Traditional Chinese medicine composition with effects of purifying blood and / or protecting heart and brain and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition with effects of purifying blood and / or protecting heart and brain and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 55-65 parts of radix salviae miltiorrhizae, 10-20 parts of radix notoginseng, 15-25 parts of green tea, 1-10 parts of radix glycyrrhizae and 1-6 parts of flos rosae rugosae. The preparation method comprises the following steps: extracting a green tea extract by using supercritical carbon dioxide, extracting a radix salviae miltiorrhizae and radix notoginseng extract by using ethanol aqueous solutions with different concentrations, preparing a licorice root and rose flower extract by using an enzymolysis method, mixing the green tea extract, the radix salviae miltiorrhizae and radix notoginseng extract and the licorice root and rose flower extract, and preparing the licorice root and rose flower extract. According to the traditional Chinese medicine composition disclosed by the invention, a plurality of components synergistically play a role, and the traditional Chinese medicine composition has the effects of purifying blood and / or protecting heart and brain.

Description

Technical Field

[0001] The invention belongs to the technical field of health care products, and in particular relates to a Chinese medicine composition having the functions of purifying blood and / or protecting heart and brain and an application thereof. Background Art

[0002] Danshen, scientifically known as Salviamiltiorrhiza, is a plant of the Lamiaceae family. It has a long history of application in traditional Chinese medicine and is a commonly used herbal medicine for promoting blood circulation and removing blood stasis. Chinese medicinal effects: Danshen has the effects of promoting blood circulation and removing blood stasis, relieving pain through menstruation, and clearing the heart and removing troubles. It is often used to treat cardiovascular diseases such as coronary heart disease and angina pectoris, as well as gynecological diseases such as irregular menstruation. Modern research also shows that Danshen has antioxidant, anti-inflammatory, and heart and blood vessel protection effects.

[0003] Panax notoginseng, also known as Tianqi, is a rare Chinese herbal medicine, mainly produced in Yunnan, China. Chinese medicinal effects: Panax notoginseng is known for its effects of promoting blood circulation, removing blood stasis, stopping bleeding and relieving pain. It is widely used for various bleeding symptoms and congestion diseases, such as traumatic bleeding, vomiting blood, blood in the stool, and injuries from falls. At the same time, Panax notoginseng also helps regulate blood pressure, enhance immunity and improve blood circulation.

[0004] Green tea is a type of tea that has not been fermented and retains more natural ingredients, such as tea polyphenols, caffeine, vitamin C, etc. Chinese medicine effect: In Chinese medicine theory, green tea is cool in nature and has the effects of clearing away heat and detoxifying, refreshing the mind, promoting the production of body fluids and quenching thirst, and reducing fat and weight. The antioxidants in green tea also show positive effects in preventing cardiovascular diseases, fighting cancer, and anti-aging.

[0005] Licorice, scientifically known as Glycyrrhizauralensis, is a plant of the Leguminosae family. Its roots and rhizomes are used as medicine and are one of the most widely used medicinal materials in traditional Chinese medicine. Chinese medicinal effects: Licorice is sweet, neutral in nature, and enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the middle and replenishing qi, moistening the lungs and relieving coughs, relieving acute pain, and clearing away heat and detoxifying. It is often used to blend other medicines and is known as the "national elder". It can reduce the toxicity of drugs and enhance their efficacy.

[0006] Roses mainly refer to medicinal roses, such as Rosarugosa, whose buds or newly opened flowers are used as medicine. Effects of Chinese medicine: Roses are mainly used in Chinese medicine to regulate qi and relieve depression, promote blood circulation and relieve blood stasis, regulate menstruation and relieve pain. They have a good effect on symptoms such as chest tightness, stomach pain, and irregular menstruation caused by liver-stomach disharmony. In addition, roses also have the effects of beautifying the skin, calming the nerves and helping sleep.

[0007] These medicinal materials have their own characteristics. This application attempts to combine multiple ingredients such as salvia miltiorrhiza, Panax notoginseng, green tea, licorice and rose through a specific extraction method in order to achieve better health care effects. Summary of the invention

[0008] The purpose of the present invention is to provide a Chinese medicine composition having the function of purifying blood and / or protecting heart and brain and its application.

