A fermentation device and a preparation method for preparing a Ganoderma lucidum liver-protecting agent using the device

Abstract

The present application relates to a fermentation device and a method for preparing a liver-protecting agent for the treatment of liver disease using the device, and relates to the field of biological fermentation technology, wherein the main technical solution is a fermentation device, which includes a fermentation tank, a first liquid discharge pipe, a filter tank, a second liquid discharge pipe, a cylindrical filter screen, a driving mechanism, and a uniform distribution mechanism, wherein the fermentation tank is located directly above the filter tank, the upper and lower ends of the first liquid discharge pipe are connected to the bottom of the fermentation tank and the top of the filter tank respectively, and a first switch valve is provided in the first liquid discharge pipe; the second liquid discharge pipe is connected to the bottom of the fermentation tank, and the second liquid discharge pipe is provided with a second switch valve; the filter screen is coaxially arranged with the filter tank, the upper end of the filter screen is rotatably connected to the inner wall of the lower end of the first liquid discharge pipe, the driving mechanism is used to drive the filter screen to rotate around the axis of the filter tank, and the uniform distribution mechanism is used to arrange the medicinal residue on the inner circumference of the filter screen. The present application can reduce the residual medicinal liquid in the medicinal residue to obtain more preparation liquid, thereby increasing the preparation yield.

Description

Technical Field

[0001] The present application relates to the field of biological fermentation technology, and in particular to a fermentation device and a method for preparing a hepatoprotective agent using the device. Background Art

[0002] In traditional Chinese medicine, Tai Sui (Ganoderma lucidum) is known as Meat Ganoderma. It is rich in 46 essential nutrients and active substances required by the human body, including pyrroloquinoline quinone, nucleotides, chitin, flavonoids, polysaccharides, glutathione, saponins, chitin, unsaturated fatty acids, SOD, trace elements, and amino acids. It possesses special effects such as anti-tumor, anti-aging, and immune-enhancing properties.

[0003] Currently, Tai Sui is fermented with Chinese herbal medicine to obtain a preparation, which is then drunk to achieve the effect of assisting in the treatment of diseases.

[0004] The existing fermentation device includes a fermentation tank and a filter screen. That is, the fermentation liquid after fermentation is mixed with drug residues. The filter screen filters out the drug residues in the fermentation liquid to prepare the preparation. However, the drug residues on the filter screen still remain in the fermentation liquid that is difficult to drain, which will lead to a reduction in the amount of the preparation. Summary of the Invention

[0005] In order to increase the yield of preparations, the present application provides a fermentation device and a method for preparing a Tai Sui liver-protecting agent using the device.

[0006] The present application provides a fermentation device, which adopts the following technical solution:

[0007] A fermentation device comprises a fermentation tank, a first drain pipe, a filter tank, a second drain pipe, a cylindrical filter screen, a driving mechanism and a uniform distribution mechanism, wherein the fermentation tank is located directly above the filter tank, the upper end and the lower end of the first drain pipe are respectively connected to the bottom of the fermentation tank and the top of the filter tank, and a first switch valve is provided in the first drain pipe; the second drain pipe is connected to the bottom of the filter tank, and the second drain pipe is provided with a second switch valve; the filter screen is coaxially arranged with the filter tank, the upper end of the filter screen is rotatably connected to the inner wall of the lower end of the first drain pipe, the driving mechanism is used to drive the filter screen to rotate around the axis of the filter tank, and the uniform distribution mechanism is used to distribute the medicinal residue on the inner circumference of the filter screen.

[0008] By adopting the above technical solution, the Tai Sui original liquid composite bacterial liquid and fermentation raw materials are placed in a fermentation tank for fermentation. After the fermentation is completed, the first switch valve is opened, and the fermentation liquid containing the medicinal residue enters the cylindrical filter screen through the first drain pipe. The liquid in the fermentation liquid flows into the filter tank through the mesh of the filter screen and is discharged through the second drain pipe. During this period, the uniform distribution mechanism distributes the medicinal residue in the fermentation liquid on the inner circumference of the filter screen, and the driving mechanism drives the filter screen to rotate. Under the action of centrifugal force, the medicinal liquid remaining on the medicinal residue will separate from the medicinal residue and be discharged from the mesh of the filter screen into the filter tank, that is, the residual medicinal liquid is thrown out, and the thrown medicinal liquid is discharged through the second drain pipe to reduce the medicinal liquid residue in the medicinal residue, thereby greatly improving the obtained amount of the preparation.

[0009] Optionally, the uniform distribution mechanism includes an inner tube, an outer tube, a spiral piece, a fitting with a cylindrical outer circumference and a control limit assembly, wherein the inner tube, outer tube, spiral piece and fitting are all coaxially arranged with the filter screen, the outer tube is passed through the bottom of the filter tank, the outer tube and the filter screen are connected by a one-way bearing, and the driving mechanism is used to drive the outer tube to rotate forward and reverse; the control limit assembly is used to limit the rotation of the filter screen; the spiral piece is fixed to the outer tube, the outer circumference of the spiral piece fits the inner circumference of the filter screen, the inner tube is located in the outer tube, the inner tube and the outer tube are connected to prevent rotation, the fitting is fixed to the inner tube, the outer circumference of the fitting fits the inner circumference of the spiral piece, and the upper end of the fitting has a tapered portion, and the tapered portion is located in the first drainage pipe.

