Traditional Chinese medicine composition for treating alopecia areata

Abstract

The invention discloses a traditional Chinese medicine composition for treating alopecia areata and belongs to the field of alopecia areata treatment, and the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials by weight: 4000 g of fresh cacumen biotae, 300 g of codonopsis pilosula, 1000 g of radix polygoni multiflori preparata, 300 g of angelica sinensis, 300 g of herba epimedii, 250 g of campsis grandiflora and 250 g of caulis spatholobi. The traditional Chinese medicine composition for treating alopecia areata, provided by the invention, is used as a special medicine for treating alopecia areata in undergraduate, does not contain any glucocorticoid, is convenient to use, causes no pain in the treatment process, has a remarkable curative effect and is suitable for people of all ages. The traditional Chinese medicine rhizoma drynariae has the effects of tonifying kidney, strengthening bone, continuing injury and relieving pain, and can be externally applied to treat alopecia areata by improving hair follicle nutrition and inhibiting hair follicles from entering a degeneration period. When the traditional Chinese medicine composition is used, the rhizoma drynariae is dipped and externally applied to an affected part, so that the hair growing and fixing effects are enhanced. In addition, the traditional Chinese medicine composition for treating alopecia areata provided by the invention is simple in preparation method and relatively low in cost, and can be suitable for industrial production or production of ointment prepared after effective components of medicines are extracted.

Description

Technical Field

[0001] The invention relates to the technical field of alopecia areata treatment, and in particular to a traditional Chinese medicine composition for treating alopecia areata. Background Art

[0002] Alopecia areata is a common non-scarring hair loss, which is mainly manifested by sudden patchy hair loss with clear boundaries, and no scars or inflammatory reactions in the hair loss area. The cause is unknown, and it is generally believed to be related to psychoneurological factors, endocrine disorders, autoimmune reactions, genetics, etc. It belongs to the category of "oil wind" in traditional Chinese medicine. It is commonly known as "ghost hair loss". As early as the Sui Dynasty, it was recorded in the "Treatise on the Causes and Symptoms of Various Diseases", which believed that this disease occurs after the weak part of the head of the human body is invaded by wind evil. "Yi Zong Jin Jian" further deepened the understanding and believed that this syndrome is caused by the opening of pores, and the evil wind invades in the weak part, resulting in strong wind and dry blood, which cannot nourish the hair and cause hair to grow. Modern doctors believe that this disease is mostly caused by overeating spicy, fatty and sweet food, or depression of emotions, which damages yin and consumes blood, heat in the blood generates wind, wind and heat rise, and hair loses its yin and blood nourishment and falls out suddenly; or falls and injuries, blood stasis blocks the collaterals, blood does not flow smoothly, the clear orifices lose nourishment, and hair falls out; or long-term illness leads to deficiency of qi and blood, liver and kidney deficiency, inability of essence to transform into blood, blood does not nourish hair, skin and muscles lose nourishment, hair has no source of growth, hair roots are empty and hair falls out in pieces. It is a disease of deficiency in the root and excess in the superficial, so the treatment is to cool blood, activate blood circulation and regulate qi as the superficial, and to replenish qi, nourish yin and produce essence as the basic, taking both the superficial and the basic into consideration to consolidate hair growth.

[0003] There are many types of prescriptions for treating alopecia areata on the market, but the effects vary. Summary of the invention

[0004] In order to solve the problem that the drugs for treating alopecia areata in the above-mentioned prior art are not effective and the treatment effects are unstable for different groups of people, the present invention provides a traditional Chinese medicine composition for treating alopecia areata.

[0005] To achieve the above technical scheme, a traditional Chinese medicine composition for treating hair loss and alopecia areata is provided, which is prepared from the following traditional Chinese medicine raw materials in the following weight ratio: 4000g fresh Platycladus orientalis leaves, 300g Codonopsis pilosula, 1000g processed Polygonum multiflorum, 300g Angelica sinensis, 300g Epimedium, 250g Campsis creeper, and 250g Millettia reticulata.

[0006] Furthermore, fresh Platycladus orientalis leaves are soaked in 20000 ml of 75% ethanol for 14 days, the liquid is filtered, and the residue is removed to prepare a 20% fresh Platycladus orientalis leaf soaking liquid.

