A continuous dynamic production of low-temperature frozen vacuum drying system and production method

Abstract

The application discloses a kind of continuous dynamic production's low-temperature frozen vacuum drying system and production method, including vacuum drying cabin, setting in the bottom of vacuum drying cabin discharging buffer cabin, with vacuum drying cabin through first pipeline communication vacuum filter, with vacuum filter through second pipeline communication vacuum pump group, with the bottom of discharging buffer cabin through third pipeline communication material collector and with material collector top through fourth pipeline communication air blower, the bottom of vacuum filter is communicated with material collector through fifth pipeline, and the air blowing side of air blower is communicated with the top of vacuum filter through sixth pipeline.The application can realize dynamic continuous production, realize the rapid automatic discharge of material and process material in vacuum drying cavity, greatly improve production efficiency.

Description

Technical Field

[0001] This invention belongs to the technical field of freeze-drying equipment, and in particular relates to a low-temperature freeze-vacuum drying system and production method for continuous dynamic production. Background Technology

[0002] Vacuum freeze-drying technology is commonly used in food processing, medical powder processing, and other fields. Traditional freeze-drying equipment uses a tray structure, such as the vacuum freeze-drying food dryer disclosed in patent CN118602699A. Raw material solutions containing moisture or other solvents are injected into the freeze-drying trays. In some cases, the freeze-drying trays and plates are integrated, while in others they are separate. Receiving material from this type of dryer is a very cumbersome task. In most cases, the trays must be removed together with the material, requiring manual operation. Even if the freeze-drying trays and plates are integrated, achieving a degree of automation in feeding and discharging and reducing personnel contamination, the material still needs to be pulverized after discharge. Pulverization requires an equally clean environment, thus demanding a high level of cleanliness in the entire workshop, leading to high system engineering costs. A bigger problem is that receiving material is very time-consuming; each batch of material takes at least three days from entering the freeze dryer to discharging.

[0003] In recent years, with the increasing production capacity of peptide biopharmaceuticals, traditional tray-type vacuum freeze-drying equipment can no longer meet the demands of high production capacity. Existing technologies also include some closed-loop vacuum freeze dryers, such as the internal vacuum single-cone spiral freeze dryer disclosed in patent CN118089340A and the freeze dryer and freeze-drying method disclosed in patent CN116806301A. While these two freeze dryers achieve sealed feeding and discharging, unloading the dried material is still very time-consuming, limiting production to intermittent processes and resulting in less than ideal efficiency. In the freeze dryer and freeze-drying method disclosed in patent CN116806301A, the process material generated during the vacuuming process in the vacuum drying chamber enters the material collector through the top vacuum flow. After secondary drying in the material collector, it falls into the cavity at the bottom of the material collector. Unloading this portion of material requires disassembling the bottom material receiver after each batch of material has dried, emptying it, and then reinstalling it on the material collector, a cumbersome operation. If the material is not removed and unloaded until a production batch is completed or the bottom material receiver is full, materials that are highly susceptible to high temperatures (such as peptide biopharmaceuticals) may be exposed to high temperatures for extended periods, which could affect the efficacy of the peptide biopharmaceuticals.

[0004] In addition, the two sealed drying devices mentioned above only disclose that the bottom of the conical vacuum drying chamber can release materials. However, the release of materials can easily cause dust and debris to fly into the external environment. Furthermore, the material discharge relies solely on its own weight, resulting in a slow discharge speed and incomplete discharge. This leads to a long waiting time in the middle of the conical vacuum drying chamber, which reduces production efficiency.

[0005] Therefore, it is necessary to provide a new continuous dynamic low-temperature freeze-vacuum drying system and production method to solve the above-mentioned technical problems. Summary of the Invention

[0006] The main objective of this invention is to provide a low-temperature freeze-vacuum drying system for continuous dynamic production, which enables dynamic continuous production and rapid automatic feeding of materials and process materials in the vacuum drying chamber, thereby greatly improving production efficiency.

