Preparation method and application of spontaneous heating product capable of activating meridians to stop pain

Abstract

The invention belongs to the field of traditional Chinese medicine pain-relieving patches, and particularly discloses a preparation method and application of a spontaneous heating product capable of activating meridians to stop pain. According to the method, various Chinese herbal medicines including erigeron breviscapus and the like are used as raw materials, extract capable of dredging collaterals and relieving pain is prepared through extraction and concentration processes, and then the extract is diluted and soaked in non-woven fabric to prepare a medicinal paper layer. Meanwhile, heating materials such as iron powder and activated carbon are wrapped with film-coated non-woven fabric to form the heating layer, and the heating layer, the medicinal paper layer and the anti-sticking layer are fixed through hot press molding to obtain a self-heating product. In addition, non-steroidal anti-inflammatory drugs such as ibuprofen can be added into the extract capable of dredging collaterals and relieving pain, so that the pain relieving effect is enhanced. In the preparation process, various process parameters, such as extraction temperature and concentration pressure, need to be strictly controlled so as to ensure the product quality. After the product is prepared, the product needs to be placed in a sealing bag to be packaged in an air isolation mode so as to keep the self-heating effect and the medicine effect, and the product has the effects of activating meridians to stop pain and warming and relieving and is suitable for relieving pain and discomfort caused by rheumatism, arthritis and the like.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine analgesic patches, and specifically discloses a preparation method and application of a meridian-clearing analgesic self-heating product. Background Art

[0002] In modern society, with the accelerated pace of life and increased work pressure, more and more people are facing problems such as physical fatigue, muscle tension and joint pain. In order to relieve these symptoms, a variety of pain-relieving products have appeared on the market, including plasters, hot packs, self-heating products, etc. However, although these products can provide some relief to a certain extent, they still have many shortcomings in terms of effect and user experience.

[0003] Most of the self-heating products for dredging meridians and relieving pain on the market are prepared using traditional Chinese herbal medicine formulas. These products extract the active ingredients of Chinese herbal medicines, then apply them on heating materials, and use the oxidation reaction of the heating materials to generate heat, so that the active ingredients of the Chinese herbal medicines can penetrate into the skin and achieve the effect of dredging meridians and relieving pain. However, these products often lack innovation and optimization in their formulas, resulting in unsatisfactory product effects. Although some products can generate a certain amount of heat, the content of active ingredients in Chinese herbal medicines is low and the permeability is poor, which limits the therapeutic effect of the products.

[0004] In addition, existing self-heating products also have the problem of insufficient heating time. Many products have a short heating time and cannot meet the long-term needs of users. In order to extend the heating time, some products have to increase the amount of heating materials, but this will lead to an increase in product costs and may produce excessively high temperatures, causing discomfort to the skin.

[0005] In the selection of Chinese medicinal materials, although some traditional Chinese herbal medicines such as wolfberry, aralia, and chicken root have the effect of dredging meridians and relieving pain, their single use often has limited effect. As a Chinese medicinal material with significant medicinal value, Erigeron breviscapus contains a variety of active ingredients and has the effects of promoting blood circulation, removing blood stasis, dredging meridians and relieving pain. However, in the existing products for dredging meridians and relieving pain, Erigeron breviscapus is not widely used. This is mainly because the extraction and purification of the active ingredients of Erigeron breviscapus is difficult, and its compatibility with traditional Chinese herbal medicines also needs further research and optimization.

[0006] In addition, as a commonly used antipyretic and analgesic drug, non-steroidal anti-inflammatory drugs have significant anti-inflammatory and analgesic effects. However, existing analgesic products rarely use non-steroidal anti-inflammatory drugs in combination with Chinese herbal medicines. This is mainly because the pharmacological effects of non-steroidal anti-inflammatory drugs and the complex components of Chinese herbal medicines may interact with each other, and their safety and effectiveness also need to be further verified.

[0007] In terms of the design of the heating layer, most existing self-heating products use a single layer of heating material, which results in insufficient heating time and temperature control. Although some products try to use multiple layers of heating materials to extend the heating time, the multi-layer structure often increases the thickness and weight of the product, reducing the user's comfort.

[0008] In summary, the existing self-heating products for dredging collaterals and relieving pain have many deficiencies in formula, selection of Chinese medicinal materials, drug combination and heating layer design, resulting in unsatisfactory therapeutic effects and user experience of the products. Therefore, it is necessary to develop a new type of self-heating product for dredging collaterals and relieving pain to overcome the defects of the existing technology. Summary of the invention

[0009] In order to solve the above problems, the present invention discloses a preparation method and application of a meridian-clearing and analgesic self-heating product.

