Nucleic acid POCT detector

Abstract

The invention discloses a nucleic acid POCT (point-of-care testing) detector. A detection device of the detector comprises a consumable bin, a movable mechanical arm module, a nucleic acid extraction and purification module and an amplification detection module, the movable mechanical arm module is provided with a magnetic rod position for mounting a magnetic rod, a suction nozzle position and a first clamping jaw; the amplification detection module is used for carrying out amplification and real-time fluorescence detection on nucleic acid in the to-be-detected sample. The invention provides a detector which can automatically complete nucleic acid detection. The detector is provided with a plurality of detection channels, can detect one or more samples at the same time, adopts the technical means of top-speed heating and cooling, rapid and accurate constant temperature, photoelectric signal denoising and amplification and the like, achieves high integration and high automation, reduces the volume to the limit, can automatically complete nucleic acid detection of 1 to 21 pathogens in the whole process from the sample to the result within 30 minutes, and has a wide application prospect. And a result can be sent. Compared with a traditional fluorescent PCR method, the method has the advantages that the detection time is greatly shortened, the convenience is greatly improved, the requirements on professionals and places are very low, and the application range is very wide.

Description

Technical Field

[0001] The present invention relates to the technical field of nucleic acid detection instruments, and in particular to a nucleic acid POCT detector. Background Art

[0002] In the prior art, generally, a tester sucks up a sample with a nozzle, drops the sample into a reaction tube, and uses a PCR amplification detector to perform nucleic acid testing.

[0003] However, this detection method relies heavily on manual operation, which is inefficient and may lead to inaccurate test results due to improper operation. Summary of the invention

[0004] The main purpose of the present invention is to provide a nucleic acid POCT detector, aiming to realize the automation of nucleic acid detection, improve detection efficiency, and improve the accuracy of detection results.

[0005] To achieve the above object, the present invention provides a nucleic acid POCT detector, comprising at least one detection device, wherein the detection device comprises:

[0006] Loading platform;

[0007] A consumables bin is disposed on the carrier platform and is provided with a reagent tank accommodating position for accommodating a reagent tank, a sample tube accommodating position for accommodating a sample tube, and a reaction tube accommodating position for accommodating a reaction tube;

[0008] a mobile robot module, which is installed on the carrier and is provided with a magnetic rod position for installing a magnetic rod, a nozzle position for installing a nozzle, and a first clamping claw for clamping the reaction tube and / or the sample tube and performing cover opening / closing processing on the reaction tube and / or the sample tube; and

[0009] The amplification detection module is arranged on the supporting platform and is provided with a detection slot for accommodating the reaction tube. The amplification detection module is used for amplifying the nucleic acid in the sample to be detected and performing real-time fluorescence detection.

[0010] Optionally, the nucleic acid POCT detector further includes a first driving mechanism, which is drivingly connected to the consumables bin and is used to drive the consumables bin to slide in and out relative to the supporting platform.

[0011] Optionally, the mobile robotic arm module includes a slide rail, a slider, a second drive mechanism, a third drive mechanism and a fourth drive mechanism. The slider is slidably arranged on the slide rail and is drive-connected to the second drive mechanism. The second drive mechanism is used to drive the slider to slide. The first clamp is arranged on the slider and is drive-connected to the third drive mechanism and the fourth drive mechanism respectively. The third drive mechanism is used to drive the first clamp to open and close. The fourth drive mechanism is used to drive the first clamp to rotate to open / close the cover.

[0012] Optionally, the sample tube accommodating position is composed of a second clamping jaw disposed on the supporting platform, and the second clamping jaw is drivingly connected to a fifth driving mechanism, and the fifth driving mechanism is used to drive the second clamping jaw to open and close.

[0013] Optionally, a movable light blocking member is provided at the notch of the detection slot, and the first clamping jaw is further used to clamp or push the movable light blocking member and move the movable light blocking member under the drive of the second driving mechanism.

[0014] Optionally, the mobile robotic arm module also includes a magnetic rod mounting block and a sixth driving mechanism. The magnetic rod is located on the magnetic rod mounting block. The magnetic rod mounting block can be lifted and lowered on the slider and is drivingly connected to the sixth driving mechanism. The sixth driving mechanism is used to drive the magnetic rod mounting block to perform lifting and lowering movements.

