Sample analyzer

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses a sample analyzer. The sample analyzer comprises a sample distribution device, a reagent distribution device, an ultrasonic device, a determination device and a control device, the ultrasonic device is used for performing ultrasonic uniform mixing on target liquid, and the target liquid is one of a sample, a reagent and mixed liquid at least containing the sample and the reagent; the control device is configured to control the ultrasonic device to work so as to conduct ultrasonic mixing on the target liquid, and the cavitation state of the target liquid in the ultrasonic mixing process is determined according to the working electrical parameters of the ultrasonic device in the ultrasonic mixing process. According to the invention, on-machine automatic detection and judgment of the cavitation state in the ultrasonic working process of the ultrasonic device are realized.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnostic equipment, and in particular to a sample analyzer. Background Art

[0002] A sample analyzer provided by the related technology is provided with an ultrasonic device for transmitting ultrasonic waves to the target liquid to achieve the purpose of ultrasonic mixing or ultrasonic cleaning. Ultrasonic mixing is mainly used to transmit ultrasonic waves to the target liquid to cause cavitation of the target liquid, and the cavitation effect is used to achieve the purpose of quickly mixing the target liquid. Ultrasonic cleaning is mainly used to transmit ultrasonic waves to the target liquid to cause cavitation of the target liquid, and the cavitation effect is used to achieve the purpose of quickly cleaning the parts to be cleaned. It can be seen that whether the target liquid cavitates will directly affect the ultrasonic working purpose of the ultrasonic device. For example, if cavitation does not occur during the ultrasonic mixing process, it may cause the target liquid to fail to achieve the mixing purpose within the mixing cycle, which will further affect the measurement results of the sample.

[0003] However, the sample analyzers of the related art do not have an integrated solution for determining whether cavitation occurs in the target liquid during the ultrasonic operation. In the application scenarios of non-sample analyzers, the following methods are often used to determine whether cavitation occurs in the target liquid: (1) Manual judgment method, which is to make a judgment based on whether there is cavitation noise associated with cavitation, or to observe whether a large number of bubbles are generated in the liquid. (2) Acoustic signal acquisition judgment method, which is to set up a hydrophone to continuously monitor the fluctuations in the target liquid and perform a spectrum analysis on it. When strong white noise is detected, it is considered that cavitation has occurred in this time period. (3) Image acquisition judgment method, which is to install sensors such as CCD in the target container / target liquid to capture phenomena associated with cavitation in the target liquid, such as bubbles generated by cavitation, the glow generated by the collapse of bubbles, etc., to determine whether cavitation has occurred.

[0004] None of the above methods can be integrated into the sample analyzer for use for the following reasons: (1) The manual judgment method can accurately distinguish between cavitation and non-cavitation in small batches and low background noise conditions, but it cannot be integrated into products, is not suitable for large-scale monitoring, and cannot reproduce records. (2) The method of collecting acoustic signals through hydrophones and other methods to monitor whether cavitation has occurred has the disadvantages of large space requirements, difficulty in miniaturization, easy interference from background noise, expensive supporting sensors, and complex software. (3) The method of monitoring and judging whether cavitation has occurred through image sensors also has the disadvantages of difficulty in miniaturization, high cost, and complex system design. It can be seen from this that the cavitation detection solutions currently available in other fields are not conducive to integration on sample analyzers with small working spaces. If integration is required, additional sensors and detection equipment need to be introduced, which will lead to a significant increase in the size and cost of the sample analyzer. Summary of the invention

[0005] The first object of the present invention is to provide a sample analyzer, which aims to solve the technical problem that in the sample analyzer of the related art, it is impossible to determine whether cavitation occurs in the target liquid during the ultrasonic operation without introducing additional sensors and detection equipment.

[0006] To achieve the above object, the present invention provides a solution: a sample analyzer, comprising:

[0007] A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container;

[0008] A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container;

[0009] An ultrasonic device, the ultrasonic device is used to ultrasonically mix a target liquid, the target liquid being one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent;

[0010] a measuring device for measuring a reaction solution made of at least a mixed solution;

[0011] The control device is configured to: control the operation of the ultrasonic device to ultrasonically mix the target liquid, and determine the cavitation state of the target liquid during the ultrasonic mixing process based on the working electrical parameters of the ultrasonic device during the ultrasonic mixing process.

[0012] As an embodiment, the operating electrical parameters of the ultrasonic device include: at least one of the driving voltage, driving current, driving power, and load impedance of the ultrasonic device.

[0013] As an implementation mode, controlling the ultrasonic device to operate so as to ultrasonically mix the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes:

[0014] The ultrasonic device is controlled to work in a constant current driving mode to ultrasonically mix the target liquid, and the cavitation state of the ultrasonic mixing is determined according to the driving voltage of the ultrasonic device during the ultrasonic mixing process.

[0015] As an implementation mode, determining the cavitation state of the ultrasonic mixing according to the driving voltage of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving voltages of the ultrasonic device within a preset time period during the ultrasonic mixing process, calculating a first average value of the multiple driving voltages, and judging whether the first average value is within a preset voltage range, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or,

[0016] Determining the cavitation state of the ultrasonic mixing according to the driving voltage of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving voltages of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving voltages within a preset voltage range reaches a first preset number, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or,

[0017] Determining the cavitation state of the ultrasonic mixing according to the driving voltage of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving voltages of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving voltages within the preset voltage range reaches a first preset ratio; if so, judging that the cavitation of the target liquid in the ultrasonic mixing is successful; if not, judging that the cavitation of the target liquid in the ultrasonic mixing is unsuccessful.

[0018] As an implementation mode, controlling the ultrasonic device to operate so as to ultrasonically mix the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes:

[0019] The ultrasonic device is controlled to work in a constant pressure driving mode to ultrasonically mix the target liquid, and the cavitation state of the ultrasonic mixing is determined according to the driving current of the ultrasonic device during the ultrasonic mixing process.

[0020] As an implementation mode, determining the cavitation state of the ultrasonic mixing according to the driving current of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving currents of the ultrasonic device within a preset time period during the ultrasonic mixing process, calculating a second average value of the multiple driving currents, and judging whether the second average value is within a preset current range, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or,

[0021] Determining the cavitation state of the ultrasonic mixing according to the driving current of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving currents of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving currents within the preset current range reaches a second preset number, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or,

[0022] Determining the cavitation state of the ultrasonic mixing according to the driving current of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving currents of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving currents within the preset current range reaches a second preset ratio; if so, judging that the cavitation of the target liquid in the ultrasonic mixing is successful; if not, judging that the cavitation of the target liquid in the ultrasonic mixing is unsuccessful.

[0023] As an implementation mode, the controlling the ultrasonic device to perform ultrasonic mixing on the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant current driving mode, calculating the load impedance of the ultrasonic device according to the driving voltage of the ultrasonic device during the ultrasonic mixing process, and determining the cavitation state of the ultrasonic mixing according to the load impedance of the ultrasonic device; or,

[0024] The controlling of the ultrasonic device to perform ultrasonic mixing on the target liquid and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant voltage driving mode, calculating the load impedance of the ultrasonic device according to the driving current of the ultrasonic device during the ultrasonic mixing process, and determining the cavitation state of the ultrasonic mixing according to the load impedance of the ultrasonic device.

[0025] As an implementation mode, the ultrasonic device is controlled to operate so as to ultrasonically mix the target liquid, and the cavitation state of the ultrasonic mixing is determined according to the operating electrical parameters of the ultrasonic device during the ultrasonic mixing process, including: the ultrasonic device is controlled to operate in a constant current driving mode or a constant voltage driving mode so as to ultrasonically mix the target liquid, and the cavitation state of the ultrasonic mixing is determined according to the driving power of the ultrasonic device during the ultrasonic mixing process.

[0026] As an embodiment, the controlling the ultrasonic device to operate so as to ultrasonically mix the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: controlling the ultrasonic device to operate in a constant power driving mode so as to ultrasonically mix the target liquid, and determining the cavitation state of the ultrasonic mixing according to the driving voltage and / or driving current of the ultrasonic device during the ultrasonic mixing process; or,

[0027] The controlling the ultrasonic device to perform ultrasonic mixing on the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant power driving mode, calculating the load impedance of the ultrasonic device according to the driving voltage and / or driving current of the ultrasonic device during the ultrasonic mixing process, and determining the cavitation state of the ultrasonic mixing according to the load impedance of the ultrasonic device.

[0028] As an embodiment, the ultrasonic device includes an ultrasonic transducer and an ultrasonic vibrator, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to perform ultrasonic mixing on the target liquid under the drive of the ultrasonic transducer;

[0029] Wherein, the ultrasonic vibrator is an ultrasonic vibrating rod used to be at least partially inserted into the target liquid for ultrasonic mixing; or, the ultrasonic vibrator is a component for ultrasonically mixing the target liquid in a non-contact manner.