[0010] The technical solution of the present invention is as follows:

[0011] A method for preparing a spontaneously heating product for dredging meridians and relieving pain, comprising the following steps:

[0012] Step 1: preparing the analgesic extract for dredging collaterals: using wolfberry, aralia, chicken root, small red ginseng, tuckahoe, chrysanthemum, horsetail and erigeron asarum as active raw materials, and preparing the analgesic extract for dredging collaterals through extraction and concentration process;

[0013] Step 2: Make the medicine paper layer: dilute the Tongluo Zhitong extract to a multiple that is conducive to absorption and uniform distribution, soak the non-woven fabric in the extract, allow the extract to penetrate into the inside of the non-woven fabric, and then put it into the drying tunnel for drying;

[0014] Step 3: Assemble the product: stack the medicine paper layer, heating layer and anti-sticking layer in sequence, and fix them by hot pressing to obtain a self-heating product;

[0015] The analgesic extract is made from the following raw materials in parts by weight:

[0016]

[0017] The heating layer is composed of a non-woven composite breathable film wrapping the contents of iron powder, activated carbon, salt, water, and water-absorbent resin.

[0018] Furthermore, in the preparation method of the above-mentioned self-heating product for promoting blood circulation and relieving pain, the preparation process of the non-woven composite breathable membrane includes: using PE and Ca2CO3 as raw materials, mixing them, then forming a film and stretching them to form a breathable non-woven fabric.

[0019] Furthermore, in the preparation method of the above-mentioned self-heating product for promoting blood circulation and relieving pain, the particle size range of the Ca2CO3 is 3-4μm.

[0020] Furthermore, the preparation method of the above-mentioned Tongluo Zhitong Healing Product is that the Tongluo Zhitong Extract is prepared by the following process flow:

[0021] S1 Extraction

[0022] S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank;

[0023] S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃;

[0024] S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0025] S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃;

[0026] S15 After each water extraction, filter the liquid medicine and discard the medicine residue;

[0027] S2 Merge Concentration

[0028] S21 combines the three extracted medicinal solutions and performs reduced pressure concentration;

[0029] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0030] S23 is concentrated to a density of 1.15-1.25 g / mL, 80±5°C;

[0031] S3 mixed cream

[0032] S31 Add the extract of Erigeron breviscapus to the concentrated solution and mix well;

[0033] S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃;

[0034] S33 was concentrated to a density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

[0035] Furthermore, the preparation method of the above-mentioned product for promoting blood circulation and relieving pain and generating heat spontaneously, the preparation method of the extract of Erigeron breviscapus comprises the following steps:

[0036] 1) Pretreatment: Select fresh, pest-free, and mildew-free Erigeron breviscapus medicinal materials as raw materials, wash the medicinal materials, remove dirt, impurities, and dust on the surface, and then crush them through a 50-100 mesh sieve to obtain Erigeron breviscapus powder;

[0037] 2) Supercritical extraction: adding the powder of Erigeron breviscapus to a carbon dioxide supercritical extraction device for extraction; the entrainer is an ethanol aqueous solution with a concentration of 95% by volume;

[0038] The extraction temperature is 48°C to 52°C, the temperature of the first separator is 35°C, and the temperature of the second separator is 25°C; the pressure of the extractor is 13MPa to 17MPa, the pressure of the first separator is 8MPa, and the pressure of the second separator is 5MPa; the timing starts when the temperature and pressure of the extractor, the first separator, and the second separator reach the set value, and the extraction time is 100 minutes to 120 minutes; and an extract is obtained;

[0039] 3) Enzymolysis: the extract is added into the enzymolysis solution at a volume ratio of 1:9 for enzymolysis at a temperature of 30-40°C, and ultrasonic wave is used to promote enzymolysis; the enzymolysis solution contains 200-300 U / mL of cellulase, 100-200 U / mL of pectinase and 50-100 U / mL of neutral protease, and the balance is water; after enzymolysis for 12-36 hours, the enzymolysis solution is filtered and collected;

[0040] 4) Low temperature concentration: Low temperature concentration of the enzymatic hydrolysate to a phase density ≥ 1.30 g / mL to obtain the Erigeron breviscapus extract.

[0041] Furthermore, in the method for preparing the above-mentioned self-heating product for promoting blood circulation and relieving pain, after the self-heating product is prepared, it is placed in a sealed bag and packaged to isolate the air.

