A cigarette containing traditional Chinese medicine and its preparation method

Abstract

This invention belongs to the field of tobacco technology, specifically relating to a cigarette containing traditional Chinese medicine and its preparation method. The cigarette comprises tobacco shreds loaded with amphiphilic cellulose porous material and the traditional Chinese medicine. The traditional Chinese medicine, by weight, includes: 150-200 parts of Ophiopogon japonicus, 130-180 parts of Atractylodes macrocephala, 100-150 parts of Cistanche deserticola, 40-80 parts of ginseng, 20-60 parts of Codonopsis pilosula, 20-40 parts of Rosa rugosa, 10-20 parts of Poria cocos, 10-20 parts of Aquilaria sinensis, and 5-15 parts of Morus alba bark. In this invention, Ophiopogon japonicus, Atractylodes macrocephala, and Cistanche deserticola are the principal herbs; ginseng, Codonopsis pilosula, and Rosa rugosa are the assistant herbs; Poria cocos and Aquilaria sinensis are the adjuvant herbs; and Morus alba bark is the guiding herb. This allows the cigarette containing the traditional Chinese medicine to have expectorant and antitussive effects. The use of tobacco shreds loaded with amphiphilic cellulose porous material improves the stability of the cigarette's efficacy.

Description

Technical Field

[0001] This invention belongs to the field of tobacco technology, specifically relating to a cigarette containing traditional Chinese medicine and its preparation method. Background Technology

[0002] As is well known, cigarettes release a large number of harmful substances when burned. When these harmful substances are inhaled, they adhere to the tracheal walls and alveoli, easily leading to bronchitis, emphysema, and even lung cancer. However, due to the presence of addictive chemicals in cigarettes, quitting smoking is a painful, repetitive, and long-term process, and most smokers are unable to quit completely.

[0003] To mitigate the harm of cigarettes, cigarettes containing traditional Chinese medicine have been continuously researched in recent years. For example, Chinese patent CN113519891A discloses a medicinal cigarette and its preparation method and equipment. The cigarette includes tobacco shreds filled inside the cigarette, which are composed of the following traditional Chinese medicine raw materials in the following weight proportions: 5-20 parts ginkgo leaves, 5-20 parts ginseng leaves, 5-20 parts lily leaves, 5-20 parts tea leaves, 5-20 parts wolfberry leaves, 5-20 parts jujube leaves, 5-20 parts fritillaria leaves, 5-20 parts loquat leaves; 3-10 parts dried tangerine peel; 3-10 parts astragalus extract, 5-15 parts polygonatum extract, 3-10 parts chuanxiong extract, and 2-10 parts licorice extract. This medicinal cigarette not only retains the shape and taste of a traditional cigarette but can also be brewed as a beverage. It also has the effects of moisturizing the lungs and nourishing yin, regulating the five internal organs, and refreshing the mind. However, this technical solution uses Chinese herbal medicine as tobacco and has a large number of components, which may affect the stability of the cigarette.

[0004] Chinese Patent CN103190694B discloses a traditional Chinese medicine extract, its preparation method, uses, and the resulting tobacco and cigarettes. The extract is prepared from agarwood, platycodon root, and licorice. This technical solution mixes the extract with tobacco to make cigarettes. During smoking, the extract volatilizes into the smoke at high temperatures and is inhaled by the smoker, thus achieving health benefits. The cigarettes have a pleasant aroma, can reduce throat irritation, eliminate bad breath, and have anti-inflammatory, lung-moistening, and anti-tumor effects. However, this technical solution directly mixes the extract with tobacco. The stability of the extract may differ from the properties of the tobacco, potentially leading to changes in the efficacy of the mixed product after storage. Summary of the Invention

