A tablet dissolution release testing device

Abstract

The invention relates to a tablet dissolution and release detection device applied to the technical field of experimental detection equipment, comprising a device tank body, a dissolution tube, a peristaltic bag, a lifting and perturbation module, a drug cage, a tablet to be tested, an overflow hole, a liquid inlet tube, a liquid inlet plug, a temporary storage tube section and a communicating tube. The invention uses the lifting and perturbation module to repeatedly push the peristaltic bag to deform, so that the solution is repeatedly squeezed into the dissolution tube, so that the solution repeatedly flushes the tablet to be tested in the drug cage, effectively improving the dissolution efficiency of the tablet to be tested, and the solution overflows outwards through the overflow hole to simulate the absorption of the drug by the intestine, effectively improving the accuracy of tablet dissolution and release detection data, and another part of the solution enters the temporary storage tube section through the communicating tube for storage, and the solution subsequently returns to the peristaltic bag through the liquid inlet tube, and new solution is supplemented to make up for the overflowed solution, effectively improving the circulation of the solution between the liquid inlet tube and the peristaltic bag, and further effectively improving the dissolution and release effect of the tablet to be tested in the solution.

Description

Technical Field

[0001] The invention relates to a tablet testing device, in particular to a tablet dissolution release testing device applied in the technical field of experimental testing equipment. Background Art

[0002] Drug dissolution and release testing is an important means to evaluate the release and absorption characteristics of drug preparations in the body. These tests help ensure the quality, safety and efficacy of drugs. The results of drug dissolution and release tests can be used to optimize the formulation and production process of drug preparations and ensure the quality and efficacy of drugs. At the same time, these test results can also be used to support the registration and approval of drugs.

[0003] The specification of Chinese invention patent CN202110640406.6 discloses a "Two-chamber model experimental device for simulating the in vivo release and absorption process of drugs". By simulating the use of a gastric pouch and a hammer stirring device, regular stirring of the dissolution medium in the inner dissolution chamber and the dissolution liquid in the outer dissolution chamber is achieved, effectively avoiding the problem of uneven stirring of the inner dissolution chamber and the outer dissolution chamber. The double-layer flushing and dissolution of the input dissolution medium and the up and down moving dissolution medium can simulate the movement of gastrointestinal fluid, comprehensively regulate the dissolution behavior of the drug, and match the in vitro dissolution rate and dissolution efficiency of the drug with the in vivo process. On the one hand, it is conducive to achieving in vitro and in vivo correlation. On the other hand, since the dissolution medium continuously moves up and down as a whole, dissolution can be achieved without dead angles, and the drug absorption part will not be blocked, there will be no convex or concave points in the dissolution curve, and there will be no drug accumulation.

[0004] The existing tablet release detection method mainly involves placing the tablets in a placement basket, and then placing the tablets in a dissolving container to dissolve the tablets using an artificial solution. The above invention also adopts a similar method, but the amount of artificial solution in the dissolving container is fixed, and the medicine basket containing the tablets is only immersed in the solution. The dissolution and release state of the tablets in the solution is relatively static, and it is impossible to simulate the disturbance of the human digestive system to the drugs. The above invention only disturbs the solution outside the medicine basket, but does not allow the solution to directly act on the inside of the medicine basket, affecting the dissolution and release efficiency of the tablets in the solution. The concentration of the drug components in the solution gradually increases with the dissolution time, and the saturation of the solution affects the subsequent dissolution and release of the tablets. On the other hand, when the tablets are dissolved and released in the intestine, the drug components released by the tablets will be absorbed by the intestine, and the concentration of the drug components in the intestine is in a relatively balanced state. The existing tablet release detection method cannot meet this state, thus affecting the accuracy of the detection result. Summary of the invention

[0005] In view of the above-mentioned prior art, the technical problem to be solved by the present invention is that the disturbance effect of the solution is not strong, which affects the dissolution and release efficiency of the tablets in the solution, and the concentration of the drug components in the solution gradually increases with the dissolution time, and the highly saturated solution affects the subsequent dissolution and release of the tablets.

