Inhalation type drug rehabilitation and addiction removal traditional Chinese medicine combination preparation and preparation method and administration device thereof

Abstract

The invention provides an inhalation type drug rehabilitation and addiction removal traditional Chinese medicine combination preparation and a preparation method and an administration device thereof. The inhalation type drug rehabilitation and addiction removal traditional Chinese medicine combination preparation is sucked by adopting a heating type administration device and comprises a drug rehabilitation and addiction removal traditional Chinese medicine composition and a suction nozzle filter element composition. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 3-14 parts of astragalus membranaceus, 2-9 parts of spina date seed, 1-9 parts of schisandra chinensis, 15-35 parts of corydalis tuber, 2-8 parts of liquorice, 1-6 parts of ginseng and 2-8 parts of bighead atractylodes rhizome. The suction nozzle filter element composition comprises the following raw materials in parts by weight: 4-13 parts of gypsum, 3-9 parts of artemisia apiacea, 5-14 parts of corn stigma and 18-26 parts of plant charcoal. The inhalation type drug rehabilitation and addiction removal traditional Chinese medicine combination preparation not only can be matched with a drug rehabilitation place for early detoxification, but also can be used as an auxiliary drug for later addiction removal, so that thorough drug rehabilitation success is realized. The inhalation type drug rehabilitation and addiction removal traditional Chinese medicine combination preparation does not burn after being heated, and the low-carbon and environment-friendly drug rehabilitation function can be fundamentally achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for drug addiction treatment, and more particularly to an inhalable traditional Chinese medicine combination formulation for drug addiction treatment, a preparation method thereof, and a drug delivery device. Background Art

[0002] According to relevant data, the number of drug addicts in the world has reached more than 200 million, and more than one million people die from drug abuse every year. Drug abuse not only causes losses to the national economy, but also brings serious negative impacts to families and society.

[0003] At present, various methods of drug rehabilitation are numerous. Most of them are compulsory means in drug rehabilitation centers, and they are controlled by injection of various chemical drugs. However, this method is very easy to cause damage to the human body. Since this method is very harmful to the human body, it is generally only a short-term treatment. For morphine drug addicts, it only achieves early detoxification (anti-withdrawal symptoms), but cannot completely achieve late detoxification (preventing and treating relapse), that is, it is only detoxification but not detoxification. It is easy to relapse after the detoxification period, although naltrexone is currently used as an auxiliary drug for opioid addicts after withdrawal. Most opioid addicts have prolonged symptoms after withdrawal (such as persistent blindness, irritability, anxiety, pain in muscles, bones and joints throughout the body, loss of appetite, and general discomfort), which make the patients suffer unbearable pain and difficulty in extricating themselves. Naltrexone cannot alleviate such symptoms and cannot solve the patients' unbearable pain and difficulty in extricating themselves. For those with weak wills who want to quit drugs and get rid of addiction but also want to take drugs again, if they relapse once, it will be very dangerous to use naltrexone to get rid of addiction again. There are not many drug addicts with strong wills, so it is difficult to implement detoxification with naltrexone.

[0004] Traditional Chinese medicine has a long history in my country, and using traditional Chinese medicine to relieve drug withdrawal symptoms has become a major trend. It is currently being promoted and applied in some drug rehabilitation centers, but the treatment cycle is long and the effect is not good. Summary of the invention

[0005] Based on the above problems, the purpose of the present invention is to provide an inhalable Chinese medicine combination preparation for drug addiction treatment and its preparation method, as well as a drug delivery device. The inhalable Chinese medicine combination preparation for drug addiction treatment of the present invention can not only cooperate with drug rehabilitation centers for early detoxification, but also can be used as an auxiliary drug for late detoxification, thereby achieving complete drug addiction treatment success.

[0006] To achieve the above-mentioned purpose, the first aspect of the present invention provides an inhalable Chinese medicine combination formulation for drug addiction treatment, which is sucked by a heated drug administration device, including a Chinese medicine composition for drug addiction treatment and a nozzle filter element composition. The raw materials of the Chinese medicine composition for drug addiction treatment include 3 to 14 parts of astragalus, 2 to 9 parts of spinach seeds, 1 to 9 parts of schisandra, 15 to 35 parts of corydalis, 2 to 8 parts of liquorice, 1 to 6 parts of ginseng and 2 to 8 parts of atractylodes, and the raw materials of the nozzle filter element composition include 4 to 13 parts of gypsum, 3 to 9 parts of artemisia annua, 5 to 14 parts of corn silk and 18 to 26 parts of plant charcoal.

[0007] In the technical solution adopted by the present invention, the inhalation-type Chinese medicine combination for drug addiction treatment includes a Chinese medicine composition for drug addiction treatment and a mouthpiece filter element composition, which is inhaled by a heated drug delivery device, similar to the method of an electronic cigarette. Therefore, compared with the injection of chemical drugs, it causes less damage to the human body in the early detoxification stage, and also increases the initiative of use in the later detoxification stage, so that patients are willing to use it for a long time. The active ingredients of the Chinese medicine composition for drug addiction treatment enter the patient's blood through alveolar absorption by suction, thereby acting on the patient's whole body, which is equivalent to the effect of detoxification and detoxification of pills, injections, etc., and has better effect.

[0008] The inhalable Chinese medicine combination preparation for drug addiction treatment of the present invention is used in combination with a Chinese medicine composition for drug addiction treatment and a mouthpiece filter element composition. The Chinese medicine composition for drug addiction treatment is heated in a heated drug delivery device to produce active volatiles to achieve drug addiction treatment. The mouthpiece filter element composition removes odor from the gas produced in the heated drug delivery device and prevents high-temperature active volatiles from affecting the patient's alveoli and thus affecting the efficacy of the medicine.

[0009] The inhalable drug-detoxification and addiction-relief Chinese medicine combination preparation of the present invention can be heated without burning, and can fundamentally achieve a low-carbon, green and environmentally friendly drug-detoxification function.

[0010] As a technical solution of the present invention, the raw materials of the Chinese medicine composition for drug addiction treatment include 4 to 12 parts of astragalus, 4 to 7 parts of spinach seed, 3 to 7 parts of schisandra, 18 to 30 parts of corydalis, 3 to 8 parts of liquorice, 2 to 6 parts of ginseng and 2 to 6 parts of atractylodes.