[0005] To address the aforementioned problems, this invention provides a cigarette containing traditional Chinese medicine and its preparation method. The traditional Chinese medicine in this invention uses Ophiopogon japonicus, Atractylodes macrocephala, and Cistanche deserticola as principal herbs, ginseng, Codonopsis pilosula, and Rosa rugosa as assistant herbs, Poria cocos and Aquilaria sinensis as adjuvant herbs, and Morus alba bark as guiding herb. This allows the cigarette containing traditional Chinese medicine to have expectorant and antitussive effects. Furthermore, by loading tobacco shreds with amphiphilic cellulose porous material, the stability of the cigarette's efficacy is improved.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] The first aspect of the present invention provides a cigarette containing traditional Chinese medicine, comprising tobacco shreds loaded with amphiphilic cellulose porous material and traditional Chinese medicine; the traditional Chinese medicine, by weight, comprises: 150-200 parts of Ophiopogon japonicus, 130-180 parts of Atractylodes macrocephala, 100-150 parts of Cistanche deserticola, 40-80 parts of ginseng, 20-60 parts of Codonopsis pilosula, 20-40 parts of Prickly pear, 10-20 parts of Poria cocos, 10-20 parts of Aquilaria sinensis, and 5-15 parts of Morus alba bark.

[0008] Preferably, the content of the traditional Chinese medicine is 1-10% of the weight of the tobacco shreds, and more preferably 8%.

[0009] Preferably, the traditional Chinese medicine, by weight, includes: 180 parts of Ophiopogon japonicus, 160 parts of Atractylodes macrocephala, 130 parts of Cistanche deserticola, 60 parts of ginseng, 40 parts of Codonopsis pilosula, 30 parts of Prickly pear, 15 parts of Poria cocos, 15 parts of Agarwood, and 10 parts of Morus alba bark.

[0010] Preferably, the method for preparing the tobacco shreds loaded with amphiphilic cellulose porous material includes the following steps: stirring tobacco dust, binder, water and amphiphilic cellulose porous material to obtain tobacco sheet pulp, pressing the tobacco sheet pulp into sheets, rolling the sheets into shape, drying and shaping the rolled sheets, and cutting them into shreds.

[0011] Preferably, the preparation method of the amphiphilic cellulose porous material includes the following steps: mixing nanocellulose suspension and KH580 (γ-mercaptopropyltriethoxysilane), stirring, and freeze-drying to obtain the material.

[0012] Preferably, the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanocrystals in water at a mass ratio of 3-5:1.

[0013] Preferably, the cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm.

[0014] Preferably, the cellulose nanocrystals have a diameter of 4-10 nm and a length of 100-500 nm.

[0015] Preferably, the concentration of the nanocellulose suspension A is 1-3 wt%.

[0016] Preferably, the mass ratio of the cellulose nanofibers, cellulose nanocrystals and KH580 is 3-5:1:2-3, and more preferably 4:1:3.

[0017] Preferably, in the preparation method of amphiphilic cellulose porous material, the stirring temperature is 25-40℃ and the stirring time is 2-4h.

[0018] Preferably, in the preparation method of amphiphilic cellulose porous material, the freeze-drying temperature is -60 to -40°C, and the freeze-drying time is 24-48 hours.

[0019] Preferably, the tobacco dust includes one or more of flue-cured tobacco dust, sun-cured tobacco dust, aromatic tobacco dust, and burley tobacco dust.

[0020] Preferably, the adhesive comprises one or more of xanthan gum, chitosan, sodium alginate, and guar gum.

[0021] Preferably, the mass ratio of the tobacco dust, binder, water and amphiphilic cellulose porous material is 15-25:3-8:57-77:1-5, and more preferably 20:5:67:3.

[0022] Preferably, in the method for preparing tobacco shreds loaded with amphiphilic cellulose porous material, the stirring temperature is 25-30℃ and the stirring time is 20-40 min.

[0023] A second aspect of the present invention provides a method for preparing the above-mentioned cigarette, comprising the following steps:

[0024] S1. The following ingredients were crushed: Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis. They were then added to an ethanol aqueous solution, soaked, and heated under reflux to extract the extract I and volatile oil I.

[0025] S2. Ginseng and prickly pear are crushed, added to purified water, soaked, and heated under reflux to extract, yielding extract II and volatile oil II;

[0026] S3. Mix Codonopsis pilosula, Poria cocos, and Morus alba bark, add purified water, soak, and perform hot extraction 1-2 times. Combine the filtrates to obtain extract III.

