combining centrifugal separation with airflow, avoiding the high cost problem caused by the use of screens; by adjusting parameters such as wind power, continuous separation of drugs is achieved, solving the problem of low production efficiency caused by vibration screening. It is specifically achieved through the following technical solutions: The present invention discloses an automated drug centrifugal screening machine, comprising a centrifugal cylinder, the centrifugal cylinder is coaxially fixed with a separation cylinder, a plurality of material distribution chambers are arranged at the bottom of the separation cylinder, the material distribution chambers are respectively connected with the inner side of the top of the separation cylinder through channels, and a plurality of legs are fixed at the bottom of the separation cylinder; The centrifugal cylinder is provided with a centrifugal mechanism, which includes a centrifugal motor, the output end of the centrifugal motor is drivingly connected to the transmission shaft, a centrifugal part is coaxially installed at the bottom of the transmission shaft, the centrifugal part is used to realize the centrifugal movement of the drug particles, a plurality of swing leaves are rotatably installed at the top of the centrifugal part, a reflux part is installed at the top of the swing leaves, the reflux part is used to adjust the gap between the swing leaves, a reflux chamber is installed at the top of the reflux part, and the reflux chamber is used to collect drug particles with smaller particle sizes; The bottom of the centrifugal part is equipped with an air inlet mechanism that can reciprocate along the axial direction of the separation cylinder. The air inlet mechanism is used to transport external air into the separation cylinder. The air inlet mechanism includes a shaft sleeve and a flow equalizer that can move relative to each other, and is used to adjust the wind force at the air outlet of the air inlet mechanism. A detection unit is also installed on the side of the separation cylinder, and the detection unit is used to detect the particle size data of the medicine falling into the separation cylinder; The centrifugal mechanism, the reflux part, the air inlet mechanism and the detection part are respectively connected to the controller signal, and the controller is installed on the outside of the separation cylinder.

[0005] Preferably, the centrifugal mechanism further comprises a first pulley, the centrifugal cylinder is fixed to the centrifugal motor, the centrifugal motor is connected to the controller signal, the output end of the centrifugal motor is coaxially fixed to the first pulley, the first pulley is driven by a second pulley through a transmission belt, and the second pulley is coaxially fixed to the transmission shaft; The centrifugal part is rotatably mounted on a mounting plate, and the mounting plate is mounted in a centrifugal cylinder. A plurality of through holes are provided on the mounting plate, and the mounting plate is hinged to the first ends of a plurality of the swing leaves, and the second ends of the swing leaves are hinged to the top of the centrifugal cylinder, and the hinge shaft of the second end of the swing leaf passes through the top of the centrifugal cylinder and is drivingly connected to the reflux part, and the reflux part is sealed and arranged in a mounting chamber, and the mounting chamber is fixed to the top of the centrifugal cylinder, and the reflux chamber is mounted on the top of the mounting chamber, and the top of the reflux chamber is fixed to a feed plate, and the feed plate is fixedly connected to a feed channel, and the feed channel seal passes through the reflux chamber, the mounting chamber and the top of the centrifugal cylinder and is connected to the top of the centrifugal part, and an annular gap is arranged between the mounting chamber and the feed channel.

[0006] Preferably, the air inlet mechanism further comprises a positioning shaft, the positioning shaft is coaxially fixed to the bottom of the centrifugal part, the positioning shaft is outer-mounted with the shaft sleeve moving along its axial direction, a plurality of electric cylinders are installed on the outer side of the shaft sleeve, the electric cylinders are connected to the controller signal, and the output end of the electric cylinders is fixed to the flow equalizing plate; The flow balancing plate is provided with a plurality of guide holes, the guide holes are provided with guide rods moving along the guide holes, the guide rods are fixed to the shaft sleeve, the flow balancing plate is coaxially fixed to the connecting pipe, the connecting pipe is fixed to the guide pipe, an air supply pipe moving along the guide pipe is sealed and provided in the guide pipe, the air supply pipe is fixedly connected to the fan, and the fan is installed on the separation cylinder; The guide tube is also sealed and slidably arranged in a through hole opened at the bottom of the separation cylinder. The guide tube is threadedly connected to a screw rod, which is coaxially fixed to an output end of a first motor. The first motor is signal-connected to the controller, and the first motor is fixed to the separation cylinder.

[0007] Preferably, the centrifugal part includes a support plate, the transmission shaft is coaxially fixed to the support plate, a plurality of partitions are fixed on the support plate, through holes are formed on the partitions, the partitions are fixed to a top plate, a connecting hole is coaxially formed on the top plate, and the connecting hole is aligned with and connected to the feed channel.

[0008] Preferably, the reflux part includes an electric telescopic rod, the centrifugal cylinder is hinged to the first end of the electric telescopic rod, the electric telescopic rod is connected to the controller signal, the second end of the electric telescopic rod is hinged to the driving gear, the driving gear is rotatably mounted on the centrifugal cylinder, the driving gear is simultaneously meshed with a plurality of driven gears, and the plurality of driven gears are respectively coaxially fixed to the hinge shaft of the centrifugal cylinder passing through the top of the swing leaf.

[0009] Preferably, the detection unit includes a driving motor, the separation cylinder is fixed to the driving motor, the output end seal of the driving motor passes through the side wall of the separation cylinder and is fixed to the driving shaft of the valve, the valve is installed on the top of the sampling tube, the middle part of the sampling tube passes through the side wall of the separation cylinder, a laser probe is fixedly installed on the bottom side of the sampling tube, the laser probe is electrically connected to the laser particle size detector, the laser particle size detector is connected to the controller signal, the bottom discharge port of the sampling tube is located directly above the collecting box, and the collecting box is fixed to the separation cylinder.