[0007] Furthermore, the remaining medicine is added into the soaking liquid of fresh Platycladus orientalis leaves, soaked for 7 to 14 days, and the liquid is filtered to remove the residue for later use.

[0008] Furthermore, the method of using the Chinese medicine composition is: dip the Drynaria fortunei in the medicine solution, and rub it on the affected area until the skin turns slightly red; the redness of the skin should fade to normal before the second rubbing, and the method is 1 to 2 times a day.

[0009] Furthermore, the Chinese medicine composition has the effects of cooling blood and activating blood circulation, replenishing deficiency and promoting hair growth, and treating alopecia areata.

[0010] The beneficial effects of the present invention are as follows: the Chinese medicine composition for treating alopecia and alopecia provided by the present invention is a special medicine for treating alopecia and alopecia, does not contain any kind of glucocorticoid, is easy to use, has no pain in the treatment process, has significant curative effect, and is suitable for all ages. The Chinese medicine bone drynaria has the effects of tonifying the kidney and strengthening bones, healing wounds and relieving pain. External application can improve the nutrition of hair follicles and inhibit hair follicles from entering the regression phase to treat alopecia. When using the Chinese medicine composition for treating alopecia and alopecia, the bone drynaria is dipped and applied to the affected area to strengthen the power of hair growth and hair fixation.

[0011] In addition, the preparation method of the Chinese medicine composition for treating hair loss and alopecia areata provided by the present invention is simple and of low cost, and can be adapted to industrial production, or produced by extracting the effective ingredients of the medicine and preparing an ointment for production. DETAILED DESCRIPTION

[0012] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other. The present invention will be described in detail below with reference to and in combination with the embodiments.

[0013] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0014] The invention provides a traditional Chinese medicine composition for treating hair loss and alopecia areata. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in weight proportion: 4000g of fresh Platycladus orientalis leaves, 300g of Codonopsis pilosula, 1000g of processed Polygonum multiflorum, 300g of Angelica sinensis, 300g of Epimedium brevicornum, 250g of Campsis creeper and 250g of Millettia spatholobi.

[0015] As a preferred embodiment, fresh Platycladus orientalis leaves are soaked in 20000 ml of 75% ethanol for 14 days, the liquid is filtered, and the residue is removed to prepare 20% fresh Platycladus orientalis leaf soaking liquid.

[0016] As a preferred method, the remaining medicine is added to the soaking liquid of fresh Platycladus orientalis leaves, soaked for 7 to 14 days, filtered to obtain the liquid and remove the residue for later use.

[0017] As a preferred method, the Chinese medicine composition is used as follows: dip Rhizoma Drynariae in medicinal solution and rub the affected area until the skin turns slightly red; the redness of the skin should fade to normal before the second rubbing, 1 to 2 times a day.

[0018] As a preferred embodiment, the Chinese medicine composition has the effects of cooling blood and activating blood circulation, replenishing deficiency and promoting hair growth, and treating alopecia areata.

[0019] The Chinese medicine composition for treating alopecia and alopecia mainly cools blood and promotes blood circulation, replenishes deficiency and promotes hair growth, and is suitable for alopecia. The fresh Platycladus orientalis leaf in the prescription cools blood and stops bleeding, promotes hair growth and blackens hair, and is used externally to treat blood heat and hair loss, and premature graying of hair. The "Compendium of Materia Medica" records that the fresh Platycladus orientalis leaf juice can be applied externally to blacken and moisten the hair, and the fresh product is more powerful than the dry product in clearing away heat and detoxifying. Processed Polygonum multiflorum nourishes the liver and kidney, replenishes essence and blood, blackens hair, and strengthens muscles and bones. Codonopsis pilosula replenishes the middle and replenishes qi, strengthens the spleen and benefits the lungs. Angelica sinensis replenishes blood and harmonizes blood, nourishes blood and moisturizes dryness. The "Bencao Bencao" believes that Angelica sinensis can treat all winds, all blood, replenish all fatigue, break bad blood, and nourish new blood. Herba Epimedii nourishes the kidney and strengthens yang, dispels wind and dampness. Campsis creeper cools blood and removes blood stasis. Millettia reticulata removes blood stasis, produces new blood, and circulates the meridians.

