Extraction device
By using the sliding plate and return spring acting as buoyant in the extraction device, the problem of large artificial visual judgment error in the prior art is solved, and the accurate separation of immiscible two phases is achieved, and the extraction efficiency is improved.
Patent Information
- Application Number
- CN202411269634.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-11
- Publication Date
- 2025-01-07
AI Technical Summary
The two-phase separation of immiscible phases in existing extraction devices mainly relies on manual visualization, which is prone to errors, especially the judgment error at the separation where the color difference is small, resulting in the upper liquid phase flowing into the lower liquid phase, making it difficult to achieve effective separation. .
An extraction device including a liquid tank, a thin tube and a liquid tube is designed. The thin tube is equipped with a sliding plate and a return spring. The sliding plate moves in the thin tube by buoyancy and observes the position change of the sliding plate to determine the separation of the two phases. Avoid the upper phase entering the lower phase.
Accurate separation of immiscible two phases is achieved, artificial errors are reduced, and extraction efficiency and accuracy are improved.
Smart Images
Figure CN119258591A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to the field of chemical medicine, and in particular to an extraction device. Background Art
[0002] Liquid-liquid extraction is a common operation in the chemical and pharmaceutical fields. Liquid-liquid extraction, also known as solvent extraction or extraction, is the process of separating and extracting components in a liquid mixture with a liquid solvent. An immiscible solvent is added to the liquid mixture, and the different solubilities of the components in the solvent are used to achieve the purpose of separation or extraction. For example, n-butanol is used to extract active pharmaceutical ingredients from aqueous extracts of traditional Chinese medicine.
[0003] The separation of two immiscible phases in existing extraction devices mainly relies on manual visual observation. However, manual visual observation is affected by factors such as personnel operating experience, and large errors are prone to occur in the judgment of the separation point of the two immiscible phases, especially the judgment of the separation point of the two immiscible phases with a small color difference is more prone to large judgment errors, which can easily lead to problems such as the upper liquid phase flowing into the collected lower liquid phase, making it difficult to effectively achieve the separation of the two immiscible phases.
[0004] Therefore, there is a need in the art to develop an extraction device that is convenient for determining the separation of two immiscible phases. Summary of the invention
[0005] The present invention aims to provide an extraction device, which is convenient for determining the separation of two immiscible phases.
[0006] In a first aspect of the present invention, an extraction device is provided, the device comprising a liquid tank 1, a capillary tube 2 and a liquid tube 3;
[0007] One end of the capillary tube is an open end, and the other end of the capillary tube is a closed end. The open end of the capillary tube is connected to the bottom of the liquid tank and communicates with the tank cavity of the liquid tank. A through hole 4 is provided on the side wall of the capillary tube.
[0008] One end of the liquid tube is connected to the bottom of the liquid tank, and the other end of the liquid tube is connected to the through hole on the side wall of the capillary tube. A sliding plate 5 is provided in the lumen of the capillary tube, and the sliding plate is sealedly connected to the inner wall of the lumen of the capillary tube. The lower plate surface of the sliding plate is connected to the inner wall of the closed end of the capillary tube via a reset spring 6.
[0009] The lower plate surface of the sliding plate is located above the through hole on the side wall of the capillary tube, and the lower plate surface of the sliding plate is in contact with the through hole on the side wall of the capillary tube;
[0010] A first liquid outlet pipe 7 is provided on the closed end of the capillary tube, a first valve 8 is provided on the first liquid outlet pipe, a second liquid outlet pipe 9 is provided on the bottom of the liquid tank, a second valve 10 is provided on the second liquid outlet pipe.
[0011] Preferably, the extraction device comprises a liquid-liquid extraction device.
[0012] Preferably, the tank bottom wall of the liquid tank is a plane wall.
[0013] Preferably, the bottom wall of the liquid tank is parallel to the horizontal plane.
[0014] Preferably, a connection point between the open end of the capillary tube and the tank bottom of the liquid tank and a connection point between one end of the liquid tube and the tank bottom of the liquid tank are located on the same horizontal plane.
[0015] Preferably, the open end of the capillary tube is vertically connected to the tank bottom of the liquid tank.
[0016] Preferably, one end of the liquid pipe is vertically connected to the tank bottom of the liquid tank.
[0017] Preferably, the lower plate surface of the sliding plate is vertically connected to the inner wall of the closed end of the capillary tube via a return spring.