[0010] Preferably, the through hole formed on the mounting plate is located at a position of the mounting plate close to the inner circumferential surface of the centrifugal barrel.

[0011] Preferably, the cross-sectional shape of the outer surface of the guide tube is a square, and the through hole opened at the bottom of the separation cylinder is a square matching the cross-sectional shape of the outer surface of the guide tube.

[0012] Preferably, the cross-sectional shape of the guide rod is a square, and the cross-sectional shape of the guide hole provided on the flow equalizing plate is a square matching the cross-sectional shape of the guide rod.

[0013] The present invention also provides an automated drug centrifugal screening method, comprising the following steps: S1. Determine the particle size range of drug particle screening, the particle size of drug particles entering the reflux chamber is within a first particle size range, the particle size of drug particles entering the channel is within a second particle size range, and the particle size of drug particles entering the separation cylinder is within a third particle size range; S2, the controller controls the first motor to drive the screw to rotate, adjusts the guide tube to the lowest position and controls the centrifugal motor and the fan to start; S3, start adding the drug particles to be screened into the feed tray, and control the driving motor to drive the valve to open through the controller, the laser probe collects the particle size information of the drug particles falling into the sampling tube, and calculates the particle size distribution information of the sample through the laser particle size detector; S4, classifying and calculating the percentage of the particle size distribution information of the sample according to the first particle size range, the second particle size range and the third particle size range; When the percentage of particles in the first particle size range is greater than 2%, the controller controls the electric telescopic rod to extend and retract, and the gap between adjacent swing leaves is reduced. When the percentage of particles in the first particle size range is less than 1%, the controller controls the electric telescopic rod to extend and retract, and the gap between adjacent swing leaves is increased. Finally, through adjustment, the percentage of particles in the first particle size range of the drug particles falling into the separation cylinder is stabilized at 1% to 2%. After the above process adjustment is completed, the controller controls the drive motor to drive the valve to close; S5, the controller controls the first motor to rotate and drive the guide tube to move upward, so that the gap between the shaft sleeve and the flow equalizing plate is aligned with the entrances of the plurality of channels; S6, the controller controls the driving motor to drive the valve to open, the laser probe collects the particle size information of the drug particles falling into the sampling tube, and calculates the particle size distribution information of the sample through the laser particle size detector; S7, classifying and calculating the percentage of the particle size distribution information of the sample according to the first particle size range, the second particle size range and the third particle size range; When the percentage of particles in the third particle size range is less than 98%, the controller controls the electric cylinder to reduce the gap between the sleeve and the flow plate. When the percentage of particles in the third particle size range is greater than 99%, the controller controls the electric cylinder to increase the gap between the sleeve and the flow plate. Finally, through adjustment, the percentage of particles in the third particle size range of the drug particles falling into the separation cylinder is stabilized at 98% to 99%. After the above process adjustment is completed, the controller controls the drive motor to drive the valve to close; S8. After the screening is completed, the drug particles discharged from the reflux chamber are collected as drug particles in the first particle size range, the drug particles in several material distribution chambers are collected as drug particles in the second particle size range, and the drug particles in the separation cylinder are collected as drug particles in the third particle size range. The operator obtains the final drug particles from the corresponding ranges according to different required ranges.

[0014] After adopting the above technical solution, the beneficial effects of the present invention are: 1. The present invention abandons the mesh screen and adopts a combination of centrifugal force and wind force to achieve the classification of drug particles, thereby avoiding the cost waste caused by traditional equipment with a large number of screens.

[0015] 2. By adjusting the wind force and the position of the air outlet, drug screening of various levels of particle size can be achieved at one time to meet the use requirements of multi-level screening.

[0016] 3. The screening process is carried out continuously and automatically adjusted, which not only improves production efficiency, but also reduces the workload of operators and reduces the waste of manpower and material resources.

[0017] 4. It can adapt to the screening needs of drugs with various particle sizes by adjusting parameters such as wind power, which increases the adaptability of the screening machine. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a structural schematic diagram of an automated drug centrifugal screening machine; Figure 2 for Figure 1 Side view of some parts in the middle; Figure 3 for Figure 1 Front cross-sectional view of some parts in the middle; Figure 4 for Figure 2 A rear cross-sectional view of Figure 5 It is a disassembled stereoscopic schematic diagram of the centrifugal mechanism; Figure 6 for Figure 5 A front cross-sectional view of Figure 7 It is a structural schematic diagram of the reflux part; Figure 8 It is a partial dissected stereoscopic diagram of the centrifugal part; Fig. 9 It is a partial dissected stereoscopic diagram of the air inlet mechanism; Fig.10 for Figure 4 A partial enlarged view of Fig.11 for Figure 3 A partial enlarged view of .

[0020] Description of reference numerals: 101 - centrifugal cylinder, 102 - separation cylinder, 103 - support leg, 104 - material distribution chamber, 105 - channel; 200 - centrifugal mechanism, 201 - centrifugal motor, 202 - first pulley, 203 - transmission belt, 204 - second pulley, 205 - transmission shaft, 206 - mounting plate, 207 - swing leaf, 208 - mounting chamber, 209 - reflux chamber, 210 - feed tray, 211 - feed channel; 300 - centrifugal part, 301 - support plate, 302 - partition plate, 303 - top plate, 304 - connecting hole; 400 - reflux part, 401 - electric telescopic rod, 402 - driving gear, 403 - driven gear; 500 - air inlet mechanism, 501 - positioning shaft, 502 - shaft sleeve, 503 - electric cylinder, 504 - flow equalizing plate, 505 - guide rod, 506 - connecting pipe, 507 - guide pipe, 508 - air supply pipe, 509 - fan, 510 - screw rod, 511 - first motor; 600 - detection unit, 601 - drive motor, 602 - valve, 603 - sampling tube, 604 - laser probe, 605 - laser particle size detector, 606 - collection box; 700 - Controller. DETAILED DESCRIPTION

[0021] The features and exemplary embodiments of various aspects of the present invention will be described in detail below. In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only configured to explain the present invention and are not configured to limit the present invention. For those skilled in the art, the present invention can be implemented without the need for some of these specific details. The following description of the embodiments is only to provide a better understanding of the present invention by illustrating examples of the present invention.