[0020] The whole prescription contains seven herbs, the first two of which are fresh Platycladus orientalis leaves and processed Polygonum multiflorum for hair growth. Laboratory studies have shown that the petroleum ether extract of Platycladus orientalis leaves has a significant promoting effect on hair growth in mice. The hair growth rate of mice in the early stage of drug administration is better than that of the minoxidil group. The high-dose group of Platycladus orientalis leaves petroleum ether has hair growth on the 5th day, 3 days earlier than the minoxidil group. The two components of isomarinol and pinolactone in the petroleum ether extract of Platycladus orientalis leaves can promote the secretion of cytokine vascular endothelial growth factor, increase the number of hair follicles, and have the potential to promote hair growth. The activation rate of tyrosinase by the ethanol extract of processed Polygonum multiflorum is 99%, which is higher than that of traditional hair-blackening drugs such as Ligustrum lucidum and Eclipta prostrata. The last five herbs, Codonopsis pilosula, Angelica sinensis, Epimedium brevicornum, Campsis creeper, Millettia reticulata, can nourish qi and blood, promote blood circulation and remove blood stasis, dilate blood vessels, resist thrombosis, improve scalp microcirculation, increase the amount of hemoglobin, enhance the body's ability to tolerate hypoxia, and fertilize the soil for hair growth.

[0021] The following is an actual case of using the Chinese medicine composition for treating alopecia and alopecia provided by the present invention:

[0022] Case 1:

[0023] Sun, male, 38 years old.

[0024] First visit: June 13, 2019.

[0025] Chief complaint: Patchy hair loss was found at the back of the head for 2 weeks.

[0026] Current medical history: The patient suddenly found a hair loss in an area of ​​the back of the head 2 weeks ago. He reported that he was in good health, had no hair loss, and had no other obvious discomfort symptoms. Recently, he was busy at work and under great pressure, and sometimes felt irritable, had difficulty falling asleep, and occasionally suffered from insomnia.

[0027] Past medical history: denied any other medical history.

[0028] Allergy history: Denied any history of drug or food allergy.

[0029] At present: The patient has hair loss in an area at the back of his head, normal diet, smooth bowel movements, but sometimes he feels irritable, has difficulty falling asleep, and occasionally suffers from insomnia.

[0030] Special examination: A missing hair spot was found at the back of the head, the scalp was clear and smooth, no hair roots were visible, and no scars remained locally.

[0031] Tongue and pulse: red tongue, thin coating, and fine and stringy pulse.

[0032] TCM diagnosis: oily wind and liver and kidney deficiency syndrome.

[0033] Western medicine diagnosis: alopecia areata.

[0034] Treatment method: Use the Chinese medicine composition for treating alopecia and alopecia provided by the present invention to wipe the affected area of ​​alopecia and alopecia, and supplement with some Chinese medicines for soothing the liver and regulating qi, and nourishing the kidney and blood.

[0035] Second visit: June 27, 2019.

[0036] Chief complaint: The patient reported that new hair seemed to grow in the hair loss area, but no new patchy hair loss was seen. His mood was more stable than before, and he was sleeping better than before, without insomnia. His appetite was good, and his bowel movements were normal.

[0037] Special inspection: The area of ​​hair loss at the back of the head has not expanded, the scalp is smooth, and small, velvety hair is growing.

[0038] Tongue and pulse: red tongue, thin coating, and fine and stringy pulse.

[0039] TCM diagnosis: oily wind and liver and kidney deficiency syndrome.

[0040] Western medicine diagnosis: alopecia areata.

[0041] Treatment method: Use the Chinese medicinal composition for treating alopecia and alopecia provided by the present invention to wipe the affected area of ​​alopecia.

[0042] Third visit: July 11, 2019.

[0043] Chief complaint: The patient reported that he was in a stable mood recently, without any irritability, black hair had grown in the area of ​​hair loss, and no new patchy hair loss was observed. His appetite was good, and his bowel movements were normal.

[0044] Special inspection: The area of ​​hair loss at the back of the head has not expanded, and small, soft black hair is growing, which is relatively sparse.