[0011] As a technical solution of the present invention, the raw materials of the Chinese medicine composition for drug addiction treatment include 4 to 8 parts of astragalus, 5 to 6 parts of spinach seed, 4 to 6 parts of schisandra, 20 to 27 parts of corydalis, 3 to 6 parts of liquorice, 2 to 5 parts of ginseng and 3 to 5 parts of atractylodes.

[0012] As a technical solution of the present invention, the raw materials of the Chinese medicine composition for drug addiction treatment include 5 to 7 parts of astragalus, 6 parts of spinach seed, 5 parts of schisandra, 20 to 23 parts of corydalis, 5 parts of liquorice, 2 to 4 parts of ginseng and 4 parts of atractylodes.

[0013] As a technical solution of the present invention, the nozzle filter element composition includes 4 to 10 parts of gypsum, 3 to 7 parts of Artemisia annua, 8 to 14 parts of corn silk and 20 to 26 parts of plant charcoal.

[0014] As a technical solution of the present invention, the nozzle filter element composition includes 6 to 9 parts of gypsum, 3 to 5 parts of Artemisia annua, 8 to 12 parts of corn silk and 20 to 23 parts of plant charcoal.

[0015] As a technical solution of the present invention, the nozzle filter element composition includes 7 to 8 parts of gypsum, 4 parts of Artemisia annua, 8 to 10 parts of corn silk and 22 parts of plant charcoal.

[0016] The second aspect of the present invention provides a method for preparing an inhalable Chinese medicine combination formulation for drug addiction treatment, comprising the steps of:

[0017] (1) Preparation of Chinese medicine composition for drug addiction treatment

[0018] The spiny jujube seeds, the schisandra chinensis, the corydalis yanhusuo and part of the liquorice are mixed, soaked and boiled, and the filtrate is filtered to be concentrated to a paste to obtain an extract, the astragalus, the ginseng, the atractylodes macrocephala and the remaining liquorice are washed, dried and crushed, and the crushed material is mixed with the extract, pressed and sliced ​​into medicinal threads;

[0019] (2) Nozzle filter composition

[0020] The artemisia annua is washed, dried and chopped; the corn silk is cut into sections, dried and crushed; the raw gypsum, the plant charcoal, the processed artemisia annua and the processed corn silk are sieved, fully mixed and sterilized; white wine is added to mix to obtain a semi-loose mixture; the mixture is dried to semi-dry for granulation and dried to obtain a filter element.

[0021] The preparation method of the present invention is based on the characteristics of each raw material, firstly making an extract and then mixing it with the crushed raw material to make medicinal silk to obtain a drug addiction treatment Chinese medicine composition. The characteristics of each raw material of the drug addiction treatment Chinese medicine composition are pre-processed and then granulated to obtain a filter element. The active components of each raw material can be greatly exerted by processing in a specific way.

[0022] The third aspect of the present invention provides a drug delivery device, comprising a shell provided with a carrying cavity, a heating device and a suction nozzle piece connected to the carrying cavity, one end of the suction nozzle piece is connected to the carrying cavity, and the other end of the suction nozzle piece is exposed to the shell, the carrying cavity carries the drug addiction treatment and detoxification Chinese medicine composition in the aforementioned inhalable drug addiction treatment and detoxification Chinese medicine combination formulation, the heating device is used to heat the drug addiction treatment and detoxification Chinese medicine composition in the carrying cavity to produce active volatiles, and the suction nozzle piece is filled with the suction nozzle filter element composition in the aforementioned inhalable drug addiction treatment and detoxification Chinese medicine combination formulation.

[0023] In the drug delivery device of the present invention, the Chinese medicine composition for drug addiction treatment in the bearing cavity generates gas after heating, and such gas includes not only active volatiles but also pungent odors that are irritating to the nose, and the temperature of the gas is relatively high after heating. The high-temperature gas with pungent odor enters the patient's nasal cavity and oral cavity through the mouthpiece, which will irritate the oral mucosa, nasal mucosa and alveoli, thereby affecting the efficacy of the drug, and will also reduce the patient's initiative to use the drug delivery device. By filling the mouthpiece with a mouthpiece filter element composition, this filter element can not only reduce the temperature of the gas and absorb pungent odors, but the composition contained therein can also reduce the high temperature effect of the high-temperature gas on the oral mucosa, nasal mucosa and alveoli. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 FIG. 4 is a schematic diagram of a drug delivery device according to the present invention. DETAILED DESCRIPTION

[0025] The present invention provides an inhalable Chinese medicine combination formulation for drug addiction treatment and a preparation method thereof, and also provides a drug delivery device used in combination with the inhalable Chinese medicine combination formulation for drug addiction treatment.

[0026] The drug delivery device of the present invention is a suction-type structure, which can be used as Figure 1 In the structure shown, the drug delivery device 100 includes a shell 10 provided with a bearing cavity 11, a heating device 30 and a mouthpiece 50 connected to the bearing cavity 11. One end of the mouthpiece 50 is connected to the bearing cavity 11, and the other end of the mouthpiece 50 is exposed to the shell 10. The bearing cavity 11 carries a Chinese medicine composition 70 for drug addiction treatment, and the heating device 30 is used to heat the Chinese medicine composition 70 for drug addiction treatment in the bearing cavity 11 to produce active volatiles, and the mouthpiece 50 is filled with a mouthpiece filter element composition 90. The heating temperature of the heating device 30 should not be too high, otherwise the gas generated will be too high. The heating temperature of the heating device 30 is preferably 300-400°C. When in use, the drug addiction treatment and detoxification Chinese medicine composition 70 is placed in the carrying cavity 11, the suction nozzle piece 50 is filled with the suction nozzle filter element composition 90, the drug addiction treatment and detoxification Chinese medicine composition 70 is heated to generate volatile gas, and the patient uses the suction nozzle piece 50 to inhale the active volatile substances of the drug addiction treatment and detoxification Chinese medicine composition 70 that flow out from the carrying cavity 11 and are absorbed and cooled by the suction nozzle filter element composition 90.

[0027] The Chinese medicine combination preparation for drug addiction treatment includes a Chinese medicine composition for drug addiction treatment and a mouthpiece filter element composition. The preparation of the Chinese medicine composition for drug addiction treatment includes: mixing, soaking, boiling, filtering, and concentrating the filtrate to a paste to obtain an extract, washing, drying, and crushing the astragalus, ginseng, atractylodes, and the remaining licorice, and mixing the crushed material with the extract, pressing, and slicing into medicinal threads. The soaking time can be 1 to 2 hours, and the boiling time can be 1 to 2 hours.

