An immunological analyzer displacement device

Abstract

The present invention discloses a displacement device for an immunoassay analyzer, belonging to the technical field of biological detection. The device includes a reaction disk housing, a reaction disk rotatably connected to the reaction disk housing, and a driving assembly for driving the reaction disk to rotate relative to the reaction disk housing. The device further includes: a device base detachably connected to the reaction disk housing; a pushing mechanism installed on the device base for pushing reaction cups to a placement mechanism installed on the reaction disk; a feeding mechanism installed on the device base for transporting reaction cups to the pushing mechanism for transportation processing; and a placement mechanism installed on the reaction disk for placing and processing reaction cups. In the present invention, the loading position and the unloading position of the reaction cups are integrated into one place. When loading new reaction cups, the unloading of the old reaction cups can be completed smoothly.

Description

Technical Field

[0001] The present invention belongs to the technical field of biological detection, and particularly relates to a reaction cup displacement device for an immunoassay analyzer. Background Art

[0002] At present, in vitro diagnosis is one of the most commonly used diagnostic methods in the medical field. According to the detection principle or method, in vitro diagnosis is mainly divided into biochemical diagnosis, immunoassay diagnosis, molecular diagnosis, microbial diagnosis, urine diagnosis, coagulation diagnosis, blood and flow cytometry diagnosis, etc. Among them, biochemical and immunoassay are the main methods of in vitro diagnosis in China at present. These diagnostic methods all use fully automatic or semi-automatic instruments for sample addition, analysis and generation of diagnostic reports.

[0003] During the test, reaction cups are needed to contain reaction reagents and body fluid samples and mix them. After reacting for a period of time in a heating and insulation environment, the reaction cups are transported to the detection position for photoelectric conversion detection.

[0004] Immunoassay analyzers often use disposable reaction cups. As test consumables, reaction cups need to be replenished and removed (loaded and unloaded). Usually, reaction cups are placed in the reaction cup accommodation grooves distributed along the circumference of the reaction disk. Limited by the diameter ratio of the reaction cup and the reaction disk, the number of reaction cups that can be accommodated by a single-row arranged reaction disk is limited. To increase the number of reaction cups, the diameter of the reaction disk also needs to be made larger, which is not conducive to the miniaturization of the device.

[0005] In addition, a manipulator or other mechanism is needed to automatically load and unload the reaction cups. Therefore, it is necessary to design a reaction cup displacement device with a small structure, fast movement and low cost to realize the automatic loading and unloading of the reaction cups.

[0006] Furthermore, high-speed immunoassay analyzers require an efficient detection rhythm, while the reaction disk has a large inertia, and each start and stop will affect the test speed. The loading position and discarding position of the reaction cups of common devices are separately arranged, which not only makes the mechanism complex and repeated, increases the volume and cost of the device, but also reduces the operation efficiency. Summary of the Invention

[0007] Aiming at the deficiencies of the prior art, the present invention provides a reaction cup displacement device for an immunoassay analyzer, which solves the above problems.

[0008] To achieve the above object, the present invention is realized through the following technical solutions: A reaction cup displacement device for an immunoassay analyzer includes a reaction disk housing, a reaction disk rotatably connected to the reaction disk housing, and a driving component for driving the reaction disk to rotate relative to the reaction disk housing, and further includes:

[0009] A device base detachably connected to the reaction disk housing;

[0010] A pushing mechanism, installed on the device base, for pushing reaction cups to a placement mechanism installed on a reaction disc;

[0011] A feeding mechanism, installed on the device base, for transporting reaction cups to the pushing mechanism for transfer processing;

[0012] A placement mechanism, installed on the reaction disc, for placing reaction cups;

[0013] Among them, the placement mechanism includes a strip slot and a circular slot. The strip slot penetrates the circular slot, and both the strip slot and the circular slot are opened on the reaction disc;

[0014] The pushing mechanism includes a stepper motor, a spur gear, and a rack. The stepper motor is detachably connected to the device base. The spur gear fixedly connected to the output shaft of the stepper motor meshes with the rack. The rack is slidably matched with a guide rail detachably installed on the device base. The end of the rack close to the reaction disc housing is detachably connected with a mounting seat. A push-pull electromagnet is installed on the mounting seat. A photoelectric switch is detachably installed on one side of the device base. A chopping light sheet is arranged above the rack and the chopping light sheet is detachably connected to the device base.

[0015] Based on the above technical solutions, the present invention also provides the following optional technical solutions:

[0016] Further technical solution: The strip slots and the circular slots, which are provided in several groups in one-to-one correspondence, are evenly distributed in a ring shape on it. A discard pipe for cooperating with the circular slot to recycle the reaction cup is fixedly connected to the reaction disc housing.

