Buccal product and preparation method thereof

Abstract

The invention discloses a buccal product and a preparation method thereof, and belongs to the technical field of smokeless tobacco products. The buccal product comprises a composition, and the composition comprises the following components in parts by mass: 1-10 parts of a nicotine active component, 20-40 parts of a medicinal component, 30-70 parts of a slow-release component, 0.5-10 parts of an adhesive, 0.1-10 parts of a flavoring agent, 0.1-5 parts of a sweetening agent and 0.1-5 parts of an acid-base regulator, wherein the medicinal components comprise extracts of Chinese herbal medicines for preventing phlegm from forming and stopping coughing. According to the buccal product provided by the invention, the release speed of the nicotine active component can be adjusted based on the selection of the raw material components and the proportional relation among the raw material components, and the medicinal components can achieve the effects of preventing phlegm from forming and stopping coughing and cannot bring satisfaction due to covering of the nicotine active component; and the extract can be quickly released along with the nicotine active component, so that the irritation of the nicotine active component to the oral cavity is reduced, and cough and expectoration are relieved.

Description

Technical Field

[0001] The present application relates to the technical field of smokeless tobacco products, and in particular to an oral product and a preparation method thereof. Background Art

[0002] Oral products are smokeless products containing nicotine. Oral products usually do not need to be burned. Instead, they are placed in the mouth so that nicotine is absorbed by the oral mucosa, providing consumers with a certain nicotine satisfaction through oral administration. However, the strong alkalinity of nicotine may irritate the user's oral mucosa, easily causing coughing and sputum, affecting the user experience. Summary of the invention

[0003] The present application provides an oral product and a preparation method thereof, which can solve the technical problem that nicotine in the oral product easily induces coughing and sputum.

[0004] In order to solve the above technical problems, the present application provides an oral product on the one hand, which includes a composition, which includes, by weight: 1-10 parts of nicotine active ingredient, 20-40 parts of medicinal ingredients, 30-70 parts of sustained-release ingredients, 0.5-10 parts of adhesives, 0.1-10 parts of flavoring agents, 0.1-5 parts of sweeteners, and 0.1-5 parts of acid-base regulators; wherein the medicinal ingredients include extracts of expectorant and cough-relieving Chinese herbal medicines.

[0005] In one embodiment, the expectorant and cough relieving Chinese herbal medicine includes at least one of Platycodon grandiflorum, Fritillaria cirrhosa, Fritillaria thunbergii, Rhizoma Anemarrhenae, Seaweed, Coltsfoot Flos and Loquat Leaf.

[0006] In one embodiment, the sustained-release component includes at least one of microcrystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, sodium hydroxymethylcellulose, polyvinyl pyrrolidone, sodium alginate, methylcellulose, hydroxyethyl cellulose, cellulose acetate phthalate, xylitol, mannitol, sorbitol, xylitol, erythritol, maltitol, lactitol, starch and sucrose; and / or, the nicotine active ingredient includes at least one of nicotine salt, sodium nicotinate, potassium nicotinate, nicotine and hexamethyl nicotine; and / or, the binder includes povidone , hydroxypropyl methylcellulose, sodium carboxymethyl cellulose and hydroxypropyl cellulose; and / or, the sweetener includes at least one of stevia, xylitol, ignol, aspartame, mannitol, sorbitol, erythritol, maltitol, lactitol, saccharin sodium, mongoose, sukram, agave sugar, maple syrup, fructose, neotame, alitame, aspartame, cyclamate, acesulfame potassium, steviol glycosides, monk fruit sweeten and adventitone; and / or, the acid-base regulator includes at least one of sodium carbonate, sodium bicarbonate, citric acid and lactic acid.

[0007] In one embodiment, the moisture content of the oral product is less than or equal to 7%; or, the moisture content of the oral product is 10%-30%.

[0008] On the other hand, the present application provides a method for preparing an oral product, which comprises: processing expectorant and cough relieving Chinese herbal medicine to obtain an extract; mixing the raw materials with a solvent to obtain a mixed solution, wherein the raw materials comprise, by weight, 1-10 parts of nicotine active ingredient, 20-40 parts of extract, 20-50 parts of sustained-release component, 0.5-10 parts of adhesive, 0.1-10 parts of flavoring agent, 0.1-5 parts of sweetener, and 0.1-5 parts of acid-base regulator; and treating the mixed solution by spray drying to obtain the oral product.

