Oral care compositions comprising opacifiers

Abstract

An oral care composition comprising boron nitride as an opacifier in place of titanium dioxide and / or zinc oxide. A toothpaste and / or dentifrice composition comprising boron nitride as an opacifier. Oral care compositions, such as toothpaste and / or dentifrice compositions, comprising boron nitride as the sole opacifier. An oral care composition having a suitable opacity but not containing titanium dioxide.

Description

Technical Field

[0001] The present invention relates to oral care compositions comprising a sunscreen. The present invention also relates to opaque oral care compositions such as toothpaste and / or dentifrice compositions that do not contain titanium dioxide, zinc oxide and / or combinations thereof. The present invention also relates to oral care compositions such as toothpaste and / or dentifrice compositions that contain boron nitride as a sunscreen. The present invention also relates to oral care compositions such as toothpaste and / or dentifrice compositions that contain boron nitride as the sole sunscreen. Background Art

[0002] Typically, toothpaste compositions are formulated into a single-phase aqueous matrix or a single-phase non-aqueous matrix. In many cases, ingredients are added to toothpaste compositions, which can cause the toothpaste to have an unattractive cloudy appearance, neither completely translucent nor completely opaque. Therefore, traditional sunscreens such as titanium dioxide, which are usually insoluble particles, are added to the formulation to make the paste composition have a consistent opaque and / or white appearance. However, many consumers believe that some traditional sunscreens such as titanium dioxide may be harmful to health due to their particle size or are considered unsafe due to other biological reasons. Titanium dioxide has been banned in all foods in the European market, and several regulations are paying attention to banning titanium dioxide in personal and health care products.

[0003] Therefore, there is a need for a toothpaste composition having suitable opacity without the incorporation of traditional opacifiers such as titanium dioxide.There is also a need for new opacifiers for use in oral care compositions.

[0004] In addition, oral care compositions include a variety of components that can interact with each other. Many insoluble compounds that can be used as sunscreens can interact with other components of the oral care composition, such as fluoride and stannous. Therefore, there is a need for sunscreens that do not react with other components of the oral care composition or are inert in their reactivity. Summary of the invention

[0005] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) an oral care active agent.

[0006] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) fluoride.

[0007] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) tin.

[0008] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) an abrasive.

[0009] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) a dicarboxylic acid.

[0010] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) a polyphosphate.

[0011] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) hops.

[0012] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) a peroxide.

[0013] Disclosed herein is a toothpaste composition, such as an opaque toothpaste composition, comprising: (a) boron nitride; and (b) other opacifiers. DETAILED DESCRIPTION

[0014] The present invention relates to oral care compositions containing boron nitride having suitable opacity. Many traditional sunscreens are considered to have health risks, therefore, the present application relates to the use of boron nitride as a sunscreen to replace traditional sunscreens such as titanium dioxide and / or zinc oxide. Unexpectedly, it has been found that toothpastes containing boron nitride provide suitable opacity while maintaining acceptable levels of fluoride and stannous ions.

[0015] definition

[0016] As used herein, the term "oral care composition" includes products that are not intended to be swallowed for the purpose of systemic administration of a particular therapeutic agent during ordinary use, but are retained in the oral cavity for a sufficient period of time to contact tooth surfaces or oral tissues. Examples of oral care compositions include dentifrices, tooth gels, subgingival gels, mouthwashes, mousses, foams, mouth sprays, lozenges, chewable tablets, chewing gums, tooth whitening strips, dental floss and dental floss coatings, breath freshening dissolvable strips, or denture care or adhesive products. Oral care compositions may also be incorporated into strips or films for direct application or attachment to oral surfaces. Addition of "unit doses" and / or fibrous compositions

[0017] Unless otherwise indicated, as used herein, term "dentifrices composition" includes tooth or subgingival paste, gel or liquid preparation.Dentifrices composition can be a single phase composition, or can be a combination of two or more independent dentifrice compositions.Dentifrices composition can be in any desired form, such as deep stripes, shallow stripes, multilayer, gel around the paste or their arbitrary combination.In the dentifrice comprising two or more independent dentifrice compositions, each kind of dentifrice composition can be contained in physically independent dispenser compartments, and is distributed side by side.

[0018] As used herein, the term "substantially free" means that no more than 0.05%, preferably no more than 0.01% and more preferably no more than 0.001% of a specified material is present in the composition, based on the total weight of such composition.

[0019] As used herein, the term "substantially free" means that the indicated material is not intentionally added to the composition, or preferably is not present at an analytically detectable level. This is meant to include compositions in which the indicated material is present only as an impurity in one of the other intentionally added materials.

[0020] Although compositions and methods are described herein as "comprising" various components or steps, unless otherwise indicated, the compositions and methods may also "consist essentially of" or "consist of" the various components or steps. - Should we define consisting essentially of?

[0021] Unless otherwise indicated, all measurements mentioned herein were conducted at about 23°C (ie, room temperature).

[0022] The oral care composition as described herein comprises (1) boron nitride and / or beta-calcium pyrophosphate and (2) an oral care active agent such as fluoride, tin, zinc, polyphosphate, dicarboxylic acid and / or other ingredients disclosed herein. In addition, the oral care composition may include other optional ingredients, as described below. The following section headings are provided only for convenience. In some cases, a compound may fall into one or more sections. For example, stannous fluoride may be a tin compound and / or a fluoride compound.

[0023] Boron Nitride

[0024] The present invention relates to oral care compositions such as toothpaste and / or dentifrice compositions comprising boron nitride as an opacifier. Typically, toothpaste compositions are formulated as a single-phase aqueous matrix or a single-phase non-aqueous matrix. In many cases, ingredients are added to toothpaste compositions, which can result in a toothpaste having an unattractive cloudy appearance, neither completely translucent nor completely opaque. Therefore, traditional opacifiers such as titanium dioxide, which are typically insoluble particles, are added to the formulation to give the paste composition a consistent opaque and / or white appearance. However, many consumers believe that certain traditional opacifiers such as titanium dioxide may be harmful to health due to their particle size.

[0025] Thus, the present invention relates to the use of boron nitride as a sunscreen. Boron nitride can be added to oral care compositions containing lower amounts of titanium dioxide and / or zinc oxide, or boron nitride can be used to completely replace titanium dioxide and / or zinc oxide. Boron nitride can also be mixed with other sunscreens such as calcium pyrophosphate, bismuth oxychloride, mica, EGDS, sericite, or combinations thereof.