[0018] Preferably, the lower plate surface of the sliding plate is vertically connected to the return spring.
[0019] Preferably, the capillary tube comprises a cylindrical tube or a cubic tube.
[0020] Preferably, the lumen of the capillary tube is a cylindrical lumen or a cubic lumen.
[0021] Preferably, the capillary is a transparent capillary.
[0022] Preferably, scale lines are provided on the side wall of the capillary tube.
[0023] Preferably, the scale lines are arranged up and down along the side wall of the capillary tube.
[0024] Preferably, the scale lines can facilitate display of the sliding of the sliding plate in the capillary.
[0025] Preferably, the sliding plate comprises a sliding plug.
[0026] Preferably, the sliding plate is a cylindrical plate or a cubic plate.
[0027] Preferably, the upper and lower plate surfaces of the sliding plate are flat plates.
[0028] Preferably, the upper and lower plate surfaces of the sliding plate are parallel to the horizontal plane.
[0029] Preferably, the sliding plate can slide along the inner wall of the lumen of the capillary tube.
[0030] Preferably, the sliding plate can slide freely along the inner wall of the lumen of the capillary tube.
[0031] Preferably, the closed end of the capillary is located below the through hole.
[0032] Preferably, when no liquid is added to the liquid tank, the lower plate surface of the sliding plate is located above the through hole on the side wall of the capillary tube, and the lower plate surface of the sliding plate is in contact with the through hole on the side wall of the capillary tube.
[0033] Preferably, the other end of the liquid tube is communicated with a through hole on the side wall of the capillary tube.
[0034] Preferably, the tube opening at the other end of the liquid tube is communicated with a through hole on the tube side wall of the capillary tube.
[0035] Preferably, the lumen of the liquid tube is a cylindrical cavity or a cubic cavity.
[0036] Preferably, the liquid tube is a transparent tube.
[0037] Preferably, the liquid pipe is an "L"-shaped pipe.
[0038] Preferably, the narrow tube has the same lumen as that of the liquid tube.
[0039] Preferably, the lower plate surface of the sliding plate contacts the top of the through hole on the side wall of the capillary tube.
[0040] Preferably, the through hole is a circular hole or a square hole.
[0041] Preferably, one end of the liquid tube is communicated with the tank cavity of the liquid tank.
[0042] Preferably, a pipe opening at one end of the liquid pipe is connected to the tank bottom of the liquid tank.
[0043] Preferably, a pipe opening at one end of the liquid pipe is communicated with the tank cavity of the liquid tank.
[0044] Preferably, the tube opening at the other end of the liquid tube is connected to the through hole on the tube side wall of the capillary tube.
[0045] Preferably, the other end of the liquid tube is communicated with the lumen of the capillary tube.
[0046] Preferably, during the liquid-liquid extraction process in the liquid tank, the sliding plate is located in the lumen of the capillary tube.
[0047] Preferably, the sliding plate is located in the lumen of the capillary tube and below the tank bottom of the material tank.
[0048] Preferably, the height between the sliding plate and the tank bottom of the material tank is 1 / 3-3 / 4 of the height of the capillary tube.
[0049] Preferably, during the liquid-liquid extraction process in the liquid tank, the sliding plate is located in the lumen of the capillary tube and below the bottom of the material tank.
[0050] Preferably, during the liquid-liquid extraction process of the liquid tank, the height between the sliding plate and the tank bottom of the material tank is 1 / 3-3 / 4 of the height of the capillary tube.
[0051] Preferably, the liquid tank is a cubic tank or a cylindrical tank.
[0052] Preferably, the liquid tank is also provided with a liquid inlet pipe.
[0053] Preferably, the liquid inlet pipe is located above the liquid tank.
[0054] Preferably, a third valve is also provided on the liquid inlet pipe.
[0055] Preferably, the liquid tank further comprises a heater.
[0056] Preferably, the heater is capable of heating the tank cavity of the liquid tank.
[0057] Preferably, the liquid tank further comprises a stirrer.
[0058] Preferably, the stirrer is capable of stirring the tank cavity of the liquid tank.
[0059] Preferably, the first valve comprises a liquid control valve.
[0060] Preferably, the connection or connection includes communication.
[0061] Preferably, the connection or connection is a fixed connection or a detachable connection.