[0042] Furthermore, in the preparation method of the above-mentioned self-heating product for dredging meridians and relieving pain, the dredging meridians and relieving pain extract also contains non-steroidal anti-inflammatory drugs.

[0043] Furthermore, in the preparation method of the above-mentioned Tongluo Zhitong Self-heating Product, the Tongluo Zhitong Extract is made of the following raw materials in parts by weight:

[0044]

[0045] Furthermore, the preparation method of the above-mentioned Tongluo Zhitong Healing Product is that the Tongluo Zhitong Extract is prepared by the following process flow:

[0046] S1 Extraction

[0047] S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank;

[0048] S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃;

[0049] S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0050] S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃;

[0051] S15 After each water extraction, filter the liquid medicine and discard the medicine residue;

[0052] S2 Merge Concentration

[0053] S21 combines the three extracted medicinal solutions and performs reduced pressure concentration;

[0054] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0055] S23 is concentrated to a relative density of 1.15-1.25 g / mL, 80±5°C;

[0056] S3 mixed cream

[0057] S31 Adding Erigeron breviscapus extract and ibuprofen to the concentrate and mixing well;

[0058] S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃;

[0059] S33 was concentrated to a relative density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

[0060] The invention also discloses a meridian-dredging and pain-relieving self-heating product, which is prepared by any of the methods described above.

[0061] The present invention also discloses the use of a meridian-dredging and analgesic self-heating product in the preparation of a meridian-dredging and analgesic hot compress patch. The meridian-dredging and analgesic self-heating product is prepared by the above method.

[0062] Compared with the prior art, the innovation of the present invention is:

[0063] Addition of Erigeron breviscapus: This invention adds Erigeron breviscapus as one of the active raw materials to the self-heating product for the first time. By extracting the effective ingredients of Erigeron breviscapus and combining it with other Chinese herbal medicines, a blood circulation and pain-relieving extract is prepared; at the same time, we combine the blood circulation and pain-relieving extract with a heating layer that can generate steam and generate heat evenly to form a self-heating product. The steam allows the active drugs in the medicine paper layer to seep out better, resulting in better therapeutic effects; at the same time, the addition of Erigeron breviscapus significantly improves the blood circulation and pain-relieving effect of the product, allowing the product to better relieve the user's pain and discomfort.

[0064] Furthermore, in some embodiments, the present invention also combines Erigeron breviscapus with non-steroidal anti-inflammatory drugs for the first time. Through reasonable proportions and preparation processes, the two can work synergistically to further enhance the anti-inflammatory and analgesic effects of the product. This combination not only improves the therapeutic effect of the product, but also reduces the side effects that may be caused by a single drug.

[0065] In summary, the self-heating product for dredging meridians and relieving pain has made innovations in formula, selection of Chinese medicinal materials, preparation and selection of the heating layer, and combination of drugs, which significantly improves the therapeutic effect and user experience of the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0066] Figure 1 Comparison chart of the number of cured cases of Examples 1-6 and Comparative Examples 1-3 and the control example;

[0067] Figure 2 Comparison chart of the number of effective cases of Examples 1-6 and Comparative Examples 1-3 and Control Example;

[0068] Figure 3 Comparison chart of the effective number of examples 1-6 and comparative examples 1-3 and control examples;

[0069] Figure 4 Comparison chart of the effectiveness % of Examples 1-6 and Comparative Examples 1-3 and the control example. DETAILED DESCRIPTION

[0070] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0071] Example 1

[0072] A method for preparing a spontaneously heating product for dredging meridians and relieving pain, comprising the following steps:

[0073] Step 1: preparing the analgesic extract for dredging collaterals: using wolfberry, aralia, chicken root, small red ginseng, tuckahoe, chrysanthemum, horsetail and erigeron asarum as active raw materials, and preparing the analgesic extract for dredging collaterals through extraction and concentration process;

[0074] Step 2: Make the medicine paper layer: dilute the Tongluo Zhitong extract with ultrapure water by 5 times, soak the non-woven fabric in the extract, make the extract penetrate into the inside of the non-woven fabric, and then put it into the drying tunnel for drying;

[0075] Step 3: Assemble the product: stack the medicine paper layer, heating layer and anti-sticking layer in sequence, fix them by hot pressing to obtain a self-heating product.