[0006] In order to solve the above problems, the present invention provides a tablet dissolution release rate detection device, comprising a device tank body, a dissolution tube is fixedly connected to the top of the device tank body, a peristaltic bag is fixedly connected to the bottom of the dissolution tube, a lifting disturbance module is fixedly connected to the bottom of the device tank body, the top of the lifting disturbance module is fixedly connected to the middle of the bottom end of the peristaltic bag, a drug cage is placed inside the dissolution tube, and a tablet to be tested is placed inside the drug cage;

[0007] An overflow bucket is fixedly connected to the outside of the top of the dissolving tube, an overflow hole is opened between the overflow bucket and the top of the dissolving tube, a liquid inlet pipe is fixedly connected to one end of the top of the equipment tank body, the bottom end of the liquid inlet pipe is connected to the top of the peristaltic bag, and the top height of the liquid inlet pipe is greater than the height of the overflow bucket, a liquid inlet plug is inserted at the bottom of the liquid inlet pipe, a limiting rib is fixedly connected between the top of the liquid inlet plug and the lower opening of the liquid inlet pipe, an elastic bridge is fixedly connected between the bottom of the liquid inlet plug and the middle of the bottom end of the peristaltic bag, a temporary storage pipe section is fixedly connected to the top of the liquid inlet pipe, a communicating pipe is fixedly connected between the top of the temporary storage pipe section and the top of the dissolving tube, and the communicating pipe corresponds horizontally to the overflow hole.

[0008] In the above-mentioned tablet dissolution and release test equipment, the peristaltic bag is deformed by repeatedly pushing the lifting disturbance module, and the solution overflows outward through the overflow hole when rising to simulate the intestinal absorption of the drug. More solution is collected into the temporary storage tube section through the connecting tube, and then returns to the temporary storage tube section through the liquid inlet tube. At the same time, new solution is added to make up for the overflow solution, effectively avoiding excessive saturation of the solution, thereby effectively improving the accuracy of the test results.

[0009] As a further improvement of the present application, the bottom of the peristaltic bag is set in a conical shape, and a counterweight ring is placed on the outside of the cone at the bottom of the peristaltic bag. The peristaltic bag is made of wear-resistant rubber material, and the counterweight ring is made of stainless steel material. The conical bottom of the peristaltic bag can be better concavely deformed, and the counterweight ring is used to achieve the falling of the bottom of the peristaltic bag, effectively improving the recovery effect of the peristaltic bag.

[0010] As a further improvement of the present application, the drug cage is located at the connection part between the dissolving tube and the peristaltic bag, and the top of the drug cage is fixedly connected to a support rod, the top of the support rod is fixedly connected to a tube plug, and the tube plug is plugged into the top of the dissolving tube. By plugging the tube plug into the dissolving tube, it is convenient to fix the drug cage through the support rod, thereby facilitating the drug cage to be stably located at the connection part between the dissolving tube and the peristaltic bag, effectively improving the dissolution effect of the tablets inside the drug cage.

[0011] As a further improvement of the present application, the limiting ribs are bent in a U-shape, and the limiting ribs are made of elastic rubber material, and the elastic bridge is made of spring steel, which effectively improves the elastic performance of the limiting ribs and the elastic bridge.

[0012] As another improvement of the present application, the diameter of the temporary storage pipe segment is larger than the diameter of the liquid inlet pipe, and the diameter of the communicating pipe is larger than the diameter of the overflow hole. The larger diameter communicating pipe makes the solution entering the temporary storage pipe segment through the communicating pipe larger than the solution overflowing from the overflow hole, so that more solution can circulate between the peristaltic bag and the liquid inlet pipe. The larger diameter temporary storage pipe segment can store more solution.

