Compound plant extract soothing and repairing composition and preparation method thereof

Abstract

The invention relates to a compound plant extract soothing and repairing composition and a preparation method thereof, and belongs to the technical field of cosmetics. The glacier deuterium-depleted water and superoxide dismutase are mixed to obtain a component A, the activity of the superoxide dismutase can be improved by means of the strong dissolving power and permeability of the deuterium-depleted water, meanwhile, a compound extract prepared by mixing a stephania tetrandra extract, a radix gentianae extract and a pepper kava extract is a component C, and after the component C is mixed with the component A, the superoxide dismutase activity can be improved. In the component A, deuterium-depleted water can well bear active ingredients in the plant extract, in the component B, madecassoside and the humectant are mixed, the moisturizing effect can be fully achieved, and the composition obtained after the component A, the component B and the component C are mixed has the excellent relieving and repairing effect.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics and relates to a composite plant extraction soothing and repairing composition and a preparation method thereof. Background Art

[0002] Sensitive skin is mainly manifested by damaged skin barrier function, which is easily affected by external stimuli, causing some inflammatory reactions in the skin, and the skin shows symptoms such as redness, swelling, pain, and burning, which continuously damages skin cells and skin barrier. Repair sensitive skin by moisturizing and soothing sensitive skin, regulating immune balance, enhancing skin immunity, and inhibiting inflammation.

[0003] Damage to the skin barrier is not only a manifestation of many skin diseases, but also an important reason why many skin diseases are prone to recurrence. Therefore, repairing the skin barrier is particularly important for skin health. Summary of the invention

[0004] The object of the present invention is to provide a composite plant extract soothing and repairing composition and a preparation method thereof, wherein the prepared composition has excellent soothing and repairing functions.

[0005] The purpose of the present invention can be achieved through the following technical solutions: A composite plant extract soothing and repairing composition, comprising the following raw materials in parts by weight: Component A: 85-95 parts of deuterium-depleted water, 2-4 parts of superoxide dismutase; Component B: 1-2 parts of madecassoside, 4-8 parts of moisturizer; Component C: 1-2 parts of gentian extract, 1-2 parts of tetrandria extract, 1-2 parts of kava extract; The preparation process of the moisturizing agent is as follows: First, deuterium-depleted water and sodium polyglutamate are mixed, stirred at a speed of 300 r / min for 10 to 15 minutes at 35 to 40° C., and then the acetyl glucosamine solution is added while maintaining the temperature and speed and stirred for 10 to 15 minutes to obtain a mixture D, wherein the mass ratio of deuterium-depleted water, sodium polyglutamate and acetyl glucosamine solution is 15: (2 to 3): (3 to 5); the mixture D is stirred and mixed with dimethyl isosorbide to obtain the moisturizing agent.

[0006] As a preferred technical solution of the present invention, the acetyl glucosamine solution is an acetyl glucosamine aqueous solution with a mass fraction of 10-15%.

[0007] As a preferred technical solution of the present invention, the mass ratio of the mixture D to dimethyl isosorbide is (3-5):1.

[0008] As a preferred technical solution of the present invention, the mixture D and dimethyl isosorbide are stirred and mixed at a rotation speed of 300 r / min for 20 to 25 min.

[0009] As a preferred technical solution of the present invention, the deuterium-depleted water is natural glacier deuterium-depleted water, which is distilled before use and has a deuterium content of less than 140 ppm.

[0010] As a preferred technical solution of the present invention, the deuterium content of the natural glacial deuterium-depleted water is 15-50 ppm.

[0011] A method for preparing a composite plant extract soothing and repairing composition comprises the following steps: S1. Mix deuterium-depleted water and superoxide dismutase according to weight, heat to 60-65°C, and stir at a speed of 200-300 r / min for 30-40 min to obtain component A; S2, mixing madecassoside and the moisturizer with stirring at a speed of 200-300 r / min for 30-50 min to obtain component B; S3, grinding the gentian extract, the tetrandra extract and the kava extract in a ball mill at a speed of 400 r / min for 2 h, passing through a 300-mesh sieve, and stirring and mixing to obtain component C; S4. Stir components A and B at 35-45° C. for 1-2 hours, then continue to add component C, and continue stirring for 35-50 minutes to obtain the composite plant extract soothing and repairing composition.

