Vascular repair device and method of vascular repair

Abstract

The present application provides a blood vessel repairing device and a blood vessel repairing method. The blood vessel repairing device comprises a gas inlet pipe and a balloon. The balloon comprises a first surface and a second surface, which jointly define an inner cavity. The first surface is configured to allow gas to pass through and block liquid. The second surface is configured to allow liquid to pass through and block gas. The gas inlet pipe is arranged on one side of the first surface along the length direction of the blood vessel. The second surface on one side along the width direction of the blood vessel is adapted to face the blood vessel. The blood vessel repairing device of the present application can mix gas and liquid, and then directly act on the target site with the product having therapeutic effect, so that the treatment is more efficient, and the adverse effects caused by oral administration of drugs are avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of blood vessel repair, in particular to a blood vessel repair device and a blood vessel repair method. BACKGROUND

[0002] Endothelial injury is an important pathological process of coronary heart disease. On the one hand, the aggregation of lipids under the early damaged endothelium leads to the gradual formation of atherosclerotic plaques, and early repair intervention of the vascular endothelium helps to effectively slow down the progression of atherosclerosis; on the other hand, endothelial injury is also one of the direct negative effects after interventional treatment, including guide wire passing, stent implantation, balloon dilation, etc., and timely repair of endothelial injury after intervention helps to effectively reduce the incidence of postoperative adverse events. Studies have found that endothelial cell injury is a reversible change that can be repaired in many ways, such as through exercise, taking angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), beta blockers, etc.

[0003] In related technologies, oral drugs are used to treat vascular endothelial injury, but oral drugs have many disadvantages, such as not directly acting on the target site, having certain systemic side effects, and being highly selective for target patient groups. For example, angiotensin-converting enzyme inhibitors (ACEI) can cause hyperkalemia, renal function damage, etc., and are contraindicated in patients with severe renal function damage or hyperkalemia; beta blockers can mask the symptoms of hypoglycemia-related alertness, so they are used with caution in diabetic patients; in addition, beta blockers can also cause increased airway resistance, so they are contraindicated in patients with asthma or bronchospastic chronic obstructive pulmonary disease. Therefore, the development of a highly targeted vascular endothelial injury repair tool will effectively reduce the toxic side effects of drugs and achieve more efficient injury repair treatment. SUMMARY

[0004] The main purpose of the present application is to provide a blood vessel repair device and a blood vessel repair method, which can make the treatment more efficient and avoid the adverse effects of oral drugs.

[0005] To achieve the above-mentioned purpose, the embodiments of the present application adopt the following technical solutions:

[0006] The blood vessel repair device comprises a gas inlet pipe and a balloon.

[0007] The balloon comprises a first surface and a second surface, and the first surface and the second surface jointly define an inner cavity. The first surface is configured to allow gas to pass through and to block liquid. The second surface is configured to allow liquid to pass through and to block gas.

[0008] The air inlet pipe is arranged on one side of the first surface along the length direction of the blood vessel, and the second surface on one side along the width direction of the blood vessel is adapted to face the blood vessel.

[0009] In some embodiments, the air inlet pipe comprises an inner pipe and an outer pipe, the outer pipe is sleeved on the outer side of the inner pipe, the inner pipe defines a first guide wire cavity, and the inner pipe and the outer pipe define a gas guide cavity therebetween, the gas guide cavity is adapted to pass in gas, and the blood vessel repair device further comprises a guide wire pipe, the guide wire pipe is connected to two sides of the balloon along the length direction respectively, the guide wire pipe defines a second guide wire cavity, and the first guide wire cavity and the second guide wire cavity are coaxially arranged and are both adapted to pass in a guide wire for interventional therapy.

[0010] In some embodiments, the outer surface of the inner pipe is provided with a first annular electrode extending around, the inner surface of the outer pipe is provided with a second annular electrode extending around, and the first annular electrode and the second annular electrode are configured to be able to ionize the gas in the gas guide cavity and form a plasma after being electrified.

[0011] In some embodiments, the blood vessel repair device further comprises an air outlet pipe, the first surface is distributed on both sides of the balloon along the length direction of the blood vessel, and the air inlet pipe is arranged on the first surface on one side and the air outlet pipe is arranged on the first surface on the other side.

