Composition with whitening and acne mark removing effects as well as preparation method and application thereof

By using the reclaimed composition of plant extracts such as Clampoors in cosmetics, combined with other skin conditioning agents, the problems of the existing cosmetics whitening, acne removal and acne marks have been solved. The effect of whitening, acne and acne marks.

CN119345082AActive Publication Date: 2025-01-24GUANGDONG KEYING TECH CO LTD
View PDF 6 Cites 0 Cited by

Patent Information

Application Number
CN202411492129.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-24
Publication Date
2025-01-24
Estimated Expiration
2044-10-24

AI Technical Summary

Technical Problem

Existing cosmetics are difficult to effectively whiten, remove acne and remove acne marks, and they are slow to achieve and cannot meet the needs of consumers.

Method used

Clampstroke extract, white willow bark extract, yellow cricket bark extract, Houttuynia cordie extract, raspberry extract, combined with almond acid, nicotinamide, alpha-beefin, beet-alkali, covering Pot ketone glucoside and other components form a composition with whitening, acne and acne marks.

Benefits of technology

Realize a significant whitening effect, significantly inhibit acne propiner, quickly remove acne, and quickly repair acne marks by inhibiting the activity of elastic proteases to improve the flatness and smoothness of the skin.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure BDA0005100355910000091
    Figure BDA0005100355910000091
  • Figure BDA0005100355910000092
    Figure BDA0005100355910000092
Patent Text Reader

Abstract

The invention relates to the technical field of cosmetic raw materials, and particularly discloses a composition with whitening and acne mark removing effects as well as a preparation method and application thereof. The invention relates to a composition with whitening and acne mark removing effects. The composition comprises the following components in parts by mass: 21.5-23.5 parts of a solvent; 1.8 to 2.2 parts of a penetration enhancer; 0.4 to 0.6 part of a stabilizer; 0.9 to 1.1 parts of an emulsifier; 56.6 to 63.4 parts of a composite extract; 12.3 to 15.7 parts of a skin conditioning agent; the composite extract is compounded by centella asiatica extract, white willow bark extract, amur corktree bark extract, cordate houttuynia extract and raspberry extract. The method has the advantage that the whitening and acne removing effects of cosmetics are further improved.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] The invention relates to the field of cosmetic raw materials, and in particular to a composition with whitening and acne scar removal effects, a preparation method and an application thereof. Background Art

[0002] Cosmetics are one of the important products used to repair the skin. With the development of technology, cosmetics are no longer a luxury item, but have become a mass consumer product with a large consumer group. Therefore, the large consumer group has also brought about the diversity of skin problems. Targeted solution to skin problems is the development direction of cosmetics.

[0003] Acne is mainly a skin problem caused by the accumulation of oil in the skin's hair follicles, which leads to the growth of bacteria. After the acne subsides, it is easy to leave acne marks on the skin, which seriously affects the appearance. With the acceleration of the social pace, modern young people have a higher frequency of acne, resulting in acne removal, whitening, and acne mark removal becoming an urgent need for consumers.

[0004] Whitening ingredients and antibacterial ingredients are added to existing cosmetics to achieve certain acne-removing and whitening effects. However, both the whitening and acne-removing effects are relatively general and take effect slowly, which is difficult to meet the needs of consumers. Therefore, there is still room for improvement. Summary of the invention

[0005] In order to further improve the whitening and acne-removing effects of cosmetics, the present application provides a composition with whitening and acne-removing effects, a preparation method thereof, and an application thereof.

[0006] In the first aspect, the present application provides a composition having the effect of whitening and removing acne marks, which adopts the following technical scheme: A composition with the effect of whitening and removing acne marks, comprising the following components in parts by weight: Solvent 21.5-23.5 parts; 1.8-2.2 parts of penetration enhancer; Stabilizer 0.4-0.6 parts; Emulsifier 0.9-1.1 parts; Composite extract 56.6-63.4 parts; Skin conditioning agent 13.3-20.7 parts; The composite extract is a compound of Centella asiatica extract, Salix alba bark extract, Phellodendron amurense bark extract, Houttuynia cordata extract and Raspberry extract.