[0013] As another improved supplement of the present application, a scraping module is movably connected inside the drug cage, and the scraping module is in contact with the tablet to be tested. The scraping module is used to scrape the tablet to be tested. The scraping module simulates the food coexisting with the tablet, effectively improving the validity of the experimental test results.

[0014] As another improvement supplement of the present application, the top of the scraping module is fixedly connected to a connecting rod, the top of the connecting rod extends to the overflow hole, and the top of the connecting rod is fixedly connected to a floating module. The floating module and the connecting rod are utilized to achieve synchronous movement of the scraping module following the rising and falling movement of the solution, thereby effectively improving the scraping effect of the scraping module and the tablet to be tested.

[0015] As another improvement of the present application, the scraping modules are arranged in multiple layers, and each layer of the scraping modules is composed of a combination of cotton wool, glass fiber yarn and glass beads. The multiple layers of scraping modules are composed of different materials, which effectively improves the complexity of the scraping effect on the tablets to be tested.

[0016] As a supplement to another improvement of the present application, a medicine cage opening is provided at the bottom end of the medicine cage, a closing plug is inserted into the inside of the medicine cage opening, an umbrella support cover is fixedly connected to the top of the closing plug, the tablet to be tested is at the top of the umbrella support cover, the layer gap of the scraping module is correspondingly engaged with the outer ring edge of the umbrella support cover, the umbrella support cover is made of elastic rubber material, the tablet to be tested is placed in the medicine cage through the medicine cage opening, and the medicine cage opening is quickly closed through the closing plug, and at the same time, the lowest height of the tablet to be tested in the medicine cage is limited by the umbrella support cover, so as to effectively prevent the tablet to be tested from sinking to the bottom of the medicine cage.

[0017] In summary, the present invention repeatedly pushes the peristaltic bag to deform through the lifting disturbance module, so that the solution is repeatedly squeezed into the dissolution tube, and the solution is lifted and lowered in the dissolution tube, so that the solution repeatedly flushes the tablets to be tested in the drug cage to simulate the influence of intestinal peristalsis on the drug, effectively improving the dissolution efficiency of the tablets to be tested, and when the solution rises, it overflows outward through the overflow hole to simulate the absorption of the drug by the intestine, effectively improving the accuracy of the tablet dissolution and release test data, and another part of the solution enters the temporary storage tube section through the communicating tube for storage. When the shape of the peristaltic bag is restored later, the solution inside the temporary storage tube section returns to the peristaltic bag through the liquid inlet tube, and new solution is added to make up for the overflowed solution, effectively improving the circulation of the solution between the liquid inlet tube and the peristaltic bag, further effectively improving the dissolution and release effect of the tablets to be tested in the solution, and effectively avoiding the oversaturation of the drug components in the solution, thereby effectively avoiding the influence of the oversaturation of the solution on the dissolution efficiency of the tablets to be tested, and further effectively improving the accuracy of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a three-dimensional structural diagram of the first embodiment of the present application;

[0019] Figure 2 This is a sectional three-dimensional structural diagram of the first embodiment of the present application;

[0020] Figure 3 This is a demonstration diagram of the downward movement of the solution in the dissolving tube according to the first embodiment of the present application;

[0021] Figure 4 This is a demonstration diagram of the upward movement of the solution in the dissolving tube according to the first embodiment of the present application;

[0022] Figure 5 This is a cross-sectional view of a peristaltic bag according to a first embodiment of the present application;

[0023] Figure 6 This is a three-dimensional structural diagram of the liquid inlet plug and the elastic bridge of the first embodiment of the present application;

[0024] Figure 7 This is a three-dimensional structural diagram of a drug cage and a scraping module according to a second embodiment of the present application;

[0025] Figure 8 This is a three-dimensional structural diagram of a scraping module and a tablet to be tested according to a second embodiment of the present application;

[0026] Fig. 9 This is a three-dimensional structural diagram of the drug cage, the scraping module and the sealing plug according to the second embodiment of the present application.