[0026] Boron nitride can be a compound containing equal amounts of boron and nitrogen atoms in various crystalline forms, which are well known to those of ordinary skill in the art. Boron nitride can be amorphous (a-boron nitride), hexagonal (h-boron nitride), cubic (c-boron nitride), wurtzite (w-boron nitride), and / or combinations thereof.

[0027] Boron nitride may also have metal ions such as sodium, potassium, calcium, tin, zinc, and / or combinations thereof intercalated between the boron nitride sheets.

[0028] The boron nitride can have an average particle size of from about 0.5 microns to about 100 microns, from about 1 micron to about 50 microns, or from about 2 microns or from about 30 microns.

[0029] The oral care composition may comprise from about 0.001 to about 10%, from about 0.01% to about 5%, or from about 0.1% to about 2%, by weight of the oral care composition, of boron nitride.

[0030] The oral care composition and / or toothpaste composition comprising boron nitride can have an opacity that is about the same as or greater than that of an oral care composition and / or toothpaste composition comprising titanium dioxide and / or zinc oxide. The opaque toothpaste comprising boron nitride can have a whiteness value (*L) of about 40 to 100, about 60 to 100, or about 75 to 100.

[0031] Additionally, boron nitride can be inert and / or have minimal interaction with other oral care actives (such as fluoride, tin, zinc, polyphosphates, dicarboxylic acids, peroxides, amino acids, or combinations thereof) and / or abrasives.Each oral care active is described in more detail in the following sections.

[0032] Calcium pyrophosphate

[0033] The present invention relates to oral care compositions such as toothpaste and / or dentifrice compositions which may contain calcium pyrophosphate as an opacifying agent.

[0034] The present invention relates to oral care compositions such as toothpaste and / or dentifrice compositions comprising boron nitride as an opacifier. Typically, toothpaste compositions are formulated as a single-phase aqueous matrix or a single-phase non-aqueous matrix. In many cases, ingredients are added to toothpaste compositions, which can result in a toothpaste having an unattractive cloudy appearance, neither completely translucent nor completely opaque. Therefore, traditional opacifiers such as titanium dioxide, which are typically insoluble particles, are added to the formulation to give the paste composition a consistent opaque and / or white appearance. However, many consumers believe that certain traditional opacifiers such as titanium dioxide may be harmful to health due to their particle size.

[0035] Thus, the present invention may relate to the use of calcium pyrophosphate as a sunscreen. Calcium pyrophosphate may be added to oral care compositions containing lower amounts of titanium dioxide and / or zinc oxide, or boron nitride may be used to completely replace titanium dioxide and / or zinc oxide. Calcium pyrophosphate may also be mixed with other sunscreens such as boron nitride, bismuth oxychloride, mica, EGDS, sericite, or combinations thereof.

[0036] Although not wishing to be bound by theory, it is believed that calcium pyrophosphate from a particular source is sufficiently compatible with fluoride and / or tin for use in oral care compositions comprising fluoride and / or tin. Calcium pyrophosphate has at least three polymorphic phases: α, β and γ. Surprisingly, it has been found that calcium pyrophosphate with a higher proportion of β phase is more compatible with fluoride and / or tin while providing a suitable whiteness value. An opaque toothpaste comprising β calcium pyrophosphate can have a whiteness value (*L) of about 40 to 100, about 60 to 100, or about 75 to 100.

[0037] The oral care composition may comprise from about 0.001 to about 10%, from about 0.01% to about 5%, or from about 0.1% to about 2% beta calcium pyrophosphate, by weight of the oral care composition.

[0038] The calcium pyrophosphate can include at least about 30%, at least about 40%, at least about 50%, and / or at least about 75% of the calcium pyrophosphate in the beta phase, based on the weight of the calcium pyrophosphate.

[0039] Oral Care Actives

[0040] The oral care composition may combine boron nitride and / or beta-calcium pyrophosphate with one or more oral care actives including, but not limited to, fluoride, metals, tin, zinc, dicarboxylic acids, peroxides, amino acids, and / or hops, as further described herein.

[0041] Fluoride

[0042] The oral care composition may contain fluoride, which may be provided by a fluoride ion source. The fluoride ion source may include one or more fluoride-containing compounds such as stannous fluoride, sodium fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, zinc fluoride, and / or mixtures thereof.

[0043] The fluoride ion source and the tin ion source can be the same compound, for example, stannous fluoride, which can generate tin ions and fluoride ions. In addition, the fluoride ion source and the tin ion source can be separate compounds, such as when the tin ion source is stannous chloride and the fluoride ion source is sodium monofluorophosphate or sodium fluoride.

[0044] The fluoride ion source and the zinc ion source can be the same compound, for example, zinc fluoride, which can generate zinc ions and fluoride ions. In addition, the fluoride ion source and the zinc ion source can be separate compounds, such as when the zinc ion source is zinc phosphate and the fluoride ion source is stannous fluoride.

[0045] The fluoride ion source may be substantially free or free of stannous fluoride.Thus, the oral care composition may comprise sodium fluoride, potassium fluoride, amine fluoride, sodium monofluorophosphate, zinc fluoride and / or mixtures thereof.

[0046] The oral care composition may include a fluoride ion source capable of providing from about 50 ppm to about 5000 ppm and preferably from about 500 ppm to about 3000 ppm of free fluoride ions. To deliver the desired amount of fluoride ions, the fluoride ion source may be present in the oral care composition in an amount of from about 0.0025% to about 5%, from about 0.01% to about 5%, from about 0.2% to about 1%, from about 0.5% to about 1.5%, or from about 0.3% to about 0.6% by weight of the oral care composition. Alternatively, the oral care composition may include less than 0.1%, less than 0.01%, substantially free, essentially free, or free of a fluoride ion source.

[0047] Metal

[0048] Oral care compositions as described herein may include metals, which may be provided by a metal ion source comprising one or more metal ions. As described herein, the metal ion source may include a tin ion source and / or a zinc ion source or in addition to a tin ion source and / or a zinc ion source. Suitable metal ion sources include compounds with metal ions, such as but not limited to Sn, Zn, Cu, Mn, Mg, Sr, Ti, Fe, Mo, B, Ba, Ce, Al, In and / or mixtures thereof. The metal ion source may be any compound with a suitable metal and any associated ligand and / or anion.