[0017] Further technical solution: The feeding mechanism includes a slope platform. The slope platform is detachably connected to the side of the device base. Slide rails for the reaction cup to slide are opened on both the slope platform and the device base. The cross section of the slide rail is T-shaped and the two slide rails communicate with each other.

[0018] Further technical solution: The reaction disc housing is provided with a feeding port for guiding the reaction cup into the strip slot in cooperation with the slide rail. The slide rail provided on the slope platform is in a slope shape.

[0019] Further technical solution: It further includes an adjustment and evaluation system for regulating the pushing mechanism and the push-pull electromagnet and evaluating the operating state of the device.

[0020] Further technical solution: The adjustment and evaluation system includes:

[0021] A speed detection unit, used to detect the movement speed of the push-pull electromagnet, which is a speed sensor;

[0022] A displacement detection unit, which is used to detect the displacement distance of the movable iron core column in the push-pull electromagnet and is a distance sensor;

[0023] A storage module, which is used to store the data detected by the speed detection unit and the displacement detection unit and establish a data set;

[0024] A threshold module, which is used to retrieve the motion speed information of the push-pull electromagnet at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet at the current moment from the storage module, compare the two with the preset thresholds, and judge whether at least one of the speed information and the displacement information exceeds the corresponding preset thresholds. If at least one of them exceeds the corresponding preset thresholds, judgment information for controlling the stepping motor or the push-pull electromagnet is formed;

[0025] An analysis module, which is used to retrieve the motion speed information of the push-pull electromagnet at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet at the current moment from the storage module to form a predicted value, compare the predicted value with the preset prediction threshold, form judgment information for controlling the stepping motor or the push-pull electromagnet, and at the same time correlate the predicted values formed by the speed information and the displacement information to form an evaluation coefficient, and compare the formed evaluation coefficient with the preset evaluation threshold to form judgment information for controlling the stepping motor or the push-pull electromagnet;

[0026] A control module, which is used to receive the judgment information and control the stepping motor and the push-pull electromagnet according to the judgment information;

[0027] A warning module, which performs warning processing according to the judgment information received by the control module.

[0028] A further technical solution: The specific processing method of the analysis module is as follows:

[0029] S1. Obtain the speed information and displacement information at the current moment from the data set of the storage module, denoted as V 1 、V 2 , ... , V i-1 , S 1 、S 2 , ... , S i-1 ;

[0030] S2. Through linear regression, predict the speed information and speed information and displacement at the next moment, and respectively obtain the predicted values V i and S i, and compare it with the corresponding velocity threshold and displacement threshold. If the predicted value V i and S i If any one of the speed threshold and the temperature threshold is greater than the corresponding one, the judgment information for controlling the stepper motor or the push-pull electromagnet is formed;

[0031] S3. Based on the predicted value, t The predicted value formed by the speed information at the moment (that is, the next moment) and the displacement information is associated to form an adjustment coefficient, and the expression of the adjustment coefficient is:

[0032] ;

[0033] in, represents the adjustment coefficient, represents the speed prediction value, represents the displacement prediction value, Indicates the influence factor of the reaction cup material. When the reaction cup material is polystyrene, , when the reaction cup is made of polycarbonate, , Indicates the number of items;

[0034] S4, comparing the obtained adjustment evaluation coefficient with a preset adjustment evaluation coefficient threshold to form a comparison result. If the adjustment evaluation coefficient is greater than the preset threshold, judgment information for controlling the stepping motor and the push-pull electromagnet is formed;

[0035] S5. Transmit the above-formed judgment information to the control module for related module control.

[0036] The present invention provides an immunoassay analyzer displacement device, which has the following beneficial effects compared with the prior art:

[0037] The present invention integrates the reaction cup loading position and the unloading position into one place. When a new reaction cup is loaded, the old reaction cup is unloaded and enters the waste recovery pipeline for recovery, which saves the start and stop time of the reaction disk and the overall manufacturing cost, and makes the structure more compact. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention.

[0039] Figure 2 It is a structural schematic diagram of the pushing mechanism of the present invention.

[0040] Figure 3 It is a structural schematic diagram of the placement mechanism of the present invention.

[0041] Figure 4This is a partial structural schematic diagram of the placement mechanism of the present invention.

[0042] Figure 5 This is a structural schematic diagram of the feeding mechanism of the present invention.

[0043] Figure 6 This is a structural schematic diagram of the feeding mechanism of the present invention from another angle.