[0009] In one embodiment, the step of processing the expectorant and cough relieving Chinese herbal medicine to obtain the extract comprises: extracting the expectorant and cough relieving Chinese herbal medicine using a supercritical fluid extraction process.

[0010] In one embodiment, the entrainer in the supercritical fluid extraction process is 50%-90% ethanol, the extraction pressure is 20MPa-40MPa, the temperature is 40°C-50°C, and the extraction time is 0.5h-2h.

[0011] In one embodiment, the gas flow rate for treating the mixed liquid by spray drying is 20m3 / h-40m3 / h, the spray rate is 5mL / min-10mL / min, the heating temperature is 50℃-60℃, and the atomization pressure is 0.01MPa-0.05MPa.

[0012] In one embodiment, the mixed liquid is treated by spray drying to obtain an oral product, including: spray drying the mixed liquid to obtain solid particles, controlling the water content of the solid particles to be 10%-30%, and bagging to obtain the oral product; or, spray drying the mixed liquid to obtain solid particles, vacuum drying the solid particles, controlling the water content of the solid particles to be less than or equal to 7%, and bagging to obtain the oral product.

[0013] The oral preparation provided by the present application is based on the selection of raw material components and the ratio relationship between the raw material components. The medicinal ingredients include extracts of expectorant and cough-relieving Chinese herbal medicines, so that the ratio between the nicotine active ingredient, the medicinal ingredients and the sustained-release ingredient is appropriate. The sustained-release ingredient can form an effective carrier of the nicotine active ingredient and can adjust the release rate of the nicotine active ingredient. The medicinal ingredients can have the effect of expectorating and relieving cough without covering up the satisfaction brought by the nicotine active ingredient. Moreover, compared with powdered Chinese herbal medicines, the release rate of the extract is faster, and the extract can be quickly released along with the nicotine active ingredient, so that the active ingredients of the expectorant and cough-relieving Chinese herbal medicines can quickly act on the oral cavity, reduce the irritation of the nicotine active ingredient to the oral cavity, and thus relieve cough and sputum. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0015] Figure 1 It is a schematic diagram of a process of an embodiment of a method for preparing an oral product provided by the present application;

[0016] Figure 2 is the dissolution curve diagram of Example A;

[0017] Figure 3 is the dissolution curve diagram of Example B;

[0018] Figure 4 is the dissolution curve diagram of Example C;

[0019] Figure 5 is the dissolution curve diagram of Example D;

[0020] Figure 6 It is a comparative diagram of the dissolution curves of Examples AD. DETAILED DESCRIPTION

[0021] The present application is further described in detail below in conjunction with the accompanying drawings and examples. It is particularly noted that the following examples are only used to illustrate the present application, but are not intended to limit the scope of the present application. Similarly, the following examples are only some embodiments of the present application rather than all embodiments, and all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present application.

[0022] In the description of the present application, the meaning of "multiple" is at least two, such as two, three, etc., unless otherwise clearly and specifically limited. The terms "first", "second", and "third" in the embodiments of the present application are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first", "second", and "third" can expressly or implicitly include at least one of the features. In the embodiments of the present application, all directional indications (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication also changes accordingly. The terms "including" and "having" in the embodiments of the present application and any of their variations are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but optionally also includes steps or units that are not listed, or optionally also includes other steps or components inherent to these processes, methods, products, or devices.

[0023] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0024] The present application provides an oral product. The oral product includes a composition, which includes, by weight, 1-10 parts of nicotine active ingredients, 20-40 parts of medicinal ingredients, 30-70 parts of sustained-release ingredients, 0.5-10 parts of adhesives, 0.1-10 parts of flavoring agents, 0.1-5 parts of sweeteners, and 0.1-5 parts of acid-base regulators. The nicotine active ingredient includes nicotine or nicotine derivatives, which are used to provide nicotine or substances with similar effects to nicotine. When the oral product is placed in the oral cavity, the nicotine active ingredient is released into the oral cavity, thereby providing consumers with a certain nicotine satisfaction. The sustained-release ingredient can be used as a carrier of the nicotine active ingredient, thereby adjusting the release rate of the nicotine active ingredient. The adhesive stabilizes the structure of the oral product and is used to improve the taste consistency of the oral product. The flavoring agent is used to adjust the taste, and the sweetener can increase the diversity of the taste of the oral product. The acid-base regulator is used to adjust the pH value of the oral product to optimize the stability and release efficiency of the nicotine active ingredient.