[0076] The analgesic extract is made from the following raw materials in parts by weight:

[0077]

[0078] The Tongluo Zhitong extract is prepared by the following process:

[0079] S1 Extraction

[0080] S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank;

[0081] S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃;

[0082] S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0083] S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃;

[0084] S15 After each water extraction, filter the liquid medicine and discard the medicine residue;

[0085] S2 Merge Concentration

[0086] S21 combines the three extracted medicinal solutions and performs reduced pressure concentration;

[0087] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0088] S23 is concentrated to a density of 1.15-1.25 g / mL, 80±5°C;

[0089] S3 mixed cream

[0090] S31 Add the extract of Erigeron breviscapus to the concentrated solution and mix well; (Erigeron breviscapus extract was purchased from Shaanxi Snort Biotechnology Co., Ltd. with a specific gravity of 1.0-1.2)

[0091] S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃;

[0092] S33 was concentrated to a density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

[0093] The heating layer is composed of a non-woven composite breathable film wrapping the contents of iron powder, activated carbon, salt, water, and water-absorbent resin.

[0094] The preparation process of the non-woven composite breathable film includes: using PE and Ca2CO3 as raw materials, mixing them, forming a film and stretching them to form a breathable non-woven fabric, and the particle size of the Ca2CO3 is in the range of 3-4 μm.

[0095] After the product is prepared, it is placed in a sealed bag and packaged to isolate the air.

[0096] Example 2

[0097] A method for preparing a spontaneously heating product for dredging meridians and relieving pain, comprising the following steps:

[0098] Step 1: preparing the analgesic extract for dredging collaterals: using wolfberry, aralia, chicken root, small red ginseng, tuckahoe, chrysanthemum, horsetail and erigeron asarum as active raw materials, and preparing the analgesic extract for dredging collaterals through extraction and concentration process;

[0099] Step 2: Make the medicine paper layer: dilute the Tongluo Zhitong extract with ultrapure water by 5 times, soak the non-woven fabric in the extract, make the extract penetrate into the inside of the non-woven fabric, and then put it into the drying tunnel for drying;

[0100] Step 3: Assemble the product: stack the medicine paper layer, heating layer and anti-sticking layer in sequence, fix them by hot pressing to obtain a self-heating product.

[0101] The analgesic extract is made from the following raw materials in parts by weight:

[0102]

[0103] The Tongluo Zhitong extract is prepared by the following process:

[0104] S1 Extraction

[0105] S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank;

[0106] S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃;

[0107] S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0108] S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃;

[0109] S15 After each water extraction, filter the liquid medicine and discard the medicine residue;

[0110] S2 Merge Concentration

[0111] S21 combines the three extracted medicinal solutions and performs reduced pressure concentration;

[0112] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0113] S23 is concentrated to a density of 1.15-1.25 g / mL, 80±5°C;

[0114] S3 mixed cream

[0115] S31 Add the extract of Erigeron breviscapus to the concentrated solution and mix well; (Erigeron breviscapus extract was purchased from Shaanxi Snort Biotechnology Co., Ltd. with a specific gravity of 1.0-1.2)

[0116] S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃;

[0117] S33 was concentrated to a density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

[0118] The heating layer is composed of a non-woven composite breathable film wrapping the contents of iron powder, activated carbon, salt, water, and water-absorbent resin.

[0119] The preparation process of the non-woven composite breathable film includes: using PE and Ca2CO3 as raw materials, mixing them, forming a film and stretching them to form a breathable non-woven fabric, and the particle size of the Ca2CO3 is in the range of 3-4 μm.

[0120] After the product is prepared, it is placed in a sealed bag and packaged to isolate the air.

[0121] Example 3

[0122] A method for preparing a spontaneously heating product for dredging meridians and relieving pain, comprising the following steps:

[0123] Step 1: preparing the analgesic extract for dredging collaterals: using wolfberry, aralia, chicken root, small red ginseng, tuckahoe, chrysanthemum, horsetail and erigeron asarum as active raw materials, and preparing the analgesic extract for dredging collaterals through extraction and concentration process;

[0124] Step 2: Make the medicine paper layer: dilute the Tongluo Zhitong extract with ultrapure water by 5 times, soak the non-woven fabric in the extract, make the extract penetrate into the inside of the non-woven fabric, and then put it into the drying tunnel for drying;

[0125] Step 3: Assemble the product: stack the medicine paper layer, heating layer and anti-sticking layer in sequence, fix them by hot pressing to obtain a self-heating product.