[0012] In some embodiments, the air outlet pipe comprises a first pipe and a second pipe, the maximum outflow area of the first pipe is S1, the maximum outflow area of the second pipe is S2, and the maximum outflow area of the air inlet pipe is S3, and S1+S2≥S3 is satisfied.

[0013] In some embodiments, the air inlet pipe comprises an inner pipe and an outer pipe, the outer pipe is sleeved on the outer side of the inner pipe, the inner pipe defines a first guide wire cavity, and the inner pipe and the outer pipe define a gas guide cavity therebetween, the gas guide cavity is adapted to pass in gas, and the blood vessel repair device further comprises a guide wire pipe, the guide wire pipe is connected to two sides of the balloon along the length direction respectively, the guide wire pipe defines a second guide wire cavity, and the first guide wire cavity and the second guide wire cavity are coaxially arranged and are both adapted to pass in a guide wire for interventional therapy.

[0014] The air outlet pipe comprises a first pipe and a second pipe, and the first pipe and the second pipe are connected to two sides of the balloon respectively along the direction perpendicular to the length direction, and the second guide wire cavity is located between the first pipe and the second pipe.

[0015] In some embodiments, the balloon is oval-shaped when viewed along the length direction of the blood vessel.

[0016] In some embodiments, the balloon comprises a grid net arranged in the inner cavity, and the grid net faces the air inlet pipe along the length direction of the blood vessel.

[0017] The embodiments of the second aspect of the present application also provide a blood vessel repair method, which applies the blood vessel repair device of any of the above embodiments, and the blood vessel repair method comprises:

[0018] passing the gas into the gas inlet tube;

[0019] ionizing the gas to form a plasma;

[0020] mixing the plasma inside the inner cavity with the normal saline to form a plasma-activated liquid;

[0021] passing the plasma-activated liquid through the second surface along the width direction of the blood vessel and to the endothelium of the blood vessel.

[0022] In some embodiments, the gas is nitrogen, so that the plasma is a nitrogen plasma.

[0023] Compared with the prior art, the present application has the following beneficial effects:

[0024] The blood vessel repair device of the present application comprises a gas inlet tube and a balloon. The first surface and the second surface of the balloon jointly define an inner cavity, and the first surface has the property of being permeable to gas but impermeable to liquid, and the second surface has the property of being partially permeable to liquid but impermeable to gas. The gas inlet tube is arranged on one side of the first surface along the length direction of the blood vessel, and one side of the second surface along the width direction of the blood vessel is adapted to face the blood vessel, so that the gas can be introduced into the balloon from the gas inlet tube, and the liquid in the balloon cannot pass through the first surface into the gas inlet tube, and the liquid in the balloon can be mixed with the gas and then transported to the endothelium of the blood vessel through the second surface. Compared with the related art of treating endothelial injury of the blood vessel by oral administration of drugs, the blood vessel repair device of the present application can mix the gas with the liquid, and then directly act on the target site with the product having therapeutic effect, so that the treatment is more efficient, and the adverse effects caused by oral administration of drugs are avoided. BRIEF DESCRIPTION OF DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings in the following description only show some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative labor on the basis of the drawings shown.

[0026] Figure 1 The first side view of the blood vessel repair device provided in the first embodiment of the present application;

[0027] Figure 2 The second side view of the blood vessel repair device provided in the first embodiment of the present application;

[0028] Figure 3 Figure 3 is a third side view of the vascular repair device provided in the first embodiment of the present application;

[0029] Figure 4 Figure 4 is a first side view of the vascular repair device and the blood vessel provided in the second embodiment of the present application;

[0030] Figure 5 Figure 5 is a second side view of the vascular repair device provided in the second embodiment of the present application;

[0031] Figure 6 Figure 6 is a schematic view of the direction of the flow of the substance provided in the vascular repair device provided in the second embodiment of the present application;

[0032] Figure 7 Figure 7 is a flow chart of the method for repairing the blood vessel provided in the second embodiment of the present application.