[0025] The medicinal ingredients include extracts of expectorant and cough-relieving Chinese herbal medicines. Expectorant and cough-relieving Chinese herbal medicines have the effect of expectorant and cough-relieving. Compared with powdered Chinese herbal medicines, the release speed of the extracts is faster, and the extracts can be quickly released with the nicotine active ingredient, so that the effective ingredients of the expectorant and cough-relieving Chinese herbal medicines can quickly act on the oral cavity, reduce the irritation of the nicotine active ingredient to the oral cavity, and thus relieve cough and sputum. By controlling 1-10 parts of nicotine active ingredients, 20-40 parts of medicinal ingredients, and 30-70 parts of sustained-release ingredients, the ratio between nicotine active ingredients, medicinal ingredients, and sustained-release ingredients is appropriate. On the one hand, the sustained-release ingredient can form an effective carrier of the nicotine active ingredient and can adjust the release speed of the nicotine active ingredient; on the other hand, it will not have the effect of expectorant and cough-relieving due to too few medicinal ingredients, nor will it cover up the satisfaction brought by the nicotine active ingredient due to too many medicinal ingredients. In some embodiments, the mass fraction of nicotine active ingredient can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts; the mass fraction of medicinal ingredients can be 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 parts, 35 parts, 38 parts or 40 parts; the mass fraction of sustained-release components can be 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts or 70 parts, which are not specifically limited here.

[0026] The oral preparation provided by the present application is based on the selection of raw material components and the ratio relationship between the raw material components. The medicinal ingredients include extracts of expectorant and cough-relieving Chinese herbal medicines, so that the ratio between the nicotine active ingredient, the medicinal ingredients and the sustained-release ingredient is appropriate. The sustained-release ingredient can form an effective carrier of the nicotine active ingredient and can adjust the release rate of the nicotine active ingredient. The medicinal ingredients can have the effect of expectorating and relieving cough without covering up the satisfaction brought by the nicotine active ingredient. Moreover, compared with powdered Chinese herbal medicines, the release rate of the extract is faster, and the extract can be quickly released along with the nicotine active ingredient, so that the active ingredients of the expectorant and cough-relieving Chinese herbal medicines can quickly act on the oral cavity, reduce the irritation of the nicotine active ingredient to the oral cavity, and thus relieve cough and sputum.

[0027] In one embodiment, the expectorant and cough relieving Chinese herbal medicine comprises at least one of Platycodon grandiflorum, Fritillaria cirrhosa, Fritillaria thunbergii, Rhizoma Anemarrhenae, Seaweed, Coltsfoot Flower and Loquat Leaf. The above medicinal materials have the efficacy of expectorant and cough relieving, and can reduce the irritation of the active ingredient of nicotine to the oral cavity.

[0028] In one embodiment, the sustained-release component includes at least one of microcrystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, sodium hydroxymethylcellulose, polyvinyl pyrrolidone, sodium alginate, methylcellulose, hydroxyethyl cellulose, cellulose acetate phthalate, xylitol, mannitol, sorbitol, xylitol, erythritol, maltitol, lactitol, starch and sucrose.

[0029] In one embodiment, the nicotine active ingredient includes at least one of nicotine salt, sodium nicotinate, potassium nicotinate, nicotine and hexamethyl nicotine. The nicotine active ingredient may also include other nicotine derivatives, which are not described in detail in this application. Nicotine salts include nicotine tartrate, nicotine benzoate, nicotine lactate, nicotine valerate, nicotine salicylate, and the like.

[0030] In one embodiment, the binder includes at least one of povidone, hydroxypropyl methylcellulose and sodium carboxymethylcellulose.

[0031] In one embodiment, the flavoring agent includes flavors, such as edible flavors such as mint flavor, chrysanthemum flavor, fruit flavor, coffee flavor, and tobacco flavor.

[0032] In one embodiment, the sweetener includes at least one of stevia, xylitol, ignitol, aspartame, mannitol, sorbitol, erythritol, maltitol, lactitol, saccharin sodium, mongoose, sukram, agave sugar, maple syrup, fructose, neotame, alitame, aspartame, cyclamate, acesulfame potassium, steviol glycosides, monk fruit sweeten and adventitone.

[0033] In one embodiment, the acid-base adjuster includes at least one of sodium bicarbonate, sodium carbonate, citric acid and lactic acid.

[0034] In one embodiment, the oral product further comprises a solvent, and the oral product comprises 10-20 parts by weight of the solvent, wherein the solvent comprises at least one of water, ethanol, propylene glycol and glycerol.