[0062] It should be understood that within the scope of the present invention, the above-mentioned technical features of the present invention and the technical features specifically described below (such as embodiments) can be combined with each other to form new or preferred technical solutions. BRIEF DESCRIPTION OF THE DRAWINGS
[0063] It should be understood that the drawings are only used for illustrative purposes and should not be construed as limitations on this patent; in order to better illustrate this embodiment, some parts of the drawings may be omitted, enlarged or reduced, and do not represent the size of the actual product; for those skilled in the art, it is understandable that some well-known structures and their descriptions in the drawings may be omitted; the same or similar numbers correspond to the same or similar parts; the terms describing the positional relationship in the drawings are only used for illustrative purposes and should not be construed as limitations on this patent.
[0064] Figure 1 The figure is a schematic diagram of the structure of an extraction device according to a preferred example of the present invention.
[0065] Wherein, each number in the accompanying drawings represents:
[0066] 1 is a liquid tank, 2 is a capillary tube, 3 is a liquid tube, 4 is a through hole, 5 is a sliding plate, 6 is a return spring, 7 is a first liquid outlet pipe, 8 is a first valve, 9 is a second liquid outlet pipe and 10 is a second valve. DETAILED DESCRIPTION
[0067] After extensive and in-depth research, the inventors have developed an extraction device, which includes a liquid tank, a capillary tube and a liquid tube. The extraction device of the present invention facilitates the separation of two immiscible phases, thereby effectively achieving the separation of the two immiscible phases.
[0068] the term
[0069] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
[0070] As used herein, the terms "include", "comprises", and "comprising" are used interchangeably, and include not only open definitions, but also semi-closed and closed definitions. In other words, the terms include "consisting of", "consisting essentially of".
[0071] As used herein, the terms "upper" and "lower" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only used to facilitate description of the invention and simplify the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the invention.
[0072] As used herein, the terms "first" and "second" are used for descriptive purposes only and are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, it is defined that features such as "first" and "second" may explicitly or implicitly include one or more of the features.
[0073] As used herein, the terms “connected” and “connected” should be understood in a broad sense, and may refer to fixed connection or connection, detachable connection or connection, or integral connection or connection.
[0074] For the sake of convenience, the following Figure 1 To further describe the present invention, it should be understood that the accompanying drawings do not limit the scope of the present invention.
[0075] The present invention provides an extraction device, which comprises a liquid tank 1, a capillary tube 2 and a liquid tube 3;
[0076] One end of the capillary tube is an open end, and the other end of the capillary tube is a closed end. The open end of the capillary tube is connected to the bottom of the liquid tank and communicates with the tank cavity of the liquid tank. A through hole 4 is provided on the side wall of the capillary tube.
[0077] One end of the liquid tube is connected to the bottom of the liquid tank, and the other end of the liquid tube is connected to the through hole on the side wall of the capillary tube. A sliding plate 5 is provided in the lumen of the capillary tube, and the sliding plate is sealedly connected to the inner wall of the lumen of the capillary tube. The lower plate surface of the sliding plate is connected to the inner wall of the closed end of the capillary tube via a reset spring 6.
[0078] The lower plate surface of the sliding plate is located above the through hole on the side wall of the capillary tube, and the lower plate surface of the sliding plate is in contact with the through hole on the side wall of the capillary tube;
[0079] A first liquid outlet pipe 7 is provided on the closed end of the capillary tube, a first valve 8 is provided on the first liquid outlet pipe, a second liquid outlet pipe 9 is provided on the bottom of the liquid tank, a second valve 10 is provided on the second liquid outlet pipe.
