Traditional Chinese medicine gel for treating ulcerative colitis and preparation method thereof

Abstract

The invention relates to the technical field of pharmaceutical compositions, in particular to traditional Chinese medicine gel for treating ulcerative colitis and a preparation method of the traditional Chinese medicine gel. The traditional Chinese medicine gel for treating ulcerative colitis is prepared from the following components in parts by mass: 4-8 parts of a traditional Chinese medicine extracting agent, 2-6 parts of a synergist, 2-4 parts of an adsorbent, 20-30 parts of a gel matrix, 0.10-0.15 part of a preservative and 60-80 parts of water. The traditional Chinese medicine gel provided by the invention has an obvious improvement effect on ulcerative colitis, and is superior to a medicine in the prior art. The traditional Chinese medicine gel is simple in preparation process and convenient to use, the components are pure traditional Chinese medicine preparations, toxic and side effects are avoided, and good clinical application prospects are achieved.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical compositions, and in particular to a traditional Chinese medicine gel for treating ulcerative colitis and a preparation method thereof. Background Art

[0002] Ulcerative colitis (UC) is a common gastrointestinal inflammatory disease with complex etiology and pathogenesis. The lesions are mostly located in the sigmoid colon and rectum, and can extend to the descending colon or the entire colon in severe cases. The main symptoms are abdominal pain, diarrhea, thick mucus, bloody stools, tenesmus, etc. The main site of disease is in the intestine, commonly in the sigmoid colon and rectum, with local distribution. The inflammatory sites are mainly the mucosa and submucosa. It is easy to relapse and has a long course, which has a huge impact on the patient's physical and mental health and economy. In recent years, with the increasing research on Chinese herbal medicine, the potential role of Chinese medicine in the treatment of gastrointestinal diseases has been generally recognized worldwide. During the course of UC patients' illness, damage to local colon tissues, external pathogenic factors, and the influence of their own factors will cause obvious abnormal reactions in their immunity, such as a large number of immune cells infiltrating the intestinal mucosa; fluctuations in proinflammatory factors such as IL-18, IL-2, IL-1β, IL-5, TNF-α, etc.; T, B lymphocytes, monocytes, and NK cells will also proliferate in large numbers. These antibodies, cytokines and inflammatory mediators released into the intestinal mucosal tissue trigger severe reactions around the intestine, directly destroying the intestinal mucosal epithelial tissue and causing long-term inflammatory lesions.

[0003] Since the lesions of ulcerative colitis are mainly in the colon, with the sigmoid colon being the most common, its pathological manifestation is that the intestinal mucosa is infiltrated by inflammatory cells such as neutrophils for a long time, leading to epithelial cell apoptosis, thereby causing damage to the intestinal mucosa and further causing bleeding and other phenomena. Therefore, accurate delivery of drugs to the lesion site, prolonging the retention time of the drugs, and repairing the ulcer surface are the keys to treatment. Clinically, suppositories or enemas are mainly used. Although the therapeutic effect is significant, patient compliance is not high. Conventional ordinary oral preparations lack the colon positioning characteristics and it is difficult to reach the lesion site intact. Even if they can reach the site, the amount of medicine left is very little, and it is difficult to achieve the therapeutic purpose.

[0004] In situ gel is a type of preparation that can undergo a phase transition immediately at the site of administration after being administered in a solution state, transforming from a liquid state to form a non-chemically cross-linked semi-solid gel. Gels have good tissue compatibility and a long retention time at the site of administration; they can also store drugs and protect them from environmental influences. According to the different formation mechanisms, in situ gels can be divided into temperature-sensitive, pH-sensitive, and ion-sensitive types. As a new type of drug dosage form, in situ gels are widely used in new drug delivery systems such as sustained release, controlled release, and pulsed release. They can be applied to multiple routes of administration such as skin, eyes, nasal cavity, oral cavity, vagina, and rectum, and have become a research hotspot in the fields of pharmacy and biotechnology.