[0035] The time when the nicotine active ingredient in the oral product is released by 80% is taken as the peak time. The moisture content of the oral product will affect the peak time. In one embodiment, the moisture content of the oral product is less than or equal to 7%. In one embodiment, the oral product can be obtained by dry processing, so that the moisture content of the oral product is relatively small, and the peak time of the obtained oral product can be 5min-20min.

[0036] In one embodiment, the moisture content of the oral product is 10%-30%. In one embodiment, the oral product can be obtained by wet processing, so that the moisture content of the oral product is relatively large, and the peak time of the prepared oral product can be 20min-35min. By controlling the moisture content of the oral product, the nicotine active ingredient release rate of the product can be in line with expectations, and the peak time of the prepared products is different, which can meet the personalized needs of users.

[0037] The present application provides a method for preparing an oral product. Figure 1 The preparation method may include steps S10-S30:

[0038] S10, processing the expectorant and cough relieving Chinese herbal medicine to obtain an extract. Compared with the powdered Chinese herbal medicine, the extract has a faster release speed, and the extract can be quickly released along with the nicotine active ingredient, so that the effective ingredients of the expectorant and cough relieving Chinese herbal medicine can quickly act on the oral cavity, reducing the irritation of the nicotine active ingredient to the oral cavity, thereby relieving cough and expectoration.

[0039] S20, mixing the raw materials with the solvent to obtain a mixed solution, wherein the raw materials include, by weight, 1-10 parts of nicotine active ingredients, 20-40 parts of extracts, 20-50 parts of sustained-release ingredients, 0.5-10 parts of adhesives, 0.1-10 parts of flavoring agents, 0.1-5 parts of sweeteners, and 0.1-5 parts of acid-base regulators. Based on the selection of raw material components and the proportional relationship between the raw material components, the ratio between the nicotine active ingredient, the medicinal ingredient, and the sustained-release ingredient is appropriate. On the one hand, the sustained-release ingredient can form an effective carrier of the nicotine active ingredient and can adjust the release rate of the nicotine active ingredient; on the other hand, it will not have the effect of expectoration and cough relief due to too little medicinal ingredients, nor will it cover up the satisfaction brought by the nicotine active ingredient due to too much medicinal ingredients.

[0040] S30, treating the mixed solution by spray drying to obtain an oral product. The mixed solution is spray dried so that the nicotine active ingredient is attached to the sustained-release component, and the adhesive bonds the raw materials together to form a stable structure, which is conducive to the stable and sustained release of the nicotine active ingredient and improves the taste consistency of the oral product.

[0041] The reflux extraction method can be used to extract the active ingredients from the expectorant and cough relieving Chinese herbal medicines. The reflux extraction method uses volatile organic solvents such as ethanol to extract the ingredients from the raw materials. This method heats the extract and distills it, allowing the solvent to evaporate, cool it, and then reflux it into the extraction container. This process is repeated until the active ingredients are completely extracted.

[0042] In one embodiment, the process of processing the expectorant and cough-relieving Chinese herbal medicine to obtain an extract includes: extracting the expectorant and cough-relieving Chinese herbal medicine using a supercritical fluid extraction process. Supercritical fluid extraction uses a supercritical fluid, i.e., a fluid in a thermodynamic state with a temperature higher than a critical temperature and a pressure higher than a critical pressure, as an extractant to extract effective ingredients from the expectorant and cough-relieving Chinese herbal medicine. Since supercritical fluid extraction is operated at a relatively low temperature, it is possible to prevent the effective ingredients in the Chinese herbal medicine from being destroyed during the extraction process, thereby ensuring the expectorant and cough-relieving efficacy of the medicinal ingredients.

[0043] In one embodiment, the entrainer in the supercritical fluid extraction process is 50%-90% ethanol, the extraction pressure is 20MPa-40MPa, the temperature is 40℃-50℃, and the extraction time is 0.5h-2h. Using ethanol as an entrainer can improve the solubility of the active ingredients in Chinese herbal medicines, and controlling the extraction pressure to 20MPa-40MPa can improve the efficiency of the extraction process, thereby reducing production costs. Controlling the extraction temperature at 40℃-50℃ can prevent the active ingredients in the Chinese herbal medicines from being destroyed by excessively high temperatures during the extraction process, thereby ensuring the expectorant and cough-relieving effects of the medicinal ingredients.