[0007] By adopting the above technical scheme, through the compounding of Centella asiatica extract, white willow bark extract, Phellodendron chinense bark extract, Houttuynia cordata extract and raspberry extract, various active ingredients can play a significant whitening effect after cooperating with each other, and have a very significant inhibitory effect on Propionibacterium acnes, and can play a good whitening and acne-removing effect. Moreover, various active ingredients can also well inhibit the activity of elastase after cooperating with each other, so that the skin can better restore elasticity, so that the acne marks after the acne is eliminated can be quickly repaired, and the skin can be restored to be smooth and flat, which well meets the needs of consumers.

[0008] Preferably, the mass ratio of the Centella asiatica extract, the Salix alba bark extract, the Phellodendron chinense bark extract, the Houttuynia cordata extract, and the Rubus idaeus extract is 2.8-3.2:24-26:14-16:14-16:1.8-2.2.

[0009] By adopting the above technical scheme and specifically selecting the mass ratio of Centella asiatica extract, willow bark extract, phellodendron chinense bark extract, houttuynia cordata extract and raspberry extract, various active ingredients are combined in a specific ratio to exert a better synergistic effect, and the effects of whitening, acne removal and acne scar removal are more significant and take effect faster.

[0010] Preferably, the skin conditioning agent is a compound of mandelic acid, niacinamide, α-arbutin, betaine and raspberry ketone glucoside.

[0011] By adopting the above technical solution and adding mandelic acid, niacinamide, α-arbutin, betaine and raspberry ketone glucoside, the whitening effect can be further improved, making the skin whitening effect better.

[0012] Preferably, the mass ratio of mandelic acid, nicotinamide, α-arbutin, betaine and raspberry ketone glucoside is 3.5-4.5:2.5-3.5:0.8-1.2:5.5-6.5:1-5.

[0013] By adopting the above technical scheme and specifically selecting the mass ratio of mandelic acid, niacinamide, α-arbutin, betaine and raspberry ketone glucoside, the whitening effect is further improved and the effect is more rapid.

[0014] Preferably, the solvent is a mixture of deionized water and isoprene glycol.

[0015] By adopting the above technical scheme and specifically selecting the solvent as a compound of deionized water and isoprene glycol, the solubility of each component in the solvent is high, the product quality is uniform, and the synergistic effect of each component can be better exerted, so that the effects of whitening, acne removal and acne mark removal are better.

[0016] Preferably, the mass ratio of the deionized water to isoprene glycol is 17-18:4.5-5.5.

[0017] By adopting the above technical solution and specifically selecting the mass ratio of deionized water and isoprene glycol, the solubility of the solvent is higher, the raw materials are better mixed, and the synergistic effect is better.

[0018] Preferably, the penetration enhancer is lauroyl azolam, the stabilizer is p-hydroxyacetophenone, and the emulsifier is decyl glucoside.

[0019] By adopting the above technical scheme, by specifically selecting lauroyl azolam as the penetration enhancer, p-hydroxyacetophenone as the stabilizer, and decyl glucoside as the emulsifier, the product quality is more stable and easier to be absorbed by the skin, and the product has more significant effects on skin whitening, acne removal, and acne mark removal.

[0020] In a second aspect, the present application provides a method for preparing a composition having the effect of whitening and removing acne scars, using the following technical solution: A preparation method of the above-mentioned composition with the effect of whitening and removing acne marks comprises the following steps: uniformly mixing a solvent, a penetration enhancer, a stabilizer, an emulsifier, a composite extract and a skin conditioner to obtain the composition with the effect of whitening and removing acne marks.

[0021] By adopting the above technical scheme, the prepared composition with the effect of whitening and removing acne marks can achieve the effects of rapid whitening, removing acne and removing acne marks, quickly repair the skin, and make the skin white and smooth.