[0049] Suitable ligands and / or anions that may be paired with a metal ion source include, but are not limited to, acetate, ammonium sulfate, benzoate, bromide, borate, carbonate, chloride, citrate, gluconate, glycerophosphate, hydroxide, iodide, oxalate, oxide, propionate, D-lactate, DL-lactate, orthophosphate, pyrophosphate, sulfate, nitrate, tartrate, and / or mixtures thereof.

[0050] The oral care composition may comprise from about 0.01% to about 10%, from about 1% to about 5%, or from about 0.5% to about 15% of a metal and / or metal ion source.

[0051] tin

[0052] Oral care compositions of the present invention may include tin, which may be provided by a tin ion source. The tin ion source may be any suitable compound, which may provide tin ions in the oral care compositions and / or deliver tin ions to the oral cavity when the oral care compositions are applied thereto. The tin ion source may include one or more tin-containing compounds, such as stannous fluoride, stannous chloride, stannous bromide, stannous iodide, stannous oxide, stannous oxalate, stannous sulfate, stannous sulfide, stannous fluoride, stannous chloride, stannous bromide, stannous iodide, stannous sulfide and / or mixtures thereof. The tin ion source may include stannous fluoride, stannous chloride and / or mixtures thereof. The tin ion source may also be a tin ion source that does not contain fluorine, such as stannous chloride.

[0053] The oral care composition may comprise from about 0.0025% to about 15%, from about 0.01% to about 10%, from about 0.2% to about 1%, from about 0.4% to about 1%, or from about 0.3% to about 0.6%, by weight of the oral care composition, of tin and / or a source of tin ions.

[0054] Zinc

[0055] The oral care composition may include zinc, which may be provided by a zinc ion source. The zinc ion source may include one or more zinc-containing compounds, such as zinc fluoride, zinc lactate, zinc oxide, zinc phosphate, zinc chloride, zinc acetate, zinc hexafluorozirconate, zinc sulfate, zinc tartrate, zinc gluconate, zinc citrate, zinc malate, zinc glycinate, zinc pyrophosphate, zinc metaphosphate, zinc oxalate and / or zinc carbonate. The zinc ion source may be a fluoride-free zinc ion source, such as zinc phosphate, zinc oxide and / or zinc citrate.

[0056] Zinc and / or a source of zinc ions may be present in the total oral care composition in an amount from about 0.01% to about 10%, from about 0.2% to about 1%, from about 0.5% to about 1.5%, or from about 0.3% to about 0.6% by weight of the dentifrice composition. Alternatively, the oral care composition may be substantially free, essentially free, or free of zinc.

[0057] Dicarboxylic Acids

[0058] The oral care composition and / or the multidentate ligand may comprise a dicarboxylic acid. The dicarboxylic acid includes compounds having two carboxylic acid functional groups. The dicarboxylic acid may include a compound defined by formula I or a salt thereof.

[0059]

[0060] R can be empty, alkyl, alkenyl, allyl, phenyl, benzyl, aliphatic, aromatic, polyethylene glycol, polymer, O, N, P, and / or combinations thereof.

[0061] Dicarboxylic acid can comprise oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, undecane dioic acid, dodecanedioic acid, tridecanedioic acid, hexadecanedioic acid, Japan wax acid, cork original acid, equisetic acid, malic acid, maleic acid, tartaric acid, phthalic acid, methylmalonic acid, dimethylmalonic acid, hydroxymalonic acid, mesooxalic acid, dihydroxymalonic acid, fumaric acid, terephthalic acid, glutaric acid, their salt or their combination.Dicarboxylic acid can comprise the suitable salt of dicarboxylic acid, such as other metal salts of monoalkali metal oxalate, dialkali metal oxalate, monohydrogen oxalate monopotassium, dipotassium oxalate, monohydrogen oxalate monosodium, disodium oxalate, titanium oxalate and / or oxalate.Dicarboxylic acid can also comprise the hydrate of dicarboxylic acid and / or the hydrate of the salt of dicarboxylic acid.

[0062] The oral care composition may comprise from about 0.01% to about 10%, from about 0.1% to about 15%, from about 1% to about 5%, or from about 0.0001 to about 25%, by weight of the oral care composition, of a dicarboxylic acid.

[0063] Polyphosphate

[0064] Oral care compositions can include polyphosphates, which can be provided by a polyphosphate source. The polyphosphate source can include one or more polyphosphate molecules. Polyphosphates are a class of substances obtained by dehydrating and condensing orthophosphates to generate linear and cyclic polyphosphates of different chain lengths, such as phytic acid. Therefore, polyphosphate molecules are usually identified by the average number (n) of polyphosphate molecules, as described below. Although some cyclic derivatives may exist, it is generally believed that polyphosphates consist of two or more phosphate molecules arranged primarily in a linear configuration.

[0065] Preferred polyphosphates are those having an average of two or more phosphate groups so that surface adsorption at an effective concentration produces sufficient unbound phosphate functional groups, which enhances the anionic surface charge and the hydrophilic nature of the surface. Preferred in the present invention are linear polyphosphates having the formula: XO(XPO3) n X, wherein X is sodium, potassium, ammonium, or any other alkali metal cation, and n is, on average, from about 2 to about 21, from about 2 to about 14, or from about 2 to about 7. Alkaline earth metal cations, such as calcium, are not preferred because they tend to form insoluble fluoride salts from aqueous solutions containing fluoride ions and alkaline earth metal cations. Thus, the oral care compositions disclosed herein can be free of or substantially free of calcium pyrophosphate.

[0066] Some examples of suitable polyphosphate molecules include, for example, pyrophosphate (n=2), tripolyphosphate (n=3), tetrapolyphosphate (n=4), sodium polyphosphate (n=6), hexapolyphosphate (n=13), benzene polyphosphate (n=14), hexametaphosphate (n=21), also known as Glass H. Polyphosphates may include those polyphosphate compounds produced by FMC Corporation, ICL Performance Products, and / or Astaris.