[0044] In one embodiment, the gas flow rate of the spray drying mixed liquid is 20m 3 / h-40m 3 / h, the spray rate is 5mL / min-10mL / min, the heating temperature is 50℃-60℃, and the atomization pressure is 0.01MPa-0.05MPa. By controlling the process parameters of the spray drying method, the sustained-release component can be made into an effective carrier of the nicotine active ingredient, and the adhesive can bond the raw materials together to form a stable structure, thereby preparing a loose and porous oral product, which is conducive to adjusting the release rate of the nicotine active ingredient.

[0045] In one embodiment, a dry process is used to prepare an oral product, and the mixed liquid is treated by spray drying to obtain the oral product, including: spray drying the mixed liquid to obtain solid particles, the water content of the solid particles is controlled to be 10%-30%, and the oral product is bagged. The nicotine active ingredient in the oral product prepared by the dry process is released faster, and a quick-release product can be prepared.

[0046] In one embodiment, the oral product is prepared by a wet process, and the mixed solution is treated by a spray drying method to obtain the oral product, including: spray drying the mixed solution to obtain solid particles, vacuum drying the solid particles, controlling the water content of the solid particles to be less than or equal to 7%, and bagging to obtain the oral product. The nicotine active ingredient in the oral product prepared by the wet process is released slowly, and a slow-release product can be prepared.

[0047] The present application is described below through specific examples, in which oral products are prepared according to the above preparation method. The following examples are only partial examples of the present application and are not intended to limit the present application.

[0048] Example A, the formula is shown in Table 1.

[0049] Table 1 Example A formula table (dry method)

[0050]

[0051]

[0052] Example B, the formula is shown in Table 2.

[0053] Table 2 Example B formulation (dry method)

[0054]

[0055] Example C, the formula is shown in Table 3.

[0056] Table 3 Example C formula table (wet method)

[0057]

[0058]

[0059] Example D, the formula is shown in Table 4.

[0060] Table 4 Example D formula table (wet method)

[0061] Components Element Mass content (%) Sustained release ingredients Erythritol 35 Nicotine active ingredient Nicotine tartrate 3 Medicinal ingredients Loquat Leaf Extract 35 Adhesives Povidone 3 Flavoring Watermelon flavor 4 Sweeteners Neotame 0.5 Acid-base regulator Sodium carbonate 0.5 Solvents water 19

[0062] The oral preparation prepared in the example was subjected to a dissolution test.

[0063] Equipment: Dissolution apparatus-paddle method;

[0064] Sample: 1 g of each of the powders of different formulas of Examples A, B, C, and D;

[0065] Dissolution medium: artificial saliva-pH 6.8;

[0066] Sampling points: 0.5min, 1min, 2min, 5min, 10min, 15min, 30min, 45min, 60min;

[0067] Test conditions: heating temperature 37°C, speed 100r / min;

[0068] Analysis method: Nicotine content was determined using high performance liquid chromatography.

[0069] The test results are shown in Table 5 and Figure 2-Figure 6 shown.

[0070] Table 5 Example test results

[0071] Time(min) A(mg) B(mg) C(mg) D(mg) 0.5 0.56 1.56 2.21 0.78 1 7.9 2.1 3.95 1.63 2 15.4 3.24 12.76 3.18 5 21.65 6.56 18.45 12.73 10 27.39 11.5 25.73 17.42 15 36.28 16.56 32.75 22.12 30 39.23 19.43 39.55 26.36 45 39.35 19.68 47.37 28.23 60 39.42 19.95 49.92 29.59

[0072] from Figure 2-Figure 6It can be seen that the dissolution curves of Examples AD are relatively smooth. The test results show that based on the selection of raw material components and the proportional relationship between the raw material components, the ratio between the nicotine active ingredient, the medicinal ingredient and the sustained-release ingredient is appropriate, and the sustained-release ingredient forms an effective carrier of the nicotine active ingredient, which can adjust the release rate of the nicotine active ingredient, so that the nicotine active ingredient is released stably and continuously; and the extract can be quickly released with the nicotine active ingredient, so that the effective ingredients of the expectorant and cough-relieving Chinese herbal medicine can quickly act on the oral cavity, reduce the irritation of the nicotine active ingredient to the oral cavity, and thus relieve cough and expectoration.

[0073] In addition, from Figure 2-Figure 6 It can be seen that in Examples AD, the time when 80% of the nicotine active ingredient in the oral product is released is taken as the peak time, the peak time of the oral product obtained by dry processing is 5min-20min (Examples A and B), and the peak time of the oral product obtained by wet processing is 20min-35min (Examples C and D). The products prepared by different granulation processes have different peak times, which can meet the personalized needs of users.

