Buccal product, preparation method thereof and extraction method of sweet osmanthus extract

Abstract

The invention belongs to the technical field of buccal products, and relates to a buccal product which comprises an osmanthus fragrans extract, a nicotine source, a filling agent, a sweetening agent, an adhesive and a pH regulator. The invention also relates to an extraction method of the osmanthus fragrans extract and a preparation method of the buccal product. According to the technical scheme, the aroma effect of the buccal product can be improved, meanwhile, oxidation yellowing of the buccal product is delayed, and the storage time of the buccal product is prolonged.

Description

Technical Field

[0001] The present application relates to the technical field of oral products, and more specifically, to an oral product and a preparation method thereof, and an extraction method of osmanthus extract. Background Art

[0002] Nicotine source oral products are products applied to the oral cavity for the intake of nicotine sources. They have become an important research direction of tobacco substitutes at home and abroad.

[0003] The existing nicotine source oral products have a poor taste, are easily oxidized and yellowed during storage, and have a short storage period, thus affecting the user experience. Summary of the invention

[0004] The technical problem to be solved by the embodiments of the present application is that the existing nicotine source oral products have poor taste, are easily oxidized and yellowed during storage, and have a short storage period.

[0005] In order to solve the above technical problems, the present application provides an oral product, which adopts the following technical solution:

[0006] An oral product comprises an osmanthus extract, a nicotine source, a filler, a sweetener, a binder and a pH regulator.

[0007] Furthermore, the weight proportions of the components of the oral product are as follows:

[0008] 1 to 30 parts of osmanthus extract, 1 to 20 parts of nicotine source, 1 to 40 parts of filler, 1 to 20 parts of binder, 1 to 30 parts of sweetener and 1 to 20 parts of pH adjuster.

[0009] Further, the nicotine source is selected from at least one of nicotine benzoate, nicotine tartaric acid, nicotine resin, nicotine lactate, nicotine salicylate, nicotine malate, nicotine glycyrrhizinate, and nicotine resin; and / or,

[0010] The filler is selected from at least one of microcrystalline cellulose, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), pea fiber, and a-fiber; and / or,

[0011] The binder is selected from at least one of povidone K25, povidone K30 and sodium carboxymethyl cellulose; and / or,

[0012] The sweetener is selected from at least one of acesulfame potassium, sucralose, aspartame, xylitol, maltitol, erythritol, isomalt, mannitol and sorbitol; and / or,

[0013] The pH regulator is selected from at least one of sodium carbonate, sodium bicarbonate, magnesium oxide, magnesium oxide, potassium hydroxide, potassium carbonate and potassium bicarbonate.

[0014] In order to solve the above technical problems, the present application also provides a method for preparing an osmanthus extract, which adopts the following technical solution:

[0015] A method for extracting osmanthus extract, used for preparing the osmanthus extract in the oral preparation as described above, comprises the following steps:

[0016] Providing dried osmanthus flowers, and performing an enzyme extraction reaction on the dried osmanthus flowers to obtain a crude extract;

[0017] Extracting the supernatant of the crude extract, and performing a first drying treatment on the supernatant under normal pressure to obtain a crude extract;

[0018] Under vacuum conditions, subjecting the crude extract to a second drying treatment to obtain a refined extract;

[0019] The refined extract is subjected to vacuum drying treatment to obtain a powdered osmanthus extract.

[0020] Furthermore, the step of performing enzyme extraction reaction on the dried osmanthus flowers comprises the following steps:

[0021] placing the dried osmanthus flowers into distilled water;

[0022] The flavor enhancing enzyme is added to the distilled water to carry out enzyme extraction reaction to obtain the crude extract.

[0023] Further, the volume of the distilled water is 6 to 10 times the volume of the dried osmanthus flowers; and / or,

[0024] The reaction temperature of the enzyme extraction reaction is 40°C to 60°C; and / or,

[0025] The reaction time of the enzyme extraction reaction is 60 min to 100 min; and / or,

[0026] The flavor enhancing enzyme is selected from at least one of α-L-rhamnosidase, α-L-furanosidase, β-D-apiosidase, myrosinase, β-D-glucosidase, α-amyl glucosidase or cellulase.