[0030] As an embodiment, determining the cavitation state of the target liquid during the ultrasonic mixing process includes: judging whether the cavitation of the target liquid during the ultrasonic mixing is successful or failed, and / or determining the time when the cavitation of the target liquid occurs during the ultrasonic mixing.

[0031] As an embodiment, the control device is further configured to: if it is determined that the cavitation of the target liquid in the ultrasonic mixing fails, then determine that the ultrasonic mixing of the target liquid is invalid, cancel the determination of the target liquid, and re-measure the sample determination item corresponding to the target liquid; or,

[0032] The control device is further configured to: if it is determined that cavitation of the target liquid in this ultrasonic mixing fails, continue to perform the measurement of the target liquid, and add a mark to the measurement result corresponding to the target liquid.

[0033] As an embodiment, the control device is further configured to: if it is determined that cavitation of the target liquid during ultrasonic mixing fails, record a log of cavitation failure.

[0034] As an embodiment, the control device is further configured to: for at least two different sample measurement items and / or at least two different working modes of the sample analyzer, when determining that the target liquid fails to cavitate during ultrasonic mixing, take different treatment measures respectively, and the different treatment measures include at least two of the treatment measures:

[0035] The first processing measure includes: cancelling the determination of the target liquid, retesting the sample determination item corresponding to the target liquid, or cancelling the determination of the target liquid, retesting the sample determination item corresponding to the target liquid, and recording a log of cavitation failure;

[0036] The second processing measure includes: continuing to perform the measurement of the target liquid, adding a mark to the measurement result corresponding to the target liquid, or, including: continuing to perform the measurement of the target liquid, adding a mark to the measurement result corresponding to the target liquid, and recording a log of cavitation failure;

[0037] The third treatment measure includes: recording a log of cavitation failures;

[0038] The sample analyzer has at least two different working modes including a sample measurement mode and a debugging mode.

[0039] A second object of the present invention is to provide a sample analyzer, the sample analyzer comprising:

[0040] A sample dispensing device, the sample dispensing device comprising a sample needle, the sample needle being used to draw a sample from a sample container and to distribute at least a portion of the drawn sample to a reaction container;

[0041] A reagent dispensing device, the reagent dispensing device comprising a reagent needle, the reagent needle being used to draw a reagent from a reagent container and to dispense at least a portion of the drawn reagent into the reaction container;

[0042] a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container, and the stirring rod;

[0043] An ultrasonic device, the ultrasonic device being used to transmit ultrasound to a target liquid under the drive of the ultrasonic device, the target liquid being one of the sample, the reagent, the cleaning liquid, and a mixed liquid containing at least the sample and the reagent;

[0044] a measuring device for measuring a reaction solution made of at least a mixed solution;

[0045] The control device is configured to: control the operation of the ultrasonic device to transmit ultrasonic waves to the target liquid, and determine the cavitation state of the target liquid during the ultrasonic operation according to the working electrical parameters of the ultrasonic device during the operation of the ultrasonic device.

[0046] As an embodiment, the operating electrical parameters of the ultrasonic device include: at least one of the driving voltage, driving current, driving power, and load impedance of the ultrasonic device.

[0047] As an embodiment, the ultrasonic device includes an ultrasonic transducer and an ultrasonic vibrator, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to transmit ultrasound to the target liquid under the drive of the ultrasonic transducer;

[0048] The ultrasonic vibrator is an ultrasonic vibrating rod used to be at least partially inserted into the target liquid for ultrasonic vibration, or the ultrasonic vibrator is a component that transmits ultrasonic waves to the target liquid in a non-contact manner.

[0049] The sample analyzer provided by the present invention determines the cavitation state of the target liquid in the ultrasonic mixing process according to the working electrical parameters of the ultrasonic device in the ultrasonic mixing process, so that the cavitation state of the ultrasonic device in the ultrasonic mixing process can be automatically detected and determined by the program control using the inherent device of the sample analyzer. Since the operator does not need to introduce other measuring equipment or sensors during the implementation of the cavitation determination, the cavitation determination method has significant advantages in cost, integration space, and integration ease of use. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0051] Figure 1 is a schematic diagram of the composition of a sample analyzer provided by an embodiment of the present invention;

[0052] Figure 2 is a schematic diagram of the structure of a sample analyzer provided by an embodiment of the present invention;

[0053] Figure 3 is a schematic diagram of ultrasonic mixing of a target liquid by an ultrasonic device provided in an embodiment of the present invention;

[0054] Figure 4 is a schematic diagram of an electromechanical equivalent model of an ultrasonic device provided in an embodiment of the present invention;

[0055] Figure 5 It is a schematic diagram of the composition of the control device provided in an embodiment of the present invention.

[0056] Explanation of the accompanying drawings: 10. Sample analyzer; 100. Ultrasonic device; 110. Ultrasonic transducer; 111. Piezoelectric ceramic component; 120. Ultrasonic vibrator; 200. Control device; 210. Ultrasonic control board; 220. Main control board; 300. Sample dispensing device; 400. Reagent dispensing device; 500. Measurement device; 600. Reagent loading device; 700. Incubation device; 800. Transfer device; 900. Reaction container providing device; 101. Sample management device; 102. Sample transport device; 103. Magnetic separation device; 20. Target liquid; 30. Reaction container. DETAILED DESCRIPTION

[0057] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0058] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0059] It should also be noted that when an element is referred to as being "fixed on" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or may be indirectly connected to the other element through an intermediate element.

[0060] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0061] Embodiment 1:

[0062] like Figures 1 to 5 As shown, the sample analyzer 10 provided in the first embodiment of the present invention includes an ultrasonic device 100, and the ultrasonic device 100 is used to ultrasonically mix the target liquid 20, and the target liquid 20 is one of a sample, a reagent, and a mixed liquid containing at least a sample and a reagent. The ultrasonic device 100 achieves the effect of mixing the target liquid 20 by transmitting ultrasonic waves to the target liquid 20. The use of the ultrasonic device 100 to mix the target liquid 20 has the characteristic of high mixing efficiency, which is conducive to improving the sample measurement efficiency of the sample analyzer 10.

[0063] As an embodiment, the sample analyzer 10 further includes a control device 200 , and the control device 200 is configured to control the ultrasonic device 100 to perform an ultrasonic mixing operation on the target liquid 20 during a mixing period of the target liquid 20 .

[0064] As an implementation mode, the control device 200 is further configured to: control the operation of the ultrasonic device 100 to ultrasonically mix the target liquid 20, and determine the cavitation state of the target liquid 20 during the ultrasonic mixing process according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process. In this implementation mode, the cavitation state of the ultrasonic device 100 during the ultrasonic mixing process is automatically detected and determined by the machine through program control by using the inherent device of the sample analyzer 10. Since the operator does not need to introduce other measuring equipment or sensors during the implementation of the cavitation judgment, the cavitation judgment method has significant advantages in cost, integration space, and ease of integration.

[0065] As an embodiment, the working electrical parameters of the ultrasonic device 100 include: at least one of the driving voltage, driving current, driving power, and load impedance of the ultrasonic device 100. Before and after the cavitation of the target liquid 20 occurs, the bubble content will change sharply near the ultrasonic device 100 transmitting ultrasonic waves to the target liquid 20, resulting in changes in the local density and sound velocity characteristics of the target liquid 20, thereby causing the reaction of the target liquid 20 to the ultrasonic device 100 to change, and then causing the load impedance of the ultrasonic device 100 to change, and reflected in the change of current or voltage at the input end of the ultrasonic device 100. Therefore, in a specific application, the cavitation state of the target liquid 20 during the ultrasonic mixing process can be determined by at least one of the driving voltage, driving current, driving power, and load impedance of the ultrasonic device 100. Among them, the driving voltage and electric current can be directly collected, the driving power can be directly collected or calculated by collecting the driving voltage and electric current, and the load impedance can be calculated by collecting the driving voltage and driving current. It can be seen that the parameters such as driving voltage, driving current, driving power, load impedance, etc. are easy to obtain, and it is easy to use these parameters to determine the cavitation state of the target liquid 20 during the ultrasonic mixing process.

[0066] As an implementation mode, the ultrasonic device 100 is controlled to work so as to ultrasonically mix the target liquid 20, and the cavitation state of the ultrasonic mixing is determined according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process, including: the ultrasonic device 100 is controlled to work in a constant current driving mode so as to ultrasonically mix the target liquid 20, and the cavitation state of the ultrasonic mixing is determined according to the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process. The constant current driving mode is to control the driving current of the ultrasonic device 100 within a preset range during the operation of the ultrasonic device 100. Specifically, the control device 200 adopts a constant current control mode, that is, the current sampling module of the control device 200 always monitors the output current of the control device 200 (that is, the driving current of the ultrasonic device 100). When the output current changes due to a load change, the control device 200 adjusts the output voltage amplitude so that the output current is restored and maintained within the set range value. In this embodiment, in the constant current driving mode, the cavitation state of ultrasonic mixing is determined according to the change of the driving voltage. In this way, the cavitation state can be determined without changing the driving mode of the ultrasonic device 100.