[0022] In a third aspect, the present application provides an application of a composition having the effect of whitening and removing acne marks, using the following technical solution: An application of the above-mentioned composition with whitening and acne scar removal effect, wherein the composition with whitening and acne scar removal effect is added to cosmetics to prepare cosmetics with whitening and acne scar removal effect, and the mass content of the composition with whitening and acne scar removal effect in the cosmetics is 1-5%.

[0023] By adopting the above technical solution, by adding 1-5% of the composition with whitening and acne scar removal effect into cosmetics, the cosmetics can have the effects of rapid whitening, acne removal and acne scar removal, the product quality is better, the cost is lower, and it is conducive to promotion.

[0024] In summary, this application has the following beneficial effects: 1. Since the present application uses a compound of Centella asiatica extract, willow bark extract, phellodendron chinense bark extract, houttuynia cordata extract, and raspberry extract, the various active ingredients can play a significant whitening effect after working together, and have a very significant inhibitory effect on Propionibacterium acnes, and can play a good whitening and acne-removing effect. In addition, the various active ingredients can also well inhibit the activity of elastase after working together, so that the skin can better restore elasticity, so that the acne marks after acne is eliminated can be quickly repaired, and the skin can be restored to be smooth and flat, which well meets the needs of consumers.

[0025] 2. In the present application, it is preferred to specifically select the mass ratio of Centella asiatica extract, willow bark extract, phellodendron chinense bark extract, houttuynia cordata extract, and raspberry extract so that various active ingredients are combined in a specific ratio to achieve a better synergistic effect, and the effects of whitening, acne removal, and acne scar removal are more significant and take effect faster.

[0026] 3. In the present application, it is preferred to add mandelic acid, niacinamide, α-arbutin, betaine, and raspberry ketone glucoside to further enhance the whitening effect and achieve a better skin whitening effect. DETAILED DESCRIPTION

[0027] The present application is further described in detail below in conjunction with embodiments.

[0028] Example 1 A composition with the effect of whitening and removing acne marks, comprising the following components: Solvent, penetration enhancer, stabilizer, emulsifier, complex extract, skin conditioner.

[0029] The solvent is a mixture of deionized water and isoprene glycol.

[0030] Isopentyl glycol is commercially available, CAS number: 2568-33-4.

[0031] The penetration enhancer is lauroyl azolam, which is commercially available with CAS number: 59227-89-3.

[0032] The stabilizer is p-hydroxyacetophenone, which is commercially available and has a CAS number of 99-93-4.

[0033] The emulsifier is decyl glucoside, which is commercially available with CAS number: 68515-73-1.

[0034] The compound extract is a combination of Centella asiatica extract, white willow bark extract, phellodendron chinense bark extract, houttuynia cordata extract, and raspberry extract.

[0035] Centella asiatica extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0036] The white willow bark extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0037] The Phellodendron chinense bark extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0038] Houttuynia cordata extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0039] Raspberry extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0040] The skin conditioning agent is a combination of mandelic acid, niacinamide, α-arbutin, betaine, and raspberry ketone glucoside.

[0041] Mandelic acid is commercially available, CAS number: 90-64-2.

[0042] Nicotinamide is commercially available, CAS number: 98-92-0.

[0043] α-Arbutin is commercially available, CAS number: 84380-01-8.

[0044] Betaine is commercially available, CAS number: 107-43-7.

[0045] Raspberry ketone glucoside is commercially available, CAS number: 38963-94-9.

[0046] The preparation method of the composition having the effect of whitening and removing acne marks is as follows: Step 1), 4.5 kg of isopentyl glycol, 2.5 kg of nicotinamide, 1.8 kg of lauroyl azoline, 5.5 kg of betaine, 1 kg of raspberry ketone glucoside, 3.5 kg of mandelic acid, 0.4 kg of p-hydroxyacetophenone, 0.9 kg of decyl glucoside, and 17 kg of deionized water are put into an emulsifying pot, heated to 85 ° C, rotated at 120 r / min, stirred for 15 min, stirred evenly, and obtained a premix.