[0028] The preparation of the suction nozzle filter element composite comprises: washing, drying and chopping the sweet wormwood; cutting into sections, drying and crushing corn silk; sieving gypsum, plant charcoal, processed sweet wormwood and processed corn silk, fully mixing and disinfecting; adding white wine and mixing to obtain a semi-loose mixture; drying to semi-dry for granulation and drying to obtain the filter element.

[0029] Calculated by weight, the raw materials of the Chinese medicinal composition for drug addiction treatment include 3 to 14 parts of astragalus, 2 to 9 parts of spinach seed, 1 to 9 parts of schisandra chinensis, 15 to 35 parts of corydalis, 2 to 8 parts of liquorice, 1 to 6 parts of ginseng and 2 to 8 parts of atractylodes.

[0030] The weight proportion of Radix Astragali can be but not limited to 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts. The active ingredients produced by the heating of Radix Astragali mainly include astragaloside, flavonoids, astragaloside polysaccharide, alkaloids, gamma-aminobutyric acid, which is a kind of inhibitory neurotransmitter, has the effects of analgesia, antianxiety, anti-cardiac rhythm, decompression, anticonvulsant, and can carry out early detoxification and effectively treat protracted symptoms. In addition, astragaloside, flavonoids, astragaloside polysaccharide, alkaloids have anti-inflammatory and immunomodulation, organ protection, antiviral, hypoglycemic, improve insulin resistance activity, anti-tumor and other biological activities, which can solve the effects of removing residual poison, supporting positive energy, and strengthening physical fitness after detoxification, to prevent relapse.

[0031] The weight proportion of Semen Ziziphi Spinosae can be but not limited to 2, 3, 4, 5, 6, 7, 8, 9. The active ingredients produced by Semen Ziziphi Spinosae through heating mainly include Semen Ziziphi Spinosae Saponins and flavonoids, which can be used to treat insomnia and alleviate the protracted symptoms after withdrawal. In addition, the active ingredients of Semen Ziziphi Spinosae also have the function of enhancing the transmission of gamma-aminobutyric acid in central nervous cells, producing sedative, hypnotic, antianxiety, antidepressant effects.

[0032] The weight proportion of Schisandrae Chinensis can be but not limited to 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts. Schisandrae Chinensis has the effects of astringing, strengthening qi and promoting the production of body fluid, tonifying the kidney and calming the mind, can enhance the overall physique of the patient, and is conducive to enhancing the patient's will. In addition, Schisandrae Chinensis can produce active ingredient lignans after heating, and lignans are powerful antioxidants that can inhibit free radicals and increase the level of antioxidant-glutathione in the liver. Schisandrae Chinensis can activate the nervous system, promote reaction ability, mental concentration and coordination, and enhance clear thinking. Although it has the effect of activation, it does not have the side effect of caffeine anxiety. Although it can improve the irritability in the protracted symptoms, it will not be to make the patient dependent.

[0033] The weight proportion of Corydalis yanhusuo can be, but is not limited to, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35. Corydalis yanhusuo produces active ingredient LTHP after heating. LTHP has analgesic, sedative and tranquilizing effects, and synergistically acts with gamma-aminobutyric acid, an active ingredient of Astragalus membranaceus, and is used for early detoxification. The structure of the active ingredient of Corydalis yanhusuo is similar to that of opioids, but it is not addictive and can be used for drug rehabilitation.

[0034] The weight proportion of licorice can be, but is not limited to, 2, 3, 4, 5, 6, 7, or 8. Licorice has the functions of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving pain, and harmonizing various medicines. Its characteristics can effectively regulate the toxicity and potency of drugs.

[0035] The weight proportion of ginseng can be, but is not limited to, 1, 2, 3, 4, 5, or 6. Ginseng can enhance immunity, delay aging, and protect the liver. When used in combination with Schisandra chinensis, it can replenish vital energy and restore yang to consolidate deficiency.

[0036] The weight proportion of Atractylodes macrocephala can be, but is not limited to, 2, 3, 4, 5, 6, 7, or 8. Atractylodes macrocephala can invigorate Qi and strengthen the spleen, and has the effects of consolidating the exterior and stopping the symptoms. In addition, the active ingredient Atractylodes macrocephala polysaccharide produced by heating Atractylodes macrocephala has the effect of enhancing the body's immune function and can improve the patient's cellular immune function.

[0037] The raw materials of the suction nozzle filter element composition include 4 to 13 parts of gypsum, 3 to 9 parts of sweet wormwood, 5 to 14 parts of corn silk and 18 to 26 parts of plant charcoal.

[0038] The weight proportion of raw gypsum can be, but not limited to, 4, 5, 6, 7, 8, 9, 10, 11, 12, and 13. The weight proportion of Artemisia annua can be, but not limited to, 3, 4, 5, 6, 7, 8, and 9. The weight proportion of corn silk can be, but not limited to, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14. The weight proportion of plant charcoal can be, but not limited to, 18, 19, 20, 21, 22, 23, 24, 25, and 26. Raw gypsum has the effects of clearing away heat and purging fire, eliminating restlessness and quenching thirst, clearing away heat and detoxifying, collecting dampness and astringing sores, promoting tissue regeneration and astringing sores, relieving muscle and clearing heat. Artemisia annua has the effects of clearing away heat from deficiency, relieving summer heat, resisting pathogenic microorganisms, and regulating immunity. The active molecules of gypsum and Artemisia annua can flow into the patient's body along with the high-temperature gas, thereby alleviating the impact of the high-temperature gas on the alveoli. Corn silk has a laxative effect. After the patient inhales through the mouthpiece, corn silk can improve the circulation of active ingredients in the patient's body. Plant charcoal is mainly used as the source of the filter element matrix. In addition, plant charcoal has a strong adsorption effect and can effectively remove odors and harmful substances in the gas generated by heating.

[0039] In order to better illustrate the purpose, technical scheme and beneficial effects of the present invention, the present invention will be further described below in conjunction with specific embodiments. It should be noted that the following implementation method is a further explanation of the present invention and should not be used as a limitation of the present invention.

[0040] Example 1

[0041] This embodiment is an inhalable Chinese medicine combination for drug addiction treatment, including a Chinese medicine composition for drug addiction treatment and a mouthpiece filter element composition. In terms of weight fraction, the raw materials of the Chinese medicine composition for drug addiction treatment include 6 parts of Astragalus, 6 parts of Semen Ziziphi Spinosae, 5 parts of Schisandrae Chinensis, 21 parts of Corydalis, 5 parts of Licorice, 3 parts of Ginseng and 4 parts of Atractylodes. The raw materials of the mouthpiece filter element composition include 7 parts of Gypsum, 4 parts of Artemisia annua, 9 parts of Corn Silk and 22 parts of Plant Charcoal.

