Composition containing mineral substances and liquid preparation using same

Abstract

The invention provides a mineral substance-containing composition and a liquid preparation using the same, the mineral substance-containing composition comprises calcium salt, magnesium salt and an aqueous solvent, the calcium salt comprises insoluble calcium salt and soluble calcium salt, the solubility of the insoluble calcium salt is less than 1g / 100mL, and the solubility of the soluble calcium salt is greater than 3g / 100mL. The mass ratio of the insoluble calcium salt to the soluble calcium salt to the magnesium salt is (3-15): (1-5.5): (1-11); the mass ratio of the insoluble calcium salt to the soluble calcium salt is (1.6-7): 1; preferably, the aqueous solvent is water. The composition containing the mineral substances is moderate in viscosity, good in fluidity, good in solution stability and capable of containing high-content mineral substance components.

Description

Technical Field

[0001] This patent belongs to the field of nutrient supplements, and specifically, relates to a composition containing minerals and a liquid preparation using the same. Background Art

[0002] Calcium is an essential mineral for the human body. Calcium not only constitutes the human skeleton, but also plays an irreplaceable and important role in the transmission of stress impulses in the nerves and muscles, maintenance of heart rhythm, maintaining the integrity and permeability of cell membranes, maintaining the acid-base balance in the body, and blood coagulation. Calcium can also reduce the permeability of capillaries, prevent exudation, and control inflammation and edema.

[0003] Magnesium plays a number of important roles in maintaining normal physiological functions. It is an activator of many enzymes and is involved in protein synthesis, regulation of muscle and nerve function, and energy metabolism. Magnesium also helps maintain heart rhythm, bone health, and may be beneficial for blood sugar control and blood pressure management. In addition, magnesium is essential for the normal functioning of the immune system.

[0004] Given the modern diet and the loss of nutrients that may result from food processing, it is sometimes difficult for the human body to obtain enough minerals from the daily diet. In order to fill this gap and ensure that the human body obtains comprehensive and balanced mineral nutrition, nutritional supplements have emerged as an effective auxiliary means.

[0005] However, when calcium and magnesium salts are taken alone through nutritional supplements, it is not only inconvenient in practice, but also not the best strategy from the perspective of physiological absorption. This is because the absorption of nutrients by the human body is often affected by many factors, including the interaction between nutrients. The joint intake of calcium and magnesium salts can form a more synergistic nutritional system, thereby optimizing their absorption efficiency and utilization effect in the human body. Summary of the invention

[0006] The object of the present invention is to seek a composition containing minerals and a liquid preparation using the same, wherein the composition containing minerals has good fluidity and can accommodate a high content of mineral components.

[0007] According to one aspect of the present invention, a composition containing minerals is provided, comprising calcium salt, magnesium salt, and aqueous solvent, wherein the calcium salt comprises insoluble calcium salt and soluble calcium salt, the solubility of insoluble calcium salt is less than 1g / 100mL, and the solubility of soluble calcium salt is greater than 3g / 100mL; the mass ratio of insoluble calcium salt, soluble calcium salt, and magnesium salt is 3-15:1-5.5:1-11; the mass ratio of insoluble calcium salt to soluble calcium salt is 1.6-7:1. Preferably, the aqueous solvent is water. For example, the mass ratio of insoluble calcium salt, soluble calcium salt, and magnesium salt is 3:1:1, 4:1.2:2, 5:1.5:3, 6:1.8:4, 7:2:5, 8:2.2:6.5, 9:2.5:7, 10:3:7.5, 11:3.5:8, 12:4:8.5, 13:4.5:9, 14:5:10, 15:5.5:11, etc. The mass ratio of insoluble calcium salt to soluble calcium salt is 3:1:1, 4:1.2:2, 5:1.5:3, 6:1.8:4, 7:2:5, 8:2.2:6.5, 9:2.5:7, 10:3:7.5, 11:3.5:8, 12:4:8.5, 13:4.5:9, 14:5:10, 15:5.5:11, etc. The mass ratio of soluble calcium salt is 1.6:1, 1.9:1, 2:1, 2.2:1, 2.6:1, 2.9:1, 3:1, 3.2:1, 3.6:1, 3.9:1, 4:1, 4.2:1, 4.6:1, 4.9:1, 5:1, 5.2:1, 5.6:1, 5.9:1, 6:1, 6.2:1, 6.6:1, 6.9:1, 7:1 and the like.

