A hollow microneedle

Abstract

The present invention discloses a hollow microneedle, which relates to the field of medical device technology. The needle comprises a base and a needle head disposed on the upper portion of the base. The needle head comprises a liquid outlet bevel, a rear side surface, and two side connecting structures. Both sides of the liquid outlet bevel are connected to the rear side surface via a side connecting structure. The liquid outlet bevel, the rear side surface, and the two side connecting structures form a needle tip at one end away from the base, or the rear side surface and the two side connecting structures form a needle tip at one end away from the base. The liquid outlet bevel is provided with a liquid outlet port, a liquid outlet channel is provided in the needle head, and a liquid inlet channel is provided in the base. The two ends of the liquid outlet channel are respectively connected to the liquid outlet port and one end of the liquid inlet channel, and the other end of the liquid inlet channel passes through the bottom of the base. The hollow microneedle prevents skin debris from clogging the liquid outlet port during skin puncture, thereby ensuring the stability of the liquid outlet port and the overall stability of the needle head, and preventing the needle from breaking or failing to pierce the skin.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a hollow microneedle. Background Art

[0002] Microneedles can destroy the surface layer of the skin for microinjection, creating micron-scale channels that deliver drugs or active ingredients directly to the epidermis to participate in microcirculation. They can penetrate the stratum corneum to form drug delivery channels without stimulating the subcutaneous pain nerves. Microneedle drug delivery has broad application prospects. Currently, the microneedles on the market mainly include solid microneedles, hollow microneedles, soluble microneedles, coated microneedles, and hydrogel microneedles.

[0003] Hollow microneedles, with their hollow structure, can not only carry drugs but also regulate the release rate of drugs or active substances, enabling precise drug delivery. However, existing hollow microneedles use a conventional open-tip structure, which can easily clog the needle hole after puncturing the skin. The hollow structure of the needle tip also results in a thin wall thickness, insufficient mechanical strength, and a high risk of needle breakage or failure to penetrate the skin, posing safety and usage risks. Summary of the Invention

[0004] In order to solve the above technical problems, the present invention provides a hollow microneedle to prevent skin fragments from clogging the liquid outlet during the process of piercing the skin, thereby ensuring the stability of the liquid outlet and the overall stability of the needle, and avoiding needle breakage or inability to penetrate the skin.

[0005] To achieve the above object, the present invention provides the following solutions:

[0006] The present invention provides a hollow microneedle, comprising a base and a needle head arranged on the upper part of the base, the needle head comprising a liquid outlet slope, a rear side surface and two side connecting structures, both sides of the liquid outlet slope are connected to the rear side surface through one of the side connecting structures, the liquid outlet slope, the rear side surface and the two side connecting structures form a needle tip at one end away from the base, or the rear side surface and the two side connecting structures form a needle tip at one end away from the base; a liquid outlet is provided on the liquid outlet slope, a liquid outlet channel is provided in the needle head, and a liquid inlet channel is provided in the base, the two ends of the liquid outlet channel are respectively connected to the liquid outlet and one end of the liquid inlet channel, and the other end of the liquid inlet channel passes through the bottom of the base.

[0007] Preferably, the base includes a base and a shell arranged on the upper part of the base, the needle is arranged on the upper part of the shell, the liquid outlet channel includes an intermediate channel and a hollow area connected in sequence from top to bottom, the upper end of the intermediate channel is connected to the lower end of the liquid outlet channel, the hollow area is arranged on the base and passes through the bottom of the base, and the hollow area is used to install a liquid propulsion device.

[0008] Preferably, the connected intermediate channel and the liquid outlet channel form a tapered channel, and the cross-sectional area of ​​the tapered channel gradually decreases from an end away from the needle tip to an end close to the needle tip.

[0009] Preferably, a plurality of needles are provided on the upper portion of the shell, the liquid outlet channel includes a plurality of intermediate channels, and the upper and lower ends of each intermediate channel are respectively connected to the lower end of a liquid outlet channel and the hollow area.

