A moisturizing composition and its preparation method and application

Abstract

The present invention relates to a kind of moisturizing and nourishing composition and its preparation method and application, belong to the field of cosmetics technology.The moisturizing and nourishing composition of the present invention includes the following components in parts by mass: 4.48-5.86 parts of wetting agent, 2.236-4.612 parts of emulsifier, 0.26-0.66 parts of skin softener, 0.052-0.292 parts of thickener, 0.052-0.292 parts of antioxidant synergist, 0.01-0.22 parts of preservative, 0.168-0.568 parts of vitamin E, 0.04-0.4 parts of cinnamon oil and 30.116-30.516 parts of solvent.The present invention is a moisturizing and nourishing composition by selecting vitamin E and cinnamon oil and moisturizing agent, emulsifier, skin softener, thickener, antioxidant synergist, preservative and water, which can promote the penetration of vitamin E, and has the effect of long-lasting moisturizing, maintaining skin elasticity and repairing epidermis.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a moisturizing and nourishing composition, a preparation method and an application thereof. Background Art

[0002] Hand cream is a cosmetic product that effectively prevents dry, chapped skin and leaves it smooth and tender. Existing hand creams can feel greasy, have a short moisturizing effect, lack anti-itching and antibacterial ingredients, and cannot be used when itchy hands develop. Alternatively, the antibacterial and anti-itching effects are short-lived. Furthermore, existing hand creams use cosmetic ingredients conventionally selected by those skilled in the art, often with relatively low antioxidant levels. Furthermore, vitamin E cannot penetrate the skin well enough to provide long-lasting moisturization. Summary of the Invention

[0003] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a vitamin E composition with good permeability, antioxidant properties, and moisturizing properties, as well as a preparation method and application thereof.

[0004] To achieve the above object, the technical solution adopted by the present invention is:

[0005] In a first aspect, the present invention provides a moisturizing composition, comprising the following components in parts by mass: 4.48-5.86 parts of a moisturizing agent, 2.236-4.612 parts of an emulsifier, 0.26-0.66 parts of a skin softener, 0.052-0.292 parts of a thickener, 0.052-0.292 parts of an antioxidant synergist, 0.01-0.22 parts of a preservative, 0.168-0.568 parts of vitamin E, 0.04-0.4 parts of cinnamon oil, and 30.116-30.516 parts of a solvent.

[0006] The present invention combines vitamin E and cinnamon oil with a moisturizer, an emulsifier, a skin softener, a thickener, an antioxidant synergist, a preservative, and water to form a moisturizing and nourishing composition. This composition promotes the penetration of vitamin E, provides long-lasting moisturizing, maintains skin elasticity, and repairs the epidermis. Furthermore, the moisturizing and nourishing composition also has excellent antioxidant properties and can be used to prepare a hand cream, providing long-lasting moisturizing and antioxidant benefits. Cinnamon oil itself has antibacterial, anti-inflammatory, and antipruritic properties, which can alleviate skin itching caused by dryness and other issues, achieving a long-lasting soothing effect.

[0007] Cinnamon oil is a natural plant extract with potent antibacterial, anti-inflammatory, and antipruritic properties. The cinnamaldehyde it contains is a natural antibacterial and anti-inflammatory ingredient, and also a natural antioxidant, which can reduce the production of free radicals and slow the aging process. Furthermore, as a natural penetration enhancer, it promotes the absorption of active ingredients like squalane and vitamin E. Its distinctive aroma also helps regulate the odor of moisturizing compositions.

[0008] Vitamin E is an antioxidant with anti-photoaging properties. It protects skin cells from free radical damage, slows skin aging, promotes skin metabolism, prevents pigmentation, maintains skin elasticity, reduces wrinkles, and locks in moisture for long-lasting moisturization. Combining vitamin E with cinnamon oil enhances the permeability of both cinnamon oil and vitamin E. The two complement each other, synergistically increasing the permeability of the vitamin E, cinnamon oil, and squalane in the moisturizing composition, achieving long-lasting moisturizing and antioxidant properties.