[0042] Example 2

[0043] This embodiment is an inhalable Chinese medicine combination for drug addiction treatment, including a Chinese medicine composition for drug addiction treatment and a mouthpiece filter element composition. In terms of weight fraction, the raw materials of the Chinese medicine composition for drug addiction treatment include 10 parts of astragalus, 8 parts of spiny jujube seeds, 7 parts of schisandra chinensis, 30 parts of corydalis, 3 parts of liquorice, 2 parts of ginseng and 6 parts of atractylodes. The raw materials of the mouthpiece filter element composition include 10 parts of gypsum, 8 parts of artemisia annua, 13 parts of corn silk and 26 parts of plant charcoal.

[0044] Example 3

[0045] This embodiment is an inhalable Chinese medicine combination for drug addiction treatment, including a Chinese medicine composition for drug addiction treatment and a mouthpiece filter element composition. In terms of weight fraction, the raw materials of the Chinese medicine composition for drug addiction treatment include 3 parts of Astragalus, 4 parts of Ziziphus jujuba seeds, 9 parts of Schisandra chinensis, 18 parts of Corydalis, 2 parts of Licorice, 6 parts of Ginseng and 8 parts of Atractylodes macrocephala. The raw materials of the mouthpiece filter element composition include 12 parts of Gypsum, 8 parts of Artemisia annua, 5 parts of Corn Silk and 19 parts of Plant Charcoal.

[0046] Example 4

[0047] This embodiment is an inhalable Chinese medicine combination for drug addiction treatment, including a Chinese medicine composition for drug addiction treatment and a mouthpiece filter element composition. In terms of weight fraction, the raw materials of the Chinese medicine composition for drug addiction treatment include 12 parts of Astragalus, 9 parts of Semen Ziziphi Spinosae, 3 parts of Schisandrae Chinensis, 30 parts of Corydalis, 8 parts of Licorice, 5 parts of Ginseng and 7 parts of Atractylodes. The raw materials of the mouthpiece filter element composition include 4 parts of Gypsum, 8 parts of Artemisia annua, 13 parts of Corn Silk and 23 parts of Plant Charcoal.

[0048] The preparation method of the inhalable drug addiction treatment Chinese medicine combination formulation of Examples 1 to 4 may include the following steps.

[0049] (1) Preparation of Chinese medicine composition for drug addiction treatment

[0050] Mix the Chinese jujube seeds, Schisandra chinensis, the Corydalis yanhusuo and half of the liquorice, soak for 1 hour, add the same water and boil for 1 hour, then filter and concentrate the filtrate to a paste to obtain an extract, wash the Astragalus, ginseng, Atractylodes macrocephala and the remaining liquorice, dry and crush, mix the crushed material with the extract, press and slice into medicinal threads.

[0051] (2) Nozzle filter composition

[0052] Wash, dry and chop the Artemisia annua; cut corn silk into sections, dry and crush; sieve gypsum, plant charcoal, processed Artemisia annua and processed corn silk, mix them thoroughly and sterilize them; then add white wine to mix to obtain a semi-loose mixture; dry until semi-dry to granulate and dry to obtain a filter element.

[0053] The inhalation-type Chinese medicine combination formulations for drug addiction treatment of Examples 1 to 4 were used in a drug administration device to conduct clinical trials on some drug addicts in a drug rehabilitation center in Maoming City, Guangdong, a drug rehabilitation center in Chenzhou City, Hunan, a drug rehabilitation center in Huaihua City, Hunan, and a drug rehabilitation center in Jiangmen City, Guangdong. The specific process is as follows.

[0054] (1) Test subjects

[0055] ① A drug rehabilitation center in Maoming City, Guangdong

[0056] A total of 100 cases from a drug rehabilitation center in Maoming City, Guangdong Province were randomly selected, with 70 cases in the treatment group, 70 cases in the control group 1, and 30 cases in the control group 2.

[0057] Treatment group: 50 males and 20 females. Age: 50 years old, 18 years old, average age 25.4 years old. Occupation: 39 people without fixed occupation, 10 people doing manual labor, 21 people doing non-manual labor. Drug use method: 5 people smoking, 10 people scalding, 35 people injecting, 20 people using drugs together. Years of drug use: 10 people ≥10 years, 32 people ≥5 years, 15 people ≥2 years, 5 people ≥1 year, 8 people ≥6 months.

[0058] Control group 1: 48 males and 22 females. Age: the oldest was 51 years old, the youngest was 18, and the average age was 25.9 years old. Occupation: 33 people had no fixed occupation, 15 people were manual laborers, and 22 people were non-manual laborers. Drug use methods: 7 people smoked, 15 people scalded, 30 people injected, and 18 people used drugs together. Years of drug use: 13 people had ≥10 years, 30 people had ≥5 years, 17 people had ≥2 years, 5 people had ≥1 year, and 5 people had ≥6 months.

[0059] Control group 2: 22 males and 8 females. Age: the oldest was 54 years old, the youngest was 19, and the average age was 25.9 years old. Occupation: 18 people had no fixed occupation, 3 people were manual laborers, and 9 people were non-manual laborers. Drug use methods: 2 people smoked, 5 people scalded, 18 people injected, and 5 people used drugs together. Years of drug use: 1 person had ≥10 years, 11 people had ≥5 years, 13 people had ≥2 years, 3 people had ≥1 year, and 2 people had ≥6 months.

[0060] In addition, the average main symptom score of the treatment group before treatment was 19.79±2.73, the average main symptom score of the control group 1 before treatment was 19.73±2.87, and the average main symptom score of the control group 2 before treatment was 19.58±4.03. There was little difference between the three, indicating that there was no significant difference in the severity of the disease among the three groups before treatment, and they were comparable.

[0061] ② A drug rehabilitation center in Chenzhou City, Hunan Province

[0062] A total of 120 cases from a drug rehabilitation center in Chenzhou City, Hunan Province were randomly selected, with 80 cases in the treatment group, 80 cases in the control group 1, and 40 cases in the control group 2.