[0047] Step 2), cool the premix to 40°C, add 1.8kg raspberry extract, 0.8kg α-arbutin, 2.8kg Centella asiatica extract, 24kg willow bark extract, 14kg Phellodendron chinense bark extract, 14kg Houttuynia cordata extract, rotate at 60r / min, stir for 30min, stir evenly, and obtain a composition with whitening and acne scar removal effect.

[0048] Example 2 A composition with the effect of whitening and removing acne marks, comprising the following components: Solvent, penetration enhancer, stabilizer, emulsifier, complex extract, skin conditioner.

[0049] The solvent is a mixture of deionized water and isoprene glycol.

[0050] Isopentyl glycol is commercially available, CAS number: 2568-33-4.

[0051] The penetration enhancer is lauroyl azolam, which is commercially available with CAS number: 59227-89-3.

[0052] The stabilizer is p-hydroxyacetophenone, which is commercially available and has a CAS number of 99-93-4.

[0053] The emulsifier is decyl glucoside, which is commercially available with CAS number: 68515-73-1.

[0054] The compound extract is a combination of Centella asiatica extract, white willow bark extract, phellodendron chinense bark extract, houttuynia cordata extract, and raspberry extract.

[0055] Centella asiatica extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0056] The white willow bark extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0057] The Phellodendron chinense bark extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0058] Houttuynia cordata extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0059] Raspberry extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0060] The skin conditioning agent is a combination of mandelic acid, niacinamide, α-arbutin, betaine, and raspberry ketone glucoside.

[0061] Mandelic acid is commercially available, CAS number: 90-64-2.

[0062] Nicotinamide is commercially available, CAS number: 98-92-0.

[0063] α-Arbutin is commercially available, CAS number: 84380-01-8.

[0064] Betaine is commercially available, CAS number: 107-43-7.

[0065] Raspberry ketone glucoside is commercially available, CAS number: 38963-94-9.

[0066] The preparation method of the composition having the effect of whitening and removing acne marks is as follows: Step 1), 5 kg of isopentyl glycol, 3 kg of nicotinamide, 2 kg of lauroyl azolam, 5 kg of betaine, 2.5 kg of raspberry ketone glucoside, 4 kg of mandelic acid, 0.5 kg of p-hydroxyacetophenone, 1 kg of decyl glucoside, and 17.5 kg of deionized water are put into an emulsifying pot, heated to 90 ° C, rotated at 120 r / min, stirred for 15 minutes, and stirred evenly to obtain a premix.

[0067] Step 2), cool the premix to 44°C, add 2kg raspberry extract, 1kg α-arbutin, 3kg Centella asiatica extract, 25kg willow bark extract, 15kg Phellodendron chinense bark extract, 15kg Houttuynia cordata extract, rotate at 60r / min, stir for 30min, stir evenly, and obtain a composition with whitening and acne scar removal effect.

[0068] Example 3 A composition with the effect of whitening and removing acne marks, comprising the following components: Solvent, penetration enhancer, stabilizer, emulsifier, complex extract, skin conditioner.

[0069] The solvent is a mixture of deionized water and isoprene glycol.

[0070] Isopentyl glycol is commercially available, CAS number: 2568-33-4.

[0071] The penetration enhancer is lauroyl azolam, which is commercially available with CAS number: 59227-89-3.

[0072] The stabilizer is p-hydroxyacetophenone, which is commercially available and has a CAS number of 99-93-4.

[0073] The emulsifier is decyl glucoside, which is commercially available with CAS number: 68515-73-1.

[0074] The compound extract is a combination of Centella asiatica extract, white willow bark extract, phellodendron chinense bark extract, houttuynia cordata extract, and raspberry extract.