[0010] Preferably, the side connection structure includes a side vertical surface and an oblique surface, the liquid outlet inclined surface, the rear side surface and the bottom of the side vertical surface are all connected to the upper surface of the base, the front and rear sides of the side vertical surface are respectively connected to one side of the liquid outlet inclined surface and one side of the rear side surface, the connection between the side vertical surface and the rear side surface is cut to form the oblique surface, and the liquid outlet inclined surface, the rear side surface and the two oblique surfaces form the needle tip at one end away from the base.

[0011] Preferably, the side vertical surface is perpendicular to the upper surface of the base, the rear side surface is perpendicular to the upper surface of the base, and the rear side surface is a plane or an arc surface; the connection between the side vertical surface and the liquid outlet inclined surface, the connection between the side vertical surface and the beveled surface, the connection between the beveled surface and the rear side surface, and the connection between the beveled surface and the liquid outlet inclined surface all adopt an arc corner structure.

[0012] Preferably, the side connecting structure includes a first side surface and a transition connecting structure, the rear side surface and the bottom of the first side surface are connected to the upper surface of the base, the front side of each first side surface is connected to the front side of another first side surface, and the rear side of each first side surface is connected to one side of the rear side surface, the rear side surface and the end of the two first side surfaces away from the base form the needle tip, the liquid outlet slope is arranged on the intersection line of the two first side surfaces, the inclination angle of the liquid outlet slope is consistent with the inclination angle of the intersection line of the two first side surfaces, and both sides of the liquid outlet slope are connected to one of the first side surfaces through a transition connecting structure.

[0013] Preferably, the transition connection structure includes a second side surface and a third side surface, the lower part of the second side surface is connected to the first side surface, the front side of the second side surface is connected to the lower part of the liquid outlet slope side, the rear side of the second side surface is connected to the front side of the third side surface, the rear side of the third side surface is connected to the first side surface, and the upper part of the third side surface is connected to the upper part of the liquid outlet slope side.

[0014] Preferably, the connection between the second side surface and the liquid outlet slope, the connection between the second side surface and the third side surface, the connection between the third side surface and the liquid outlet slope, the connection between the first side surface and the rear side surface, and the connection between the two first side surfaces all adopt an arc corner structure.

[0015] Preferably, the rear side surface is perpendicular to the upper surface of the base, and the rear side surface is a plane; the liquid outlet slope is diamond-shaped or teardrop-shaped, and the liquid outlet is arranged at the maximum width of the liquid outlet slope, and the width of the liquid outlet slope decreases upward from the location where the liquid outlet is arranged, and the width of the liquid outlet slope decreases downward from the location where the liquid outlet is arranged.

[0016] Compared with the prior art, the present invention has achieved the following technical effects:

[0017] The hollow microneedle of the present invention includes a base and a needle head arranged on the upper part of the base, the needle head includes a liquid outlet slope, a rear side surface and two side connection structures, both sides of the liquid outlet slope are connected to the rear side surface through a side connection structure, the liquid outlet slope, the rear side surface and the two side connection structures form a needle tip at one end away from the base, or the rear side surface and the two side connection structures form a needle tip at one end away from the base. A liquid outlet is provided on the liquid outlet slope. It can be seen that in the present application, the liquid outlet is located on the liquid outlet slope on one side of the needle head, which can not only avoid skin debris blocking the liquid outlet during the process of piercing the skin, ensuring that the liquid can flow out smoothly from the liquid outlet, but also can increase the thickness of the material at the liquid outlet without affecting the sharpness of the needle tip, making the position of the liquid outlet more stable, ensuring the stability of the liquid outlet and the overall stability of the needle head, improving the mechanical strength of the needle head, and avoiding the situation where the needle breaks or cannot pierce the skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0019] Figure 1 A first three-dimensional structural diagram of a hollow microneedle provided in Example 1 of the present invention when provided with a needle head;

[0020] Figure 2 A second three-dimensional structural diagram of the hollow microneedle provided in Example 1 of the present invention when provided with a needle head;

[0021] Figure 3 A cross-sectional view of a hollow microneedle provided in Example 1 of the present invention when provided with a needle tip;

[0022] Figure 4 A front view of the needle tip of the hollow microneedle provided in Example 1 of the present invention;