[0005] Therefore, how to prepare a gel preparation that can be used to treat ulcerative colitis is a problem that needs to be solved urgently by those skilled in the art. Summary of the invention

[0006] The purpose of the present invention is to provide a traditional Chinese medicine gel for treating ulcerative colitis and a preparation method thereof.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] The present invention provides a Chinese medicine gel for treating ulcerative colitis, which is prepared from the following components by weight: 4 to 8 parts of a Chinese medicine extractant, 2 to 6 parts of a synergist, 2 to 4 parts of an adsorbent, 20 to 30 parts of a gel matrix, 0.10 to 0.15 parts of a preservative, and 60 to 80 parts of water;

[0009] The traditional Chinese medicine extract comprises the following components in parts by weight: 50-70 parts of coptis root, 20-40 parts of frankincense, 3-7 parts of sanguisorba officinalis, 3-7 parts of indigo naturalis, 50-70 parts of catechu, and 50-70 parts of dragon's blood.

[0010] Preferably, the synergist is eucalyptus oil, chitosan oligosaccharide and laurocapram, and the mass ratio is 8-12:7-11:16-20.

[0011] Preferably, the adsorbent is hyaluronic acid and sodium alginate in a mass ratio of 1-3:1-3.

[0012] Preferably, the gel matrix is: poloxamer 407, poloxamer 108 and poloxamer 237, with a mass ratio of 16-20:8-12:5-9.

[0013] Preferably, the preservative is benzalkonium bromide, sodium benzoate or potassium sorbate.

[0014] The present invention also provides a method for preparing the Chinese medicine gel for treating ulcerative colitis, comprising the following steps:

[0015] (1) mixing coptis root, frankincense, sanguisorba officinalis, indigo naturalis, catechu, and dragon's blood to obtain material 1; mixing material 1 with water and boiling, filtering to obtain a filtrate, concentrating the filtrate and drying to obtain a traditional Chinese medicine extract;

[0016] (2) mixing the Chinese medicine extract, synergist, adsorbent and water to obtain a drug solution;

[0017] (3) The drug solution, gel matrix and preservative are mixed and swollen to obtain a traditional Chinese medicine gel for treating ulcerative colitis.

[0018] Preferably, in step (1), the mass ratio of material 1 to water is 1:3-5; and the decoction time is 2-4 hours.

[0019] Preferably, the concentration in step (1) is: concentrating under reduced pressure to an extract having a relative density of 1.13 to 1.17 at 65°C.

[0020] Preferably, the drying temperature in step (1) is 72-78° C. and the drying time is 2-4 hours.

[0021] Preferably, the swelling temperature in step (3) is 5 to 7° C. and the swelling time is 20 to 26 hours.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] The Qingkuiyuyang prescription provided by the present invention includes: Rhizoma Coptidis clearing away heat and drying dampness, Olibanum removing blood stasis and protecting membranes, Radix Sanguisorbae astringing the intestines and stopping diarrhea, Indigo clearing away heat and cooling blood, Catechu astringing and relieving pain, and Radix Sanguisorbae astringent and healing ulcers. According to the compatibility analysis, the whole prescription clears away heat and drying dampness, activates blood circulation and removes blood stasis, astringes the intestines and heals ulcers. It is suitable for TCM diagnosis of dysentery (damp-heat syndrome of large intestine).

[0024] The present invention prepares a Chinese medicine prescription into a gel preparation for rectal administration. The Chinese medicine gel can undergo a phase transition at the physiological temperature of the rectum to form a semisolid gel, thereby achieving the purpose of local administration or sustained-release controlled-release drugs. The Chinese medicine gel provided by the present invention has good tissue compatibility and can be retained at the administration site for a long time. The present invention also adds a mucosal adhesive, and the addition of this component makes it have appropriate biological adhesion, can firmly adhere to the rectal mucosa, will not migrate to the end of the colon, and avoids the first-pass effect. The present invention also adds an absorption promoter, which can promote the efficacy of the Chinese medicine components and improve the bioavailability of the drug. At the same time, the Chinese medicine gel preparation is a rectal administration method, and rectal administration is simple, easy, safe and efficient.