[0015] Optionally, the mobile robotic arm module also includes a nozzle mounting block and a seventh driving mechanism. The nozzle is arranged on the nozzle mounting block. The nozzle mounting block can be raised and lowered on the slider and is connected to the seventh driving mechanism. The seventh driving mechanism is used to drive the nozzle mounting block to perform lifting and lowering movements.

[0016] Optionally, the consumables bin further includes a consumables rack, which is mounted on the supporting platform and is provided with a plurality of magnetic rod slots for placing the magnetic rods and a plurality of nozzle slots for placing the nozzles.

[0017] Optionally, the nucleic acid POCT detector further includes a heating device, which is disposed at the bottom of the reagent tank and is used to heat and amplify the sample to be tested.

[0018] Optionally, the nucleic acid POCT detector further includes a barcode scanner, which is disposed on the supporting platform and close to the sample tube accommodating position, and is used to identify sample information of the sample tube.

[0019] In the technical solution of the present invention, the nucleic acid POCT detector includes a carrier and at least one detection device arranged on the carrier, and the detection devices all include a consumables bin, a mobile mechanical arm module and an amplification detection module; the consumables bin is arranged on the carrier and is provided with a reagent tank accommodating position for placing a reagent tank, a sample tube accommodating position for placing a sample tube and a reaction tube accommodating position for placing a reaction tube; the mobile mechanical arm module is installed on the carrier and is provided with a magnetic rod position for installing a magnetic rod, a nozzle position for installing a suction nozzle and a first clamp for clamping a reaction tube and / or a sample tube and opening / closing the cover thereof; the amplification detection module is arranged on the carrier and is provided with a detection slot for accommodating a reaction tube, and the amplification detection module is used to amplify and perform real-time fluorescence detection on the nucleic acid in the sample to be tested. It can be understood that the present invention can perform nucleic acid detection on at least one sample at the same time by setting at least one detection device, and the operations such as opening / closing the cover, sampling, extraction, and detection are all automatically completed by the machine, which greatly improves the efficiency of nucleic acid detection, realizes the automation of nucleic acid detection, and effectively avoids inaccurate detection results due to improper operation, thereby improving the accuracy of the detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0021] Figure 1 This is a schematic diagram of the structure of an embodiment of a four-channel nucleic acid POCT detector of the present invention;

[0022] Figure 2 This is a schematic structural diagram of an embodiment of a dual-channel nucleic acid POCT detector of the present invention;

[0023] Figure 3 It is a schematic diagram of the structure of the reaction tube in one embodiment of the dual-channel nucleic acid POCT detector of the present invention.

[0024] Description of Figure Numbers:

[0025] 100, carrier; 200, detection device; 10, consumables bin; 20, mobile robot module; 30, amplification detection module; 101, reagent tank storage position; 102, sample tube storage position; 103, reaction tube storage position; 201, magnetic rod position; 202, nozzle position; 203, first clamp; 301, detection tank; 221, slide rail; 222, slider; 223, second drive mechanism; 224, third drive mechanism Driving mechanism; 225, fourth driving mechanism; 104, consumables rack; 105, fifth driving mechanism; 302, movable light blocking member; 228, first driving mechanism; 226, sixth driving mechanism; 227, seventh driving mechanism; 110, container body; 120, light-transmitting member; 130, cover; 10a, notch; 10b, flow channel; 111, detection hole; 11, round tube; 12, diverter plate; 112, convex column.

[0026] The realization of the purpose, functional features and advantages of the present invention will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0027] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0029] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0030] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the meaning of "and / or" appearing in the full text is to include three parallel solutions. Taking "A and / or B" as an example, it includes solution A, or solution B, or a solution that satisfies both A and B. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in this field to implement. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0031] The present invention provides a nucleic acid POCT detector for detecting nucleic acids of pathogens, which is not limited here.