[0023] Figure 5 A rear view of the needle tip of the hollow microneedle provided in Example 1 of the present invention;

[0024] Figure 6 A side view of the needle tip of the hollow microneedle provided in Example 1 of the present invention;

[0025] Figure 7 A top view of the needle tip of the hollow microneedle provided in Example 1 of the present invention;

[0026] Figure 8 This is a schematic structural diagram of a hollow microneedle provided in Example 1 of the present invention when two needles are provided;

[0027] Figure 9 A schematic structural diagram of a hollow microneedle provided in Example 1 of the present invention having three needles;

[0028] Figure 10 A first three-dimensional structural diagram of a hollow microneedle provided in Example 2 of the present invention when provided with a needle head;

[0029] Figure 11 A second three-dimensional structural diagram of a hollow microneedle provided in the second embodiment of the present invention with one needle head;

[0030] Figure 12 A front view of the needle tip of the hollow microneedle provided in Example 2 of the present invention;

[0031] Figure 13 A rear view of the needle tip of the hollow microneedle provided in Example 2 of the present invention;

[0032] Figure 14 A side view of the needle tip of the hollow microneedle provided in Example 2 of the present invention;

[0033] Figure 15 A top view of the needle tip of the hollow microneedle provided in Example 2 of the present invention;

[0034] Figure 16 A schematic structural diagram of a hollow microneedle provided in Example 2 of the present invention having two needles;

[0035] Figure 17 A schematic structural diagram of a hollow microneedle provided in Example 2 of the present invention having three needles;

[0036] Figure 18 A schematic structural diagram of a hollow microneedle provided in Example 3 of the present invention when provided with a needle head;

[0037] Figure 19A cross-sectional view of a hollow microneedle provided in Example 3 of the present invention with a needle tip;

[0038] Figure 20 A first three-dimensional structural diagram of the needle tip of the hollow microneedle provided in Example 3 of the present invention;

[0039] Figure 21 A second three-dimensional structural diagram of the needle tip of the hollow microneedle provided in Example 3 of the present invention;

[0040] Figure 22 This is a schematic structural diagram of a hollow microneedle provided in Example 3 of the present invention when two needles are provided;

[0041] Figure 23 A schematic structural diagram of a hollow microneedle provided in Example 3 of the present invention having three needles;

[0042] Figure 24 A first three-dimensional structural diagram of a hollow microneedle provided in Example 4 of the present invention with one needle head;

[0043] Figure 25 A second three-dimensional structural diagram of a hollow microneedle provided in Example 4 of the present invention with one needle head;

[0044] Figure 26 This is a schematic structural diagram of a hollow microneedle provided in Example 4 of the present invention when two needles are provided;

[0045] Figure 27 This is a schematic structural diagram of a hollow microneedle provided in Example 4 of the present invention having three needles.

[0046] Explanation of the accompanying reference numerals: 1. base; 2. shell; 3. hollow area; 4. middle channel; 5. needle; 6. needle tip; 7. liquid outlet channel; 8. liquid outlet; 9. liquid outlet slope; 10. rear side; 11. vertical side; 12. oblique cutting surface; 13. first side; 14. second side; 15. third side. DETAILED DESCRIPTION

[0047] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0048] The purpose of the present invention is to provide a hollow microneedle to prevent skin fragments from clogging the liquid outlet during the process of piercing the skin, ensure the stability of the liquid outlet and the overall stability of the needle, and avoid needle breakage or inability to pierce the skin.

[0049] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0050] Example 1:

[0051] like Figures 1-9 As shown, this embodiment provides a hollow microneedle, including a base and a needle 5 arranged on the upper part of the base, and the needle 5 and the base are connected along the axial direction of the hollow microneedle. The needle 5 includes a liquid outlet slope 9, a rear side surface 10 and two side connection structures. Both sides of the liquid outlet slope 9 are connected to the rear side surface 10 through a side connection structure. The bottom of the side connection structure and the rear side surface 10 are connected to the upper surface of the base. The rear side surface 10 is perpendicular to the upper surface of the base. The rear side surface 10 is a plane or an arc surface. In this embodiment, the rear side surface 10 located on the other side of the liquid outlet slope 9 is a flat structure to avoid causing cutting damage to the skin. The liquid outlet slope 9, the rear side surface 10 and the two side connection structures form a needle tip 6 at one end away from the base, or the rear side surface 10 and the two side connection structures form a needle tip 6 at one end away from the base. The formed needle tip 6 facilitates piercing the skin, allowing the needle 5 to penetrate subcutaneously. A liquid outlet 8 is provided on the liquid outlet slope 9, a liquid outlet channel 7 is provided in the needle 5, and a liquid inlet channel is provided in the base. The two ends of the liquid outlet channel 7 are respectively connected to the liquid outlet 8 and one end of the liquid inlet channel, and the other end of the liquid inlet channel passes through the bottom of the base. The liquid inlet channel and the liquid outlet channel 7 form a liquid channel for liquid circulation, which is used for injecting liquid medicine or collecting tissue fluid.

[0052] In this embodiment, the liquid outlet 8 is located on the liquid outlet slope 9 on one side of the needle 5. This not only prevents skin debris from clogging the liquid outlet 8 during the skin puncture process, ensuring that the liquid can flow out smoothly from the liquid outlet 8, but also increases the thickness of the material at the liquid outlet 8 without affecting the sharpness of the needle tip 6, making the position of the liquid outlet 8 more stable, ensuring the stability of the liquid outlet 8 and the overall stability of the needle 5, improving the mechanical strength of the needle 5, and avoiding the situation where the needle breaks or cannot penetrate the skin. The liquid outlet 8 is opened on the side of the needle 5 to reduce the risk of drug leakage and improve drug delivery efficiency.

[0053] Specifically, hollow microneedles can be prepared through surface projection 3D printing technology and metal powder injection molding technology, with controllable materials and shapes.

[0054] The base includes a base 1 and a shell 2 arranged on the upper part of the base 1, the needle 5 is arranged on the upper part of the shell 2, the liquid outlet channel 7 includes an intermediate channel 4 and a hollow area 3 connected in sequence from top to bottom, the upper end of the intermediate channel 4 is connected to the lower end of the liquid outlet channel 7, the hollow area 3 is arranged on the base 1 and passes through the bottom of the base 1, and the hollow area 3 is used to install the liquid propulsion device.

[0055] The base serves as both a carrier for the needle 5 and a connection to a liquid propulsion device, including but not limited to a syringe. The size of the hollow region 3 of the base can be customized according to the connection location of the liquid propulsion device to ensure a tight connection between the hollow microneedle and the liquid propulsion device.

[0056] The base can also play a stopping role. When the needle 5 penetrates the skin, the base contacts the skin, so that the needle 5 cannot continue to penetrate the deep skin, especially the subcutaneous layer, after penetrating the skin to a certain depth, thereby avoiding bleeding and pain.

[0057] The connected middle channel 4 and the liquid outlet channel 7 form a tapered channel, and the cross-sectional area of ​​the tapered channel gradually decreases from the end away from the needle tip 6 to the end close to the needle tip 6.

[0058] Specifically, when 3D printing technology is used, the channels will gradually shrink as they are printed layer by layer from the bottom up. Therefore, the connected intermediate channel 4 and the liquid outlet channel 7 become conical channels that are wide at the bottom and narrow at the top. When the metal powder injection molding technology is used for preparation and laser drilling is continued, the hole formed by ablating the material at the incident port is also conical, that is, the connected intermediate channel 4 and the liquid outlet channel 7 become conical channels that are wide at the bottom and narrow at the top.

[0059] The tapered channel in this embodiment is a conical channel, and the angle between the generatrix of the conical channel and the central axis is 2° to 10°.

[0060] The upper portion of the housing 2 is provided with multiple needles 5. The liquid outlet channel 7 includes multiple intermediate channels 4. The upper and lower ends of each intermediate channel 4 are respectively connected to the lower end of a liquid outlet channel 7 and the hollow area 3. That is, the intermediate channels 4 correspond one-to-one with the liquid outlet channels 7, and each intermediate channel 4 forms a tapered channel with the corresponding liquid outlet channel 7.