[0067] As an embodiment, the above-mentioned determination of the cavitation state of the ultrasonic mixing according to the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process includes: collecting multiple driving voltages of the ultrasonic device 100 in a preset time period during the ultrasonic mixing process, calculating a first average value of the multiple driving voltages, and judging whether the first average value is within a preset voltage range. If yes, it is judged that the cavitation of the target liquid 20 in the ultrasonic mixing is successful; if not, it is judged that the cavitation of the target liquid 20 in the ultrasonic mixing is unsuccessful. The preset voltage range can be determined in advance by the laboratory and pre-stored in the sample analyzer 10. In the case of constant current driving, the ultrasonic device 100 cannot cavitate the target liquid 20 during the mixing cycle due to a too small driving voltage; and the driving voltage is too large for a long time, which is easy to damage the target liquid 20 and affect the determination of the sample; therefore, in a specific application, only when the first average value of the multiple driving voltages of the ultrasonic device 100 in the preset time period during the ultrasonic mixing process is within the preset voltage range, it is judged that the cavitation of the target liquid 20 in the ultrasonic mixing is successful. If the first average value of the multiple driving voltages of the ultrasonic device 100 within the preset time period during the ultrasonic mixing process is outside the preset voltage range, no matter whether the first average value is less than the lower limit of the preset voltage range or greater than the upper limit of the preset voltage range, it is determined that the cavitation of the target liquid 20 in this ultrasonic mixing has failed, so as to ensure that the judgment function of the cavitation state is realized and that the ultrasonic mixing does not affect the measurement result of the sample.

[0068] In the above embodiment, the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be successful or failed by whether the average value of the driving voltage in the preset time period is within the preset voltage range. Of course, in specific applications, it can also be judged by other characterization methods of the driving voltage. For example, as an alternative embodiment, the cavitation state of the ultrasonic mixing is determined according to the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process, including: collecting multiple driving voltages of the ultrasonic device 100 in the preset time period during the ultrasonic mixing process, judging whether the number of multiple driving voltages within the preset voltage range reaches a first preset number, if yes, then the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be successful, if not, then the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be failed. The first preset number can be determined in advance by the laboratory and pre-stored in the sample analyzer 10. In this alternative embodiment, the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be successful or failed by the number of driving voltages within the preset voltage range within the preset time period.

[0069] Alternatively, as another alternative embodiment, the cavitation state of the ultrasonic mixing is determined according to the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process, including: collecting multiple driving voltages of the ultrasonic device 100 within a preset time period during the ultrasonic mixing process, and determining whether the number of multiple driving voltages within the preset voltage range reaches a first preset ratio, if yes, then the cavitation of the target liquid 20 in the ultrasonic mixing is determined to be successful, if not, then the cavitation of the ultrasonic mixing is determined to be unsuccessful. The first preset ratio can be determined in advance by the laboratory and pre-stored in the sample analyzer 10. In this alternative embodiment, the cavitation of the target liquid 20 in the ultrasonic mixing is determined to be successful or unsuccessful by the number of driving voltages within the preset voltage range within the preset time period.

[0070] As an implementation manner, the driving voltage used as the judgment signal includes, but is not limited to: the amplitude of the driving voltage, the peak value of the driving voltage, and the valley value of the driving voltage.

[0071] As an implementation mode, the method for collecting the working electrical parameters or equivalent signals of the ultrasonic transducer 110 of the sample analyzer 10 can be a direct collection method or an indirect collection method, for example: (1) collecting the working electrical parameters as the judgment signal through an external or integrated data acquisition module; (2) collecting the working electrical parameters as the judgment signal through on-board solutions such as comparison circuits; (3) collecting the final output working electrical parameters of the ultrasonic control board 210 as the judgment signal; (4) collecting an intermediate signal of a certain link in the ultrasonic control board 210 as the judgment signal, and the intermediate signal has a fixed relationship with the final output working electrical parameters.

[0072] As an embodiment, the above determination of the cavitation state of the target liquid 20 during the ultrasonic mixing process includes: judging whether the cavitation of the target liquid 20 during the ultrasonic mixing is successful or failed, and determining the time when the cavitation of the target liquid 20 occurs during the ultrasonic mixing. In this embodiment, the working electrical parameters of the ultrasonic device 100 can be used to judge whether the target liquid 20 has cavitation, and when the cavitation of the target liquid 20 has occurred. Of course, in a specific application, as an alternative embodiment, the above determination of the cavitation state of the target liquid 20 during the ultrasonic mixing process can also include only one of the following: judging whether the cavitation of the target liquid 20 during the ultrasonic mixing is successful or failed, and determining the time when the cavitation of the target liquid 20 occurs during the ultrasonic mixing.

[0073] As an implementation method after determining that cavitation fails, the control device 200 is further configured to: if it is determined that cavitation of the target liquid 20 in this ultrasonic mixing fails, the ultrasonic mixing of the target liquid 20 is determined to be invalid, and the determination of the target liquid 20 is canceled, and the sample determination items corresponding to the target liquid 20 are re-measured. In this implementation method, after determining that cavitation fails, the target liquid 20 is directly invalidated and the target liquid 20 is no longer measured.

[0074] As another implementation after determining that cavitation has failed, the control device 200 is further configured to: if it is determined that the cavitation of the target liquid 20 in the ultrasonic mixing has failed, then continue to perform the measurement of the target liquid 20, and add a mark to the measurement result corresponding to the target liquid 20. In this embodiment, after determining that cavitation has failed, the target liquid 20 is not discarded, the target liquid 20 is continued to be measured, and a mark is added to the measurement result. The mark is used to prompt the operator that the cavitation has failed in the ultrasonic mixing operation in the measurement result.

[0075] As another implementation after determining cavitation failure, the control device 200 is further configured to: if it is determined that cavitation of the target liquid 20 during ultrasonic mixing fails, record a log of cavitation failure. In this implementation, by recording a log of cavitation failure, it is convenient for operators to check the cause of cavitation failure later.

[0076] As an embodiment, the control device 200 is also configured to: for at least two different sample measurement items and / or at least two different working modes of the sample analyzer 10, when determining the cavitation failure of the target liquid 20 during ultrasonic mixing, take different treatment measures respectively, and the different treatment measures include at least two of the treatment measures: a first treatment measure, a second treatment measure, and a third treatment measure. Among them, the first treatment measure includes: canceling the measurement of the target liquid 20, re-testing the sample measurement item corresponding to the target liquid 20, or, includes: canceling the measurement of the target liquid 20, re-testing the sample measurement item corresponding to the target liquid 20, and recording a log of cavitation failure. The second treatment measure includes: continuing to perform the measurement of the target liquid 20, adding a mark to the measurement result corresponding to the target liquid 20, or, includes: continuing to perform the measurement of the target liquid 20, adding a mark to the measurement result corresponding to the target liquid 20, and recording a log of cavitation failure. The third treatment measure includes: recording a log of cavitation failure. In specific applications, different treatment measures can be set for different measurement items according to their different requirements for ultrasonic mixing, so as to meet the needs of different measurement items and avoid unnecessary waste of samples and reagents. For example: for measurement items that have relatively high requirements for cavitation success and / or relatively high requirements for ultrasonic mixing effects, the first treatment measure can be adopted; for measurement items that have relatively low requirements for cavitation success and / or relatively low requirements for ultrasonic mixing effects, the second treatment measure can be adopted; for measurement items that have basically no requirements for cavitation success and / or ultrasonic mixing effects, the third treatment measure can be adopted. Of course, in specific applications, as an alternative implementation, the sample analyzer 10 can also only set one or two of the first treatment measure, the second treatment measure, and the third treatment measure.

[0077] As an embodiment, at least two different working modes of the sample analyzer 10 include a sample measurement mode and a debugging mode. The sample measurement mode is a mode for performing sample measurement, and the debugging mode is a mode for debugging the sample analyzer 10. The sample measurement mode can select one of the first processing measure, the second processing measure, and the third processing measure according to different measurement items. The debugging mode can select one of the first processing measure and the third processing measure.

[0078] As an implementation manner, the working mode of the sample analyzer 10 further includes a quality control mode. The quality control mode can select one of the first processing measure, the second processing measure, and the third processing measure according to different quality control items.