[0008] By adjusting the mass ratio of soluble calcium salt, insoluble calcium salt and magnesium salt in the composition, the solution stability of the composition can be improved while ensuring a high mineral content in the composition. The applicant has found through a series of experiments and scientific research that when in a liquid dispersion system, magnesium salt and insoluble calcium salt will undergo a specific reaction to form a colloid-like structure, resulting in changes in the physical properties of the liquid dispersion system, which is specifically manifested as a significant increase in the viscosity of the liquid dispersion system. In extreme cases, the solution will even appear gel-like and lose fluidity. This change not only affects the edible taste of the composition containing minerals, causing problems such as difficulty in swallowing, but also makes it difficult for the nutrients in the composition to be ingested by the consumer in a conventional manner. However, if the magnesium salt and insoluble calcium salt in the liquid composition are reduced in order to ensure that the viscosity of the composition containing minerals is within an appropriate range, it is difficult to provide the daily nutrient intake required by the human body. Therefore, the applicant introduced a soluble calcium salt into a composition containing a sparingly soluble calcium salt and a magnesium salt, and adjusted the mass ratio of the sparingly soluble calcium salt, the soluble calcium salt and the magnesium salt, so that the magnesium salt reacted with the soluble calcium salt first, thereby reducing the probability of the magnesium salt reacting with the sparingly soluble calcium salt. On the premise of increasing the mineral content of the composition, the applicant can effectively improve the viscosity of the system caused by the compounding of the sparingly soluble calcium salt and the magnesium salt, improve the fluidity of the system, enhance the stability of the solution, meet the nutrient supplementation needs of the human body, and provide a new idea for the formulation optimization of nutritional supplements.

[0009] Preferably, the poorly soluble calcium salt includes at least one of calcium citrate, calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, and calcium citrate malate.

[0010] Preferably, the magnesium salt includes at least one of magnesium gluconate, magnesium L-threonate, magnesium citrate, magnesium chloride, and magnesium glycinate.

[0011] Preferably, the soluble calcium salt includes at least one of calcium gluconate, calcium L-lactate, calcium lactate, calcium chloride and calcium acetate.

[0012] Preferably, metal salts and / or selenium salts are also included, and the metal salts include at least one of iron salts, zinc salts, copper salts, and manganese salts. By adding metal salts and selenium salts to the composition containing minerals, it is beneficial to supplement the nutrients required by the human body, maintain the health of the body, promote metabolism, improve physical and mental health, and maintain the storage stability and long-term activity of vitamins.

[0013] Preferably, the total weight of the metal salt and the selenium salt in the composition is not higher than 2.5wt%. For example, the total weight of the metal salt and the selenium salt in the composition is 0.2wt%, 0.5wt%, 0.8wt%, 1wt%, 1.2wt%, 1.5wt%, 1.8wt%, 2.5wt%, 2.2wt%, 2.5wt%, etc. The content of the metal salt and the selenium salt is further regulated to meet the human body's demand for metal elements and / or selenium elements, reduce the possibility of excessive intake of minerals and metal elements, and improve the storage stability of the composition containing minerals.

[0014] Preferably, the total weight percentage of calcium salt in the composition containing minerals is 5-21 wt %. For example, the total weight percentage of calcium salt in the composition containing minerals is 5 wt %, 7 wt %, 10 wt %, 13 wt %, 15 wt %, 17 wt %, 20 wt %, 21 wt %, etc.

[0015] Preferably, the mass proportion of magnesium salt in the composition containing minerals is 1-12wt%. For example, the mass proportion of magnesium salt in the composition containing minerals is 1wt%, 2wt%, 3wt%, 4wt%, 5wt%, 6wt%, 7wt%, 8wt%, 9wt%, 10wt%, 11wt%, 12wt%, etc.

[0016] According to another aspect of the present invention, a liquid preparation is provided, comprising an oily solvent, vitamin D, an emulsifier and the above-mentioned mineral-containing composition.