[0010] By adopting the above technical solution, when the fermentation liquid flows down through the first liquid discharge pipe, the fermentation liquid will preferentially flow down along the spiral flow channel formed by the spiral piece, the outer peripheral surface of the fitting and the inner peripheral surface of the filter screen. The driving mechanism drives the outer tube to rotate forward. Since the control limit component limits the rotation of the filter screen, the filter screen does not move, and the outer tube drives the inner tube, the fitting and the spiral piece to rotate forward. The rotation of the spiral piece will drive the medicinal residue in the fermentation liquid to move quickly down to various height positions of the spiral flow channel, so that the medicinal residue is evenly distributed in the spiral flow channel. Then the driving mechanism drives the outer tube to rotate in the opposite direction, and the control limit component releases the limit on the filter screen. The reverse rotation torque of the outer tube will be transmitted to the filter screen through the one-way bearing, causing the inner tube, the fitting, the spiral piece and the filter screen to rotate in the opposite direction. Under the action of centrifugal force, the medicinal residue in the spiral flow channel will be evenly attached to the inner peripheral surface of the filter screen to throw out the residual medicinal liquid.

[0011] Optionally, it also includes a slag discharge mechanism, which includes an air suction assembly and two air jet assemblies, the inner tube is connected to the outer tube in a rotation-resistant and axially sliding manner, and the outer tube is provided with an axial limiting assembly for preventing the inner tube from sliding, and the fitting is configured as a cylindrical airbag, the upper end of the airbag has the tapered portion, the airbag is fixed to the inner tube, and the outer peripheral surface of the airbag fits the inner peripheral surface of the spiral sheet; the upper end of the inner tube is coaxially connected and fixed with a microporous tube, the microporous tube has micropores set through, the diameter of the microporous tube is smaller than the diameter of the inner tube, the microporous tube is located in the airbag, and the air suction assembly is used to extract or inhale air from the inner tube; the two air jet assemblies are symmetrically arranged with the axis of the filter as the center, and the direction of the gas ejected by the air jet assembly is toward the axis of the filter.

[0012] By adopting the above technical solution, in the filtering state, the airbag is filled with air, the outer circumference of the airbag is in contact with the inner circumference of the spiral sheet, and the airbag rotates with the inner tube; after the filtering is completed, the jet assembly blows air, and the filter screen keeps rotating in the opposite direction to blow the medicine residue on the inner circumference of the filter screen to the outer circumference of the airbag and the surface of the spiral sheet, and then the suction assembly inhales air into the airbag, the airbag contracts, and the airbag takes the medicine residue away from the spiral sheet, and then the jet assembly continues to jet to blow the medicine residue on the spiral sheet off and blow it to the vicinity of the inner tube, and move the inner tube downward to drive the airbag to move downward and out of the outer tube, and the medicine residue near the inner tube falls out of the outer tube under the action of gravity, thereby completing the cleaning of the medicine residue.

[0013] That is, by setting up a slag discharge mechanism, under the action of the jet of the jet assembly and the contraction of the airbag, the medicine residue in the spiral flow channel adheres to the outer peripheral surface of the airbag and the medicine residue is blown to the position of the inner tube, and then the inner tube is moved downward and out of the outer tube to realize the cleaning of the medicine residue, which is convenient and quick.

[0014] Optionally, the outer peripheral surface of the airbag is set to be a rough surface.

[0015] By adopting the above technical solution, the adhesion effect of the medicinal residue can be improved, thereby improving the effect of the airbag taking away the medicinal residue.

[0016] Optionally, a spiral diaphragm is provided in the airbag, the inner circumference of the diaphragm is fitted and fixed to the microporous tube, and the outer circumference of the diaphragm is integrally formed with a thickened section, which is fitted and fixed to the inner circumference of the airbag.

[0017] By adopting the above technical solution and providing a diaphragm to form a spiral air cavity, the gas in the air cavity is evenly distributed, making the expansion and contraction of the airbag more stable.

[0018] By setting a thickened section to improve the connection strength between the diaphragm and the airbag, the connection point is not easily stretched and moved due to inflation, and the non-connection point of the airbag is easier to deform. When there is too much gas in the airbag, the outer peripheral surface of the airbag will expand to form a spiral protrusion. The protrusion is located in the spiral flow channel to further squeeze the medicine residue in the spiral flow channel, thereby further increasing the discharge effect of residual medicine liquid.

[0019] Optionally, a plurality of flexible hairs are integrally formed on the outer peripheral surface of the airbag at the spiral gap of the spiral sheet. The flexible hairs are perpendicular to the outer peripheral surface of the airbag. The diameter of the flexible hairs gradually increases in the direction away from the axis of the airbag, and an enveloping gap is formed between adjacent flexible hairs.