[0027] S4. Mix volatile oil I and volatile oil II to obtain volatile oil III; mix extract III, extract II and extract III to obtain extract IV;

[0028] S5. First, spray volatile oil III onto the surface of the tobacco shreds and dry it. Then, spray extract IV onto the surface of the tobacco shreds and dry it. Finally, process the tobacco into cigarettes using conventional cigarette manufacturing processes.

[0029] Preferably, S1 specifically involves: pulverizing Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis, adding 8-12 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of ethanol aqueous solution, soaking at 50-70℃ for 1-2 hours, and heating and refluxing for 8-12 hours to obtain extract I and volatile oil I;

[0030] Preferably, the volume concentration of the ethanol aqueous solution is 85-95%.

[0031] Preferably, S2 specifically involves: pulverizing ginseng and prickly pear, adding 8-12 times (corresponding to the total mass of ginseng and prickly pear) of purified water, soaking at 50-70℃ for 1-2 hours, and then heating and refluxing for 8-12 hours to obtain extract II and volatile oil II;

[0032] Preferably, S3 specifically involves: mixing Codonopsis pilosula, Poria cocos, and Morus alba root bark, adding 8-12 times (corresponding to the total mass of Codonopsis pilosula, Poria cocos, and Morus alba root bark) of purified water, soaking at 50-70℃ for 1-2 hours, performing a first hot extraction at 90-100℃ for 1-2 hours, filtering the first extract, collecting the filtrate, adding 6-8 times the amount of purified water to the residue, performing a second hot extraction at 90-100℃ for 1-2 hours, and filtering the second extract.

[0033] Collect the filtrate and combine the two filtrates to obtain extract III.

[0034] Compared with the prior art, the present invention has the following beneficial effects:

[0035] 1. The traditional Chinese medicine of this invention uses Ophiopogon japonicus, Atractylodes macrocephala, and Cistanche deserticola as the principal herbs. Ophiopogon japonicus enters the heart, lung, and stomach meridians, moistening the lungs and clearing the heart, purging heat and generating fluids, resolving phlegm and stopping vomiting, treating cough and promoting urination; Atractylodes macrocephala enters the spleen and stomach meridians, strengthening the spleen and replenishing qi, drying dampness and promoting urination; Cistanche deserticola enters the kidney and large intestine meridians, resolving phlegm and stopping cough, improving lung heat cough and asthma; Ginseng, Codonopsis pilosula, and Rosa rugosa are the assistant herbs. Ginseng enters the spleen, lung, and heart meridians, tonifying the spleen and benefiting the lungs, and can assist Ophiopogon japonicus in moistening the lungs and clearing the heart, resolving phlegm and stopping cough; Codonopsis pilosula enters the spleen meridian, The lung meridian nourishes the middle jiao, replenishes qi, generates fluids, and benefits the lungs, assisting Atractylodes macrocephala in strengthening the spleen and replenishing qi; Prickly pear enters the spleen, kidney, and stomach meridians, and can help Cistanche deserticola moisten the lungs, resolve phlegm, and stop coughing; Poria cocos and Agarwood are adjuvants, Poria cocos enters the heart, lung, spleen, and kidney meridians, promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind, while Agarwood regulates qi, relieves pain, and opens the orifices, assisting Ophiopogon japonicus in moistening the lungs and clearing the heart, and Atractylodes macrocephala in strengthening the spleen and replenishing qi; Mulberry bark is the guiding herb, leading the principal and assistant herbs into their respective meridians, entering the lung and spleen meridians, purging the lungs and relieving asthma, and promoting diuresis and reducing swelling.

[0036] 2. The traditional Chinese medicine of this invention mainly consists of volatile oils from Ophiopogon japonicus, Atractylodes macrocephala, and Cistanche deserticola, which, in combination with other ingredients, enable the cigarette containing traditional Chinese medicine to have the effects of relieving phlegm and cough.

[0037] 3. This invention uses tobacco shreds loaded with amphiphilic cellulose porous material, which improves the efficacy and stability of cigarettes. Detailed Implementation

[0038] The present invention will be further illustrated below with reference to specific embodiments. It should be understood that the specific embodiments described herein are for illustrative and explanatory purposes only and are not intended to limit the present invention.

[0039] Unless otherwise specified, all raw materials used in the following examples are commercially available or prepared by conventional methods in the art.