[0067] The oral care composition may contain from about 0.01% to about 15%, from about 0.1% to about 10%, from about 0.5% to about 5%, from about 1% to about 20%, or about 10% or less of a polyphosphate source by weight of the oral care composition. Alternatively, the oral care composition may be substantially free, essentially free, or free of polyphosphate. The oral care composition may be substantially free, essentially free, or free of cyclic polyphosphates. The oral care composition may be substantially free, essentially free, or free of phytic acid, which may result in insoluble tin and / or zinc compounds.

[0068] Surfactants

[0069] The oral care composition may include one or more surfactants. Surfactants can be used to make the composition more cosmetically acceptable and / or acceptable to consumers. Surfactants can be detersive materials that impart detersive and foaming properties to the composition. Suitable surfactants include anionic surfactants, cationic surfactants, nonionic surfactants, zwitterionic surfactants, amphoteric surfactants and / or betaine surfactants. Other suitable surfactants include sodium lauryl sulfate, sodium lauryl isethionate, sodium lauroyl methyl isethionate, sodium cocoyl glutamate, sodium dodecylbenzene sulfonate, alkali metal or ammonium salts of lauroyl sarcosine, myristoyl sarcosine, palmitoyl sarcosine, stearoyl sarcosine and oleoyl sarcosine, polyoxyethylene sorbitan monostearate, isostearate and laurate, sodium lauryl sulfoacetate, sodium, potassium and ethanolamine salts of N-lauroyl sarcosine, N-lauroyl, N-myristoyl or N-palmitoyl sarcosine, polyethylene oxide condensates of alkylphenols, cocoamidopropyl betaine, lauroylamidopropyl betaine, palmityl betaine, sodium cocoyl glutamate, etc. Sodium lauryl sulfate is a preferred surfactant. The oral care composition may include one or more surfactants, each present at a level of from about 0.01% to about 15%, from about 0.3% to about 10%, or from about 0.3% to about 2.5%, by weight of the oral care composition.

[0070] Thickener

[0071] Oral care compositions may include one or more thickeners. Thickeners can be used in oral care compositions to provide a gel-like structure to stabilize toothpaste to prevent phase separation. Suitable thickeners include polysaccharides, polymers and / or silica thickeners. Some non-limiting examples of polysaccharides include starch; starch glycerol; gums such as karaya gum (gum karaya), tragacanth, gum arabic, gum ghatti, gum arabic, xanthan gum, guar gum and cellulose gum; magnesium aluminum silicate (colloidal magnesium aluminum silicate); carrageenan; sodium alginate; agar; pectin; gelatin; cellulose compounds such as cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, hydroxymethyl carboxypropyl cellulose, methyl cellulose, ethyl cellulose and sulfated cellulose; natural and synthetic clays, such as hectorite clay; and mixtures thereof.

[0072] Thickeners may include polysaccharides. Suitable polysaccharides for use herein include carrageenan, gellan gum, locust bean gum, xanthan gum, carbomer, poloxamer, modified cellulose, and mixtures thereof. Carrageenan is a polysaccharide derived from seaweed. There are several types of carrageenan, which can be distinguished by their seaweed sources and / or by their degree of sulfation and position. Thickeners may include kappa-carrageenan, modified kappa-carrageenan, iota-carrageenan, modified iota-carrageenan, lambda-carrageenan, and mixtures thereof. Suitable carrageenans for use herein include those commercially available from FMC Company under the serial name "Viscarin", including but not limited to Viscarin TP 329, Viscarin TP388, and Viscarin TP 389.

[0073] The thickener may comprise one or more polymers. The polymer may be polyethylene glycol (PEG), polyvinyl pyrrolidone (PVP), polyacrylic acid, a polymer derived from at least one acrylic acid monomer, a copolymer of maleic anhydride and methyl vinyl ether, a cross-linked polyacrylic acid polymer, having various weight percentages of the oral care composition and various ranges of average molecular weight ranges. The polymer may include a polyacrylate cross-linked polymer, such as polyacrylate cross-linked polymer-6. Suitable sources of polyacrylate cross-linked polymer-6 may include Sepimax Zen, commercially available from Seppic TM .

[0074] The thickener may include an inorganic thickener. Some non-limiting examples of suitable inorganic thickeners include colloidal magnesium aluminum silicate, silica thickeners. Non-limiting examples of useful silica thickeners include, for example, amorphous precipitated silica, such as 165 silica. Other non-limiting silica thickeners include 153, 163 and 167 and 177 and 265 silica products (both available from Evonik Corporation), and Fumed silica.

[0075] The oral care composition may comprise from 0.01% to about 15%, from 0.1% to about 10%, from about 0.2% to about 5%, or from about 0.5% to about 2% of one or more thickening agents.

[0076] Abrasive

[0077] The oral care composition of the present invention may include an abrasive. Abrasives may be added to oral care formulations to help remove surface stains on teeth. Abrasives may include calcium abrasives and / or silica abrasives.

[0078] The calcium abrasive can be any suitable abrasive compound that can provide calcium ions in the oral care composition and / or deliver calcium ions to the oral cavity when the oral care composition is applied to the oral cavity. The oral care composition can contain about 5% to about 70%, about 10% to about 60%, about 20% to about 50%, about 25% to about 40%, or about 1% to about 50% of a calcium abrasive. The calcium abrasive can include one or more calcium abrasive compounds, such as calcium carbonate, precipitated calcium carbonate (PCC), ground calcium carbonate (GCC), chalk, dicalcium phosphate, calcium pyrophosphate, and / or mixtures thereof.

[0079] The oral care composition may also include a silica abrasive, such as colloidal silica (either by itself or in any structure), precipitated silica, amorphous precipitated silica (either by itself or in any structure), hydrated silica, and / or combinations thereof. The oral care composition may include from about 5% to about 70%, from about 10% to about 60%, from about 10% to about 50%, from about 20% to about 50%, from about 25% to about 40%, or from about 1% to about 50% of a silica abrasive.

[0080] Abrasives may also include bentonite, perlite, titanium dioxide, alumina, hydrated alumina, calcined alumina, aluminum silicate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, insoluble magnesium carbonate, zirconium silicate, particulate thermosetting resins, and other suitable abrasive materials. The oral care composition may contain from about 5% to about 70%, from about 10% to about 60%, from about 10% to about 50%, from about 20% to about 50%, from about 25% to about 40%, or from about 1% to about 50% of another abrasive.