[0025] Since the gel used for Chinese medicine administration needs to undergo a phase change within the rectal temperature range, from a liquid at room temperature or low temperature to a gel state, so as to be retained in the rectum, the gel preparation utilizes the dual reverse thermosensitive gelation property of poloxamer. By using poloxamer of a specific formula, namely poloxamer 407, poloxamer 108 and poloxamer 237, and adjusting the ratio of the three, the gel temperature can be adjusted, thereby better adapting to the temperature of the rectum and exerting the efficacy of the drug.

[0026] The Chinese medicine gel provided by the present invention has a significant improvement effect on ulcerative colitis and is superior to the drugs in the prior art. The preparation process of the Chinese medicine gel is simple, the use is convenient, the components are all pure Chinese medicine preparations without toxic side effects, and it has good clinical application prospects. DETAILED DESCRIPTION

[0027] The invention provides a Chinese medicine gel for treating ulcerative colitis. The gel is prepared from the following components in parts by weight: 4-8 parts of a Chinese medicine extract, 2-6 parts of a synergist, 2-4 parts of an adsorbent, 20-30 parts of a gel matrix, 0.10-0.15 parts of a preservative, and 60-80 parts of water; preferably, the gel comprises 5-7 parts of a Chinese medicine extract, 3-5 parts of a synergist, 3 parts of an adsorbent, 22-28 parts of a gel matrix, 0.11-0.14 parts of a preservative, and 64-76 parts of water; further preferably, the gel comprises 6 parts of a Chinese medicine extract, 4 parts of a synergist, 3 parts of an adsorbent, 24-26 parts of a gel matrix, 0.12-0.13 parts of a preservative, and 68-72 parts of water; and more preferably, the gel comprises 6 parts of a Chinese medicine extract, 4 parts of a synergist, 3 parts of an adsorbent, 25 parts of a gel matrix, 0.13 parts of a preservative, and 70 parts of water.

[0028] In the present invention, the traditional Chinese medicine extract comprises the following components in parts by weight: 50-70 parts of coptis chinensis, 20-40 parts of frankincense, 3-7 parts of sanguisorba officinalis, 3-7 parts of indigo naturalis, 50-70 parts of catechu, and 50-70 parts of Sanguisorba officinalis; preferably 54-66 parts of coptis chinensis, 24-36 parts of frankincense, 4-6 parts of sanguisorba officinalis, 4-6 parts of indigo naturalis, 54-66 parts of catechu, and 54-66 parts of Sanguisorba officinalis; further preferably 58-62 parts of coptis chinensis, 28-32 parts of frankincense, 4-6 parts of sanguisorba officinalis, 4-6 parts of indigo naturalis, 58-62 parts of catechu, and 58-62 parts of Sanguisorba officinalis; more preferably 60 parts of coptis chinensis, 30 parts of frankincense, 5 parts of sanguisorba officinalis, 5 parts of indigo naturalis, 60 parts of catechu, and 60 parts of Sanguisorba officinalis.

[0029] In the present invention, the synergist is eucalyptus oil, chitosan oligosaccharide and laurocaprol, and the mass ratio is 8-12:7-11:16-20; preferably 9-11:8-10:17-19; more preferably 10:9:18.

[0030] In the present invention, the adsorbent is hyaluronic acid and sodium alginate, with a mass ratio of 1-3:1-3; preferably 2:1-3; more preferably 1:1.

[0031] In the present invention, the gel matrix is: poloxamer 407, poloxamer 108 and poloxamer 237, and the mass ratio is 16-20:8-12:5-9; preferably 17-19:9-11:6-8; more preferably 18:10:7.

[0032] In the present invention, the preservative is benzalkonium bromide, sodium benzoate or potassium sorbate.