[0022] The directional words appearing in the following description are all directions shown in the figures, and do not limit the specific structure of the present invention. In the description of the present invention, it should also be noted that, unless otherwise clearly specified and limited, the terms "installation" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected or indirectly connected. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0023] The embodiment of the present invention provides an automated drug centrifugal screening machine, see Figures 1 to 4The automated drug centrifugal screening machine comprises a centrifugal cylinder 101, a separation cylinder 102, and a support leg 103. The bottom of the centrifugal cylinder 101 is coaxially fixedly connected to the top of the separation cylinder 102. A plurality of material distribution cavities 104 are annularly arranged at the bottom of the separation cylinder 102. The plurality of material distribution cavities 104 are coaxially sleeved, and the top of each material distribution cavity 104 is connected to the inner side of the top of the separation cylinder 102 through a channel 105.

[0024] A plurality of legs 103 are evenly fixed to the bottom of the separation cylinder 102 along its circumference to support the entire screening machine.

[0025] A centrifugal mechanism 200 is fixedly installed on the top of the centrifugal cylinder 101, which is used to drive the centrifugal part 300 to achieve centrifugal movement of the medicine. The centrifugal part 300 is installed on the lower side of the inside of the centrifugal cylinder 101, and a reflux part 400 is installed on the upper side of the inside of the centrifugal cylinder 101. The reflux part 400 is used to collect components with smaller particle size in the medicine that achieves centrifugal movement through the centrifugal part 300.

[0026] An air inlet mechanism 500 is installed inside the separation cylinder 102, and the air inlet mechanism 500 is used to transport external air to the bottom of the centrifugal part 300, so that the smaller particle size components in the medicine that have achieved centrifugal motion through the centrifugal part 300 are blown to the reflux part 400 under the action of wind to complete collection, thereby achieving separation of the small particle size components in the medicine.

[0027] A detection unit 600 is also installed on the side of the separation cylinder 102. The detection unit 600 is used for sampling detection and obtaining data on the particle size of the drugs falling into the separation cylinder 102. The wind force and direction of the air supplied by the air inlet mechanism 500 are adjusted in real time according to the data to achieve secondary classification of the drugs falling into the separation cylinder 102, so as to ensure that the particle size of the separated drugs meets the final use requirements.

[0028] The centrifugal mechanism 200, the reflux unit 400, the air inlet mechanism 500, and the detection unit 600 are respectively connected to the controller 700 by signal. The controller 700 is fixedly mounted on the outer surface of the separation cylinder 102. The controller 700 is used to realize the control and coordination of each mechanism.

[0029] The present invention can achieve separation of various particle grades in drugs through the above-mentioned mechanism. First, the centrifugal part 300 throws the drug particles to be separated outward, giving the drug particles centrifugal force and initial velocity, so that the drug particles disperse and move around from the axis of the centrifugal cylinder 101, and then blow air to the bottom of the centrifugal part 300 through the air inlet mechanism 500. Under the action of wind force, the drug particles are separated. The drug particles with smaller mass will float up under the action of wind force and enter the reflux part 400. The drug particles with larger particles will continue to move downward under the action of gravity and fall into the separation cylinder 102, thereby achieving the first separation of the drug particles, and this separation only removes the components with smaller particle size in the drug.

[0030] A portion of the drug particles that continue to move downward under the action of gravity enter the detection unit 600 for particle size measurement. The detection unit 600 can measure the range of particle sizes (i.e., it can measure the minimum particle size, the maximum particle size, and the proportion of the particle size range), and adjust the centrifugal mechanism 200, the reflux unit 400, the air inlet mechanism 500, and the detection unit 600 through the controller 700 according to the measurement data and actual use requirements, so that the final drug particle size meets the use requirements.

[0031] For further explanation of the present invention, see Figure 2 , 3 , 5, 6, the centrifugal mechanism 200 includes a centrifugal motor 201, a first pulley 202, a transmission belt 203, a second pulley 204, a transmission shaft 205, a mounting plate 206, a swing leaf 207, a mounting chamber 208, a reflux chamber 209, a feed tray 210, and a feed channel 211; The side of the centrifugal cylinder 101 is fixedly connected to the centrifugal motor 201, the centrifugal motor 201 is connected to the controller 700 by signal, the output end of the centrifugal motor 201 is coaxially fixed to the first pulley 202, the first pulley 202 is connected to the second pulley 204 by a transmission belt 203, the second pulley 204 is coaxially fixed to the first end of the transmission shaft 205, the transmission shaft 205 is rotatably installed in the centrifugal cylinder 101, and the second end of the transmission shaft 205 is coaxially installed with a centrifugal part 300.

[0032] The top of the centrifugal part 300 is rotatably mounted on the mounting plate 206, and the mounting plate 206 is fixedly mounted on the inner circumferential surface of the centrifugal cylinder 101. A plurality of through holes are evenly opened on the mounting plate 206 along its circumference, so that the gas below the centrifugal part 300 can smoothly pass through the through holes into the reflux part 400. The mounting plate 206 is hinged to the first ends of a plurality of swing leaves 207, and the second ends of the swing leaves 207 are hinged to the top of the centrifugal cylinder 101. The hinge shaft of the second end of the swing leaf 207 passes through the top of the centrifugal cylinder 101 and is drivingly connected to the reflux part 400. The part 400 is sealed and arranged in the installation chamber 208, the installation chamber 208 is fixedly connected to the top of the centrifugal cylinder 101, a reflux chamber 209 is fixedly installed on the top of the installation chamber 208, the top of the reflux chamber 209 is fixedly connected to the feed plate 210, the middle part of the feed plate 210 is fixed to and communicated with the first end of the feed channel 211, the feed channel 211 seals through the reflux chamber 209, the installation chamber 208 and the top of the centrifugal cylinder 101 and is communicated with the top of the centrifugal part 300, and an annular gap is arranged between the installation chamber 208 and the feed channel 211.