[0040] Example 1

[0041] A cigarette containing traditional Chinese medicine comprises tobacco shreds loaded with amphiphilic cellulose porous material and traditional Chinese medicine; the content of the traditional Chinese medicine is 1% of the mass of the tobacco shreds, and the traditional Chinese medicine, by mass parts, consists of 150 parts of Ophiopogon japonicus, 130 parts of Atractylodes macrocephala, 100 parts of Cistanche deserticola, 40 parts of ginseng, 20 parts of Codonopsis pilosula, 20 parts of Prickly pear, 10 parts of Poria cocos, 10 parts of Agarwood, and 5 parts of Morus alba bark.

[0042] The method for preparing the tobacco shreds loaded with amphiphilic cellulose porous material includes the following steps: mixing burley tobacco powder, xanthan gum, water and amphiphilic cellulose porous material in a mass ratio of 15:3:77:1, stirring at a temperature of 25°C for 20 minutes to obtain tobacco sheet pulp, pressing the tobacco sheet pulp into sheets, rolling the sheets into shape, drying and shaping the rolled sheets, and cutting them into shreds.

[0043] The preparation method of the amphiphilic cellulose porous material includes the following steps: mixing a nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanocrystals in water at a mass ratio of 3:1, with a concentration of 1wt%) with KH580, stirring at 25°C for 2 hours, and freeze-drying at -60°C for 24 hours to obtain the material.

[0044] The cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm, and were purchased from Guilin Qihongke Co., Ltd.

[0045] The cellulose nanocrystals have a diameter of 4-10 nm and a length of 100-500 nm, and were purchased from Guilin Qihongke Co., Ltd.

[0046] The mass ratio of the cellulose nanofibers, cellulose nanowhiskers, and KH580 is 3:1:2.

[0047] The method for preparing the above-mentioned cigarettes includes the following steps:

[0048] S1. Pulverize Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis separately, add 8 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of 90% ethanol aqueous solution, soak at 50℃ for 1 hour, heat and reflux for 8 hours to extract, and obtain extract I and volatile oil I.

[0049] S2. Ginseng and prickly pear are crushed, and 8 times (corresponding to the total mass of ginseng and prickly pear) of purified water is added. The mixture is soaked at 50°C for 1 hour and then heated under reflux for 8 hours to obtain extract II and volatile oil II.

[0050] S3. Mix Codonopsis pilosula, Poria cocos, and Morus alba bark, add 8 times (corresponding to the total mass of Codonopsis pilosula, Poria cocos, and Morus alba bark) of purified water, soak at 50℃ for 1 hour, perform the first hot extraction at 90℃ for 1 hour, filter the first extract, collect the filtrate, add 6 times the amount of purified water to the residue, perform the second hot extraction at 90℃ for 1 hour, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0051] S4. Mix volatile oil I and volatile oil II to obtain volatile oil III; mix extract III, extract II and extract III to obtain extract IV;

[0052] S5. First, spray volatile oil III onto the surface of the tobacco shreds and dry it. Then, spray extract IV onto the surface of the tobacco shreds and dry it. Finally, process the tobacco into cigarettes using conventional cigarette manufacturing processes.

[0053] Example 2

[0054] A cigarette containing traditional Chinese medicine comprises tobacco shreds loaded with amphiphilic cellulose porous material and traditional Chinese medicine; the content of the traditional Chinese medicine is 10% of the mass of the tobacco shreds, and the traditional Chinese medicine, by mass parts, consists of 200 parts of Ophiopogon japonicus, 180 parts of Atractylodes macrocephala, 150 parts of Cistanche deserticola, 80 parts of ginseng, 60 parts of Codonopsis pilosula, 40 parts of Prickly pear, 20 parts of Poria cocos, 20 parts of Agarwood, and 15 parts of Morus alba bark.

[0055] The method for preparing the tobacco shreds loaded with amphiphilic cellulose porous material includes the following steps: mixing burley tobacco powder, xanthan gum, water and amphiphilic cellulose porous material in a mass ratio of 25:8:57:5, stirring at a temperature of 30°C for 40 minutes to obtain tobacco sheet pulp, pressing the tobacco sheet pulp into sheets, rolling the sheets into shape, drying and shaping the rolled sheets, and cutting them into shreds.