[0027] Description of the numbers in the figure:

[0028] 1. Equipment tank; 101. Dissolution tube; 102. Peristaltic bag; 103. Lifting disturbance module; 104. Pipe plug; 105. Support rod; 106. Drug cage; 107. Counterweight ring; 2. Tablets to be tested; 3. Overflow hopper; 301. Overflow hole; 302. Liquid inlet pipe; 303. Liquid inlet plug; 304. Limiting rib; 305. Elastic bridge; 306. Temporary storage tube section; 307. Interconnecting tube; 4. Scraping module; 401. Connecting rod; 402. Floating module; 403. Drug cage mouth; 404. Closing plug; 405. Umbrella cover. DETAILED DESCRIPTION

[0029] Two implementation modes of the present application are described in detail below with reference to the accompanying drawings.

[0030] The first implementation method:

[0031] Figures 1 to 4 FIG. 1 shows a device for detecting dissolution and release of tablets, comprising a device tank 1, a dissolution tube 101 is fixedly connected to the top of the device tank 1, a peristaltic bag 102 is fixedly connected to the bottom of the dissolution tube 101, a lifting disturbance module 103 is fixedly connected to the bottom of the device tank 1, the top of the lifting disturbance module 103 is fixedly connected to the middle of the bottom end of the peristaltic bag 102, a drug cage 106 is placed inside the dissolution tube 101, a tablet 2 to be tested is placed inside the drug cage 106, the drug cage 106 is at the connection between the dissolution tube 101 and the peristaltic bag 102, and the drug cage 106 is 6 is fixedly connected with a support rod 105, and the top of the support rod 105 is fixedly connected with a pipe plug 104, and the pipe plug 104 is plugged with the top of the dissolving tube 101. The bottom of the peristaltic bag 102 is set in a cone shape, and a counterweight ring 107 is placed outside the cone of the bottom of the peristaltic bag 102. The peristaltic bag 102 is made of wear-resistant rubber material, and the counterweight ring 107 is made of stainless steel material. The bottom of the conical peristaltic bag 102 can be better concavely deformed, and the counterweight ring 107 is used to realize the falling of the bottom of the peristaltic bag 102, which effectively improves the recovery effect of the peristaltic bag 102;

[0032] When performing the dissolution release test of the tablet 2 to be tested, the tablet 2 to be tested is placed in the drug cage 106, and then the drug cage 106 is inserted into the dissolution tube 101. The peristaltic bag 102 is repeatedly pushed and deformed by the lifting disturbance module 103, so that the solution in the peristaltic bag 102 is squeezed into the dissolution tube 101, and the solution is repeatedly flushed to the tablet 2 to be tested in the drug cage 106, so as to simulate the effect of intestinal peristalsis on drug dissolution, effectively improve the dissolution efficiency of the tablet 2 to be tested, and effectively improve the accuracy of the tablet dissolution release test data.

[0033] Figures 2 to 4As shown, the top of the dissolving tube 101 is fixedly connected to an overflow hopper 3, an overflow hole 301 is provided between the overflow hopper 3 and the top of the dissolving tube 101, and a liquid inlet pipe 302 is fixedly connected to one end of the top of the equipment tank body 1, the bottom end of the liquid inlet pipe 302 is connected to the top of the peristaltic bag 102, and the top height of the liquid inlet pipe 302 is greater than the height of the overflow hopper 3;

[0034] When the solution moves upward in the dissolving tube 101, the solution overflows from the overflow hole 301, and the overflowed solution is collected and recovered by the overflow hopper 3. The drug components in the overflowed solution simulate the absorption of the drug by the intestine, effectively improving the accuracy of the tablet dissolution and release test data. When the new solution is added to the peristaltic bag 102 by using the liquid inlet tube 302, the overall concentration of the solution is diluted, which effectively avoids the oversaturation of the drug components in the solution. In the state of oversaturation of the solution, the drug is difficult to dissolve and release into the solution, thereby effectively avoiding the oversaturation of the solution affecting the dissolution efficiency of the tablet 2 to be tested, thereby further effectively improving the accuracy of the test results.