[0012] As a preferred technical solution of the present invention, in step S3, the rotation speed of the stirring and mixing is 300-400 r / min, and the time is 30 min.

[0013] As a preferred technical solution of the present invention, in step S4, the stirring speed is 350r / min.

[0014] The diameter of the low-deuterium water molecule in the present invention is similar to the diameter of the hydrophilic channel on the cell membrane, so it has stronger permeability and is easier to pass through the cell membrane water channel and combine with the water in the skin cells to form a stable hydration layer, thereby effectively locking in the water and achieving a better moisturizing effect, which is the basis of its soothing and repairing effect. At the same time, low-deuterium water can remove free radicals, inhibit oxidative stress reactions, and alleviate skin aging, dullness and other problems.

[0015] Superoxide dismutase (SOD) can catalyze the conversion of superoxide anion free radicals into hydrogen peroxide and oxygen, effectively reducing oxidative stress, thereby protecting skin cells from damage by free radicals, accelerating skin metabolism, repairing the sebum membrane, maintaining skin moisture, and forming a protective film on the skin surface to enhance skin barrier function; improve cell activity, promote the regeneration and self-repair ability of skin cells, and help improve skin inflammation and soothe the skin.

[0016] Component A of the present invention mixes SOD with deuterium-depleted water. Due to its special molecular structure, deuterium-depleted water is more easily absorbed and utilized by cells, so it can accelerate the metabolic process in cells, thereby enhancing the activity of SOD and enabling SOD to function more efficiently, thereby awakening the activity of skin cells, helping to improve skin inflammation, and soothing the red zone condition of the skin.

[0017] Acetyl glucosamine is hydrophilic and can absorb and retain water molecules, increase the water content of the skin, and improve the skin's moisturizing ability. Mixing the acetyl glucosamine solution with sodium polyglutamate can improve the hydrophilicity of sodium polyglutamate, and then mixing it with dimethyl isosorbide to obtain a moisturizer.

[0018] There are a large number of hydroxyl groups, carboxyl groups and other polar groups in the sodium polyglutamate molecule. These polar groups can form hydrogen bonds within and between molecules, thereby combining and locking a large amount of water. It can form a protective film on the skin surface to effectively prevent water loss; acetyl glucosamine is a molecular precursor of hyaluronic acid, which can promote the synthesis of hyaluronic acid, thereby exerting moisturizing and nourishing effects; dimethyl isosorbide has strong water solubility and can penetrate into the skin, replenish the moisture needed by the skin, and regulate the moisture content of the skin. The combination of these three ingredients can form a complementary moisturizing system to provide all-round and deep moisturizing for the skin.

[0019] At the same time, sodium polyglutamate and acetyl glucosamine both have the ability to repair damaged skin barriers, and have certain repair capabilities while maintaining excellent moisturizing properties.

[0020] Madecassoside can effectively inhibit neutrophils in the skin and reduce the production of inflammatory factors, thereby calming the skin and relieving skin sensitivity. Madecassoside mainly acts on the connective tissue of the skin, helping to accelerate the repair process of damaged tissue and repair the skin barrier. Madecassoside can also promote the expression of collagen in the dermis, enhance the elasticity and firmness of the skin, and accelerate the skin's self-repair process.

[0021] In the present invention, gentian extract, fennel extract and kava extract are used as C component. As plant extracts, the active ingredients in the gentian extract have a strong inhibitory effect on inflammatory factors, can reduce the inflammatory response of tissues, such as redness, swelling, pain, etc., thereby soothing the skin. In addition, the gentian extract can promote the repair of the skin barrier, enhance the defense ability of the skin, and prevent the external harmful substances from invading the skin. The flavonoids and polyphenols in the gentian extract can remove free radicals, reduce the damage of free radicals to the skin, and protect skin cells from oxidative stress.