[0027] Furthermore, the environment temperature of the first drying treatment is 50° C. to 70° C.; and / or,

[0028] The ambient pressure of the second drying process is 0.03Mpa to 0.05Mpa; and / or,

[0029] The ambient temperature of the second drying process is 50°C to 70°C; and / or,

[0030] The ambient pressure of the vacuum drying process is 4Pa to 6Pa; and / or,

[0031] The ambient temperature of the vacuum drying process is -60°C to -80°C; and / or,

[0032] The drying time of the vacuum drying process is 50 hours to 60 hours.

[0033] In order to solve the above technical problems, the present application also provides a method for preparing an oral product, which adopts the following technical solution:

[0034] A method for preparing an oral product, for preparing the oral product as described above, comprising the following steps:

[0035] Providing osmanthus extract, nicotine source, filler, sweetener, and pH regulator, and mixing them to obtain powder;

[0036] Providing a binder and an ethanol solution, stirring and mixing to obtain a paste;

[0037] The powder is mixed with the paste to obtain a primary product, and the primary product is extruded and granulated to obtain a granular material;

[0038] The granular material is packaged to obtain the oral product.

[0039] Furthermore, the step of extruding and granulating the primary product comprises the following steps:

[0040] Performing a first extrusion granulation on the primary product to obtain a secondary product;

[0041] After the secondary product is dried, a second extrusion granulation is performed to obtain the granular material.

[0042] Further, the concentration of the ethanol solution is 20% to 25%; and / or,

[0043] The mesh size of the first extrusion granulation is 40 to 60 meshes; and / or,

[0044] The drying temperature of the drying treatment is 50°C to 70°C; and / or,

[0045] The drying time of the drying treatment is 1h to 2h; and / or,

[0046] The mesh number of the second extrusion granulation screen is 40-60 meshes.

[0047] Compared with the prior art, the embodiments of the present application have the following beneficial effects:

[0048] The oral preparation provided in the present application adds osmanthus extract, and utilizes the natural aroma of the osmanthus extract to enhance the taste and aroma of the oral preparation, thereby improving the user experience; at the same time, the polysaccharides contained in the osmanthus extract have a certain antioxidant effect on the nicotine source, thereby delaying the oxidation and yellowing of the oral preparation and extending the storage period of the oral preparation. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] In order to more clearly illustrate the scheme of the present application, a brief introduction is given below to the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0050] Figure 1 is a flow chart of the extraction method of the osmanthus extract of the embodiment of the present application;

[0051] Figure 2 is a flow chart of a method for preparing an oral product according to an embodiment of the present application;

[0052] Figure 3 It is a comparative curve diagram of the effects of the sweet osmanthus extract extracted by the present application and vitamin C on the clearing effect of DPPH free radicals;

[0053] Figure 4 It is a comparison chart of the oral products of Example 1 of the present application and Comparative Example 1 after being placed for 28 hours. DETAILED DESCRIPTION

[0054] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by technicians in the technical field of this application; the terms used in the specification of the application herein are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" and any variations thereof in the specification and claims of this application and the above-mentioned drawings are intended to cover non-exclusive inclusions. The terms "first", "second", etc. in the specification and claims of this application or the above-mentioned drawings are used to distinguish different objects, not to describe a specific order.

[0055] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0056] Since nicotine contains two nitrogen heterocycles (pyridine and hydropyrrole), these two components are easily oxidized at room temperature and converted into other substances, which makes the color of nicotine darker and produces a bitter taste; therefore, when existing oral products containing nicotine sources are stored at room temperature, the oxidation of the nicotine source will cause the oral products to turn yellow and taste bitter, resulting in a poor user experience.

[0057] Based on the shortcomings of the oral preparations in the above-mentioned prior art, an embodiment of the present application provides an oral preparation, including osmanthus extract, a nicotine source, a filler, a sweetener, an adhesive and a pH regulator.

[0058] In this embodiment, the polysaccharide content of the osmanthus extract is 20%.