[0045] Tongue and pulse: red tongue, thin coating, and fine and stringy pulse.

[0046] Diagnosis: Alopecia areata.

[0047] Treatment method: Use the Chinese medicinal composition for treating alopecia and alopecia provided by the present invention to wipe the affected area of ​​alopecia.

[0048] Fourth diagnosis: July 25, 2019.

[0049] Chief complaint: The patient reported that he had been under great work pressure recently, felt upset from time to time, and slept late at night, but his sleep was OK. The black hair growth in the hair loss area increased compared with before, and no new patchy hair loss was found. His appetite was good, and his bowel movements were normal.

[0050] Special examination: Black hair was found growing in the area where hair was missing at the back of the head. The number of black hair increased compared to the front and some of the hair was thinner.

[0051] Tongue and pulse: red tongue, thin coating, and fine and stringy pulse.

[0052] TCM diagnosis: oily wind and liver and kidney deficiency syndrome.

[0053] Western medicine diagnosis: alopecia areata.

[0054] Treatment method: Use the Chinese medicine composition for treating alopecia and alopecia provided by the present invention to wipe the affected area of ​​alopecia and alopecia, and supplement with some Chinese medicines for soothing the liver and regulating qi, and nourishing the kidney and blood.

[0055] Case 1: The patient was busy at work before the onset of the disease, which caused irritability, poor sleep, occasional insomnia, prolonged vision hurts blood and fatigues the liver, prolonged sitting hurts flesh and fatigues the spleen, anger hurts the liver, thinking hurts the spleen, essence and blood are damaged, liver depression and qi stagnation, qi and blood biochemical deficiency, hair loss due to lack of nourishment and falling off. The Chinese medicine composition for treating alopecia and alopecia provided by the present invention can cool blood and promote blood circulation, replenish deficiency and promote hair growth, and nourish hair follicles to promote new hair growth.

[0056] Case 2:

[0057] Zhu, female, 12 years old.

[0058] First visit: May 20, 2020.

[0059] Chief complaint: Hair loss for 3 years.

[0060] Current medical history: The patient has been suffering from recurrent hair loss for 3 years. The hair grows here and falls out somewhere else, or falls out again in the same place. The hair is mostly on the temples. Laboratory examinations at other hospitals showed no obvious abnormalities. The patient has a good appetite, normal bowel movements, sleeps late at night, and occasionally has insomnia.

[0061] Past medical history: denied any other medical history.

[0062] Allergy history: Denied any history of drug or food allergy.

[0063] At present: The patient has patchy hair loss on both temples, normal diet, smooth bowel movements, sleeps late at night, and occasionally suffers from insomnia.

[0064] Special examination: There is patchy hair loss at the temples on both sides, the scalp is smooth, and a small amount of fine hair and white hair grow.

[0065] Tongue and pulse: red tongue, thin white fur, floating pulse.

[0066] TCM diagnosis: oily wind and liver and kidney deficiency syndrome.

[0067] Western medicine diagnosis: alopecia areata.

[0068] Treatment method: Use the Chinese medicine composition for treating hair loss and alopecia areata provided by the present invention to wipe the affected area of ​​alopecia areata, and supplement with a small amount of Chinese medicine for soothing the liver and regulating qi, and nourishing the kidney and blood.

[0069] Second visit: June 5, 2020.

[0070] Main complaint: After using the Chinese medicine composition for treating alopecia and alopecia provided by the present invention to wipe the affected area for 2 weeks and taking a small amount of Chinese medicine for soothing the liver and regulating qi, tonifying the kidney and nourishing blood, the patient's hair fell out and grew back, with most of the hair loss on the forehead and temples. The patient fell asleep earlier than before, and did not suffer from insomnia. The appetite was good, and the bowel movements were normal.

[0071] Special inspection: The hair on both sides of the temples and forehead is sparse, fine and soft, with some white hair growing.

[0072] Tongue and pulse: red tongue, thin white fur, floating pulse.

[0073] TCM diagnosis: oily wind and liver and kidney deficiency syndrome.

[0074] Western medicine diagnosis: alopecia areata.

[0075] Treatment method: Use the Chinese medicinal composition for treating alopecia and alopecia provided by the present invention to wipe the affected area of ​​alopecia.