[0009] As a preferred embodiment of the moisturizing composition of the present invention, the moisturizing composition comprises the following components by weight: 5.26 parts of moisturizing agent, 3.412 parts of emulsifier, 0.46 parts of skin softener, 0.092 parts of thickener, 0.092 parts of antioxidant synergist, 0.02 parts of preservative, 0.368 parts of vitamin E, 0.4 parts of cinnamon oil, and 30.316 parts of solvent. Under the preferred ratio, the present invention selects vitamin E and cinnamon oil and combines them with moisturizer, emulsifier, skin softener, thickener, antioxidant synergist, preservative, and water to form a moisturizing composition. Antioxidant tests and in vitro transdermal penetration tests found that the moisturizing composition under the preferred ratio has a better antioxidant effect, and the penetration effect of vitamin E and cinnamaldehyde (the main active ingredient of cinnamon oil) is better.

[0010] As a preferred embodiment of the moisturizing composition of the present invention, the moisturizing agent includes at least one of liquid paraffin, squalane, and glycerin; the mass ratio of liquid paraffin, squalane, and glycerin is liquid paraffin:squalane:glycerin = (0.808-1.308):(1.084-1.384):(2.568-2.968). Within the preferred mass ratio range, the inventors have experimentally confirmed that when the moisturizing agent is liquid paraffin, squalane, and glycerin, the resulting moisturizing composition has better moisturizing and soothing effects.

[0011] The liquid paraffin selected in the present invention is cosmetic grade liquid paraffin, which can increase the consistency and gloss of the moisturizing composition, is easy to spread, and can also seal moisture on the skin surface to prevent moisture evaporation and increase the moisturizing effect of the skin.

[0012] Squalane is an emollient and humectant that effectively moisturizes and protects the skin, preventing water loss while also promoting natural skin repair and balancing water and oil levels. Furthermore, squalane is stable and non-allergenic, providing antioxidant benefits while reducing skin allergies.

[0013] Glycerin, as a humectant, can be added to the moisturizing composition to prevent the evaporation of moisture in the skin, allowing the moisture in the moisturizing composition to be absorbed by the skin, thereby maintaining the moisture and softness of the skin and reducing problems such as dry and cracked skin.

[0014] As a preferred embodiment of the moisturizing composition of the present invention, the mass ratio of liquid paraffin, squalane and glycerin in the moisturizing agent is liquid paraffin:squalane:glycerin=1.108:1.384:2.768.

[0015] As a preferred embodiment of the moisturizing composition of the present invention, the emulsifier includes at least one of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80; the mass ratio of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80 is glyceryl monostearate: glyceryl caprylate: stearic acid: triethanolamine: Tween 80: Span 80 = (1.084-1.584): (0.54-0.94): (0.084-0.384): (0.084-0.384): (0.444-0.844): (0.052-0.292). Within the preferred type and mass ratio range, the inventors have experimentally confirmed that when the emulsifiers are glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80, the prepared moisturizing composition has better moisturizing and soothing effects.

[0016] As emulsifiers in moisturizing compositions, caprylic / capric glyceryl and isopropyl palmitate prevent whitening during application, while maintaining moisturizing properties and enhancing skin's radiance and elasticity. Stearic acid and glyceryl monostearate ensure uniformity and stability within the moisturizing composition, while also improving the hand cream's smoother texture. Tween 80 and Span 80 help evenly mix the oily and aqueous components, stabilizing the product's properties and increasing its spreadability. Triethanolamine improves the stability of the moisturizing composition.

[0017] As a preferred embodiment of the moisturizing composition of the present invention, the mass ratio of glyceryl monostearate, caprylic decanoate, stearic acid, triethanolamine, Tween 80 and Span 80 in the emulsifier is glyceryl monostearate: caprylic decanoate: stearic acid: triethanolamine: Tween 80: Span 80 = 1.384:0.74:0.184:0.184:0.644:0.276.

[0018] In a preferred embodiment of the moisturizing composition of the present invention, the preservative is ethylparaben; the antioxidant synergist is EDTA-2Na; the skin softener is isopropyl palmitate; and the thickener is carbomer 940. Carbomer 940, a synthetic polymer, thickens and adjusts the viscosity of the hand cream while also hydrating and alleviating dry skin. EDTA-2Na stabilizes the moisturizing composition.

[0019] As a preferred embodiment of the moisturizing composition of the present invention, the solvent is water.