[0033] Among them, the through hole opened on the mounting plate 206 is located at a position of the mounting plate 206 close to the inner circumferential surface of the centrifugal cylinder 101, that is, biased towards the side of the mounting plate 206 away from the axis, so as to facilitate the gas below the centrifugal part 300 to enter the reflux part 400 through the mounting plate 206.

[0034] like Figure 8 As shown, the centrifugal part 300 includes a support plate 301, a partition plate 302, a top plate 303, and a connecting hole 304. The second end of the transmission shaft 205 is coaxially fixed to the middle part of the support plate 301. The support plate 301 is evenly fixed with a plurality of radially arranged partition plates 302 along its circumference. The partition plates 302 are provided with a plurality of through holes for reducing the wind resistance of the centrifugal part 300 during rotation, so as to facilitate the rotation of the centrifugal part 300 and thereby throw the drug particles outward. The top of the partition plate 302 is fixedly connected to the top plate 303, and the top plate 303 is coaxially arranged with the support plate 301. A connecting hole 304 is coaxially provided in the middle part of the top plate 303, and the connecting hole 304 is aligned with and communicated with the second end of the feed channel 211, so that the drug particles in the feed tray 210 can be smoothly transported to between the support plate 301 and the top plate 303 along the feed channel 211 under the action of gravity.

[0035] Also, see Figure 7 The reflux section 400 includes an electric telescopic rod 401, a driving gear 402, and a driven gear 403. The top of the centrifugal barrel 101 is hinged to the first end of the electric telescopic rod 401. The electric telescopic rod 401 is connected to the controller 700 by signal. The second end of the electric telescopic rod 401 is hinged to the driving gear 402. The driving gear 402 is rotatably installed on the top of the centrifugal barrel 101. The driving gear 402 is meshed with a plurality of driven gears 403 along the circumferential direction at the same time. The plurality of driven gears 403 are respectively coaxially fixed with the hinge shaft of the top of the swing leaf 207 passing through the centrifugal barrel 101.

[0036] In the above-mentioned embodiment of the present invention, the start, stop and rotation speed of the centrifugal motor 201 are first controlled by the controller 700. The centrifugal motor 201 further drives the rotation of the transmission shaft 205 and the centrifugal part 300 through the transmission relationship among the first pulley 202, the transmission belt 203 and the second pulley 204. The rotation of the centrifugal part 300 drives the rotation of the support plate 301 through the transmission shaft 205. The drug particles in the feed tray 210 slide to the upper surface of the support plate 301 through the feed channel 211, and are thrown outward from a position close to the axis of the support plate 301 under the rotation of the support plate 301. On the one hand, the uniform dispersion of the drug particles is achieved, which facilitates the classification of the drug particles. On the other hand, due to the difference in the size of the drug particles, the speed at which different particles are thrown out is different. The larger particles are thrown out faster, and the smaller particles are thrown out slower, which facilitates the classification of the drug particles.

[0037] After the drug particles are thrown out through the centrifugal part 300, under the action of the air inlet mechanism 500, the drug particles are affected by the wind force in the process of moving outward from the axis of the support plate 301 to the inner wall of the centrifugal cylinder 101. At this time, the drug particles are affected by gravity on the one hand, which acts vertically downward, and by the blowing force of the wind on the other hand, which acts almost vertically upward. Therefore, when the blowing force of the wind is greater than the gravity of the drug particles, the drugs can flow with the wind to the reflux part 400 located above the centrifugal part 300. Otherwise, the drug particles will slide down along the inner wall of the centrifugal cylinder 101 after hitting the side wall of the centrifugal cylinder 101. Therefore, by controlling the size of the wind force of the air inlet mechanism 500, the size of the drug particles entering the reflux part 400 can be controlled, thereby achieving the first effective screening of the drugs.

[0038] In addition, the reflux portion 400 can drive the driving gear 402 to rotate in the forward and reverse directions along its axis through the extension and retraction of the electric telescopic rod 401, and the rotation of the driving gear 402 can further drive the driven gear 403 and the swing leaf 207 to rotate around the axis of the hinge axis of the swing leaf 207 through the meshing relationship between the driving gear 402 and the driven gear 403. Since a plurality of swing leaves 207 are evenly arranged between the top of the centrifugal cylinder 101 and the mounting plate 206, a plurality of swing leaves 207 are distributed in a centrally scattered manner. At this time, when the direction of the swing leaf 207 is aligned with the diameter of the mounting plate 206, When overlapped, the gap between two adjacent swing leaves 207 is the largest. When the direction of the swing leaves 207 deviates from the diameter of the mounting plate 206, the larger the deviation angle, the smaller the gap between the two adjacent swing leaves 207. Therefore, by controlling the extension and retraction of the electric telescopic rod 401 through the controller 700, the gap between several swing leaves 207 can be ultimately adjusted. When the air supply volume of the air inlet mechanism 500 remains fixed, the gap between the swing leaves 207 is adjusted, and the wind speed passing through the centrifugal part 300 and entering the reflux part 400 can be controlled. The faster the wind speed, the greater the blowing force on the drug particles.