[0007] This invention achieves the above objective through the following technical solution: a continuous dynamic production low-temperature freeze-vacuum drying system, comprising:

[0008] A vacuum freeze-drying production system includes a vacuum drying chamber, a vacuum filter connected to the vacuum drying chamber via a first pipeline, and a vacuum pump group connected to the vacuum filter via a second pipeline; a second control valve is installed on the first pipeline, and a third control valve is installed on the second pipeline.

[0009] The main unloading system includes a discharge buffer chamber, a material collector connected to the bottom of the discharge buffer chamber via a third pipeline, and an induced draft fan connected to the top of the material collector via a fourth pipeline; the discharge buffer chamber is connected to the bottom of the vacuum drying chamber; a fourth control valve is installed on the third pipeline;

[0010] The secondary unloading system includes the vacuum filter, the material collector, the induced draft fan, a fifth pipeline connecting the vacuum filter and the material collector, a fourth pipeline, and a sixth pipeline connecting the induced draft fan and the vacuum filter; a fifth control valve is installed on the fifth pipeline, and a seventh control valve is installed on the sixth pipeline;

[0011] The bottom of the vacuum drying chamber is equipped with a first control valve to control the connection and disconnection between the vacuum drying chamber and the discharge buffer chamber.

[0012] Furthermore, the vacuum drying chamber is provided with a feed inlet and a vacuum interface at the top and a discharge outlet at the bottom; the discharge buffer chamber is located below the discharge outlet and docks with the bottom of the vacuum drying chamber, and the first control valve is located at the discharge outlet; one end of the first pipeline is connected to the vacuum interface; the feed inlet is connected to the material feeding system, and a control valve for controlling the opening and closing is provided on the pipeline connected to the feed inlet.

[0013] Furthermore, the outer peripheral surface of the vacuum drying chamber is covered with a first temperature control jacket, the first temperature control jacket being electrically connected to a temperature controller; a stirring mechanism is provided inside the vacuum drying chamber.

[0014] Furthermore, a vacuum gauge is installed on the second pipeline to monitor the vacuum level in the second pipeline.

[0015] Furthermore, the outer peripheral surface of the vacuum filter is covered with a second temperature control jacket.

[0016] Furthermore, the third pipeline is equipped with a PAT online monitor to monitor the material setting parameters within the third pipeline.

[0017] Furthermore, a first pressure gauge is installed on the sixth pipeline to monitor the pressure inside the sixth pipeline; a second pressure gauge is installed on the fourth pipeline to monitor the pressure inside the fourth pipeline.

[0018] Furthermore, the fifth pipeline and the third pipeline merge into the seventh pipeline and are connected to the material collector, and a sixth control valve is provided on the seventh pipeline to control its opening and closing.

[0019] Furthermore, the exhaust side of the induced draft fan is connected to the discharge buffer chamber via an eighth pipeline, and an eighth control valve is installed on the eighth pipeline.

[0020] Furthermore, a return air filter is also installed on the fourth pipeline.

[0021] Furthermore, the bottom of the material collector is provided with a main discharge control valve; the bottom of the discharge buffer chamber is provided with a discharge port, and an opening valve is provided at the discharge port.

[0022] Another object of the present invention is to provide a production method based on a continuous dynamic production low-temperature freeze-vacuum drying system as described above, comprising the following steps:

[0023] S1. Feeding: In the initial state, all control valves are closed, and the liquid material enters the vacuum drying chamber to achieve automatic feeding;

[0024] S2. Low-temperature stirring: The vacuum drying chamber is cooled down while the material is stirred until the liquid is frozen into the required ice particles by low-temperature stirring.

[0025] S3, Vacuum sublimation drying: The second control valve and the third control valve are opened, the vacuum pump group starts to work, evacuates the vacuum drying chamber, maintains the stirring state, and at the same time, heats the vacuum drying chamber until the material in the vacuum drying chamber becomes the required powder;

[0026] S4. Unloading: The powder in the vacuum drying chamber is quickly unloaded into the discharge buffer chamber; the rapid unloading of the vacuum drying chamber is achieved using either method one or method two.

[0027] Method 1 is as follows: the vacuum drying chamber is de-vacuumed, and after the chamber returns to normal pressure, the first control valve, the fourth control valve, the sixth control valve and the seventh control valve are opened, the third control valve is closed, the second control valve remains open, the induced draft fan is started, and under the action of the induced draft fan, the powder in the vacuum drying chamber is quickly carried into the discharge buffer chamber, and the first control valve is closed after the process is completed.