[0032] Reference Figure 1 and Figure 2 In some embodiments of the present invention, the nucleic acid POCT detector includes a carrier 100 and at least one detection device 200 disposed on the carrier 100, and the detection device 200 includes a consumables bin 10, a mobile mechanical arm module 20, and an amplification detection module 30; the consumables bin 10 is disposed on the carrier 100 and is provided with a reagent tank accommodating position 101 for placing a reagent tank, a sample tube accommodating position 102 for placing a sample tube, and a reaction tube accommodating position 103 for placing a reaction tube; the mobile mechanical arm module 20 is installed on the carrier 100 and is provided with a magnetic rod position 201 for installing a magnetic rod, a nozzle position 202 for installing a nozzle, and a first clamp 203 for clamping a reaction tube and / or a sample tube and opening / closing the cover thereof; the amplification detection module 30 is disposed on the carrier 100 and is provided with a detection tank 301 for accommodating a reaction tube, and the amplification detection module 30 is used to amplify and perform real-time fluorescence detection on the nucleic acid in the sample to be tested. Among them, the magnetic rod, the nozzle, the reagent tank, etc. constitute a nucleic acid extraction and purification module.

[0033] In this embodiment, the above-mentioned accommodating positions can be slot structures, clamping structures, supporting structures, etc., which are not limited here.

[0034] In this embodiment, the magnetic rod and the suction nozzle can be installed in a detachable manner such as snap-on, plug-in, etc., which is not limited here.

[0035] In this embodiment, the nucleic acid POCT detector is further provided with a heating device, which is arranged at the bottom of the reagent tank and is used to heat and amplify the sample to be tested.

[0036] When conducting nucleic acid testing, the mobile robotic arm module 20 is equipped with a suction nozzle and moves to the sample tube holding position 102 to absorb the sample, and then moves it to the reagent tank holding position 101 to drop it into the reagent tank, and then the mobile robotic arm module 20 is equipped with a magnetic rod and inserted into the reagent tank for adsorption, waiting for the nucleic acid to be heated and amplified. At the same time, the mobile robotic arm module 20 can carry the first clamp 203 to open / close the lid of the reaction tube, and then use the suction nozzle to absorb the test solution into the reaction tube, and finally perform fluorescence detection on the test sample.

[0037] It can be understood that the present invention, by providing at least one detection device 200, can perform nucleic acid detection on at least one sample at the same time, and operations such as opening / closing the cover, sampling, extraction, and detection are all automatically completed by the machine, which greatly improves the efficiency of nucleic acid detection, realizes the automation of nucleic acid detection, and effectively avoids inaccurate detection results due to improper operation, thereby improving the accuracy of the detection results.

[0038] To facilitate the placement of consumables and further improve the convenience of operation, refer to Figure 1 and Figure 2 In some embodiments, the nucleic acid POCT detector further includes a first driving mechanism 228 , which is drivingly connected to the consumable bin 10 and is used to drive the consumable bin 10 to slide in and out relative to the carrier 100 .

[0039] In this embodiment, the first drive mechanism 228 and the following second drive mechanism 223, third drive mechanism 224, fourth drive mechanism 225, fifth drive mechanism 105, sixth drive mechanism 226, and seventh drive mechanism 227 can use motors, cylinders, oil cylinders, etc., which are not limited here.

[0040] Reference Figure 1 and Figure 2In some embodiments, the mobile mechanical arm module 20 may include a slide rail 221, a slider 222, a second drive mechanism 223, a third drive mechanism 224, and a fourth drive mechanism 225. The slider 222 is slidably arranged on the slide rail 221 and is driven and connected to the second drive mechanism 223. The second drive mechanism 223 is used to drive the slider 222 to slide. The first clamp 203 is arranged on the slider 222 and is driven and connected to the third drive mechanism 224 and the fourth drive mechanism 225 respectively. The third drive mechanism 224 is used to drive the first clamp 203 to open and close, and the fourth drive mechanism 225 is used to drive the first clamp 203 to rotate to open / cover the lid of the reaction tube, wherein the bottom of the reaction tube can be limited by its corresponding slot. In addition, the first clamp 203 can also be provided with an independent lifting motor to facilitate the clamping of items. In this way, the first clamp 203 can slide along the length direction of the slide rail 221, and can perform lifting and lowering movements, and also has the function of opening / closing the lid, which further improves the automation of the nucleic acid POCT detector and greatly improves the detection efficiency.

[0041] Specifically, the first clamping jaw 203 of this embodiment may include a mounting seat, an insertion rod and two clamping blocks, one end of the insertion rod is connected to the third driving mechanism 224, the other end of the insertion rod is movably inserted in the mounting seat and is provided with two inclined surfaces, the two clamping blocks are relatively arranged on the mounting seat and both abut against the inclined surfaces on the insertion rod, and the mounting seat is connected to the fourth driving mechanism 225 through a belt transmission mechanism. In this way, the opening and closing of the first clamping jaw 203 is realized to match the clamping requirements of liquid tubes or bottles of different sizes and meet the requirements of automatic opening / closing of the cover, and the applicability is wider.