[0009] In order to achieve the above object, the present invention provides the following technical solutions: A Chinese medicinal composition with blood purifying and / or heart and brain protecting effects comprises the following components in parts by weight: 55-65 parts of salvia miltiorrhiza, 10-20 parts of notoginseng, 15-25 parts of green tea, 1-10 parts of liquorice and 1-6 parts of rose.

[0010] Furthermore, the method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 30-50 kg / h, an extraction temperature of 40-55° C., an extraction pressure of 25-35 MPa, and an extraction time of 2-3 h to obtain a green tea extract; (2) After mixing Danshen and Panax notoginseng, crush them to obtain a mixed powder of Danshen and Panax notoginseng, and reflux extract them for 100-150 minutes with an ethanol aqueous solution with a volume concentration of 55-60% and a mass of 16-18 times that of the mixed powder of Danshen and Panax notoginseng to obtain a first extract and a first extract residue; adding an ethanol aqueous solution with a volume concentration of 65-70% and a mass of 12-15 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding an ethanol aqueous solution with a volume concentration of 75-80% and a mass of 12-15 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying them in sequence to obtain a Danshen and Panax notoginseng extract.

[0011] (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass of 10-12 times the mass of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 50-60 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass of 12-15 times the mass of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

[0012] Furthermore, the step (1) further comprises: firstly performing a first stage separation, the separation temperature is 40-45°C, and the separation pressure is 9-10MPa; and finally performing a second stage separation, the separation temperature is 30-35°C, and the separation pressure is 4-7MPa; Further, the green tea is crushed to 50-100 meshes.

[0013] Furthermore, after mixing the salvia miltiorrhiza and the panax notoginseng, the mixture is crushed into 30-80 meshes.

[0014] Furthermore, the temperature of the dialysis water A is 40-50°C.

[0015] Furthermore, the temperature of the dialysis water B is 90-93°C.

[0016] Further, pectinase accounts for 0.3-0.4% of the mass of the liquorice rose flower powder.

[0017] Further, the cellulase accounts for 0.1-0.2% of the mass of the liquorice rose flower powder.

[0018] Furthermore, ultra-high temperature instantaneous sterilization is carried out at a temperature of 135-137°C and a time of 25-30 seconds.

[0019] The present invention also provides the use of the traditional Chinese medicine composition in preparing health tea with blood purification function and / or heart and brain protection function.

[0020] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows: the present invention uses salvia miltiorrhiza, panax notoginseng, green tea, licorice and rose as raw materials, and is prepared by a specific preparation method, namely, extracting green tea extract by supercritical carbon dioxide extraction, extracting salvia miltiorrhiza and panax notoginseng extract by using ethanol aqueous solution of different concentrations, and preparing licorice and rose extract by enzymatic hydrolysis, and mixing the green tea extract, salvia miltiorrhiza and panax notoginseng extract and licorice and rose extract to obtain a traditional Chinese medicine composition. The traditional Chinese medicine composition of the present invention has the effect of purifying blood and / or protecting the heart and brain through the synergistic effect of multiple components. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] Example 1 This embodiment provides a Chinese medicine composition with blood purifying and / or heart and brain protecting effects, comprising the following components in parts by weight: 60 parts of salvia miltiorrhiza, 15 parts of Panax notoginseng, 21 parts of green tea, 7 parts of liquorice and 3 parts of rose.

[0023] The method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 40 kg / h, an extraction temperature of 50°C, an extraction pressure of 30 MPa, and an extraction time of 2.5 h to obtain a green tea extract; (2) After mixing Danshen and Panax notoginseng, crush them to obtain a mixed powder of Danshen and Panax notoginseng, and reflux extract them for 120 minutes with an ethanol aqueous solution with a volume concentration of 57% and a mass of 17 times that of the mixed powder of Danshen and Panax notoginseng to obtain a first extract and a first extract residue; adding an ethanol aqueous solution with a volume concentration of 68% and a mass of 14 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding an ethanol aqueous solution with a volume concentration of 78% and a mass of 14 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying them in sequence to obtain a Danshen and Panax notoginseng extract.