[0056] The preparation method of the amphiphilic cellulose porous material includes the following steps: mixing a nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanocrystals in water at a mass ratio of 5:1, with a concentration of 3wt%) with KH580, stirring at 40°C for 4 hours, and freeze-drying at -40°C for 48 hours to obtain the material.

[0057] The cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm, and were purchased from Guilin Qihongke Co., Ltd.

[0058] The cellulose nanocrystals have a diameter of 4-10 nm and a length of 100-500 nm, and were purchased from Guilin Qihongke Co., Ltd.

[0059] The mass ratio of the cellulose nanofibers, cellulose nanowhiskers, and KH580 is 5:1:3.

[0060] The method for preparing the above-mentioned cigarettes includes the following steps:

[0061] S1. Pulverize Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis separately, add 12 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of 90% ethanol aqueous solution, soak at 70℃ for 2 hours, heat and reflux for 12 hours to extract, and obtain extract I and volatile oil I.

[0062] S2. Ginseng and prickly pear are crushed, and 12 times (corresponding to the total mass of ginseng and prickly pear) of purified water is added. The mixture is soaked at 70℃ for 2 hours and then heated under reflux for 12 hours to obtain extract II and volatile oil II.

[0063] S3. Mix Codonopsis pilosula, Poria cocos, and Morus alba bark, add 12 times (corresponding to the total mass of Codonopsis pilosula, Poria cocos, and Morus alba bark) of purified water, soak at 70℃ for 2 hours, perform the first hot extraction at 100℃ for 2 hours, filter the first extract, collect the filtrate, add 8 times the amount of purified water to the residue, perform the second hot extraction at 100℃ for 2 hours, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0064] S4. Mix volatile oil I and volatile oil II to obtain volatile oil III; mix extract III, extract II and extract III to obtain extract IV;

[0065] S5. First, spray volatile oil III onto the surface of the tobacco shreds and dry it. Then, spray extract IV onto the surface of the tobacco shreds and dry it. Finally, process the tobacco into cigarettes using conventional cigarette manufacturing processes.

[0066] Example 3

[0067] A cigarette containing traditional Chinese medicine comprises tobacco shreds loaded with amphiphilic cellulose porous material and traditional Chinese medicine; the content of the traditional Chinese medicine is 10% of the mass of the tobacco shreds, and the traditional Chinese medicine, by mass parts, consists of 180 parts of Ophiopogon japonicus, 160 parts of Atractylodes macrocephala, 130 parts of Cistanche deserticola, 60 parts of ginseng, 40 parts of Codonopsis pilosula, 30 parts of Prickly pear, 15 parts of Poria cocos, 15 parts of Agarwood, and 10 parts of Morus alba bark.

[0068] The method for preparing the tobacco shreds loaded with amphiphilic cellulose porous material includes the following steps: mixing burley tobacco powder, xanthan gum, water and amphiphilic cellulose porous material in a mass ratio of 20:5:67:3, stirring at a temperature of 30°C for 30 minutes to obtain tobacco sheet pulp, pressing the tobacco sheet pulp into sheets, rolling the sheets into shape, drying and shaping the rolled sheets, and cutting them into shreds.

[0069] The preparation method of the amphiphilic cellulose porous material includes the following steps: mixing a nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanocrystals in water at a mass ratio of 4:1, with a concentration of 2wt%) with KH580, stirring at 35°C for 3 hours, and freeze-drying at -50°C for 36 hours to obtain the material.

[0070] The cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 μm, and were purchased from Guilin Qihongke Co., Ltd.

[0071] The cellulose nanocrystals have a diameter of 4-10 nm and a length of 100-500 nm, and were purchased from Guilin Qihongke Co., Ltd.

[0072] The mass ratio of the cellulose nanofibers, cellulose nanowhiskers, and KH580 is 4:1:3.

[0073] The method for preparing the above-mentioned cigarettes includes the following steps:

[0074] S1. Pulverize Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis separately, add 10 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of 90% ethanol aqueous solution, soak at 60℃ for 1.5h, heat and reflux for 10h to extract, and obtain extract I and volatile oil I.