[0042] In addition, in order to reduce the damage caused by collision between the moving parts of the drive mechanism and other parts and to increase the service life, refer to Figure 1 and Figure 2 In some embodiments, a lifting block may be provided at the output end of each driving member that performs lifting motion, and a buffer member such as a spring may be provided between the lifting block and the fixed seat of the corresponding driving member.

[0043] In order to facilitate the placement and removal of sample tubes and realize the function of automatically opening / closing the tube cover of the sample tube, the degree of automation is further improved. Based on the above embodiment, the sample tube accommodating position 102 is composed of a second clamping jaw provided on the carrier 100, and the second clamping jaw is connected to the fifth driving mechanism 105 for driving the second clamping jaw to open and close. In this embodiment, the first clamping jaw 203 and the second clamping jaw can be used in conjunction with each other, the second clamping jaw clamps the bottom of the sample tube, the first clamping jaw 203 clamps the cover, and then performs a rotational motion to open / close the cover of the sample tube.

[0044] To avoid light interference with fluorescence detection and to further improve the accuracy of the test results, refer to Figure 1 and Figure 2In some embodiments, a movable light blocking member 302 is provided at the notch of the detection slot 301 , and the first clamping jaw 203 is further used to clamp or push the movable light blocking member 302 and move the movable light blocking member 302 under the drive of the second driving mechanism 223 .

[0045] In order to further improve the automation level of the nucleic acid POCT detector, improve detection efficiency, and save labor costs, refer to Figure 1 and Figure 2 In some embodiments, the mobile robotic arm module 20 may further include a magnetic rod mounting block and a sixth driving mechanism 226. The magnetic rod position 201 is arranged on the magnetic rod mounting block. The magnetic rod mounting block can be lifted and lowered on the slider 222 and is connected to the sixth driving mechanism 226. The sixth driving mechanism 226 is used to drive the magnetic rod mounting block to perform lifting and lowering movements.

[0046] In this embodiment, the mobile robot arm module 20 also includes a nozzle mounting block and a seventh driving mechanism 227. The nozzle position 202 is arranged on the nozzle mounting block. The nozzle mounting block can be raised and lowered on the slider 222 and is connected to the seventh driving mechanism 227. The seventh driving mechanism 227 is used to drive the nozzle mounting block to perform lifting and lowering movements.

[0047] To facilitate the placement and retrieval of various testing consumables to further improve the testing efficiency, in some embodiments, the consumable bin 10 also includes a consumable rack 104, which is installed on the carrier 100 and is provided with a plurality of magnetic rod slots for placing magnetic rods and a plurality of nozzle slots for placing nozzles.

[0048] To print the test report automatically, refer to Figure 1 and Figure 2 In some embodiments, the nucleic acid POCT detector also includes a barcode scanner and a printer, which are respectively arranged on the carrier 100. The barcode scanner is arranged near the sample tube accommodating position 102. The barcode scanner is used to identify the sample information of the sample tube, and the printer is used to print the test report.

[0049] In addition, the single-portion pre-packaged nucleic acid extraction and membrane-walled PCR amplification reaction tube used in conjunction with the nucleic acid POCT detection instrument of the present invention is an original product and is suitable for automated operation. The present invention proposes a new PCR reaction tube:

[0050] Reference Figure 3 In one embodiment, the reaction tube includes a container body 110 and a light-transmitting member 120. The container body 110 is provided with a liquid inlet, at least two notches 10a, and a flow channel 10b connecting the liquid inlet and the at least two notches 10a. The light-transmitting member 120 is arranged at the notch 10a of the container body 110, and is surrounded by the notch 10a to form at least two detection holes 111.

[0051] In this embodiment, the reaction tube may further include a cover 130, which is screwed onto the liquid inlet of the container body 110. The container body 110 and the cover 130 may be made of medical plastic material, and the light-transmitting member 120 may be made of medical-grade PPMA, PC, etc., which are not limited here.

[0052] The number of the notches 10a in this embodiment is preferably 7, which can simultaneously meet the requirements of nucleic acid detection of 21 pathogens. The notches 10a are all opened at the edge of the container body 110 away from the liquid inlet and are evenly spaced.