[0020] In a second aspect, the present invention provides a method for preparing the above-mentioned moisturizing composition, comprising the following steps:

[0021] (1) Heat liquid paraffin, glyceryl monostearate, glyceryl caprylate, stearic acid, squalane, isopropyl palmitate, vitamin E, and triethanolamine at 70-80° C. until dissolved to obtain phase A;

[0022] Heat glycerol, Tween 80, Span 80, Carbomer 940, EDTA-2Na and water at 70-80°C until dissolved to obtain Phase B;

[0023] Mix ethylparaben and cinnamon oil to obtain phase C;

[0024] (2) Add phase B to phase A, then add phase C, stir and disperse, homogenize and emulsify at a speed of 400-600 r / min for 4-7 minutes, and continue stirring to obtain a moisturizing composition.

[0025] As a preferred embodiment of the preparation method of the present invention, it includes at least one of the following (I) to (II):

[0026] (I) In step (1), the heating condition of phase A and phase B is 75°C;

[0027] (II) In step (2), the rotation speed is 500 r / min and the emulsification time is 5 min.

[0028] In a third aspect, the present invention provides use of the above-mentioned moisturizing composition in the preparation of cosmetics.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] The present invention combines vitamin E and cinnamon oil with a moisturizer, an emulsifier, a skin softener, a thickener, an antioxidant synergist, a preservative, and water to form a moisturizing and nourishing composition. This composition promotes the penetration of vitamin E, provides long-lasting moisturizing, maintains skin elasticity, and repairs the epidermis. Furthermore, the moisturizing and nourishing composition also has excellent antioxidant properties and can be used to prepare a hand cream, providing long-lasting moisturizing and antioxidant benefits. Cinnamon oil itself has antibacterial, anti-inflammatory, and antipruritic properties, which can alleviate skin itching caused by dryness and other issues, achieving a long-lasting soothing effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is the cumulative penetration-time curve of vitamin E in different moisturizing compositions in Example 2 of the present invention;

[0032] Figure 2 This is the cumulative penetration-time curve of cinnamaldehyde in different moisturizing compositions in Effect Example 2 of the present invention. DETAILED DESCRIPTION

[0033] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0034] Unless otherwise specified, other materials, reagents, etc. used in the Examples, Comparative Examples, and Effect Examples can be obtained from commercial sources.

[0035] Examples 1-5 and Comparative Examples 1-4

[0036] Examples 1-5 and Comparative Examples 1-4 respectively provide a moisturizing composition and a preparation method thereof. The components and amounts of the moisturizing composition are shown in Table 1. The preparation method comprises the following steps:

[0037] (1) Heat the components of phase A in Table 1 at 75°C until dissolved to obtain phase A;

[0038] Heat the components of phase B in Table 1 at 75°C until dissolved to obtain phase B;

[0039] Mix ethylparaben and cinnamon oil to obtain phase C:

[0040] (2) Add phase B to phase A, then add phase C, stir and disperse, homogenize and emulsify at a speed of 500 r / min for 5 minutes, continue stirring, and cool to room temperature to obtain a moisturizing composition

[0041] Table 1 Components and amounts of different moisturizing compositions (parts by mass)

[0042]

[0043]

[0044] Effect Example 1

[0045] The moisturizing compositions obtained in Examples 1-3 and Comparative Examples 1-2 were subjected to a 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) free radical scavenging experiment to detect their antioxidant efficacy. The specific protocol is as follows:

[0046] Preparation of DPPH working solution: Accurately weigh 0.00394 g of DPPH into a 100 mL volumetric flask, dilute to the mark with anhydrous ethanol, and shake well to obtain a 0.1 mM DPPH ethanol solution.

[0047] Preparation of test solution: 2 g of the moisturizing composition of Examples 1-3 and Comparative Examples 1 and 2 were dissolved in 10 mL of anhydrous ethanol to prepare test solutions.

[0048] Accurately measure 2 mL of each test solution and 2 mL of DPPH working solution, mix them evenly, protect from light and react for 30 minutes, and measure the absorbance value A1 at a wavelength of 516 nm. 2 mL of anhydrous ethanol mixed with 2 mL of DPPH solution is determined as A0. The clearance rate is calculated according to the following formula. The results are shown in Table 2:

[0049]

[0050] Table 2 DPPH scavenging rate of different moisturizing compositions

[0051] Group DPPH clearance rate (%) Comparative Example 1 16.90％ Comparative Example 2 22.85％ Example 1 27.35％ Example 2 31.56％ Example 3 36.33％

[0052] As shown in Table 2, the DPPH scavenging rates of the moisturizing compositions of Examples 1-3 were much higher than those of Comparative Examples 1-2, with Example 3 having the highest DPPH scavenging rate. This indicates that the moisturizing compositions of the present invention have excellent antioxidant capacity. As the amount of cinnamon oil increases, its antioxidant capacity also increases. Furthermore, the addition of cinnamon oil can synergistically enhance the antioxidant capacity of squalane and vitamin E in the moisturizing compositions.

