Device for preparing platelet-rich plasma suspension containing blood cells and gel of platelet-rich plasma suspension

Abstract

The invention discloses a platelet-rich plasma suspension containing blood cells and a preparation device of gel of the platelet-rich plasma suspension. Comprising a fixing frame, at least one rapid clamping pipe clamp installed on the fixing frame, a vacuum centrifugal pipe clamped in the rapid clamping pipe clamp, and two suction devices capable of being inserted into the centrifugal pipe from the top or the bottom of the centrifugal pipe. The pusher is used for pushing the aspirator to be inserted into the centrifugal tube; the rotating mechanism is used for driving the pusher to rotate so as to enable the aspirator to face the top or the bottom of the centrifugal tube; the problems that in the prior art, blood pollution is likely to be caused in the manual operation process, manual operation errors exist, and the extraction rate is low are solved, all blood platelets and white blood cells in blood are reserved, and normal-proportion red blood cells and most plasma protein are reserved; moreover, the concentration of platelets and leukocytes is constantly about 4 times of the concentration of blood of common normal people, the functions of erythrocyte components are reserved, and the functional effects of various components in the blood can be better exerted.

Description

Technical Field

[0001] The invention relates to the technical field of medical devices, in particular to a device for preparing a blood cell platelet-rich plasma suspension and a gel thereof. Background Art

[0002] Platelet-rich plasma is concentrated in plasma by separating platelets from blood through density gradient centrifugation according to the different sedimentation coefficients of the components in the blood, and then directly injecting it into the lesion site to produce a therapeutic effect. At present, there are two methods for preparing PRP: one is to artificially absorb platelets and part of the plasma after centrifuging the blood to separate the blood, and then mix the two to form concentrated platelet plasma. Another method is to add blood to a centrifuge tube containing a separation gel and centrifuge it again, separate the platelet plasma layer and the red blood cells, and then absorb and discard part of the upper plasma to obtain a mixture of lower plasma and platelets. Regardless of the method, the PRP prepared at present is a final product with concentrated platelet concentration and discarded red blood cells and / or white blood cell components. However, there are problems such as low platelet extraction rate, uncontrollable concentration, poor homogeneity, and waste of platelet, red blood cell and / or white blood cell functional components. Summary of the invention

[0003] The main purpose of the present invention is to solve the above-mentioned problems and provide a device for preparing a blood cell platelet-rich plasma suspension and a gel thereof.

[0004] The technical solution of the present invention is:

[0005] A device for preparing a blood cell platelet-rich plasma suspension and a gel thereof, comprising a fixing frame, at least one quick-clamp tube clamp mounted on the fixing frame, a vacuum centrifuge tube clamped in the quick-clamp tube clamp, two aspirators that can be inserted into the centrifuge tube from the top or bottom, a pusher for pushing the aspirators into the centrifuge tube, and a rotating mechanism for driving the pusher to rotate so that the aspirator faces the top or bottom of the centrifuge tube. The aspirator is mounted on the pusher so that the pusher can move the aspirator toward the centrifuge tube and the rotating mechanism can drive the pusher to rotate from the top of the centrifuge tube to the bottom of the centrifuge tube.

[0006] The vacuum centrifuge tube comprises a tube body and a cover body screwed on both ends of the tube body respectively, and the cover body comprises a threaded sleeve and a rubber plug arranged inside the threaded sleeve.

[0007] The rotating mechanism includes a base frame, two hollow rings rotatably mounted on the base frame via rollers, a gear ring fixed to one of the hollow rings, two connecting plates symmetrically connected between the two hollow rings, a driving gear meshing with the gear ring, and a rotating motor whose motor shaft is fixed to the driving gear.

[0008] The pusher includes a pushing cylinder, a movable plate and four guide pillars. The movable plate is inserted into the hollow positions of the two hollow rings. The pushing cylinder is installed on the connecting plate and its lifting head rod is connected to the movable plate. The four guide pillars are fixed on the movable plate and pass through the connecting plate.

[0009] The aspirator is fixed on the movable plate, the aspirator is fixed on the movable plate, the aspirator includes an electric lifting body and a disposable syringe, the electric lifting body includes a guide tube body, a lifting head filled in the guide tube body, a screw fixed to the lifting head, a threaded tube with one end threadedly connected to the screw, a lifting motor fixed to the motor shaft and the other end of the threaded tube, and a receiving plate for fixing the guide tube body and the lifting motor, the guide tube body is provided with a clamping ring for fixing the syringe barrel of the disposable syringe, and the lifting head is provided with a clamping groove for the top of the core rod of the disposable syringe to be clamped.

[0010] The end of the guide tube body is provided with an inserting portion for inserting the disposable syringe.

[0011] The suction device is installed on the movable plate through an electric slide, and the movable plate is installed on a slider of the electric slide.