[0053] During manufacturing, the light-transmitting member 120 and the container body 110 may be formed by injection molding, the light-transmitting member 120 may be snapped onto the container body 110 , may be adhered to the container body 110 , or may be welded to the container body 110 .

[0054] It can be understood that the present invention provides a reaction tube having multiple detection holes 111, which can meet the requirements of the reaction tube for simultaneously detecting nucleic acids of multiple pathogens. The multiple detection holes 111 are set one-to-one with the detection light channels of multiple detectors. During fluorescence detection, light is emitted to the nucleic acid of the sample to be tested in the detection holes 111 through the light-transmitting member 120, and 1 to 21 pathogen nucleic acids can be detected at the same time, thereby greatly improving the detection efficiency, greatly shortening the time for pathogen nucleic acid detection, significantly improving the convenience, and greatly shortening the diagnosis cycle.

[0055] In order to save materials and facilitate processing, and meet the needs of simultaneous detection of nucleic acids of multiple pathogens, refer to Figure 3 In one embodiment, the container body 110 may include a circular tube 11 and a diverter plate 12 integrally formed with the circular tube 11 , the liquid inlet is disposed at one end of the circular tube 11 , and the flow channel 10 b and the notch 10 a are disposed on the diverter plate 12 .

[0056] In this embodiment, the light-transmitting member 120 may be in a U-shaped strip to surround all the gaps 10a at the same time, which is convenient for assembly and has better sealing performance. Of course, in some other embodiments, multiple light-transmitting components may be used to respectively seal the multiple gaps 10a at the edge of the diverter plate 12, and the number and shape of the light-transmitting member 120 are not limited here.

[0057] In addition, in order to improve the stability of the detector's electric clamp holding the reaction tube, refer to Figures 1 to 3 In some embodiments, the circular tube 11 is provided with a protrusion 112 extending along its radial direction, and when the electric clamp is clamping, the protrusion 112 of the reaction tube is inserted into the corresponding socket of the electric clamp.

[0058] In this embodiment, a detection light channel is provided at the detection hole 111 corresponding to the reaction tube in the detection tank 301. This arrangement can complete 1 to 21 types of pathogen nucleic acid detection at the same time, greatly improve the detection efficiency, greatly shorten the time of pathogen nucleic acid detection, significantly improve convenience, and ensure the accuracy of the detection results.

[0059] In summary, the nucleic acid POCT detector of the present invention has at least the following beneficial effects:

[0060] The nucleic acid POCT detection instrument of the present invention is fully automated from sample loading to result reporting, and does not require professional operation. In addition to being suitable for use in hospitals, it can also be used in non-medical institutions such as communities, airports, docks, customs, and even in homes.

[0061] The nucleic acid POCT detection instrument of the present invention has multiple positions and can detect 1 to 4 samples, or more samples, at the same time. It can detect multiple channels at the same time and the detection time is 15 to 30 minutes. It is currently the fastest instrument for pathogen nucleic acid detection.

[0062] The nucleic acid POCT detection instrument of the present invention is based on an original structural design and core algorithm, which can achieve extremely fast temperature rise and fall, fast and accurate constant temperature, photoelectric signal noise removal and amplification, and is highly integrated and highly automated with infinitely reduced size.

[0063] The nucleic acid POCT detector of the present invention has multiple detection channels, can detect one or more samples at the same time, and adopts technical means such as extremely fast temperature rise and fall, fast and accurate constant temperature, photoelectric signal noise removal and amplification, etc., to achieve high integration, high automation and extremely small volume. It can automatically complete 1 to 21 pathogen nucleic acid detection from sample to result within 30 minutes, and can print and send the results. Compared with the traditional fluorescent PCR method, the detection time is greatly shortened, the convenience is greatly improved, and the requirements for professionals and places are very low, so it has a wide range of applications.

[0064] The nucleic acid POCT detector of the present invention integrates opening the cover and adding samples, nucleic acid extraction, PCR amplification detection, etc. After the original sample tube is started on the machine, it can automatically scan the code, open / close the cover, add samples, extract, build a PCR reaction system, close the cover, centrifuge to defoam, put on the machine, and detect. The results are obtained in 15 to 30 minutes and automatically transmitted, greatly shortening the detection time. The nucleic acid POCT detection instrument of the present invention can automatically detect pathogens in samples in a short time, which will greatly improve the diagnosis, treatment or prevention and control level of infectious diseases, provide a new method for reducing medical expenses, help the health strategy, and continue to enhance the competitiveness of molecular diagnostic products.

