Preparation method of efficient magnetocaloric effect functional bone cement based on liquid metal

Abstract

The invention discloses a preparation method of liquid metal-based efficient magnetocaloric effect functional bone cement, which is characterized by comprising the following steps: step 1, preparing raw materials including liquid bone cement and liquid metal; 2, the liquid metal and the liquid bone cement refrigerated in advance serve as an inner phase and an outer phase of a coaxial needle tube respectively, the flow, time and temperature of the inner phase and the outer phase are set, the inner phase and the outer phase intersect to form functional bone cement through the coaxial shearing technology, then the liquid bone cement is solidified, and the final state is obtained. Liquid metal droplets are implanted into bone cement as required through a coaxial interface shearing technology, efficient and on-demand heating and accurate and controllable heating temperature can be realized under the action of a low-intensity alternating magnetic field, and the device has the characteristics of high pertinence, controllable heating temperature, rapid temperature rise and the like; the method has an excellent application prospect in cancer treatment after bone metastasis of medical cancer cells.

Description

Technical Field

[0001] The invention relates to the technical field of thermal therapy, and in particular to a method for preparing liquid metal-based high-efficiency magnetothermal effect functional bone cement. Background Art

[0002] Cancer metastasis can seriously affect the patient's life, among which bone tissue is a common area of ​​cancer metastasis. In most cases, necessary orthopedic surgery must be performed while treating such cancerous diseases. The purpose is to surgically remove the cancerous soft tissue and adjacent bone tissue to prevent further spread of cancer cells. After the cancerous bone tissue is removed, bone cement is usually used to fill the bone defect to increase the mechanical strength of the bone and reduce the risk of fractures, paralysis, and even amputation. At the same time, bone cement can also release heat during the curing process to further kill cancer cells. Now there is an urgent need for a new technology method that is highly targeted, responsive, small incision, and can solve the problem of cancer recurrence.

[0003] Depending on the treatment method, the common treatment methods for cancer bone metastasis are as follows:

[0004] 1. Surgery: It mainly involves enlarging the tumor site and filling the defect with bone cement to increase the mechanical strength of the bone and reduce the risk of fracture. At the same time, bone cement releases heat during the curing process, which can perform a single thermal killing of tumor cells that have not been completely removed.

[0005] Advantages: Precise surgical resection; bone cement filling can reduce the risk of fracture and further thermally kill the tumor;

[0006] Disadvantages: Bone cement releases heat once; the heating process is uncontrollable; there is a risk of recurrence; the cost is high;

[0007] 2. Chemotherapy: Use chemotherapeutic drugs to kill cancer cells to achieve the purpose of treatment.

[0008] Advantages: Improve the therapeutic effect of malignant tumors; effectively inhibit the metastasis of cancer cells;

[0009] Disadvantages: limited application; unable to distinguish normal cells from cancer cells; serious side effects; decreased immunity;

[0010] 3. Radiation therapy: a method of treating malignant tumors using radiation.

[0011] Advantages: precise; low risk of infection; small incision;

[0012] Disadvantages: Produce local bone marrow suppression; affect the patient's immunity;

[0013] 4. Magnetic thermal therapy: The hysteresis loss and Brownian relaxation of magnetic materials in an alternating magnetic field cause the dissipation of internal energy of the material, resulting in a local heating effect and killing cancer cells, thus achieving targeted cancer treatment.

[0014] Advantages: Precision treatment; High biosafety; Deep tissue penetration;

[0015] Disadvantages: low heating efficiency; lack of external control effect; cannot regulate the thermal killing temperature well;

[0016] The above treatment methods are relatively common in clinical practice, but they also have obvious disadvantages. For example, most of them cannot cope with the risk of cancer recurrence, resulting in the inability to suppress bone metastasis in time; at the same time, most of them will affect the patient's immunity, resulting in a decrease in the patient's own anti-cancer ability.