[0126] The analgesic extract is made from the following raw materials in parts by weight:

[0127]

[0128] The Tongluo Zhitong extract is prepared by the following process:

[0129] S1 Extraction

[0130] S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank;

[0131] S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃;

[0132] S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0133] S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃;

[0134] S15 After each water extraction, filter the liquid medicine and discard the medicine residue;

[0135] S2 Merge Concentration

[0136] S21 combines the three extracted medicinal solutions and performs reduced pressure concentration;

[0137] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0138] S23 is concentrated to a density of 1.15-1.25 g / mL, 80±5°C;

[0139] S3 mixed cream

[0140] S31 Add the extract of Erigeron breviscapus to the concentrated solution and mix well; (Erigeron breviscapus extract was purchased from Shaanxi Snort Biotechnology Co., Ltd. with a specific gravity of 1.0-1.2)

[0141] S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃;

[0142] S33 was concentrated to a density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

[0143] The heating layer is composed of a non-woven composite breathable film wrapping the contents of iron powder, activated carbon, salt, water, and water-absorbent resin.

[0144] The preparation process of the non-woven composite breathable film includes: using PE and Ca2CO3 as raw materials, mixing them, forming a film and stretching them to form a breathable non-woven fabric, and the particle size of the Ca2CO3 is in the range of 3-4 μm.

[0145] After the product is prepared, it is placed in a sealed bag and packaged to isolate the air.

[0146] Example 4

[0147] Same as Example 2, but the extract of Erigeron breviscapus is prepared by itself, comprising the following steps:

[0148] 1) Pretreatment: Select fresh, pest-free, and mildew-free Erigeron breviscapus medicinal materials as raw materials, wash the medicinal materials, remove dirt, impurities, and dust on the surface, and then crush them through a 50-100 mesh sieve to obtain Erigeron breviscapus powder;

[0149] 2) Supercritical extraction: adding the powder of Erigeron breviscapus to a carbon dioxide supercritical extraction device for extraction; the entrainer is an ethanol aqueous solution with a concentration of 95% by volume;

[0150] The extraction temperature is 48°C to 52°C, the temperature of the first separator is 35°C, and the temperature of the second separator is 25°C; the pressure of the extractor is 13MPa to 17MPa, the pressure of the first separator is 8MPa, and the pressure of the second separator is 5MPa; the timing starts when the temperature and pressure of the extractor, the first separator, and the second separator reach the set value, and the extraction time is 100 minutes to 120 minutes; and an extract is obtained;

[0151] 3) Enzymolysis: the extract is added into the enzymolysis solution at a volume ratio of 1:9 for enzymolysis at a temperature of 30-40°C, and ultrasonic wave is used to promote enzymolysis; the enzymolysis solution contains 200-300 U / mL of cellulase, 100-200 U / mL of pectinase and 50-100 U / mL of neutral protease, and the balance is water; after enzymolysis for 12-36 hours, the enzymolysis solution is filtered and collected;

[0152] 4) Low temperature concentration: Low temperature concentration of the enzymatic hydrolysate to a phase density ≥ 1.30 g / mL to obtain the Erigeron breviscapus extract.

[0153] Example 5

[0154] Same as Example 2, but also containing 7.5 parts of ibuprofen.

[0155] Example 6

[0156] Same as Example 4, but also containing 7.5 parts of ibuprofen.

[0157] Comparative Example 1

[0158] A method for preparing a spontaneously heating product for dredging meridians and relieving pain, comprising the following steps:

[0159] Step 1: preparing the analgesic extract for dredging collaterals: using wolfberry, aralia, chicken root, small red ginseng, tuckahoe, chrysanthemum, horsetail and erigeron asarum as active raw materials, and preparing the analgesic extract for dredging collaterals through extraction and concentration process;

[0160] Step 2: Make the medicine paper layer: dilute the Tongluo Zhitong extract with ultrapure water by 5 times, soak the non-woven fabric in the extract, make the extract penetrate into the inside of the non-woven fabric, and then put it into the drying tunnel for drying;

[0161] Step 3: Assemble the product: stack the medicine paper layer, heating layer and anti-sticking layer in sequence, fix them by hot pressing to obtain a self-heating product.

[0162] The analgesic extract is made from the following raw materials in parts by weight:

[0163]

[0164] The Tongluo Zhitong extract is prepared by the following process:

[0165] S1 Extraction

[0166] S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank;

[0167] S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃;

[0168] S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C;

[0169] S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃;

[0170] S15 After each water extraction, filter the liquid medicine and discard the medicine residue;

[0171] S2 Merge Concentration

[0172] S21 combines the three extracted medicinal solutions and performs reduced pressure concentration;

[0173] The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃;

[0174] S23 was concentrated to a density of 1.15-1.25 g / mL at 80±5°C to obtain a Tongluo Zhitong extract.