[0075] S2. Ginseng and prickly pear are crushed, and 10 times (corresponding to the total mass of ginseng and prickly pear) of purified water is added. The mixture is soaked at 60℃ for 1.5h and then heated under reflux for 10h to obtain extract II and volatile oil II.

[0076] S3. Mix Codonopsis pilosula, Poria cocos, and Morus alba root bark, add 10 times (corresponding to the total mass of Codonopsis pilosula, Poria cocos, and Morus alba root bark) of purified water, soak at 65℃ for 1.5h, perform the first hot extraction at 100℃ for 1.5h, filter the first extract, collect the filtrate, add 8 times the amount of purified water to the residue, perform the second hot extraction at 100℃ for 1.5h, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0077] S4. Mix volatile oil I and volatile oil II to obtain volatile oil III; mix extract III, extract II and extract III to obtain extract IV;

[0078] S5. First, spray volatile oil III onto the surface of the tobacco shreds and dry it. Then, spray extract IV onto the surface of the tobacco shreds and dry it. Finally, process the tobacco into cigarettes using conventional cigarette manufacturing processes.

[0079] Comparative Example 1

[0080] The only difference from Example 3 is that the Cistanche deserticola is replaced with an equal amount of ginseng, while everything else is the same.

[0081] Comparative Example 2

[0082] The only difference from Example 3 is that the ginseng is replaced with an equal amount of licorice, while everything else remains the same.

[0083] Comparative Example 3

[0084] The only difference from Example 3 is that the agarwood is replaced with an equal amount of Poria cocos; everything else is the same.

[0085] Comparative Example 4

[0086] The only difference from Example 4 is that the mulberry bark is replaced with an equal amount of dried tangerine peel; everything else is the same.

[0087] Comparative Example 5

[0088] The difference from Example 3 is that the method for preparing the cigarette includes the following steps:

[0089] S1. Mix Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, Agarwood, Ginseng, Rosa rugosa, Codonopsis pilosula, Poria cocos, and Morus alba bark. Add 10 times the amount of purified water (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, Agarwood, Ginseng, Rosa rugosa, Codonopsis pilosula, Poria cocos, and Morus alba bark) and soak at 70℃ for 2 hours. Perform the first hot extraction at 100℃ for 2 hours. Filter the first extract and collect the filtrate. Add 8 times the amount of purified water to the residue and perform the second hot extraction at 100℃ for 2 hours. Filter the second extract and collect the filtrate. Combine the two filtrates to obtain the extract.

[0090] S2. Spray the extract onto the surface of the tobacco shreds, dry them, and then process them into cigarettes using conventional cigarette manufacturing processes.

[0091] Comparative Example 6

[0092] The only difference from Example 3 is that the tobacco shreds loaded with amphiphilic cellulose porous material are replaced with an equal mass of burley tobacco shreds; all other aspects are the same.

[0093] Comparative Example 7

[0094] The difference from Example 3 is that only the amphiphilic cellulose porous material is replaced with an equal mass of cellulose porous material, and everything else is the same. The cellulose porous material is prepared by freeze-drying a nanocellulose suspension (the nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanocrystals in water at a mass ratio of 4:1, with a concentration of 2wt%) at -50°C for 36 hours.

[0095] Comparative Example 8

[0096] The difference from Example 3 is that the cigarette is made from tobacco shreds loaded with amphiphilic cellulose porous material (the content of amphiphilic cellulose porous material is 3% of the mass of the tobacco shreds) using conventional cigarette manufacturing processes.

[0097] Comparative Example 9

[0098] The difference from Example 3 is that the method for preparing the cigarette includes the following steps:

[0099] S1. Pulverize Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis separately, add 10 times (corresponding to the total mass of Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis) of 90% ethanol aqueous solution, soak at 60℃ for 1.5h, heat and reflux for 10h to extract, and obtain extract I and volatile oil I.

[0100] S2. Ginseng and prickly pear are crushed, and 10 times (corresponding to the total mass of ginseng and prickly pear) of purified water is added. The mixture is soaked at 60℃ for 1.5h and then heated under reflux for 10h to obtain extract II and volatile oil II.