[0059] The embodiment of the present application adds osmanthus extract to the oral product, and utilizes the natural aroma of the osmanthus extract to enhance the taste and aroma of the oral product, thereby eliminating the bitter taste caused by the oxidation of the nicotine source and improving the user's taste; at the same time, the polysaccharides contained in the osmanthus extract have a certain antioxidant effect on the nicotine source, thereby delaying the oxidation of the nicotine source, delaying the oxidation and yellowing of the oral product, extending the storage period of the oral product, and enhancing the user's experience; in addition, the osmanthus extract used as an additive in the present application has a natural aroma and taste compared to conventional flavor additives, which can improve the user's comfort.

[0060] In some embodiments, the weight proportions of the components of the oral product are as follows:

[0061] 1 to 30 parts of osmanthus extract, 1 to 20 parts of nicotine source, 1 to 40 parts of filler, 1 to 20 parts of binder, 1 to 30 parts of sweetener and 1 to 20 parts of pH adjuster.

[0062] The embodiment of the present application adds a larger amount of osmanthus extract to inhibit the oxidation of the nicotine source and eliminate the bitter taste produced by the nicotine source.

[0063] In this embodiment, the osmanthus extract is a powder obtained by performing enzyme extraction reaction and several drying treatments on dried osmanthus flowers. The yield of polysaccharides, an effective ingredient of the osmanthus extract, in the powder prepared by the above method is high, and the content of polysaccharides in the osmanthus extract is greater than 20%.

[0064] In some embodiments, the nicotine source is selected from at least one of nicotine benzoate salt, nicotine tartaric acid salt, resin nicotine salt, nicotine lactate salt, nicotine salicylate salt, nicotine malate salt, nicotine glycyrrhizic acid salt, and resin nicotine salt.

[0065] In some embodiments, the filler is selected from at least one of microcrystalline cellulose, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), pea fiber, and a-fiber.

[0066] In some embodiments, the binder is selected from at least one of povidone K25, povidone K30, and sodium carboxymethyl cellulose.

[0067] In some embodiments, the sweetener is selected from at least one of acesulfame potassium, sucralose, aspartame, xylitol, maltitol, erythritol, isomalt, mannitol, and sorbitol.

[0068] In some embodiments, the pH adjuster is selected from at least one of sodium carbonate, sodium bicarbonate, magnesium oxide, magnesium oxide, potassium hydroxide, potassium carbonate, and potassium bicarbonate.

[0069] See also Figure 1 As shown, in order to provide osmanthus extract to the oral product, the embodiment of the present application also provides a method for extracting osmanthus extract, which specifically includes the following steps:

[0070] Step S10, providing dried osmanthus flowers, and performing enzyme extraction reaction on the dried osmanthus flowers to obtain a crude extract.

[0071] Step S20, extracting the supernatant of the crude extract, and performing a first drying treatment on the supernatant under normal pressure to obtain a crude extract.

[0072] Step S30, performing a second drying treatment on the crude extract under vacuum conditions to obtain a refined extract.

[0073] Step S40, vacuum drying the extract to obtain a powdered osmanthus extract.

[0074] The embodiment of the present application can extract the natural osmanthus fragrance and precipitate the polysaccharides in the dried osmanthus flowers by performing an enzyme extraction reaction on the dried osmanthus flowers, and gradually reduce the water content of the product through multiple drying treatments, thereby obtaining the final powdered osmanthus extract containing a high polysaccharide content.

[0075] In some embodiments, the step S10, performing an enzyme extraction reaction on the dried osmanthus flowers to obtain a crude extract, specifically comprises the following steps:

[0076] placing the dried osmanthus flowers into distilled water;

[0077] In some embodiments, the volume of the distilled water is 6 to 10 times the volume of the dried osmanthus flowers. Specifically, the volume of the distilled water can be set to any one of 6, 7, 8, 9, and 10 times the volume of the dried osmanthus flowers or a range formed between any two values.

[0078] Adding flavor enhancing enzyme to the distilled water to carry out enzyme extraction reaction to obtain the crude extract;

[0079] In some embodiments, the reaction temperature of the enzyme extraction reaction is 40°C to 60°C. Specifically, the reaction temperature of the enzyme extraction reaction can be set to any one of 40°C, 50°C, and 60°C or a range formed between any two values.