[0079] As an embodiment, the ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, the ultrasonic vibrator 120 is connected to the ultrasonic transducer 110, and the ultrasonic vibrator 120 is used to ultrasonically mix the target liquid 20 under the drive of the ultrasonic transducer 110. The control device 200 is electrically connected to the ultrasonic transducer 110 to control the operation of the ultrasonic transducer 110. The ultrasonic transducer 110 is an energy conversion device, which is mainly used to convert the electrical power input by the control device 200 into mechanical power (i.e., ultrasonic waves) and then transmit it out.

[0080] As an implementation mode, the ultrasonic transducer 110 includes a piezoelectric ceramic component 111. The piezoelectric ceramic component 111 is a component made of an electronic ceramic material having piezoelectric and sensitive properties, and can realize mutual conversion between mechanical energy and electrical energy.

[0081] As an embodiment, the ultrasonic vibrator 120 is an ultrasonic vibrator rod for at least partially inserting into the target liquid 20 for ultrasonic mixing. The ultrasonic vibrator 120 transmits ultrasonic waves to the target liquid 20 in a contact manner to achieve ultrasonic mixing of the target liquid 20, which helps to reduce the interference of other external components on the ultrasonic transmission. Of course, in specific applications, the arrangement of the ultrasonic vibrator 120 is not limited to this. For example, as an alternative embodiment, the ultrasonic vibrator 120 is a component for ultrasonically mixing the target liquid 20 in a non-contact manner, and its specific form includes but is not limited to the following situations: an ultrasonic mixing seat for placing a reaction container 30 loaded with the target liquid 20, a vibration rod for transmitting ultrasonic waves to the target liquid 20 from the side of the outside of the reaction container 30 loaded with the target liquid 20, and a vibration rod for inserting into the reaction container 30 loaded with the target liquid 20 but not inserting into the target liquid 20.

[0082] As an embodiment, the ultrasonic vibration rod is a horn. The end surface of the ultrasonic vibration rod away from the ultrasonic transducer 110 is the main output surface of the ultrasonic vibration rod for transmitting ultrasonic waves outward. Before and after cavitation occurs, the bubble content near the end surface of the horn where the ultrasonic device 100 is placed in the target liquid 20 will change dramatically, resulting in changes in the local density and sound velocity characteristics of the target liquid 20, and then causing the reaction of the target liquid 20 to the ultrasonic device 100 to change, that is, the load impedance of the ultrasonic device 100 changes, and is reflected in the driving voltage at the input end of the ultrasonic device 100.

[0083] As an implementation manner, the ultrasonic device 100 further includes a driving mechanism, the ultrasonic transducer 110 and / or the ultrasonic vibrator 120 are connected to the driving mechanism, and the driving mechanism is used to drive the ultrasonic transducer 110 and the ultrasonic vibrator 120 to move.

[0084] As an implementation manner, the driving mechanism is at least used to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position, so that the ultrasonic vibrator 120 ultrasonically mixes the target liquid 20 at the ultrasonic mixing position.

[0085] As an implementation manner, the control device 200 is further configured to: before controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to perform the ultrasonic mixing operation, control the driving mechanism to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position.

[0086] As an implementation mode, the driving mechanism is used to drive the ultrasonic vibrator 120 to move in two-dimensional or three-dimensional space, so that the ultrasonic vibrator 120 moves to different working positions, such as a standby position, an ultrasonic mixing position, a cleaning position, etc.

[0087] As an embodiment, the sample analyzer 10 further includes a sample dispensing device 300, which is used to draw a sample from a sample container and distribute at least part of the drawn sample to a reaction container 30. The sample container is used to load a sample collected from a patient. The reaction container 30 is used to carry the sample for reaction and / or measurement. The sample dispensing device 300 is mainly used to achieve quantitative distribution of the sample.

[0088] As an implementation manner, the sample distributing device 300 is used to draw samples from a sample container located at a sample aspirating position and distribute them to a reaction container 30 located at a sample adding position.

[0089] As an embodiment, the sample dispensing device 300 includes a sample needle, a first motion driving device and a first suction and discharge driving device, wherein the first motion driving device is used to drive the sample needle to move in two-dimensional or three-dimensional space so as to move the sample needle to different positions, such as a standby position, a sample suction position, a sample addition position, a cleaning position, etc. The first suction and discharge driving device is used to drive the sample needle to perform suction and discharge actions.

[0090] As an embodiment, the sample analyzer 10 further includes a reagent dispensing device 400, which is used to absorb reagents from a reagent container and distribute at least part of the absorbed reagents to the reaction container 30. The reagent container is used to store reagents required for the assay. The reagent dispensing device 400 is mainly used to achieve quantitative distribution of reagents.

[0091] As an embodiment, the reagent dispensing device 400 includes a reagent needle, a second motion drive device and a second suction and discharge drive device, and the second motion drive device is used to drive the reagent needle to move in two-dimensional or three-dimensional space, so that the reagent needle moves to different workstations, such as a standby position, a reagent suction position, a reagent addition position, a cleaning position, etc. The second suction and discharge drive device is used to drive the reagent needle to perform suction and discharge actions. It should be noted that the reagent dispensing device 400 may include multiple reagent needles, multiple groups of second motion drive devices and multiple groups of second suction and discharge drive devices, and any two reagent needles can be used to absorb and dispense different types of reagents, respectively, or can be used to absorb and dispense the same type of reagent at different times.

[0092] As an embodiment, the sample analyzer 10 further includes a reagent loading device 600 for storing reagent containers. The reagent dispensing device 400 is used to absorb reagents from the reagent containers on the reagent loading device 600 and distribute at least part of the absorbed reagents into the reaction container 30.

[0093] As an implementation manner, the reagent loading device 600 is in the shape of a disk, and a plurality of reagent positions are formed thereon, and a plurality of reagent containers can be stored simultaneously.

[0094] As an embodiment, the sample analyzer 10 further includes a measuring device 500, which is used to measure the reaction solution made of at least the mixed solution. The measuring device 500 is used to measure the reaction solution in the reaction container 30. The measuring device 500 may be an optical measuring device 500.

[0095] As an embodiment, the sample analyzer 10 further includes an incubation device 700 and a transfer device 800. The incubation device 700 is used to incubate the liquid in the reaction container 30. The transfer device 800 is used to transfer the reaction container 30, for example, to transfer the reaction container 30 after sample addition to the incubation device 700. The reagent dispensing device 400 is used to dispense the reagent into the reaction container 30 located on the incubation device 700. The measuring device 500 is arranged beside the incubation device 700, so as to perform optical measurement on the reaction liquid in the reaction container 30 on the incubation device 700.

[0096] As an embodiment, the incubation device 700 is disc-shaped and has a plurality of incubation holes formed thereon, so that a plurality of reaction containers 30 can be incubated simultaneously.

[0097] As an embodiment, the incubation device 700 is a disc-shaped structure that can drive the reaction container 30 to rotate.

[0098] As an embodiment, the ultrasonic mixing station is located on the incubation device 700. The ultrasonic device 100 is used to ultrasonically mix the target liquid 20 in the reaction container 30 on the incubation device 700. Of course, in a specific application, as an alternative embodiment, the ultrasonic mixing station may not be located on the incubation device 700.

[0099] As an embodiment, the transfer device 800 includes at least one clamping component and at least one third motion driving device for driving the clamping component to move.

[0100] As an embodiment, the sample analyzer 10 also includes a reaction container providing device 900 and a reaction container 30 recovery device, the reaction container providing device 900 is used to provide the reaction container 30, and the reaction container 30 recovery device is used to recover the reaction container 30. The sample analyzer 10 also forms a recovery position, and the reaction container 30 recovery device is located below the recovery position. The transfer device 800 is also used to transfer the reaction container 30 from the incubation device 700 to the recovery position for release and recovery. In this embodiment, the reaction container 30 is a disposable container, that is, a reaction container 30 is recycled after completing a measurement project. Of course, in specific applications, the reaction container 30 can also be a recycled container, that is, the reaction container 30 completes a measurement project, can be cleaned in the sample analyzer 10 and then reused for other measurement projects.

[0101] As an embodiment, the sample analyzer 10 also includes a sample management device 101 and a sample transport device 102. The sample management device 101 is used to place a sample container loaded with a sample to achieve sample loading and storage. The sample transport device 102 is used to transport the sample container output by the sample management device 101 to the sample suction position.

[0102] As an embodiment, the control device 200 includes an ultrasonic control board 210 and a main control board 220. The ultrasonic control board 210 is used to control the operation of the ultrasonic device 100, and the main control board 220 is used to control at least the operation of the ultrasonic control board 210, the sample dispensing device 300, the reagent dispensing device 400, and the measuring device 500. In this embodiment, the ultrasonic control board 210 and the main control board 220 are two independent circuit boards. Of course, in a specific application, as an alternative embodiment, the ultrasonic control board 210 and the main control board 220 can also be integrated into one circuit board.