[0039] In summary, by controlling the extension and retraction of the electric telescopic rod 401 through the controller 700 and then adjusting the gap between the swing leaves 207, the effect of drug particle screening can be achieved to a certain extent.

[0040] For further explanation of the present invention, see Figure 3 , 4, 9, 10, the air intake mechanism 500 includes a positioning shaft 501, a sleeve 502, an electric cylinder 503, a flow equalizing plate 504, a guide rod 505, a connecting pipe 506, a guide pipe 507, an air supply pipe 508, a fan 509, a screw 510, and a first motor 511. The bottom of the support plate 301 is coaxially fixed with the positioning shaft 501, and the outer side of the positioning shaft 501 is sleeved with a sleeve 502 that moves up and down along its axis, and the cross-sectional shape of the positioning shaft 501 is circular, and the cross-sectional shape of the sleeve 502 is a circular ring that matches the circle, so that the positioning shaft 501 plays a guiding role in the process of the sleeve 502 moving up and down.

[0041] The first ends of several electric cylinders 503 are evenly fixed on the outer surface of the sleeve 502 along the circumference, the electric cylinders 503 are connected to the controller 700 by signal, and the second ends of the electric cylinders 503 are fixedly connected to the outer surface of the current equalizing plate 504. The current equalizing plate 504 is evenly provided with several guide holes along its circumference, and a guide rod 505 is arranged in the guide hole to move along the guide hole. The first end of the guide rod 505 is fixedly connected to the bottom of the sleeve 502, and the cross-sectional shape of the guide rod 505 is square. The cross-sectional shape of the guide hole provided on the current equalizing plate 504 is square matching the cross-sectional shape of the guide rod 505, thereby ensuring that the sleeve 502 and the current equalizing plate 504 can only slide relative to each other along their axial directions.

[0042] In addition, the bottom of the sleeve 502 is set to an inverted cone shape, the flow equalizing plate 504 is set to a funnel shape, and the flow equalizing plate 504 can fit with the bottom of the sleeve 502. Therefore, by controlling the simultaneous extension and retraction of several electric cylinders 503 through the controller 700, the gap between the sleeve 502 and the flow equalizing plate 504 can be adjusted.

[0043] The flow equalizing plate 504 is coaxially fixed and connected to the first end of the connecting tube 506, the second end of the connecting tube 506 is fixedly connected and connected to the first end of the guide tube 507, the guide tube 507 is sealed with the first end of the air supply tube 508 moving along it, the second end of the air supply tube 508 is fixed and connected to the air outlet of the fan 509, and the fan 509 is fixedly installed at the bottom of the separation cylinder 102.

[0044] The guide tube 507 is also sealed and slidably arranged in the through hole opened at the bottom of the separation cylinder 102. The cross-sectional shape of the outer surface of the guide tube 507 is square. The through hole opened at the bottom of the separation cylinder 102 is a square that matches the cross-sectional shape of the outer surface of the guide tube 507, which guides the up and down movement of the guide tube 507.

[0045] The outer surface of the guide tube 507 is threadedly connected to the screw rod 510 , the screw rod 510 is coaxially fixed with the output end of the first motor 511 , and the first motor 511 is signal-connected to the controller 700 .

[0046] Through the above structure, the present invention can, on the one hand, adjust the distance between the shaft sleeve 502 and the equalizing plate 504. Under the premise of keeping the air flow rate of the fan 509 pumping unchanged, changing the distance between the shaft sleeve 502 and the equalizing plate 504 can adjust the wind speed blown out through the gap between the shaft sleeve 502 and the equalizing plate 504, that is, the larger the gap between the shaft sleeve 502 and the equalizing plate 504, the slower the wind speed, and the smaller the gap between the shaft sleeve 502 and the equalizing plate 504, the faster the wind speed. By adjusting the wind speed, the specific level of drug screening can be adjusted; on the other hand, the controller 700 can control the forward or reverse rotation of the screw 510 through the first motor 511 to realize the up and down movement of the guide tube 507 relative to the bottom of the separation cylinder 102, and the guide tube 507 will synchronously drive the shaft sleeve 502 and the equalizing plate 504 to move up and down during the up and down movement. At this time, the air inlet position of the air inlet mechanism 500 is changed, such as Figure 4 As shown, when the air inlet position of the air inlet mechanism 500 is close to the bottom of the separation cylinder 102, it is blocked by the side wall of the separation cylinder 102. After entering the separation cylinder 102, the external wind will begin to rise along the side wall of the separation cylinder 102. When it moves to the horizontal position where the centrifugal part 300 is located, the wind direction is basically vertically upward; on the contrary, when the air inlet position of the air inlet mechanism 500 is close to the bottom of the centrifugal part 300, at this time, due to the conical structure of the sleeve 502 and the flow equalizing plate 504, the wind direction at the air outlet position is from bottom to top and from the center to the surroundings. At this time, the wind direction has a blowing force on the inner wall of the separation cylinder 102 for the drug particles falling vertically downward, so that some components with smaller particle size will no longer slide vertically downward under the action of the blowing force, but enter the channel 105, and slide along the side wall of the channel 105 to different material distribution chambers 104. Therefore, the size of the drug particles in the material distribution chamber 104 is arranged in a decreasing order from the inside to the outside, thereby realizing the second classification of the drug particles.

[0047] In addition, during the process of adjusting the air outlet position of the air inlet mechanism 500, the gap between the shaft sleeve 502 and the flow equalizing plate 504 can be adjusted at any time, thereby simultaneously controlling the size of the wind force at the air outlet position, ensuring more accurate control of the second classification of the drug particles.

[0048] By utilizing the above structure, the device can be adapted to the screening selection of various products and various particle sizes, and the operator can obtain the final target product from different material distribution chambers 104 according to the particle size of the specific drug particles to be used.