[0061] In this embodiment, the multiple needles 5 are arranged in an orderly manner, either in a row or in a regular array. When piercing the skin, the skin will sag due to surface tension. Therefore, the center-to-center spacing between adjacent needles 5 should be larger than the size of the skin sag; otherwise, it will be difficult for the needles 5 to penetrate the skin. Accordingly, in this embodiment, the center-to-center spacing between adjacent needles 5 is greater than 200 μm.

[0062] like Figure 2 、 8 As shown in FIG9 , the needle heads 5 of the hollow microneedle in this embodiment can be set to one, two or three. It should be noted that the number of the needle heads 5 is not limited to the above numbers.

[0063] Specifically, the height of the needle tip 5 is 610 μm to 850 μm, the width of the bottom of the needle tip 5 is 140 μm to 500 μm, and the length of the bottom of the needle body is 140 μm to 600 μm. The diameter of the liquid inlet end of the tapered channel is larger than the diameter of the liquid outlet end of the tapered channel. The diameter of the liquid inlet end of the tapered channel (far from the needle tip 6) is 60 μm to 300 μm, and the diameter of the liquid outlet end of the tapered channel (close to the needle tip 6) is 40 μm to 100 μm.

[0064] Specifically, there is no limit to the height of the base and it can be adjusted according to the needs of use, wherein the height of the base 1 is greater than or equal to 0 μm. When the height of the base 1 is 0 μm, that is, there is no base 1, the hollow area 3 is set at the lower part of the shell 2.

[0065] The housing 2 has a stepped shape, narrow at the top and wide at the bottom. The width of the upper surface of the housing 2 is 1000 μm. The size of the upper surface of the housing 2 can be adjusted according to the number of needles 5. The length of the upper surface of the housing 2 is at least greater than the length of the base of the needles 5, and the width of the upper surface of the housing 2 is at least greater than the width of the base of the needles 5. The length of the base 1 is 2200 μm, the width is 2000 μm, and the height of the base 1 is 600 μm. The height of the hollow area 3 can be adjusted according to the length of the connection part of the liquid propulsion device. The height of the hollow area 3 must be greater than 300 μm to ensure the structural stability of the base.

[0066] When needle 5 penetrates the skin, the skin's force on needle 5 is sequentially intercepted by needle tip 6, then by the liquid outlet ramp 9, and then by the base, preventing further penetration. The structural design of needle 5 increases mechanical strength and reduces the risk of needle breakage. The base design limits the penetration depth of needle 5, protecting the skin.

[0067] Specifically, the side connection structure includes a side vertical surface 11 and an oblique surface 12. The liquid outlet slope 9, the rear side surface 10 and the bottom of the side vertical surface 11 are all connected to the upper surface of the base. The front and rear sides of the side vertical surface 11 are respectively connected to one side of the liquid outlet slope 9 and one side of the rear side surface 10. The connection between the side vertical surface 11 and the rear side surface 10 is cut to form the oblique surface 12. The liquid outlet slope 9, the rear side surface 10 and the two oblique surfaces 12 form a needle tip 6 at the end away from the base.

[0068] The presence of the liquid outlet bevel 9 reduces the sharpness of the needle tip 6. Therefore, in this embodiment, two beveled surfaces 12 are added to the needle tip 6 to increase its sharpness and sharpness, making it unaffected by changes in the shape of the needle head 5. The design of the two beveled surfaces 12 ensures that the sharpness of the needle tip 6 is controllable, making it easier for the needle head 5 to pierce the skin and reach deeper structures. Specifically, by providing the two beveled surfaces 12, the included angle range of the needle tip 6 is controlled between 10° and 60°.

[0069] Specifically, the side vertical surface 11 is perpendicular to the upper surface of the base, and the rear side surface 10 is perpendicular to the upper surface of the base.

[0070] Specifically, the connection between the side vertical surface 11 and the liquid outlet slope 9, the connection between the side vertical surface 11 and the beveled surface 12, the connection between the beveled surface 12 and the rear side surface 10, and the connection between the beveled surface 12 and the liquid outlet slope 9 all adopt an arc corner structure to avoid cutting damage to the skin around the needle hole after puncturing the skin, thereby reducing the degree of damage to the skin and obtaining the smallest wound size.

