An alcohol disinfectant solution with a color-changing indication function and a preparation method

Abstract

The present invention discloses an alcohol disinfectant solution with a color-changing indication function and a preparation method, belonging to the technical field of disinfectant solutions, which is characterized by being composed of the following components in parts by weight: 0.1-0.3% (w / v) reducing agent, 0.05-0.07 mol / L indicator, 0.08-0.12% (w / v) reaction assistant, 1.6-1.8% (w / v) skin care agent, 70% (v / v) ethanol, and the solvent is water; The beneficial effects of the present invention are: 1. The bactericidal effect of the disinfectant solution prepared by using basic safranine, glucose, and fatty alcohol polyoxyethylene ether in the alcohol disinfectant solution is not affected; 2. The initial liquid is colorless and transparent, turns red after reacting with oxygen in the air, and turns colorless again after a period of time; 3. During the change process of the disinfectant solution from colorless to red to colorless, the color-changing time can be controlled by adjusting the ratio of the disinfectant solution, so that the disinfectant solution of the present invention has a better flexible application effect.

Description

Technical Field:

[0001] The present invention belongs to the technical field of disinfectant solutions, and more specifically relates to an alcohol disinfectant solution with a color-changing indication function and a preparation method therefor. Background Art:

[0002] In the field of medical infection control, alcohol disinfectants are commonly used skin disinfectant products. Skin disinfectants should have the characteristics of quick drying, broad-spectrum bactericidal activity, non-irritation, skin care, etc., and medical staff need to operate strictly in accordance with the norms. When using disinfection products for skin disinfection, there is a problem that it is impossible to judge whether medical staff strictly meet the disinfection operation standards, and the disinfection solution cannot be visually monitored. Therefore, it is necessary to develop a disinfection solution with a color-changing indication function that can monitor whether the disinfection process meets the standard requirements. Summary of the Invention:

[0003] To solve the above problems and overcome the deficiencies of the prior art, the present invention provides a skin disinfectant solution with a color-changing indication function and a preparation method therefor. The present invention can be well applied to the skin disinfection process of medical staff, and the standardization of disinfection operations can be judged by color changes, aiming to develop the visual function characteristics of disinfection. The prepared disinfection solution can change color in the air, and the time of the color change process can be controlled by adjusting the raw material ratio of the disinfection solution. At the same time, it has good broad-spectrum bactericidal ability, and has the advantages of strong operability and strong indication effect, and can be applied to the field of medical infection control.

[0004] The specific technical solution of the present invention to solve the above technical problems is: an alcohol disinfectant solution with a color-changing indication function, which is characterized by being composed of the following components in parts by weight: 0.1-0.3% (w / v) reducing agent, 0.05-0.07 mol / L indicator, 0.08-0.12% (w / v) reaction assistant, 1.6-1.8% (w / v) skin care agent, 70% (v / v) ethanol, and the solvent is water;

[0005] The reducing agent is glucose; the indicator is basic safranine; the reaction assistant is fatty alcohol polyoxyethylene ether.

[0006] Further, the skin care agent is glycerol or allantoin or a mixture of the two.

[0007] Further, the alcohol disinfectant solution can have a bactericidal effect on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa or Candida albicans.

[0008] Further, the color of the alcohol disinfectant solution is colorless, and the time for changing from colorless to red after contacting with oxygen in the air is 25 s - 2 min, and the fading time from red to colorless is 55 s - 5 min.

[0009] A preparation method of an alcohol disinfectant solution with a color-changing indication function, characterized in that the alcohol disinfectant solution is prepared; the method includes the following steps:

[0010] (1) Mix and dilute a reducing agent and deionized water in a certain proportion.

[0011] (2) Under the condition of nitrogen protection, take an indicator and fully stir and mix it with the above-mentioned mixed solution.

[0012] (3) Under the condition of nitrogen protection, successively add ethanol, a skin care agent, and a reaction auxiliary agent to the above-mentioned mixed solution. After fully stirring and mixing, the disinfectant solution with the color-changing indication function is obtained.

[0013] Furthermore, it includes the following steps:

[0014] (1) Mix and dilute a glucose solution with a mass concentration of 20% (w / v) and deionized water according to a mass ratio of 1:67.7 - 200.

[0015] (2) Under the condition of nitrogen protection, take 0.05 - 0.07 parts by weight of a 1 mol / L basic safranine solution and fully stir and mix it with the above-mentioned mixed solution.