[0049] For further explanation of the present invention, see Figure 1 , 3 , 11, the detection unit 600 includes a driving motor 601, a valve 602, a sampling tube 603, a laser probe 604, a laser particle size detector 605, and a collection box 606; The side of the separation cylinder 102 is fixedly connected to the driving motor 601, and the output end seal of the driving motor 601 passes through the side wall of the separation cylinder 102 and is coaxially fixed to the driving shaft of the valve 602. The valve 602 is installed on the top of the sampling tube 603. The middle part of the sampling tube 603 passes through the side wall of the separation cylinder 102 and is tilted. The tilt direction is from top to bottom from the axis of the separation cylinder 102 to the periphery of the separation cylinder 102, thereby ensuring that when the driving motor 601 drives the valve 602 to open, the drug particles sliding down can enter the sampling tube 603 and be transmitted to the outside of the separation cylinder 102 through the sampling tube 603 to complete the sampling.

[0050] A laser probe 604 is fixedly installed on the side of the bottom position of the sampling tube 603. The detection end of the laser probe 604 passes through the side wall of the sampling tube 603 and is arranged inside the sampling tube 603. The laser probe 604 is electrically connected to the laser particle size detector 605. The laser particle size detector 605 is signal-connected to the controller 700. The bottom discharge port of the sampling tube 603 is located directly above the collecting box 606, and the collecting box 606 is fixedly connected to the separation cylinder 102.

[0051] Among them, the laser particle size detector 605 can control the laser probe 604 to emit laser signals and collect laser scattering signals, and collect and calculate the size of drug particles based on the collected laser scattering signals. Its working principle is: when the laser is irradiated on the particles, the particles will diffract and scatter. The intensity and angle of the scattered light are related to factors such as the size, shape, and refractive index of the particles. The instrument collects and analyzes the scattered light signals, and uses mathematical models and algorithms to convert the scattered light distribution into particle size distribution information. This method is a prior art and will not be described in detail here.

[0052] The working mode of the above mechanism is: when it is necessary to perform particle size detection and analysis on the drug particles falling into the separation cylinder 102, the controller 700 controls the drive motor 601 to drive the valve 602 to rotate, and the falling drug particles fall into the sampling tube 603 through the valve 602, and slide down along the sampling tube 603. During the sliding process, they are detected by the laser probe 604, and the particle size distribution information of the sample is calculated by the laser particle size detector 605. The reflux part 400 and the air inlet mechanism 500 are adjusted according to the obtained particle size distribution information to achieve accurate classification of the drug particles.

[0053] The present invention provides an automated drug centrifugal screening method, which uses the automated centrifugal screening machine to screen drug particles, and the specific operating steps are as follows: S1. Determine the particle size range of drug particle screening. The particle size of drug particles entering the reflux chamber 209 is within a first particle size range, the particle size of drug particles entering the channel 105 is within a second particle size range, and the particle size of drug particles entering the separation cylinder 102 is within a third particle size range; The operator divides the screening range according to the actual screening needs and provides parameters for the adjustment process in subsequent screening, so as to facilitate the acquisition of the final product with the target particle size.

[0054] S2, the controller 700 controls the first motor 511 to drive the screw 510 to rotate, adjusts the guide tube 507 to the lowest position and controls the centrifugal motor 201 and the fan 509 to start; At the beginning of screening, it is necessary to first improve the screening accuracy of drug particles in the first size range. At this time, the guide tube 507 is adjusted to the lowest position, and particles in the second and third size ranges are not screened.

[0055] S3, start adding the drug particles to be screened into the feed tray 210, and control the driving motor 601 through the controller 700 to drive the valve 602 to open, the laser probe 604 collects the particle size information of the drug particles falling into the sampling tube 603, and calculates the particle size distribution information of the sample through the laser particle size detector 605; S4, classifying and calculating the percentage of the particle size distribution information of the sample according to the first particle size range, the second particle size range and the third particle size range; When the percentage of particles in the first particle size range is greater than 2%, the controller 700 controls the electric telescopic rod 401 to extend or retract, thereby reducing the gap between adjacent swing leaves 207. When the percentage of particles in the first particle size range is less than 1%, the controller 700 controls the electric telescopic rod 401 to extend or retract, thereby increasing the gap between adjacent swing leaves 207. Ultimately, through adjustment, the percentage of particles in the first particle size range among the drug particles falling into the separation cylinder 102 is stabilized at 1% to 2%.

[0056] After the above process adjustment is completed, the controller 700 controls the driving motor 601 to drive the valve 602 to close.

[0057] S5, the controller 700 controls the first motor 511 to rotate and drive the guide tube 507 to move upward, so that the gap between the sleeve 502 and the flow equalizing plate 504 is aligned with the entrances of the plurality of channels 105; By adjusting the guide tube 507 upward, the air outlet of the air inlet mechanism 500 is aligned with the inlets of the plurality of channels 105, thereby achieving screening of particles in the second size range and the third size range.

[0058] S6, the controller 700 controls the driving motor 601 to drive the valve 602 to open, the laser probe 604 collects the particle size information of the drug particles falling into the sampling tube 603, and calculates the particle size distribution information of the sample through the laser particle size detector 605; S7, classifying and calculating the percentage of the particle size distribution information of the sample according to the first particle size range, the second particle size range and the third particle size range; When the percentage of particles in the third particle size range is less than 98%, the controller 700 controls the electric cylinder 503 to reduce the gap between the sleeve 502 and the flow equalizing plate 504. When the percentage of particles in the third particle size range is greater than 99%, the controller 700 controls the electric cylinder 503 to increase the gap between the sleeve 502 and the flow equalizing plate 504. Finally, through adjustment, the percentage of particles in the third particle size range among the drug particles falling into the separation cylinder 102 is stabilized at 98% to 99%.