[0024] (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass 11 times that of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 55 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass 14 times that of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

[0025] The step (1) further comprises: firstly performing a first stage separation at a separation temperature of 42° C. and a separation pressure of 9.5 MPa; and finally performing a second stage separation at a separation temperature of 32° C. and a separation pressure of 5 MPa; Grind the green tea into 50-100 mesh.

[0026] Mix Salvia miltiorrhiza and Panax notoginseng, and crush them into 30-80 mesh.

[0027] The temperature of dialysis water A is 45°C.

[0028] The temperature of dialysis water B is 92°C.

[0029] Pectinase accounts for 0.35% of the mass of Licorice Rose Flower Powder.

[0030] Cellulase accounts for 0.14% of the mass of liquorice rose flower powder.

[0031] Ultra-high temperature instantaneous sterilization, the sterilization temperature is 136℃ and the time is 27 seconds.

[0032] Example 2 This embodiment provides a Chinese medicine composition with blood purifying and / or heart and brain protecting effects, comprising the following components in parts by weight: 55 parts of salvia miltiorrhiza, 10 parts of Panax notoginseng, 15 parts of green tea, 1 part of liquorice and 1 part of rose.

[0033] The method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 30 kg / h, an extraction temperature of 40°C, an extraction pressure of 25 MPa, and an extraction time of 2 h to obtain a green tea extract; (2) After mixing Danshen and Panax notoginseng, crush them to obtain a mixed powder of Danshen and Panax notoginseng, and reflux extract them for 100 minutes with an ethanol aqueous solution with a volume concentration of 55% and a mass that is 16 times that of the mixed powder of Danshen and Panax notoginseng to obtain a first extract and a first extract residue; adding an ethanol aqueous solution with a volume concentration of 65% and a mass that is 12 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding an ethanol aqueous solution with a volume concentration of 75% and a mass that is 12 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying them in sequence to obtain a Danshen and Panax notoginseng extract.

[0034] (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass that is 10 times the mass of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 50 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass that is 12 times the mass of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

[0035] The step (1) further comprises: firstly performing a first stage separation at a separation temperature of 40° C. and a separation pressure of 9 MPa; and finally performing a second stage separation at a separation temperature of 30° C. and a separation pressure of 4 MPa; Grind the green tea into 50-100 mesh.

[0036] Mix Salvia miltiorrhiza and Panax notoginseng, and crush them into 30-80 mesh.

[0037] The temperature of dialysis water A is 40℃.

[0038] The temperature of dialysis water B is 90°C.

[0039] Pectinase accounts for 0.3% of the mass of Licorice Rose Flower Powder.

[0040] Cellulase accounts for 0.1% of the mass of liquorice rose flower powder.

[0041] Ultra-high temperature instantaneous sterilization, the sterilization temperature is 135℃ and the time is 25 seconds.

[0042] Example 3 This embodiment provides a Chinese medicine composition with blood purifying and / or heart and brain protecting effects, comprising the following components in parts by weight: 65 parts of salvia miltiorrhiza, 20 parts of Panax notoginseng, 25 parts of green tea, 10 parts of liquorice and 6 parts of rose.

[0043] The method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 50 kg / h, an extraction temperature of 55°C, an extraction pressure of 35 MPa, and an extraction time of 3 h to obtain a green tea extract; (2) After mixing Danshen and Panax notoginseng, crush them to obtain a mixed powder of Danshen and Panax notoginseng, and reflux extract them for 150 minutes with an ethanol aqueous solution with a volume concentration of 60% and a mass that is 18 times that of the mixed powder of Danshen and Panax notoginseng to obtain a first extract and a first extract residue; adding an ethanol aqueous solution with a volume concentration of 70% and a mass that is 15 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding an ethanol aqueous solution with a volume concentration of 80% and a mass that is 15 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying them in sequence to obtain a Danshen and Panax notoginseng extract.

[0044] (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass 12 times that of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 60 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass 15 times that of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

[0045] The step (1) further comprises: firstly performing a first stage separation at a separation temperature of 45°C and a separation pressure of 10 MPa; and finally performing a second stage separation at a separation temperature of 35°C and a separation pressure of 7 MPa; Grind the green tea into 50-100 mesh.