[0016] (3) Under the condition of nitrogen protection, successively add 70% (v / v) ethanol, 0.08 - 1.0% (w / v) glycerol, 0.08 - 1.0% (w / v) allantoin, and 0.08 - 0.12% (w / v) fatty alcohol polyoxyethylene ether to the above-mentioned mixed solution. After fully stirring and mixing, the disinfectant solution with the color-changing indication function is obtained.

[0017] A use of an alcohol disinfectant solution with a color-changing indication function. Using the alcohol disinfectant solution, the alcohol disinfectant solution is applied in the process of skin hygiene disinfection. After the alcohol disinfectant solution contacts the air for a period of time, the color change process is from colorless - red - colorless, and the time requirement for the disinfection operation process of medical staff is visually indicated through the color change of the alcohol disinfectant solution.

[0018] The beneficial effects of the present invention are:

[0019] The disinfectant solution prepared by the present invention has the following advantages: 1. The bactericidal effect of the disinfectant solution prepared by using basic safranine, glucose, and fatty alcohol polyoxyethylene ether in the alcohol disinfectant solution is not affected; 2. The initial liquid is colorless and transparent, turns red after reacting with oxygen in the air, and turns colorless again after a period of time; 3. During the color change process of the disinfectant solution from colorless - red - colorless, the color change time can be controlled by adjusting the ratio of the disinfectant solution, so that the disinfectant solution of the present invention has a good flexible application effect.

[0020] The disinfectant solution prepared by the present invention has a color-changing indication principle that under the action of the reaction auxiliary fatty alcohol polyoxyethylene ether, basic safranine undergoes a redox reaction with oxygen in the air to cause a color change, and then is reduced by glucose to be colorless, thereby causing the disinfectant solution to change color; fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant solution exhibit more stable physical and chemical properties, but also can realize the controllable adjustment of the color-changing cycle, so as to meet the need of visual indication for the time requirement of the disinfection operation process of medical staff through the color change of the alcohol disinfectant solution;

[0021] Compared with the prior art, the present invention has relatively remarkable application effects: when the alcohol disinfectant solution is applied to the skin hygiene disinfection process, after the alcohol disinfectant solution contacts the air for a period of time, the color change process is from colorless - red - colorless, and the time node requirements of the disinfection operation process of medical staff are visually indicated through the color change of the alcohol disinfectant solution. Brief Description of the Drawings:

[0022] Attached Figure 1 is the color change process diagram of the alcohol disinfectant solution in Example 1 of the present invention;

[0023] Attached Figure 2 is the color change process diagram of the alcohol disinfectant solution in Example 2 of the present invention;

[0024] Attached Figure 3 is the color change process diagram of the alcohol disinfectant solution in Example 3 of the present invention;

[0025] Attached Figure 4 is the color change process diagram of the alcohol disinfectant solution in Example 4 of the present invention;

[0026] Attached Figure 5 is the color change process diagram of the alcohol disinfectant solution in Example 5 of the present invention;

[0027] Attached Figure 6 is the color development process diagram of the alcohol disinfectant solution in Comparative Example 1 of the present invention;

[0028] Attached Figure 7 is the color development process diagram of the alcohol disinfectant solution in Comparative Example 2 of the present invention;

[0029] Attached Figure 8 is the color change process diagram of the alcohol disinfectant solution in Comparative Example 3 of the present invention;

[0030] Attached Figure 9 is the usage state diagram of the alcohol disinfectant solution with the color-changing indication function of the present invention; Detailed Embodiments:

[0031] In the description of the present invention, specific details are only for fully understanding the embodiments of the present invention. However, those skilled in the art should know that the implementation of the present invention is not limited to these details. Additionally, well-known structures and functions are not described or shown in detail to avoid obscuring the key points of the embodiments of the present invention. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0032] Specific embodiments of the present invention:

[0033] For better understanding of the present invention, specific embodiments are used for illustration. It is emphasized that the effects of this embodiment have no substantial differences from various embodiments within the protection scope of the present invention, including their respective reagents and the content ratios of the reagents, and can all achieve the effects described in the present invention and solve the above problems. Other combinations are not elaborated here;

[0034] Example 1: By weight, the preparation method includes the following steps:

[0035] 0.1% (w / v) glucose, 0.05 mol / L basic safranin, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0036] Take a glucose solution with a mass concentration of 20% (w / v) and mix and dilute it with deionized water according to a mass ratio of 1:200; under the condition of nitrogen protection, take 0.05 part by weight of a 1 mol / L basic safranin solution; fully stir and mix it with the above mixed solution; under the condition of nitrogen protection, sequentially add 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether to the above mixed solution. After fully stirring and mixing, the disinfectant with the function of fading indication is obtained.