[0017] By introducing vitamin D and a composition containing minerals into a liquid preparation, the absorption of nutrients in the mineral supplement solution by the human body can be improved. Vitamin D is known as the "sunshine vitamin" and plays a key role in promoting calcium absorption. Specifically, vitamin D can activate calcium-binding proteins in the intestine, thereby greatly improving the efficiency of calcium ions being absorbed from the digestive system into the blood. At the same time, magnesium salts in the mineral supplement solution can promote the conversion of vitamin D into an active form, thereby indirectly enhancing the absorption and utilization of calcium. However, it is worth noting that the molecular structure of vitamin D makes it prone to structural changes in an environment containing a large amount of calcium ions. Therefore, in a high calcium environment, vitamin D is prone to degradation, thereby affecting the biological activity of vitamin D in a liquid preparation. Therefore, by using the above-mentioned composition containing minerals, the mass ratio of insoluble calcium salts, soluble calcium salts and magnesium salts in the liquid preparation is regulated, which can not only enable calcium salts, magnesium salts and vitamin D to coexist at a higher concentration, improve the activity and storage stability of vitamin D in a high calcium environment, but also effectively improve the supplement effect of nutrients, reduce the number of daily doses of consumers, thereby greatly simplifying the taking process. Secondly, vitamin D belongs to oil-soluble vitamins, and the above-mentioned composition containing minerals adopts aqueous solvents. If vitamin D is directly introduced into the composition containing minerals, it will inevitably cause stratification due to the principle that oil and water are immiscible, thereby affecting the uniformity and stability of the liquid preparation. Therefore, it is also necessary to use an oily solvent to dissolve vitamin D, and use an emulsifier to cleverly combine the oily component with the aqueous component to promote the fusion of the oil and water phases, effectively prevent stratification, and form a stable liquid preparation. The liquid preparation provided by the present invention uses the above-mentioned composition containing minerals and vitamin D as active ingredients, which is beneficial to maintaining the normal growth and development of the body of the user, and achieves the effect of promoting metabolism and enhancing the body's immunity. Compared with commercially available mineral supplements in liquid dosage forms, the calcium content and magnesium content of the above-mentioned liquid preparation are higher, which can reduce the number of daily doses of the consumer, simplify the taking process, improve the long-term compliance of the consumer, and improve the supplement effect of nutrients.

[0018] Preferably, the emulsifier includes at least one of gum arabic, sodium starch octenyl succinate, polyglycerol fatty acid ester, and sucrose fatty acid ester.

[0019] Preferably, the oily solvent includes at least one of vegetable oil and animal oil. Preferably, the vegetable oil includes at least one of soybean oil, rapeseed oil, olive oil, walnut oil, peanut oil, sunflower oil and corn oil.

[0020] Preferably, calculated by weight, the liquid preparation contains 0.5 to 1 part of an oily solvent, 0.00001 to 0.0001 part of vitamin D, 1 to 10 parts of an emulsifier, 3 to 15 parts of a poorly soluble calcium salt, 1 to 5.5 parts of a soluble calcium salt, and 1 to 11 parts of a magnesium salt.

[0021] Preferably, the mass ratio of the poorly soluble calcium salt to the soluble calcium salt is 1.9-7:1.

[0022] Preferably, the liquid preparation further comprises at least one of a thickener, a filler, an acidity regulator, a flavor, a pigment, and a nutrient. According to actual application requirements, at least one of a thickener, a filler, an acidity regulator, a flavor, a pigment, and a nutrient can be introduced into the liquid preparation, and the above-mentioned auxiliary agents and / or nutrients have little effect on the viscosity of the liquid preparation and the storage stability of vitamin D.

[0023] Preferably, the nutritional ingredients include oil-soluble nutritional ingredients and water-soluble nutritional ingredients.

[0024] Preferably, the nutritional ingredients include at least one of vitamins, amino acids, proteins, polyphenols, glycosides, lipids, polysaccharides, ω-polyunsaturated fatty acids, L-carnitine, enzymes, and coenzyme Q10.

[0025] Preferably, the thickener includes at least one of xanthan gum, pectin, guar gum, carrageenan, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose and povidone K.

[0026] Preferably, the filler comprises at least one of xylitol, erythritol, D-mannitol, sorbitol, maltitol, isomalt, maltodextrin, dextrin, galacto-oligosaccharide and isomalt-oligosaccharide.

[0027] Preferably, the acidity regulator comprises at least one of citric acid, malic acid, tartaric acid, lactic acid and fumaric acid.

[0028] Preferably, calculated by weight, the liquid preparation further contains 0.01 to 1 parts of a thickener, 15 to 25 parts of a filler, 0.5 to 3 parts of an acidity regulator, 0.01 to 0.5 parts of a flavor, 0.001 to 0.25 parts of a pigment, and 0.01 to 5 parts of a nutrient.

[0029] Preferably, the method for preparing a liquid preparation includes the following operations: S1. Mixing vitamin D with an oily solvent, and then heating to 75-85° C. to obtain a first reaction liquid; S2. Preparing an emulsifier and an aqueous solvent into a second reaction liquid, then mixing the first reaction liquid with the second reaction liquid, and forming an emulsion after dispersion treatment; S3. Mixing a calcium salt and a magnesium salt with the mixed liquid, and obtaining a liquid preparation after dispersion treatment.