[0035] Figures 3 to 6 As shown, a liquid inlet plug 303 is inserted into the bottom of the liquid inlet tube 302, and a limiting rib 304 is fixedly connected between the top of the liquid inlet plug 303 and the lower opening of the liquid inlet tube 302. The limiting rib 304 is bent in a U shape and is made of elastic rubber material. An elastic bridge 305 is fixedly connected between the bottom of the liquid inlet plug 303 and the middle of the bottom end of the peristaltic bag 102. The elastic bridge 305 is made of spring steel. The elastic force of the limiting rib 304 is used to push the liquid inlet plug 303 down, and the bottom of the liquid inlet tube 302 is automatically opened. During the deformation process of the peristaltic bag 102, the elastic bridge 305 is used to realize the closure of the bottom of the liquid inlet tube 302 by the liquid inlet plug 303, effectively preventing the solution from reversely entering the liquid inlet tube 302 during the rising process. At the same time, the elastic bridge 305 with elastic force facilitates the subsequent deformation of the peristaltic bag 102.

[0036] When the peristaltic bag 102 shrinks and deforms, the bottom of the peristaltic bag 102 rises due to the lifting of the lifting disturbance module 103, and the elastic bridge 305 is used to push the liquid inlet plug 303 to rise, first closing the bottom of the liquid inlet tube 302, thereby preventing the solution in the peristaltic bag 102 from being squeezed into the liquid inlet tube 302 in reverse, so that the solution in the peristaltic bag 102 is only squeezed into the liquid inlet tube 302. When the peristaltic bag 102 continues to deform, the elastic bridge 305 is used to elastically deform to buffer the subsequent impact of the deformation of the peristaltic bag 102 on the liquid inlet plug 303. After the peristaltic bag 102 recovers, the limiting rib 304 pushes the liquid inlet plug 303 away from the lower opening of the liquid inlet tube 302 again, so as to facilitate the replenishment of new solution into the peristaltic bag 102.

[0037] Figures 3 to 5As shown, a temporary storage tube segment 306 is fixedly connected to the top of the liquid inlet tube 302, and the diameter of the temporary storage tube segment 306 is larger than the diameter of the liquid inlet tube 302, and a communicating tube 307 is fixedly connected between the top of the temporary storage tube segment 306 and the top of the dissolution tube 101, and the communicating tube 307 corresponds to the overflow hole 301 in level, and the diameter of the temporary storage tube segment 306 is larger than the diameter of the liquid inlet tube 302, and the diameter of the communicating tube 307 is larger than the diameter of the overflow hole 301. When the solution rises in the dissolution tube 101 and overflows from the overflow hole 301, another part of the solution enters the temporary storage tube segment 306 from the communicating tube 307, thereby effectively increasing the total amount of solution rising, thereby effectively improving the flushing effect of the solution on the drug cage 106, and the solution in the temporary storage tube segment 306 subsequently returns to the peristaltic bag 102 to realize the circulation of the solution, thereby effectively improving the drug dissolution effect;

[0038] After the liquid inlet plug 303 seals the bottom of the liquid inlet tube 302, the solution in the peristaltic bag 102 is squeezed into the dissolving tube 101. While the solution overflows from the overflow hole 301, part of the solution also enters the temporary storage tube section 306 from the communicating tube 307 for storage. Figure 4 As shown, the stored solution will not immediately return to the peristaltic bag 102 due to the closure of the bottom of the liquid inlet tube 302. Due to the addition of the solution entering the temporary storage tube segment 306, the total amount of the solution rising in the dissolution tube 101 is increased, and the flushing effect of the solution on the drug cage 106 is effectively improved. When the peristaltic bag 102 is subsequently deformed and restored, the liquid inlet plug 303 reopens the bottom of the liquid inlet tube 302, and the solution in the temporary storage tube segment 306 returns to the peristaltic bag 102 through the liquid inlet tube 302, so that the solution circulates between the peristaltic bag 102, the liquid inlet tube 302 and the dissolution tube 101, effectively improving the dissolution and dispersion effect of the drug in the solution.