[0101] S3. Mix Codonopsis pilosula, Poria cocos, and Morus alba root bark, add 10 times (corresponding to the total mass of Codonopsis pilosula, Poria cocos, and Morus alba root bark) of purified water, soak at 65℃ for 1.5h, perform the first hot extraction at 100℃ for 1.5h, filter the first extract, collect the filtrate, add 8 times the amount of purified water to the residue, perform the second hot extraction at 100℃ for 1.5h, filter the second extract, collect the filtrate, and combine the two filtrates to obtain extract III.

[0102] S4. Mix volatile oil I and volatile oil II to obtain volatile oil III; mix extract III, extract II and extract III to obtain extract IV; reduce the pressure of extract IV to a relative density of 1.1 (50℃) to obtain a thick extract, dry and pulverize to obtain the extract;

[0103] S5. First, spray volatile oil III onto the surface of the tobacco shreds, dry it, and then mix the extract with the tobacco shreds and make cigarettes according to the conventional cigarette manufacturing process.

[0104] Experiment Example 1: Cough Relief and Expectorant Experiment

[0105] 1. Laboratory animals

[0106] SPF-grade Kunming mice, half male and half female, weighing 20±5g, were provided by Liaoning Changsheng Biotechnology Co., Ltd.

[0107] 2. Experimental Methods

[0108] 2.1 Grouping

[0109] Mice were randomly divided into a blank group, Example 1-3 groups, and Comparative Example 1-9 groups, with 10 mice in each group, half male and half female.

[0110] 2.2 Experiment

[0111] The control group was raised normally without smoke. Examples 1-3 and Comparative Examples 1-9 were each placed in a smoke-smoking wooden box. Two cigarettes from Examples 1-3 and Comparative Examples 1-9 were lit each time and placed on a mosquito coil dish in the wooden box, twice daily for 30 minutes each time. The following tests were performed after 30 days of smoke-smoking:

[0112] (1) 30 minutes after the last experiment, observe the changes in the number of coughs in mice within 5 minutes and record the number of coughs in each group of mice.

[0113] (2) After the last experiment, six mice were taken from each group and injected intraperitoneally with 10 mL / kg of 5% phenol red solution. The mice were sacrificed 30 min later, the tracheal segment was separated, the thyroid cartilage was taken to the tracheal branch, cut into pieces, and placed in a test tube of 4 mL of 5% NaHCO3 solution. The solution was soaked for 4 h, centrifuged at 3000 r / min for 15 min, the supernatant was taken, and the OD value was measured at a wavelength of 546 nm. The phenol red content was calculated using the phenol red standard curve.

[0114] 2.3 Statistical Methods

[0115] All data were analyzed using SPSS 22.0 statistical software, and the statistical measures were calculated using... This indicates that the comparisons between groups were performed using one-way ANOVA, and P < 0.05 was considered statistically significant.

[0116] 3. Experimental Results

[0117] Table 1. Results of the cough-suppressing and expectorant experiments.

[0118]

[0119] As shown in Table 1, there was a significant difference between Comparative Example 8 and the blank group, indicating that the model was successfully established. The cough-suppressing and expectorant effects of Example 1-3, Comparative Example 6-7, and Comparative Example 9 were significantly different from those of Comparative Example 8. There was no significant difference between Comparative Example 1-5 and Comparative Example 8, indicating that Example 1-3, Comparative Example 6-7, and Comparative Example 9 can effectively suppress cough and expectorate.

[0120] The difference between Comparative Examples 1-4 and Example 3 lies in the different types of medicinal materials, and the difference between Comparative Example 5 and Example 1 lies in the different preparation methods of the drugs in the cigarettes. The drugs are all in the form of water extracts. Therefore, it can be concluded that in this invention, the type and preparation method of traditional Chinese medicine both affect the antitussive and expectorant effects of cigarettes.

[0121] Experiment Example 2: Stability Experiment

[0122] Cigarettes from Examples 1-3 and Comparative Examples 6-9 were placed under natural conditions for 12 months, and then subjected to the same experiment as in Experiment 1. Their stability was evaluated by their antitussive and expectorant effects.

[0123] Table 2. Results of cough suppression and expectoration after 12 months of placement.