[0020] By adopting the above technical solution and setting flexible hairs, when the airbag forms a spiral protrusion, the flexible hairs are in an outward-expanding state, and the entrainment gap is larger, so the medicinal residue pushed away by the air jet can more easily enter the entrainment gap; and when the airbag contracts to take away the medicinal residue, the entrainment gap is smaller, and multiple flexible hairs will grab the medicinal residue to reduce the occurrence of the medicinal residue escaping from the airbag, thereby improving the slag discharge effect.

[0021] Optionally, the control limit assembly includes a limit ring, a first limit rod and a first rubber sleeve, the limit ring sleeve is fixed to the upper end of the filter screen, a first through-hole is vertically opened on the top of the filter tank, the first limit rod is vertically slidably connected to the first through-hole, and the first rubber sleeve is fixed to the inner wall of the first through-hole; the upper surface of the limit ring is provided with a first limit hole for inserting the lower end of the first limit rod.

[0022] By adopting the above technical solution, the rotation limitation and the limiting contact of the filter screen are realized by controlling the cooperation between the first limiting rod and the first limiting hole, which is convenient and quick.

[0023] The present application also provides a method for preparing a hepatoprotective agent using a fermentation device, which adopts the following technical solution:

[0024] A method for preparing a hepatoprotective agent using a fermentation device comprises the following steps:

[0025] S1. Material selection: Cyclocarya paliurus, Scindapsus scindapsus flower, Salvia miltiorrhiza, Gynostemma pentaphyllum, Eucommia ulmoides, Astragalus membranaceus, and Dendrobium officinale were selected as fermentation raw materials;

[0026] S2. Material processing: soak the fermentation raw materials in NaCl solution, then drain and crush them for later use;

[0027] S3. Bacteria culture: Activate the Tai Sui stock solution with mineral water and edible fructose, and culture at a constant temperature of 26°C for 10 days to obtain the Tai Sui stock solution composite bacterial solution;

[0028] S4, inoculation fermentation: fermentation raw materials, Cordyceps sinensis powder, and chromium-enriched yeast are dissolved in pure water to obtain fermentation semi-finished material, and then the Tai Sui stock solution composite bacterial liquid and fermentation semi-finished material are added to the fermentation tank to ferment, and after the fermentation is completed, a fermentation liquid is obtained;

[0029] S5, filtration treatment: the first on-off valve is opened, and the fermentation liquid containing the medicinal residue enters the filter screen through the first drain pipe, and the liquid in the fermentation liquid flows into the filter tank through the mesh of the filter screen and is discharged through the second drain pipe; the uniform distribution mechanism distributes the medicinal residue in the fermentation liquid evenly on the inner circumference of the filter screen, and the driving mechanism drives the filter screen to rotate. Under the action of centrifugal force, the medicinal liquid remaining on the medicinal residue will separate from the medicinal residue and be discharged from the mesh of the filter screen into the filter tank; the medicinal liquid discharged from the second drain pipe is the Tai Sui liver-protecting preparation.

[0030] Optionally, in step S2, the fermentation raw material is first rinsed with tap water, then washed twice with purified water, and finally soaked in a NaCl solution with a mass concentration of 10 g / L for 30 minutes, drained, and then crushed for later use.

[0031] Optionally, the pH value of the Tai Sui liver-protecting preparation is 3.5-4.0.

[0032] In summary, this application includes at least one of the following beneficial technical effects:

[0033] By setting up a filter screen, a driving mechanism and a uniform distribution mechanism, the residual liquid in the drug residue can be effectively thrown out to obtain more preparation liquid, thereby increasing the preparation yield;

[0034] The Tai Sui liver-protecting and liver-protecting preparation prepared by the preparation method is pasteurized and can be directly eaten after adding an appropriate amount of honey. The Tai Sui liver-protecting and liver-protecting preparation has a liver-protecting and liver-protecting effect and has a significant therapeutic effect on metabolic diseases such as hyperglycemia and diabetes.

[0035] By setting up a slag discharge mechanism, under the action of the jet of the jet assembly and the contraction of the airbag, the medicine residue in the spiral flow channel adheres to the outer peripheral surface of the airbag and the medicine residue is blown to the position of the inner tube, and then the inner tube is moved downward and out of the outer tube, so as to realize the cleaning of the medicine residue conveniently and quickly. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 It is a cross-sectional view of the overall structure of Example 1.

[0037] Figure 2 yes Figure 1 A partial enlarged view of point A in the middle.

[0038] Figure 3 yes Figure 1 A partial enlarged view of point B in the middle.

[0039] Figure 4 Schematic diagram of the spiral blade of Example 1.

[0040] Figure 5 yes Figure 1 A partial enlarged view of point C in the middle.

[0041] Figure 6 It is a flow chart of the preparation method of Example 2.

[0042] Figure 7 It is a cross-sectional view of the overall structure of Example 3.

[0043] Figure 8 yes Figure 7 A partial enlarged view of point D in the middle.

[0044] Figure 9 It is a cross-sectional view of the overall structure of Example 4.

[0045] Figure 10 yes Figure 9 A partial enlarged view of point E in the middle.

[0046] Figure 11 It is a partial cross-sectional view of the airbag of Example 5 in an expanded state.