[0017] The present invention proposes a preparation method design of a high-efficiency magnetocaloric effect functional bone cement based on liquid metal. The functional bone cement is prepared by uniformly mixing bone cement and magnetocaloric agent. After applying an external magnetic field, the functional bone cement burns cancer cells by heating the liquid metal. The functional bone cement has the specific features of precise regulation of cancer cells, good biocompatibility, high sensitivity, rapid response, repeated effects, and small wounds. Summary of the invention

[0018] The present invention aims at solving the problems of mechanical stability and tumor treatment effect of bone cement and provides a method for preparing a novel functional bone cement.

[0019] The present invention provides the following technical solutions:

[0020] A method for preparing a high-efficiency magnetocaloric effect functional bone cement based on liquid metal, characterized by: step one: preparing raw materials, the raw materials including liquid bone cement and liquid metal; step two: using the liquid metal and the pre-refrigerated liquid bone cement as the inner phase and outer phase of a coaxial needle tube respectively, setting the flow rate, time and temperature of the inner phase and the outer phase, using coaxial shear technology to make the inner phase and the outer phase intersect to form functional bone cement, and then solidifying the liquid bone cement to obtain the final state.

[0021] Preferably, the flow rate of the inner phase is 0.5 ml / min, the flow rate of the outer phase is 0.15 ml / min, the time is 1 s, and the temperature is 19°C.

[0022] Preferably, the liquid bone cement includes polymethyl methacrylate bone cement, calcium phosphate bone cement, or calcium sulfate bone cement.

[0023] Preferably, the liquid metal is a gallium-based liquid metal, and the liquid metal includes gallium, gallium-indium alloy, or gallium-indium-tin alloy.

[0024] Preferably, the method for preparing the polymethyl methacrylate bone cement is: stirring 26 g of polymethyl methacrylate powder and 10 ml of liquid monomer for 20 seconds to obtain the polymethyl methacrylate bone cement, and the ratio of the mass of the polymethyl methacrylate powder to the volume of the liquid monomer is about 2.6W / V.

[0025] Preferably, the polymethyl methacrylate powder consists of 14.2 g of methyl methacrylate, 11.7 g of zirconium dioxide and 0.1 g of benzoyl peroxide.

[0026] Preferably, the liquid monomer includes 9.2 g of methyl methacrylate and 0.2 g of N,N-dimethyl-p-toluidine.

[0027] The beneficial effects of the present invention are: liquid metal droplets are implanted into bone cement as needed through coaxial interface shear technology, and under the action of a low-intensity alternating magnetic field, efficient and on-demand heating can be achieved, and the heating temperature can be precisely controlled. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 is a schematic structural diagram of the functional bone cement of the present invention;

[0029] Figure 2 is a flow chart of a method for preparing a functional bone cement according to one embodiment;

[0030] Figure 3 It is a schematic diagram of the structure of the coaxial needle tube;

[0031] Figure 4 This is a schematic diagram of the rapid temperature increase of functional bone cement; DETAILED DESCRIPTION

[0032] The technical solution of this patent is further described in detail below in conjunction with specific implementation methods.

[0033] In the description of the present invention, it should be noted that the terms "inside", "outside", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0034] like Figures 1 to 4As shown, the present invention provides a method for preparing a high-efficiency magnetocaloric effect functional bone cement based on liquid metal, characterized in that: Step 1: Prepare raw materials, the raw materials include liquid bone cement and liquid metal, put the liquid bone cement into a refrigerator in advance to prevent the liquid bone cement from solidifying too quickly under high temperature. Step 2: Prepare a coaxial needle tube 1, the coaxial needle tube 1 includes an inner tube 11 for conveying an inner phase fluid, an outer tube 2 for conveying an outer phase fluid, and a tip portion (not shown) for mixing the inner phase and the outer phase, respectively, and use the liquid metal and the pre-refrigerated liquid bone cement as the inner phase and the outer phase of the coaxial needle tube 1, and set the flow rate, time and temperature of the inner phase and the outer phase. Specifically, the flow rate of the inner phase is 0.5ml / min, the flow rate of the outer phase is 0.15ml / min, the time is 1s, and the temperature is 19°C. Using coaxial shear technology, the inner phase and the outer phase intersect to form a functional bone cement, and then the liquid bone cement solidifies to obtain the final state.