[0076] Case 2: The patient is young, "the internal organs are delicate, the shape and qi are not full", "the young yang is not full, the young yin is not grown", the lung, spleen and kidney are often insufficient, the schoolwork is heavy, sleeps late at night, consumes essence and blood, and the repair is insufficient. Blood deficiency and blood heat generate wind, wind and wood shake, hair falls off repeatedly, blood does not nourish the spirit, and insomnia occurs from time to time. The Chinese medicine composition for treating hair loss and alopecia areata provided by the present invention can cool blood and activate blood circulation, replenish deficiency and promote hair growth, nourish hair follicles, and promote new hair growth.

[0077] In order to further verify the reliability of the Chinese medicine composition for treating alopecia areata provided by the present invention, I have integrated the clinical data of different topical alopecia areata drugs:

[0078] Table 1 Clinical data of topical drugs for the treatment of alopecia areata

[0079] Group Number of cases get well Significant effect efficient invalid Treatment Group 31 17 9 3 2 Control group 1 32 13 8 8 3 Control group 2 25 5 9 7 4 Control group 3 30 0 2 4 24

[0080] Treatment group: using the Chinese medicine composition for treating alopecia and alopecia provided by the present invention, applying it to the affected area;

[0081] Control group 1: Tinctures of Ligustrum lucidum, Astragalus, Salvia miltiorrhiza, and Ilex holly were made and applied to the affected area;

[0082] Control group 2: 5% minoxidil was applied to the affected area;

[0083] Control group 3: ginger wine soaked in ginger was applied to the affected area;

[0084] Apply externally daily and observe the therapeutic effect after 8 weeks of treatment.

[0085] From the control results, it can be seen that the use of the Chinese medicine composition for treating alopecia and alopecia provided by the present invention can significantly improve the cure rate. Compared with the external tincture described in the control group 1, the cure rate of the Chinese medicine composition for treating alopecia and alopecia provided by the present invention is increased by 14%, the number of people with significant treatment effects is slightly increased, and the inefficiency rate is slightly decreased.

[0086] Compared with control group 2 and control group 3, the Chinese medicine composition for treating alopecia and alopecia areata provided by the present invention greatly improves the cure rate and the significant therapeutic effect rate.

[0087] It can be seen from the comparison data that the traditional Chinese medicine composition for treating hair loss and alopecia areata provided by the present invention has a significant therapeutic effect on alopecia areata and can be directly applied in actual medical treatment.

[0088] In addition, the preparation method of the Chinese medicine composition for treating hair loss and alopecia areata provided by the present invention is simple and of low cost, and can be adapted to industrial production, or produced by extracting the effective ingredients of the medicine and preparing an ointment for production.

[0089] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating alopecia areata, characterized in that: The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in the following weight ratio: 4000g of fresh Platycladus orientalis leaves, 300g of Codonopsis pilosula, 1000g of processed Polygonum multiflorum, 300g of Angelica sinensis, 300g of Epimedium brevicornum, 250g of Campsis creeper and 250g of Millettia spatholobi.

2. The Chinese medicine composition for treating alopecia areata according to claim 1, characterized in that: Fresh Platycladus orientalis leaves were soaked in 20000 ml of 75% ethanol for 14 days, the liquid was filtered, and the residue was removed to prepare 20% fresh Platycladus orientalis leaf soaking liquid.

3. The Chinese medicine composition for treating alopecia areata according to claim 2, characterized in that: Add the remaining medicine to the soaking liquid of fresh Platycladus orientalis leaves, soak for 7 to 14 days, filter the liquid and remove the residue for later use.

4. The Chinese medicine composition for treating alopecia areata according to claim 3, characterized in that: The method of using the Chinese medicine composition is as follows: dip the drynaria rhizome in the medicinal solution and rub the affected area until the skin turns slightly red; the redness of the skin should fade to normal before the second rubbing, and the method is 1 to 2 times a day.

5. The Chinese medicine composition for treating alopecia areata according to claim 4, characterized in that: The traditional Chinese medicine composition has the effects of cooling blood, activating blood circulation, replenishing deficiency and promoting hair growth, and treating alopecia areata.