[0033] The present invention also provides a method for preparing the Chinese medicine gel for treating ulcerative colitis, comprising the following steps:

[0034] (1) mixing coptis root, frankincense, sanguisorba officinalis, indigo naturalis, catechu, and dragon's blood to obtain material 1; mixing material 1 with water and boiling, filtering to obtain a filtrate, concentrating the filtrate and drying to obtain a traditional Chinese medicine extract;

[0035] (2) mixing the Chinese medicine extract, synergist, adsorbent and water to obtain a drug solution;

[0036] (3) The drug solution, gel matrix and preservative are mixed and swollen to obtain a traditional Chinese medicine gel for treating ulcerative colitis.

[0037] In the present invention, the mass ratio of the material 1 to water in step (1) is 1:3-5, preferably 1:4.

[0038] In the present invention, the decocting time is 2 to 4 hours, preferably 3 hours.

[0039] In the present invention, the concentration in step (1) is: concentrated under reduced pressure to an extract having a relative density of 1.13 to 1.17 at 65°C; preferably 1.14 to 1.16; and more preferably 1.15.

[0040] In the present invention, the drying temperature in step (1) is 72-78°C and the drying time is 2-4h; preferably, the drying temperature is 73-77°C and the drying time is 3h; further preferably, the drying temperature is 74-76°C and the drying time is 3h; more preferably, the drying temperature is 75°C and the drying time is 3h.

[0041] In the present invention, the swelling temperature of step (3) is 5-7°C and the time is 20-26h; preferably, the swelling temperature is 6°C and the time is 21-25h; further preferably, the swelling temperature is 6°C and the time is 22-24h; more preferably, the swelling temperature is 6°C and the time is 23h.

[0042] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0043] Example 1

[0044] A Chinese medicine gel for treating ulcerative colitis is prepared from the following components by weight: 4 parts of Chinese medicine extract, 2 parts of synergist, 2 parts of adsorbent, 20 parts of gel matrix, 0.1 parts of potassium sorbate, and 60 parts of water;

[0045] The traditional Chinese medicine extract is composed of the following components in parts by weight: 50 parts of coptis root, 20 parts of frankincense, 3 parts of sanguisorba officinalis, 3 parts of indigo naturalis, 50 parts of catechu, and 50 parts of dragon's blood.

[0046] The synergist is eucalyptus oil, chitosan oligosaccharide and laurocapram, and the mass ratio is 8:7:16.

[0047] The adsorbent is hyaluronic acid and sodium alginate, with a mass ratio of 3:1.

[0048] The gel matrix is: poloxamer 407, poloxamer 108 and poloxamer 237, with a mass ratio of 16:8:5.

[0049] The preparation method of the traditional Chinese medicine gel for treating ulcerative colitis comprises the following steps:

[0050] (1) Mixing coptis root, frankincense, sanguisorba officinalis, indigo naturalis, catechu, and dragon's blood to obtain material 1; mixing material 1 with water in a mass ratio of 1:3 and boiling for 2 hours, filtering to obtain a filtrate, decompressing the filtrate to an extract with a relative density of 1.13 at 65° C., and drying at 72° C. for 2 hours to obtain a traditional Chinese medicine extract;

[0051] (2) mixing the Chinese medicine extract, synergist, adsorbent and water to obtain a drug solution;

[0052] (3) The drug solution, gel matrix and potassium sorbate are mixed and swelled at 5° C. for 20 hours to obtain a traditional Chinese medicine gel for treating ulcerative colitis.

[0053] Example 2

[0054] A Chinese medicine gel for treating ulcerative colitis is prepared from the following components by weight: 8 parts of a Chinese medicine extractant, 6 parts of a synergist, 4 parts of an adsorbent, 30 parts of a gel matrix, 0.15 parts of sodium benzoate, and 80 parts of water;

[0055] The traditional Chinese medicine extract is composed of the following components in parts by weight: 70 parts of coptis root, 40 parts of frankincense, 7 parts of sanguisorba officinalis, 7 parts of indigo naturalis, 70 parts of catechu, and 70 parts of dragon's blood.

