A biomechanical properties testing system for eyeball wall tissue

Abstract

The present invention relates to a biomechanical property testing system for eyeball wall tissue, belonging to the technical field of biomechanical property testing, and solves the problem in the prior art that the measurement results of the testing system cannot truly reflect the mechanical properties of the tissue. The present invention comprises a fixed base (1), a load direction adjustment module (2), a load loading module (3), an external deformation measurement module (4), a physiological environment maintenance module (5), a sample (6), a sample adjustment module (8), a sample clamping module (9) and a load measurement module (10). The present invention adopts a physiological environment maintenance module to maintain the original geometric structure and liquid environment of the eyeball during the test, so that the mechanical properties of each layer of the eyeball wall tissue can be accurately obtained under conditions similar to in vivo conditions.

Description

Technical Field

[0001] The invention relates to the technical field of biomechanical performance testing, and in particular to a biomechanical performance testing system for eyeball wall tissue. Background Art

[0002] The eyeball is an important visual organ with a complex multi-layer structure. A deep understanding of the mechanical properties of each layer of the eyeball wall is of great significance for clarifying the mechanism of the occurrence and development of eye disease and promoting the development of new surgical methods and instruments. However, it is still a huge challenge to accurately obtain the mechanical data of each layer of the eyeball wall.

[0003] First of all, the wall of the eyeball is a multi-layered, non-uniform composite tissue composed of the sclera, choroid, and retina, with a total thickness of about 0.8 mm and the thinnest layer of about 0.15 mm. Commonly used methods for testing the mechanical properties of biological tissues are tensile method and indentation method. The tensile method is suitable for biological samples with a large elastic modulus and easy to clamp samples, and the indentation method is suitable for biological samples that are non-sticky and have a certain thickness. The traditional tensile method measures the Young's modulus of a single tissue, and there are certain difficulties in the peeling, acquisition, and clamping measurement of the test samples of each layer of the eyeball wall. The indentation method is also one of the commonly used measurement methods, and the test samples of each layer of the eyeball wall cannot meet the requirement that the sample thickness is much greater than the indentation depth. In addition, the inside of the eyeball is a liquid environment with a certain pressure, and each layer of tissue is subjected to a uniform outward expansion force. Directly peeling off the tissue for measurement cannot reflect the true mechanical properties of the tissue.

[0004] The thickness of the eyeball wall tissue is relatively thin and difficult to separate. When measuring by the tensile method, the test sample is difficult to be clamped by the fixture; when measuring by the indentation method, the test sample cannot meet the requirement that the sample thickness is much greater than the indentation depth. The existing measurement method cannot simulate the physiological environment of the tissue in the body, and the measurement data cannot truly reflect the mechanical properties of the tissue.

[0005] In order to obtain accurate and in vivo mechanical properties of each layer of tissue in the eyeball wall, the original geometric structure and liquid environment of the eyeball need to be maintained, but the measurement of tissue mechanical properties under these conditions requires solving multiple problems. First, traditional fixtures are not suitable for non-uniform spherical eyeballs; second, the stability of the physiological environment of the object being measured during the measurement will affect the accuracy of the measurement data; then, the correspondence between the multi-layer composite tissue and the mechanical properties of each layer of tissue is still unclear; finally, the deformation of the inner and outer tissues of the eyeball wall requires a non-invasive measurement method. Summary of the invention

[0006] In view of the above analysis, the present invention aims to design a biomechanical properties testing system for eyeball wall tissue to solve the problem that the measurement results of the existing testing system cannot truly reflect the mechanical properties of the tissue.

[0007] The present invention provides an eyeball wall tissue biomechanical property testing system, comprising a fixed base, a load direction adjustment module, a load loading module, an external deformation measurement module, a physiological environment maintaining module, a sample, a sample adjustment module, a sample clamping module and a load measurement module;

[0008] Wherein, the load direction adjustment module is fixedly arranged on the fixed base, the load loading module and the external deformation measurement module are fixedly arranged on the load direction adjustment module, the load direction adjustment module can adjust the positions of the load loading module and the external deformation measurement module in the three directions of length, width and height, and can adjust the deflection angle of the load loading module; the load measurement module is fixedly arranged on the load loading module;

[0009] The sample adjustment module is fixedly arranged on the fixed base, and the sample clamping module is slidably arranged on the sample adjustment module; the sample clamping module can clamp or release the sample;

[0010] The physiological environment maintaining module includes a puncture needle, a liquid pipeline and a liquid container; the diameter of the liquid container is larger than the diameter of the liquid pipeline; the liquid container is filled with artificial aqueous humor; the puncture needle can pierce the sample, and the artificial aqueous humor flows from the liquid container through the liquid pipeline and the puncture needle into the sample and maintains the hydraulic environment inside the sample.