[0080] In some embodiments, the reaction time of the enzyme extraction reaction is 60 min to 100 min. Specifically, the reaction time of the enzyme extraction reaction can be set to any one of 60 min, 70 min, 80 min, 90 min, and 100 min or a range formed between any two values.

[0081] In some embodiments, the flavor enhancing enzyme is selected from at least one of α-L-rhamnosidase, α-L-furanosidase, β-D-apiosidase, myrosinase, β-D-glucosidase, α-amyloglucosidase or cellulase.

[0082] In the embodiment of the present application, dried osmanthus flowers are soaked in distilled water to fully absorb water so as to facilitate subsequent enzyme extraction reaction with flavor-enhancing enzymes, and the flavor-enhancing enzymes are added to enhance the osmanthus aroma of the subsequent osmanthus extract.

[0083] In some embodiments, both the first drying treatment and the second drying treatment adopt rotary evaporation, which can achieve rapid drying and precipitation of the product and effectively retain the extracted substance.

[0084] In some embodiments, the ambient temperature of the first drying treatment is 50°C to 70°C. Specifically, the ambient temperature of the first drying treatment can be set to any one of 50°C, 60°C, and 70°C or a range formed between any two values.

[0085] In this embodiment, the step S20 is to extract the supernatant of the crude extract, and perform a first drying treatment on the supernatant under normal pressure until no liquid evaporates to obtain a crude extract.

[0086] In some embodiments, the ambient pressure of the second drying treatment is 0.03 MPa to 0.05 MPa. Specifically, the ambient pressure of the second drying treatment can be set to any one of 0.03 MPa, 0.04 MPa, and 0.05 MPa or a range formed between any two values.

[0087] The ambient temperature of the second drying process is 50° C. to 70° C. Specifically, the ambient temperature of the second drying process can be set to any one of 50° C., 60° C., and 70° C. or a range formed between any two values.

[0088] In some embodiments, in step S30, the crude extract is subjected to a second drying treatment under vacuum conditions until no liquid evaporates to obtain a refined extract.

[0089] In some embodiments, the ambient pressure of the vacuum drying process is 4Pa to 6Pa. Specifically, the ambient pressure of the vacuum drying process can be set to any one of 4Pa, 5Pa, and 6Pa or a range formed between any two values.

[0090] In some embodiments, the ambient temperature of the vacuum drying treatment is -60°C to -80°C. Specifically, the ambient temperature of the vacuum drying treatment can be set to any one of -60°C, -70°C, and -80°C or a range formed between any two values.

[0091] The drying time of the vacuum drying process is 50 hours to 60 hours. Specifically, the drying time of the vacuum drying process can be set to any one of 50 hours, 55 hours, and 60 hours, or a range formed between any two values.

[0092] In the embodiment of the present application, the extract obtained after the first drying treatment and the second drying treatment are subjected to the rotary evaporation treatment twice is further subjected to the vacuum freeze-drying treatment, which can further reduce the water content in the osmanthus extract.

[0093] See also Figure 2 As shown, the present application embodiment also provides a method for preparing an oral product, which is used to prepare the oral product as described above, and specifically comprises the following steps:

[0094] Step S100, providing osmanthus extract, nicotine source, filler, sweetener, pH regulator, and mixing to obtain powder.

[0095] Step S200, providing an adhesive and an ethanol solution, stirring and mixing them to obtain a paste.

[0096] Step S300, mixing the powder and the paste to obtain a primary product, and extruding and granulating the primary product to obtain a granular material.

[0097] Step S400, packaging the granular material to obtain an oral product.

[0098] The preparation method of the oral preparation provided in the embodiment of the present application forms an oral preparation by mixing osmanthus extract with other substances, and utilizes the natural aroma of the osmanthus extract to enhance the taste and aroma of the oral preparation, thereby eliminating the bitter taste produced by the oxidation of the nicotine source and improving the user's taste; at the same time, the polysaccharides contained in the osmanthus extract have a certain antioxidant effect on the nicotine source, thereby delaying the oxidation of the nicotine source, delaying the oxidation and yellowing of the oral preparation, extending the storage period of the oral preparation, and enhancing the user's experience; in addition, the osmanthus extract used as an additive in the present application has a natural aroma and taste compared to conventional flavor additives, which can enhance the user's comfort.