[0063] Treatment group: 55 males and 25 females. Age: the oldest was 57 years old, the youngest was 19, and the average age was 26.5 years old. Occupation: 48 people had no fixed occupation, 15 people were manual laborers, and 17 people were non-manual laborers. Drug use methods: 7 people smoked, 13 people scalded, 40 people injected, and 20 people used drugs together. Years of drug use: 14 people had ≥10 years, 35 people had ≥5 years, 16 people had ≥2 years, 5 people had ≥1 year, and 10 people had ≥6 months.

[0064] Control group 1: 50 males and 30 females. Age: the oldest was 59 years old, the youngest was 19, and the average age was 27.4 years old. Occupation: 52 people had no fixed occupation, 10 people were manual laborers, and 18 people were non-manual laborers. Drug use methods: 10 people smoked, 15 people scalded, 35 people injected, and 20 people used drugs together. Years of drug use: 18 people had ≥10 years, 32 people had ≥5 years, 15 people had ≥2 years, 6 people had ≥1 year, and 9 people had ≥6 months.

[0065] Control group 2: 30 males and 10 females. Age: the oldest was 56 years old, the youngest was 17, and the average age was 28.8 years old. Occupation: 25 people without fixed occupations, 4 people doing manual labor, and 11 people doing non-manual labor. Drug use methods: 3 people smoking, 10 people scalding, 20 people injecting, and 7 people using drugs together. Years of drug use: 2 people ≥10 years, 18 people ≥5 years, 14 people ≥2 years, 3 people ≥1 year, and 3 people ≥6 months.

[0066] In addition, the average main symptom score of the treatment group before treatment was 20.79±3.70, the average main symptom score of the control group 2 before treatment was 20.34±4.21, and the average main symptom score of the control group 2 before treatment was 21.01±2.08. There was little difference between the three, indicating that there was no significant difference in the severity of the disease among the three groups before treatment and they were comparable.

[0067] ③A drug rehabilitation center in Huaihua City, Hunan Province

[0068] A total of 150 cases from a drug rehabilitation center in Huaihua City, Hunan Province were randomly selected, with 110 cases in the treatment group, 110 cases in the control group 1, and 40 cases in the control group 2.

[0069] Treatment group: 78 males and 32 females. Age: the oldest is 60 years old, the youngest is 17, and the average age is 27.3 years old. Occupation: 75 people without fixed jobs, 17 people doing manual labor, and 18 people doing non-manual labor. Drug use methods: 12 people smoking, 18 people scalding, 55 people injecting, and 25 people using drugs together. Years of drug use: 27 people ≥10 years, 43 people ≥5 years, 25 people ≥2 years, 7 people ≥1 year, and 8 people ≥6 months.

[0070] Control group 1: 80 males and 30 females. Age: the oldest was 58 years old, the youngest was 19, and the average age was 27.8 years old. Occupation: 80 people without fixed occupations, 15 people doing manual labor, and 15 people doing non-manual labor. Drug use methods: 10 people smoking, 22 people scalding, 50 people injecting, and 28 people using drugs together. Years of drug use: 30 people ≥10 years, 40 people ≥5 years, 20 people ≥2 years, 8 people ≥1 year, and 12 people ≥6 months.

[0071] Control group 2: 28 males and 12 females. Age: the oldest was 52 years old, the youngest was 20, and the average age was 26.1 years old. Occupation: 20 people had no fixed occupation, 8 people were manual laborers, and 12 people were non-manual laborers. Drug use methods: 2 people smoked, 14 people scalded, 19 people injected, and 5 people used drugs together. Years of drug use: 3 people had ≥10 years, 15 people had ≥5 years, 15 people had ≥2 years, 3 people had ≥1 year, and 4 people had ≥6 months.

[0072] In addition, the average main symptom score of the treatment group before treatment was 24.03±3.21, the average main symptom score of the control group 1 before treatment was 23.69±3.10, and the average main symptom score of the control group 2 before treatment was 23.89±2.78. There was little difference between the three, indicating that there was no significant difference in the severity of the disease among the three groups before treatment and they were comparable.

[0073] ④ A drug rehabilitation center in Jiangmen City, Guangdong

[0074] A total of 110 cases from a drug rehabilitation center in Jiangmen City, Guangdong Province were randomly selected, with 80 cases in the treatment group, 80 cases in the control group 1, and 30 cases in the control group 2.

[0075] Treatment group: 59 males and 21 females. Age: the oldest was 54 years old, the youngest was 17, and the average age was 26.6 years old. Occupation: 58 people had no fixed occupation, 10 people were manual laborers, and 12 people were non-manual laborers. Drug use methods: 5 people smoked, 17 people scalded, 40 people injected, and 18 people used drugs together. Years of drug use: 18 people had ≥10 years, 30 people had ≥5 years, 18 people had ≥2 years, 4 people had ≥1 year, and 10 people had ≥6 months.

[0076] Control group 1: 55 males and 25 females. Age: the oldest was 57 years old, the youngest was 18, and the average age was 25.1 years old. Occupation: 45 people without fixed occupations, 10 people doing manual labor, and 25 people doing non-manual labor. Drug use methods: 8 people smoking, 20 people scalding, 32 people injecting, and 20 people using drugs together. Years of drug use: 15 people ≥10 years, 35 people ≥5 years, 15 people ≥2 years, 10 people ≥1 year, and 5 people ≥6 months.

[0077] Control group 2: 20 males and 10 females. Age: the oldest was 54 years old, the youngest was 19, and the average age was 24.9 years old. Occupation: 18 people without fixed jobs, 5 people doing manual labor, and 7 people doing non-manual labor. Drug use methods: 2 people smoking, 10 people scalding, 10 people injecting, and 8 people using drugs together. Years of drug use: 3 people ≥10 years, 10 people ≥5 years, 13 people ≥2 years, and 4 people ≥1 year.

[0078] In addition, the average main symptom score of the treatment group before treatment was 20.45±2.19, the average main symptom score of the control group 1 before treatment was 20.38±2.87, and the average main symptom score of the control group 2 before treatment was 20.19±3.05. There was little difference between the three, indicating that there was no significant difference in the severity of the disease among the three groups before treatment, and they were comparable.

[0079] (2) Symptoms of drug users

[0080] ① Selection of observation objects

[0081] Patients with heroin withdrawal syndrome were selected, who were addicted to heroin abuse and had withdrawal symptoms after drug withdrawal. The diagnostic criteria for withdrawal syndrome were established with reference to the relevant contents of the "Chinese Classification and Diagnostic Criteria for Mental Disorders" (CCMD-II-R) as follows:

[0082] (i) A history of dependence on psychoactive substances (such as heroin);

[0083] (ii) At least three of the following psychiatric symptoms occur after discontinuation or reduction of use of the addictive substance: mood changes such as anxiety, depression, restlessness, irritability, etc.; impaired consciousness; insomnia; fatigue; motor excitement or inhibition; inattention; memory loss; hallucinations or illusions; delusions.