[0011] Furthermore, it also includes an internal deformation measurement module, which includes an optical channel and an optical coherence tomography scanner; the optical channel is vertically fixed to the upper end of the sample, and the optical coherence tomography scanner can measure the deformation inside the sample through the optical channel.

[0012] Furthermore, the sample clamping module includes a clamping module support, a middle limit block, a bottom limit block, a screw-in screw, an upper arm, a lower arm and a sample clamp; the clamping module support is slidably arranged on the sample adjustment module, the middle limit block is fixedly arranged on the clamping module support, and the bottom limit block is arranged below the middle limit block; the upper arm is divided into an upper section, a middle section and a lower section, the turning point between the middle section and the lower section of the upper arm is hinged to the middle limit block, the bottom of the lower section of the upper arm is hinged to the upper end of the lower arm, and the lower end of the lower arm is hinged to the bottom limit block.

[0013] Furthermore, the sample clamp is arranged at the top of the upper section of the upper arm; the screw-in screw is screwed to the threaded through hole in the middle of the middle limit block and passes through the through hole in the middle of the bottom limit block; a nut is arranged on the screw-in screw, and the nut abuts against the bottom surface of the bottom limit block.

[0014] Furthermore, the sample clamping module further comprises a sample platform, which is fixedly arranged at the top end of the screw-in screw and located above the middle limit block, and the upper surface of the sample platform is a spherical concave surface.

[0015] Furthermore, the upper arm, the lower arm and the sample clamping jaws are provided in four groups and are evenly distributed along the circumference of the middle limit block. The four sample clamping jaws can simulate the clamping action of the four extraocular rectus muscles on the eyeball.

[0016] Furthermore, the upper arm is a rod, and its center line is a broken line.

[0017] Further, along the vertical upward direction, the lower section extends obliquely toward the direction close to the center of the middle limit block, the middle section extends toward the direction away from the middle limit block, and the upper section extends toward the direction close to the center of the middle limit block.

[0018] Furthermore, the sample clamp has a clamping portion and a mounting portion protruding outward from the clamping portion, and the mounting portion is rotatably connected to the upper arm.

[0019] Furthermore, the clamping surface of the clamping portion is a spherical concave surface, and the diameter of the spherical concave surface is less than or equal to the diameter of the eyeball.

[0020] Compared with the prior art, the present invention can achieve at least one of the following beneficial effects:

[0021] (1) The test system of the present invention achieves the function of maintaining constant intraocular pressure by setting up a physiological environment maintenance module to inject a constant pressure aqueous humor solution into the eyeball, thereby maintaining the original geometric structure and liquid environment of the eyeball during the test, thereby accurately obtaining the mechanical properties of each layer of the eyeball wall tissue under in vivo conditions. By ensuring the stability of the liquid environment inside the eyeball, the accuracy of the data is improved.

[0022] (2) The load direction adjustment module of the present invention realizes the function of adjusting the three directions of X, Y, and Z (i.e., length, width, and height) and the deflection angle through multiple slide rail structures. The load application module realizes the function of applying an adjustable load through a driving motor. The load measurement module realizes the function of measuring mechanical parameters through a series connection of mechanical probes and mechanical sensors.

[0023] (3) The sample clamping module of the present invention has a specific structural design. By adjusting the screw rod, the upper arm and the lower arm move, thereby changing the distance between the clamping claw and the sample platform and the center point, so as to achieve the function of clamping and fixing eyeballs of different sizes. For spherical samples, the sample clamping module can be adjusted according to the sample size. The original anatomical structure of the eyeball can be maintained, reducing the difficulty of sample sampling.