[0065] The above descriptions are only optional embodiments of the present invention, and are not intended to limit the patent scope of the present invention. All equivalent structural changes made using the contents of the present invention's specification and drawings, or directly / indirectly applied in other related technical fields, are included in the patent protection scope of the present invention.

Claims

1. A nucleic acid POCT detector, characterized in that: It includes a carrying platform and at least one detection device arranged on the carrying platform, and the detection device includes: A consumables bin is disposed on the carrier platform and is provided with a reagent tank accommodating position for placing a reagent tank, a sample tube accommodating position for placing a sample tube, and a reaction tube accommodating position for placing a reaction tube; a mobile robot module, which is installed on the carrier and is provided with a magnetic rod position for installing a magnetic rod, a nozzle position for installing a nozzle, and a first clamping claw for clamping the reaction tube and / or the sample tube and performing cover opening / closing processing on the reaction tube and / or the sample tube; and The amplification detection module is arranged on the supporting platform and is provided with a detection slot for accommodating the reaction tube. The amplification detection module is used for amplifying the nucleic acid in the sample to be detected and performing real-time fluorescence detection.

2. The nucleic acid POCT detector according to claim 1, characterized in that: The detection device further includes a first driving mechanism, which is drivingly connected to the consumables bin and is used to drive the consumables bin to slide in and out relative to the supporting platform.

3. The nucleic acid POCT detector according to claim 1, characterized in that: The mobile robotic arm module includes a slide rail, a slider, a second drive mechanism, a third drive mechanism and a fourth drive mechanism. The slider is slidably arranged on the slide rail and is drive-connected to the second drive mechanism. The second drive mechanism is used to drive the slider to slide. The first clamp is arranged on the slider and is drive-connected to the third drive mechanism and the fourth drive mechanism respectively. The third drive mechanism is used to drive the first clamp to open and close. The fourth drive mechanism is used to drive the first clamp to rotate to open / close the cover.

4. The nucleic acid POCT detector according to claim 3, characterized in that: The sample tube accommodating position is composed of a second clamping jaw arranged on the supporting platform, and the second clamping jaw is drivingly connected to a fifth driving mechanism, and the fifth driving mechanism is used to drive the second clamping jaw to open and close.

5. The nucleic acid POCT detector according to claim 3, characterized in that: A movable light blocking member is provided at the slot opening of the detection slot, and the first clamping claw is further used for clamping or pushing the movable light blocking member and moving the movable light blocking member under the drive of the second driving mechanism.

6. The nucleic acid POCT detector according to claim 3, characterized in that: The mobile robotic arm module also includes a magnetic rod mounting block and a sixth driving mechanism. The magnetic rod is arranged on the magnetic rod mounting block. The magnetic rod mounting block can be lifted and lowered on the slider and is connected to the sixth driving mechanism. The sixth driving mechanism is used to drive the magnetic rod mounting block to perform lifting and lowering movements.

7. The nucleic acid POCT detector according to claim 3, characterized in that: The mobile robotic arm module also includes a nozzle mounting block and a seventh driving mechanism. The nozzle is arranged on the nozzle mounting block. The nozzle mounting block can be raised and lowered on the slider and is connected to the seventh driving mechanism. The seventh driving mechanism is used to drive the nozzle mounting block to perform lifting movement.

8. The nucleic acid POCT detector according to claim 1, characterized in that: The consumables bin also includes a consumables rack, which is installed on the supporting platform and is provided with a plurality of magnetic rod slots for placing the magnetic rods and a plurality of nozzle slots for placing the nozzles.

9. The nucleic acid POCT detector according to claim 1, characterized in that: The detection device also includes a heating device, which is arranged at the bottom of the reagent tank and is used to heat and amplify the sample to be tested.

10. The nucleic acid POCT detector according to any one of claims 1 to 9, characterized in that: The nucleic acid POCT detector also includes a barcode scanner, which is arranged on the supporting platform and close to the sample tube accommodating position, and is used to identify sample information of the sample tube.

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