[0030] Preferably, in S1, it further includes introducing oil-soluble nutrients into the first reaction liquid. The specific operation of S1 includes mixing vitamin D, an oily solvent, and an oil-soluble nutrient, and then heating to 75-85° C. to obtain the first reaction liquid.

[0031] Preferably, in S1, the temperature is maintained at 75 to 85°C for 5 to 20 minutes.

[0032] Preferably, in S2, at least one of a thickener, a filler, and a water-soluble nutrient component is introduced into the second reaction liquid. The specific operation of S2 includes configuring the emulsifier, the solvent, the thickener, the filler, and the water-soluble nutrient component into the second reaction liquid, and then mixing the first reaction liquid with the second reaction liquid to form an emulsion after dispersion treatment.

[0033] Preferably, in the dispersion process of S2, the rotation speed is 6000 to 12000 rpm, and the mixing time is 2 to 7 minutes.

[0034] Preferably, in S3, at least one of an acidity regulator, an essence, and a pigment is introduced into the emulsion. The specific operation of S3 includes mixing calcium salt, magnesium salt, acidity regulator, essence, and pigment with the mixed solution, and obtaining a liquid preparation after dispersion treatment.

[0035] Preferably, in the dispersion process of S3, the rotation speed is 3000 to 8000 rpm, and the mixing time is 3 to 8 minutes.

[0036] Preferably, the method for preparing the liquid preparation further comprises sterilizing the liquid preparation.

[0037] Preferably, the sterilization is carried out by pasteurization.

[0038] Preferably, the treatment temperature of the pasteurization method is 75-100° C., and the sterilization time is 10-60 minutes.

[0039] According to another aspect of the present invention, there is provided a use of the above composition or the above liquid preparation in food, medicine or cosmetics. Preferably, the food is a health food. DETAILED DESCRIPTION

[0040] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0041] Experiment I

[0042] 1. Preparation of a composition containing minerals

[0043] In this experiment, a composition containing minerals is prepared. The dispersion liquid uses a sparingly soluble calcium salt (calcium citrate) with a solubility of <1g / 100mL, a soluble calcium salt (calcium gluconate) with a solubility of >3g / 100mL as the calcium salt, magnesium gluconate as the magnesium salt, and purified water as the solvent.

[0044] In this experiment, the experimental groups were marked as experimental group 1-1, experimental group 1-2, experimental group 1-3, experimental group 1-4, experimental group 1-5, experimental group 1-6, experimental group 1-7, experimental group 1-8, experimental group 1-9, experimental group 1-10, control group 1, control group 2, control group 3, control group 4, and control group 5. The raw material compositions of the above experimental groups are shown in Table 1, and the raw material compositions selected in this experiment are all commercially available.

[0045] Table 1. Composition of raw materials used to prepare mineral supplement solution in Experiment I

[0046]

[0047]

[0048] The specific preparation method of the composition containing minerals comprises the following operations:

[0049] The calcium salt, magnesium salt and solvent are mixed at a speed of 5000 prm for 5 minutes to obtain a mineral composition, and the mineral supplement liquid is sterilized by pasteurization to obtain a finished product. The pasteurization temperature is 90°C and the sterilization time is 30 minutes.

[0050] 2. Test the above-mentioned mineral-containing composition

[0051] Test subjects: Test items and test methods of the mineral composition provided by experimental group 1-1 to experimental group 1-10 and control group 1 to 4:

[0052] (1) Viscosity: Refer to the test method of "Chinese Pharmacopoeia 2020 Edition Part IV General Viscosity Determination Method" and use a rotor type rotational viscometer to test the test objects. When the viscosity is ≤2000cP, it is considered to meet the requirements.

[0053] Test results: as shown in Table 2.

[0054] Table 2. Calculation and test results of the above test objects

[0055]

[0056]

[0057] Result analysis:

[0058] First, from the composition provided by Control Group 5, it can be found that when the poorly soluble calcium salt, magnesium salt and solvent coexist in a composition without a soluble calcium salt, the viscosity of the composition is too large, it becomes gel-like and loses fluidity.

[0059] According to the test results of the mineral-containing compositions provided by the comprehensive experimental groups 1-1 to 1-10 and the control groups 1 to 5 in the above table, the viscosity of the compositions of the experimental groups 1-1 to 1-10 is ≤2000cP, while the viscosity of the compositions of the control groups 1, 2, 4, and 5 is too large and presents a solidified state. This shows that when the mass ratio of the sparingly soluble calcium salt, the soluble calcium salt and the magnesium salt is 3 to 15: 1 to 5.5: 1 to 11, and the mass ratio of the sparingly soluble calcium salt to the soluble calcium salt is 1.6 to 7: 1, the viscosity of the system caused by the compounding of the sparingly soluble calcium salt and the magnesium salt can be effectively improved, the fluidity of the system can be improved, and the solution stability of the composition can be improved.