[0103] As an embodiment, the main control board 220 is also used to control the operation of the incubation device 700 , the transfer device 800 , the magnetic separation device 103 , the reaction container providing device 900 , the sample management device 101 and the sample transport device 102 .

[0104] As an embodiment, the sample is a blood sample, the sample analyzer 10 is an immunoanalyzer, and the sample analyzer 10 also includes a magnetic separation device 103, which is used to magnetically separate the liquid in the reaction container 30. The liquid treated by the magnetic separation device 103 includes a clear liquid and a magnetic bead liquid, the clear liquid is treated as a waste liquid, and the magnetic bead liquid is used to prepare a subsequent reaction liquid. The measurement process of a measurement item in the immunoanalyzer includes: adding a sample, adding a reagent to form a first mixed liquid, mixing and incubating the first mixed liquid to obtain a second mixed liquid, magnetically separating the second mixed liquid to obtain a liquid after magnetic separation, adding a substrate to the liquid after magnetic separation to obtain a third mixed liquid, mixing and incubating the third mixed liquid to obtain a reaction liquid, and optically measuring the reaction liquid. During the magnetic separation process, the operation of adding a separation liquid and mixing will be performed. The above-mentioned mixed liquid as the target liquid 20 includes at least one of the following situations: a first mixed liquid after adding a sample and a reagent and before incubation, a second mixed liquid during the magnetic separation process, and a third mixed liquid formed after the magnetic separation and the addition of a substrate and before incubation. Of course, in a specific application, the type of the sample analyzer 10 is not limited thereto. For example, as an alternative embodiment, the sample analyzer 10 may also be a biochemical analyzer, a blood routine cell analyzer, or a coagulation analyzer.

[0105] This embodiment also provides a control method for the ultrasonic device 100 in the sample analyzer 10, and the control method includes the following steps: controlling the ultrasonic device 100 to perform ultrasonic mixing on the target liquid 20, and determining the cavitation state of the target liquid 20 during the ultrasonic mixing process according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process. In this embodiment, the control method of the ultrasonic device 100 in the sample analyzer 10 is similar to the control principle described in the above sample analyzer 10, and will not be described in detail here.

[0106] This embodiment also provides a computer-readable storage medium, which stores a computer program. When the computer program is executed by a processor (e.g., the processor in the control device 200 described above), the processor implements the steps of the control method of the ultrasonic device 100 in the sample analyzer 10 described above. The computer-readable storage medium may be an internal storage unit of the sample analyzer 10 described above, such as a hard disk or memory of the sample analyzer 10; or, the computer-readable storage medium may also be an external storage device of the sample analyzer 10, such as a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (FlashCard), etc., equipped on the sample analyzer 10.

[0107] As an implementation method, the online judgment principle of the ultrasonic mixing process of the ultrasonic device 100 in the sample analyzer 10 includes the following:

[0108] 1) The electromechanical equivalent model of the ultrasonic device 100 is as follows: Figure 4 As shown, U is the driving voltage (also the working voltage of the ultrasonic device 100) input by the ultrasonic control board 210 to the ultrasonic device 100; C0 is the static capacitance of the ultrasonic device 100; L1 is the dynamic inductance of the ultrasonic device 100 (i.e., the equivalent inductance of the ultrasonic device 100 when it is unloaded); C1 is the dynamic capacitance of the ultrasonic device 100 (i.e., the equivalent capacitance of the ultrasonic device 100 when it is unloaded); R1 is the dynamic resistance of the ultrasonic device 100 (i.e., the equivalent resistance of the ultrasonic device 100 when it is unloaded); Z1 is the dynamic impedance of the ultrasonic device 100 (i.e., the equivalent impedance of the ultrasonic device 100 when it is unloaded); L2 is the equivalent load inductance acting on the ultrasonic device 100; C2 is the equivalent load capacitance acting on the ultrasonic device 100; R2 is the equivalent load resistance acting on the ultrasonic device 100; and Z2 is the equivalent load impedance acting on the ultrasonic device 100. When the frequency of the driving voltage U is the same as the resonant frequency of the dynamic branch determined by L1 and C1, the no-load dynamic branch is purely resistive; at the same time, the impedance of the static branch determined by C0 under the driving voltage U is large enough to make R1≈U / I, where U and I are the amplitudes of the voltage and current at both ends of the ultrasonic device 100, respectively.

[0109] 2) When the ultrasonic device 100 is working, it radiates ultrasonic waves into the target liquid 20. The load it receives depends on the reaction of the target liquid 20 to the ultrasonic device 100, and is related to the characteristics of the target liquid 20 and the boundary conditions of the acoustic field. The boundary conditions of the acoustic field include: the radiation surface of the ultrasonic device 100, the geometric shape and size of the container of the target liquid 20, and their relative positional relationship; in the process of repetitive operation, the change of this part is very small. The characteristics of the target liquid 20 mainly refer to the density and sound velocity of the liquid. The density and sound velocity of the target liquid 20 are strongly related to the bubble content of the target liquid 20. Before and after cavitation occurs, the bubble content changes sharply near the end face of the horn where the ultrasonic device 100 is placed in the medium of the target liquid 20, resulting in changes in the local density and sound velocity characteristics of the target liquid 20, thereby changing the reaction of the target liquid 20 to the ultrasonic device 100, and the load impedance of the ultrasonic device 100 changes accordingly, which is reflected in the driving current and driving voltage at the input end of the ultrasonic device 100. By monitoring the changes in the driving current and driving voltage at the input end of the ultrasonic device 100, the changes in the load impedance of the ultrasonic device 100 can be monitored, and it can be monitored and determined whether cavitation occurs in the target liquid 20 under the action of the ultrasonic device 100, and when cavitation occurs.

[0110] In this embodiment, the ultrasonic device 100 driven by constant current control is taken as an example to introduce a specific implementation scheme: the ultrasonic control board 210 outputs an alternating voltage signal that is consistent with or close to the resonant frequency of the ultrasonic device 100 to the two poles of the piezoelectric ceramic component 111 of the ultrasonic device 100. The ultrasonic control board 210 adopts a constant current control mode, that is, the current sampling module of the ultrasonic control board 210 always monitors the output current of the ultrasonic control board 210 (the driving current input by the ultrasonic device 100). When the output current changes due to load changes, the ultrasonic control board 210 adjusts the output voltage amplitude to restore and maintain the output current within the set range. The voltage sampling module on the ultrasonic control board 210 collects the current output voltage and transmits it to the control device 200. When the target liquid 20 acted by the ultrasonic device 100 undergoes cavitation, causing the load impedance of the ultrasonic device 100 to change, the driving voltage at both ends of the ultrasonic device 100 changes under the drive of constant current control, and is collected and transmitted to the control device 200 by the voltage sampling module. The control device 200 compares the currently collected voltage with a cavitation voltage range threshold value determined in advance by experiments (it can be an average value comparison or a single comparison calculation that satisfies the number and ratio) to determine whether cavitation is currently occurring.

[0111] The cavitation judgment scheme provided in this embodiment has the following advantages compared with cavitation judgment schemes in other fields: (1) Compared with manual monitoring and judgment, the scheme of this embodiment can realize automatic and online monitoring and judgment, and is easy to integrate in the sample analyzer 10, which is particularly suitable for monitoring large-scale ultrasonic work. (2) Compared with the schemes such as hydrophone and CCD image sensor, the technical scheme of this embodiment uses the equivalent impedance of the feedback of the ultrasonic device 100 itself to monitor the cavitation state, without the need to introduce other sensors, and the system design is simpler, more compact and more economical; it can be applied to the automatic monitoring of cavitation state in a small space. (3) Since the equivalent load on the ultrasonic device 100 is related to the state of the target liquid 20 near the ultrasonic radiation surface, it can sense the change of bubble content in a small range, so the scheme of this embodiment has higher sensitivity; and is not affected by environmental factors such as working environment noise and photosensitivity conditions, and has higher stability.

[0112] Embodiment 2:

[0113] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in the driving mode of the ultrasonic device 100 and the cavitation judgment mode. Specifically, in the first embodiment, the ultrasonic device 100 is controlled to work in a constant current driving mode, and the cavitation state of the ultrasonic mixing is determined by the change of the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process; while in the present embodiment, the ultrasonic device 100 is controlled to work in a constant voltage driving mode, and the cavitation state of the ultrasonic mixing is determined by the change of the driving current of the ultrasonic device 100 during the ultrasonic mixing process.