[0039] The second implementation method:

[0040] Compared with the first embodiment, this embodiment mainly adds a scraping module 4, and the specific newly added structure is as follows, and the remaining structures are consistent with the first embodiment.

[0041] Figure 2 and Figures 7 and 8As shown, the scraping module 4 is movably connected inside the drug cage 106, and the scraping module 4 contacts the tablet 2 to be tested. The scraping module 4 is used to scrape the tablet 2 to be tested. The scraping module 4 simulates the food coexisting with the tablet, which effectively improves the validity of the experimental test results. The top of the scraping module 4 is fixedly connected to the connecting rod 401, and the top of the connecting rod 401 extends to the overflow hole 301, and the top of the connecting rod 401 is fixedly connected to the floating module 402. The floating module 402 and the connecting rod 401 are used to realize the synchronous movement of the scraping module 4 following the lifting and lowering movement of the solution, which effectively improves the scraping effect of the scraping module 4 and the tablet 2 to be tested. The scraping module 4 is arranged in multiple layers, and each layer of the scraping module 4 is composed of cotton wool, glass fiber yarn and glass beads. The multi-layer scraping module 4 is composed of different materials, which effectively improves the complexity of the scraping effect of the tablet 2 to be tested.

[0042] When the solution moves up and down in the dissolving tube 101, the floating module 402 moves up and down due to the change of the liquid level of the solution, and the connecting rod 401 is used to drive the scraping module 4 to move up and down, so that the scraping module 4 scrapes the tablet 2 to be tested to simulate the scraping of food and tablets coexisting in the intestine. By setting up a multi-layer scraping module 4 to scrape the tablet 2 to be tested, and the layered scraping module 4 is composed of a combination of different materials, that is, cotton wool simulates thin food, glass fiber simulates dietary fiber in food, and glass beads simulate bones and seeds in food, the complexity of the scraping effect of the tablet 2 to be tested is effectively improved, thereby effectively improving the scraping effect of the tablet 2 to be tested.

[0043] Figure 7 and Figure 8 As shown, a medicine cage opening 403 is provided at the bottom end of the medicine cage 106, a closing plug 404 is inserted inside the medicine cage opening 403, and an umbrella support cover 405 is fixedly connected to the top of the closing plug 404. The tablet 2 to be tested is at the top of the umbrella support cover 405, and the layer gap of the scraping module 4 is correspondingly engaged with the outer edge of the umbrella support cover 405. The umbrella support cover 405 is made of elastic rubber material, and the tablet 2 to be tested is placed in the medicine cage 106 through the medicine cage opening 403, and the medicine cage opening 403 is quickly closed through the closing plug 404. At the same time, the lowest height of the tablet 2 to be tested in the medicine cage 106 is limited by the umbrella support cover 405, so as to effectively prevent the tablet 2 to be tested from sinking to the bottom of the medicine cage 106;

[0044] A medicine cage opening 403 is provided at the bottom of the medicine cage 106 to facilitate the insertion of the test tablet 2 into the medicine cage 106, and then the medicine cage opening 403 is closed by the closing plug 404, and the test tablet 2 in the medicine cage 106 is lifted by the umbrella support cover 405 to effectively prevent the test tablet 2 from sinking to the bottom of the medicine cage 106, thereby maintaining the scraping effect of the scraping module 4 on the test tablet 2, and the edge of the umbrella support cover 405 is plugged into the gap of each scraping module 4, and when the scraping module 4 moves up and down, the edge of the umbrella support cover 405 can switch between the gaps of different scraping modules 4.

[0045] In view of current practical needs, the above-mentioned implementation mode adopted in this application is not limited to the scope of protection. Various changes made within the knowledge scope of technical personnel in this field without departing from the concept of this application still fall within the scope of protection of the present invention.