[0022] The extract of Stephania tetrandra can inhibit inflammatory factors and exert anti-inflammatory effects by blocking the activation of NF-kB. In addition, the extract of Stephania tetrandra can inhibit the release of itch factor histamine by mast cells, effectively relieve skin itching, and soothe sensitive skin. At the same time, the extract of Stephania tetrandra can directly bind to peptidoglycan (PGN) and lipopolysaccharide (LPS), exert antibacterial activity, and has certain antibacterial activity against Staphylococcus aureus.

[0023] Kava extract acts on nerve endings, and its ingredients such as capsaicin occupy skin receptors and inhibit the release of inflammatory mediators, blocking the transmission of information by neurons and inhibiting the transmission of sensitivity, thereby achieving an immediate calming effect. Kava extract also has a significant effect in relieving micro-inflammation of the skin. It can reduce the inflammatory response caused by exposure to a large number of compounds and ultraviolet rays. At the same time, kava extract can improve skin hydration, reduce redness and erythema, effectively soothe skin emotions, relieve redness, hot flashes, stinging and itching, strengthen the microbial barrier, and improve skin resistance.

[0024] Component C of the present invention is a composite extract prepared by mixing Radix Stephaniae Tetrandrae extract, Gentiana extract and Kava Piper methysticum extract. Radix Stephaniae Tetrandrae extract and Gentiana extract both have significant anti-inflammatory effects, and the combination of the two can further enhance the anti-inflammatory effect and effectively alleviate problems such as skin inflammation and redness and swelling. Gentiana extract and Kava Piper methysticum extract both have the effect of calming and soothing the skin, and the combination of the two can quickly relieve skin discomfort and soothe skin emotions. Radix Stephaniae Tetrandrae extract and Kava Piper methysticum extract both have certain antioxidant capacity, and the combination of the two can resist the invasion of free radicals and delay the skin aging process. Therefore, the composite plant extract has significant benefits and synergistic effects, can improve skin condition, enhance skin barrier, and has an effective soothing and repairing effect.

[0025] Beneficial effects of the present invention: The present invention mixes glacial deuterium-depleted water with SOD and utilizes the strong solubility and permeability of deuterium-depleted water itself to improve the activity of SOD. Meanwhile, a composite extract prepared by mixing a Stephania tetrandra extract, a Gentiana scabra extract and a Piper methysticum chuanxiong extract is component C. After being mixed with component A, deuterium-depleted water can well carry the active ingredients in the plant extract. In component B, madecassoside and a moisturizer are mixed to give full play to the moisturizing effect. The composition obtained by mixing components A, B and C has excellent soothing and repairing effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to facilitate understanding by those skilled in the art, the present invention is further described below with reference to the accompanying drawings.

[0027] Figure 1 This is a VISIA red zone diagram of a subject using the composition prepared in Example 1 before use on the first day; Figure 2 This is a VISIA red zone chart of the subject using the composition prepared in Example 1 after 14 days of use, wherein Figure 1 and Figure 2 for the same subject; Figure 3 This is a VISIA red zone diagram of a subject using the composition prepared in Example 2 before use on the first day; Figure 4 This is a VISIA red zone chart of the subject using the composition prepared in Example 2 after 14 days of use, wherein Figure 3 and Figure 4 for the same subject; Figure 5 This is a VISIA red zone diagram of a subject using the composition prepared in Example 3 before use on the first day; Figure 6 This is a VISIA red zone chart of the subject using the composition prepared in Example 3 after 14 days of use, wherein Figure 5 and Figure 6 for the same subject. DETAILED DESCRIPTION

[0028] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0029] In the following examples and comparative examples: The deuterium-depleted water is natural glacier deuterium-depleted water, which is distilled before use and has a deuterium content of less than 140 ppm.