[0060] The compositions provided by control group 1, control group 5 and experimental group 1-1 to experimental group 1-4 are to adjust the mass ratio of insoluble calcium salt: soluble calcium salt under the premise of ensuring that the total content of calcium salt in the solvent remains unchanged, so as to explore the solution stability of the composition under the condition of consistent mineral content in the composition. According to the test results of control group 1, control group 5 and experimental group 1-1 to experimental group 1-4 in the above table, it can be found that the viscosity of the compositions of experimental group 1-1 to experimental group 1-4 is ≤2000cP, and the viscosity of the compositions provided by control group 1 and control group 5 is too large and presents a solidified state. This further illustrates that when the mass ratio of insoluble calcium salt, soluble calcium salt and magnesium salt is 3-15:1-5.5:1-11, the magnesium salt can react with the soluble calcium salt first, thereby reducing the probability of the magnesium salt reacting with the insoluble calcium salt, improving the fluidity of the system, and enhancing the solution stability of the composition. Among them, the content of soluble calcium salt in the composition of control group 1 is too small, which makes it difficult for the soluble calcium salt to effectively improve the solution viscosity of the composition, so the composition of control group 1 is in a solidified state.

[0061] The compositions provided by control group 2, control group 3, experimental group 1-2 and experimental group 1-5 to experimental group 1-7 are to regulate the mass fractions of the insoluble calcium salt and the soluble calcium salt under the premise of maintaining the mass ratio of the insoluble calcium salt to the soluble calcium salt unchanged. According to the test results of the above control group and experimental group in the above table, it can be found that the viscosity of the compositions provided by experimental group 1-2, experimental group 1-5 to experimental group 1-7 is ≤2000cP, and the viscosity of the composition provided by control group 2 is too large, showing a solidified state, that is, when the insoluble calcium salt in the composition is 18 parts by weight, the soluble calcium salt is 6 parts by weight, and the magnesium salt is 4 parts by weight, the viscosity of the composition is too large. Among them, although the solution viscosity of the composition provided by control group 3 is ≤2000cP, the composition does not contain magnesium salt, and the purpose of supplementing magnesium element cannot be achieved. Furthermore, the compositions provided by the control group 4, the experimental groups 1-6, and the experimental groups 1-8 to 1-10 are adjusted by adjusting the mass fraction of the magnesium salt while maintaining the mass ratio of the insoluble calcium salt to the soluble calcium salt. The test results shown in the above table show that the viscosities of the compositions provided by the experimental groups 1-6 and 1-8 to 1-10 are all ≤2000cP, while the viscosity of the composition provided by the control group 4 is too large and presents a solidified state. In summary, combined with the test results of control group 2, control group 4, experimental group 1-2 and experimental groups 1-5 to 1-10, it can be explained that when the mass ratio of the insoluble calcium salt, the soluble calcium salt and the magnesium salt is 3-15:1-5.5:1-11 and the mass ratio of the insoluble calcium salt to the soluble calcium salt is 1.6-7:1, the soluble calcium salt can improve the increase in the viscosity of the system caused by the reaction between the magnesium salt and the insoluble calcium salt, thereby improving the fluidity of the solution system of the composition. The reason is that the soluble calcium salt reacts with the magnesium salt first, thereby inhibiting the reaction between the insoluble calcium salt and the magnesium salt, thereby regulating the system fluidity of the composition.

[0062] Experiment II

[0063] 1. Preparation of a composition containing minerals

[0064] This example refers to Experimental Group 1-2 to prepare a composition containing minerals. The difference between Experimental Groups 1-11 to 1-22 and Experimental Group 1-2 is that the raw material composition is regulated according to Table 3. The remaining raw material ratios and preparation methods are strictly consistent with those of Experimental Group 1-2, especially the raw material composition not shown in Table 3 is strictly consistent with that of Experimental Group 1-2.

[0065] Table 3. Composition of raw materials used to prepare the composition in Experiment II

[0066]

[0067]

[0068] 2. The above composition was tested using the test method in Experiment I.

[0069] Test results: The viscosity of the compositions provided by experimental groups 1-11 to 1-22 was ≤2000 cP. This indicates that when the insoluble calcium salt is at least one of calcium citrate, calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, and calcium citrate malate; or when the magnesium salt is at least one of magnesium gluconate, magnesium L-threonate, magnesium citrate, magnesium chloride, and magnesium glycinate; or when the soluble calcium salt is at least one of calcium gluconate, calcium L-lactate, calcium lactate, calcium chloride, and calcium acetate, the obtained composition has a suitable viscosity.