[0099] In some embodiments, the weight proportions of the components in step S100 are as follows:

[0100] 1 to 30 parts of osmanthus extract, 1 to 20 parts of nicotine source, 1 to 40 parts of filler, 1 to 30 parts of sweetener and 1 to 20 parts of pH adjuster.

[0101] In some embodiments, the weight ratio of the adhesive in step S200 is 1 part to 20 parts.

[0102] In some embodiments, the concentration of the ethanol solution in step S200 is 20% to 25%.

[0103] In some embodiments, in step S300, the step of extruding and granulating the primary product to obtain a granular material specifically includes the following steps:

[0104] Performing a first extrusion granulation on the primary product to obtain a secondary product;

[0105] After the secondary product is dried, a second extrusion granulation is performed to obtain the granular material.

[0106] The embodiment of the present application performs secondary extrusion granulation on the primary product to obtain powder particles with a narrow particle size distribution and a nearly spherical or elliptical morphology, so as to facilitate subsequent packaging processing to obtain oral products, thereby improving the production quality and taste uniformity of the oral products.

[0107] In some embodiments, the mesh size of the first extrusion granulation is 40-60 mesh. Specifically, the mesh size of the first extrusion granulation can be set to any one of 40 mesh, 50 mesh, and 60 mesh, or a range formed between any two values.

[0108] In some embodiments, the drying temperature of the drying process is 50°C to 70°C. Specifically, the drying temperature of the drying process can be set to any one of 50°C, 60°C, and 70°C or a range formed between any two values.

[0109] In some embodiments, the drying time of the drying process is 1 h to 2 h. Specifically, the drying time of the drying process can be set to any one of 1 h, 1.5 h, and 2 h, or a range formed between any two values.

[0110] In some embodiments, the mesh size of the second extrusion granulation is 40-60 mesh. Specifically, the mesh size of the second extrusion granulation can be set to any one of 40 mesh, 50 mesh, and 60 mesh or a range formed between any two values.

[0111] The present application is described in detail below through specific embodiments. The following embodiments are only partial embodiments of the present application and are not limitations of the present application.

[0112] Test on the Antioxidant Activity of Osmanthus Extract

[0113] Take 2 ml of osmanthus extract solution and vitamin C solution with concentrations of 0.2%, 0.4%, 0.6%, 0.8%, and 1%, respectively, and mix them with 2 ml of 0.2 mmol / L DPPH solution. After standing at room temperature for 15 minutes, use a spectrophotometer to measure the absorbance of each mixed solution and draw a curve graph, as shown in the figure. Figure 3 shown.

[0114] Wherein, the calculation method of the DPPH free radical scavenging rate is as follows:

[0115] The above osmanthus extract solution or vitamin C solution was mixed with 2 ml of 0.2 mmol / L DPPH solution for 30 minutes, and then the absorbance A1 was measured at 517 nm using a spectrophotometer;

[0116] After 2.0 ml of ethanol solution and 2 ml of 0.2 mmol / L DPPH solution were mixed and reacted for 30 min, the absorbance A2 was measured at 517 nm using a spectrophotometer;

[0117] 2.0 ml of distilled water and 2 ml of 0.2 mmol / L DPPH solution were mixed and reacted for 30 min, and then the absorbance A0 was measured at 517 nm using a spectrophotometer;

[0118] The DPPH free radical scavenging rate was calculated by the following formula:

[0119] Y(%)=[1-(A1-A2) / A0]×100%;

[0120] Wherein, Y is the DPPH free radical scavenging rate.

[0121] according to Figure 3 As shown, it can be known that at the same concentration, the scavenging effect of DPPH free radicals by osmanthus extract solution is better. Therefore, it can be known that osmanthus extract has a good antioxidant effect. When added to oral preparations, the oral preparations have a good anti-aging effect.