[0012] The beneficial effects of the present invention are as follows: the present invention solves the problems of blood contamination, human operation errors and low extraction rate easily caused during manual operation in the prior art, retains all platelets and white blood cells in the blood (extraction rate is close to 100%), retains a normal proportion of red blood cells and most plasma proteins, and the concentration of platelets and white blood cells is constant at about 4 times the concentration in the blood of ordinary normal people, retains the function of red blood cell components, and can better exert the functional effects of various components in the blood. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a stereogram of the present invention.

[0014] Figure 2 It is the front view of the present invention.

[0015] Figure 3 It is a schematic diagram of a centrifuge tube of the present invention.

[0016] Figure 4 for Figure 3 Schematic diagram of the cross section of AA.

[0017] Figure 5 It is a schematic diagram of the cross-sectional structure of the aspirator of the present invention. DETAILED DESCRIPTION

[0018] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. Preferred embodiments of the present invention are provided in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0019] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0020] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0021] Please refer to Figures 1 to 5, is a preferred embodiment of the present invention, a device for preparing a blood cell platelet-rich plasma suspension and a gel thereof, comprising a fixing frame 10, at least one quick-clamping tube clamp 20 installed on the fixing frame 10, a vacuum centrifuge tube 30 clamped in the quick-clamping tube clamp 20, two aspirators 40 that can be inserted into the centrifuge tube 30 from the top or bottom thereof, a pusher 50 for pushing the aspirator 40 to be inserted into the centrifuge tube 30, and a rotating mechanism 60 for driving the pusher 50 to rotate so that the aspirator 40 faces the top or bottom of the centrifuge tube 30, the aspirator 40 is installed on the pusher 50, so that the pusher 50 can move the aspirator 40 toward the centrifuge tube 30, and the rotating mechanism 60 can drive the pusher 50 to rotate from the top of the centrifuge tube 30 to the bottom of the vacuum centrifuge tube 30. In specific use, the vacuum centrifuge tube 30 is used to hold fresh blood and can be placed in a medical centrifuge for centrifugal operation. Specifically, the fresh blood drawn is loaded into the vacuum centrifuge tube 30, and then the centrifuge tube 30 is placed in a medical centrifuge for centrifugal operation. The centrifugal speed is 3600 rpm, and the centrifugal time is 10 minutes. The obtained blood is divided into three layers (the upper layer is plasma, the middle layer is platelets and white blood cells, and the lower layer is red blood cells). Then, the centrifuge tube 30 is placed in the quick-clamp tube clamp 20, and the centrifuge tube 30 is clamped by the quick-clamp tube clamp 20. The centrifuge tube 30 is kept in an upright position without After shaking, an aspirator is inserted from the top of the centrifuge tube 30 through the pusher 50 and 8 / 11 of the upper plasma is first extracted, and then the pusher 50 and the aspirator 40 are driven to rotate to the bottom of the centrifuge tube 10 through the rotating mechanism 60, and the same aspirator or another aspirator is pushed by the pusher 50 to be inserted from the bottom of the centrifuge tube and 2 / 3 of the red blood cells in the lower layer are extracted, and then the remaining blood component mixture (all platelets, all white blood cells, all plasma proteins and a small part of red blood cells) is obtained to obtain a new whole blood component product, called blood cell platelet-rich plasma suspension. Finally, other aspirators can be used to add coagulants or other drugs to the suspension to make it into blood cell platelet-rich plasma gel and other complexes.

[0022] In this embodiment, if Figure 2As shown, the rotating mechanism 60 includes a base frame 61, two hollow rings 62 rotatably mounted on the base frame 61 through rollers, a gear ring 63 fixed to one of the hollow rings 62, two connecting plates 64 symmetrically connected between the two hollow rings 62, a driving gear 65 meshing with the gear ring 63, and a rotating motor 66 whose motor shaft is fixed to the driving gear 65. When the rotating motor 66 is working, it drives the driving gear 65 to rotate, thereby driving the gear ring 63 to rotate, and the hollow ring 62 fixed thereto is driven to rotate through the gear ring 63. Since the two hollow rings 62 are connected together through the connecting plate 64, the other hollow ring 62 also rotates accordingly.

[0023] In this embodiment, if Figure 2 As shown, the pusher 50 includes a pushing cylinder 51, a movable plate 52 and four guide pillars 53. The movable plate 52 is inserted into the hollow position of the two hollow rings 62. The pushing cylinder 51 is installed on the connecting plate 64 and its lifting head rod is connected to the movable plate 52. The four guide pillars 53 are fixed on the movable plate 52 and pass through the connecting plate 64, so that the pushing cylinder 51 pushes the movable plate 52 to move.

[0024] In this embodiment, if Figure 5 As shown, the aspirator 40 is fixed on the movable plate 52, and the aspirator 40 includes an electric lifting body 41 and a disposable syringe 42. It is worth mentioning here that the disposable syringe 42 is a disposable medical sterile injector commonly found on the market.