[0114] As an implementation mode, in this embodiment, the ultrasonic device 100 is controlled to work so as to ultrasonically mix the target liquid 20, and the cavitation state of the ultrasonic mixing is determined according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process, including: the ultrasonic device 100 is controlled to work in a constant voltage driving mode so as to ultrasonically mix the target liquid 20, and the cavitation state of the ultrasonic mixing is determined according to the driving current of the ultrasonic device 100 during the ultrasonic mixing process. The constant voltage driving mode means that during the operation of the ultrasonic device 100, the driving voltage of the ultrasonic device 100 is controlled to be within a preset range. Specifically, the control device 200 adopts a constant voltage control mode, that is, the voltage sampling module of the control device 200 always monitors the output voltage of the control device 200 (that is, the driving voltage of the ultrasonic device 100), and when the output voltage changes due to a load change, the control device 200 adjusts the output current amplitude so that the output voltage is restored and maintained within the set range value. In this embodiment, in the constant voltage driving mode, the cavitation state of ultrasonic mixing is determined according to the change of the driving current. In this way, the cavitation state can be determined without changing the driving mode of the ultrasonic device 100.

[0115] As an implementation mode, according to the driving current of the ultrasonic device 100 during the ultrasonic mixing process, the cavitation state of the ultrasonic mixing is determined, including: collecting multiple driving currents of the ultrasonic device 100 in a preset time period during the ultrasonic mixing process, calculating the second average value of the multiple driving currents, and judging whether the second average value is within the preset current range. If yes, it is judged that the cavitation of the target liquid 20 in the ultrasonic mixing is successful; if not, it is judged that the cavitation of the target liquid 20 in the ultrasonic mixing is unsuccessful. The preset current range can be determined in advance by the laboratory and pre-stored in the sample analyzer 10. Under constant voltage driving conditions, if the driving current is too small, the ultrasonic device 100 will not be able to cavitate the target liquid 20 during the mixing cycle; if the driving current is too large for a long time, it is easy to damage the target liquid 20, affecting the determination of the sample. Therefore, if the second average value of multiple driving currents of the ultrasonic device 100 within the preset time period during the ultrasonic mixing process is outside the preset current range, no matter whether the second average value is less than the lower limit of the preset current range or greater than the upper limit of the preset current range, it is determined that the cavitation of the target liquid 20 in this ultrasonic mixing has failed, so as to ensure that the judgment function of the cavitation state is realized and that the ultrasonic mixing will not affect the measurement results of the sample.

[0116] In the above-mentioned embodiment, the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be successful or failed by whether the average value of the driving current in the preset time period is within the preset current range. Of course, in specific applications, it can also be judged by other characterization methods of the driving current. For example, as an alternative embodiment, the cavitation state of the ultrasonic mixing is determined according to the driving current of the ultrasonic device 100 during the ultrasonic mixing process, including: collecting multiple driving currents of the ultrasonic device 100 in the preset time period during the ultrasonic mixing process, judging whether the number of multiple driving currents within the preset current range reaches a second preset number, if yes, then the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be successful, if not, then the cavitation of the ultrasonic mixing is judged to be failed. The second preset number can be determined in advance by the laboratory and pre-stored in the sample analyzer 10. In this alternative embodiment, the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be successful or failed by the number of driving currents within the preset current range within the preset time period.

[0117] Alternatively, as an alternative embodiment, the cavitation state of the ultrasonic mixing is determined according to the driving current of the ultrasonic device 100 during the ultrasonic mixing process, including: collecting multiple driving currents of the ultrasonic device 100 within a preset time period during the ultrasonic mixing process, and determining whether the number of multiple driving currents within the preset current range reaches a second preset ratio, if yes, then the cavitation of the target liquid 20 in the ultrasonic mixing is determined to be successful, if not, then the cavitation of the ultrasonic mixing is determined to be unsuccessful. The second preset ratio can be determined in advance by the laboratory and pre-stored in the sample analyzer 10. In this alternative embodiment, the cavitation of the target liquid 20 in the ultrasonic mixing is determined to be successful or unsuccessful by the number of driving currents within the preset current range within the preset time period.

[0118] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0119] Embodiment three:

[0120] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in that the cavitation judgment method is different, which is specifically reflected in that: in the first embodiment, the cavitation state of the ultrasonic mixing is determined by the change of the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process under the constant current driving mode; while in this embodiment, the cavitation state of the ultrasonic mixing is determined by the change of the load impedance of the ultrasonic device 100 during the ultrasonic mixing process under the constant current driving mode.

[0121] As an implementation mode, in this embodiment, the ultrasonic device 100 is controlled to work so as to ultrasonically mix the target liquid 20, and the cavitation state of this ultrasonic mixing is determined according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process, including: controlling the ultrasonic device 100 to work in a constant current driving mode so as to ultrasonically mix the target liquid 20, calculating the load impedance of the ultrasonic device 100 according to the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process, and determining the cavitation state of this ultrasonic mixing according to the load impedance of the ultrasonic device 100. In this implementation mode, the load impedance is first calculated by the driving voltage and the driving current, and the cavitation state of the ultrasonic mixing is determined according to the change of the load impedance, so that the cavitation state can be judged without changing the driving mode of the ultrasonic device 100.

[0122] As an implementation mode, the cavitation state of the ultrasonic mixing is determined according to the load impedance of the ultrasonic device 100, including: calculating multiple load impedances of the ultrasonic device 100 in a preset time period during the ultrasonic mixing process, calculating a third average value of the multiple load impedances, and judging whether the third average value is within a preset impedance range, if yes, judging that the cavitation of the target liquid 20 in the ultrasonic mixing is successful, and if no, judging that the cavitation of the target liquid 20 in the ultrasonic mixing is unsuccessful. In this implementation mode, judging whether the cavitation of the target liquid 20 in the ultrasonic mixing is successful or unsuccessful is judged by judging whether the average value of the load impedance in the preset time period is within the preset impedance range.

[0123] Of course, in specific applications, it can also be judged by other characterization methods of load impedance. For example, as an alternative implementation, the cavitation state of this ultrasonic mixing is determined according to the load impedance of the ultrasonic device 100, including: calculating multiple load impedances of the ultrasonic device 100 within a preset time period during the ultrasonic mixing process, and judging whether the number of multiple load impedances within the preset impedance range reaches a third preset number, if yes, then the cavitation of this ultrasonic mixing is judged to be successful, if not, then the cavitation of this ultrasonic mixing is judged to be a failure. In this alternative implementation, the cavitation of the target liquid 20 in the ultrasonic mixing is judged to be successful or failed by the number of load impedances within the preset impedance range within the preset time period.

[0124] Alternatively, as another alternative embodiment, the cavitation state of the ultrasonic mixing is determined according to the load impedance of the ultrasonic device 100, including: calculating multiple load impedances of the ultrasonic device 100 within a preset time period during the ultrasonic mixing process, and determining whether the number of multiple load impedances within the preset impedance range reaches a third preset ratio, if yes, then the cavitation of the ultrasonic mixing is determined to be successful, if not, then the cavitation of the ultrasonic mixing is determined to be unsuccessful. In this alternative embodiment, the cavitation of the target liquid 20 in the ultrasonic mixing is determined to be successful or unsuccessful by the number of load impedances within the preset impedance range within the preset time period.

[0125] In this embodiment, the load impedance used as the judgment signal can be the load impedance amplitude or the load impedance phasor. The impedance phasor includes: impedance amplitude, and the phase difference of capacitance or inductance relative to the driving voltage.

[0126] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0127] Embodiment 4:

[0128] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the third embodiment mainly in that the driving mode of the ultrasonic device 100 is different, which is specifically reflected in that: in the third embodiment, the cavitation state of the ultrasonic mixing is determined by the change of the load impedance of the ultrasonic device 100 during the ultrasonic mixing process under the constant current driving mode; while in this embodiment, the cavitation state of the ultrasonic mixing is determined by the change of the load impedance of the ultrasonic device 100 during the ultrasonic mixing process under the constant voltage driving mode.

[0129] As an implementation mode, in this embodiment, the ultrasonic device 100 is controlled to operate to ultrasonically mix the target liquid 20, and the cavitation state of this ultrasonic mixing is determined according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process, including: controlling the ultrasonic device 100 to operate in a constant voltage driving mode to ultrasonically mix the target liquid 20, calculating the load impedance of the ultrasonic device 100 according to the driving current of the ultrasonic device 100 during the ultrasonic mixing process, and determining the cavitation state of this ultrasonic mixing according to the load impedance of the ultrasonic device 100.

[0130] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first and third embodiments, and will not be described in detail here.

[0131] Embodiment five:

[0132] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in the present embodiment are different from those in the first and second embodiments mainly in that the cavitation judgment methods are different, which are specifically embodied in that: in the first embodiment, the ultrasonic device 100 is controlled to work in a constant current driving mode, and the cavitation state of the ultrasonic mixing is determined by the change of the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process; in the second embodiment, the ultrasonic device 100 is controlled to work in a constant voltage driving mode, and the cavitation state of the ultrasonic mixing is determined by the change of the driving current of the ultrasonic device 100 during the ultrasonic mixing process; and in the present embodiment, the ultrasonic device 100 is controlled to work in a constant current driving mode or a constant voltage driving mode, and the cavitation state of the ultrasonic mixing is determined by the change of the driving power of the ultrasonic device 100 during the ultrasonic mixing process.