[0122] Sensory evaluation of oral products

[0123] Example 1

[0124] Step (1), taking 30 parts of osmanthus extract, 10 parts of nicotine tartrate, 27 parts of microcrystalline cellulose, 5 parts of acesulfame potassium, 10 parts of mannitol, and 15 parts of sodium bicarbonate and mixing them to obtain a powder;

[0125] Step (2), taking 3 parts of povidone K25, adding 25% ethanol solution, stirring and mixing to obtain a paste;

[0126] Step (3), after mixing the powder and the paste, performing a first extrusion granulation through a 50-mesh screen to obtain a secondary product; after baking the secondary product in an oven at 60° C. for 1 hour, performing a second extrusion granulation through a 50-mesh screen to obtain the granular material;

[0127] Step (4) packaging the granular material to obtain the oral product.

[0128] Example 2

[0129] Step (1), taking 25 parts of osmanthus extract, 15 parts of nicotine benzoate, 23 parts of hydroxypropyl methylcellulose (HPMC), 5 parts of acesulfame potassium, 14 parts of maltitol, and 15 parts of sodium carbonate and mixing them to obtain a powder;

[0130] Step (2), taking 3 parts of povidone K30, adding 25% ethanol solution, stirring and mixing to obtain a paste;

[0131] Step (3), after mixing the powder and the paste, performing a first extrusion granulation through a 50-mesh screen to obtain a secondary product; after baking the secondary product in an oven at 60° C. for 1 hour, performing a second extrusion granulation through a 50-mesh screen to obtain the granular material;

[0132] Step (4) packaging the granular material to obtain the oral product.

[0133] Example 3

[0134] Step (1), taking 20 parts of osmanthus extract, 20 parts of nicotine lactate salt, 32 parts of hydroxypropyl methylcellulose (HPMC), 5 parts of acesulfame potassium, 10 parts of xylitol, and 15 parts of potassium carbonate and mixing them to obtain a powder;

[0135] Step (2), taking 3 parts of sodium carboxymethyl cellulose, adding 25% ethanol solution, stirring and mixing to obtain a paste;

[0136] Step (3), after mixing the powder and the paste, performing a first extrusion granulation through a 50-mesh screen to obtain a secondary product; after baking the secondary product in an oven at 60° C. for 1 hour, performing a second extrusion granulation through a 50-mesh screen to obtain the granular material;

[0137] Step (4) packaging the granular material to obtain the oral product.

[0138] Example 4

[0139] Step (1), taking 18 parts of osmanthus extract, 15 parts of resin nicotine salt, 28 parts of microcrystalline cellulose, 5 parts of acesulfame potassium, 15 parts of mannitol, and 15 parts of potassium bicarbonate and mixing them to obtain a powder;

[0140] Step (2), taking 5 parts of sodium carboxymethyl cellulose, adding 25% ethanol solution, stirring and mixing to obtain a paste;

[0141] Step (3), after mixing the powder and the paste, performing a first extrusion granulation through a 50-mesh screen to obtain a secondary product; after baking the secondary product in an oven at 60° C. for 1 hour, performing a second extrusion granulation through a 50-mesh screen to obtain the granular material;

[0142] Step (4) packaging the granular material to obtain the oral product.

[0143] Example 5

[0144] Step (1), taking 15 parts of osmanthus extract, 16 parts of nicotine malate, 27 parts of microcrystalline cellulose, 7 parts of acesulfame potassium, 15 parts of maltitol, and 14 parts of sodium bicarbonate and mixing them to obtain a powder;

[0145] Step (2), taking 6 parts of povidone K25, adding 25% ethanol solution, stirring and mixing to obtain a paste;

[0146] Step (3), after mixing the powder and the paste, performing a first extrusion granulation through a 50-mesh screen to obtain a secondary product; after baking the secondary product in an oven at 60° C. for 1 hour, performing a second extrusion granulation through a 50-mesh screen to obtain the granular material;

[0147] Step (4) packaging the granular material to obtain the oral product.