[0037] The disinfectant prepared in Example 1 is placed in a test tube and contacted with oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature is 2 min; the time for it to change from red to colorless is 5 min, as Figure 1 ;

[0038] Example 2: By weight, the preparation method includes the following steps:

[0039] 0.2% (w / v) glucose, 0.06 mol / L basic safranin, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.10% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0040] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water and mix and dilute them according to a mass ratio of 1:100; under the condition of nitrogen protection, take 0.06 parts by weight of a 1 mol / L safranine O solution and fully stir and mix it with the above-mentioned mixed solution; under the condition of nitrogen protection, sequentially add 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.10% (w / v) fatty alcohol polyoxyethylene ether to the above-mentioned mixed solution. After fully stirring and mixing, the disinfectant with fading indication function is obtained.

[0041] The disinfectant prepared in Example 2 was placed in a test tube and contacted with oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 1 min; the time for it to change from red to colorless was 3 min, as Figure 2 ;

[0042] Example 3: By weight, the preparation method includes the following steps:

[0043] 0.3% (w / v) glucose, 0.06 mol / L safranine O, 70% (v / v) ethanol, 0.8% (w / v) glycerol, 0.8% (w / v) allantoin, 0.12% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0044] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water and mix and dilute them according to a mass ratio of 1:66.7; under the condition of nitrogen protection, take 0.06 parts by weight of a 1 mol / L safranine O solution and fully stir and mix it with the above-mentioned mixed solution; under the condition of nitrogen protection, sequentially add 70% (v / v) ethanol, 0.8% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.12% (w / v) fatty alcohol polyoxyethylene ether to the above-mentioned mixed solution. After fully stirring and mixing, the disinfectant with fading indication function is obtained.

[0045] The disinfectant prepared in Example 3 was placed in a test tube and contacted with oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 30 s; the time for it to change from red to colorless was 1 min, as Figure 3 ;

[0046] Example 4: By weight, the preparation method includes the following steps:

[0047] 0.1% (w / v) glucose, 0.06 mol / L safranine O, 70% (v / v) ethanol, 0.8% (w / v) glycerol, 1.0% (w / v) allantoin, 0.09% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0048] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water and mix and dilute them according to a mass ratio of 1:200; under the condition of nitrogen protection, take 0.06 parts by weight of a 1 mol / L safranine O solution and fully stir and mix it with the above-mentioned mixed solution; under the condition of nitrogen protection, sequentially add 70% (v / v) ethanol, 0.8% (w / v) glycerol, 1.0% (w / v) allantoin, and 0.09% (w / v) fatty alcohol polyoxyethylene ether to the above-mentioned mixed solution, and after fully stirring and mixing, obtain the hand disinfectant with a fading indication function.

[0049] The hand disinfectant prepared in Example 4 was placed in a test tube and contacted with oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 45 s; the time for it to change from red to colorless was 2.5 min, as Figure 4 ;

[0050] Example 5: By weight, the preparation method includes the following steps:

[0051] 0.3% (w / v) glucose, 0.07 mol / L safranine O, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.085% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0052] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water and mix and dilute them according to a mass ratio of 1:66.7; under the condition of nitrogen protection, take 0.07 parts by weight of a 1 mol / L safranine O solution and fully stir and mix it with the above-mentioned mixed solution; under the condition of nitrogen protection, sequentially add 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.085% (w / v) fatty alcohol polyoxyethylene ether to the above-mentioned mixed solution, and after fully stirring and mixing, obtain the disinfectant with a fading indication function.

[0053] The disinfectant prepared in Example 5 was placed in a test tube and contacted with oxygen in the air; the time for the disinfectant to change from colorless to red at room temperature was 25 s; the time for it to change from red to colorless was 55 s, as Figure 5 ;

[0054] The disinfectants prepared in Examples 1-5 were placed in test tubes and contacted with oxygen in the air. Since the contact area between the test tube and oxygen was limited, the disinfectant was shaken slightly to increase its interaction with oxygen, and the shaking frequency and time were fixed; the disinfectants were observed at room temperature.