[0175] The heating layer is composed of a coated non-woven fabric wrapping the contents of iron powder, activated carbon, salt, water, vermiculite and water-absorbent resin.

[0176] After the product is prepared, it is placed in a sealed bag and packaged to isolate the air.

[0177] Compared with Example 2, this comparative example does not contain the extract of Erigeron breviscapus, and the rest is the same.

[0178] Comparative Example 2

[0179] Commercially available Aolangwei pain relief patch (far infrared).

[0180] Comparative Example 3

[0181] Compared with Example 2, this comparative example does not contain the extract of Erigeron breviscapus, but contains 7.5 parts of ibuprofen; the rest are the same.

[0182] Comparative Example 4

[0183] Compared with Example 2, the heating layer in this comparative example is a common heating layer of a hot pack, contains vermiculite, and does not contain water and water-absorbing resin; the rest are the same.

[0184] Test Case

[0185] The self-heating products for dredging meridians and relieving pain of Examples 1-6 and Comparative Examples 1-4 were prepared into test specimens and tested.

[0186] In order to evaluate the specific effect of the self-heating product for dredging meridians and relieving pain, tests were conducted from aspects such as mouse writhing test, hot plate test and clinical cases. The experimental methods are as follows:

[0187] 1) Mouse writhing experiment: 220 mice, half male and half female, weighing 20g to 30g, were randomly divided into 11 groups according to gender and weight, with 20 mice in each group, and grouped into a blank control group (drug-free) and a drug-treated group (10 groups). 24h before the experiment, the mouse abdomen was shaved about 5cm*2cm, and the Tongluo analgesic self-heating products of Examples 1-6, Comparative Examples 1-4, and the control group were respectively taken, tied and fixed on the mouse abdomen, and the pain-relieving patch was changed twice a day, 12 hours each time, for 5 consecutive days. 60 minutes after the last change of the pain-relieving patch, 0.2 ml of acetic acid solution with a concentration of 0.6% was injected into the abdominal cavity of each mouse, and the number of writhing reactions of the mouse was recorded in the next 30 minutes. Statistical processing used single-factor analysis of variance of SPSS13.0 software (Windows version). The results are shown in Table 1.

[0188] 2) Hot plate experiment: Several mice were placed on a hot plate analgesic instrument at a temperature of 55-60°C. The time from the mouse's hind foot touching the hot plate to licking the hind foot was used as the pain threshold index. The pain threshold was measured on the hot plate analgesic instrument before the experiment. 200 mice with pain threshold values ​​within 10-30s were selected and randomly divided into a blank control group and a drug-treated group (10 groups). The normal pain threshold value was measured twice as the basal pain threshold value of the group before drug administration. 24h before the experiment, the mouse abdomen was shaved about 5cm*2cm, and the Tongluo analgesic self-heating products of Examples 1-6, Comparative Examples 1-4, and the control group were taken, tied and fixed on the mouse abdomen, and the pain-relieving patch was changed twice a day, each time for 12 hours, for 5 consecutive days. The pain threshold value of the mouse was measured 60min after the last administration, and the pain threshold values ​​of the mouse before and after administration were compared, and statistical analysis was performed. The experimental results were statistically processed using SPSS13.0for windows One-Way ANOVA. Statistical processing used one-way analysis of variance using SPSS13.0 software (Windows version). The results are shown in Table 1.

[0189] Table 1 Summary of analgesic effect test data.

[0190]

[0191]

[0192] In the data of Table 1, it can be seen from the comparison between Example 2 and Comparative Example 1 that the addition of Erigeron breviscapus significantly improves the analgesic effect of the product, so that the product can better relieve the pain and discomfort of mice; from the comparison between Example 2 and Example 4, it can be seen that the Erigeron breviscapus extract prepared by the method disclosed in the present invention has a better analgesic effect when added as an active substance compared to the commercially available ordinary Erigeron breviscapus extract; from the comparison between Example 2 and Example 4 and Comparative Examples 1-3, it can be seen that Erigeron breviscapus is used in combination with the non-steroidal anti-inflammatory drug ibuprofen, and through a reasonable ratio and preparation process, the two can work synergistically, further enhancing the anti-inflammatory and analgesic effects of the product. From the comparison between Example 2 and Comparative Example 4, it can be seen that by using the heating layer in Example 2, compared with the traditional heating layer, the active drug in the medicine paper layer is better exuded through steam, resulting in a better therapeutic effect.