[0047] Figure 12 It is a partial cross-sectional view of the airbag of Example 5 in a deflated state.

[0048] Explanation of reference numerals: 1. fitting; 2. filter screen; 3. outer tube; 5. inner tube; 6. spiral sheet; 7. jet assembly; 10. fermenter; 101. tank body; 102. tank cover; 103. stirring motor; 104. stirring rod; 105. first liquid discharge pipe; 106. first switch valve; 11. tapered portion; 12. air bag; 13. microporous tube; 14. rotary joint; 15. connecting pipe; 16. diaphragm; 161. thickened section; 17. protrusion; 18. flexible hair; 19. entrainment Gap; 20, filter tank; 201, second drain pipe; 202, first through-hole; 21, limiting ring; 22, first limiting rod; 23, first rubber sleeve; 24, first limiting hole; 25, first connecting plate; 26, one-way bearing; 31, second connecting plate; 32, drive motor; 33, gear; 34, ring gear; 35, keyway; 36, second limiting rod; 37, second through-hole; 38, second rubber sleeve; 51, key block; 52, second limiting hole; 71, air pipe; 72, nozzle. DETAILED DESCRIPTION

[0049] The following is combined with Figure 1-12 This application is described in further detail. Example 1

[0050] Example 1 discloses a fermentation device. Figure 1 The fermentation device includes a fermentation tank 10, a first drainage pipe 105, a filter tank 20, a second drainage pipe 201, a cylindrical filter screen 2, a driving mechanism and a uniform distribution mechanism, wherein the fermentation tank 10 is located directly above the filter tank 20, the fermentation tank 10 includes a tank body 101 and a tank cover 102, the upper and lower ends of the first drainage pipe 105 are respectively connected and fixed to the bottom of the fermentation tank 10 and the top of the filter tank 20, a first switch valve 106 is provided in the first drainage pipe 105, the second drainage pipe 201 is connected to the bottom of the filter tank 20, and the second drainage pipe 201 is provided with a second switch valve (not shown in the figure).

[0051] The fermentation tank 10 is used for fermentation. In order to improve the fermentation effect, the fermentation tank 10 can also be provided with a stirring mechanism, which includes a stirring rod 104 and a stirring motor 103. The stirring motor 103 is installed on the tank cover 102, and the stirring rod 104 passes through the tank cover 102 and is located in the tank body 101.

[0052] like Figure 1 、 Figure 2 As shown, the filter screen 2 is located in the filter tank 20, and the filter screen 2 is coaxially arranged with the filter tank 20. The upper end of the filter screen 2 is rotatably connected to the inner wall of the lower end of the first drain pipe 105, and the inner diameter of the filter screen 2 is equal to the inner diameter of the first drain pipe 105. In addition, the filter tank 20 is provided with a control limit assembly, which is used to limit the rotation of the filter screen 2 or release the limit of the filter screen 2. Specifically, the control limit assembly includes a limit ring 21, a first limit rod 22 and a first rubber sleeve 23. The limit ring 21 is fixed to the upper end of the filter screen 2, and the upper surface of the limit ring 21 is in contact with the inner top wall of the filter tank 20. The top of the filter tank 20 A first through-hole 202 is vertically opened on the top, and the first limiting rod 22 is vertically slidably connected to the first through-hole 202. The first rubber sleeve 23 is fixed to the inner wall of the first through-hole 202, so that the sliding of the first limiting rod 22 has damping. The upper surface of the limiting ring 21 is provided with a first limiting hole 24 for inserting the lower end of the first limiting rod 22, that is, through the cooperation between the first limiting rod 22 and the first limiting hole 24, the filter screen 2 and the filter tank 20 are relatively fixed, and the movement of the first limiting rod 22 can be manual or automatic. In other embodiments, an electric push rod can be set on the top of the filter tank 20, and the electric push rod drives the first limiting rod 22 to move vertically.

[0053] like Figure 1 、 Figure 3 、 Figure 4When the filter screen 2 is in the air, the filter screen 2 is rotated by the outer tube 3 and the outer tube 3 is rotated by the one-way bearing 26.

[0054] The driving mechanism includes a driving motor 32, a ring gear 34 and a gear 33. The driving motor 32 is installed at the bottom of the filter tank 20, the gear 33 is installed on the output shaft of the driving motor 32, and the ring gear 34 is fixed on the part of the outer tube 3 located outside the filter tank 20. The gear 33 and the ring gear 34 are engaged.

[0055] like Figure 1 、 Figure 3 、 Figure 4 As shown, the outer circumferential surface of the spiral piece 6 is attached to the inner circumferential surface of the filter screen 2, and the spiral piece 6 is fixed to the outer tube 3, that is, the outer tube 3 can drive the spiral piece 6 to rotate. Specifically, the upper end of the outer tube 3 is fixed with an annular second connecting plate 31, the second connecting plate 31 is coaxial with the outer tube 3, the second connecting plate 31 is attached to the upper surface of the first connecting plate 25, and the lower end of the spiral piece 6 is fixed to the second connecting plate 31.

