Adeno-associated viral vectors for nucleic acid delivery across retina regions
Modified AAV vectors with enhanced capsid polypeptides improve nucleic acid delivery and expression in retinal cells, addressing inefficiencies of existing AAV vectors by achieving higher expression levels in retinal regions.
CN119213134APending Publication Date: 2024-12-27UNIV OF PITTSBURGH OF THE COMMONWEALTH SYST OF HIGHER EDUCATION
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Patent Information
- Application Number
- CN202380040952.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2022-03-30
- Filing Date
- 2023-03-30
- Publication Date
- 2024-12-27
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Abstract
This document relates to AAV vectors (e.g., AAV2 vectors). For example, provided are AAV vectors (e.g., AAV2 vectors) comprising an AAV capsid polypeptide comprising an amino acid sequence set forth in Table 1 (or a variant thereof) or an amino acid sequence of Formula A, such AAV capsid polypeptides, nucleic acid molecules encoding such vectors, nucleic acid molecules encoding such AAV capsid polypeptides, host cells containing and / or expressing such nucleic acid molecules, and methods for preparing such AAV capsid polypeptides. And methods and materials for making or using such vectors and / or AAV capsid polypeptides.
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