[0030] Sodium polyglutamate: purchased from Zhengzhou Rongyuan Chemical Products Co., Ltd. Acetyl glucosamine: purchased from Hongrui Biotechnology Co., Ltd., catalog number: 448; Isosorbide dimethyl ether: purchased from Jinan Shanhai Chemical Technology Co., Ltd.; Superoxide dismutase: purchased from Shandong Pingju Biotechnology Co., Ltd.; Madecassoside: purchased from Hubei Qifei Pharmaceutical Chemical Co., Ltd. Gentiana extract: purchased from Shaanxi Jianhe Biotechnology Co., Ltd.; Powdered Stephania tetrandra extract: purchased from Shaanxi Sinuote Biotechnology Co., Ltd.; Kava extract: purchased from Shaanxi Snotech Biotechnology Co., Ltd.

[0031] Example 1

[0032] The preparation process of moisturizer is: First, deuterium-depleted water and sodium polyglutamate were mixed, stirred at a speed of 300 r / min for 10 min at 35°C, and then a 10% by mass acetyl glucosamine aqueous solution was added while maintaining the temperature and speed and stirred for 10 min to obtain a mixture D, wherein the mass ratio of deuterium-depleted water, sodium polyglutamate and the acetyl glucosamine aqueous solution was 15:2:3; the mixture D with a mass ratio of 3:1 was stirred and mixed with dimethyl isosorbide to obtain a moisturizer, and the stirring speed during the mixing was 300 r / min and the time was 20 min.

[0033] Preparation of composite plant extract soothing and repairing composition: S1. Mix 85 parts of deuterium-depleted water and 2 parts of superoxide dismutase by weight, heat to 60° C., and stir at 200 r / min for 30 min to obtain component A; S2, mixing 1 part of madecassoside and 4 parts of moisturizer at a speed of 200 r / min for 30 min to obtain component B; S3, grinding 1 part of gentian extract, 1 part of stephania tetrandra extract, and 1 part of Piper mesona extract in a ball mill at a speed of 400 r / min for 2 h, passing through a 300-mesh sieve, and stirring and mixing at a speed of 300 r / min for 30 min to obtain component C; S4. Stir components A and B at 35° C. and 350 r / min for 1 h, then continue to add component C and continue stirring for 35 min to obtain the composite plant extract soothing and repairing composition.

[0034] Example 2

[0035] The preparation process of moisturizer is: First, deuterium-depleted water and sodium polyglutamate were mixed, stirred at a speed of 300 r / min for 12 min at 38°C, and then a 13% acetyl glucosamine aqueous solution was added while maintaining the temperature and speed and stirred for 13 min to obtain a mixture D, wherein the mass ratio of deuterium-depleted water, sodium polyglutamate and acetyl glucosamine aqueous solution was 15:2.5:4; the mixture D with a mass ratio of 4:1 was stirred and mixed with dimethyl isosorbide to obtain a moisturizer, and the stirring speed during the mixing was 300 r / min and the time was 22 min.

[0036] Preparation of composite plant extract soothing and repairing composition: S1. Mix 90 parts of deuterium-depleted water and 3 parts of superoxide dismutase by weight, heat to 62° C., and stir at 250 r / min for 35 min to obtain component A; S2, mixing 1.5 parts of madecassoside and 6 parts of moisturizer at a speed of 250 r / min for 40 min to obtain component B; S3, 1.5 parts of gentian extract, 1.5 parts of stephania tetrandra extract, and 1.5 parts of Piper mesenteriae extract were ball milled at a speed of 400 r / min for 2 h, then passed through a 300-mesh sieve, and stirred and mixed at a speed of 350 r / min for 30 min to obtain component C; S4. Stir components A and B at 40° C. and 350 r / min for 1.5 h, then continue to add component C and continue stirring for 45 min to obtain the composite plant extract soothing and repairing composition.

[0037] Example 3

[0038] The preparation process of moisturizer is as follows: First, deuterium-depleted water and sodium polyglutamate were mixed, stirred at a speed of 300 r / min for 15 min at 40°C, and then a 15% by mass acetyl glucosamine aqueous solution was added while maintaining the temperature and speed and stirred for 15 min to obtain a mixture D, wherein the mass ratio of deuterium-depleted water, sodium polyglutamate and the acetyl glucosamine aqueous solution was 15:3:5; the mixture D with a mass ratio of 5:1 was stirred and mixed with dimethyl isosorbide to obtain a moisturizer, and the stirring speed during the mixing was 300 r / min and the time was 25 min.