[0028] Method 2 is as follows: the vacuum drying chamber is de-vacuumed, and after the chamber returns to normal pressure, the first control valve, the fourth control valve, the sixth control valve and the eighth control valve are opened, the second control valve and the third control valve are closed, the induced draft fan is started, and under the action of the induced draft fan, the powder in the vacuum drying chamber is quickly carried into the discharge buffer chamber, and the first control valve is closed after the process is completed.

[0029] S5. Discharge: The fourth control valve, the sixth control valve, and the eighth control valve remain open, and the induced draft fan remains in operation. All the material in the discharge buffer chamber is drawn into the material collector. Then, the fourth control valve, the sixth control valve, and the eighth control valve are closed, and the main discharge control valve at the bottom of the material collector is opened to discharge the material.

[0030] S6. Continuous production of new materials: While step S5 is being executed, new liquid material enters the vacuum drying chamber through the feed port to complete the feeding of new materials. Steps S2 to S4 are repeated to complete the vacuum freeze-drying of the new materials and achieve efficient continuous production.

[0031] Furthermore, step S4 also includes unloading the vacuum filter process;

[0032] The vacuum filter unloading process is as follows: the second control valve and the third control valve are closed, the fifth control valve, the sixth control valve and the seventh control valve are opened, the induced draft fan is started, and the powder material collected in the vacuum filter during the vacuuming process is blown in the opposite direction into the material collector. After the process is completed, the fifth control valve and the seventh control valve are closed.

[0033] Compared with existing technologies, the beneficial effects of the continuous dynamic production low-temperature freeze-drying system and production method of the present invention are: it enables dynamic continuous production, achieves rapid and automatic feeding of materials and process materials in the vacuum drying chamber, and greatly improves production efficiency. Specifically:

[0034] (1) By setting up a vacuum freeze-drying production system, a main unloading system and a secondary unloading system, a low-temperature cold air vacuum drying production system for continuous dynamic production is formed, realizing continuous production and closed production discharge, which improves production efficiency and product quality.

[0035] (2) The vacuum filter in the vacuum freeze-drying production system is equipped with two sets of inlet and outlet interfaces. One set of inlet and outlet interfaces connects the vacuum drying chamber and the vacuum pump group, participates in the vacuuming pipeline, and constitutes the vacuum freeze-drying production system. The other set of inlet and outlet interfaces connects the material collector and the induced draft fan, participates in the secondary unloading system, and realizes the online collection of the material carried out by the steam flow during the vacuuming process and the automated online unloading.

[0036] (3) A discharge buffer chamber is set at the bottom of the vacuum drying chamber and connected to a material collector through a pipeline. The material collector is then connected to an induced draft fan through a pipeline. The induced draft fan quickly draws the dried powder in the vacuum drying chamber into the discharge buffer chamber. After all the material in the vacuum drying chamber has been drawn away, the first control valve at the bottom can be closed to allow the input of the next round of new liquid material, thus achieving uninterrupted continuous production. At the same time, the main unloading system and the secondary unloading system can discharge material synchronously during the next round of new liquid material feeding and low-temperature freeze drying. The vacuum freeze drying production system and the unloading system do not interfere with each other, which greatly improves production efficiency.

[0037] (4) The induced draft fan and the discharge buffer chamber are connected through the seventh pipeline, so that the entire main unloading system forms a sealed circulation system, ensuring that the powder does not need to be exposed to the air during the entire unloading process, thus improving the powder quality. Attached Figure Description

[0038] Figure 1 This is a schematic diagram illustrating the principle structure of an embodiment of the present invention;

[0039] The numbers in the diagram represent:

[0040] 200-Continuous dynamic production low-temperature freeze-vacuum drying system;