[0074] The above descriptions are only some embodiments of the present application, and do not limit the protection scope of the present application. Any equivalent device or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly used in other related technical fields, are also included in the patent protection scope of the present application.

Claims

1. An oral product, characterized in that: The invention comprises a composition, wherein the composition comprises, by weight: 1-10 parts of nicotine active ingredient, 20-40 parts of medicinal ingredients, 30-70 parts of sustained-release ingredients, 0.5-10 parts of adhesives, 0.1-10 parts of flavoring agents, 0.1-5 parts of sweeteners, and 0.1-5 parts of acid-base regulators; Wherein, the medicinal ingredients include extracts of expectorant and cough-relieving Chinese herbal medicines.

2. The oral product according to claim 1, characterized in that The expectorant and cough relieving Chinese herbal medicine comprises at least one of Platycodon grandiflorum, Fritillaria cirrhosa, Fritillaria thunbergii, Rhizoma Anemarrhenae, Seaweed, Coltsfoot flower and Loquat leaf.

3. The oral product according to claim 1, characterized in that The sustained-release component includes at least one of microcrystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, sodium hydroxymethyl cellulose, polyvinyl pyrrolidone, sodium alginate, methylcellulose, hydroxyethyl cellulose, cellulose acetate phthalate, xylitol, mannitol, sorbitol, xylitol, erythritol, maltitol, lactitol, starch and sucrose; and / or, The nicotine active ingredient includes at least one of nicotine salt, sodium nicotinate, potassium nicotinate, nicotine and hexamethyl nicotine; and / or, The binder comprises at least one of povidone, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose and hydroxypropyl cellulose; and / or, The sweetener comprises at least one of stevioside, xylitol, ignol, aspartame, mannitol, sorbitol, erythritol, maltitol, lactitol, saccharin sodium, mongoose, sukram, agave sugar, maple syrup, fructose, neotame, alitame, aspartame, cyclamate, acesulfame potassium, steviol glycoside, monk fruit sweeten and adventitone; and / or, The acid-base regulator includes at least one of sodium carbonate, sodium bicarbonate, citric acid and lactic acid.

4. The oral product according to claim 1, characterized in that The moisture content of the oral product is less than or equal to 7%; or, the moisture content of the oral product is 10% to 30%.

5. The oral product according to any one of claims 1 to 4, characterized in that: The buccal article further comprises a osmotic bag, wherein the osmotic bag is used to package the composition.

6. A method for preparing an oral product, characterized in that: include: The expectorant and cough relieving Chinese herbal medicine is processed to obtain an extract; The raw materials are mixed with a solvent to obtain a mixed solution, wherein the raw materials include, by weight: 1-10 parts of nicotine active ingredient, 20-40 parts of the extract, 20-50 parts of sustained-release ingredients, 0.5-10 parts of a binder, 0.1-10 parts of a flavoring agent, 0.1-5 parts of a sweetener, and 0.1-5 parts of an acid-base regulator; The mixed solution is treated by a spray drying method to obtain the oral product.

7. The preparation method according to claim 6, characterized in that: The step of processing the expectorant and cough relieving Chinese herbal medicine to obtain the extract comprises: extracting the expectorant and cough relieving Chinese herbal medicine using a supercritical fluid extraction process.

8. The preparation method according to claim 7, characterized in that: The entrainer in the supercritical fluid extraction process is 50%-90% ethanol, the extraction pressure is 20MPa-40MPa, the temperature is 40°C-50°C, and the extraction time is 0.5h-2h.

9. The preparation method according to claim 6, characterized in that: The gas flow rate of the spray drying method for treating the mixed liquid is 20m 3 / h-40m 3 / h, the spray rate is 5mL / min-10mL / min, the heating temperature is 50℃-60℃, and the atomization pressure is 0.01MPa-0.05MPa.

10. The preparation method according to claim 6, characterized in that: The method of using a spray drying method to process the mixed solution to obtain the oral product comprises: The mixed solution is spray-dried to obtain solid particles, the water content of the solid particles is controlled at 10%-30%, and the solid particles are bagged to obtain the oral product; or The mixed liquid is spray-dried to obtain the solid particles, the solid particles are vacuum-dried to control the water content of the solid particles to be less than or equal to 7%, and the solid particles are bagged to obtain the oral product.

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