[0081] Amino Acids

[0082] The oral care composition may comprise an amino acid. As described herein, the amino acid may include one or more amino acids, peptides and / or polypeptides.

[0083] As shown in Formula II, amino acid is an organic compound containing an amine functional group, a carboxyl functional group and a side chain (R in Formula II) unique to each amino acid. Suitable amino acids include, for example, amino acids with positive or negative side chains, amino acids with acidic or basic side chains, amino acids with polar uncharged side chains, amino acids with hydrophobic side chains and / or combinations thereof. Suitable amino acids also include, for example, arginine, histidine, lysine, aspartic acid, glutamic acid, serine, threonine, asparagine, glutamine, cysteine, selenocysteine, glycine, proline, alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, tryptophan, citrulline, ornithine, creatine, diaminobutyric acid, diaminopropionic acid, their salts and / or combinations thereof.

[0084] Suitable amino acids include compounds of formula II, naturally occurring or synthetically derived. Depending on the R group and the environment, the amino acid can be zwitterionic, neutral, positively charged or negatively charged. The charge of the amino acid and whether a particular functional group can interact with tin under specific pH conditions are well known to those of ordinary skill in the art.

[0085]

[0086] Suitable amino acids include one or more basic amino acids, one or more acidic amino acids, one or more neutral amino acids, or a combination thereof.

[0087] The oral care composition may comprise from about 0.01% to about 20%, from about 0.1% to about 10%, from about 0.5% to about 6%, or from about 1% to about 10%, by weight of the oral care composition, of an amino acid.

[0088] As used herein, the term "neutral amino acid" includes not only naturally occurring neutral amino acids such as alanine, asparagine, cysteine, glutamine, glycine, isoleucine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, but also other amino acids with isoelectric points in the range of pH 5.0 to 7.0. Neutral amino acids may also be at least partially water-soluble and provide a pH of about 7 or less in an aqueous solution of 1 g of the neutral amino acid in 1000 mL of distilled water at 25°C.

[0089] Therefore, suitable neutral amino acids may also include alanine, aminobutyric acid, asparagine, cysteine, cystine, glutamine, glycine, hydroxyproline, isoleucine, leucine, methionine, phenylalanine, proline, serine, taurine, threonine, tryptophan, tyrosine, valine, their salts or mixtures thereof. Preferably, the neutral amino acids used in the compositions of the present invention may include asparagine, glutamine, glycine, their salts and / or mixtures thereof.

[0090] Whitening Agents

[0091] The oral care composition may contain from about 0.1% to about 10%, from about 0.2% to about 5%, from about 1% to about 5%, or from about 1% to about 15% of a whitening agent by weight of the oral care composition. The whitening agent may be a compound suitable for whitening at least one tooth in the oral cavity. The whitening agent may include peroxides, metal chlorites, perborates, percarbonates, peroxyacids, persulfates, dicarboxylic acids, and combinations thereof. Suitable peroxides include solid peroxides, hydrogen peroxide, urea peroxide, calcium peroxide, benzoyl peroxide, sodium peroxide, barium peroxide, inorganic peroxides, hydroperoxides, organic peroxides, and mixtures thereof. Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite. Other suitable whitening agents include sodium persulfate, potassium persulfate, Peroxydone complex (polyvinyl pyrrolidone and hydrogen peroxide), 6-phthalimidoperoxycaproic acid, phthalimidoperoxycaproic acid, or mixtures thereof.

[0092] Wetting agent

[0093] Oral care composition can comprise one or more wetting agents, have low content of wetting agent, do not contain wetting agent, do not contain wetting agent substantially, and / or do not contain wetting agent in fact.Wetting agent is used to increase the consistency or " mouthfeel " of oral care composition or dentifrice and prevent dentifrice from drying out.Suitable wetting agent comprises polyethylene glycol (having multiple different molecular weight), propylene glycol, glycerine (glycerin, glycerol), erythritol, xylitol, sorbitol, mannitol, butylene glycol, lactitol, hydrogenated starch hydrolysate and / or their mixture.Oral care composition can comprise one or more wetting agents, and the content of each wetting agent is by the weight of this oral care composition 0% to about 70%, about 5% to about 50%, about 10% to about 60% or about 20% to about 80%.

[0094] water

[0095] The oral care compositions of the present invention may be an anhydrous dentifrice composition, a low water formulation, or a high water formulation. In general, the oral care composition may comprise 0% to about 99%, about 20% or more, about 30% or more, about 50% or more, up to about 45%, or up to about 75% water by weight of the composition. Preferably, the water is USP water.

[0096] In a high water dentifrice formulation, the dentifrice composition comprises from about 45% to about 75% water by weight of the composition. The high water dentifrice composition may comprise from about 45% to about 65%, from about 45% to about 55%, or from about 46% to about 54% water by weight of the composition. Water may be added to the high water dentifrice formulation and / or water may enter the composition as a result of the inclusion of other ingredients.

[0097] In a low-water dentifrice formulation, the dentifrice composition comprises from about 10% to about 45% water by weight of the composition. The low-water dentifrice composition may comprise from about 10% to about 35%, from about 15% to about 25%, or from about 20% to about 25% water by weight of the composition. Water may be added to the low-water dentifrice formulation and / or water may enter the composition as a result of the inclusion of other ingredients.

[0098] In an anhydrous dentifrice formulation, the dentifrice composition comprises less than about 10% water by weight of the composition. An anhydrous dentifrice composition comprises less than about 5%, less than about 1%, or 0% water by weight of the composition. Water may be added to the anhydrous formulation and / or may enter the dentifrice composition as a result of the inclusion of other ingredients.

[0099] Dentifrice compositions may also contain other orally acceptable carrier materials such as alcohols, humectants, polymers, surfactants, and acceptance-enhancing agents (such as flavorings, sweeteners, coloring agents, and / or cooling agents).

[0100] The oral care composition may also be a mouthwash formulation.The mouthwash formulation may comprise from about 75% to about 99%, from about 75% to about 95%, or from about 80% to about 95% water.