[0133] As an implementation mode, in this embodiment, the ultrasonic device 100 is controlled to work so as to ultrasonically mix the target liquid 20, and the cavitation state of this ultrasonic mixing is determined according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process, including: the ultrasonic device 100 is controlled to work in a constant current driving mode or a constant voltage driving mode so as to ultrasonically mix the target liquid 20, and the cavitation state of this ultrasonic mixing is determined according to the driving power of the ultrasonic device 100 during the ultrasonic mixing process. In this implementation mode, the driving power is first calculated by the driving voltage and the driving current, and the cavitation state of the ultrasonic mixing is determined according to the change of the driving power, so that the cavitation state can be determined without changing the driving mode of the ultrasonic device 100.

[0134] As an implementation mode, the cavitation state of the ultrasonic mixing is determined according to the driving power of the ultrasonic device 100 during the ultrasonic mixing process, including: obtaining multiple driving powers of the ultrasonic device 100 within a preset time period during the ultrasonic mixing process, calculating a fourth average value of the multiple driving powers, and judging whether the fourth average value is within a preset power range, if so, judging that the cavitation of the target liquid 20 in the ultrasonic mixing is successful, and if not, judging that the cavitation of the target liquid 20 in the ultrasonic mixing is a failure.

[0135] As another embodiment, the cavitation state of the ultrasonic mixing is determined according to the driving power of the ultrasonic device 100 during the ultrasonic mixing process, including: obtaining multiple driving powers of the ultrasonic device 100 within a preset time period during the ultrasonic mixing process, and determining whether the number of the multiple driving powers within the preset power range reaches a fourth preset number, if yes, determining that the cavitation of the ultrasonic mixing is successful, if not, determining that the cavitation of the ultrasonic mixing is a failure.

[0136] As another embodiment, the cavitation state of the ultrasonic mixing is determined according to the driving power of the ultrasonic device 100 during the ultrasonic mixing process, including: obtaining multiple driving powers of the ultrasonic device 100 within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving powers within the preset power range reaches a fourth preset ratio, if yes, judging that the cavitation of the ultrasonic mixing is successful, if not, judging that the cavitation of the ultrasonic mixing is a failure.

[0137] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first to fourth embodiments and will not be described in detail here.

[0138] Embodiment six:

[0139] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in the driving mode of the ultrasonic device 100 and the cavitation judgment mode. Specifically, in the first embodiment, the ultrasonic device 100 is controlled to work in a constant current driving mode, and the cavitation state of the ultrasonic mixing is determined by the change of the driving voltage of the ultrasonic device 100 during the ultrasonic mixing process; while in the present embodiment, the ultrasonic device 100 is controlled to work in a power driving mode, and the cavitation state of the ultrasonic mixing is determined by the change of one of the driving voltage, driving current, and load impedance of the ultrasonic device 100 during the ultrasonic mixing process.

[0140] As an implementation mode of this embodiment, the ultrasonic device 100 is controlled to operate to ultrasonically mix the target liquid 20, and the cavitation state of this ultrasonic mixing is determined according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process, including: controlling the ultrasonic device 100 to operate in a constant power driving mode to ultrasonically mix the target liquid 20, and determining the cavitation state of this ultrasonic mixing according to the driving voltage and / or driving current of the ultrasonic device 100 during the ultrasonic mixing process.

[0141] As another implementation manner of this embodiment, the ultrasonic device 100 is controlled to operate to ultrasonically mix the target liquid 20, and the cavitation state of this ultrasonic mixing is determined according to the working electrical parameters of the ultrasonic device 100 during the ultrasonic mixing process, including: controlling the ultrasonic device 100 to operate in a constant power driving mode to ultrasonically mix the target liquid 20, calculating the load impedance of the ultrasonic device 100 according to the driving voltage and / or driving current of the ultrasonic device 100 during the ultrasonic mixing process, and determining the cavitation state of this ultrasonic mixing according to the load impedance of the ultrasonic device 100.

[0142] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first to fifth embodiments and will not be described in detail here.

[0143] Embodiment seven:

[0144] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in that the setting function of the ultrasonic device 100 is different, which is specifically reflected in that: in the first embodiment, the ultrasonic device 100 is used to ultrasonically mix the target liquid 20; while in this embodiment, the ultrasonic device 100 is used to transmit ultrasonic waves to the target liquid 20 to clean the parts to be cleaned.

[0145] As an implementation mode, the sample analyzer 10 provided in this embodiment includes a sample dispensing device 300, a reagent dispensing device 400, a measuring device 500, a cleaning liquid supply device, an ultrasonic device 100 and a control device 200. The sample dispensing device 300 includes a sample needle, which is used to draw a sample from a sample container and distribute at least part of the drawn sample to a reaction container 30; the reagent dispensing device 400 includes a reagent needle, which is used to draw a reagent from a reagent container and distribute at least part of the drawn reagent to the reaction container 30; the cleaning liquid supply device is used to supply cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container 30 and the stirring rod. The ultrasonic device 100 is used to transmit ultrasonic waves to the target liquid 20, and the target liquid 20 is a cleaning liquid. The measuring device 500 is used to measure the reaction liquid made of at least a mixed liquid. The control device 200 is configured to: control the ultrasonic device 100 to work so as to transmit ultrasonic waves to the target liquid 20, and determine the cavitation state of the target liquid 20 during the ultrasonic working process according to the working electrical parameters of the ultrasonic device 100 during the working process of the ultrasonic device 100. In this embodiment, when the ultrasonic device 100 is used for ultrasonic cleaning, the cavitation state of the cleaning liquid in the ultrasonic cleaning process is determined according to the working electrical parameters of the ultrasonic device 100 in the ultrasonic cleaning process, so that the cavitation state of the ultrasonic device 100 in the ultrasonic cleaning process can be automatically detected and determined by the program control by using the inherent device of the sample analyzer 10. Since the operator does not need to introduce other measuring equipment or sensors during the implementation of the cavitation determination, the cavitation determination method has significant advantages in cost, integration space, and integration ease of use.

[0146] As an implementation manner, the operating electrical parameters of the ultrasonic device 100 include: at least one of a driving voltage, a driving current, a driving power, and a load impedance of the ultrasonic device 100 .

[0147] As an embodiment, the ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, wherein the ultrasonic vibrator 120 is connected to the ultrasonic transducer 110 for transmitting ultrasound to the target liquid 20 under the drive of the ultrasonic transducer 110; wherein the ultrasonic vibrator 120 is an ultrasonic vibration rod for at least partially inserting into the target liquid 20 for ultrasonic vibration, or the ultrasonic vibrator 120 is a component for transmitting ultrasonic waves to the target liquid 20 in a non-contact manner.

[0148] As an embodiment, when the ultrasonic device 100 is used to clean the sample needle, the sample analyzer 10 further includes a first cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the first cleaning tank to clean the sample needle. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is a first ultrasonic seat arranged outside the first cleaning tank, and the first ultrasonic seat is used to transmit ultrasonic waves from outside the first cleaning tank to the cleaning liquid in the first cleaning tank to clean the sample needle inserted into the first cleaning tank.

[0149] As an embodiment, when the ultrasonic device 100 is used to clean the reagent needle, the sample analyzer 10 also includes a second cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the second cleaning tank to clean the reagent needle. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is a second ultrasonic seat arranged outside the second cleaning tank. The second ultrasonic seat is used to transmit ultrasonic waves from outside the second cleaning tank to the cleaning liquid in the second cleaning tank to clean the reagent needle inserted into the second cleaning tank.

[0150] As an embodiment, when the ultrasonic device 100 is used to clean the stirring rod, the stirring rod is used to stir the sample or reagent or the mixture of the sample and the reagent in the reaction container 30. The sample analyzer 10 also includes a third cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the third cleaning tank to clean the stirring rod. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120. The ultrasonic vibrator 120 is a third ultrasonic seat provided outside the third cleaning tank. The third ultrasonic seat is used to transmit ultrasonic waves from outside the third cleaning tank to the cleaning liquid in the third cleaning tank to clean the stirring rod inserted into the third cleaning tank.

[0151] As an embodiment, when the ultrasonic device 100 is used to clean the reaction container 30, the cleaning liquid supply device is used to supply the cleaning liquid to the reaction container 30 to clean the reaction container 30. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, the ultrasonic vibrator 120 is an ultrasonic vibration rod inserted into the reaction container 30 or a fourth ultrasonic seat provided outside the reaction container 30, and the ultrasonic vibrator 120 is used to transmit ultrasonic waves to the cleaning liquid in the reaction container 30 to clean the reaction container 30.

[0152] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first to sixth embodiments and will not be described in detail here.