[0124]

[0125] As shown in Table 2, there was a significant difference between Comparative Example 8 and the blank group, indicating that the model was successfully established. After being placed under natural conditions for 6 months, there was a significant difference between the antitussive and expectorant effects of Examples 1-3 and Comparative Example 8. There was no significant difference between Comparative Example 6-7 and Comparative Example 9 and Comparative Example 8, indicating that the cigarettes in Examples 1-3 have good stability.

[0126] The difference between Comparative Examples 6-7 and Example 3 lies in the different tobacco shreds in the cigarettes. The difference between Comparative Example 9 and Example 3 lies in the different preparation methods of the cigarettes (the different mixing methods of traditional Chinese medicine and tobacco shreds). It can be concluded that in this invention, both the tobacco shreds loaded with amphiphilic cellulose porous material and the preparation method affect the antitussive and expectorant effects of the cigarettes.

[0127] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A cigarette containing traditional Chinese medicine, characterized in that, This includes tobacco and traditional Chinese medicine loaded with amphiphilic cellulose porous materials; The Chinese medicinal herbs, by weight, include: 150-200 parts of Ophiopogon japonicus, 130-180 parts of Atractylodes macrocephala, 100-150 parts of Cistanche deserticola, 40-80 parts of Panax ginseng, 20-60 parts of Codonopsis pilosula, 20-40 parts of Rosa rugosa, 10-20 parts of Poria cocos, 10-20 parts of Aquilaria sinensis, and 5-15 parts of Morus alba bark; The method for preparing the tobacco shreds loaded with amphiphilic cellulose porous material includes the following steps: stirring tobacco powder, binder, water and amphiphilic cellulose porous material to obtain tobacco sheet slurry, pressing the tobacco sheet slurry into sheets, rolling the sheets into shape, drying and shaping the rolled sheets, and cutting them into shreds to obtain the tobacco shreds. The preparation method of the amphiphilic cellulose porous material includes the following steps: mixing nanocellulose suspension and KH580, stirring, and freeze-drying to obtain the material; The nanocellulose suspension is obtained by dispersing cellulose nanofibers and cellulose nanocrystals in water at a mass ratio of 3-5:

1. The method for preparing the cigarette includes the following steps: S1. The following ingredients were crushed: Ophiopogon japonicus, Atractylodes macrocephala, Cistanche deserticola, and Aquilaria sinensis. They were then added to an ethanol aqueous solution, soaked, and heated under reflux to extract the extract I and volatile oil I. S2. Ginseng and prickly pear are crushed, added to purified water, soaked, and heated under reflux to extract, yielding extract II and volatile oil II; S3. Mix Codonopsis pilosula, Poria cocos, and Morus alba bark, add purified water, soak, and perform hot extraction 1-2 times. Combine the filtrates to obtain extract III. S4. Mix volatile oil I and volatile oil II to obtain volatile oil III; mix extract I, extract II and extract III to obtain extract IV; S5. First, spray volatile oil III onto the surface of tobacco shreds loaded with amphiphilic cellulose porous material, and dry it. Then, spray extract IV onto the surface of tobacco shreds loaded with amphiphilic cellulose porous material, and dry it to make cigarettes.

2. The cigarette according to claim 1, characterized in that, The Chinese medicinal herbs, by weight, include: 180 parts of Ophiopogon japonicus, 160 parts of Atractylodes macrocephala, 130 parts of Cistanche deserticola, 60 parts of ginseng, 40 parts of Codonopsis pilosula, 30 parts of Prickly pear, 15 parts of Poria cocos, 15 parts of Agarwood, and 10 parts of Morus alba bark.

3. The cigarette according to claim 2, characterized in that, The content of the Chinese herbal medicine is 1-10% of the weight of the tobacco.

4. The cigarette according to claim 1, wherein the mass ratio of the cellulose nanofibers, cellulose nanocrystals and KH580 is 3-5:1:2-3.

5. The cigarette according to claim 4, characterized in that, The cellulose nanofibers are carboxylated cellulose nanofibers with a diameter of 4-10 nm and a length of 1-3 µm; the cellulose nanowhiskers have a diameter of 4-10 nm and a length of 100-500 nm.

6. The cigarette according to claim 1, characterized in that, The mass ratio of the tobacco dust, binder, water, and amphiphilic cellulose porous material is 15-25:3-8:57-77:1-5.

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