[0056] The synergist is eucalyptus oil, chitosan oligosaccharide and laurocapram, and the mass ratio is 12:11:20.

[0057] The adsorbent is hyaluronic acid and sodium alginate, with a mass ratio of 3:1.

[0058] The gel matrix is: poloxamer 407, poloxamer 108 and poloxamer 237, with a mass ratio of 20:12:9.

[0059] The preparation method of the traditional Chinese medicine gel for treating ulcerative colitis comprises the following steps:

[0060] (1) Mixing coptis root, frankincense, sanguisorba officinalis, indigo naturalis, catechu, and dragon's blood to obtain material 1; mixing material 1 with water in a mass ratio of 1:5 and boiling for 4 hours, filtering to obtain a filtrate, decompressing the filtrate to an extract with a relative density of 1.17 at 65° C., and drying at 78° C. for 4 hours to obtain a traditional Chinese medicine extract;

[0061] (2) mixing the Chinese medicine extract, synergist, adsorbent and water to obtain a drug solution;

[0062] (3) The drug solution, gel matrix and sodium benzoate are mixed and swelled at 7° C. for 26 hours to obtain a traditional Chinese medicine gel for treating ulcerative colitis.

[0063] Example 3

[0064] A Chinese medicine gel for treating ulcerative colitis is prepared from the following components by weight: 6 parts of a Chinese medicine extractant, 4 parts of a synergist, 3 parts of an adsorbent, 25 parts of a gel matrix, 0.13 parts of benzalkonium bromide, and 70 parts of water;

[0065] The traditional Chinese medicine extract is composed of the following components in parts by weight: 60 parts of coptis root, 30 parts of frankincense, 5 parts of sanguisorba officinalis, 5 parts of indigo naturalis, 60 parts of catechu, and 60 parts of dragon's blood.

[0066] The synergist is eucalyptus oil, chitosan oligosaccharide and laurocapram, and the mass ratio is 10:9:18.

[0067] The adsorbent is hyaluronic acid and sodium alginate, with a mass ratio of 1:1.

[0068] The gel matrix is: poloxamer 407, poloxamer 108 and poloxamer 237, with a mass ratio of 18:10:7.

[0069] The preparation method of the traditional Chinese medicine gel for treating ulcerative colitis comprises the following steps:

[0070] (1) Mixing coptis root, frankincense, sanguisorba officinalis, indigo naturalis, catechu, and dragon's blood to obtain material 1; mixing material 1 with water in a mass ratio of 1:4 and boiling for 3 hours, filtering to obtain a filtrate, decompressing the filtrate to an extract with a relative density of 1.15 at 65° C., and drying at 75° C. for 3 hours to obtain a traditional Chinese medicine extract;

[0071] (2) mixing the Chinese medicine extract, synergist, adsorbent and water to obtain a drug solution;

[0072] (3) The drug solution, gel matrix and benzalkonium bromide are mixed and swelled at 6° C. for 23 hours to obtain a traditional Chinese medicine gel for treating ulcerative colitis.

[0073] Experimental Example 1

[0074] The efficacy of Chinese medicine gel was verified using the TNBS-induced acute colitis model in rats

[0075] The modeling method of TNBS-induced acute colitis in rats is as follows:

[0076] After acclimation for 7 days, rats were fasted for 48 hours and then anesthetized with sodium pentobarbital (40 mg / kg, ip). A blunt cannula was inserted into the rat anus, and the tip was pushed forward about 8 cm. TNBS (100 mg / kg) was injected into the colon via cannula. After the instillation of TNBS solution, the rats were placed head down for 30 minutes to prevent instillation leakage in the colon. Rats in the blank control group were instilled with normal saline in the colon.

[0077] Among them, the traditional Chinese medicine gel prepared by the method of Example 3 was used as the experimental group;

[0078] Control group 1: other methods are the same as those in Example 3, except that the adsorbent is replaced by an equal amount of carboxymethyl cellulose.