[0035] Furthermore, the liquid bone cement 3 includes but is not limited to polymethyl methacrylate PMMA bone cement, calcium phosphate bone cement, calcium sulfate bone cement, etc. The liquid metal 2 is a gallium-based liquid metal, and the liquid metal includes gallium, gallium-indium alloy, gallium-indium-tin alloy, etc. The present invention can control the heating efficiency of the bone cement by adjusting the droplet size, shape, distribution mode, etc. of the liquid metal 2.

[0036] The present invention takes polymethyl methacrylate (PMMA) bone cement as an example. The method for preparing the polymethyl methacrylate (PMMA) bone cement is as follows: 26 g of polymethyl methacrylate (PMMA) powder and 10 ml of liquid monomer are stirred for 20 seconds to obtain the polymethyl methacrylate (PMMA) bone cement, wherein the ratio of the mass of the polymethyl methacrylate (PMMA) powder to the volume of the liquid monomer is approximately 2.6 W / V.

[0037] Specifically, the polymethyl methacrylate (PMMA) powder is composed of 14.2 g of methyl methacrylate (MMA), 11.7 g of zirconium dioxide and 0.1 g of benzoyl peroxide. The liquid monomer includes 9.2 g of methyl methacrylate (MMA) and 0.2 g of N,N-dimethyl-p-toluidine.

[0038] The present invention uses coaxial interface shearing technology to implant liquid metal 2 droplets into bone cement 3 on demand, and under the action of a low-intensity alternating magnetic field, it can achieve efficient, on-demand heating, and the heating temperature is precisely controllable. Functional bone cement has the characteristics of strong targeting, controllable heating temperature, and rapid heating. Figure 4 As shown, it has excellent application prospects in cancer treatment after bone metastasis of medical cancer cells.

[0039] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0040] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A method for preparing a liquid metal-based high-efficiency magnetocaloric effect functional bone cement, characterized in that: Step 1: Prepare raw materials, including liquid bone cement and liquid metal; Step 2: Use liquid metal and pre-refrigerated liquid bone cement as the inner phase and outer phase of the coaxial needle tube respectively, set the flow rate, time and temperature of the inner phase and outer phase, and use coaxial shear technology to make the inner phase and outer phase intersect to form functional bone cement, and then the liquid bone cement solidifies to obtain the final state.

2. The method for preparing a liquid metal-based high-efficiency magnetocaloric effect functional bone cement according to claim 1, characterized in that: The flow rate of the inner phase is 0.5 ml / min, the flow rate of the outer phase is 0.15 ml / min, the time is 1 s, and the temperature is 19°C.

3. The method for preparing the liquid metal-based high-efficiency magnetocaloric effect functional bone cement according to claim 2, characterized in that: The liquid bone cement includes polymethyl methacrylate bone cement, calcium phosphate bone cement, and calcium sulfate bone cement.

4. The method for preparing the liquid metal-based high-efficiency magnetocaloric effect functional bone cement according to claim 2, characterized in that: The liquid metal is a gallium-based liquid metal, and the liquid metal includes gallium, gallium-indium alloy, and gallium-indium-tin alloy.

5. The method for preparing the liquid metal-based high-efficiency magnetocaloric effect functional bone cement according to claim 1, characterized in that: The method for preparing the polymethyl methacrylate bone cement is: 26g of polymethyl methacrylate powder and 10ml of liquid monomer are stirred for 20s to obtain the polymethyl methacrylate bone cement, and the ratio of the mass of the polymethyl methacrylate powder to the volume of the liquid monomer is about 2.6W / V.

6. The method for preparing a high-efficiency magnetocaloric effect functional bone cement based on liquid metal according to claim 4, characterized in that: The polymethyl methacrylate powder consists of 14.2 g of methyl methacrylate, 11.7 g of zirconium dioxide and 0.1 g of benzoyl peroxide.

7. The method for preparing a high-efficiency magnetocaloric effect functional bone cement based on liquid metal according to claim 4, characterized in that: The liquid monomers include 9.2 g of methyl methacrylate and 0.2 g of N,N-dimethyl-p-toluidine.

Images