[0075] Centella asiatica extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0076] The white willow bark extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0077] The Phellodendron chinense bark extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0078] Houttuynia cordata extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0079] Raspberry extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0080] The skin conditioning agent is a combination of mandelic acid, niacinamide, α-arbutin, betaine, and raspberry ketone glucoside.

[0081] Mandelic acid is commercially available, CAS number: 90-64-2.

[0082] Nicotinamide is commercially available, CAS number: 98-92-0.

[0083] α-Arbutin is commercially available, CAS number: 84380-01-8.

[0084] Betaine is commercially available, CAS number: 107-43-7.

[0085] Raspberry ketone glucoside is commercially available, CAS number: 38963-94-9.

[0086] The preparation method of the composition having the effect of whitening and removing acne marks is as follows: Step 1), 5.5 kg of isopentyl glycol, 3.5 kg of nicotinamide, 2.2 kg of lauroyl azolam, 6.5 kg of betaine, 5 kg of raspberry ketone glucoside, 4.5 kg of mandelic acid, 0.6 kg of p-hydroxyacetophenone, 1.1 kg of decyl glucoside, and 18 kg of deionized water are put into an emulsifying pot, heated to 95 ° C, rotated at 120 r / min, stirred for 15 min, stirred evenly, and obtained a premix.

[0087] Step 2), cool the premix to 48°C, add 2.2kg raspberry extract, 1.2kg α-arbutin, 3.2kg Centella asiatica extract, 26kg willow bark extract, 16kg Phellodendron chinense bark extract, 16kg Houttuynia cordata extract, rotate at 60r / min, stir for 30min, stir evenly, and obtain a composition with whitening and acne scar removal effect.

[0088] Comparative Example 1 A composition with the effect of whitening and removing acne marks, compared with Example 2, the only difference is: In the composite extract, an equal amount of licorice extract is used to replace the Centella asiatica extract.

[0089] Licorice extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0090] Comparative Example 2 A composition with the effect of whitening and removing acne marks, compared with Example 2, the only difference is: In the composite extract, the white willow bark extract is replaced by an equal amount of purslane extract.

[0091] Purslane extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0092] Comparative Example 3 A composition with the effect of whitening and removing acne marks, compared with Example 2, the only difference is: In the composite extract, an equal amount of Scutellaria baicalensis root extract was used to replace the Phellodendron amurense bark extract.

[0093] The scutellaria root extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0094] Comparative Example 4 A composition with the effect of whitening and removing acne marks, compared with Example 2, the only difference is: In the composite extract, chamomile extract is used to replace Houttuynia cordata extract in an equal amount.

[0095] Chamomile extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0096] Comparative Example 5 A composition with the effect of whitening and removing acne marks, compared with Example 2, the only difference is: In the composite extract, an equal amount of glycyrrhiza glabra extract is used to replace raspberry extract.

[0097] The extract of Glycyrrhiza glabra was purchased from Shaanxi Bolin Biotechnology Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0098] Comparative Example 6 A composition with the effect of whitening and removing acne marks, compared with Example 2, the only difference is: In the composite extract, licorice extract is used to replace Centella asiatica extract in an equal amount; Portulaca oleracea extract is used to replace Salix alba bark extract in an equal amount; Scutellaria baicalensis root extract is used to replace Phellodendron chinense bark extract in an equal amount; Chamomile extract is used to replace Houttuynia cordata extract in an equal amount; Glycyrrhiza glabra extract is used to replace raspberry extract in an equal amount.

[0099] Licorice extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0100] Purslane extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0101] The scutellaria root extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0102] Chamomile extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0103] The extract of Glycyrrhiza glabra was purchased from Shaanxi Bolin Biotechnology Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0104] Experiment 1 A number of volunteers, female, aged 25-35, with initial melanin content of facial skin between 300-400, were recruited. The melanin content was tested using the MX18 melanin tester from the German CK company and recorded as the initial melanin content.