[0079] Control group 2: other methods are the same as those in Example 3, except that the synergist is replaced by equal amounts of eucalyptus oil and laurocapram, with a mass ratio of 1:1.

[0080] Control group 3: other methods were the same as those in Example 3, except that the gel matrix was replaced with equal amounts of poloxamer 407 and poloxamer 108, with a mass ratio of 1:0.6.

[0081] Control group 4: other methods are the same as those of Example 3, except that coptis chinensis and indigo naturalis are replaced by equal amounts of scutellaria baicalensis and lithospermum officinale.

[0082] Control group 5: other methods were the same as those in Example 3, except that catechu and dragon's blood were replaced with an equal amount of distilled water.

[0083] The prior art group took mesalazine tablets in accordance with the doctor's advice.

[0084] The model group was treated with an equal volume of normal saline enema.

[0085] The rats were divided into a modeling group and a blank control group, and the modeling group was further randomly divided into an experimental group, a control group 1 to a control group 5, and a model group, with 8 rats in each group. Enema administration began 24 hours after modeling, once a day, for 14 consecutive days.

[0086] The rats were weighed on the 1st, 7th, 11th and 14th days of the experiment, and the fecal characteristics and fecal occult blood of the rats were observed. The DAI score was performed according to the DAI score table in Table 1, and the DAI score of each rat was calculated to evaluate the disease recovery. The average value was taken. The results are shown in Table 2.

[0087] DAI = (percentage of weight loss + stool consistency + fecal occult blood) / 3.

[0088] The colon tissue was cut in half longitudinally, and a 10% (W / V) tissue homogenate was prepared with pre-cooled physiological saline. The mixture was centrifuged at 4°C, 3000 r / min for 10 min, and the supernatant was taken. The contents of IL-17A, IFN-γ, IL-6 and EGF in the colon tissue were detected according to the instructions of the relevant kits. The average values ​​were taken. The results are shown in Table 3.

[0089] Table 1 DAI score

[0090] Group Percentage of weight loss Stool consistency Fecal occult blood 0 0％ normal Negative 1 1～5％ Soft stools Light blue 2 5～10％ Mucoid stool blue 3 10～20％ Thin liquid stool Dark Blue 4 ＞20％ / Naked bloody stool

[0091] Table 2 DAI score statistics

[0092] Group 1d 7d 14d Blank control group 0.88 0.75 0.38 Model Group 3.58 3.35 3.12 Experimental Group 3.71 2.51 1.78 Control group 1 3.61 2.79 1.93 Control group 2 3.53 2.75 1.91 Control group 3 3.69 3.05 2.24 Control group 4 3.67 2.66 1.88 Control group 5 3.64 3.17 2.56 Existing Technology Group 3.62 2.57 1.82

[0093] Table 3 Expression of related factors

[0094]

[0095]

[0096] It can be seen from the records in Tables 2 and 3 that the traditional Chinese medicine gel obtained by the method of the present invention can significantly reduce the DAI score of rats, significantly reduce the expression levels of IL-17A, IFN-γ, and IL-6, and significantly increase the content of EGF. The gel has a significant improvement effect on ulcerative colitis and is superior to the drugs in the prior art.

[0097] It can be seen from the data of the control group that only by adopting the complete Chinese medicine gel formula of the present invention can the best therapeutic effect be achieved. If some components are discarded or replaced with components with similar efficacy, the therapeutic effect of the gel will be significantly affected.

[0098] Experimental Example 2

[0099] A total of 60 patients with ulcerative colitis were selected, with an age range of 25 to 45 years. The clinical symptoms included recurrent diarrhea, bloody and mucous stools, abdominal pain, tenesmus, etc. Colonoscopy showed multiple superficial ulcers in the colon mucosa, accompanied by congestion and edema, as well as systemic manifestations such as fever and tachycardia.

[0100] The experimental group, control group 4 and prior art group were the same as those in Experimental Example 1. 20 patients in each group were randomly given enema, once a day, for 14 consecutive days. After the treatment, the recovery of the patients was investigated, and the results are shown in Table 4.