[0025] The electric lifting body 41 includes a guide tube body 411, a lifting head 412 filled in the guide tube body 411, a screw 413 fixed to the lifting head 412, a threaded tube 414 with one end screwed to the screw 413, a lifting motor 415 with a motor shaft fixed to the other end of the threaded tube 414, and a receiving plate 416 for fixing the guide tube body 411 and the lifting motor 415. The guide tube body 411 is provided with a clamping ring 417 for fixing the syringe 421 of the disposable syringe 42, and the lifting head 412 is provided with a clamping groove 418 for the top of the core rod 422 of the disposable syringe to be clamped. When the lifting motor 415 is working, it drives the threaded tube 414 to rotate. Since the outer surface of the lifting head 412 is in close contact with the inside of the guide tube body 411, the screw 413 can be screwed into the inside of the threaded tube 414 to achieve the effect of driving the lifting head 412 to move on the inner wall of the guide tube body 411. When the top of the core rod 422 of the disposable syringe 42 is inserted into the slot 418, the core rod 422 can be moved by the movement of the lifting head 412. After the disposable syringe 42 extracts the relevant liquid (plasma, red blood cells), the disposable syringe 42 can be removed and discarded.

[0026] In this embodiment, in order to enable an arbitrarily selected aspirator to extract blood from the centrifuge tube, the aspirator 40 is installed on the movable plate 52 through an electric slide 70, and the movable plate 52 is installed on the slider of the electric slide 70 to achieve lateral movement of the aspirator 40 through the electric slide 70. It is worth mentioning that the electric slide 70 and the quick-clamping tube clamp 20 are accessories commonly used in the mechanical field, and their specific structures are not described here.

[0027] In this embodiment, if Figure 3 , Figure 4 As shown, the vacuum centrifuge tube 30 includes a tube body 31 and a cover body 32 screwed on both ends of the tube body 31, and the cover body 32 includes a threaded sleeve 321 and a rubber plug 322 arranged inside the threaded sleeve 321. The function of the rubber plug is to allow the needle of the aspirator to be inserted.

[0028] What the present invention aims to achieve is to solve the problems of blood contamination and human operation errors easily caused by manual operation in the prior art, retain all platelets and white blood cells in the blood (extraction rate is close to 100%), retain a normal proportion of red blood cells and most plasma proteins, and the concentration of platelets and white blood cells is constant at about 4 times the concentration in normal human blood, retaining the function of red blood cell components, and being able to better exert the functional effects of various components in the blood.

[0029] The above descriptions are merely embodiments of the present invention and are not intended to limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made using the contents of the present invention specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A device for preparing a blood cell platelet-rich plasma suspension and a gel thereof, characterized in that: The invention comprises a fixing frame, at least one quick-clamping tube clamp installed on the fixing frame, a vacuum centrifuge tube clamped in the quick-clamping tube clamp, two aspirators which can be inserted into the centrifuge tube from the top or bottom, a pusher for pushing the aspirator into the centrifuge tube, and a rotating mechanism for driving the pusher to rotate so that the aspirator faces the top or bottom of the centrifuge tube. The aspirator is installed on the pusher so that the pusher can move the aspirator toward the centrifuge tube and the rotating mechanism can drive the pusher to rotate from the top of the centrifuge tube to the bottom of the centrifuge tube.

2. The device for preparing a blood cell platelet-rich plasma suspension and a gel thereof as claimed in claim 1, characterized in that: The vacuum centrifuge tube comprises a tube body and a cover body screwed on both ends of the tube body respectively, and the cover body comprises a threaded sleeve and a rubber plug arranged inside the threaded sleeve.

3. The device for preparing a blood cell platelet-rich plasma suspension and a gel thereof as claimed in claim 2, characterized in that: The rotating mechanism includes a base frame, two hollow rings rotatably mounted on the base frame via rollers, a gear ring fixed to one of the hollow rings, two connecting plates symmetrically connected between the two hollow rings, a driving gear meshing with the gear ring, and a rotating motor whose motor shaft is fixed to the driving gear.

4. The device for preparing a blood cell platelet-rich plasma suspension and a gel thereof as claimed in claim 3, characterized in that: The pusher includes a pushing cylinder, a movable plate and four guide pillars. The movable plate is inserted into the hollow positions of the two hollow rings. The pushing cylinder is installed on the connecting plate and its lifting head rod is connected to the movable plate. The four guide pillars are fixed on the movable plate and pass through the connecting plate.

5. The device for preparing a blood cell platelet-rich plasma suspension and a gel thereof as claimed in claim 4, characterized in that: The aspirator is fixed on the movable plate, and includes an electric lifting body and a disposable syringe. The electric lifting body includes a guide tube body, a lifting head filled in the guide tube body, a screw fixed to the lifting head, a threaded tube with one end threadedly connected to the screw, a lifting motor fixed to a motor shaft and the other end of the threaded tube, and a receiving plate for fixing the guide tube body and the lifting motor. The guide tube body is provided with a clamping ring for fixing the syringe barrel of the disposable syringe, and the lifting head is provided with a clamping groove for the top of the core rod of the disposable syringe to be clamped into.

6. The device for preparing a blood cell platelet-rich plasma suspension and a gel thereof as claimed in claim 6, characterized in that: The suction device is installed on the movable plate through an electric slide, and the movable plate is installed on a slider of the electric slide.

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