[0070] Experiment III

[0071] 1. Preparation of a composition containing minerals

[0072] This example refers to Experimental Group 1-2 to prepare a composition containing minerals. The difference between this experimental group and Experimental Group 2-2 is that: according to the raw material composition provided in Table 4, metal salts and / or selenium salts are introduced to regulate the raw material composition of the composition. The remaining raw material ratios and preparation methods are strictly consistent with Experimental Group 1-2.

[0073] Table 4. Composition of raw materials used to prepare the composition in Experiment III

[0074]

[0075] 2. The above composition was tested using the test method in Experiment I.

[0076] Test results: The viscosity of the compositions provided by Experimental Groups 1-23 to 1-29 is ≤2000 cP. This indicates that when the composition further includes a metal salt and / or a selenium salt, and the metal salt includes at least one of magnesium, iron, zinc, copper, and manganese, other minerals have no effect on the viscosity of the system.

[0077] Experiment IV

[0078] 1. Preparation of liquid preparations

[0079] In this experiment, a liquid preparation is prepared. The liquid composition uses calcium citrate with a solubility of <1 g / 100 mL as the insoluble calcium salt, calcium gluconate with a solubility of >3 g / 100 mL as the soluble calcium salt, magnesium gluconate as the magnesium salt, and purified water as the solvent. The raw materials used in this experiment are all commercially available.

[0080] In this experiment, the experimental groups were marked as experimental group 2-1, experimental group 2-2, experimental group 2-3, experimental group 2-4, experimental group 2-5, experimental group 2-6, experimental group 2-7, experimental group 2-8, experimental group 2-9, experimental group 2-10, control group 6, control group 7, and control group 8. Among them, the material composition of the liquid preparation provided by experimental group 2-1 is shown in Table 5.

[0081] The difference between experimental groups 2-2 to 2-10 and control groups 6 to 8 and experimental group 2-1 is that the feeding amounts of the sparingly soluble calcium salt, soluble calcium salt and magnesium salt are respectively regulated according to Table 6. The other raw material proportions and preparation methods are strictly consistent with those of experimental group 2-1.

[0082] Table 5. Raw material composition for preparing liquid preparations in experimental group 2-1

[0083]

[0084] The specific preparation method of the liquid preparation includes the following operations:

[0085] S1. Mixing vitamin D and vegetable oil, and then heating to 80° C. for 10 min, thereby obtaining a first reaction solution;

[0086] S2. The emulsifier and purified water were configured as a second reaction solution, and then the first reaction solution and the second reaction solution were mixed and dispersed at a speed of 9000 rpm for 5 minutes to form an emulsion;

[0087] S3. Mix the calcium salt and magnesium salt with the emulsion, mix at a speed of 5000 prm for 5 minutes to disperse, obtain a liquid preparation, and then sterilize the liquid preparation by pasteurization to obtain a finished product. The pasteurization temperature is 90° C. and the sterilization time is 30 minutes.

[0088] Table 6. Composition of raw materials used to prepare liquid preparations in Experiment IV

[0089]

[0090] 2. Test the above liquid preparations

[0091] Participants: Liquid preparations provided by experimental groups 2-1 to 2-10 and control groups 6 to 8

[0092] Test items and test methods:

[0093] (1) Viscosity: Refer to the test method of "Chinese Pharmacopoeia 2020 Edition Part IV General Viscosity Determination Method" and use a rotor type rotational viscometer to test the test objects. When the viscosity is ≤2000cP, it is considered to meet the requirements.

[0094] (2) Vitamin D retention rate:

[0095] According to the test method of GB 5009.82-2016 National Food Safety Standard Determination of Vitamin A, D and E in Food, the test objects were placed in a 60°C environment for 10 days. The vitamin D content in the test objects was then tested using an Agilent 1260 high performance liquid chromatograph.

[0096] Among them, the vitamin D retention rate = vitamin content after 10 days of high temperature testing at 60°C / vitamin theoretical content * 100%. Among them, when the retention rate ≥ 80%, it is considered to meet the requirements.

[0097] The test results are shown in Table 7.