[0041] 1-Vacuum drying chamber; 2-Discharge buffer chamber; 3-First pipeline; 4-Vacuum filter; 5-Second pipeline; 6-Vacuum pump unit; 7-Third pipeline; 8-Material collector; 9-Fourth pipeline; 10-Induced draft fan; 11-Fifth pipeline; 12-Sixth pipeline; 13-Inlet; 14-First control valve; 15-Second control valve; 16-Third control valve; 17-Vacuum gauge; 18-Second temperature control jacket; 19-Fourth control valve; 20- PAT online monitor; 21-First pressure gauge; 22-Second pressure gauge; 23-Fifth control valve; 24-Sixth control valve; 25-Eighth pipeline; 26-Eighth control valve; 28-Collection return air filter; 29-Organic solvent collection tank; 30-Main discharge control valve; 31-Seventh control valve; 32-First temperature control jacket; 33-Thermostat; 34-Stirring mechanism; 35-Opening valve; 36-Outlet air pipeline; 37-Ninth control valve. Detailed Implementation

[0042] Example 1:

[0043] Please refer to Figure 1 This embodiment is a continuous dynamic low-temperature freeze-drying system 200, which includes a vacuum drying chamber 1, a discharge buffer chamber 2 located at the bottom of the vacuum drying chamber 1, a vacuum filter 4 connected to the vacuum drying chamber 1 via a first pipe 3, a vacuum pump group 6 connected to the vacuum filter 4 via a second pipe 5, a material collector 8 connected to the bottom of the discharge buffer chamber 2 via a third pipe 7, and an induced draft fan 10 connected to the top of the material collector 8 via a fourth pipe 9. The bottom of the vacuum filter 4 is connected to the material collector via a fifth pipe 11. The blower 10 is connected to the top of the vacuum filter 4 via the sixth pipe 12. The vacuum pump group 6 evacuates the vacuum drying chamber 1 via the second pipe 5, the vacuum filter 4, and the first pipe 3. The blower 10 generates negative pressure in the material collector 8 via the fourth pipe 9, which draws the material in the discharge buffer chamber 2 into the material collector 8 via the third pipe 7. On the other hand, it blows the material adsorbed in the vacuum filter 4 out via the sixth pipe 12 and into the material collector 8 via the fifth pipe 11.

[0044] The vacuum drying chamber 1 has a feed inlet 13 and a vacuum interface (not shown in the figure) at the top, and a discharge port (not shown in the figure) at the bottom. A discharge buffer chamber 2 is located below the discharge port and connects to the bottom of the vacuum drying chamber 1. A first control valve 14 is installed at the discharge port to control its opening and closing. One end of the first pipeline 3 is connected to the vacuum interface, and the other end is connected to a vacuum filter 4. The feed inlet 13 is connected to the material feeding system, and a control valve is installed on the pipeline connecting to the feed inlet 13 to control its opening and closing. The vacuum drying chamber 1 is also equipped with a breather valve (not shown in the figure) for vacuum depressurization, converting the vacuum pressure environment to an atmospheric pressure environment.

[0045] The outer surface of the vacuum drying chamber 1 is covered with a first temperature control jacket 32. The first temperature control jacket 32 ​​is electrically connected to a temperature controller 33. The temperature controller 33 controls the temperature of the circulating medium inside the first temperature control jacket 32 ​​to perform cooling or heating operations on the vacuum drying chamber 1.

[0046] The vacuum drying chamber 1 is equipped with a stirring mechanism 34, which stirs the material in the vacuum drying chamber 1 in a spiral up-and-down tumbling motion.

[0047] A second control valve 15 is installed on the first pipeline 3 to control the opening and closing of the first pipeline 3, thereby controlling the connection and disconnection between the vacuum drying chamber 1 and the vacuum filter 4. A third control valve 16 is installed on the second pipeline 5 to control the opening and closing of the second pipeline 5, and a vacuum gauge 17 is installed to monitor the vacuum level in the second pipeline 5. The third control valve 16 controls the connection and disconnection between the vacuum filter 4 and the vacuum pump assembly 6. The vacuum gauge 17 monitors the vacuum level in the second pipeline 5, and the start and stop of the vacuum pump assembly 6 can be controlled according to process requirements.

[0048] The outer peripheral surface of the vacuum filter 4 is covered with a second temperature control jacket 18. When the dryness of the material adsorbed in the vacuum filter 4 is insufficient, the second temperature control jacket 18 can be opened to heat up and dry the material in the vacuum filter 4.