[0148] Comparative Example 1

[0149] Step (1), taking 20 parts of osmanthus essence, 20 parts of resin nicotine salt, 31 parts of microcrystalline cellulose, 7 parts of acesulfame potassium, 15 parts of xylitol, and 3 parts of sodium carbonate and mixing them to obtain a powder;

[0150] Step (2), taking 4 parts of povidone K30 and adding 25% ethanol solution, stirring and mixing to obtain a paste;

[0151] Step (3), after mixing the powder and the paste, performing a first extrusion granulation through a 50-mesh screen to obtain a secondary product; after baking the secondary product in an oven at 60° C. for 1 hour, performing a second extrusion granulation through a 50-mesh screen to obtain the granular material;

[0152] Step (4) packaging the granular material to obtain the oral product.

[0153] Comparative Example 2

[0154] Step (1), taking 15 parts of nicotine lactate salt, 38 parts of microcrystalline cellulose, 10 parts of maltitol, 25 parts of xylitol, 1 part of sucralose, and 9 parts of sodium bicarbonate and mixing them to obtain a powder;

[0155] Step (2), taking 2 parts of povidone K25 and adding 25% ethanol solution, stirring and mixing to obtain a paste;

[0156] Step (3), after mixing the powder and the paste, performing a first extrusion granulation through a 50-mesh screen to obtain a secondary product; after baking the secondary product in an oven at 60° C. for 1 hour, performing a second extrusion granulation through a 50-mesh screen to obtain the granular material;

[0157] Step (4) packaging the granular material to obtain the oral product.

[0158] In order to further illustrate the beneficial effects of the oral preparation provided by the embodiment of the present invention, the following is further described in detail in conjunction with specific test examples:

[0159] Test: Taste and smoking test

[0160] 1. Test samples: multiple groups of oral products prepared in Examples 1 to 5 and Comparative Examples 1 and 2;

[0161] 2. Formal test: 20 testers conducted the trial and scored the aroma, coolness, sweetness, comfort, headiness, release rate and irritation (the evaluation criteria are shown in Table 1). The average score was taken as the total score for statistical analysis. The test results are shown in Table 2.

[0162]

[0163] Table 1

[0164]

[0165] Table 2

[0166] By comparing the experimental data of Examples 1 to 5 with Comparative Examples 1 and 2, it can be learned that adding osmanthus extract to the oral preparation can greatly improve the fragrance and comfort of the oral preparation.

[0167] By comparing the experimental data of Example 1 with those of Examples 2 to 4, it can be learned that the flavor of the oral preparation can be improved by increasing the amount of osmanthus extract.

[0168] In summary, the oral preparation containing osmanthus extract provided in the embodiments of the present application can have a better aroma effect than existing oral preparations, and the user's comfort during use is better.

[0169] Evaluation of oral product placement

[0170] The oral products prepared in Example 1 and Comparative Example 2 were placed in a constant temperature and humidity chamber (set at 42°C and 60%), and taken out after standing for 28 hours for inspection. Figure 4 As shown (the one on the left is the oral product prepared in Example 1, and the one on the right is the oral product prepared in Example 2).

[0171] By comparing the colors of the two oral preparations, it can be observed that the color of the oral preparation of Example 1 has no obvious change, while the color of the oral preparation of Comparative Example 1 is obviously yellow.

[0172] Therefore, it can be known that the oral preparation provided in the embodiment of the present application can effectively inhibit the oxidation of the nicotine source, improve the antioxidant property of the oral preparation, and prolong the storage time of the oral preparation by adding osmanthus extract.

[0173] Obviously, the embodiments described above are only some embodiments of the present application, rather than all embodiments. The preferred embodiments of the present application are given in the accompanying drawings, but they do not limit the patent scope of the present application. The present application can be implemented in many different forms. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive. Although the present application is described in detail with reference to the aforementioned embodiments, for those skilled in the art, it is still possible to modify the technical solutions recorded in the aforementioned specific implementation methods, or to perform equivalent replacement of some of the technical features therein. Any equivalent structure made using the contents of the specification and drawings of this application, directly or indirectly used in other related technical fields, is similarly within the scope of patent protection of this application.

Claims

1. An oral product, characterized in that: It includes osmanthus extract, nicotine source, filler, sweetener, binder and pH adjuster.

2. The oral product according to claim 1, characterized in that The weight proportions of the components of the oral product are as follows: 1 to 30 parts of osmanthus extract, 1 to 20 parts of nicotine source, 1 to 40 parts of filler, 1 to 20 parts of binder, 1 to 30 parts of sweetener and 1 to 20 parts of pH adjuster.