[0098] Table 7. Test results of the above subjects

[0099]

[0100] Result analysis:

[0101] From the test results of the liquid preparations provided by experimental groups 2-1 to 2-10 and control groups 6 to 8 in the above table, the viscosity of the liquid preparations provided by experimental groups 2-1 to 2-10 was ≤2000cP, while the liquid preparations of control groups 6 to 8 were in a solidified state. This shows that when the mass ratio of the insoluble calcium salt, the soluble calcium salt and the magnesium salt in the liquid preparation is 3 to 15:1 to 5.5:1 to 11, and the mass ratio of the insoluble calcium salt to the soluble calcium salt is 1.6 to 7:1, the viscosity of the liquid preparation is small and the fluidity of the liquid preparation is good. At the same time, combined with the viscosity of the composition containing minerals provided by Experiment Ⅰ and the liquid preparation provided by Experiment Ⅳ, whether it is a composition system containing minerals or a liquid preparation system, when the mass ratio of the insoluble calcium salt, soluble calcium salt and magnesium salt in the system is 3-15:1-5.5:1-11, and the mass ratio of the insoluble calcium salt to the soluble calcium salt is 1.6-7:1, the viscosity of the system can reach the requirement of ≤2000cP. In actual experiments, it was found that when the mass ratio of the insoluble calcium salt, soluble calcium salt and magnesium salt in the composition containing minerals is consistent with the mass ratio of the insoluble calcium salt, soluble calcium salt and magnesium salt in the liquid preparation, the viscosity of the composition is very close to the viscosity of the liquid preparation, that is, the mass ratio of the insoluble calcium salt, soluble calcium salt and magnesium salt is the main determinant of the viscosity of the system.

[0102] By comparing the vitamin D retention rates of the liquid preparations provided by experimental groups 2-1 to 2-10, it can be found that the vitamin D retention rates of the liquid preparations provided by experimental groups 2-1 to 2-3 and experimental groups 2-5 to 2-10 after storage at 60°C for 10 days were all ≥80%, while the vitamin D retention rate of the liquid preparation provided by experimental group 2-4 was only 78.4%. This shows that when the mass ratio of insoluble calcium salts, soluble calcium salts and magnesium salts in the liquid preparation is 3-15:1-5.5:1-11, and the mass ratio of insoluble calcium salts to soluble calcium salts is 1.9-7:1, not only can the fluidity and viscosity of the liquid preparation be ensured to be good, but the storage stability of vitamin D in the liquid preparation can also be improved.

[0103] In addition, referring to the preparation method of experimental group 2-1, and according to the variables shown in Table 3 and Table 4 of experimental group 1-11 to experimental group 1-29, liquid preparations were prepared, and the remaining raw material composition and preparation method were strictly consistent with experimental group 2-1. After testing, it was found that the liquid preparations corresponding to experimental group 1-11 to experimental group 1-29 had a vitamin retention rate of ≥80%. This shows that when the insoluble calcium salt adopts at least one of calcium citrate, calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, and calcium citrate malate; or when the magnesium salt adopts at least one of magnesium gluconate, L-magnesium threonate, magnesium citrate, magnesium chloride, and magnesium glycinate; or when the soluble calcium salt adopts at least one of calcium gluconate, L-calcium lactate, calcium lactate, calcium chloride, and calcium acetate; or further includes metal salts and / or selenium salts (for example, the metal salt includes magnesium, iron, zinc, copper, and manganese), the storage stability of vitamin D is less affected.

[0104] Experiment V

[0105] 1. Preparation of liquid preparations

[0106] This example refers to the preparation method provided by Experimental Group 2-2 to prepare a liquid preparation. The difference between this experimental group and Experimental Group 2-2 is that the raw material composition of the liquid preparation is regulated according to Table 8. The remaining raw material ratios and preparation methods are strictly consistent with those of Experimental Group 2-2, especially the raw material composition not shown in Table 8 is strictly consistent with that of Experimental Group 2-2.

[0107] Table 8. Composition of raw materials used to prepare liquid formulations in Experiment V

[0108]

[0109]

[0110] 2. Use the test method in Experiment IV to test the above liquid preparations

[0111] Test results: The viscosity of the liquid preparations provided by experimental groups 2-11 to 2-17 was ≤2000cP, and the measured vitamin retention rate was ≥80%. This shows that when the emulsifier is at least one of gum arabic, sodium starch octenyl succinate, polyglycerol fatty acid ester, and sucrose fatty acid ester, the prepared liquid preparation has both suitable viscosity and excellent vitamin storage stability. When the mass ratio of the insoluble calcium salt to the soluble calcium salt is in the range of 1.6 to 7:1, or when the mass proportion of the vitamin in the liquid preparation is in the range of 0.00001wt% to 0.0001wt%, or when the mass proportion of the emulsifier in the liquid preparation is in the range of 1wt% to 10wt%, the prepared liquid preparation has both suitable viscosity and excellent vitamin storage stability. Among them, in the process of actual application and testing, it was found that when the mass ratio of insoluble calcium salt to soluble calcium salt is in the range of 1.6 to 7:1, the storage stability of the liquid preparation is better, and the calcium and magnesium content in the liquid preparation is higher, which is conducive to simplifying the taking process and improving the nutritional supplement effect.