[0046] Mix Salvia miltiorrhiza and Panax notoginseng, and crush them into 30-80 mesh.

[0047] The temperature of dialysis water A is 50°C.

[0048] The temperature of dialysis water B is 93°C.

[0049] Pectinase accounts for 0.4% of the mass of Licorice rose flower powder.

[0050] Cellulase accounts for 0.2% of the mass of liquorice rose flower powder.

[0051] Ultra-high temperature instantaneous sterilization, the sterilization temperature is 137°C and the time is 30 seconds.

[0052] Comparative Example 1 The difference between this comparative example and Example 1 is that the number of components is different.

[0053] A Chinese medicinal composition with blood purifying and / or heart and brain protecting effects comprises the following components in parts by mass: 40 parts of salvia miltiorrhiza, 15 parts of notoginseng, 21 parts of green tea, 17 parts of liquorice and 13 parts of rose.

[0054] The method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 40 kg / h, an extraction temperature of 50°C, an extraction pressure of 30 MPa, and an extraction time of 2-3 h to obtain a green tea extract; (2) After mixing Danshen and Panax notoginseng, crush them to obtain a mixed powder of Danshen and Panax notoginseng, and reflux extract them for 120 minutes with an ethanol aqueous solution with a volume concentration of 57% and a mass of 17 times that of the mixed powder of Danshen and Panax notoginseng to obtain a first extract and a first extract residue; adding an ethanol aqueous solution with a volume concentration of 68% and a mass of 14 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding an ethanol aqueous solution with a volume concentration of 78% and a mass of 14 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying them in sequence to obtain a Danshen and Panax notoginseng extract.

[0055] (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass 11 times that of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 55 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass 14 times that of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

[0056] The step (1) further comprises: firstly performing a first stage separation at a separation temperature of 42° C. and a separation pressure of 9.5 MPa; and finally performing a second stage separation at a separation temperature of 32° C. and a separation pressure of 5 MPa; Grind the green tea into 50-100 mesh.

[0057] Mix Salvia miltiorrhiza and Panax notoginseng, and crush them into 30-80 mesh.

[0058] The temperature of dialysis water A is 45°C.

[0059] The temperature of dialysis water B is 92°C.

[0060] Pectinase accounts for 0.35% of the mass of Licorice Rose Flower Powder.

[0061] Cellulase accounts for 0.14% of the mass of liquorice rose flower powder.

[0062] Ultra-high temperature instantaneous sterilization, the sterilization temperature is 136℃ and the time is 27 seconds.

[0063] Comparative Example 2 The difference between this comparative example and Example 1 is that the number of components is different.

[0064] A Chinese medicinal composition with blood purifying and / or heart and brain protecting effects comprises the following components in parts by mass: 60 parts of salvia miltiorrhiza, 5 parts of panax notoginseng, 11 parts of green tea, 17 parts of liquorice and 13 parts of rose.

[0065] The method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 40 kg / h, an extraction temperature of 50°C, an extraction pressure of 30 MPa, and an extraction time of 2 h to obtain a green tea extract; (2) After mixing Danshen and Panax notoginseng, crush them to obtain a mixed powder of Danshen and Panax notoginseng, and reflux extract them for 120 minutes with an ethanol aqueous solution with a volume concentration of 57% and a mass of 17 times that of the mixed powder of Danshen and Panax notoginseng to obtain a first extract and a first extract residue; adding an ethanol aqueous solution with a volume concentration of 68% and a mass of 14 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding an ethanol aqueous solution with a volume concentration of 78% and a mass of 14 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying them in sequence to obtain a Danshen and Panax notoginseng extract.

[0066] (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass 11 times that of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 55 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass 14 times that of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

[0067] The step (1) further comprises: firstly performing a first stage separation at a separation temperature of 42° C. and a separation pressure of 9.5 MPa; and finally performing a second stage separation at a separation temperature of 32° C. and a separation pressure of 5 MPa; Grind the green tea into 50-100 mesh.