[0059] After the above process adjustment is completed, the controller 700 controls the driving motor 601 to drive the valve 602 to close.

[0060] S8. After the screening is completed, the drug particles discharged from the reflux chamber 209 are collected as drug particles in the first particle size range, the drug particles in the plurality of distribution chambers 104 are collected as drug particles in the second particle size range, and the drug particles in the separation cylinder 102 are collected as drug particles in the third particle size range. The operator obtains the final drug particles from the corresponding ranges according to the different required ranges.

[0061] According to the embodiments of the present invention as described above, these embodiments do not describe all the details in detail, nor do they limit the invention to specific embodiments. Obviously, many modifications and changes can be made based on the above description. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can make good use of the present invention and the modified use based on the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An automated drug centrifugal screening machine, comprising a centrifugal drum (101), characterized in that: The centrifugal cylinder (101) is coaxially fixed to the separation cylinder (102); a plurality of material distribution chambers (104) are provided at the bottom of the separation cylinder (102); the material distribution chambers (104) are respectively connected to the inner side of the top of the separation cylinder (102) through channels (105); and a plurality of supporting legs (103) are fixed to the bottom of the separation cylinder (102); The centrifugal cylinder (101) is provided with a centrifugal mechanism (200), the centrifugal mechanism (200) comprising a centrifugal motor (201), the output end of the centrifugal motor (201) being drivingly connected to a transmission shaft (205), a centrifugal part (300) being coaxially mounted on the bottom of the transmission shaft (205), the centrifugal part (300) being used to achieve centrifugal movement of drug particles, a plurality of swing leaves (207) being rotatably mounted on the top of the centrifugal part (300), a reflux part (400) being mounted on the top of the swing leaves (207), the reflux part (400) being used to adjust the gap between the swing leaves (207), a reflux chamber (209) being mounted on the top of the reflux part (400), the reflux chamber (209) being used to collect drug particles of smaller particle size; An air inlet mechanism (500) capable of axially reciprocating along the separation cylinder (102) is installed at the bottom of the centrifugal part (300), the air inlet mechanism (500) being used to convey external air into the separation cylinder (102), the air inlet mechanism (500) comprising a shaft sleeve (502) and a flow equalizing plate (504) capable of relative movement, and being used to adjust the wind force at the air outlet of the air inlet mechanism (500); A detection unit (600) is also installed on the side of the separation cylinder (102), and the detection unit (600) is used to detect the particle size data of the medicine falling into the separation cylinder (102); The centrifugal mechanism (200), the reflux part (400), the air inlet mechanism (500), and the detection part (600) are respectively connected to a controller (700) by signals, and the controller (700) is installed on the outside of the separation cylinder (102).

2. The automated drug centrifugal screening machine according to claim 1, characterized in that: The centrifugal mechanism (200) further comprises a first pulley (202), the centrifugal cylinder (101) is fixed to the centrifugal motor (201), the centrifugal motor (201) is signal-connected to the controller (700), the output end of the centrifugal motor (201) is coaxially fixed to the first pulley (202), the first pulley (202) is driven by a second pulley (204) through a transmission belt (203), and the second pulley (204) is coaxially fixed to the transmission shaft (205); The centrifugal part (300) is rotatably mounted on a mounting plate (206), the mounting plate (206) being mounted in a centrifugal cylinder (101), a plurality of through holes being provided on the mounting plate (206), the mounting plate (206) being hinged to the first ends of a plurality of swing leaves (207), the second ends of the swing leaves (207) being hinged to the top of the centrifugal cylinder (101), the hinge shaft at the second end of the swing leaf (207) passing through the top of the centrifugal cylinder (101) and being drivingly connected to the reflux part (400), the reflux part (400) being sealed and arranged in the mounting chamber (208), The installation chamber (208) is fixed to the top of the centrifugal cylinder (101); the reflux chamber (209) is installed on the top of the installation chamber (208); the top of the reflux chamber (209) is fixed to a feed plate (210); the feed plate (210) is fixedly connected to a feed channel (211); the feed channel (211) is sealed and passes through the reflux chamber (209), the installation chamber (208) and the top of the centrifugal cylinder (101) to be connected to the top of the centrifugal part (300); and an annular gap is provided between the installation chamber (208) and the feed channel (211).

3. The automated drug centrifugal screening machine according to claim 1, characterized in that: The air inlet mechanism (500) further comprises a positioning shaft (501), the positioning shaft (501) being coaxially fixed to the bottom of the centrifugal part (300), the outer sleeve of the positioning shaft (501) being provided with the shaft sleeve (502) moving along its axial direction, a plurality of electric cylinders (503) being mounted on the outer side of the shaft sleeve (502), the electric cylinders (503) being connected to the controller (700) via signals, and the output end of the electric cylinder (503) being fixed to the flow equalizing plate (504); The flow balancing plate (504) is provided with a plurality of guide holes, wherein guide rods (505) are arranged in the guide holes and move along the guide holes, wherein the guide rods (505) are fixed to the shaft sleeve (502), wherein the flow balancing plate (504) is coaxially fixed to the connecting pipe (506), wherein the connecting pipe (506) is fixed to the guide pipe (507), wherein an air supply pipe (508) is sealedly arranged in the guide pipe (507) and moves along the guide pipe, wherein the air supply pipe (508) is fixedly connected to a fan (509), and wherein the fan (509) is mounted on the separation cylinder (102); The guide tube (507) is also sealed and slidably arranged in a through hole opened at the bottom of the separation cylinder (102); the guide tube (507) is threadedly connected to the screw rod (510); the screw rod (510) is coaxially fixed to the output end of the first motor (511); the first motor (511) is signal-connected to the controller (700); and the first motor (511) is fixed to the separation cylinder (102).