[0024] (4) The test system of the present invention includes an internal deformation measurement module and an external deformation measurement module. The internal deformation measurement module records the internal deformation through optical coherence tomography. The light is redirected through the optical pathway and enters the interior of the eyeball from the cornea, thereby non-invasively measuring the internal and external deformation data of the sample.

[0025] In the present invention, the above-mentioned technical solutions can also be combined with each other to achieve more preferred combination solutions. Other features and advantages of the present invention will be described in the subsequent description, and some advantages can become obvious from the description, or can be understood by practicing the present invention. The purpose and other advantages of the present invention can be realized and obtained through the contents particularly pointed out in the description and the drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings are only used for the purpose of illustrating specific embodiments and are not to be considered as limiting the present invention. In the entire drawings, the same reference symbols represent the same components;

[0027] Figure 1 It is a structural schematic diagram of the eyeball wall tissue biomechanical properties testing system of the present invention;

[0028] Figure 2 It is a structural schematic diagram of a load direction adjustment module of the present invention;

[0029] Figure 3 It is a structural schematic diagram of a load loading module of the present invention;

[0030] Figure 4 It is a structural schematic diagram of the external deformation measurement module of the present invention;

[0031] Figure 5 It is a structural schematic diagram of the physiological environment maintaining module of the present invention;

[0032] Figure 6 It is a structural schematic diagram of the internal deformation measurement module of the present invention;

[0033] Figure 7 It is a structural schematic diagram of the sample adjustment module of the present invention;

[0034] Figure 8 It is a structural schematic diagram of the sample clamping module of the present invention;

[0035] Fig. 9 is an exploded schematic diagram of the sample clamping module of the present invention;

[0036] Fig.10 It is a structural schematic diagram of the load measurement module of the present invention.

[0037] Reference numerals:

[0038] 1-Fixed base; 2-Load direction adjustment module; 201-X direction adjustment knob; 202-X direction fixed knob; 203-X direction adjustment platform; 204-Y direction adjustment knob; 205-Y direction fixed knob; 206-Y direction adjustment platform; 207-Z direction adjustment knob; 208-Z direction fixed knob; 209-Z direction adjustment platform; 210-Deflection angle adjustment knob; 211-Deflection angle fixed knob; 212-Load deflection angle adjustment platform; 213-Module installation platform; 3-Load loading module; 301-Drive motor; 302-Motor fixture 1; 303-Motor fixture 2; 4-External deformation measurement module; 401-Camera arm; 402-Camera support mounting hole; 403-Camera support; 404-Camera arm mounting hole; 405-Camera; 406-Camera Installation hole; 5-physiological environment maintenance module; 501-puncture needle; 502-liquid pipeline; 503-liquid container; 6-sample; 7-internal deformation measurement module; 701-optical channel; 702-optical coherence tomography scanner; 8-sample adjustment module; 801-bracket hole; 802-adjustment bracket; 803-sample adjustment knob; 804-sample fixing knob; 805-slider; 806-slide rail; 9-sample clamping module; 901-clamping module support; 902-sample clamping jaw; 903-bolt; 904-sample platform; 905-upper arm; 906-middle limit block; 907-lower arm; 908-bottom limit block; 909-screw-in screw; 10-load measurement module; 1001-mechanical probe; 1002-force sensor; 1003-sensor fixing bolt; 1004-mechanical data interface. DETAILED DESCRIPTION

[0039] The preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, wherein the accompanying drawings constitute a part of the present invention and are used together with the embodiments of the present invention to illustrate the principles of the present invention, but are not used to limit the scope of the present invention.

[0040] Example 1

[0041] A specific embodiment of the present invention, as Figure 1 As shown, a system for testing the biomechanical properties of eyeball wall tissue is disclosed, including a fixed base 1, a load direction adjustment module 2, a load loading module 3, an external deformation measurement module 4, a physiological environment maintaining module 5, a sample 6, an internal deformation measurement module 7, a sample adjustment module 8, a sample clamping module 9 and a load measurement module 10, and the corresponding modules can be installed or uninstalled according to actual use needs.

[0042] The fixed base 1 is a rigid metal platform having mounting holes for each module.

