Stem cell composition with knee joint injury repairing function and preparation method thereof

By adding anti -NGF antibodies to stem cell therapy, combined with optimized stem cell preparation and activation methods, the problem of unable to effectively repair knee cartilage and relieve pain in existing technology, and achieve effective repair and pain relief of knee injury.

CN119371529AActive Publication Date: 2025-01-28SHANDONG QINGRUI BIOTECHNOLOGY CO LTD
View PDF 2 Cites 1 Cited by

Patent Information

Application Number
CN202411530670.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-10-30
Publication Date
2025-01-28
Estimated Expiration
2044-10-30

AI Technical Summary

Technical Problem

Existing treatments for knee injury, especially osteoarthritis (OA), can only relieve symptoms, cannot effectively repair cartilage, and stem cell therapy has problems with safety and application risks.

Method used

Provide a stem cell composition, including mesenchymal stem cells and anti -NGF antibodies. By optimizing the preparation and activation method of stem cells, combining anti -NGF antibodies, it is used to treat knee joint injury.

Benefits of technology

This composition can effectively promote the proliferation and repair of cartilage cells, inhibit the expression of inflammatory factors, relieve pain symptoms, and significantly improve the pathological state of the knee joint.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN119371529A_ABST
    Figure CN119371529A_ABST
Patent Text Reader

Abstract

The invention provides a stem cell composition with a knee joint injury repair function and a preparation method thereof, the stem cell composition comprises mesenchymal stem cells and an anti-NGF antibody, the anti-NGF antibody comprises a heavy chain variable region with an amino acid sequence shown as SEQ ID NO: 1 and a light chain variable region with an amino acid sequence shown as SEQ ID NO: 2; the mesenchymal stem cells are adipose mesenchymal stem cells and are subjected to activation treatment. The activated adipose-derived mesenchymal stem cells are combined with an anti-NGF antibody for use, so that the gonitis repair can be promoted, the expression of inflammatory factors can be inhibited, and the pain symptom can be relieved.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Stem cell preparation for repairing knee joint injury and preparation process thereof

    CN116836276A

  • Method of growing mesenchymal stem cells from bone marrow

    US20090004661A1

Cited By

  • Stem cell exosome and application thereof in preparation of medicine for preventing and treating bone and joint diseases of pets

    CN120227454A