[0101] Hops

[0102] The oral care composition of the present invention may include hops. Hops may include at least one hop compound of formula III and / or formula VI. The compound of formula III and / or formula VI may be provided by any suitable source, such as an extract from Humulus lupulus or hops, hops itself, its synthetic derivative compounds and / or their salts, prodrugs or other analogs. Hops extract may include one or more hop alpha acids, one or more hop iso-alpha acids, one or more hop beta acids, one or more hop oils, one or more flavonoids, one or more solvents and / or water. Suitable hop alpha acids (generally represented by formula III) may include humulones (formula IV), polyhumulones, class humulones, rear humulones, front humulones and / or mixtures thereof. Suitable hop iso-alpha acids may include cis-isohumulones and / or trans-isohumulones. Isomerization of humulones to trans-isohumulones may be represented by formula V.

[0103]

[0104] Suitable hop beta acids may include lupulones, lupulones, addululones and / or mixtures thereof. Suitable hop beta acids may include compounds described in Formula III, VII, VIII and / or IX.

[0105]

[0106]

[0107] Although hop alpha acids can exhibit some antibacterial activity, hop alpha acids also have a bitter taste. The bitter taste provided by hop alpha acids may be suitable for use in beer, but not in oral care compositions. In contrast, hop beta acids may be associated with higher antibacterial and / or anticaries activity, but the taste is less bitter. Therefore, hop extracts having a higher ratio of beta acids to alpha acids than is typically found in nature may be suitable for use in oral care compositions as antibacterial and / or anticaries agents.

[0108] Depending on the type of hops, the natural hop source can include about 2% to about 12% hop beta acids by weight of the hop source. Hop extracts used in other cases, such as in the brewing of beer, can include about 15% to about 35% hop beta acids by weight of the extract. Hop extracts required herein can include at least about 35%, at least about 40%, at least about 45%, about 35% to about 95%, about 40% to about 90%, or about 45% to about 99% hop beta acids. Hop beta acids can be in acidic form (that is, with a hydrogen atom connected to a hydroxyl functional group) or in salt form.

[0109] Suitable hop extracts are described in detail in U.S. Pat. No. 7,910,140, ​​which is incorporated herein by reference in its entirety. The desired hop beta acids may be non-hydrogenated, partially hydrogenated by a non-naturally occurring chemical reaction, or hydrogenated by a non-naturally occurring chemical reaction. Hop beta acids may be substantially free of or essentially free of hydrogenated hop beta acids and / or hop acids. Non-naturally occurring chemical reactions are chemical reactions performed with the aid of compounds not present in hops, such as chemical hydrogenation reactions performed at high temperatures and / or metal catalysts that wild hops would not normally experience.

[0110] Natural hop sources may contain about 2% to about 12% hop alpha acids by weight of the hop source. Hop extracts used in other situations, such as in the brewing of beer, may contain about 15% to about 35% hop alpha acids by weight of the extract. Hop extracts desired herein may contain less than about 10%, less than about 5%, less than about 1%, or less than about 0.5% hop alpha acids by weight of the extract.

[0111] Hop oils may contain terpene hydrocarbons such as myrcene, humulene, caryophyllene and / or mixtures thereof. Hop extracts desired herein may contain less than 5%, less than 2.5%, or less than 2% of one or more hop oils by weight of the extract.

[0112] The flavonoids present in the hop extract may include xanthohumol, 8-prenylnaringenin, isoxanthohumol and / or mixtures thereof. The hop extract may be substantially free, essentially free, free or have less than 250 ppm, less than 150 ppm and / or less than 100 ppm of one or more flavonoids.

[0113] Hops acids have previously been added to oral care compositions as described in U.S. Pat. No. 5,370,863. However, the oral care compositions taught in U.S. Pat. No. 5,370,863 contain only up to 0.01% by weight of the oral care composition. Although not wishing to be bound by theory, it is believed that U.S. Pat. No. 5,370,863 can only incorporate small amounts of hop acids because hop alpha acids have a bitter taste. Hops extracts with low levels of hop alpha acids do not have this problem.

[0114] The hops compounds may be combined with or without an extract of another plant, such as a Magnolia species. The hops compounds may be combined with or without triclosan.

[0115] The oral care composition may include about 0.01% to about 10%, greater than 0.01% to about 10%, about 0.05%, to about 10%, about 0.1% to about 10%, about 0.2% to about 10%, about 0.2% to about 10%, about 0.2% to about 5%, about 0.25% to about 2%, about 0.05% to about 2%, or greater than 0.25% to about 2% of hops, such as hop beta acids, as described herein. Hops, such as hop beta acids, may be provided by suitable hop extracts, the hop plant itself, or synthetically derived compounds. Hops, such as hop beta acids, may be provided as neutral, acidic compounds, and / or as salts with suitable counterions such as sodium, potassium, ammonia, or any other suitable counterions.

[0116] Hops can be provided by a hop extract, such as an extract from hops having at least 35% hop beta acids by weight of the extract and less than 1% hop alpha acids by weight of the hop extract. The oral care composition can include 0.01% to about 10%, greater than 0.01% to about 10%, about 0.05%, to about 10%, about 0.1% to about 10%, about 0.2% to about 10%, about 0.2% to about 10%, about 0.2% to about 5%, about 0.25% to about 2%, about 0.05% to about 2%, or greater than 0.25% to about 2% of a hop extract, as described herein.

[0117] Other Ingredients

[0118] The oral care composition may contain a variety of other ingredients, such as flavoring agents, sweetening agents, coloring agents, preservatives, buffering agents, or other ingredients suitable for use in oral care compositions, as described below.

[0119] Flavoring agents can also be added to the oral care composition. Suitable flavoring agents include wintergreen oil, peppermint oil, spearmint oil, clove bud oil, menthol, p-propenylanisole, methyl salicylate, eucalyptol, cinnamon, 1-menthyl acetate, sage, eugenol, parsley oil, hydroxyphenyl butanone, α-ionone, sweet oregano, lemon, orange, propenyl ethyl guaiacol, cassia bark, vanillin, ethyl vanillin, heliotropin, 4-cis-heptenal, diacetyl, methyl p-tert-butylphenyl acetate, and mixtures thereof. Coolants can also be part of the flavoring system. Preferred coolants in the compositions of the present invention are p-menthanecarbamoyl agents, such as N-ethyl-p-menthane-3-carboxamide (commercially known as "WS-3") or N-(ethoxycarbonylmethyl)-3-p-menthanecarboxamide (commercially known as "WS-5") and mixtures thereof. Flavor systems are typically used in the composition at levels of from about 0.001% to about 5% by weight of the oral care composition.These flavoring agents typically comprise mixtures of aldehydes, ketones, esters, phenols, acids, and aliphatic, aromatic and other alcohols.