3. The oral product according to claim 1, characterized in that The nicotine source is selected from at least one of nicotine benzoate salt, nicotine tartaric acid salt, nicotine resin salt, nicotine lactate salt, nicotine salicylate salt, nicotine malate salt, nicotine glycyrrhizic acid salt, and nicotine resin salt; and / or, The filler is selected from at least one of microcrystalline cellulose, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), pea fiber, and a-fiber; and / or, The binder is selected from at least one of povidone K25, povidone K30 and sodium carboxymethyl cellulose; and / or, The sweetener is selected from at least one of acesulfame potassium, sucralose, aspartame, xylitol, maltitol, erythritol, isomalt, mannitol and sorbitol; and / or, The pH regulator is selected from at least one of sodium carbonate, sodium bicarbonate, magnesium oxide, magnesium oxide, potassium hydroxide, potassium carbonate and potassium bicarbonate.

4. A method for extracting osmanthus extract, for preparing the osmanthus extract in the oral preparation according to any one of claims 1 to 3, characterized in that: The following steps are involved: Providing dried osmanthus flowers, and performing an enzyme extraction reaction on the dried osmanthus flowers to obtain a crude extract; Extracting the supernatant of the crude extract, and performing a first drying treatment on the supernatant under normal pressure to obtain a crude extract; Under vacuum conditions, subjecting the crude extract to a second drying treatment to obtain a refined extract; The refined extract is subjected to vacuum drying treatment to obtain a powdered osmanthus extract.

5. The method for extracting osmanthus extract according to claim 4, characterized in that: The step of performing enzyme extraction reaction on the dried osmanthus flowers comprises the following steps: placing the dried osmanthus flowers into distilled water; The flavor enhancing enzyme is added to the distilled water to carry out enzyme extraction reaction to obtain the crude extract.

6. The method for extracting osmanthus extract according to claim 5, characterized in that: The volume of the distilled water is 6 to 10 times the volume of the dried osmanthus flowers; and / or, The reaction temperature of the enzyme extraction reaction is 40°C to 60°C; and / or, The reaction time of the enzyme extraction reaction is 60 min to 100 min; and / or, The flavor enhancing enzyme is selected from at least one of α-L-rhamnosidase, α-L-furanosidase, β-D-apiosidase, myrosinase, β-D-glucosidase, α-amyl glucosidase or cellulase.

7. The method for extracting osmanthus extract according to claim 4, characterized in that: The ambient temperature of the first drying process is 50°C to 70°C; and / or, The ambient pressure of the second drying process is 0.03Mpa to 0.05Mpa; and / or, The ambient temperature of the second drying process is 50°C to 70°C; and / or, The ambient pressure of the vacuum drying process is 4Pa to 6Pa; and / or, The ambient temperature of the vacuum drying process is -60°C to -80°C; and / or, The drying time of the vacuum drying process is 50 hours to 60 hours.

8. A method for preparing an oral product, for preparing the oral product according to any one of claims 1 to 3, characterized in that: The following steps are involved: Providing osmanthus extract, nicotine source, filler, sweetener, and pH regulator, and mixing them to obtain powder; Providing a binder and an ethanol solution, stirring and mixing to obtain a paste; The powder is mixed with the paste to obtain a primary product, and the primary product is extruded and granulated to obtain a granular material; The granular material is packaged to obtain the oral product.

9. The method for preparing the oral product according to claim 8, characterized in that: The step of extruding and granulating the primary product comprises the following steps: Performing a first extrusion granulation on the primary product to obtain a secondary product; After the secondary product is dried, a second extrusion granulation is performed to obtain the granular material.

10. The method for preparing the oral product according to claim 9, characterized in that: The concentration of the ethanol solution is 20% to 25%; and / or, The mesh size of the first extrusion granulation is 40 to 60 meshes; and / or, The drying temperature of the drying treatment is 50°C to 70°C; and / or, The drying time of the drying treatment is 1h to 2h; and / or, The mesh number of the second extrusion granulation screen is 40-60 meshes.

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