[0043] The structure of the load direction adjustment module 2 is as follows: Figure 2 As shown, the X-direction adjustment platform 203 is installed and fixed above the fixed base 1, and the X-direction adjustment knob 201 and the X-direction fixed knob 202 are fixed on the X-direction adjustment platform 203, so that the load can be adjusted horizontally in the X direction. The Y-direction adjustment platform 206 is installed and fixed above the X-direction adjustment platform 203, and the Y-direction adjustment knob 204 and the Y-direction fixed knob 205 are fixed on the Y-direction adjustment platform 206, so that the load can be adjusted horizontally in the Y direction. The Z-direction adjustment platform 209 is installed and fixed above the Y-direction adjustment platform 206, and the Z-direction adjustment knob 207 and the Z-direction fixed knob 208 are fixed on the Z-direction adjustment platform 209, so that the load can be adjusted horizontally in the Z direction. The load deflection angle adjustment platform 212 is installed and fixed above the Z-direction adjustment platform 209, and the deflection angle adjustment knob 210, the deflection angle fixed knob 211 and the module installation platform 213 are fixed on the load deflection angle adjustment platform 212, so that the load deflection angle can be adjusted. The load direction adjustment module 2 can adjust the X, Y, and Z directions and the deflection angle of the load loading module 3 and the external deformation measurement module 4. The X direction is the length direction, the Y direction is the width direction, and the Z direction is the height direction.

[0044] The structure of load loading module 3 is as follows Figure 3 As shown, it includes a driving motor 301, a motor fixture 1 302 and a motor fixture 2 303, which are installed and fixed on the load deflection angle adjustment platform 212. The motor fixture 1 302 and the motor fixture 2 303 clamp and fix the driving motor 301 on the module installation platform 213. The load parameters are transmitted through the load data interface 304.

[0045] The structure of the external deformation measurement module 4 is as follows: Figure 4 As shown, it includes a camera arm 401, a camera support 403 and a camera 405. The camera 405 is installed at a camera mounting hole 406 on the camera arm 401, the camera 405 faces the sample 6, the camera arm 401 is installed at a camera arm mounting hole 404 on the camera support 403, the distance between the camera 405 and the sample 6 can be adjusted by rotating the camera arm 401, and the camera support 403 is fixed to the module mounting platform 213 through the camera support mounting hole 402.

[0046] The structure of the physiological environment maintenance module 5 is as follows Figure 5 As shown, it includes a puncture needle 501, a liquid pipeline 502 and a liquid container 503. Among them, the diameter of the liquid container 503 needs to be much larger than the liquid pipeline 502. The puncture needle 501 pierces the sample 6, and the artificial aqueous humor flows from the liquid container 503 through the liquid pipeline 502 and the puncture needle 501 into the sample 6. According to the liquid pressure calculation formula, the liquid perfusion pressure can be changed by adjusting the height of the liquid pipeline 502 and the liquid container 503.

[0047] Among them, the composition of artificial aqueous humor tries to simulate the composition of natural aqueous humor to ensure its physiological function and stability in the eyeball. Natural aqueous humor is mainly composed of special ingredients such as water, electrolytes, trace proteins, sugars, amino acids, ascorbic acid, hyaluronic acid, etc. Therefore, artificial aqueous humor also contains these key ingredients, but the specific proportion and concentration need to be adjusted according to actual application.

[0048] The physiological environment maintaining module 5 can be fixedly disposed on the fixed base 1 , so that the liquid container 503 is located obliquely above the sample 6 , preferably in a direction opposite to the direction of the load loading module 3 .

[0049] In a preferred embodiment, a liquid level sensing element is provided in the liquid container 503, which can detect the depth of the liquid in the liquid container 503 in real time, thereby ensuring that the original liquid environment inside the eyeball is maintained during the entire experiment, thereby improving the accuracy of the measurement data.

[0050] The sample 6 is mainly an eyeball sample. To test other biological samples, other sample clamping modules 9 need to be replaced.

[0051] The structure of the internal deformation measurement module 7 is as follows: Figure 6 As shown, it includes an optical channel 701 and an optical coherence tomography scanner 702. The optical coherence tomography scanner 702 measures the deformation inside the sample 6 through the optical channel 701, and the optical channel 701 is vertically fixed to the upper end of the sample 6.