[0044] Annotation of reference numerals: 1. Reaction disk housing; 2. Reaction disk; 3. Device base; 4. Pushing mechanism; 401. Stepper motor; 402. Flat gear; 403. Rack; 404. Beam splitter; 405. Push-pull electromagnet; 406. Photoelectric switch; 407. Guide rail; 5. Feeding mechanism; 501. Slope platform; 502. Slide rail; 6. Placement mechanism; 601. Strip-shaped slot; 602. Circular slot; 603. Discarding pipe; 7. Reaction cup. Detailed implementation manners

[0045] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0046] The following describes the specific implementation of the present invention in detail with reference to specific embodiments.

[0047] Please refer to Figures 1 to 6 , a displacement device for an immunoassay analyzer provided by an embodiment of the present invention, includes a reaction disk housing 1, a reaction disk 2 rotatably connected to the reaction disk housing 1, and a driving assembly (not marked in the figure, which is prior art and will not be elaborated) for driving the reaction disk 2 to rotate relative to the reaction disk housing 1, and further includes:

[0048] A device base 3, detachably connected to the reaction disk housing 1;

[0049] A pushing mechanism 4, installed on the device base 3, for pushing the reaction cup 7 to the placement mechanism 6 installed on the reaction disk 2;

[0050] A feeding mechanism 5, installed on the device base 3, for transporting the reaction cup 7 to the pushing mechanism 4 for transfer processing;

[0051] A placement mechanism 6, installed on the reaction disk 2, for placing the reaction cup 7;

[0052] Among them, the placement mechanism 6 includes a strip-shaped slot 601 and a circular slot 602. The strip-shaped slot 601 penetrates the circular slot 602, and both the strip-shaped slot 601 and the circular slot 602 are opened on the reaction disk 2. A plurality of groups of the strip-shaped slots 601 and the circular slots 602, which are arranged in one-to-one correspondence, are evenly distributed in a ring on the upper part. A discard pipe 603 for cooperating with the circular slot 602 to recycle the reaction cup 7 is fixedly connected to the reaction disk housing 1;

[0053] Among them, the pushing mechanism 4 includes a stepping motor 401, a spur gear 402 and a rack 403. The stepping motor 401 is detachably connected to the device base 3. The spur gear 402 fixedly connected to the output shaft of the stepping motor 401 meshes with the rack 403. The rack 403 is slidably matched with a guide rail 407 detachably installed on the device base 3. An end of the rack 403 close to the reaction disk housing 1 is detachably connected to a mounting seat (not marked in the figure). A push-pull electromagnet 405 is installed on the mounting seat. A photoelectric switch 406 is detachably installed on one side of the device base 3. A chopping blade 404 is arranged above the rack 403, and the chopping blade 404 is detachably connected to the device base 3;

[0054] Among them, the feeding mechanism 5 includes a slope platform 501. The slope platform 501 is detachably connected to the side of the device base 3. Slide rails 502 for the reaction cup 7 to slide are opened on both the slope platform 501 and the device base 3. The cross section of the slide rail 502 is T-shaped and the two slide rails 502 communicate with each other. A feed inlet (not marked in the figure) for cooperating with the slide rail 502 to guide the reaction cup 7 into the strip-shaped slot 601 is opened on the reaction disk housing 1. The slide rail 502 opened on the slope platform 501 is in a slope shape.

[0055] In the embodiment of the present invention, the external cup supply mechanism automatically supplies the reaction cup on the slide rail 502, and the reaction cup 7 slides down to the bottom of the push-pull electromagnet 405 under the action of its own gravity. The push-pull electromagnet 405 is started, and the push-pull electromagnet 405 extends the movable iron core column into one or two reaction cups 7 accordingly. At this time, the stepper motor 401 is started to drive the flat gear 402 to perform a rotational movement in the vertical direction. The flat gear 402 drives the mounting seat to perform a linear movement in the horizontal direction by pushing the rack 403 meshing with it. The mounting seat synchronously drives the push-pull electromagnet 405 to perform a linear movement, and the push-pull electromagnet 405 extends one or two reaction cups 7. The reaction cup 7 is pushed into the strip slot 601. If there is a reaction cup 7 in the corresponding strip slot 601, the reaction cup 7 will be pushed into the circular slot 602 by the newly entered reaction cup 7 and fall into the discard tube 603 for recovery through the guidance of the circular slot 602, thereby realizing rapid loading and disassembly of the reaction cup 7 and the loading and disassembly can be completed synchronously. The push-pull electromagnet 405 can constitute a toggle mechanism, which can be quickly extended or retracted, replacing the lifting mechanism, and the compound action is more diversified. The reaction disk with a multi-ring arrangement increases the capacity of the reaction disk, and the reaction cup loading and unloading positions are combined, the structure is compact, and the action rhythm is more efficient.