[0056] The inner tube 5 is located inside the outer tube 3. The outer diameter of the inner tube 5 is smaller than the inner diameter of the outer tube 3. There is an annular gap between the inner tube 5 and the outer tube 3. The inner tube 5 is connected to the outer tube 3 to prevent rotation. Specifically, a key groove 35 is axially penetrated through the inner circumference of the outer tube 3. A key block 51 is fixed to the outer circumference of the inner tube 5. The key block 51 is connected to the key groove 35 in an axial sliding manner along the outer tube 3, so that the torque of the outer tube 3 can be transmitted to the inner tube 5.

[0057] In order to limit the axial position of the inner tube 5, the outer tube 3 is also provided with an axial limiting component, such as Figure 5 As shown, it includes a second limiting rod 36 and a second rubber sleeve 38. The outer tube 3 is radially provided with a second through-hole 37. The second limiting rod 36 is vertically slidably connected to the second through-hole 37. The second rubber sleeve 38 is fixed to the inner wall of the second through-hole 37 so that the sliding of the second limiting rod 36 is damped. The outer circumference of the inner tube 5 is provided with a second limiting hole 52 for inserting the end of the second limiting rod 36.

[0058] The upper end of the inner tube 5 is fixed to the bottom of the fitting 1. The fitting 1 can be a cylindrical metal part or a cylindrical hollow tube. The outer circumferential surface of the fitting 1 is attached to the inner circumferential surface of the spiral sheet 6. The bottom of the fitting 1 is attached to the upper surface of the second connecting plate 31. The upper end of the fitting 1 has a tapered portion 11, and the tapered portion 11 is located in the first drainage pipe 105.

[0059] The implementation principle of Example 1 is as follows: the original liquid composite bacteria liquid of Tai Sui and the fermentation raw materials are placed in the fermentation tank 10 for fermentation. After the fermentation is completed, the first switch valve 106 is opened, and the fermentation liquid containing the medicinal residue enters the cylindrical filter screen 2 through the first drainage pipe 105. The liquid in the fermentation liquid flows into the filter tank 20 through the mesh of the filter screen 2 and is discharged through the second drainage pipe 201. The fermentation liquid preferentially flows down along the spiral flow channel formed by the spiral piece 6, the outer peripheral surface of the fitting 1, and the inner peripheral surface of the filter screen 2. The driving mechanism drives the outer tube 3 to rotate forward. Since the control limit assembly limits the rotation of the filter screen 2, the filter screen 2 does not move, and the outer tube 3 drives the inner tube 5, the fitting 1 and the spiral piece 6 to rotate forward. The rotation of the spiral piece 6 will drive the fermentation liquid The medicinal residue quickly moves down to various height positions of the spiral flow channel, so that the medicinal residue is evenly distributed in the spiral flow channel, and then the driving mechanism drives the outer tube 3 to rotate in the opposite direction, and controls the limit component to release the limit on the filter screen 2 (the first limit rod 22 disengages from the first limit hole 24), so that the filter screen 2 is in a free rotation state, and the reverse rotation torque of the outer tube 3 will be transmitted to the filter screen 2 through the one-way bearing 26 to drive the inner tube 5, the fitting 1, the spiral sheet 6 and the filter screen 2 to rotate in the opposite direction. Under the action of centrifugal force, the medicinal residue in the spiral flow channel will be evenly attached to the inner circumference of the filter screen 2 and continue to rotate to throw out the residual liquid medicine. The thrown liquid medicine is discharged through the second drain pipe 201 to reduce the residual liquid medicine in the medicinal residue, thereby greatly improving the amount of preparation obtained.

[0060] When the medicinal residue needs to be discharged, the driving mechanism stops driving, the axial limit of the inner tube 5 is released (the second limit rod 36 disengages from the second limit hole 52), and the inner tube 5 is moved upward to bring the fitting 1 away from the second connecting plate 31. Then water is introduced into the fermentation tank 10, and the water will enter the spiral flow channel in the filter screen 2 from the first drain pipe 105 to drive the medicinal residue in the spiral flow channel to move downward. The medicinal residue will pass through the gap between the bottom of the fitting 1 and the second connecting plate 31, and the gap between the inner tube 5 and the outer tube 3 in turn, and finally be discharged from the lower end of the outer tube 3, thereby completing the cleaning of the medicinal residue. Example 2

[0061] Example 2 discloses a method for preparing a liver-protecting agent using a fermentation device, such as Figure 6 As shown, the following steps are included:

[0062] S1. Material selection: Cyclocarya paliurus, Epimedium flower, Salvia miltiorrhiza, Gynostemma pentaphyllum, Eucommia ulmoides, Astragalus membranaceus, and Dendrobium officinale are selected as fermentation raw materials.

[0063] S2. Material processing: Rinse the fermentation raw materials with tap water first, then wash twice with purified water, and finally soak them in a 10g / L NaCl solution for 30 minutes, drain and crush them for later use.

[0064] S3. Bacteria culture: Use mineral water to activate the scientifically cultured Tai Sui stock solution. The specific method is to take 50 mL of Tai Sui stock solution, add 400 mL of mineral water and 50 mL of edible fructose, and culture at a constant temperature of 26°C for 10 days to obtain 500 mL of Tai Sui stock solution composite bacterial liquid.