[0052] The structure of the sample adjustment module 8 is as follows: Figure 7 As shown, the adjustment bracket 802 is installed and fixed above the fixed base 1 through the bracket hole 801. By rotating the sample adjustment knob 803 and the sample fixing knob 804, the slider 805 can slide up and down along the slide rail 806, thereby adjusting the distance between the sample and the end of the optical channel 701 to obtain the best imaging effect.

[0053] The structure of the sample clamping module 9 is as follows: Figure 8 , Fig. 9 As shown, it includes a clamping module support 901, a sample clamping claw 902, a bolt 903, a sample platform 904, an upper arm 905, a middle limit block 906, a lower arm 907, a bottom limit block 908 and a screw-in screw 909.

[0054] The main body of the clamping module support 901 is a plate-shaped member, on which a plurality of first mounting holes are arranged, and a mounting platform protruding from the plate-shaped plane, on which a second mounting hole is arranged. The clamping module support 901 is fixed to the slider 805 through the first mounting hole, and can move up and down with the slider 805.

[0055] The central position of the middle stop block 906 has a threaded through hole for the screw rod 909 to pass through. Four groups of mounting lugs protrude outward from the side of the middle stop block 906, and the four groups of mounting lugs are evenly distributed along the circumference of the middle stop block 906. Each group of mounting lugs includes two parallel mounting lugs, and a through hole is provided in the middle of each mounting lug.

[0056] A mounting boss is also provided on the side of the middle limit block 906, and the mounting boss is located between the two sets of mounting lugs. A through hole is provided on the mounting boss, and the middle limit block 906 is connected to the clamping module support 901 through the through hole.

[0057] The bottom stop block 908 is a square block, which is arranged parallel to the middle stop block 906. The middle of the bottom stop block 908 is a through hole, the diameter of which is slightly larger than the screw 909. Each side of the bottom stop block 908 protrudes outwardly with a mounting lug, and each mounting lug is provided with a through hole.

[0058] The lower arm 907 is a connecting rod, one end of which is rotatably connected to the bottom limit block 908 through a pivot and the through hole, and the other end of which is rotatably connected to the lower end of the upper arm 905 through a pivot.

[0059] The upper arm 905 is a rod, and its center line is a broken line, which is divided into an upper section, a middle section, and a lower section. The upper arm 905 is provided with three through holes, which are respectively located at the top of the upper section, the bottom of the lower section, and the turning point between the lower section and the middle section. Along the vertical upward direction, the lower section extends obliquely toward the direction close to the center of the middle limit block 906, the middle section extends toward the direction away from the middle limit block 906, and the upper section extends toward the direction close to the center of the middle limit block 906.

[0060] The bottom end of the lower end of the upper arm 905 is rotatably connected to the lower arm 907, the turning point of the lower section and the middle section is rotatably connected to the mounting lug of the middle limit block 906, and the top of the upper section is rotatably connected to the sample clamp 902 through the bolt 903. Through such a setting, the sample clamp 902 can adaptively fit the surface of the sample 6. Through the movement of the upper arm 905, the four sample clamps 902 can simulate the clamping action of the four extraocular rectus muscles on the eyeball.

[0061] The sample clamp 902 has a clamping portion and a mounting portion protruding outward from the clamping portion, and a through hole is provided on the mounting portion, which can be connected to the upper arm 905 by a bolt 903. The clamping surface of the clamping portion is a spherical concave surface. The diameter of the spherical concave surface is less than or equal to the diameter of the eyeball. Furthermore, in order to increase the friction force, a plurality of horizontal grooves are provided on the clamping surface. The relative position of the center of the concave surface of the sample clamp 902 and the center of the sample 6 can be adjusted by a matching bolt 903 for stable clamping.

[0062] Preferably, in order to avoid measurement errors caused by deformation of the clamping surface, the clamping surface is made of a rigid material.

[0063] The screw-in screw 909 includes a nut and a screw, the diameter of the nut is larger than the diameter of the middle through hole of the bottom stop block 908, and the size of the screw matches the size of the threaded through hole at the center of the middle stop block 906. The screw-in screw 909 penetrates the middle through hole of the bottom stop block 908 and is screwed into the threaded through hole at the center of the middle stop block 906.