[0049] The third pipeline 7 is equipped with a fourth control valve 19 for controlling the opening and closing of the third pipeline 7, and a PAT online monitor 20 for monitoring the set parameters of the material in the third pipeline 7. The PAT online monitor 20 can monitor the concentration, temperature, dryness, composition, etc. of the material in the third pipeline 7 as needed. The fourth control valve 19 controls the connection and disconnection between the discharge buffer chamber 2 and the material collector 8.

[0050] A first pressure gauge 21 is installed on the sixth pipeline 12 to monitor the pressure inside the sixth pipeline 12. A second pressure gauge 22 is installed on the fourth pipeline 9 to monitor the pressure inside the fourth pipeline 9.

[0051] A fifth control valve 23 is installed on the fifth pipeline 11 to control its opening and closing. The fifth control valve 23 controls the connection and disconnection between the vacuum filter 4 and the material collector 8. The fifth pipeline 11 and the third pipeline 7 merge into the seventh pipeline (not shown in the figure) and then connect to the material collector 8. A sixth control valve 24 is installed on the seventh pipeline to control its opening and closing. The sixth control valve 24 controls the opening and closing state of the input port of the material collector 8.

[0052] A seventh control valve 31 is installed on the sixth pipeline 12 to control the opening and closing of the sixth pipeline 12. The seventh control valve 31 controls the conduction and blocking between the vacuum filter 4 and the induced draft fan 10.

[0053] The exhaust side of the induced draft fan 10 is connected to the discharge buffer chamber 2 via an eighth pipe 25, and an eighth control valve 26 is installed on the eighth pipe 25. The eighth pipe 25 serves as the exhaust pipe for the induced draft fan 10 and is also connected to the discharge buffer chamber 2, forming a closed internal circulation system. This ensures that the material remains isolated from the outside environment during transfer within the internal pipes, preventing contamination and leakage that could affect the workshop environment. The output side of the induced draft fan 10 also has an exhaust pipe 36 connected to the outside, and a ninth control valve 37 is installed on the exhaust pipe 36. The exhaust pipe 36 can be opened when the internal pipes of the vacuum drying system need to be dried after cleaning.

[0054] During the internal pipeline drying process, there are two drying paths. One drying path is as follows: outside air enters the vacuum drying chamber 1 from the feed inlet 13, then passes through the first pipeline 3, vacuum filter 4, fifth pipeline 11, material collector 8, and fourth pipeline 9, and is discharged from the exhaust pipeline 36 under the suction of the induced draft fan 10. The other drying path is as follows: outside air enters the vacuum drying chamber 1 from the feed inlet 13, then passes through the discharge buffer chamber 2, third pipeline 7, material collector 8, and fourth pipeline 9, and is discharged from the exhaust pipeline 36 under the suction of the induced draft fan 10.

[0055] The fourth pipe 9 is also equipped with a return air filter 28 to filter out the gas and liquid in the air inside the fourth pipe 9, preventing it from entering the induced draft fan 10 and damaging the induced draft fan 10.

[0056] An organic solvent collection tank 29 is also provided on the air outlet side of the vacuum pump unit 6.

[0057] The bottom of the material collector 8 is equipped with a discharge control valve 30.

[0058] The bottom of the discharge buffer chamber 2 is provided with a discharge port, and an opening valve 35 is provided at the discharge port. The opening valve 35 can be opened for use when rapid discharge is required in the event of cleaning, equipment failure, or abnormality.

[0059] This embodiment describes a production method for a continuously dynamic low-temperature freeze-vacuum drying system, which includes the following steps:

[0060] S1. Feeding: In the initial state, all control valves are closed. The liquid enters the vacuum drying chamber 1 through the feed port 13 to achieve automatic feeding. When the feed reaches the set amount, the control valve at the feed port 13 is closed.

[0061] S2. Low-temperature stirring: The temperature controller 33 controls the temperature of the first temperature control jacket 32 ​​to cool down the vacuum drying chamber 1. At the same time, the stirring mechanism 34 stirs the material according to the set speed until the liquid is frozen into the required ice particles by low-temperature stirring.