[0084] (iii) accompanied by at least two of the following physical symptoms and signs: nausea and vomiting; muscle and body pain; pupil changes; runny nose or watery eyes or yawning; abdominal pain, diarrhoea; feeling of heat or fever; severe malaise; convulsions.

[0085] (iv) The nature and severity of the symptoms depend on the type and dose of the psychotropic substance, and the withdrawal syndrome can be rapidly resolved by reintroduction of the substance in appropriate amounts.

[0086] ②Inclusion criteria

[0087] (i) has smoked or injected drugs for more than 30 days and needs to use drugs every day;

[0088] (ii) psychological or physical dependence on drugs;

[0089] (iii) acute withdrawal syndrome that occurs 1 to 3 hours after stopping drug use or withdrawal symptoms such as tearing, sneezing, runny nose, yawning, chills, fever, goose bumps, headache, muscle and bone pain, abdominal pain, diarrhea, or nausea, vomiting, excessive sputum, insomnia, etc. that persist after three days of drug abstinence;

[0090] (iv) aged between 16 and 60;

[0091] (v) Opioids may be detected in urine (or blood).

[0092] ③Exclusion criteria

[0093] (i) Those who do not meet the inclusion criteria;

[0094] (ii) persons aged under 16 or over 60;

[0095] (iii) due to existing or concurrent serious illnesses caused by drug abuse, such as serious heart disease, liver or kidney damage, serious digestive system disease, serious blood disease, etc.;

[0096] (iv) persons who are severely malnourished;

[0097] (v) those with diastolic blood pressure lower than 7 kPa before treatment;

[0098] (vi) Those who are poisoned by drug overdose or have impaired consciousness due to drug abuse;

[0099] (vii) Those who do not cooperate with drug rehabilitation and have aggressive behavior or those who have impaired consciousness or convulsions during drug rehabilitation (before smoking the product of the present invention);

[0100] (viii) pregnant and lactating women;

[0101] (ix) Those with a history of neurological or mental illness;

[0102] (x) Failure to puff according to regulations, compliance below 80%, inability to judge efficacy, or incomplete data that affects safety, efficacy or taste.

[0103] ④Criteria for exclusion of cases:

[0104] (i) If a person is found to be secretly taking heroin during treatment;

[0105] (ii) Those who need to withdraw from treatment due to factors not related to the product of the present invention (such as self-injury, tuberculosis, viral hepatitis, etc.);

[0106] (iii) Patients who discontinue treatment due to severe adverse reactions after inhaling the product of the present invention and whose efficacy cannot be assessed will not be included in the efficacy assessment but will be included in the safety assessment.

[0107] (3) Observation indicators

[0108] ① Safety observation

[0109] (i) Clinical symptoms: unexpected clinical symptoms that occur after the smoker smokes the product of the present invention;

[0110] (ii) Physical examination: including examination of pulse, respiration, blood pressure, skin, heart rhythm, throat inspection, lung auscultation, liver and spleen palpation, and kidney percussion;

[0111] (iii) Laboratory examinations: routine blood test, routine urine test, electrocardiogram, liver and kidney function tests.

[0112] ② Observation of therapeutic efficacy

[0113] The main clinical symptoms and signs of withdrawal syndrome and the severity classification standards:

[0114] 1. Chills

[0115] (+): Mild, with trembling fingers and cold limbs;

[0116] (++): obvious, tremors in the limbs and lips, chills all over the body, relieved by covering with clothes and quilts;

[0117] (+++): Severe, with tremors in the head, face, limbs and trunk, and whole body shivering, which is difficult to relieve even with clothes or quilts.

[0118] (ii) Fever

[0119] (+): Mild, body temperature below 37.6-38.0℃;

[0120] (++): obvious, body temperature 38.1~39.0℃;

[0121] (+++): Severe, body temperature is above 39.1℃.

[0122] (III) Sneezing

[0123] (+): intermittent, low-pitched sound;

[0124] (++): more, deeper sound;

[0125] (+++): Frequent, with discharge of nasal discharge and other secretions.

[0126] (IV) Headache and body pain

[0127] (+): Headache, body aches, or mild pain;

[0128] (++): Headache, obvious soreness or pain in the limbs, but can continue to work or engage in normal activities;

[0129] (+++): Severe headache and / or pain in the body or limbs, which makes it difficult to work or carry out normal activities.

[0130] (V) Runny nose

[0131] (+) Slightly runny nose;

[0132] (++): Occasional clear or turbid discharge of mucus, with a large amount;

[0133] (+++): Frequent clear or heavy nasal discharge.

[0134] (VI) Tears

[0135] (+): slight tearing, small amount;

[0136] (++): obvious tearing and large amount;

[0137] (+++): Constant tears, heavy.

[0138] 7. Yawning

[0139] (+): Occasional yawning, less than 4 times per hour;

[0140] (++): Frequent yawning, less than 5 to 8 times per hour;

[0141] (+++): Frequent yawning, more than 10 times per hour.

[0142] (8) Goose Bumps

[0143] (+): Mild, sparse, no obvious change in skin color;

[0144] (++): Moderate, dense, with changes in skin color;

[0145] (+++): Severe, with dense pimples, pale skin, and skin that feels rough to the touch.

[0146] (IX) Excessive sweating

[0147] (+): only slight perspiration in some parts of the body;

[0148] (++): Sweating all over the body, clothes soaked with sweat;

[0149] (+++): Sweating profusely, clothes often soaked with sweat, and clothes must be changed frequently.

[0150] (10) Nausea and vomiting

[0151] (+): Nausea several times a day, but no vomiting;

[0152] (++): Frequent nausea, more than 6 times a day, or vomiting 1 to 2 times a day;

[0153] (+++): Vomiting more than 3 times a day.

[0154] (11) Abdominal pain

[0155] (+): dull pain, short-lived;

[0156] (++): The abdominal pain is severe but tolerable, or the pain lasts for a long time (more than 4 hours a day);

[0157] (+++): Severe abdominal pain, recurrent pain, or moderate pain that lasts for a long time (more than 8 hours a day).