[0064] By rotating and screwing in the screw rod 909, the distance between the bottom limit block 908 and the middle limit block 906 can be adjusted. When the distance is reduced, the sample clamping jaws 902 located at the top of the upper section of the upper arm 905 are close to each other to clamp the sample 6; when the distance is increased, the sample clamping jaws 902 are away from each other to release the sample 6.

[0065] Furthermore, in order to improve the accuracy of positioning the sample 6, a sample platform 904 is provided on the top of the screw-in screw 909. A spherical groove is provided on the top of the sample platform 904 to make the sample 6 more stable and keep the pupil in a vertical direction, which is convenient for the measurement of the internal deformation measurement module 7. In this solution, the screw-in screw 909 is inserted into the threaded through hole from above the middle stop block 906, then passes through the middle through hole of the bottom stop block 908, and finally a nut is screwed on the end of the screw-in screw 909.

[0066] With this arrangement, when the screw rod 909 is rotated, the sample clamping jaws 902 are adjusted to move closer to or farther from each other, and the sample platform 904 can also be adjusted to move toward or away from the enclosed center of the sample clamping jaws 902 at the same time.

[0067] The screw rod 909 is rotated upward, the sample platform 904 moves upward, the bottom limit block 908 moves upward to drive the upper arm 905 and the lower arm 907 to move, the clamping jaw 902 moves toward the center, and the sample clamping jaw 902 and the sample platform 904 cooperate with each other to fix the sample 6.

[0068] The load measurement module 10 is as follows Fig.10 As shown, the mechanical probe 1001 is installed at the front end of the force sensor 1002, and the force sensor 1002 is installed on the load loading module 3 through the sensor fixing bolt 1003. The load loading module 3 pushes the load measurement module 10 to move forward, applies load to the sample 6, and the measured mechanical parameters are transmitted through the mechanical data interface 1004.

[0069] Sample 6 is usually an eyeball sample, and this example is explained using the eyeball sample.

[0070] The sample 6 is placed vertically on the sample platform 904, with the cornea facing vertically upward. The screw 909 is rotated upward to screw in. The sample platform 904 moves upward, and the bottom limit block 908 moves upward to drive the lower arm 907 and the upper arm 905 to move. The clamp 902 moves toward the center. The sample clamp 902 and the sample platform 904 cooperate with each other to fix the sample 6. It is necessary to ensure that the sample is firmly clamped and does not deform significantly. Install a suitable mechanical probe 1001, and adjust the load application direction to be in the same horizontal plane with the center of the sample 6 through the load direction adjustment module 2 and the sample adjustment module 8. The load application angle can be adjusted according to needs. Adjust the distance and angle between the camera 405 and the sample 6 to ensure that the load application process can be fully recorded. The puncture needle 501 penetrates the sclera of the sample 6 from the opposite direction of the load application to avoid affecting the load application process. Adjust the height of the liquid pipeline 502 and the liquid container 503 to ensure that the internal liquid pressure of the sample 6 is maintained at 15mmHg, and adjust the distance between the end of the optical channel 701 and the sample 6 to ensure clear imaging. The load data interface 304 sends a command to start the mechanical test, the load data interface 304 receives the displacement data, the mechanical data interface 1004 receives the force data, and the external deformation measurement module 4 and the internal deformation measurement module 7 record and measure the sample deformation data.

[0071] Compared with the prior art, the system provided in this embodiment can perform biomechanical performance testing while maintaining the original anatomical structure and physiological environment of the eyeball. By applying a load force with adjustable size and direction through the system, the corresponding deformation data of the eyeball wall tissue under this condition can be obtained, and the mechanical parameters such as the Young's modulus of the corresponding tissue can be determined based on finite element analysis and computational mechanics.

[0072] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by any technician familiar with the technical field within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention.