[0068] Mix Salvia miltiorrhiza and Panax notoginseng, and crush them into 30-80 mesh.

[0069] The temperature of dialysis water A is 45°C.

[0070] The temperature of dialysis water B is 92°C.

[0071] Pectinase accounts for 0.35% of the mass of Licorice Rose Flower Powder.

[0072] Cellulase accounts for 0.14% of the mass of liquorice rose flower powder.

[0073] Ultra-high temperature instantaneous sterilization, the sterilization temperature is 136℃ and the time is 27 seconds.

[0074] Comparative Example 3 The difference between this comparative example and Example 1 is that the number of components is different.

[0075] A Chinese medicinal composition with blood purifying and / or heart and brain protecting effects comprises the following components in parts by mass: 70 parts of salvia miltiorrhiza, 5 parts of notoginseng, 11 parts of green tea, 7 parts of liquorice and 13 parts of rose.

[0076] The method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 40 kg / h, an extraction temperature of 50°C, an extraction pressure of 30 MPa, and an extraction time of 2.5 h to obtain a green tea extract; (2) After mixing Danshen and Panax notoginseng, crush them to obtain a mixed powder of Danshen and Panax notoginseng, and reflux extract them for 120 minutes with an ethanol aqueous solution with a volume concentration of 57% and a mass of 17 times that of the mixed powder of Danshen and Panax notoginseng to obtain a first extract and a first extract residue; adding an ethanol aqueous solution with a volume concentration of 68% and a mass of 14 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding an ethanol aqueous solution with a volume concentration of 78% and a mass of 14 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying them in sequence to obtain a Danshen and Panax notoginseng extract.

[0077] (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass 11 times that of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 55 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass 14 times that of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

[0078] The step (1) further comprises: firstly performing a first stage separation at a separation temperature of 42° C. and a separation pressure of 9.5 MPa; and finally performing a second stage separation at a separation temperature of 32° C. and a separation pressure of 5 MPa; Grind the green tea into 50-100 mesh.

[0079] Mix Salvia miltiorrhiza and Panax notoginseng, and crush them into 30-80 mesh.

[0080] The temperature of dialysis water A is 45°C.

[0081] The temperature of dialysis water B is 92°C.

[0082] Pectinase accounts for 0.35% of the mass of Licorice Rose Flower Powder.

[0083] Cellulase accounts for 0.14% of the mass of liquorice rose flower powder.

[0084] Ultra-high temperature instantaneous sterilization, the sterilization temperature is 136℃ and the time is 27 seconds.

[0085] Performance Testing The performance tests were performed on the Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-3.

[0086] Patients diagnosed with hyperlipidemia were selected as volunteers, whose blood lipids had not been well controlled for many years. They were divided into 6 groups, each with 20 people, and given the Chinese medicine composition of Examples 1-3 of the present invention and Comparative Examples 1-4, twice a day, 0.5 g each time with water, for 90 consecutive days, and the clinical efficacy was observed.

[0087] Blood lipid determination criteria: Significantly effective: blood lipid test reaches any of the following Total cholesterol (TC) drops to within the normal range or decreases by ≥20%; Triglycerides (TG) dropped to within the normal range or decreased by ≥20%; Low-density lipoprotein (LDL-C) drops to within the normal range or decreases by ≥20%; High-density lipoprotein (HDL-C) rises to within the normal range or rises ≥0.26 mmol / L; Effective: Blood lipid test reaches any of the following Total cholesterol (TC) decreased within 10%~20%; Triglyceride (TG) decreased within 20%~40%; Low-density lipoprotein (LDL-C) decreased within 10%~20%; The high-density lipoprotein (HDL-C) rises in the range of 0.104 to 0.26 mmol / L; Ineffective: No change in blood lipid test results compared to before taking the medicine or those who do not meet the above standards.

[0088] Table 1 Performance test results

[0089] The results show that the Chinese medicine compositions prepared in Examples 1-3 of the present invention can improve blood lipid status. Comparative Examples 1-3 show that the effect decreases when the ratio of the components is changed.