[0065] S4. Inoculation and fermentation: according to the inoculation ratio of 30%, the fermentation raw materials, cicada fungus and cordyceps powder, and chromium-rich yeast are dissolved in pure water to obtain a fermentation semi-finished material, and then the Gastrodia elata stock solution composite bacteria solution (the concentration of the Gastrodia elata stock solution composite bacteria is 106 CFU / ml) and the fermentation semi-finished material are added to the fermentation tank 10 and fermented for 15 days at a temperature of 25-32°C. After fermentation is mature, the pH value of the fermentation liquid is 3.5-4.0.

[0066] S5, Filtration Process: The first on-off valve 106 is opened, and the fermentation liquid containing the medicinal residue enters the filter screen 2 through the first drainage pipe 105. The liquid in the fermentation liquid flows into the filter tank 20 through the mesh of the filter screen 2 and is discharged through the second drainage pipe 201. The driving mechanism drives the filter screen 2 to rotate, and the uniform distribution mechanism distributes the medicinal residue in the fermentation liquid evenly on the inner circumference of the filter screen 2. Under the action of centrifugal force, the medicinal liquid remaining on the medicinal residue will separate from the medicinal residue and be discharged from the mesh of the filter screen 2 into the filter tank 20 and discharged from the second drainage pipe 201.

[0067] The liquid medicine discharged from the second liquid discharge pipe 201 is a liver-protecting preparation of Tai Sui, which has a pH value of 3.5 to 4.0. After pasteurization, the liver-protecting preparation of Tai Sui can be directly consumed by adding an appropriate amount of honey. Example 3

[0068] The difference between Example 3 and Example 1 is that Figure 7 、 Figure 8 As shown, the fermentation device also includes a slag discharge mechanism for improving the cleaning effect of the medicinal residue.

[0069] The slag discharge mechanism includes a suction air component and two jet components 7. The fitting 1 is set as a cylindrical airbag 12. The airbag 12 is made of rubber. The outer peripheral surface of the airbag 12 is set as a rough surface. The upper end of the airbag 12 is conical, that is, the upper end of the airbag 12 is a conical portion 11. The upper end of the inner tube 5 is coaxially connected and fixed with a microporous tube 13. The diameter of the microporous tube 13 is smaller than the diameter of the inner tube 5. The microporous tube 13 has micropores (not marked in the figure) arranged through it. The microporous tube 13 is located in the airbag 12. The lower end of the airbag 12 is fixedly connected to the upper end of the inner tube 5. The upper end of the airbag 12 is fixedly connected to the upper end of the microporous tube 13, so that the torque of the inner tube 5 can be transmitted to The air bag 12 and the suction air component are used to evacuate or inhale the inner tube 5. The suction air component includes a connecting tube 15 and a suction pump (not shown in the figure). The connecting tube 15 is a hose. One end of the connecting tube 15 is connected to the lower end of the inner tube 5 through a rotary joint 14, and the other end of the connecting tube 15 is connected to the suction pump. When the connecting tube 15 is connected to the suction end of the suction pump, the air bag 12 can be inhaled. When the connecting tube 15 is connected to the discharge end of the suction pump, the air bag 12 can be blown. The outer peripheral surface of the inflated air bag 12 is attached to the inner peripheral surface of the spiral sheet 6 to form a complete spiral flow channel to facilitate the uniform distribution of the medicinal residue.

[0070] The two jet assemblies 7 are symmetrically arranged with the axis of the filter 2 as the center. The jet assembly 7 includes multiple air pipes 71 and nozzles 72. The air pipes 71 are arranged at intervals along the axial direction of the filter tank 20. The air pipes 71 pass through the filter tank 20, and the nozzles 72 are installed at the ends of the air pipes 71. The direction of the gas ejected by the nozzles 72 is toward the axis of the filter 2.

[0071] After the filtration is completed, the filter screen 2 keeps rotating in the reverse direction at a slow speed, and the medicine residue is located on the inner peripheral surface of the filter screen 2. The nozzle 72 blows air to blow the medicine residue on the inner peripheral surface of the filter screen 2 to the outer peripheral surface of the air bag 12 (part of the medicine residue adheres to the outer peripheral surface of the air bag 12) and the surface of the spiral piece 6. Then the suction air component sucks air into the air bag 12, and the air bag 12 shrinks toward the microporous tube 13. The air bag 12 gradually fits the microporous tube 13, and the air bag 12 takes the medicine residue away from the spiral piece 6. Then the jet component 7 continues to jet to blow the medicine residue on the spiral piece 6 down and blow it to the vicinity of the inner tube 5 (near the microporous tube 13). Then the axial limit component is released and the inner tube 5 is moved downward to drive the air bag 12 to move downward and move out of the outer tube 3. The medicine residue near the inner tube 5 also falls out of the outside of the outer tube 3 under the action of gravity. Finally, the medicine residue on the outer surface of the air bag 12 is cleaned, thereby completing the cleaning of the medicine residue.