4. The automated drug centrifugal screening machine according to claim 2, characterized in that: The centrifugal part (300) comprises a support plate (301), the transmission shaft (205) is coaxially fixed to the support plate (301), a plurality of partition plates (302) are fixed to the support plate (301), through holes are provided on the partition plates (302), the partition plates (302) are fixed to a top plate (303), a connecting hole (304) is coaxially provided on the top plate (303), and the connecting hole (304) is aligned with and communicated with the feed channel (211).

5. The automated drug centrifugal screening machine according to claim 1, characterized in that: The reflux portion (400) includes an electric telescopic rod (401), the centrifugal cylinder (101) is hinged to the first end of the electric telescopic rod (401), the electric telescopic rod (401) is signal-connected to the controller (700), the second end of the electric telescopic rod (401) is hinged to a driving gear (402), the driving gear (402) is rotatably mounted on the centrifugal cylinder (101), the driving gear (402) is simultaneously meshed with a plurality of driven gears (403), and the plurality of driven gears (403) are respectively coaxially fixed to a hinge shaft passing through the top of the swing leaf (207) of the centrifugal cylinder (101).

6. The automated drug centrifugal screening machine according to claim 1, characterized in that: The detection unit (600) comprises a drive motor (601), the separation cylinder (102) is fixed to the drive motor (601), the output end of the drive motor (601) is sealed and passes through the side wall of the separation cylinder (102) and is fixed to the drive shaft of the valve (602), the valve (602) is installed on the top of the sampling tube (603), the middle part of the sampling tube (603) passes through the side wall of the separation cylinder (102), a laser probe (604) is fixedly installed on the bottom side of the sampling tube (603), the laser probe (604) is electrically connected to the laser particle size detector (605), the laser particle size detector (605) is signal-connected to the controller (700), and the bottom discharge port of the sampling tube (603) is located directly above the collection box (606), and the collection box (606) is fixed to the separation cylinder (102).

7. The automated drug centrifugal screening machine according to claim 2, characterized in that: The through hole formed on the mounting plate (206) is located at a position of the mounting plate (206) close to the inner circumferential surface of the centrifugal cylinder (101).

8. The automated drug centrifugal screening machine according to claim 3, characterized in that: The cross-sectional shape of the outer surface of the guide tube (507) is a square, and the through hole provided at the bottom of the separation cylinder (102) is a square that matches the cross-sectional shape of the outer surface of the guide tube (507).

9. The automated drug centrifugal screening machine according to claim 3, characterized in that: The cross-sectional shape of the guide rod (505) is a square, and the cross-sectional shape of the guide hole provided on the flow equalizing plate (504) is a square matching the cross-sectional shape of the guide rod (505).

10. An automated drug centrifugal screening method, characterized in that: The following steps are involved: S1. Determine the particle size range for drug particle screening, the particle size of the drug particles entering the reflux chamber (209) is within a first particle size range, the particle size of the drug particles entering the channel (105) is within a second particle size range, and the particle size of the drug particles entering the separation cylinder (102) is within a third particle size range; S2, the controller (700) controls the first motor (511) to drive the screw (510) to rotate, adjusts the guide tube (507) to the lowest position, and controls the centrifugal motor (201) and the fan (509) to start; S3, starting to add the drug particles to be screened into the feed tray (210), and controlling the driving motor (601) through the controller (700) to drive the valve (602) to open, the laser probe (604) to collect the particle size information of the drug particles falling into the sampling tube (603), and calculating the particle size distribution information of the sample through the laser particle size detector (605); S4, classifying and calculating the percentage of the particle size distribution information of the sample according to the first particle size range, the second particle size range and the third particle size range; When the percentage of particles in the first particle size range is greater than 2%, the controller (700) controls the electric telescopic rod (401) to extend and retract, thereby reducing the gap between adjacent swing leaves (207); when the percentage of particles in the first particle size range is less than 1%, the controller (700) controls the electric telescopic rod (401) to extend and retract, thereby increasing the gap between adjacent swing leaves (207); and finally, through adjustment, the percentage of particles in the first particle size range among the drug particles falling into the separation cylinder (102) is stabilized at 1% to 2%. After the above process adjustment is completed, the controller (700) controls the driving motor (601) to drive the valve (602) to close; S5, the controller (700) controls the first motor (511) to rotate and thereby drives the guide tube (507) to move upward, so that the gap between the shaft sleeve (502) and the flow equalizing plate (504) is aligned with the entrances of the plurality of channels (105); S6, the controller (700) controls the driving motor (601) to drive the valve (602) to open, the laser probe (604) collects the particle size information of the drug particles falling into the sampling tube (603), and calculates the particle size distribution information of the sample through the laser particle size detector (605); S7, classifying and calculating the percentage of the particle size distribution information of the sample according to the first particle size range, the second particle size range and the third particle size range; When the percentage of particles in the third particle size range is less than 98%, the controller (700) controls the electric cylinder (503) to reduce the gap between the shaft sleeve (502) and the flow equalizing plate (504); when the percentage of particles in the third particle size range is greater than 99%, the controller (700) controls the electric cylinder (503) to increase the gap between the shaft sleeve (502) and the flow equalizing plate (504); and finally, through adjustment, the percentage of particles in the third particle size range among the drug particles falling into the separation cylinder (102) is stabilized at 98% to 99%; After the above process adjustment is completed, the controller (700) controls the driving motor (601) to drive the valve (602) to close; S8. After the screening is completed, the drug particles discharged from the reflux chamber (209) are collected as drug particles in the first particle size range, the drug particles in a plurality of the material distribution chambers (104) are collected as drug particles in the second particle size range, and the drug particles in the separation cylinder (102) are collected as drug particles in the third particle size range. The operator obtains the final drug particles from the corresponding ranges according to different required ranges.

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