[0053] Effect Example 2

[0054] The moisturizing compositions obtained in Examples 1-3 and Comparative Examples 2-4 were subjected to an in vitro transdermal permeation test to detect the relationship between vitamin E and cinnamon oil. The specific protocol is as follows:

[0055] Vitamin E standard solutions with concentrations of and were prepared, and their absorbance at 291 nm was measured. A standard curve was plotted with vitamin E concentration as the horizontal axis and the absorbance corresponding to different concentrations as the vertical axis. The vitamin E concentration of the test samples was calculated according to the standard curve. The standard curve construction method for cinnamaldehyde was similar to that for vitamin E, except that the absorbance was measured at a wavelength of 284 nm.

[0056] Eight male SD rats (220-250 g) were acclimated for 24 hours. After anesthesia with isoflurane, the long hair on the abdomen was shaved, and the remaining short hair was removed with a depilatory cream. After 24 hours of feeding, the rats were sacrificed. The skin of the rats at the hairless area was immediately cut and laid flat on the reverse side to separate the subcutaneous tissue and fat. The skin was repeatedly rinsed with 0.9% saline until clean. The intact skin was immersed in 0.9% saline and stored frozen at -20°C until ready for use.

[0057] Take the spare rat skin and thaw it, fix it to one end of the diffusion cell, make the skin surface face the supply chamber, fill the receiving chamber with 30% ethanol saline solution, make it in close contact with the dermis, (37±0.5)℃, 100r / min constant speed magnetic stirring, turn on the TP-6 ​​transdermal diffusion tester, make it pre-equilibrate for 30 minutes, then accurately weigh 2g of the moisturizing composition of Examples 1-3 and Control Examples 2-4 and place it in the supply chamber, make it in close contact with the skin and apply it evenly, and conduct 3 parallel experiments in each group. Sample 4mL at 0.5, 1, 2, 4, 6, 8, 10, 12, and 24h, and supplement with an equal volume of receiving solution. After filtering the sample with a 0.22μm microporous filter membrane, use ultraviolet spectrophotometry to determine the content of vitamin E and cinnamaldehyde, and calculate the cumulative penetration amount Q. The results are shown in Tables 3-4 and Figure 1-2 The cumulative penetration calculation formula is as follows:

[0058]

[0059] Where V 总 is the total volume of the receiving liquid in the receiving chamber; Cn is the sample concentration measured at the nth sampling point; Ci is the drug concentration in the receiving liquid from the first sampling to the last sampling, i = 1, 2, ..., n-1; V 取 is the volume of each sampling; A is the penetration area (cm 2 ).

[0060] Table 3 Cumulative penetration of vitamin E in different moisturizing compositions (mg / cm 2 )

[0061]

[0062]

[0063] Depend on Figure 1 As can be seen from Table 3, the cumulative permeation amounts of Examples 1-3 are higher than those of Comparative Examples 2-4, showing superior permeability. This indicates that cinnamon oil can greatly promote the permeation of vitamin E. The cumulative permeation amounts are significantly different from those of Comparative Examples 3 and 4 containing rose essential oil and sweet orange oil. This indicates that, compared with commonly used plant essential oils, the use of cinnamon oil can not only harmonize the odor of the moisturizing composition but also promote the permeation of the active ingredient vitamin E, thereby better exerting its moisturizing, hydrating, and antioxidant effects. In addition, the cumulative permeation amount shows an upward trend within 24 hours, indicating that cinnamon oil can promote the transdermal absorption of vitamin E for a long time, achieving a long-lasting moisturizing and antioxidant effect.