[0105] Ten people were divided into a group and used the test samples prepared from the compositions with whitening and acne scar removal effects of the embodiments and comparative examples once a day in the morning and evening, 3 ml each time, and evenly applied the test samples on the face after washing with a disposable face towel and clean water.

[0106] Use it continuously for 15 days. On the morning of the 16th day, clean your face with a disposable face towel and clean water, and then use the MX18 melanin tester from German CK company to test the melanin content again. Record it as the melanin content after 15 days of whitening.

[0107] Sample to be tested: 5 g of the composition with whitening and acne scar removal effect of each embodiment and comparative example and 95 g of deionized water are mixed evenly to prepare the sample to be tested.

[0108] The experimental data of each group were averaged.

[0109] Experiment 2 The test was conducted with reference to the test methods for bactericidal performance, antibacterial performance and stability of products in Appendix C of GB / T 15979-2002 "Sanitary Standards for Disposable Sanitary Products". The test samples were prepared using the compositions with whitening and acne scar removal effects of the embodiments and comparative examples. The action time was 20 minutes, the test was repeated 10 times, the test temperature was 26.7°C, and the relative humidity was 69%.

[0110] Sample to be tested: 5 g of the composition with whitening and acne scar removal effect of each embodiment and comparative example and 95 g of deionized water are mixed evenly to prepare the sample to be tested.

[0111] Test strain: Propionibacterium acnes, ATCC 11827.

[0112] Experiment 3 The test samples prepared from the compositions with whitening and acne scar removal effects of the embodiments and comparative examples were subjected to anti-wrinkle and firming effect tests.

[0113] 1. Test Principle The biochemical method for anti-wrinkle and firming efficacy mainly characterizes the anti-wrinkle and firming efficacy by evaluating the inhibition rate of the active substance on elastase. Elastase is the most important enzyme in the matrix metalloproteinase family, which is mainly synthesized and secreted by fibroblasts and can degrade elastin in the skin, leading to skin aging.

[0114] 2. Instruments, Equipment and Reagents 2.1 Instruments and equipment: Analytical balance; Full wavelength multifunctional microplate reader.

[0115] 2.2 Reagents and consumables: Tris(hydroxymethyl)aminomethane (AR); Concentrated hydrochloric acid (GR); Elastase (30 U / mg); EGCG (epigallocatechin gallate); AAAPAN(AR).

[0116] 2.3 Test sample: 5g of the composition with whitening and acne scar removal effect of each embodiment and comparative example and 95g of deionized water are mixed evenly to prepare a test sample; Negative control: deionized water; Positive control: EGCG solution.

[0117] 3. Test method: Four groups, ABCD, were set up respectively, with 3 parallels in each group. Buffer solution, sample solution, enzyme solution and substrate were added to the 96-well plate in sequence, and the 96-well plate was placed in a low-temperature oscillating water tank at a certain temperature, and the oscillation mode was turned on. After the solution inside reacted completely, the absorbance value of each group was measured at a wavelength of 410nm.

[0118] 4. Calculation formula Where: A—is the absorbance of the reaction solution containing sample and enzyme; B—is the absorbance of the reaction solution containing sample and without enzyme; C—is the absorbance of the reaction solution containing enzyme but not sample; D—is the absorbance of the reaction solution without sample and enzyme.

[0119] The specific experimental data of Experiments 1-3 are shown in Table 1.

[0120] According to the data comparison of each embodiment and the comparative example in Table 1, after 15 days of use, the melanin content of each embodiment is lower than that of each comparative example. It can be seen that each embodiment has a more significant whitening effect and can achieve a rapid whitening effect.

[0121] The average antibacterial rate of Propionibacterium acnes in each embodiment is higher than that in each comparative example. It can be seen that each embodiment has a stronger antibacterial effect, can quickly sterilize, make acne recover faster, and can achieve the effect of rapid acne removal.