[0062] S3, Vacuum sublimation drying: The second control valve 15 and the third control valve 16 are opened, the vacuum pump group 6 starts to work, and the vacuum drying chamber 1 is evacuated. The stirring mechanism 34 keeps stirring. At the same time, the temperature controller 33 controls the temperature of the first temperature control jacket 32 ​​to heat up the vacuum drying chamber 1 until the material in the vacuum drying chamber 1 becomes the required powder.

[0063] S4. Unloading: This includes rapid unloading from vacuum drying chamber 1 and process unloading from vacuum filter 4. The two unloading processes are performed sequentially, but there is no strict order. Alternatively, vacuum filter 4 may perform process unloading only after vacuum drying chamber 1 has completed a set number of rapid unloading cycles.

[0064] There are two methods for rapid unloading of vacuum drying chamber 1:

[0065] Method 1: Open the breather valve on the vacuum drying chamber 1 to release the vacuum and wait for the pressure inside the chamber to return to normal. Then, open the first control valve 14, the fourth control valve 19, the sixth control valve 24, and the seventh control valve 31. Close the third control valve 16 and keep the second control valve 15 open. Start the induced draft fan 10. Under the action of the induced draft fan 10, positive pressure is applied to the inside of the vacuum drying chamber 1 on the one hand, and negative pressure is formed in the discharge buffer chamber 2 on the other hand, which quickly carries the powder in the vacuum drying chamber 1 into the discharge buffer chamber 2. After the process is completed, close the first control valve 14.

[0066] Method 2: Open the breather valve on the vacuum drying chamber 1 to release the vacuum. After the pressure inside the chamber returns to normal, open the first control valve 14, the fourth control valve 19, the sixth control valve 24 and the eighth control valve 26, close the second control valve 15 and the third control valve 16, and start the induced draft fan 10. Under the action of the induced draft fan 10, a negative pressure suction is formed in the discharge buffer chamber 2, which quickly draws the powder in the vacuum drying chamber 1 into the discharge buffer chamber 2. After the process is completed, close the first control valve 14 to complete the rapid unloading of the material in the vacuum drying chamber 1.

[0067] Vacuum filter 4 process unloading: Second control valve 15 and third control valve 16 are closed, fifth control valve 23, sixth control valve 24 and seventh control valve 31 are opened, induced draft fan 10 is started, and the powder material collected in the vacuum filter 4 during the vacuuming process is blown in the opposite direction into the material collector 8. After the process is completed, fifth control valve 23 and seventh control valve 31 are closed.

[0068] When the vacuum drying chamber 1 is evacuated, the vapor flow carries some liquid material into the vacuum filter 4, where it is intercepted. The liquid material is then heated by the second temperature control jacket 18 on the outer periphery of the vacuum filter 4, resulting in powder. Once the liquid material in the vacuum drying chamber 1 is completely dried into powder, the second control valve 15 and the third control valve 16 are closed to isolate the vacuum filter 4 from the vacuum drying chamber 1 and the vacuum pump group 6. The fifth control valve 23, the sixth control valve 24, and the seventh control valve 31 are opened to connect the blower 10, the vacuum filter 4, and the material collector 8. The blower 10 blows the process material collected by the vacuum filter 4 into the material collector 8, thus unloading the process material. This achieves automatic unloading of the process material and effectively prevents the process material from being heated for too long in the vacuum filter 4, which could affect the drug activity.

[0069] S5. Discharge: The fourth control valve 19, the sixth control valve 24, and the eighth control valve 26 remain open, and the induced draft fan 10 remains in operation. All the material in the discharge buffer chamber 2 is drawn into the material collector 8. Then, the fourth control valve 19, the sixth control valve 24, and the eighth control valve 26 are closed, and the discharge main control valve 30 at the bottom of the material collector 8 is opened for continuous online discharge. Bottled or bagged discharge packaging operations can be performed at the output end of the discharge main control valve 30.