[0039] Preparation of composite plant extract soothing and repairing composition: S1. Mix 95 parts of deuterium-depleted water and 4 parts of superoxide dismutase by weight, heat to 65° C., and stir at a speed of 300 r / min for 40 min to obtain component A; S2, stirring and mixing 2 parts of madecassoside and 8 parts of moisturizer at a speed of 300 r / min for 50 min to obtain component B; S3, grinding 2 parts of gentian extract, 2 parts of stephania tetrandra extract and 2 parts of Piper mesenteriae extract in a ball mill at a speed of 400 r / min for 2 h, passing through a 300-mesh sieve, and stirring and mixing at a speed of 400 r / min for 30 min to obtain component C; S4. Stir components A and B at 45° C. and 350 r / min for 2 h, then continue to add component C and continue stirring for 50 min to obtain the composite plant extract soothing and repairing composition.

[0040] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that no acetyl glucosamine aqueous solution is added in the preparation of the moisturizing agent in Comparative Example 1, and the other operations are the same.

[0041] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that superoxide dismutase is not added to component A of Comparative Example 2, and the other operations are the same.

[0042] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that the water used in Comparative Example 3 is deionized water, and the other operations are the same.

[0043] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that component C is not added in Comparative Example 4, and the other operations are the same.

[0044] Test method: The composition prepared by the present invention can be used for direct use by spraying, and the test site is: face.

[0045] After using the sample for 14 days, the subjects evaluated whether the test product had a repairing effect by testing the moisture content of the skin stratum corneum, the transepidermal water loss value, and the skin red zone a value; evaluated whether the test product had a soothing effect by testing the lactic acid stinging level and the skin red zone a value; and evaluated whether the test product had a moisturizing effect by testing the moisture content of the skin stratum corneum.

[0046] The subjects filled out a consumer questionnaire and self-evaluated whether the test product had the effects of soothing, moisturizing, being suitable for sensitive skin, and being gentle and non-irritating.

[0047] The test was conducted after the screened subjects signed the informed consent. A total of 140 subjects participated, with an effective number of 140, including 60 males and 80 females with an average age of 27.8±11.2 years.

[0048] Test method: The subjects cleaned their faces with a facial cleanser, wiped their skin dry with a non-chip-absorbing paper towel, and sat quietly in an environment of 20~22℃, 40%~60%RH for 30 minutes.

[0049] 1. Skin stratum corneum moisture content test results: Instrument: Skin moisture content tester (CM825), unit: CU, the larger the test value, the higher the skin moisture content, the average test results are shown in Table 1: Table 1

[0050] According to the above data, the moisture content of the stratum corneum of the skin of the embodiment group was significantly increased, and the change rates of Examples 1-3 were 86.02%, 84.34%, and 84.29%, respectively, and the change rates of Comparative Example 1 and Comparative Example 3 were 67.18% and 54.35%, respectively. Therefore, it can be explained that the moisturizing effect of the composition can be effectively improved by adding deuterium-depleted water and acetyl glucosamine in the present invention.

[0051] 2. Transepidermal water loss test: Instrument: Skin moisture loss tester (TM Hex), unit: g / m 2 / h, the smaller the test value, the better the skin barrier function. The test results are shown in Table 2: Table 2

[0052] According to the above data, the transepidermal water loss values ​​of Examples 1-3 groups decreased significantly, and the values ​​after 14 days of use were lower than those of the comparative group. The change rates of Examples 1-3 were -57.45%, -51.13%, and -51.14%, respectively, and the change rates of Comparative Examples 1-4 were -41.89%, -25.69%, -33.63%, and -22.41%, respectively. The change rate of the Example group was greater, indicating that the skin barrier function of the Example group was better.