[0072] When filtering is required again, the cleaned air bag 12 is inserted into the filter screen 2 from the outer tube 3 and reinstalled. Example 4

[0073] The difference between Example 4 and Example 3 is that Figure 9 、 Figure 10As shown, a spiral diaphragm 16 is provided in the airbag 12. Specifically, the diaphragm 16 is made of the same material as the airbag 12. The inner circumference of the diaphragm 16 is adhered to and bonded to the microporous tube 13. The outer circumference of the diaphragm 16 is integrally formed with a thickened section 161. The thickened section 161 is adhered to and bonded to the inner circumference of the airbag 12. Since the diaphragm 16 is spiral, the thickened section 161 is also spiral. The connection position between the airbag 12 and the thickened section 161 is also spiral, and the connection position is opposite to the inner circumference of the spiral sheet 6.

[0074] Thickened section 161 strengthens the connection between diaphragm 16 and airbag 12, making this connection less susceptible to stretching and movement due to overinflation. In contrast, the non-connected portion of airbag 12 is more susceptible to deformation. Therefore, when excess gas is present within airbag 12, the outer surface of airbag 12 expands to form a spiral protrusion 17. This protrusion 17, located within the spiral flow channel, further squeezes the drug residue within the spiral flow channel, thereby further enhancing the removal of residual drug liquid. Furthermore, the thickness of the airbag 12 located at protrusion 17 can be reduced to make it more susceptible to expansion and deformation. Example 5

[0075] The difference between Example 5 and Example 4 is that Figure 11 、 Figure 12 As shown, a plurality of flexible hairs 18 are integrally formed on the outer peripheral surface of the airbag 12 at the spiral gap of the spiral sheet 6, that is, a plurality of flexible hairs 18 are integrally formed on the outer peripheral surface of the protrusion 17. The flexible hairs 18 are perpendicular to the outer peripheral surface of the protrusion 17. The diameter of the flexible hairs 18 gradually increases in the direction away from the axis of the airbag 12, and an entrainment gap 19 is formed between adjacent flexible hairs 18.

[0076] When the airbag 12 forms the spiral protrusion 17, the flexible hair 18 is in an outward expansion state (see Figure 11 ), the entrainment gap 19 is larger, so the medicine residue pushed away from the filter screen 2 by the air jet is more likely to enter the entrainment gap 19, and when the air bag 12 contracts to take away the medicine residue, due to the presence of the thickened section 161, the protrusion 17 is preferentially concave, making the entrainment gap 19 smaller (see Figure 12 ), multiple flexible hairs 18 jointly grasp the medicinal residue to reduce the occurrence of the medicinal residue escaping from the air bag 12, thereby improving the slag discharge effect.

[0077] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A fermentation device, characterized in that: The invention comprises a fermentation tank (10), a first liquid discharge pipe (105), a filter tank (20), a second liquid discharge pipe (201), a cylindrical filter screen (2), a driving mechanism, a uniform distribution mechanism and a slag discharge mechanism, wherein the fermentation tank (10) is located directly above the filter tank (20), the upper end and the lower end of the first liquid discharge pipe (105) are respectively connected to the bottom of the fermentation tank (10) and the top of the filter tank (20), and a first switch valve (106) is provided in the first liquid discharge pipe (105); the second liquid discharge pipe (201) is connected to the bottom of the filter tank (20), and the second liquid discharge pipe (201) is provided with a second switch valve; the filter screen (2) is coaxially arranged with the filter tank (20), and the upper end of the filter screen (2) is connected to the lower end of the first liquid discharge pipe (105). The inner wall is rotatably connected, the driving mechanism is used to drive the filter screen (2) to rotate around the axis of the filter tank (20), and the uniform distribution mechanism is used to arrange the medicine residue on the inner peripheral surface of the filter screen (2); the uniform distribution mechanism includes an inner tube (5), an outer tube (3), a spiral piece (6), a matching piece (1) with a cylindrical outer peripheral surface, and a control limit assembly, wherein the inner tube (5), the outer tube (3), the spiral piece (6), and the matching piece (1) are all coaxially arranged with the filter screen (2), the outer tube (3) is passed through the bottom of the filter tank (20), and the outer tube (3) is connected to the filter screen (2) through a one-way bearing (26), and the driving mechanism is used to drive the outer tube (3) to rotate forward and reverse; the control limit assembly is used to rotate the filter screen (2) Dynamic limit; the spiral piece (6) is fixedly arranged with the outer tube (3), the outer peripheral surface of the spiral piece (6) is in contact with the inner peripheral surface of the filter screen (2), the inner tube (5) is located in the outer tube (3), the inner tube (5) and the outer tube (3) are connected to each other in a rotation-stop manner, the fitting (1) is fixedly connected with the inner tube (5), the outer peripheral surface of the fitting (1) is in contact with the inner peripheral surface of the spiral piece (6), and the upper end of the fitting (1) has a tapered portion (11), and the tapered portion (11) is located in the first liquid discharge pipe (105); the slag discharge mechanism includes a suction gas component and two jet components (7), the inner tube (5) is connected to the outer tube (3) in an axial sliding manner, and the outer tube (3) is provided with an axial limit component for preventing the inner tube (5) from sliding. The matching part (1) is configured as a cylindrical airbag (12), the upper end of the airbag (12) has the tapered portion (11), the airbag (12) is fixed to the inner tube (5), and the outer peripheral surface of the airbag (12) is in contact with the inner peripheral surface of the spiral sheet (6); the upper end of the inner tube (5) is coaxially connected and fixed with a microporous tube (13), the microporous tube (13) has micropores arranged therethrough, the diameter of the microporous tube (13) is smaller than the diameter of the inner tube (5), the microporous tube (13) is located in the airbag (12), and the suction component is used to pump or inhale air from the inner tube (5); the two jet components (7) are symmetrically arranged with the axis of the filter (2) as the center, and the direction of the gas ejected by the jet component (7) is toward the axis of the filter (2);The air bag (12) is provided with a spiral diaphragm (16), the inner peripheral surface of the diaphragm (16) is fixedly attached to the microporous tube (13), and the outer peripheral surface of the diaphragm (16) is integrally formed with a thickened section (161), and the thickened section (161) is fixedly attached to the inner peripheral surface of the air bag (12); the suction air component blows air to the air bag (12), and the outer peripheral surface of the inflated air bag (12) is attached to the inner peripheral surface of the spiral sheet (6) to form a spiral flow channel; under the jetting action of the jetting component (7) and the contraction of the air bag (12), the drug residue in the spiral flow channel adheres to the outer peripheral surface of the air bag (12) and the drug residue is blown to the position of the inner tube (5), and then the inner tube (5) is moved downward, and the inner tube (5) is moved out of the outer tube (3) to achieve the cleaning of the drug residue.