[0055] Table 1: Results of color change time and bactericidal effect of different examples

[0056]

[0057] Table 2: Testing the bactericidal performance against different harmful bacteria for different embodiments

[0058]

[0059] It can be seen from the data analysis of Table 1 and Table 2 that:

[0060] (1) For the hand disinfectant solution prepared in Examples 1-5, the bactericidal performance was tested in accordance with the "Disinfection Technical Specification" (2002 Edition). Bactericidal tests were carried out on bacteria such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, and the test results all met the requirements of the "Disinfection Technical Specification" (2002 Edition) for qualified disinfection.

[0061] (2) For the disinfectant solution prepared in the present invention, its color-changing indication principle is that under the action of the reaction assistant fatty alcohol polyoxyethylene ether, basic safranine undergoes an oxidation-reduction reaction with oxygen in the air to cause a color change, and then is reduced to colorless by glucose, resulting in the color change of the disinfectant solution; fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant solution show more stable physical and chemical properties, but also can realize the controllable adjustment of the color-changing cycle. In particular, the fading time from red to colorless is 55S - 5 minutes, which can meet the need for visual indication of the time requirements for the disinfection operation process of medical staff through the color change of the alcohol disinfectant solution; the time node requirements for the disinfection operation process of medical staff are visually indicated through the color change of the alcohol disinfectant solution.

[0062] In order to more intuitively demonstrate the process advantages of the present invention, the alcohol disinfectant solution with a color-changing indication function of the present invention and the same process using the method of equivalent substitution were compared.

[0063] Comparative Example 1: The preparation method is the same as that of the example. The difference is that: during the preparation process of this comparative example, the indicator is replaced with: methyl red, methylene red, bromocresol green, thymol blue solution;

[0064] 0.1% (w / v) glucose, 0.05 mol / L indicator, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water. The indicator includes: methyl red, methylene red, bromocresol green, thymol blue solution.

[0065] Take a glucose solution with a mass concentration of 20% (w / v) and deionized water and mix and dilute them according to a mass ratio of 1:200; under the condition of nitrogen protection, take 0.05 parts by weight of a 1 mol / L indicator solution and fully stir and mix it with the above-mentioned mixed solution; under the condition of nitrogen protection, sequentially add 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.08% (w / v) fatty alcohol polyoxyethylene ether to the above-mentioned mixed solution. After fully stirring and mixing, a disinfectant is obtained. The color of the disinfectant before and after does not change as Figure 6 . It can be seen that when the indicators are selected as methyl red, methylene red, bromocresol green, and thymol blue solutions, the color of the disinfectant will not change.

[0066] Comparative Example 2: The preparation method is the same as that of the Example, the difference is that: in the preparation process of this comparative example, the reducing agent: glucose is not added;

[0067] The preparation method of the ethanol hand disinfectant includes the following steps by weight:

[0068] 0.05 mol / L basic safranine, 70% (v / v) ethanol, 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, 0.08% (w / v) fatty alcohol polyoxyethylene ether, and the solvent is water.

[0069] Under the condition of nitrogen protection, take 0.05 parts by weight of a 1 mol / L indicator solution and add it to a 70% (v / v) ethanol solution, and sequentially add 1.0% (w / v) glycerol, 0.8% (w / v) allantoin, and 0.08% (w / v) fatty alcohol polyoxyethylene ether. After fully stirring and mixing, a disinfectant is obtained. The color change of the disinfectant before and after is as follows Figure 7 . It can be seen that when glucose is not added to the disinfectant, the color of the disinfectant will not change.

[0070] Comparative Example 3: The preparation method is the same as that of the Example, the difference is that: in the preparation process of this comparative example, the reaction auxiliary: fatty alcohol polyoxyethylene ether is not added;

[0071] The preparation method of the ethanol disinfectant includes the following steps by weight:

[0072] 0.1 - 0.3% (w / v) glucose, 0.05 - 0.07 mol / L basic safranine, 70% (v / v) ethanol, 0.8 - 1.0% (w / v) glycerol, 0.8 - 1.0% (w / v) allantoin, and the solvent is water.

[0073] A 20% (w / v) glucose solution is mixed and diluted with deionized water in a mass ratio of 1:200; under nitrogen protection, 0.05 weight parts of a 1 mol / L indicator alkaline safflower solution is added to a 70% (v / v) ethanol solution, and 1.0% (w / v) glycerol and 0.8% (w / v) allantoin are added in sequence, and the mixture is thoroughly stirred to obtain a disinfectant.