[0053] 3. Skin red zone a value test: Instrument: Facial Skin Image Analysis System (VISIA CR). The smaller the test value, the lower the degree of skin redness. The results are shown in Table 3: Table 3

[0054] According to the above data, the skin red zone a value of the embodiment group decreased significantly after 14 days. The change rates of embodiments 1-3 were -38.61%, -35.26%, and -32.52%, respectively. The greater the change value, the better the skin improvement. The change rates of comparative examples 1-4 were -29.46%, -22.70%, -25.88%, and -19.33%, respectively. Therefore, the change rates of the embodiment group were greater than those of the comparative example group. At the same time, according to the VISIA CR diagram of embodiments 1-3 (see Appendix Figure 1-6) It can be concluded that the composition prepared by the present invention can effectively improve the redness of the skin after use, that is, it has an excellent soothing and repairing effect.

[0055] Therefore, according to the above data, compared with the first day without use, after 14 days of use, the moisture content of the stratum corneum of the subjects' skin increased by more than 80%, and there was a significant difference; the transepidermal water loss value of the subjects decreased by more than 50%, and there was a significant difference; the a value of the red zone of the subjects' skin decreased by more than 30%, and there was a significant difference; therefore, it is shown that the composition prepared by the present invention has repairing, soothing and moisturizing effects.

[0056] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A composite plant extract soothing and repairing composition, characterized in that: The invention comprises the following raw materials in parts by weight: Component A: 85-95 parts of deuterium-depleted water, 2-4 parts of superoxide dismutase; Component B: 1-2 parts of madecassoside, 4-8 parts of moisturizer; Component C: 1-2 parts of gentian extract, 1-2 parts of tetrandria extract, 1-2 parts of kava extract; The preparation process of the moisturizing agent is as follows: First, deuterium-depleted water and sodium polyglutamate are mixed, stirred at a speed of 300 r / min for 10 to 15 minutes at 35 to 40° C., and then the acetyl glucosamine solution is added while maintaining the temperature and speed and stirred for 10 to 15 minutes to obtain a mixture D, wherein the mass ratio of deuterium-depleted water, sodium polyglutamate and acetyl glucosamine solution is 15: (2 to 3): (3 to 5); the mixture D is stirred and mixed with dimethyl isosorbide to obtain the moisturizing agent.

2. The composite plant extract soothing and repairing composition according to claim 1, characterized in that: The acetyl glucosamine solution is an acetyl glucosamine aqueous solution with a mass fraction of 10-15%.

3. The composite plant extract soothing and repairing composition according to claim 1, characterized in that: The mass ratio of the mixture D to dimethyl isosorbide is (3-5):

1.

4. The composite plant extract soothing and repairing composition according to claim 1, characterized in that: The mixture D and dimethyl isosorbide are stirred and mixed at a rotation speed of 300 r / min for 20 to 25 min.

5. The composite plant extract soothing and repairing composition according to claim 1, characterized in that: The deuterium-depleted water is natural glacier deuterium-depleted water, which is distilled before use and has a deuterium content of less than 140 ppm.

6. The composite plant extract soothing and repairing composition according to claim 5, characterized in that: The deuterium content of the natural glacial deuterium-depleted water is 15-50 ppm.

7. A method for preparing the composite plant extract soothing and repairing composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1. Mix deuterium-depleted water and superoxide dismutase according to weight, heat to 60-65°C, and stir at a speed of 200-300 r / min for 30-40 min to obtain component A; S2, mixing madecassoside and the moisturizer with stirring at a speed of 200-300 r / min for 30-50 min to obtain component B; S3, grinding the gentian extract, the tetrandra extract and the kava extract in a ball mill at a speed of 400 r / min for 2 h, passing through a 300-mesh sieve, and stirring and mixing to obtain component C; S4. Stir components A and B at 35-45° C. for 1-2 hours, then continue to add component C, and continue stirring for 35-50 minutes to obtain the composite plant extract soothing and repairing composition.

8. The method for preparing the composite plant extract soothing and repairing composition according to claim 7, characterized in that: In step S3, the stirring and mixing is performed at a speed of 300-400 r / min and for 30 min.

9. The method for preparing the composite plant extract soothing and repairing composition according to claim 7, characterized in that: In step S4, the stirring speed is 350 r / min.

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