[0056] As an embodiment of the present invention, it also includes an adjustment and evaluation system for adjusting the pushing mechanism 4 and the push-pull electromagnet 405 and evaluating the operating state of the device, and the adjustment and evaluation system includes:

[0057] The speed detection unit is used to detect the movement speed of the push-pull electromagnet 405 and is a speed sensor;

[0058] The displacement detection unit is used to detect the displacement distance of the movable iron core column in the push-pull electromagnet 405, and is a distance sensor;

[0059] A storage module, used to store the data detected by the speed detection unit and the displacement detection unit and to establish a data set;

[0060] A threshold module is used to retrieve the movement speed information of the push-pull electromagnet 405 at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet 405 at the current moment in the storage module, compare the two with the preset threshold, and determine whether at least one of the speed information and the displacement information exceeds the corresponding preset threshold. If at least one of them exceeds the corresponding preset threshold, the determination information for controlling the stepping motor 401 or the push-pull electromagnet 405 is formed;

[0061] An analysis module, configured to retrieve the motion speed information of the push-pull electromagnet 405 at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet 405 at the current moment from the storage module to form a predicted value, compare the predicted value with a preset prediction threshold to form judgment information for controlling the stepper motor 401 or the push-pull electromagnet 405, and at the same time correlate the predicted values formed by the speed information and the displacement information to form an evaluation coefficient, and compare the formed evaluation coefficient with a preset evaluation threshold to form judgment information for controlling the stepper motor 401 or the push-pull electromagnet 405;

[0062] A control module, configured to receive the judgment information and control the stepper motor 401 and the push-pull electromagnet 405 according to the judgment information;

[0063] A warning module, configured to perform warning processing according to the judgment information received by the control module;

[0064] The specific processing method of the analysis module is as follows:

[0065] S1. Obtain the current moment speed information and displacement information from the dataset of the storage module, denoted as V 1 、V 2 , ... , V i-1 , S 1 、S 2 , ... , S i-1 ;

[0066] S2. Through linear regression, predict the speed information and displacement at the next moment, and respectively obtain the predicted values V i and S i , and compare them with the corresponding speed threshold and displacement threshold. If any of the predicted values V i and S i is greater than the corresponding speed threshold and temperature threshold, form judgment information for controlling the stepper motor 401 or the push-pull electromagnet 405;

[0067] S3. Based on the predicted value, correlate the predicted values of the speed information and displacement information at the moment (i.e., the next moment) to form an evaluation coefficient. The expression of the evaluation coefficient is: t

[0068] ; ​

[0069] Among them, represents the adjustment evaluation coefficient, represents the speed prediction value, represents the displacement prediction value, represents the material influence factor of reaction cup 7. When the material of reaction cup 7 is polystyrene, , when the material of reaction cup 7 is polycarbonate, , represents the number of items;

[0070] S4. Compare the obtained adjustment evaluation coefficient with the preset adjustment evaluation coefficient threshold to form a comparison result. If the adjustment evaluation coefficient is greater than the preset threshold, then form the judgment information for controlling the stepper motor 401 and the push-pull electromagnet 405;

[0071] S5. Transmit the above-mentioned formed judgment information to the control module for controlling related modules.

[0072] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variant thereof are intended to cover non-exclusively, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or device.