Claims

1. A tablet dissolution release testing device, characterized in that: The device comprises a device tank body (1), wherein a dissolution tube (101) is fixedly connected to the top of the device tank body (1), a peristaltic bag (102) is fixedly connected to the bottom of the dissolution tube (101), a lifting disturbance module (103) is fixedly connected to the bottom of the device tank body (1), the top of the lifting disturbance module (103) is fixedly connected to the middle of the bottom end of the peristaltic bag (102), a drug cage (106) is placed inside the dissolution tube (101), a tablet to be tested (2) is placed inside the drug cage (106), the drug cage (106) is located at the connection between the dissolution tube (101) and the peristaltic bag (102), and a support rod (105) is fixedly connected to the top of the drug cage (106), a pipe plug (104) is fixedly connected to the top of the dissolution tube (101), and the pipe plug (104) is plugged into the top of the dissolution tube (101); The top of the dissolving tube (101) is fixedly connected to an overflow hopper (3), an overflow hole (301) is provided between the overflow hopper (3) and the top of the dissolving tube (101), a liquid inlet pipe (302) is fixedly connected to one end of the top of the equipment tank body (1), the bottom end of the liquid inlet pipe (302) is communicated with the top of the peristaltic bag (102), and the top height of the liquid inlet pipe (302) is greater than the height of the overflow hopper (3), a liquid inlet plug (303) is inserted into the bottom of the liquid inlet pipe (302), a limiting rib (304) is fixedly connected between the top of the liquid inlet plug (303) and the lower opening of the liquid inlet pipe (302), and the bottom of the liquid inlet plug (303) is connected to the peristaltic bag ( An elastic bridge (305) is fixedly connected between the middle of the bottom end of the liquid inlet pipe (302), a temporary storage pipe section (306) is fixedly connected to the top of the liquid inlet pipe (302), a communicating pipe (307) is fixedly connected between the top of the temporary storage pipe section (306) and the top of the dissolving pipe (101), the communicating pipe (307) corresponds horizontally to the overflow hole (301), the diameter of the temporary storage pipe section (306) is larger than the diameter of the liquid inlet pipe (302), the diameter of the communicating pipe (307) is larger than the diameter of the overflow hole (301), the limiting rib (304) is bent in a U shape, and the limiting rib (304) is made of elastic rubber material, and the elastic bridge (305) is made of spring steel.

2. A tablet dissolution release testing device according to claim 1, characterized in that: The bottom of the peristaltic bag (102) is arranged in a conical shape, and a counterweight ring (107) is placed outside the conical bottom of the peristaltic bag (102). The peristaltic bag (102) is made of a wear-resistant rubber material, and the counterweight ring (107) is made of a stainless steel material.

3. A tablet dissolution release testing device according to claim 1, characterized in that: The interior of the drug cage (106) is movably connected to a scraping module (4), and the scraping module (4) is in contact with the tablet (2) to be tested.

4. A tablet dissolution release testing device according to claim 3, characterized in that: The top of the scraping module (4) is fixedly connected to a connecting rod (401), the top of the connecting rod (401) extends to the overflow hole (301), and the top of the connecting rod (401) is fixedly connected to a floating module (402).

5. The tablet dissolution release testing device according to claim 3, characterized in that: The scraping modules (4) are arranged in multiple layers, and the scraping modules (4) of each layer are composed of a combination of cotton wool, glass fiber yarns and glass beads.

6. A tablet dissolution release testing device according to claim 3, characterized in that: The bottom end of the drug cage (106) is provided with a drug cage opening (403), a sealing plug (404) is inserted into the interior of the drug cage opening (403), an umbrella support cover (405) is fixedly connected to the top of the sealing plug (404), the drug tablet (2) to be tested is located on the top of the umbrella support cover (405), the layer gap of the scraping module (4) is snap-fitted to the outer edge of the umbrella support cover (405), and the umbrella support cover (405) is made of elastic rubber material.

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