[0090] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition having the function of purifying blood and / or protecting heart and brain, characterized in that: The invention comprises the following components in parts by weight: 55-65 parts of salvia miltiorrhiza, 10-20 parts of panax notoginseng, 15-25 parts of green tea, 1-10 parts of liquorice and 1-6 parts of rose; The method for preparing the Chinese medicine composition having the function of purifying blood and / or protecting heart and brain comprises the following steps: (1) Grinding green tea to obtain green tea powder, subjecting the green tea powder to supercritical CO2 extraction, with a CO2 flow rate of 30-50 kg / h, an extraction temperature of 40-55° C., an extraction pressure of 25-35 MPa, and an extraction time of 2-3 h to obtain a green tea extract; (2) Mixing Danshen and Panax notoginseng, crushing to obtain Danshen Panax notoginseng mixed powder, refluxing and extracting for 100-150 minutes with ethanol aqueous solution with a volume concentration of 55-60% and a mass of 16-18 times that of the Danshen Panax notoginseng mixed powder, to obtain a first extract and a first extract residue; adding ethanol aqueous solution with a volume concentration of 65-70% and a mass of 12-15 times that of the first extract residue to the first extract residue for secondary extraction to obtain a second extract and a second extract residue; adding ethanol aqueous solution with a volume concentration of 75-80% and a mass of 12-15 times that of the second extract residue to the second extract residue for a third extraction to obtain a third extract and a third extract residue; combining the first extract, the second extract and the third extract to obtain an extract, and concentrating and drying in sequence to obtain a Danshen Panax notoginseng extract; (3) Mix the licorice rose and crush them into 50-80 meshes to obtain licorice rose powder, put the licorice rose powder into a traditional Chinese medicine extraction tank, then add dialysis water A with a mass of 10-12 times the mass of the licorice rose powder, turn on the stirring device in the extraction tank, add cellulase and pectinase, and after enzymolysis for 50-60 minutes, release the enzymolysis extract, and finally add dialysis water B with a mass of 12-15 times the mass of the licorice rose powder for high-temperature extraction; combine the two extracts, use ultra-high temperature instant sterilization, and obtain the licorice rose extract after spray drying; (4) Green tea extract, salvia miltiorrhiza and Panax notoginseng extract, and liquorice and rose flower extract are mixed to obtain a Chinese medicine composition having blood purification effect and / or heart and brain protection effect.

2. The Chinese medicinal composition having blood purification effect and / or heart and brain protection effect according to claim 1, characterized in that: The step (1) further comprises: firstly performing a first stage separation, at a separation temperature of 40-45° C. and a separation pressure of 9-10 MPa; and finally performing a second stage separation, at a separation temperature of 30-35° C. and a separation pressure of 4-7 MPa.

3. The Chinese medicinal composition having blood purification effect and / or heart and brain protection effect according to claim 1, characterized in that: Grind the green tea into 50-100 mesh.

4. The Chinese medicinal composition having blood purification effect and / or heart and brain protection effect according to claim 1, characterized in that: Mix Salvia miltiorrhiza and Panax notoginseng, and crush them into 30-80 mesh.

5. The Chinese medicinal composition having blood purification effect and / or heart and brain protection effect according to claim 1, characterized in that: The temperature of dialysis water A is 40-50℃.

6. The Chinese medicinal composition having blood purification effect and / or heart and brain protection effect according to claim 1, characterized in that: The temperature of dialysis water B is 90-93℃.

7. The Chinese medicinal composition having the effect of purifying blood and / or protecting heart and brain according to claim 1, characterized in that: Pectinase accounts for 0.3-0.4% of the mass of liquorice rose flower powder.

8. The Chinese medicinal composition having blood purification effect and / or heart and brain protection effect according to claim 1, characterized in that: Cellulase accounts for 0.1-0.2% of the mass of liquorice rose flower powder.

9. The Chinese medicinal composition having blood purification effect and / or heart and brain protection effect according to claim 1, characterized in that: Ultra-high temperature instantaneous sterilization, the sterilization temperature is 135-137℃, and the time is 25-30 seconds.

10. Use of the Chinese medicine composition according to any one of claims 1 to 9 in the preparation of health products for purifying blood and / or protecting heart and brain.

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