[0073] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A displacement device for an immunoassay analyzer, comprising a reaction disk housing (1), a reaction disk (2) rotatably connected to the reaction disk housing (1), and a driving assembly for driving the reaction disk (2) to rotate relative to the reaction disk housing (1), characterized in that: Also includes: A device base (3) is detachably connected to the reaction disk housing (1); A pushing mechanism (4) is mounted on the device base (3) and is used to push the reaction cup (7) onto the placement mechanism (6) mounted on the reaction disk (2); A feeding mechanism (5) is installed on the device base (3) and is used to transfer the reaction cup (7) to the pushing mechanism (4) for transfer processing; A placement mechanism (6) is installed on the reaction disk (2) and is used to place the reaction cup (7); The placement mechanism (6) comprises a strip-shaped slot (601) and a circular slot (602), the strip-shaped slot (601) passes through the circular slot (602), and both the strip-shaped slot (601) and the circular slot (602) are arranged on the reaction disk (2); The pushing mechanism (4) comprises a stepping motor (401), a spur gear (402) and a rack (403); the stepping motor (401) is detachably connected to the device base (3); the spur gear (402) fixedly connected to the output shaft of the stepping motor (401) meshes with the rack (403); the rack (403) is slidably matched with a guide rail (407) detachably mounted on the device base (3); an end of the rack (403) close to the reaction disk housing (1) is detachably connected to a mounting seat; a push-pull electromagnet (405) is mounted on the mounting seat; a photoelectric switch (406) is detachably mounted on one side of the device base (3); a chopper (404) is arranged above the rack (403) and the chopper (404) is detachably connected to the device base (3); It also includes an adjustment and evaluation system for adjusting the pushing mechanism (4) and the push-pull electromagnet (405) and evaluating the operating state of the device, including: An analysis module, used to form a prediction value based on the movement speed information of the push-pull electromagnet (405) in the data set acquired at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet (405) at the current moment, and compare the prediction value with a preset prediction threshold value to form judgment information for controlling the stepping motor (401) or the push-pull electromagnet (405), and at the same time associate the prediction value formed by the speed information and the displacement information to form an adjustment evaluation coefficient, and compare the formed adjustment evaluation coefficient with the preset adjustment evaluation threshold value to form judgment information for controlling the stepping motor (401) or the push-pull electromagnet (405); The specific processing method of the analysis module is: S1. Obtain the velocity information and displacement information of the current data set, recorded as V 1 、V 2 , ... , V i-1 , S 1 、S 2 , ... , S i-1 ; S2. Predict the speed information, speed information and displacement at the next moment by linear regression, and obtain the predicted values ​​respectively. V i and S i , and compare it with the corresponding velocity threshold and displacement threshold. If the predicted value V i and S i If any one of the speed threshold and the temperature threshold is greater than the corresponding one, judgment information for controlling the stepping motor (401) or the push-pull electromagnet (405) is formed; S3. Based on the predicted value, t The predicted value formed by the speed information and the displacement information at the moment is associated to form an adjustment coefficient, and the expression of the adjustment coefficient is: ； in, represents the adjustment coefficient, represents the speed prediction value, represents the displacement prediction value, represents the influence factor of the material of the reaction cup (7). When the material of the reaction cup (7) is polystyrene, When the reaction cup (7) is made of polycarbonate, , Indicates the number of items; S4, comparing the obtained adjustment evaluation coefficient with a preset adjustment evaluation coefficient threshold to form a comparison result, and if the adjustment evaluation coefficient is greater than the preset threshold, forming judgment information for controlling the stepping motor (401) and the push-pull electromagnet (405); S5. Transmit the above-formed judgment information to the control module for related module control.

2. The immunoassay analyzer displacement device according to claim 1, characterized in that: The strip-shaped slots (601) and circular slots (602) are arranged in a one-to-one correspondence and are evenly distributed in a ring shape. A discard tube (603) for cooperating with the circular slots (602) to recover the reaction cup (7) is fixedly connected to the reaction disk housing (1).

3. The immunoassay analyzer displacement device according to claim 2, characterized in that: The feeding mechanism (5) comprises a ramp (501), the ramp (501) being detachably connected to the side of the device base (3), the ramp (501) and the device base (3) both being provided with a slide rail (502) for the reaction cup (7) to slide, the cross section of the slide rail (502) being T-shaped and the two slide rails (502) being interconnected.

4. The immunoassay analyzer displacement device according to claim 3, characterized in that: The reaction disk housing (1) is provided with a feed port for cooperating with the slide rail (502) to guide the reaction cup (7) into the strip-shaped slot (601), and the slide rail (502) provided on the ramp platform (501) is in a slope shape.

5. The immunoassay analyzer displacement device according to claim 4, characterized in that: The adjustment and evaluation system comprises: A speed detection unit, used for detecting the movement speed of the push-pull electromagnet (405), which is a speed sensor; A displacement detection unit, used for detecting the displacement distance of a movable iron core column in the push-pull electromagnet (405), which is a distance sensor; A storage module, used to store the data detected by the speed detection unit and the displacement detection unit and to establish a data set; A threshold module, used to retrieve the movement speed information of the push-pull electromagnet (405) at the current moment and the displacement distance information of the movable iron core column in the push-pull electromagnet (405) at the current moment from the storage module, compare the two with a preset threshold, and judge whether at least one of the speed information and the displacement information exceeds the corresponding preset threshold; if at least one of them exceeds the corresponding preset threshold, then judgement information for controlling the stepping motor (401) or the push-pull electromagnet (405) is formed; A control module, used for receiving the judgment information and controlling the stepping motor (401) and the push-pull electromagnet (405) according to the judgment information; The warning module performs warning processing according to the judgment information received by the control module.

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