2. The fermentation device according to claim 1, characterized in that: The outer peripheral surface of the airbag (12) is set as a rough surface.

3. The fermentation device according to claim 1, characterized in that: A plurality of flexible hairs (18) are integrally formed on the outer peripheral surface of the airbag (12) at the spiral gap of the spiral sheet (6). The flexible hairs (18) are perpendicular to the outer peripheral surface of the airbag (12). The diameter of the flexible hairs (18) gradually increases in a direction away from the axial center of the airbag (12), and an enveloping gap (19) is formed between adjacent flexible hairs (18).

4. The fermentation device according to claim 1, characterized in that: The control limit assembly comprises a limit ring (21), a first limit rod (22) and a first rubber sleeve (23); the limit ring (21) is sleeved and fixed on the upper end of the filter screen (2); a first through hole (202) is vertically opened on the top of the filter tank (20); the first limit rod (22) is vertically slidably connected to the first through hole (202); the first rubber sleeve (23) is fixed to the inner wall of the first through hole (202); and a first limit hole (24) is opened on the upper surface of the limit ring (21) for inserting the lower end of the first limit rod (22).

5. A method for preparing a hepatoprotective agent using the fermentation device according to claim 1, characterized in that: The following steps are involved: S1. Material selection: Cyclocarya paliurus, Scindapsus scindapsus flower, Salvia miltiorrhiza, Gynostemma pentaphyllum, Eucommia ulmoides, Astragalus membranaceus, and Dendrobium officinale were selected as fermentation raw materials; S2. Material processing: soak the fermentation raw materials in NaCl solution, drain and crush them for later use; S3. Bacteria culture: Activate the Tai Sui stock solution with mineral water and edible fructose, and culture at a constant temperature of 26°C for 10 days to obtain the Tai Sui stock solution composite bacterial solution; S4, inoculation and fermentation: dissolving the fermentation raw materials, Cordyceps sinensis powder, and chromium-enriched yeast in purified water to obtain a fermentation semi-finished material, and then adding the Gastrodia elata stock solution composite bacterial liquid and the fermentation semi-finished material into the fermentation tank (10) to carry out fermentation, and obtaining a fermentation liquid after the fermentation is completed; S5, filtration treatment: the first switch valve (106) is opened, and the fermentation liquid containing the medicinal residue enters the filter screen (2) through the first drainage pipe (105), and the liquid in the fermentation liquid flows into the filter tank (20) through the mesh of the filter screen (2) and is discharged through the second drainage pipe (201); the uniform distribution mechanism uniformly distributes the medicinal residue in the fermentation liquid on the inner peripheral surface of the filter screen (2), and the driving mechanism drives the filter screen (2) to rotate. Under the action of centrifugal force, the medicinal liquid remaining on the medicinal residue will separate from the medicinal residue and be discharged from the mesh of the filter screen (2) into the filter tank (20); the medicinal liquid discharged from the second drainage pipe (201) is the Tai Sui liver-protecting preparation.

6. The method for preparing the Tai Sui liver-protecting agent according to claim 5, characterized in that: In step S2, the fermentation raw materials are first rinsed with tap water, then washed twice with purified water, and finally soaked in a NaCl solution with a mass concentration of 10 g / L for 30 minutes, drained, and then crushed for later use.

7. The method for preparing the Tai Sui liver-protecting agent according to claim 5, characterized in that: The pH value of the Tai Sui liver-protecting preparation is 3.5-4.0.

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