[0153] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container; An ultrasonic device, the ultrasonic device is used to ultrasonically mix a target liquid, the target liquid being one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent; a measuring device for measuring a reaction solution made of at least a mixed solution; The control device is configured to: control the operation of the ultrasonic device to ultrasonically mix the target liquid, and determine the cavitation state of the target liquid during the ultrasonic mixing process based on the working electrical parameters of the ultrasonic device during the ultrasonic mixing process.

2. The sample analyzer according to claim 1, wherein: The operating electrical parameters of the ultrasonic device include: at least one of the driving voltage, driving current, driving power, and load impedance of the ultrasonic device.

3. The sample analyzer according to claim 2, wherein: The controlling the ultrasonic device to perform ultrasonic mixing on the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: The ultrasonic device is controlled to work in a constant current driving mode to ultrasonically mix the target liquid, and the cavitation state of the ultrasonic mixing is determined according to the driving voltage of the ultrasonic device during the ultrasonic mixing process.

4. The sample analyzer according to claim 3, wherein: Determining the cavitation state of the ultrasonic mixing according to the driving voltage of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving voltages of the ultrasonic device within a preset time period during the ultrasonic mixing process, calculating a first average value of the multiple driving voltages, and judging whether the first average value is within a preset voltage range, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or, Determining the cavitation state of the ultrasonic mixing according to the driving voltage of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving voltages of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving voltages within a preset voltage range reaches a first preset number, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or, Determining the cavitation state of the ultrasonic mixing according to the driving voltage of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving voltages of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving voltages within the preset voltage range reaches a first preset ratio; if so, judging that the cavitation of the target liquid in the ultrasonic mixing is successful; if not, judging that the cavitation of the target liquid in the ultrasonic mixing is unsuccessful.

5. The sample analyzer according to claim 2, wherein: The controlling the ultrasonic device to perform ultrasonic mixing on the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: The ultrasonic device is controlled to work in a constant pressure driving mode to ultrasonically mix the target liquid, and the cavitation state of the ultrasonic mixing is determined according to the driving current of the ultrasonic device during the ultrasonic mixing process.

6. The sample analyzer according to claim 5, characterized in that: Determining the cavitation state of the ultrasonic mixing according to the driving current of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving currents of the ultrasonic device within a preset time period during the ultrasonic mixing process, calculating a second average value of the multiple driving currents, and judging whether the second average value is within a preset current range, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or, Determining the cavitation state of the ultrasonic mixing according to the driving current of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving currents of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving currents within the preset current range reaches a second preset number, if yes, judging that the cavitation of the target liquid in the ultrasonic mixing is successful, if no, judging that the cavitation of the target liquid in the ultrasonic mixing is failed; or, Determining the cavitation state of the ultrasonic mixing according to the driving current of the ultrasonic device during the ultrasonic mixing process includes: collecting multiple driving currents of the ultrasonic device within a preset time period during the ultrasonic mixing process, and judging whether the number of the multiple driving currents within the preset current range reaches a second preset ratio; if so, judging that the cavitation of the target liquid in the ultrasonic mixing is successful; if not, judging that the cavitation of the target liquid in the ultrasonic mixing is unsuccessful.

7. The sample analyzer according to claim 2, wherein: The controlling the ultrasonic device to perform ultrasonic mixing on the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant current driving mode, calculating the load impedance of the ultrasonic device according to the driving voltage of the ultrasonic device during the ultrasonic mixing process, and determining the cavitation state of the ultrasonic mixing according to the load impedance of the ultrasonic device; or, The controlling of the ultrasonic device to perform ultrasonic mixing on the target liquid and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant voltage driving mode, calculating the load impedance of the ultrasonic device according to the driving current of the ultrasonic device during the ultrasonic mixing process, and determining the cavitation state of the ultrasonic mixing according to the load impedance of the ultrasonic device.

8. The sample analyzer according to claim 2, wherein: The controlling of the ultrasonic device to perform ultrasonic mixing on the target liquid and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant current driving mode or a constant voltage driving mode and determining the cavitation state of the ultrasonic mixing according to the driving power of the ultrasonic device during the ultrasonic mixing process.

9. The sample analyzer according to claim 2, wherein: The controlling the ultrasonic device to perform ultrasonic mixing on the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant power driving mode, and determining the cavitation state of the ultrasonic mixing according to the driving voltage and / or driving current of the ultrasonic device during the ultrasonic mixing process; or The controlling the ultrasonic device to perform ultrasonic mixing on the target liquid, and determining the cavitation state of the ultrasonic mixing according to the working electrical parameters of the ultrasonic device during the ultrasonic mixing process, includes: controlling the ultrasonic device to perform ultrasonic mixing on the target liquid in a constant power driving mode, calculating the load impedance of the ultrasonic device according to the driving voltage and / or driving current of the ultrasonic device during the ultrasonic mixing process, and determining the cavitation state of the ultrasonic mixing according to the load impedance of the ultrasonic device.

10. The sample analyzer according to any one of claims 1 to 9, characterized in that: The ultrasonic device comprises an ultrasonic transducer and an ultrasonic vibrator, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to perform ultrasonic mixing on the target liquid under the drive of the ultrasonic transducer; Wherein, the ultrasonic vibrator is an ultrasonic vibrating rod used to be at least partially inserted into the target liquid for ultrasonic mixing; or, the ultrasonic vibrator is a component for ultrasonically mixing the target liquid in a non-contact manner.

11. The sample analyzer according to claim 1, wherein: Determining the cavitation state of the target liquid during the ultrasonic mixing process includes: judging whether the cavitation of the target liquid during the ultrasonic mixing is successful or failed, and / or determining the time when the cavitation of the target liquid occurs during the ultrasonic mixing.

12. The sample analyzer according to claim 11, characterized in that: The control device is further configured to: if it is determined that the cavitation of the target liquid in the ultrasonic mixing fails, determine that the ultrasonic mixing of the target liquid is invalid, cancel the determination of the target liquid, and re-measure the sample determination item corresponding to the target liquid; or, The control device is further configured to: if it is determined that cavitation of the target liquid in this ultrasonic mixing fails, continue to perform the measurement of the target liquid, and add a mark to the measurement result corresponding to the target liquid.

13. The sample analyzer according to claim 11 or 12, characterized in that: The control device is further configured to record a log of cavitation failure if it is determined that cavitation of the target liquid fails during ultrasonic mixing.

14. The sample analyzer according to any one of claims 1 to 9 or 11, characterized in that: The control device is further configured to: for at least two different sample measurement items and / or at least two different working modes of the sample analyzer, when determining that the target liquid fails to cavitate during ultrasonic mixing, take different treatment measures respectively, wherein the different treatment measures include at least two of the treatment measures: The first processing measure includes: cancelling the determination of the target liquid, retesting the sample determination item corresponding to the target liquid, or includes: cancelling the determination of the target liquid, retesting the sample determination item corresponding to the target liquid, and recording a log of cavitation failure; The second processing measure includes: continuing to perform the measurement of the target liquid, adding a mark to the measurement result corresponding to the target liquid, or, including: continuing to perform the measurement of the target liquid, adding a mark to the measurement result corresponding to the target liquid, and recording a log of cavitation failure; The third treatment measure includes: recording a log of cavitation failures; The sample analyzer has at least two different working modes including a sample measurement mode and a debugging mode.

15. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device comprising a sample needle, the sample needle being used to draw a sample from a sample container and to distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device comprising a reagent needle, the reagent needle being used to draw a reagent from a reagent container and to dispense at least a portion of the drawn reagent into the reaction container; a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container, and the stirring rod; An ultrasonic device, the ultrasonic device being used to transmit ultrasound to a target liquid under the drive of the ultrasonic device, the target liquid being one of the sample, the reagent, the cleaning liquid, and a mixed liquid containing at least the sample and the reagent; a measuring device for measuring a reaction solution made of at least a mixed solution; A control device is configured to: control the operation of the ultrasonic device to transmit ultrasonic waves to the target liquid, and determine the cavitation state of the target liquid during the ultrasonic operation according to the working electrical parameters of the ultrasonic device during the operation of the ultrasonic device.

16. The sample analyzer according to claim 15, characterized in that: The operating electrical parameters of the ultrasonic device include: at least one of the driving voltage, driving current, driving power, and load impedance of the ultrasonic device.

17. The sample analyzer according to claim 15 or 16, characterized in that: The ultrasonic device comprises an ultrasonic transducer and an ultrasonic vibrator, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to transmit ultrasound to the target liquid under the drive of the ultrasonic transducer; The ultrasonic vibrator is an ultrasonic vibrator rod which is at least partially inserted into the target liquid to perform ultrasonic vibration, or the ultrasonic vibrator is a component which transmits ultrasonic waves to the target liquid in a non-contact manner.

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