Filter module, method for producing same, and use of filter module

Through inline saponification technology in the filter module, the problem of insufficient connection between the membrane and the boundary member is solved, the spontaneous wetting and fluid sealing of the membrane is achieved, and the sterile filtration and high-performance filtration are ensured, which reduces the industrialization Impact of biopharmaceutical applications.

CN119278088APending Publication Date: 2025-01-07SARTORIUS STEDIM BIOTECH GMBH
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Patent Information

Application Number
CN202380043009.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-06-30
Filing Date
2023-06-29
Publication Date
2025-01-07

AI Technical Summary

Technical Problem

When using incompatible materials in existing filter modules, the membrane and boundary members are not connected sufficiently, resulting in the inability to meet the fluid sealing requirements of sterile filtration or other filtration technologies, and the addition of auxiliary substances may affect the filtration performance or contaminate the filtrate. .

Method used

Inline saponification technology is adopted to connect the peripheral area of ​​the film to the boundary member, and then saponify it in the area other than the connecting area, making the film surface hydrophilic without affecting the physical and chemical properties of the body, ensuring fluid sealing and mechanical stability.

Benefits of technology

The spontaneous wetting and fluid-sealing connection of the membrane is achieved, ensuring high performance of the membrane in sterile filtration or other filtration technologies by controlling the degree of hydrolysis, reducing the impact on industrial biopharmaceutical applications.

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Abstract

The present invention relates to a filter module comprising an ester-based membrane and at least one boundary member, where a peripheral region of the membrane is connected to the at least one boundary member, and where a surface of the membrane is saponified in a region other than the peripheral region connected to the at least one boundary member. The invention further relates to a method for producing such a filter module and to the use of such a filter module.
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Claims

1. A filter module comprising an ester-based membrane and at least one boundary member, in, A peripheral region of the membrane is connected to the at least one boundary member, and wherein the surface of the film is saponified in an area other than the peripheral area connected to the at least one boundary member.

2. The filter module according to claim 1, wherein: The ester constituting the film is a cellulose ester.

3. The filter module according to claim 2, wherein: The cellulose ester is cellulose acetate.

4. The filter module according to any one of claims 1 to 3, wherein: The membrane has a tubular shape and the at least one boundary member is an end cap.

5. The filter module according to any one of claims 1 to 3, wherein: The membrane has a flat shape, and the at least one boundary member is a frame.

6. The filter module according to any one of claims 1 to 5, wherein: The at least one boundary member is formed from a polyolefin.

7. The filter module according to claim 6, wherein: The polyolefin is polypropylene.

8. The filter module according to any one of claims 1 to 7, wherein: The membrane was not reinforced with nonwoven material.

9. The filter module according to any one of claims 1 to 8, wherein: In the region other than the peripheral region connected to the at least one boundary member, the film has a saponification degree SaD in the range of 15% to 75%. 膜 .

10. The filter module according to any one of claims 1 to 9, wherein: In the area other than the peripheral area connected to the at least one boundary member, the membrane has a dimensional change in water in the range of 1% to 4%.

11. A method of manufacturing a filter module comprising an ester-based membrane and at least one boundary member, the method comprising the following steps (a) to (c) in sequence: (a) providing a membrane made of ester and at least one boundary member; (b) connecting the peripheral region of the membrane to the at least one boundary member, thereby obtaining a precursor of the filter module; and (c) saponifying the surface of the membrane in an area other than the peripheral area connected to the at least one boundary member, thereby obtaining the filter module.

12. The manufacturing method according to claim 11, wherein: Step (c) comprises flushing the precursor of the filter module with a solution containing a base.

13. The manufacturing method according to claim 12, wherein: The base contained in the solution is chosen from hydroxides and carbonates of alkali metals and alkaline earth metals and from ammonia.

14. The manufacturing method according to claim 12 or 13, wherein: Autoclaving is performed after rinsing in step (c).

15. Use of a filter module according to any one of claims 1 to 10 for sterile filtration.

Citation Information

Patent Citations

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