[0080] The extraction device of the present invention can facilitate the determination of the separation of two immiscible phases, thereby effectively achieving the separation of the two immiscible phases. A typical working principle is as follows:
[0081] (1) After liquid-liquid extraction is performed in the liquid tank, two immiscible liquids (such as aqueous phase liquid and organic phase liquid) are separated into upper and lower layers in the liquid tank, the upper layer is a liquid phase with low density, the lower layer is a liquid phase with high density, and the liquid tube, the tube cavity of the capillary between the lower plate surface of the sliding plate and the closed end of the capillary, and the tube cavity of the capillary between the upper plate surface of the sliding plate and the open end of the capillary are filled with the lower layer phase with high density. At this time, compared with when no liquid is added to the liquid tank, the sliding plate in the tube cavity of the capillary will move a distance toward the tank cavity of the liquid tank due to buoyancy;
[0082] (2) Then, after opening the first valve on the first liquid outlet pipe, the lower phase flows out from the first liquid outlet pipe for collection. When the liquid tank contains the lower phase, the buoyancy of the sliding plate in the lumen of the capillary tube remains unchanged during the process of the lower phase flowing out from the first liquid outlet pipe. Therefore, the position of the sliding plate in the lumen of the capillary tube remains unchanged. When the lower phase in the liquid tank is separated in the liquid tank (that is, when the liquid tank begins to contain no lower phase), the upper phase with low density begins to flow into the liquid tube. At this time, due to the influx of the liquid phase with low density into the liquid tube, the capillary tube The buoyancy of the sliding plate in the lumen begins to decrease, and the sliding plate begins to move in the direction of the reset spring. Therefore, the sliding plate begins to move in the direction of the reset spring, indicating that the lower phase in the liquid tank has been separated in the liquid tank. At this time, the first valve on the first liquid outlet pipe is closed to prevent the upper phase from entering the collected lower phase, thereby achieving effective and accurate separation of the lower phase. Therefore, after liquid-liquid extraction, only by observing that the sliding plate begins to move in the direction of the reset spring, it can be used to accurately judge that the lower phase in the liquid tank has been separated in the liquid tank. After the lower phase is separated from the liquid tank, the liquid tank only contains the upper phase. The second valve on the second liquid outlet pipe is opened to collect the upper phase in the liquid tank.
[0083] It should be understood in the present invention that, compared with the tank cavity volume of the liquid tank, the lumen volumes of the capillary tube and the liquid tube can be set to be negligible.
[0084] The tank bottom wall of the liquid tank described in the present invention may be a plane wall, and the liquid tank may be a cubic tank or a cylindrical tank.
[0085] In a preferred example of the present invention, the connection point between the open end of the capillary tube and the tank bottom of the liquid tank and the connection point between one end of the liquid tube and the tank bottom of the liquid tank are located on the same horizontal plane.
[0086] The tube lumens of the capillary and liquid tube of the present invention may be cylindrical lumens or cubic lumens. Preferably, the capillary is a transparent capillary, through which the sliding of the sliding plate on the inner wall of the tube lumen of the capillary can be easily observed.
[0087] In a preferred example of the present invention, scale lines are provided on the side wall of the capillary tube, and the scale lines can be arranged up and down along the side wall of the capillary tube, and the scale lines can facilitate display of the sliding of the sliding plate in the capillary tube.
[0088] The liquid tank of the present invention may further include a stirrer, which can stir the tank cavity of the liquid tank. When two immiscible liquids are added to the liquid tank, the two liquids can be fully stirred with the stirrer before being allowed to stand for stratification to improve the extraction efficiency. The components of the stirrer of the present invention are not particularly limited, and include (but are not limited to) a stirring blade and the like.
[0089] The main excellent technical effects of the present invention include:
[0090] 1. The present invention develops an extraction device, which is convenient for determining the separation of two immiscible phases, thereby effectively achieving the separation of the two immiscible phases.
[0091] 2. The extraction device of the present invention has simple structure and operation, which is conducive to industrial production.
[0092] The present invention will be further described below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.
[0093] Example 1
[0094] This embodiment 1 provides an extraction device, which includes a liquid tank 1, a capillary tube 2 and a liquid tube 3;
[0095] One end of the capillary tube is an open end, and the other end of the capillary tube is a closed end. The open end of the capillary tube is connected to the bottom of the liquid tank and communicates with the tank cavity of the liquid tank. A through hole 4 is provided on the side wall of the capillary tube.
[0096] One end of the liquid tube is connected to the bottom of the liquid tank, and the other end of the liquid tube is connected to the through hole on the side wall of the capillary tube. A sliding plate 5 is provided in the lumen of the capillary tube, and the sliding plate is sealedly connected to the inner wall of the lumen of the capillary tube. The lower plate surface of the sliding plate is connected to the inner wall of the closed end of the capillary tube via a reset spring 6.