[0122] The elastase inhibition rate of each embodiment is significantly higher than that of each comparative example. It can be seen that each embodiment can better restore the elasticity of the skin, thereby better smoothing acne marks and achieving the effect of quickly removing acne marks.

[0123] Each comparative example uses an extract with whitening and antibacterial effects to replace the Centella asiatica extract, willow bark extract, Phellodendron chinense bark extract, Houttuynia cordata extract, and Rubus idaeus extract in the examples alone or in whole. Since the special compound system of Centella asiatica extract, willow bark extract, Phellodendron chinense bark extract, Houttuynia cordata extract, and Rubus idaeus extract is destroyed, the synergistic effect cannot be exerted, resulting in a certain decrease in the whitening and antibacterial effects, and a significant decrease in the effect of inhibiting elastase, making it difficult to achieve the effects of whitening, acne removal, and acne mark removal at the same time.

[0124] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A composition having the effect of whitening and removing acne marks, characterized in that: The composition includes the following components in parts by weight: Solvent 21.5-23.5 parts; 1.8-2.2 parts of penetration enhancer; Stabilizer 0.4-0.6 parts; Emulsifier 0.9-1.1 parts; Composite extract 56.6-63.4 parts; Skin conditioning agent 13.3-20.7 parts; The composite extract is a compound of Centella asiatica extract, Salix alba bark extract, Phellodendron amurense bark extract, Houttuynia cordata extract and Raspberry extract.

2. A composition having the effect of whitening and removing acne marks according to claim 1, characterized in that: The mass ratio of the Centella asiatica extract, the willow bark extract, the phellodendron chinense bark extract, the houttuynia cordata extract and the raspberry extract is 2.8-3.2:24-26:14-16:14-16:1.8-2.

2.

3. A composition having the effect of whitening and removing acne marks according to claim 1, characterized in that: The skin conditioning agent is a compound of mandelic acid, niacinamide, α-arbutin, betaine and raspberry ketone glucoside.

4. A composition having the effect of whitening and removing acne marks according to claim 3, characterized in that: The mass ratio of mandelic acid, nicotinamide, α-arbutin, betaine and raspberry ketone glucoside is 3.5-4.5:2.5-3.5:0.8-1.2:5.5-6.5:1-5.

5. The composition with the effect of whitening and removing acne marks according to claim 1, characterized in that: The solvent is a compound of deionized water and isoprene glycol.

6. A composition having the effect of whitening and removing acne marks according to claim 5, characterized in that: The mass ratio of the deionized water to isoprene glycol is 17-18:4.5-5.

5.

7. A composition having the effect of whitening and removing acne marks according to claim 1, characterized in that: The penetration enhancer is lauroyl azolam, the stabilizer is p-hydroxyacetophenone, and the emulsifier is decyl glucoside.

8. A method for preparing the composition having the effect of whitening and removing acne marks according to any one of claims 1 to 7, characterized in that: The solvent, the penetration enhancer, the stabilizer, the emulsifier, the compound extract and the skin conditioner are uniformly mixed to obtain a composition with the effect of whitening and removing acne marks.

9. An application of the composition having the effect of whitening and removing acne scars according to any one of claims 1 to 7, characterized in that: The composition with the effect of whitening and removing acne marks is added to cosmetics for preparing the cosmetics with the effect of whitening and removing acne marks, and the mass content of the composition with the effect of whitening and removing acne marks in the cosmetics is 1-5%.

Citation Information

Patent Citations

  • Acne-removing cosmetic composite

    CN101766558A

  • Acne removal composition, essence containing acne removal composition and preparation method of essence

    CN118001200A

  • Composition with whitening and freckle removing effects and application thereof

    CN118021683A

  • SKIN FUNCTION-IMPROVING AGENT CONTAINING gamma-AMINOBUTYRIC ACID AND SPHINGOLIPID

    JP2008050297A

  • Cosmetic composition with excellent contribution to improvement

    KR102165559B1