[0158] (XII) Diarrhea

[0159] (+): 3 to 5 bowel movements per day, with changes in stool characteristics and volume;

[0160] (++): 6 to 8 or more bowel movements per day, with changes in stool characteristics and volume;

[0161] (+++): 9 or more bowel movements per day, with changes in stool character and quantity.

[0162] (13) Irritability

[0163] (+): Mood swings or occasional irritability;

[0164] (++): Often angry, but still able to control oneself;

[0165] (+++): Anger is difficult to control and requires medication.

[0166] (XIV) Insomnia (+): often awakening during sleep or restless sleep, waking up too early in the morning, but not affecting work; (++): less than 4 hours of sleep, but still able to work;

[0167] (+++): Sleepless nights and difficulty maintaining normal work.

[0168] (XV) Dryness and heat (+): Mild dryness and heat in the head, face, chest and heart;

[0169] (++): Moderate, with general heatiness, but still tolerable;

[0170] (+++): Severe, with discomfort and dryness all over the body, making it difficult to sit or lie still, and unbearable.

[0171] (XVI) Fatigue (+): Fatigue and fatigue, but no significant impact on work and study;

[0172] (++): Fatigue and laziness, which has a certain impact on work and study;

[0173] (+++): Fatigue and fatigue, obvious symptoms, and a significant decline in work and study efficiency.

[0174] (XVII) Excessive sputum (+): expectoration or spitting of 10-50 ml day and night;

[0175] (++): expectoration or spitting 51-100 ml day and night;

[0176] (+++): Coughing up or spitting out more than 100 ml of sputum during the day and night.

[0177] (18) Melancholy (+): Occasionally feel depressed;

[0178] (++): Melancholy, silent;

[0179] (+++): Feeling depressed and silent all day long.

[0180] (19) Anxiety (+): Occasionally anxious;

[0181] (++): Anxiety sometimes occurs, which may be accompanied by tension and irritability;

[0182] (+++): Feeling anxious all day, often accompanied by tension, irritability or fear.

[0183] 20. Hallucination (or Illusion)

[0184] (+): Once a day or every few days, for a short period of time;

[0185] (++): 2 to 3 times a day;

[0186] (+++): More than 4 times a day, or more than once a day but for a longer duration.

[0187] (21) Dilated pupils

[0188] (+): pupil diameter 4.6-4.9 mm;

[0189] (++): pupil diameter 5.0-5.4 mm;

[0190] (+++): Pupil diameter is greater than 5.5 mm.

[0191] (22) Delusion

[0192] (+): Mild, usually without obvious behavioral abnormalities;

[0193] (++): Severe, often with delusions of victimization, grandiosity, jealousy, etc., and may also have abnormal behaviors such as seeking protection and stalking;

[0194] (+++): Severe, with multiple delusions occurring simultaneously, often accompanied by more serious manic behavior, and even destruction of property and injury to others.

[0195] (23) Lack of concentration

[0196] (+): Mild, no significant impact on study and work;

[0197] (++): Moderate weakening of active attention function, and decreased learning and work efficiency;

[0198] (+++): The active attention function is significantly weakened, and it is easy to be attracted by irrelevant stimuli, and the learning and work efficiency is seriously reduced.

[0199] (24) Craving (Addiction)

[0200] (+): Mild craving for the drug, which may be accompanied by physical dependence symptoms, but the degree is relatively mild;

[0201] (++): The craving for the drug is between (+) and (+++), and there may be more obvious symptoms of physical dependence;

[0202] (+++): Intense and unbearable craving for the drug, often accompanied by severe withdrawal symptoms, and even psychological and behavioral abnormalities such as aggression, self-injury, and self-mutilation.

[0203] Judgment criteria: If there is no above symptom, 0 points will be scored; (+), (++), (+++) will be scored 1, 2, and 3 points respectively.

[0204] (4) Observation method

[0205] First, the test cases that meet the criteria are numbered according to the order of visit, and the cases are randomly assigned to the treatment group and the control group according to the random number table. A comprehensive physical examination and relevant laboratory examinations are conducted on the drug addicts. After three days, the patients in the treatment group are asked to smoke, with a total smoking time of 10 to 13 hours per day, 15 to 30 minutes per time, and an interval of more than 15 minutes. The difference between the control group 1 and the treatment group is that the mouthpiece is not filled with the mouthpiece filter element composition, and the drug addiction and detoxification Chinese medicine combination preparation only includes the drug addiction and detoxification Chinese medicine composition. The control group 2 smokes ordinary electronic cigarettes. Try to smoke under the care of the staff for 4 consecutive days. After the 4th day, the treatment group is controlled to a total smoking time of 6 to 9 hours per day, 15 to 25 minutes per time, and an interval of more than 30 minutes. Smoke for another 5 days, a total of 9 days, and other drug addiction products should be stopped during these 9 days. After the observation, conduct another comprehensive physical examination and review the relevant physical and chemical experimental items.

[0206] (5) Summary method

[0207] With reference to the "Guidelines for Clinical Research of New Chinese Medicines" formulated by the Ministry of Health (1993-1997), the "Handbook of Drug Control and Detoxification" (heroin), the "Clinical Diagnosis and Treatment of Heroin Addiction", the "New Guide to Drug Detoxification" and other documents, and combined with actual clinical conditions, the following efficacy standards were formulated.

[0208] Reduction rate = (score before treatment - score after treatment) / score before treatment × 100%

[0209] Clinical control standard: Clinical symptoms are basically controlled, with a reduction rate of 90-100%.

[0210] Significantly effective criteria: clinical symptoms improved significantly, with a reduction rate of 60-89%.

[0211] Effectiveness standard: Clinical symptoms improved, with a score reduction rate of 30-60%.

[0212] Invalid criteria: No change or insignificant change in clinical symptoms, and the score reduction rate is below 30%.

[0213] (6) Observation results

[0214] Table 1 Results of the treatment group test in a drug rehabilitation center in Maoming City, Guangdong Province

[0215]

[0216]

[0217] Table 1 continued

[0218]

[0219]

[0220]

[0221] Table 2 Results of the treatment group test in a drug rehabilitation center in Maoming City, Guangdong Province

[0222]

[0223]

[0224] Table 2

[0225]

[0226]

[0227] Table 3 Results of the treatment group test in a drug rehabilitation center in Huaihua City, Hunan Province

[0228]

[0229]

[0230]

[0231] Table 3

[0232]

[0233]

[0234] Table 4 Results of the treatment group test in a drug rehabilitation center in Jiangmen City, Guangdong Province

[0235]

[0236]

[0237] Table 4

[0238]

[0239]

[0240] From the results of Tables 1 to 4, it can be seen that the total effective rate of the treatment group is significantly different from that of the control group 2, indicating that the inhaled Chinese medicine combination preparation for drug addiction treatment of the present invention can play an effective role in the drug addiction treatment stage. Based on the comparison of the results of the treatment group and the control group 1, it can be seen that the use of the Chinese medicine composition for drug addiction treatment and the mouthpiece filter element composition together can prevent the high-temperature active volatiles from affecting the patient's alveoli and affecting the efficacy of the drug.