[0097] The lower plate surface of the sliding plate is located above the through hole on the side wall of the capillary tube, and the lower plate surface of the sliding plate is in contact with the through hole on the side wall of the capillary tube;
[0098] A first liquid outlet pipe 7 is provided on the closed end of the capillary tube, a first valve 8 is provided on the first liquid outlet pipe, a second liquid outlet pipe 9 is provided on the bottom of the liquid tank, a second valve 10 is provided on the second liquid outlet pipe;
[0099] The tank bottom wall of the liquid tank is a plane wall.
[0100] The extraction device described in Example 1 facilitates the determination of the separation of two immiscible phases, thereby effectively achieving the separation of the two immiscible phases. The specific working principle is mainly as follows:
[0101] After liquid-liquid extraction is performed in the liquid tank, the two immiscible liquids are separated into upper and lower layers in the liquid tank. After the first valve on the first liquid outlet pipe is opened, the lower phase with high density flows out from the first liquid outlet pipe for collection. When the liquid tank contains the lower phase, the position of the sliding plate in the lumen of the capillary remains unchanged during the process of the lower phase flowing out from the first liquid outlet pipe. When the lower phase in the liquid tank is separated in the liquid tank (that is, when the liquid tank begins to contain no lower phase), the upper phase with low density begins to flow into the liquid tube. At this time, due to the inflow of the liquid phase with high density into the liquid tube, the liquid phase with high density flows into the capillary tube. The buoyancy of the sliding plate in the lumen of the capillary begins to decrease, and the sliding plate begins to move in the direction of the reset spring. The sliding plate begins to move in the direction of the reset spring, indicating that the lower phase in the liquid tank has been separated in the liquid tank. Therefore, just by observing that the sliding plate begins to move in the direction of the reset spring, it can be used to accurately judge that the lower phase in the liquid tank has been separated in the liquid tank. At this time, the first valve on the first liquid outlet pipe is closed to prevent the upper phase from entering the collected lower phase, thereby achieving effective and accurate separation of the lower phase. After the lower phase is separated from the liquid tank, the liquid tank only contains the upper phase. The second valve on the second liquid outlet pipe is opened to collect the upper phase in the liquid tank.
[0102] Therefore, the extraction device described in this embodiment 1 can facilitate the determination of the separation of two immiscible phases, thereby effectively achieving the separation of the two immiscible phases.
[0103] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims
1. An extraction device, characterized in that: The device comprises a liquid tank (1), a capillary tube (2) and a liquid tube (3); One end of the capillary tube is an open end, and the other end of the capillary tube is a closed end. The open end of the capillary tube is connected to the bottom of the liquid tank and communicates with the tank cavity of the liquid tank. A through hole (4) is provided on the side wall of the capillary tube. One end of the liquid tube is connected to the bottom of the liquid tank, and the other end of the liquid tube is connected to a through hole on the side wall of the capillary tube. A sliding plate (5) is provided in the lumen of the capillary tube, and the sliding plate is sealedly connected to the inner wall of the lumen of the capillary tube. The lower plate surface of the sliding plate is connected to the inner wall of the closed end of the capillary tube via a return spring (6). The lower plate surface of the sliding plate is located above the through hole on the side wall of the capillary tube, and the lower plate surface of the sliding plate is in contact with the through hole on the side wall of the capillary tube; A first liquid outlet pipe (7) is provided on the closed end of the capillary tube, a first valve (8) is provided on the first liquid outlet pipe, a second liquid outlet pipe (9) is provided on the bottom of the liquid tank, and a second valve (10) is provided on the second liquid outlet pipe.
2. The extraction device according to claim 1, characterized in that The tank bottom wall of the liquid tank is a plane wall.
3. The extraction device according to claim 1, characterized in that The lumen of the capillary tube is a cylindrical lumen or a cubic lumen.
4. The extraction device according to claim 1, characterized in that The capillary is a transparent capillary.
5. The extraction device according to claim 1, characterized in that: The side wall of the capillary tube is provided with scale lines.
6. The extraction device according to claim 1, characterized in that: The sliding plate can slide freely along the inner wall of the lumen of the capillary.
7. The extraction device according to claim 1, characterized in that: The liquid tube is a transparent tube.
8. The extraction device according to claim 1, characterized in that The narrow tube has the same lumen as that of the liquid tube.
9. The extraction device according to claim 1, characterized in that: The lower plate surface of the sliding plate contacts the top of the through hole on the tube side wall of the capillary tube.
10. The extraction device according to claim 1, characterized in that The liquid tank is a cubic tank or a cylindrical tank.