[0074] The disinfectant prepared in Comparative Examples 1-3 was placed in a test tube to contact with oxygen in the air. Since the contact area between the test tube and oxygen was limited, the test tube was slightly shaken to increase the interaction between the disinfectant and oxygen, and the shaking frequency and time were fixed; the disinfectant was observed at room temperature;

[0075] Table 3: Comparison of color development effects of different embodiments and comparative examples

[0076]

[0077] From the data analysis of Tables 1 and 3, we can see that:

[0078] (1) After the alcohol disinfectant prepared in Examples 1-5 is exposed to air for a period of time, the color changes from colorless to red to colorless. The color change of the alcohol disinfectant can provide a visual indication of the time nodes of the disinfection operation process for medical staff.

[0079] (2) Comparative Example 1 and Comparative Example 2: Both failed to achieve a fading effect, and failed to meet the need to visually indicate the time requirements of the disinfection operation process of medical personnel through the color change of the alcohol disinfectant; that is, visually indicate the time requirements of the disinfection operation process of medical personnel through the color change of the alcohol disinfectant;

[0080] (3) In Comparative Example 3, since fatty alcohol polyoxyethylene ether is not added to the disinfectant, the color change indication function of the disinfectant fails, and the solution turns yellow and cannot be restored. This cannot meet the need for visual indication of the disinfection operation time requirements of medical staff through the color change of the alcohol disinfectant, that is, visual indication of the disinfection operation time requirements of medical staff through the color change of the alcohol disinfectant;

[0081] In order to more intuitively demonstrate the process advantages of the present invention, the present invention uses an alcohol disinfectant with a color change indication function and also uses a color development effect in a simulated skin hygiene disinfection process.

[0082] Table 4: Comparison of color development effects of different embodiments and comparative examples

[0083]

[0084] As can be seen from Table 4, the alcohol disinfectant of the present invention can be applicable to different skin colors, including black, yellow or white skin colors, with an obvious color-changing effect, and can meet the time requirement of the disinfection operation process of medical staff to realize the need for visual indication;

[0085] Moreover, according to the practical results, it can be known that: by adopting the color-changing time of the color-changing effect during the simulation of the skin hygiene disinfection process and the color-changing time of the color-changing effect when the disinfectant is placed in a test tube and contacts with oxygen in the air and the color-changing time of the color-changing effect of slightly shaking the test tube to increase the interaction between the disinfectant and oxygen, and the shaking frequency and time are fixed, there is little difference, especially the fading time from red to colorless has no difference, which can meet the need for visual indication of the time requirement of the disinfection operation process of medical staff through the color change of the alcohol disinfectant, that is, to realize visual indication of the time node requirement of the disinfection operation process of medical staff through the color change of the alcohol disinfectant;

[0086] In order to more intuitively demonstrate the process advantages of the present invention, the adaptability of the color-changing time of the alcohol disinfectant with color-changing indication function of the present invention to the time node requirements of the examples and Comparative Example 3 was further studied.

[0087] Comparative Example 3-1: The preparation method is the same as that of Example 1, the difference is that: in the preparation process of this comparative example, the reaction auxiliary: fatty alcohol polyoxyethylene ether was not added;

[0088] Comparative Example 3-2: The preparation method is the same as that of Example 2, the difference is that: in the preparation process of this comparative example, the reaction auxiliary: fatty alcohol polyoxyethylene ether was not added;

[0089] Comparative Example 3-3: The preparation method is the same as that of Example 3, the difference is that: in the preparation process of this comparative example, the reaction auxiliary: fatty alcohol polyoxyethylene ether was not added;

[0090] Comparative Example 3-4: The preparation method is the same as that of Example 4, the difference is that: in the preparation process of this comparative example, the reaction auxiliary: fatty alcohol polyoxyethylene ether was not added;

[0091] Comparative Example 3-5: The preparation method is the same as that of Example 5, the difference is that: in the preparation process of this comparative example, the reaction auxiliary: fatty alcohol polyoxyethylene ether was not added;

[0092] Table 5: Comparison of color-changing effects of different examples and comparative examples

[0093]

[0094] As can be seen from Table 5: In Examples 1-5, fatty alcohol polyoxyethylene ether was creatively added. Fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant show more stable physical and chemical properties, but also can realize the controllable adjustment of the discoloration period. In particular, the fading time from red to colorless is 55S - 5min, and the controllable range of the fading time is wide, which can meet the need for visual indication of the time requirement of the disinfection operation process of medical staff through the color change of the alcohol disinfectant; realize visual indication through the requirement of the time node of the disinfection operation process of medical staff by the color change of the alcohol disinfectant.