[0064] Table 4 Cumulative penetration of cinnamaldehyde in different moisturizing compositions (mg / cm 2 )

[0065] Sampling time / h Example 1 Example 2 Example 3 0.5 0.007 0.057 0.050 1 0.010 0.097 0.110 2 0.016 0.156 0.202 4 0.028 0.214 0.336 6 0.039 0.262 0.517 8 0.049 0.306 0.616 10 0.060 0.370 0.720 12 0.070 0.434 0.989 24 0.115 0.581 1.208

[0066] The main component of cinnamon oil is cinnamaldehyde, so the cumulative permeation of cinnamon oil was determined by measuring the cumulative permeation of cinnamonaldehyde. Figure 2 It can be seen that the cumulative penetration amount of cinnamaldehyde in the three groups of examples continues to increase, which shows that cinnamaldehyde has good skin permeability and continues to penetrate within 24 hours, indicating that cinnamaldehyde can exert its antibacterial and antipruritic effects for a long time and achieve a long-lasting soothing effect.

[0067] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A moisturizing composition, characterized in that: The moisturizing and nourishing composition comprises the following components in parts by mass: 4.48-5.86 parts of a moisturizing agent, 2.236-4.612 parts of an emulsifier, 0.26-0.66 parts of a skin softener, 0.052-0.292 parts of a thickener, 0.052-0.292 parts of an antioxidant synergist, 0.01-0.22 parts of a preservative, 0.168-0.568 parts of vitamin E, 0.04-0.4 parts of cinnamon oil, and 30.116-30.516 parts of a solvent; The moisturizing agent is at least one of liquid paraffin, squalane and glycerin; The emulsifier is at least one of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80; The antioxidant synergist is EDTA-2Na.

2. The moisturizing composition according to claim 1, wherein The moisturizing composition includes the following components in parts by mass: 5.26 parts of moisturizer, 3.412 parts of emulsifier, 0.46 parts of skin softener, 0.092 parts of thickener, 0.092 parts of antioxidant synergist, 0.02 parts of preservative, 0.368 parts of vitamin E, 0.4 parts of cinnamon oil and 30.316 parts of solvent.

3. The moisturizing and nourishing composition according to claim 1 or 2, wherein: The mass ratio of liquid paraffin, squalane and glycerin in the moisturizing agent is liquid paraffin:squalane:glycerin=(0.808-1.308):(1.084-1.384):(2.568-2.968).

4. The moisturizing composition according to claim 3, wherein The mass ratio of liquid paraffin, squalane and glycerin in the moisturizing agent is liquid paraffin:squalane:glycerin=1.108:1.384:2.

768.

5. The moisturizing and nourishing composition according to claim 1 or 2, wherein: The mass ratio of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80 in the emulsifier is glyceryl monostearate: glyceryl caprylate: stearic acid: triethanolamine: Tween 80: Span 80 = (1.084-1.584): (0.54-0.94): (0.084-0.384): (0.084-0.384): (0.444-0.844): (0.052-0.292).

6. The moisturizing composition according to claim 5, wherein The mass ratio of glyceryl monostearate, glyceryl caprylate, stearic acid, triethanolamine, Tween 80 and Span 80 in the emulsifier is glyceryl monostearate: glyceryl caprylate: stearic acid: triethanolamine: Tween 80: Span 80 = 1.384:0.74:0.184:0.184:0.644:0.

276.

7. The moisturizing and nourishing composition according to claim 1 or 2, wherein: The preservative is ethylparaben; the skin softener is isopropyl palmitate; and the thickener is carbomer 940.

8. The method for preparing the moisturizing composition according to any one of claims 1 to 7, wherein: The following steps are involved: (1) Heat liquid paraffin, glyceryl monostearate, glyceryl caprylate, stearic acid, squalane, isopropyl palmitate, vitamin E, and triethanolamine at 70-80° C. until dissolved to obtain phase A; Heat glycerol, Tween 80, Span 80, Carbomer 940, EDTA-2Na and water at 70-80°C until dissolved to obtain Phase B; Mix ethylparaben and cinnamon oil to obtain phase C; (2) Add phase B to phase A, then add phase C, stir and disperse, homogenize and emulsify at a speed of 400-600 r / min for 4-7 minutes, and continue stirring to obtain a moisturizing composition.

9. The preparation method according to claim 8, wherein Including at least one of the following (I) to (II): (I) In step (1), the heating condition of phase A and phase B is 75°C; (II) In step (2), the rotation speed is 500 r / min and the emulsification time is 5 min.

10. Use of the moisturizing composition according to any one of claims 1 to 7 in the preparation of cosmetics.

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