[0071] In this embodiment, the rear side surface 10 is a plane, and the vertical side surface 11 is perpendicular to the rear side surface 10 .

[0072] Example 2:

[0073] like Figures 10-17 As shown, this embodiment provides a hollow microneedle. The difference between this embodiment and the first embodiment lies in the shape of the rear side surface 10. In this embodiment, the rear side surface 10 is an arc surface. Specifically, the rear side surface 10 is a semicircular arc surface, and the two side vertical surfaces 11 are tangent to the two ends of the semicircular arc surface respectively.

[0074] like Figure 11 、 16 As shown in FIG17 , the needle heads 5 of the hollow microneedle in this embodiment can be set to one, two or three. It should be noted that the number of the needle heads 5 is not limited to the above numbers.

[0075] Example 3:

[0076] like Figures 18-23 As shown, this embodiment provides a hollow microneedle. The difference between this embodiment and the first embodiment lies in the specific structure of the side connection structure.

[0077] Specifically, the side connection structure includes a first side surface 13 and a transition connection structure. The bottoms of the rear side surface 10 and the first side surface 13 are both connected to the upper surface of the base. The front side of each first side surface 13 is connected to the front side of another first side surface 13, and the rear side of each first side surface 13 is connected to one side of the rear side surface 10. The rear side surface 10 and the ends of the two first side surfaces 13 away from the base form a needle tip 6. In this embodiment, the needle tip 6 is a triangular pyramid tip, sharp and structurally stable. The liquid outlet slope 9 is arranged at the intersection of the two first side surfaces 13. The inclination angle of the liquid outlet slope 9 is consistent with the inclination angle of the intersection of the two first side surfaces 13. Both sides of the liquid outlet slope 9 are connected to one first side surface 13 via a transition connection structure. The liquid outlet 8 has a certain thickness, so that the shape of the liquid outlet 8 remains intact and is not easily deformed. The liquid outlet 8 located on the side of the needle 5 is not easily blocked during the skin puncture process. This design not only ensures the sharpness of the needle tip 6, facilitating skin puncture, but also increases the structural stability of the needle 5.

[0078] The transition connection structure includes a second side surface 14 and a third side surface 15. The lower part of the second side surface 14 is connected to the first side surface 13, the front side of the second side surface 14 is connected to the lower part of the liquid outlet slope 9, the rear side of the second side surface 14 is connected to the front side of the third side surface 15, the rear side of the third side surface 15 is connected to the first side surface 13, and the upper part of the third side surface 15 is connected to the upper part of the liquid outlet slope 9.

[0079] Specifically, the connection between the second side surface 14 and the liquid outlet slope 9, the connection between the second side surface 14 and the third side surface 15, the connection between the third side surface 15 and the liquid outlet slope 9, the connection between the first side surface 13 and the rear side surface 10, and the connection between the two first side surfaces 13 all adopt an arc corner structure to avoid cutting damage to the skin around the needle hole after puncturing the skin, thereby reducing the degree of damage to the skin and obtaining the smallest wound size.

[0080] Specifically, the rear side surface 10 is perpendicular to the upper surface of the base, and the rear side surface 10 is a plane.

[0081] In this embodiment, the liquid outlet slope 9 is diamond-shaped, with the angle between the upper two sides of the diamond-shaped liquid outlet slope 9 being greater than the angle between the lower two sides. The liquid outlet 8 is located at the maximum width of the liquid outlet slope 9. The width of the liquid outlet slope 9 decreases upward from the location of the liquid outlet 8, and the width of the liquid outlet slope 9 decreases downward from the location of the liquid outlet 8. This design ensures the thickness of the liquid outlet 8 while ensuring that the sharpness of the needle 5 is not significantly affected.

[0082] like Figure 18 、 22 As shown in FIG23 , the needle heads 5 of the hollow microneedle in this embodiment can be set to one, two or three. It should be noted that the number of the needle heads 5 is not limited to the above numbers.