[0095] Although Comparative Examples 1-5 obtained a color change effect of colorless - red - yellow, the color difference between yellow and skin color is small and not easy to observe. More importantly, as can be seen from the data in Table 5: Although those without adding fatty alcohol polyoxyethylene ether also obtained a color change effect of colorless - red - yellow, the fading time from red to yellow is 18S - 30S, and it cannot be increased to a greater extent even after adjustment. The fading time is short, so it cannot meet the need for visual indication of the time requirement of the disinfection operation process of medical staff through the color change of the alcohol disinfectant; realize visual indication through the requirement of the time node of the disinfection operation process of medical staff by the color change of the alcohol disinfectant.

[0096] In summary:

[0097] The disinfectant prepared by the present invention has the following advantages: 1. The bactericidal effect of the disinfectant prepared by using basic safranine, glucose, and fatty alcohol polyoxyethylene ether in the alcohol disinfectant is not affected; 2. The initial liquid is colorless and transparent, turns red after reacting with oxygen in the air, and turns colorless again after a period of time; 3. During the change process of the disinfectant from colorless - red - colorless, the discoloration time can be controlled by adjusting the ratio of the disinfectant, so that the disinfectant of the present invention has a good flexible application effect;

[0098] For the disinfectant prepared by the present invention, its color change indication principle is that under the action of the reaction assistant fatty alcohol polyoxyethylene ether, basic safranine undergoes a redox reaction with oxygen in the air to change color, and then is reduced to colorless by glucose, resulting in the color change of the disinfectant; fatty alcohol polyoxyethylene ether not only acts as a stabilizer to make the alcohol disinfectant show more stable physical and chemical properties, but also can realize the controllable adjustment of the discoloration period, so as to adapt to the need for visual indication of the time requirement of the disinfection operation process of medical staff through the color change of the alcohol disinfectant;

[0099] Compared with the prior art, the present invention has a more significant application effect: When the alcohol disinfectant is applied to the skin hygiene disinfection process, after the alcohol disinfectant contacts the air for a period of time, the color change process is from colorless - red - colorless, and realize visual indication through the requirement of the time node of the disinfection operation process of medical staff by the color change of the alcohol disinfectant.

Claims

1. A preparation method of an alcohol disinfectant solution with a color-changing indication function, characterized in that The alcohol disinfectant with color change indication function is composed of the following components in parts by weight: 0.1-0.3% w / v reducing agent, 0.05-0.07 mol / L indicator, 0.08-0.12% w / v reaction aid, 70% v / v ethanol, and the solvent is water; The reducing agent is glucose; the indicator is alkaline saffron; the reaction aid is fatty alcohol polyoxyethylene ether; The preparation method comprises the following steps: (1) Mix and dilute the reducing agent and deionized water in proportion; (2) Under nitrogen protection, take the indicator and the above mixed solution and stir them thoroughly; (3) Under nitrogen protection, ethanol, a skin care agent and a reaction aid are added to the above mixed solution in sequence, and after being fully stirred and mixed, an alcohol disinfectant having a color change indication function is obtained.

2. The preparation method of the alcohol disinfectant solution with a color-changing indication function according to claim 1, characterized in that The following steps are involved: (1) Mix and dilute a 20% w / v glucose solution with deionized water in a mass ratio of 1:66.7-1:200; (2) Under nitrogen protection, 0.05-0.07 parts by weight of 1 mol / L alkaline saffron solution was added to the above mixture and stirred thoroughly; (3) Under nitrogen protection, add 70% v / v ethanol, 0.08-1.0% w / v glycerol, 0.08-1.0% w / v allantoin, and 0.08-0.12% w / v fatty alcohol polyoxyethylene ether to the above mixed solution in sequence, and stir well to obtain an alcohol disinfectant with a color change indication function.

3. The preparation method of the alcohol disinfectant solution with a color-changing indication function according to claim 1, wherein: The alcohol disinfectant can have a bactericidal effect on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa or Candida albicans.

4. The preparation method of the alcohol disinfectant solution with a color-changing indication function according to claim 1, wherein: It also includes 1.6-1.8% w / v of a skin care agent, which is glycerin or allantoin or a mixture of the two.

5. The preparation method of the alcohol disinfectant solution with a color-changing indication function according to any one of claims 1-4, characterized in that: The alcohol disinfectant is colorless, and after contacting with oxygen in the air, it takes 25s-2min for it to change from colorless to red, and it takes 55s-5min for it to fade from red to colorless.

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