[0112] Experiment VI

[0113] 1. Preparation of liquid preparations

[0114] This example refers to the preparation method provided by Experimental Group 2-2 to prepare a liquid preparation. The difference between this experimental group and Experimental Group 2-2 is that a thickener, a filler, an acidity regulator, a flavor, a pigment, and a nutrient component are introduced into the liquid preparation according to the raw material composition provided in Table 9. The remaining raw material ratios and preparation methods are strictly consistent with those of Experimental Group 2-2.

[0115] Table 9. Composition of raw materials used to prepare liquid formulations in Experiment VI

[0116]

[0117]

[0118] 2. Use the test method in Experiment IV to test the above liquid preparations

[0119] Test results: The viscosity of the liquid preparations provided by experimental groups 2-18 to 2-32 is ≤2000cP, and the measured vitamin retention rate is ≥80%. This shows that when the liquid preparation includes at least one of a thickener, a filler, an acidity regulator, a flavor, a pigment, and a nutrient, it is not only beneficial to supplement the nutrients required by the human body, but also the liquid preparation has a suitable viscosity and excellent vitamin storage stability. Moreover, in actual tests, it was found that when the introduced nutrient ingredients are at least one of vitamins, amino acids, proteins, polyphenols, glycosides, lipids, polysaccharides, ω-based polyunsaturated fatty acids, L-carnitine, enzymes, and coenzyme Q10, the viscosity of the prepared liquid preparation is ≤2000cP, and the measured vitamin retention rate is ≥80%. That is to say, compared with insoluble calcium salts, soluble calcium salts and magnesium salts, the above-mentioned adjuvants and / or nutrients have less effect on the viscosity of the liquid preparation and the storage stability of vitamin D.

[0120] The above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the protection scope of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A composition containing minerals, characterized in that It includes calcium salt, magnesium salt and aqueous solvent, wherein the calcium salt includes insoluble calcium salt and soluble calcium salt, the solubility of the insoluble calcium salt is less than 1g / 100mL, and the solubility of the soluble calcium salt is greater than 3g / 100mL; the mass ratio of the insoluble calcium salt, the soluble calcium salt and the magnesium salt is 3-15:1-5.5:1-11; the mass ratio of the insoluble calcium salt to the soluble calcium salt is 1.6-7:1; preferably, the aqueous solvent is water.

2. The composition containing minerals according to claim 1, characterized in that The poorly soluble calcium salt includes at least one of calcium citrate, calcium hydrogen phosphate, calcium dihydrogen phosphate, tricalcium phosphate, and calcium citrate malate.

3. The composition containing minerals according to claim 1, characterized in that: The magnesium salt includes at least one of magnesium gluconate, magnesium L-threonate, magnesium citrate, magnesium chloride, and magnesium glycinate.

4. The composition containing minerals according to claim 1, characterized in that: The soluble calcium salt includes at least one of calcium gluconate, calcium L-lactate, calcium lactate, calcium chloride and calcium acetate.

5. The composition containing minerals according to claim 1, characterized in that: It also includes metal salts and / or selenium salts, and the metal salt includes at least one of iron salts, zinc salts, copper salts, and manganese salts.

6. The composition containing minerals according to claim 5, characterized in that The total weight percentage of the metal salt and the selenium salt in the composition is no more than 2.5 wt %.

7. A liquid preparation, characterized in that The invention comprises an oily solvent, vitamin D, an emulsifier and the mineral-containing composition according to any one of claims 1 to 6.

8. The liquid preparation according to claim 7, characterized in that It also includes at least one of a thickener, a filler, an acidity regulator, a flavor, a pigment, and a nutrient.

9. The liquid preparation according to claim 7, characterized in that The method for preparing the liquid preparation comprises the following operations: S1. mixing the vitamin D with the oily solvent, and then heating to 75-85° C., thereby obtaining a first reaction liquid; S2. configuring the emulsifier and the aqueous solvent into a second reaction liquid, and then mixing the first reaction liquid with the second reaction liquid to form an emulsion after dispersion treatment; S3. Mixing the calcium salt, the magnesium salt and the emulsion, and obtaining the liquid preparation after dispersion treatment.

10. Use of the mineral-containing composition according to any one of claims 1 to 6 or the liquid preparation according to any one of claims 7 to 9 in food, medicine or cosmetics; preferably, the food is a health food.

Images