[0193] 3) Volunteer trials

[0194] 1. Grouping:

[0195] The self-heating products prepared in Examples 1 to 6 and Comparative Examples 1 to 4 were used to conduct group volunteer experiments on patients diagnosed with rheumatoid arthritis by traditional Chinese medicine. 220 cases, including 148 males and 72 females, aged between 50 and 75 years old, were randomly divided into 11 groups, including a blank control group (without drug).

[0196] 2. Criteria for determining efficacy

[0197] Cure: All symptoms and signs are eliminated, and functional activities return to normal;

[0198] Markedly effective: All symptoms are eliminated or major symptoms are eliminated, and functional activities are basically normal;

[0199] Effective: The main symptoms are basically eliminated, and the functions of the main joints are basically restored or significantly improved;

[0200] Ineffective: There is basically no improvement compared with before treatment.

[0201] 3. Treatment methods

[0202] Select acupoints according to the location of pain, and stick the self-heating product on the underwear at the corresponding location. Apply once a day, 15 consecutive times as a course of treatment, and a total of 2 courses of treatment.

[0203] 4. Treatment effect

[0204] After 2 courses of treatment, the clinical observation of the treatment effect is shown in Table 2 and Figure 1-4 shown.

[0205] Table 2 Clinical treatment effect statistics

[0206]

[0207]

[0208] Among them, effective rate = (number of cured cases + number of significantly effective cases + number of effective cases) / number of cases in a single group.

[0209] In the clinical data of Table 2, it can be seen from the comparison between Example 2 and Comparative Example 1 that, similar to the animal experiment, the addition of Erigeron breviscapus significantly improves the analgesic effect of the product, so that the product can better relieve the pain and discomfort of patients;

[0210] Similar to the animal experiment, it can be seen from the comparison between Example 2 and Example 4 that the Erigeron breviscapus extract prepared by the method disclosed in the present invention has a better analgesic effect when added as an active substance compared to the common Erigeron breviscapus extract available on the market;

[0211] Similar to the animal experiments, it can be seen from the comparison between Example 2 and Comparative Example 4 that, compared with the traditional heating layer, the steam allows the active drugs in the medicine paper layer to seep out better, resulting in better therapeutic effects.

[0212] Further, from the comparison between Example 2 and Example 4 and Comparative Examples 1-3, it can be seen that the combination of Radix Eryngii and the non-steroidal anti-inflammatory drug ibuprofen, through a reasonable ratio and preparation process, enables the two to act synergistically to further enhance the anti-inflammatory and analgesic effects of the product. This combination not only improves the therapeutic effect of the product, but also reduces the side effects that may be caused by a single drug.

[0213] The above are only a few preferred embodiments of the present invention, and the description is relatively specific and detailed, but it cannot be understood as limiting the scope of the present invention. It should be pointed out that for ordinary technicians in this field, several modifications and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A method for preparing a spontaneously heated product for dredging meridians and relieving pain, characterized in that: The following steps are involved: Step 1: preparing the analgesic extract for dredging collaterals: using wolfberry, aralia, chicken root, small red ginseng, tuckahoe, chrysanthemum, horsetail and erigeron asarum as active raw materials, and preparing the analgesic extract for dredging collaterals through extraction and concentration process; Step 2: Make the medicine paper layer: dilute the Tongluo Zhitong extract to a multiple that is conducive to absorption and uniform distribution, soak the non-woven fabric in the extract, allow the extract to penetrate into the inside of the non-woven fabric, and then put it into the drying tunnel for drying; Step 3: Assemble the product: stack the medicine paper layer, heating layer and anti-sticking layer in sequence, and fix them by hot pressing to obtain a self-heating product; The analgesic extract is made from the following raw materials in parts by weight: The heating layer is composed of a non-woven composite breathable film wrapping the contents of iron powder, activated carbon, salt, water, and water-absorbent resin.

2. The method for preparing a spontaneously heating product for dredging meridians and relieving pain according to claim 1, characterized in that: The preparation process of the non-woven composite breathable film comprises: taking PE and Ca2CO3 as raw materials, mixing them evenly, then forming a film and stretching them to form a breathable non-woven fabric.

3. The method for preparing a spontaneously heating product for dredging meridians and relieving pain according to claim 1, characterized in that: The particle size of the Ca2CO3 is in the range of 3-4 μm.