[0241] 25, 38, 45, and 40 people were randomly selected from the treatment groups of drug-free personnel in a drug rehabilitation center in Maoming City, Guangdong Province, a drug rehabilitation center in Chenzhou City, Hunan Province, a drug rehabilitation center in Huaihua City, Hunan Province, and a drug rehabilitation center in Jiangmen City, Guangdong Province after the aforementioned treatment. After returning home, they continued to use the product of the present invention, with a total suction time of 1 to 3 hours per day, each time for 15 to 25 minutes, and an interval of not less than 1.5 hours. Regularly visit their situation after returning home and record the main clinical symptoms and signs of withdrawal syndrome, and calculate the current main symptom score average of each drug rehabilitation center, and the results are shown in Table 5.

[0242] Table 5 Detoxification status of each drug rehabilitation center

[0243]

[0244] From the results in Table 5, it can be seen that the average value of the main symptom score of the patients who continued to use the inhalation-type drug addiction treatment and detoxification Chinese medicine combination preparation of the present invention after drug rehabilitation gradually decreased, and the value was lower than 1.0 after two years, indicating that the inhalation-type drug addiction treatment and detoxification Chinese medicine combination preparation of the present invention not only has the function of early drug rehabilitation, but also can play a role in late addiction treatment to prevent relapse.

[0245] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention is described in detail with reference to the preferred embodiments, it is not limited to those listed in the embodiments. Those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. An inhalable Chinese medicine combination preparation for drug addiction treatment, characterized in that: A heated drug administration device is used for suction, comprising a drug addiction treatment Chinese medicine composition and a nozzle filter element composition. Calculated by weight, the raw materials of the drug addiction treatment Chinese medicine composition include 3 to 14 parts of astragalus, 2 to 9 parts of spinach seed, 1 to 9 parts of schisandra chinensis, 15 to 35 parts of corydalis, 2 to 8 parts of liquorice, 1 to 6 parts of ginseng and 2 to 8 parts of atractylodes; the raw materials of the nozzle filter element composition include 4 to 13 parts of gypsum, 3 to 9 parts of artemisia annua, 5 to 14 parts of corn silk and 18 to 26 parts of plant charcoal.

2. The inhalation-type drug addiction treatment Chinese medicine combination formulation according to claim 1, characterized in that: The raw materials of the Chinese medicine composition for drug addiction treatment include 4-12 parts of astragalus, 4-7 parts of spinach seed, 3-7 parts of schisandra chinensis, 18-30 parts of corydalis, 3-8 parts of liquorice, 2-6 parts of ginseng and 2-6 parts of atractylodes.

3. The inhalation-type drug addiction treatment Chinese medicine combination formulation according to claim 2, characterized in that: The raw materials of the Chinese medicine composition for drug addiction treatment include 4-8 parts of astragalus, 5-6 parts of spinach seeds, 4-6 parts of schisandra chinensis, 20-27 parts of corydalis, 3-6 parts of liquorice, 2-5 parts of ginseng and 3-5 parts of atractylodes.

4. The inhalation-type drug addiction treatment Chinese medicine combination formulation according to claim 3, characterized in that: The raw materials of the Chinese medicine composition for drug addiction treatment include 5-7 parts of astragalus, 6 parts of spinach seeds, 5 parts of schisandra chinensis, 20-23 parts of corydalis, 5 parts of liquorice, 2-4 parts of ginseng and 4 parts of atractylodes.

5. The inhalation-type drug addiction treatment Chinese medicine combination formulation according to claim 1, characterized in that: The suction nozzle filter element composition comprises 4 to 10 parts of gypsum, 3 to 7 parts of sweet wormwood, 8 to 14 parts of corn silk and 20 to 26 parts of plant charcoal.

6. The inhalation-type Chinese medicine combination preparation for drug addiction treatment according to claim 5, characterized in that: The suction nozzle filter element composition comprises 6 to 9 parts of gypsum, 3 to 5 parts of sweet wormwood, 8 to 12 parts of corn silk and 20 to 23 parts of plant charcoal.

7. The inhalation-type Chinese medicine combination preparation for drug addiction treatment according to claim 6, characterized in that: The suction nozzle filter element composition comprises 7 to 8 parts of gypsum, 4 parts of sweet wormwood, 8 to 10 parts of corn silk and 22 parts of plant charcoal.

8. The method for preparing the inhalable Chinese medicine combination preparation for drug addiction treatment according to claims 1 to 7, characterized in that: Includes steps: (1) Preparation of Chinese medicine composition for drug addiction treatment The spiny jujube seeds, the schisandra chinensis, the corydalis yanhusuo and part of the liquorice are mixed, soaked and boiled, and the filtrate is filtered to be concentrated to a paste to obtain an extract, the astragalus, the ginseng, the atractylodes macrocephala and the remaining liquorice are washed, dried and crushed, and the crushed material is mixed with the extract, pressed and sliced ​​into medicinal threads; (2) Nozzle filter composition The artemisia annua is washed, dried and chopped; the corn silk is cut into sections, dried and crushed; the raw gypsum, the plant charcoal, the processed artemisia annua and the processed corn silk are sieved, fully mixed and sterilized; white wine is added to mix to obtain a semi-loose mixture; the mixture is dried to semi-dry for granulation and dried to obtain a filter element.

9. A drug delivery device, characterized in that: It comprises a shell body provided with a bearing cavity, a heating device and a suction nozzle piece connected to the bearing cavity, one end of the suction nozzle piece is connected to the bearing cavity, and the other end of the suction nozzle piece is exposed from the shell body, the bearing cavity carries the drug-detoxification and detoxification Chinese medicine combination preparation described in claims 1 to 7, the heating device is used to heat the drug-detoxification and detoxification Chinese medicine composition in the bearing cavity to produce active volatiles, and the suction nozzle piece is filled with the suction nozzle filter element composition described in claims 1 to 7.

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