[0083] Example 4:

[0084] like Figure 24-27 As shown, this embodiment provides a hollow microneedle. This embodiment differs from the third embodiment in the shape of the liquid outlet slope 9. In this specific embodiment, the liquid outlet slope 9 is teardrop-shaped, with the tip of the teardrop-shaped liquid outlet slope 9 located at the bottom. The liquid outlet 8 is located at the maximum width of the liquid outlet slope 9. The width of the liquid outlet slope 9 decreases upward from the location of the liquid outlet 8, and the width of the liquid outlet slope 9 decreases downward from the location of the liquid outlet 8. This design ensures that the thickness of the liquid outlet 8 is maintained while ensuring that the sharpness of the needle tip 5 is not significantly affected.

[0085] like Figure 24 、 26 As shown in FIG27 , the needle heads 5 of the hollow microneedle in this embodiment can be set to one, two or three. It should be noted that the number of the needle heads 5 is not limited to the above numbers.

[0086] This specification uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only intended to help understand the method and core concept of the present invention. At the same time, those skilled in the art will find that the specific implementation methods and application scopes may vary based on the concept of the present invention. In summary, the contents of this specification should not be construed as limiting the present invention.

Claims

1. A hollow microneedle, characterized in that: The top end of the needle is connected to the bottom end of the base by a threaded cantilever cam, and the bottom end of the needle is connected to the bottom end of the base by a threaded cantilever cam. The inserting mechanism of the present invention is a pair of interlocking members, each of which is connected to the top of the inserting mechanism, and the interlocking members are connected to each other at the bottom of the inserting mechanism.

2. The hollow microneedle according to claim 1, wherein The base includes a base and a shell arranged on the upper part of the base, the needle is arranged on the upper part of the shell, the liquid outlet channel includes an intermediate channel and a hollow area connected in sequence from top to bottom, the upper end of the intermediate channel is connected to the lower end of the liquid outlet channel, the hollow area is arranged on the base and passes through the bottom of the base, and the hollow area is used to install a liquid propulsion device.

3. The hollow microneedle according to claim 2, characterized in that The connected middle channel and the liquid outlet channel form a tapered channel, and the cross-sectional area of ​​the tapered channel gradually decreases from the end away from the needle tip to the end close to the needle tip.

4. The hollow microneedle according to claim 2, wherein A plurality of needles are provided on the upper portion of the shell, and the liquid outlet channel includes a plurality of intermediate channels. The upper and lower ends of each intermediate channel are respectively connected to the lower end of a liquid outlet channel and the hollow area.

5. The hollow microneedle according to claim 1, wherein The side vertical surface is perpendicular to the upper surface of the base, the rear side surface is perpendicular to the upper surface of the base, and the rear side surface is a plane or an arc surface; the connection between the side vertical surface and the liquid outlet inclined surface, the connection between the side vertical surface and the beveled surface, the connection between the beveled surface and the rear side surface, and the connection between the beveled surface and the liquid outlet inclined surface all adopt an arc corner structure.

6. The hollow microneedle according to claim 1, wherein The transition connection structure includes a second side surface and a third side surface, the lower part of the second side surface is connected to the first side surface, the front side of the second side surface is connected to the lower part of the liquid outlet slope, the rear side of the second side surface is connected to the front side of the third side surface, the rear side of the third side surface is connected to the first side surface, and the upper part of the third side surface is connected to the upper part of the liquid outlet slope surface.

7. The hollow microneedle according to claim 6, characterized in that The connection between the second side surface and the liquid outlet slope, the connection between the second side surface and the third side surface, the connection between the third side surface and the liquid outlet slope, the connection between the first side surface and the rear side surface, and the connection between the two first side surfaces all adopt an arc corner structure.

8. The hollow microneedle according to claim 1, wherein The rear side surface is perpendicular to the upper surface of the base, and the rear side surface is a plane; the liquid outlet slope is diamond-shaped or teardrop-shaped, and the liquid outlet is arranged at the maximum width of the liquid outlet slope. The width of the liquid outlet slope decreases upward from the location where the liquid outlet is arranged, and the width of the liquid outlet slope decreases downward from the location where the liquid outlet is arranged.

Images