[0120] Sweeteners can be added to the oral care composition to impart a pleasant taste to the product. Suitable sweeteners include saccharin (e.g., sodium saccharin, potassium saccharin, or calcium saccharin), cyclamate (e.g., sodium, potassium, or calcium salts), acesulfame-K, afritosin, neohesperidin dihydrochalcone, aminated glycyrrhizin, dextrose, levulose, sucrose, mannose, sucralose, stevioside, and glucose.

[0121] Colorants are added to improve the aesthetic appearance of the product. Suitable colorants include, but are not limited to, those approved by the appropriate regulatory agencies such as the FDA and those listed in the European Food and Drug Directive, and include pigments such as TiO2, and colors such as FD&C and D&C dyes.

[0122] Preservatives may also be added to the oral care composition to prevent bacterial growth. Suitable preservatives approved for use in oral compositions, such as methylparaben, propylparaben, benzoic acid, and sodium benzoate, may be added in safe and effective amounts.

[0123] Titanium dioxide and / or zinc oxide may also be added to the compositions of the present invention. Titanium dioxide is a white powder that can add opacity to the composition. Alternatively, the oral care composition may be substantially free, essentially free and / or free of titanium dioxide and / or zinc oxide.

[0124] Other ingredients may be used in the oral care composition, such as desensitizing agents, healing agents, other anticaries agents, chelating / sequestering agents, vitamins, proteins, other antiplaque / anticalculus agents, sunscreens, antibiotics, antienzymes, enzymes, pH control agents, oxidants, antioxidants, and the like.

[0125] Example

[0126] The following examples further describe and demonstrate embodiments within the scope of the present invention. These examples are provided for illustrative purposes only and should not be construed as limitations of the present invention, as many variations are possible without departing from the spirit and scope of the present invention. Unless otherwise indicated, all exemplified amounts are concentrations by weight of the total composition, i.e., wt / wt percentages.

[0127] Opaque toothpaste composition

[0128] The control toothpaste and Examples 1-17 were prepared by mixing a toothpaste base (see Table ID for identification of toothpaste base) with one or more potential sunscreens, silicon dioxide, and flavoring agents. The control toothpaste did not contain any sunscreen.

[0129] Whiteness

[0130] The whiteness of the toothpaste compositions described in Tables 1 to 2 (control toothpaste and Examples 1-17) was determined using the CIE color model. The L*a*b* color readings of these compositions were evaluated using a handheld (portable) Smart Probe 400 colorimeter (IMS Inc.). A portable colorimeter is a color measurement instrument used for psychophysical analysis, which measures human eye-brain perception. The colorimetric data is read directly and provided as tristimulus values ​​- X, Y, Z. The Lab values ​​are calculated based on the tristimulus values.

[0131] The CIE L*a*b* color model (Lab) method is used to quantify toothpaste whiteness. The lightness (whiteness) component (L*) value can range from 0-100. Typically, toothpastes containing TiO2 have L* values ​​close to 90. Desirable compositions disclosed herein include compositions with L* values ​​of about 40 to 100, about 60 to 100, about 75 to 100, at least about 60, or at least about 75 that are white / opaque enough for consumer acceptance.

[0132] Fluoride Compatibility

[0133] Fluoride compatibility was determined by first preparing stannous fluoride and sodium gluconate stock solutions. 0.34 g of stannous fluoride, 0.48 g of sodium gluconate, and 74.3 g of water were mixed in a polypropylene bottle. The mixture was stirred at room temperature until all solids were dissolved. The target fluoride concentration was 1100 μg / g F-.

[0134] Next, prepare a 0.2N EDTA / 0.2N THAM buffer solution by weighing 74.4 g of disodium EDTA into a 1000 mL beaker, adding 24.2 g of THAM (2-amino-2-(hydroxymethyl)-1,3-propanediol) and approximately 800 mL of water. Stir the mixture until all solids are dissolved. Once the solution has equilibrated to room temperature, adjust the pH to 7.95-8.05 using 50% w / w NaOH, quantitatively transfer to a 1000 mL volumetric flask, dilute and mix thoroughly.

[0135] Fluoride working calibration standards were prepared from a 1000 ppm F-standard stock solution by diluting with EDTA / THAM buffer to target concentrations of 10, 50 and 100 μg / g F.

[0136] Prepare the test composition by weighing 3.49-3.51 g of the test composition into a sample cup equipped with a lid. Add 14.95-15.05 g of the stannous fluoride / sodium gluconate stock solution to the cup and mix.

[0137] A standard composition was prepared by adding only 14.95-15.05 g of stannous fluoride / sodium gluconate to a sample cup with a lid.

[0138] The prepared test composition and the prepared standard composition were stored at 60°C for 2 hours while rotating. The composition was removed from the storage device and centrifuged at a speed of 25000 RCF for 15 minutes. The clear supernatant was identified after centrifugation. 1.48-1.52 g of the separated clear supernatant was mixed with 13.47-13.53 g of additional EDTA / THAM buffer solution. A pre-calibrated fluoride electrode was placed in the solution and the concentration of fluoride ions was read.

[0139] Fluoride compatibility was determined using Formula A below.

[0140]

[0141] Formula A. Fluoride Compatibility

[0142] Table 1A. Toothpaste composition

[0143]

[0144] 1 See Table 1D 2 [Insert information on beta calcium pyrophosphate]; 3 Hall EGDS(Ethylene glycol distearate)

[0145] Table 1B. Toothpaste composition

[0146]

[0147]

[0148] 1 See Table 1D

[0149] Table 1C. Toothpaste composition

[0150]

[0151] 1 See Table 1D; 2 BN02; 3 BN30 Table 1D. Toothpaste base

[0152]

[0153]

[0154] Table 2A. Whiteness of toothpaste compositions

[0155]

[0156] Table 2B. Fluoride Compatibility

[0157]

[0158] Several sunscreens were screened for whiteness in Table 2A: calcium pyrophosphate, beta-calcium pyrophosphate, EGDS, bismuth oxychloride, sericite, mica, boron nitride, and / or combinations thereof. Ineffective sunscreens were screened out using an initial target *L value of 75. Only boron nitride, calcium pyrophosphate, and bismuth oxychloride were identified as having whiteness values ​​high enough to effectively replace titanium dioxide and / or zinc oxide.