4. The method for preparing a spontaneously heating product for dredging meridians and relieving pain according to claim 1, characterized in that: The Tongluo Zhitong extract is prepared by the following process: S1 Extraction S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank; S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃; S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C; S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃; S15 After each water extraction, filter the liquid medicine and discard the medicine residue; S2 Merge Concentration S21 combines the three extracted medicinal solutions and performs reduced pressure concentration; The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃; S23 is concentrated to a density of 1.15-1.25 g / mL, 80±5°C; S3 mixed cream S31 Add the extract of Erigeron breviscapus to the concentrated solution and mix well; S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃; S33 was concentrated to a density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

5. The preparation method according to claim 1, characterized in that: The preparation method of the Erigeron Breviscapus extract comprises the following steps: 1) Pretreatment: Select fresh, pest-free, and mildew-free Erigeron breviscapus medicinal materials as raw materials, wash the medicinal materials, remove the dirt, impurities and dust on the surface, and then crush them through a 50-100 mesh sieve to obtain Erigeron breviscapus powder; 2) Supercritical extraction: adding the powder of Erigeron breviscapus to a carbon dioxide supercritical extraction device for extraction; the entrainer is an ethanol aqueous solution with a concentration of 95% by volume; The extraction temperature is 48°C to 52°C, the temperature of the first separator is 35°C, and the temperature of the second separator is 25°C; the pressure of the extractor is 13MPa to 17MPa, the pressure of the first separator is 8MPa, and the pressure of the second separator is 5MPa; the timing starts when the temperature and pressure of the extractor, the first separator, and the second separator reach the set value, and the extraction time is 100 minutes to 120 minutes; and an extract is obtained; 3) Enzymolysis: the extract is added into the enzymolysis solution at a volume ratio of 1:9 for enzymolysis at a temperature of 30-40°C, and ultrasonic wave is used to promote enzymolysis; the enzymolysis solution contains 200-300 U / mL of cellulase, 100-200 U / mL of pectinase and 50-100 U / mL of neutral protease, and the balance is water; after enzymolysis for 12-36 hours, the enzymolysis solution is filtered and collected; 4) Low temperature concentration: Low temperature concentration of the enzymatic hydrolysate to a phase density ≥ 1.30 g / mL to obtain the Erigeron breviscapus extract.

6. The method for preparing a spontaneously heating product for dredging meridians and relieving pain according to claim 1, characterized in that: After the product is prepared, it is placed in a sealed bag and packaged to isolate the air.

7. The method for preparing a spontaneously heating product for dredging meridians and relieving pain according to claim 1, characterized in that: The collateral-clearing and pain-relieving extract also contains nonsteroidal anti-inflammatory drugs.

8. The method for preparing a spontaneously heating product for dredging meridians and relieving pain according to claim 7, characterized in that: The analgesic extract is made from the following raw materials in parts by weight:

9. The method for preparing a spontaneously heating product for dredging meridians and relieving pain according to claim 7, characterized in that: The Tongluo Zhitong extract is prepared by the following process: S1 Extraction S11: Put wolfberry, aralia, chicken root, small red ginseng, poria, chrysanthemum and horsetail slices into an extraction tank; S12 first water extraction: add 8 times the mass of drinking water, boil for 1.5 hours, and control the temperature at 85-95℃; S13 Second water extraction: add 8 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95°C; S14 The third water extraction: add 6 times the mass of drinking water to the residue, boil for 1.5 hours, and control the temperature at 85-95℃; S15 After each water extraction, filter the liquid medicine and discard the medicine residue; S2 Merge Concentration S21 combines the three extracted medicinal solutions and performs reduced pressure concentration; The pressure of S22 concentration equipment is controlled at -0.01~0.07MPa and the temperature is controlled at 55~85℃; S23 is concentrated to a relative density of 1.15-1.25 g / mL, 80±5°C; S3 mixed cream S31 Adding Erigeron breviscapus extract and ibuprofen to the concentrate and mixing well; S32 is again subjected to reduced pressure concentration, the equipment pressure is controlled at -0.01~0.07MPa, and the temperature is controlled at 50~88℃; S33 was concentrated to a relative density ≥1.30 g / mL, 83±5°C to obtain a Tongluo Zhitong extract.

10. Application of a self-heating product for dredging meridians and relieving pain in the preparation of a dredging meridians and relieving pain hot compress, characterized in that: The self-heating product for dredging meridians and relieving pain is prepared by the method described in any one of claims 1 to 9.

Images