[0070] S6. Continuous production of new materials: While step S5 is being executed, new liquid material enters the vacuum drying chamber 1 through the feed port 13 to complete the feeding of new materials. Steps S2 to S4 are repeated to complete the vacuum freeze-drying of the new materials and achieve efficient continuous production.

[0071] In this embodiment, the vacuum drying chamber 1, the first pipeline 3, the vacuum filter 4, the second pipeline 5, and the vacuum pump group 6 together form a vacuum freeze-drying production system; the discharge buffer chamber 2, the third pipeline 7, the material collector 8, the fourth pipeline 9, and the induced draft fan 10 together form a main unloading system; the vacuum filter 4, the fifth pipeline 11, the material collector 8, the fourth pipeline 9, the induced draft fan 10, and the sixth pipeline 12 together form a secondary unloading system; after all the powder in the vacuum drying chamber 1 and the vacuum filter 4 has been unloaded, the first control valve 14, the fifth control valve 23, and the seventh control valve 31 are closed, which ensures the independence of the vacuum freeze-drying production system. Furthermore, during the discharge process, the vacuum freeze-drying production system can simultaneously perform vacuum freeze-drying of new liquid material, greatly reducing the discharge waiting time, achieving continuous production, and improving production efficiency.

[0072] In this embodiment, the entire material drying process, unloading process, and discharge process are completed in a closed pipeline system, eliminating the need for external crushing and reducing the contact between powder and outside air, thus improving product quality. At the same time, it also reduces the cleanliness requirements of the production workshop and lowers production costs.

[0073] The above descriptions are merely some embodiments of the present invention. Those skilled in the art can make various modifications and improvements without departing from the inventive concept of the present invention, and these all fall within the scope of protection of the present invention.

Claims

1. A production method of a low-temperature freeze vacuum drying system based on continuous dynamic production, characterized by: Comprise: Continuous dynamic production of low-temperature frozen vacuum drying system, the continuous dynamic production of low-temperature frozen vacuum drying system comprises: Vacuum freeze drying production system, the vacuum freeze drying production system comprises a vacuum drying cabin (1), a vacuum filter (4) communicated with the vacuum drying cabin (1) through a first pipeline (3), a vacuum pump group (6) communicated with the vacuum filter (4) through a second pipeline (5); The first pipeline (3) is provided with a second control valve (15), and the second pipeline (5) is provided with a third control valve (16); Main discharge system, the main discharge system comprises a discharge buffer cabin (2), a material collector (8) communicated with the bottom of the discharge buffer cabin (2) through a third pipeline (7), and an air blower (10) communicated with the top of the material collector (8) through a fourth pipeline (9); The discharge buffer cabin (2) is arranged at the bottom of the vacuum drying cabin (1); The third pipeline (7) is provided with a fourth control valve (19); Secondary discharge system, the secondary discharge system comprises the vacuum filter (4), the material collector (8), the air blower (10), the fifth pipeline (11) communicated with the vacuum filter (4) and the material collector (8), the fourth pipeline (9) and the sixth pipeline (12) communicated with the air blower (10) and the vacuum filter (4); The fifth pipeline (11) is provided with a fifth control valve (23), and the sixth pipeline (12) is provided with a seventh control valve (31); The bottom of the vacuum drying cabin (1) is provided with a first control valve (14), which controls the conduction and blockage between the vacuum drying cabin (1) and the discharge buffer cabin (2); The fifth pipeline (11) and the third pipeline (7) are connected to the material collector (8) through the seventh pipeline, and a sixth control valve (24) is arranged on the seventh pipeline to control the opening and closing thereof; The air outlet side of the air blower (10) is communicated with the discharge buffer cabin (2) through an eighth pipeline (25), and an eighth control valve (26) is arranged on the eighth pipeline (25); The production method of the continuous dynamic production based low-temperature frozen vacuum drying system comprises the following steps: S1, feeding: in the initial state, all control valves are closed, the liquid enters the vacuum drying cabin (1), and automatic feeding is realized; S2, low-temperature stirring: the vacuum drying cabin (1) is cooled, and the material is stirred until the liquid is frozen into ice particles by low-temperature stirring; S3, vacuum sublimation drying: the second control valve (15) and the third control valve (16) are opened, the vacuum pump group (6) starts to work, the vacuum drying cabin (1) is vacuumized, the stirring state is maintained, and the vacuum drying cabin (1) is heated until the material in the vacuum drying cabin (1) becomes the required powder; S4, discharging: the vacuum drying cabin is quickly discharged, and the powder in the vacuum drying cabin (1) is quickly discharged into the discharge buffer cabin (2); The vacuum drying cabin rapid discharging is realized by mode one or mode two; The mode one is that the vacuum drying cabin (1) is depressurized, the first control valve (14), the fourth control valve (19), the sixth control valve (24) and the seventh control valve (31) are opened after the cabin restores to normal pressure, the third control valve (16) is closed, the second control valve (15) remains in the opened state, the air drafter (10) is started, the powder in the vacuum drying cabin (1) is rapidly taken into the discharging buffer cabin (2) under the action of the air drafter (10), and then the first control valve (14) is closed; The mode two is that the vacuum drying cabin (1) is depressurized, the first control valve (14), the fourth control valve (19), the sixth control valve (24) and the eighth control valve (26) are opened after the cabin restores to normal pressure, the second control valve (15) and the third control valve (16) are closed, the air drafter (10) is started, the powder in the vacuum drying cabin (1) is rapidly taken into the discharging buffer cabin (2) under the action of the air drafter (10), and then the first control valve (14) is closed; S5, discharging: the fourth control valve (19), the sixth control valve (24) and the eighth control valve (26) remain in the opened state, the air drafter (10) remains in the working state, the material in the discharging buffer cabin (2) is all taken into the material collector (8), then the fourth control valve (19), the sixth control valve (24) and the eighth control valve (26) are closed, and the discharging total control valve (30) at the bottom of the material collector (8) is opened to discharge; S6, new material continuous production: while the step S5 is performed, new material liquid enters the vacuum drying cabin (1) through the feeding port (13) to complete new material feeding, the steps S2 to S4 are repeated, new material vacuum freeze drying is completed, and high-efficiency continuous production is realized; The step S4 further includes a vacuum filter process discharging; The vacuum filter process discharging includes that the second control valve (15) and the third control valve (16) are closed, the fifth control valve (23), the sixth control valve (24) and the seventh control valve (31) are opened, the air drafter (10) is started, the powder material collected in the vacuum filter (4) in the vacuumizing process is reversely blown into the material collector (8), and then the fifth control valve (23) and the seventh control valve (31) are closed.

2. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The top of the vacuum drying cabin (1) is provided with a feeding port (13) and a vacuumizing interface, and the bottom is provided with a discharging port; the discharging buffer cabin (2) is arranged below the discharging port and is connected with the bottom of the vacuum drying cabin (1), the first control valve (14) is arranged at the discharging port; one end of the first pipeline (3) is communicated with the vacuumizing interface; the feeding port (13) is communicated with a material feeding system, and a control valve for controlling opening and closing is arranged on a pipeline communicated with the feeding port (13).

3. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The outer circumferential surface of the vacuum drying cabin (1) is provided with a first temperature control jacket (32), and the first temperature control jacket (32) is in circuit communication with a temperature controller; the vacuum drying cabin (1) is provided with a stirring mechanism (34).

4. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The second pipeline (5) is provided with a vacuum gauge (17) for monitoring the vacuum degree in the second pipeline (5).

5. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The outer circumferential surface of the vacuum filter (4) is provided with a second temperature control jacket (18).

6. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The third pipeline (7) is provided with a PAT online monitor (20) for monitoring the material setting parameters in the third pipeline (7).

7. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The sixth pipeline (12) is provided with a first pressure gauge (21) for monitoring the pressure in the sixth pipeline (12); and the fourth pipeline (9) is provided with a second pressure gauge (22) for monitoring the pressure in the fourth pipeline (9).

8. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The fourth pipeline (9) is further provided with a collection return air filter (28).

9. The continuously dynamically produced cryogenic freeze vacuum drying system of claim 1, wherein: The bottom of the material collector (8) is provided with a total discharge control valve (30); and the bottom of the discharge buffer cabin (2) is provided with a discharge port, and the discharge port is provided with an opening valve (35).

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