Claims

1. A system for testing the biomechanical properties of eyeball wall tissue, characterized in that: It comprises a fixed base (1), a load direction adjustment module (2), a load loading module (3), an external deformation measurement module (4), a physiological environment maintenance module (5), a sample (6), a sample adjustment module (8), a sample clamping module (9) and a load measurement module (10); The load direction adjustment module (2) is fixedly arranged on the fixed base (1), the load loading module (3) and the external deformation measurement module (4) are fixedly arranged on the load direction adjustment module (2), and the load direction adjustment module (2) is capable of adjusting the positions of the load loading module (3) and the external deformation measurement module (4) in three directions of length, width and height, and is capable of adjusting the deflection angle of the load loading module (3); the load measurement module (10) is fixedly arranged on the load loading module (3); The sample adjustment module (8) is fixedly arranged on the fixed base (1), and the sample clamping module (9) is slidably arranged on the sample adjustment module (8) up and down; the sample clamping module (9) is capable of clamping or releasing the sample (6); The physiological environment maintaining module (5) comprises a puncture needle (501), a liquid pipeline (502) and a liquid container (503); the diameter of the liquid container (503) is larger than the diameter of the liquid pipeline (502); the liquid container (503) is filled with artificial aqueous humor; the puncture needle (501) is capable of piercing the sample (6); the artificial aqueous humor flows from the liquid container (503) through the liquid pipeline (502) and the puncture needle (501) into the sample (6) and maintains the hydraulic environment inside the sample (6).

2. The eyeball wall tissue biomechanical properties testing system according to claim 1, characterized in that: The invention also comprises an internal deformation measurement module (7), wherein the internal deformation measurement module (7) comprises an optical channel (701) and an optical coherence tomography scanner (702); the optical channel (701) is vertically fixed to the upper end of the sample (6), and the optical coherence tomography scanner (702) is capable of measuring the deformation inside the sample (6) through the optical channel (701).

3. The eyeball wall tissue biomechanical properties testing system according to claim 2, characterized in that: The sample clamping module (9) comprises a clamping module support (901), a middle limit block (906), a bottom limit block (908), a screw-in screw (909), an upper arm (905), a lower arm (907) and a sample clamping claw (902); the clamping module support (901) is slidably arranged on the sample adjustment module (8), and the middle limit block (906) is fixedly arranged on the clamping module support (901). The bottom limit block (908) is arranged below the middle limit block (906); the upper arm (905) is divided into an upper section, a middle section and a lower section; the turning point between the middle section and the lower section of the upper arm (905) is hinged to the middle limit block (906); the bottom of the lower section of the upper arm (905) is hinged to the upper end of the lower arm (907); and the lower end of the lower arm (907) is hinged to the bottom limit block (908).

4. The eyeball wall tissue biomechanical properties testing system according to claim 3, characterized in that: The sample clamping jaw (902) is arranged at the top of the upper section of the upper arm (905); the screw-in screw rod (909) is screwed to the threaded through hole in the middle of the middle limit block (906) and passes through the through hole in the middle of the bottom limit block (908); a nut is arranged on the screw-in screw rod (909), and the nut abuts against the bottom surface of the bottom limit block (908).

5. The eyeball wall tissue biomechanical properties testing system according to claim 4, characterized in that: The sample clamping module (9) further comprises a sample platform (904), wherein the sample platform (904) is fixedly arranged at the top end of the screw-in screw (909) and is located above the middle stop block (906), and the upper surface of the sample platform (904) is a spherical concave surface.

6. The eyeball wall tissue biomechanical properties testing system according to any one of claims 3 to 5, characterized in that: The upper arm (905), the lower arm (907) and the sample clamping jaws (902) are provided in four groups and are evenly distributed along the circumference of the middle limit block (906). The four sample clamping jaws (902) can simulate the clamping action of the four extraocular rectus muscles on the eyeball.

7. The eyeball wall tissue biomechanical properties testing system according to claim 6, characterized in that: The upper arm (905) is a rod, and its center line is in the shape of a broken line.

8. The eyeball wall tissue biomechanical properties testing system according to claim 7, characterized in that: Along the vertical upward direction, the lower section extends obliquely toward the center of the middle limit block (906), the middle section extends toward a direction away from the middle limit block (906), and the upper section extends toward the center of the middle limit block (906).

9. The eyeball wall tissue biomechanical properties testing system according to claim 8, characterized in that: The sample clamping claw (902) comprises a clamping portion and a mounting portion protruding outward from the clamping portion, and the mounting portion is rotatably connected to the upper arm (905).

10. The eyeball wall tissue biomechanical properties testing system according to claim 9, characterized in that: The clamping surface of the clamping portion is a spherical concave surface, and the diameter of the spherical concave surface is less than or equal to the diameter of the eyeball.

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