[0159] Calcium pyrophosphate (Example 1) has an *L of 74.3, but starting from a target fluoride amount of 1100 ppm, has low soluble fluoride numbers initially (702 ppm) and at 30 days (589 ppm). Therefore, calcium pyrophosphate (Example 1) is not compatible enough with fluoride to be used as an opacifier in a fluoride-containing toothpaste product.

[0160] The calcium pyrophosphate that is primarily in the β-phase (Example 2) has a slightly higher whiteness value of 75.7, but starting from a target fluoride level of 1100 ppm, has a much higher soluble fluoride number initially (814 ppm) and at 30 days (827 ppm). Therefore, the β-calcium pyrophosphate (Example 2) is sufficiently compatible with fluoride to be used as an opacifier in a fluoride-containing toothpaste product.

[0161] Bismuth oxychloride (Example 8 and Example 9) had whiteness values ​​(*L) of 75.8 and 80.9 and high levels of fluoride compatibility (97.9% and 100.8%).

[0162] Boron nitride (Examples 13-17) has a whiteness value (*L) ranging from 69.6 to 86.5. The whiteness value is 86.5 at 1% boron nitride (2 μm, Example 13). In addition, boron nitride is unexpectedly stable with fluorides, showing 94%-96% fluoride compatibility, depending on the average diameter of the boron nitride particles. Therefore, boron nitride unexpectedly provides suitable whiteness and fluoride compatibility, so that boron nitride can replace titanium dioxide and / or zinc oxide alone or in part as a sunscreen in toothpaste.

[0163] Unless expressly excluded or otherwise limited, each document cited herein, including any cross-referenced or related patent or patent application and any patent application or patent to which this application claims priority or the benefit of, is hereby incorporated by reference in its entirety. The citation of any document is not an admission that it is prior art with respect to any invention disclosed or claimed herein, nor is it an admission that it alone or in any combination with any other reference or references teaches, suggests or discloses any such invention. In addition, when any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall govern.

[0164] Although specific embodiments of the present invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications may be made without departing from the spirit and scope of the present invention. Therefore, it is intended that all such changes and modifications within the scope of the present invention be covered in the appended claims.

Claims

1. A toothpaste composition comprising: (a) Boron nitride; and (b) an oral care active, preferably wherein the oral care active comprises fluoride, tin, zinc, polyphosphate, dicarboxylic acid, peroxide, amino acid, hops, or a combination thereof.

2. The toothpaste composition of claim 1, wherein the toothpaste composition comprises from about 0.01% to about 5%, by weight of the toothpaste composition, of the boron nitride.

3. The toothpaste composition according to claim 1 or 2, wherein the toothpaste composition has a whiteness value (*L) of about 40 to 100, about 60 to 100, or about 75 to 100.

4. A toothpaste composition according to any one of claims 1 to 3, wherein the oral care active comprises a fluoride, preferably wherein the fluoride comprises sodium fluoride, stannous fluoride, sodium monofluorophosphate, an amine fluoride, or a combination thereof, or more preferably wherein the toothpaste composition has at least 800 ppm soluble fluoride after 30 days.

5. A toothpaste composition according to any one of claims 1 to 4, wherein the oral care active comprises tin, preferably wherein the tin comprises stannous fluoride, stannous chloride, stannous pyrophosphate, or a combination thereof, or more preferably wherein the toothpaste composition has at least 800 ppm soluble tin after 30 days.

6. The toothpaste composition according to any one of claims 1 to 5, wherein the zinc comprises zinc lactate, zinc citrate, zinc chloride, zinc phosphate, zinc oxide, or a combination thereof.

7. A toothpaste composition according to any one of claims 1 to 6, wherein the polyphosphate comprises a compound having the formula: XO(XPO3) n A linear polyphosphate of X, wherein X is sodium, potassium, ammonium, or any other alkali metal cation, and n averages from about 2 to about 21, preferably wherein the polyphosphate comprises pyrophosphate, tripolyphosphate, or hexametaphosphate.

8. The toothpaste composition according to any one of claims 1 to 7, wherein the dicarboxylic acid comprises oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, undecanedioic acid, dodecanedioic acid, tridecanedioic acid, hexadecanedioic acid, Japan wax acid, suberic acid, equisetic acid, malic acid, maleic acid, tartaric acid, phthalic acid, methylmalonic acid, dimethylmalonic acid, hydroxymalonic acid, meso-oxalic acid, dihydroxymalonic acid, fumaric acid, terephthalic acid, glutaric acid, their salts, or combinations thereof.

9. The toothpaste composition according to any one of claims 1 to 8, wherein the amino acid comprises arginine, histidine, lysine, aspartic acid, glutamic acid, serine, threonine, asparagine, glutamine, cysteine, selenocysteine, glycine, proline, alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, tryptophan, citrulline, ornithine, creatine, diaminobutyric acid, diaminopropionic acid, salts thereof, or combinations thereof, preferably wherein the amino acid comprises glycine.

10. A toothpaste composition according to any one of claims 1 to 9, wherein the toothpaste composition comprises an abrasive, preferably wherein the abrasive comprises a silica abrasive, a calcium abrasive, or a combination thereof, or more preferably wherein the calcium abrasive comprises calcium pyrophosphate, calcium carbonate, or a combination thereof.

11. The toothpaste composition according to any one of claims 1 to 10, wherein the boron nitride comprises amorphous boron nitride, hexagonal boron nitride, cubic boron nitride, wurtzite boron nitride, or a combination thereof.

12. A toothpaste composition according to any one of claims 1 to 11, wherein the boron nitride comprises boron nitride particles having an average particle size of about 1 micron to about 50 microns, preferably wherein the boron nitride comprises boron nitride particles having an average particle size of about 2 microns to about 30 microns.

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