[0101] Obviously effective: clinical symptoms disappeared, and colonoscopy showed normal mucosa. Partially effective: clinical symptoms basically disappeared, and colonoscopy showed mild inflammatory reaction of mucosa and partial pseudopolyp formation. Ineffective: clinical symptoms, endoscopic and pathological examinations did not improve after treatment.

[0102] Table 4 Patient recovery status questionnaire

[0103]

[0104]

[0105] It can be seen from the records in Table 4 that the Chinese medicine gel prepared by the method of the present invention has an excellent therapeutic effect on ulcerative colitis, and its therapeutic effect is better than the drugs in the prior art. It can be seen from the data of control group 4 that only the complete formula of the present invention can achieve the best therapeutic effect, and even if it is replaced with other drugs with similar effects, it will have a significant impact on the efficacy of the drugs.

[0106] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine gel for treating ulcerative colitis, characterized in that: The method is prepared from the following components by weight: 4 to 8 parts of a Chinese medicine extractant, 2 to 6 parts of a synergist, 2 to 4 parts of an adsorbent, 20 to 30 parts of a gel matrix, 0.10 to 0.15 parts of a preservative, and 60 to 80 parts of water; The traditional Chinese medicine extract comprises the following components in parts by weight: 50-70 parts of coptis root, 20-40 parts of frankincense, 3-7 parts of sanguisorba officinalis, 3-7 parts of indigo naturalis, 50-70 parts of catechu, and 50-70 parts of dragon's blood.

2. A Chinese medicine gel for treating ulcerative colitis according to claim 1, characterized in that: The synergist is eucalyptus oil, chitosan oligosaccharide and laurocapram, and the mass ratio is 8-12:7-11:16-20.

3. A Chinese medicine gel for treating ulcerative colitis according to claim 1, characterized in that: The adsorbent is hyaluronic acid and sodium alginate, with a mass ratio of 1-3:1-3.

4. A Chinese medicine gel for treating ulcerative colitis according to claim 1, characterized in that: The gel matrix comprises: poloxamer 407, poloxamer 108 and poloxamer 237, and the mass ratio is 16-20:8-12:5-9.

5. A Chinese medicine gel for treating ulcerative colitis according to claim 1, characterized in that: The preservative is benzalkonium bromide, sodium benzoate or potassium sorbate.

6. The method for preparing a traditional Chinese medicine gel for treating ulcerative colitis according to any one of claims 1 to 5, characterized in that: The steps include: (1) Mixing coptis root, frankincense, sanguisorba officinalis, indigo naturalis, catechu, and dragon's blood to obtain material 1; mixing material 1 with water and boiling, filtering to obtain a filtrate, concentrating the filtrate and drying it to obtain a traditional Chinese medicine extract; (2) mixing the Chinese medicine extract, synergist, adsorbent and water to obtain a drug solution; (3) The drug solution, gel matrix and preservative are mixed and swollen to obtain a traditional Chinese medicine gel for treating ulcerative colitis.

7. The method for preparing a traditional Chinese medicine gel for treating ulcerative colitis according to claim 6, characterized in that: In step (1), the mass ratio of material 1 to water is 1:3-5; and the decoction time is 2-4 hours.

8. The method for preparing a traditional Chinese medicine gel for treating ulcerative colitis according to claim 6, characterized in that: The concentration in step (1) is as follows: concentrating under reduced pressure to an extract having a relative density of 1.13 to 1.17 at 65°C.

9. The method for preparing a traditional Chinese medicine gel for treating ulcerative colitis according to claim 6, characterized in that: The drying temperature in step (1) is 72-78° C. and the drying time is 2-4 hours.

10. The method for preparing a traditional Chinese medicine gel for treating ulcerative colitis according to claim 6, characterized in that: The swelling temperature in step (3) is 5 to 7° C. and the swelling time is 20 to 26 hours.

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