[0033] BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 is a schematic view of the vascular repair device 100 provided in the first embodiment of the present application;

[0035] Figure 2 is a schematic view of the vascular repair device 100 provided in the second embodiment of the present application;

[0036] Figure 3 is a third side view of the vascular repair device provided in the first embodiment of the present application;

[0037] Figure 4 is a first side view of the vascular repair device and the blood vessel provided in the second embodiment of the present application;

[0038] Figure 5 is a second side view of the vascular repair device provided in the second embodiment of the present application;

[0039] Figure 6 is a schematic view of the direction of the flow of the substance provided in the vascular repair device provided in the second embodiment of the present application;

[0040] Figure 7 is a flow chart of the method for repairing the blood vessel provided in the second embodiment of the present application.

[0041] Figure 8 is a schematic view of the length direction X of the blood vessel 200 provided in the second embodiment of the present application;

[0042] Figure 9 is a schematic view of the width direction Y of the blood vessel 200 provided in the second embodiment of the present application.

[0043] The purposes, functional characteristics and advantages of the present application will be further described with reference to the embodiments and the accompanying drawings. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present application will be apparently and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without any creative work fall within the scope of protection of the present application.

[0045] It should be noted that if the embodiments of the present application involve directionality indication (such as up, down, left, right, front, back, etc.), the directionality indication is only used to explain the relative position relationship, motion condition, etc. between components in a certain posture, and if the certain posture changes, the directionality indication also changes accordingly.

[0046] In addition, if the embodiments of the present application involve descriptions such as "first", "second", etc., the descriptions of "first", "second", etc. are only for description purposes and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of indicated technical features. Therefore, the features limited by "first", "second" can explicitly or implicitly include at least one of the features. In addition, "and / or", "and / or" or "and / or" appearing throughout the text means that the three parallel schemes include A scheme, or B scheme, or A and B are satisfied at the same time. In addition, the technical solutions of each embodiment can be combined with each other, but it must be based on the realization of ordinary skilled in the art, when the combination of technical solutions appears contradictory or unachievable, it should be considered that the combination of technical solutions does not exist and is not within the scope of protection claimed by the present application.

[0047] In the related art, oral drugs are used to treat vascular endothelial damage, but oral drugs have many disadvantages, such as not directly acting on the target site, having certain systemic side effects, and being highly selective for target patients. For example, angiotensin converting enzyme inhibitors (ACEI) can cause hyperkalemia, renal function damage, etc., and are contraindicated in severe renal function damage or hyperkalemia; beta blockers can mask the symptoms of hypoglycemia-related alertness, so they are used with caution in diabetic patients; in addition, beta blockers can also cause increased airway resistance, so they are contraindicated in patients with asthma or bronchospastic chronic obstructive pulmonary disease. Therefore, the development of a highly targeted vascular endothelial damage repair tool will effectively reduce the toxic side effects of drugs and achieve more efficient damage repair treatment.

[0048] In view of this, referring to Figures 1-6 The embodiments of the present application provide a vascular repair device 100, which comprises an air inlet pipe 110 and a balloon 120.

[0049] Specifically, referring to Figures 1-3 According to the needs, the air inlet pipe 110 can be of any shape and material, and the air inlet pipe 110 can be a hose for easy threading into the user's sick part.

[0050] Referring to Figures 1-3The balloon 120 includes a first surface 121 and a second surface 122, which together define an inner cavity 123. The first surface 121 is configured to allow gas to pass through and to block liquid, and the second surface 122 is configured to allow liquid to pass through and to block gas. The gas inlet tube 110 is disposed on one side of the first surface 121 along the length direction X of the blood vessel 200, and the second surface 122 is disposed on one side of the second surface 122 along the width direction Y of the blood vessel 200, and is adapted to face the blood vessel 200. It can be understood that the first surface 121 and the second surface 122 are surface structures of the balloon 120, and can be film-like structures. The first surface 121 and the second surface 122 can define the inner cavity 123 of the balloon 120 itself, and in some embodiments, the balloon 120 can be entirely composed of the first surface 121 and the second surface 122; in other embodiments, the balloon 120 can include other surface structures (which can be the same material as the first balloon 120 or different) in addition to the first surface 121 and the second surface 122. Based on this, by specially setting the properties of the first surface 121 and the second surface 122, gas can be introduced into the balloon 120 from the gas inlet tube 110, and the liquid in the balloon 120 (which can be stored in the balloon 120 itself or introduced into the balloon 120 through other structures) cannot pass through the first surface 121 into the gas inlet tube 110, but the liquid in the balloon 120 can be mixed with (including reacting with) the gas and then transported to the vicinity of the endothelium in the blood vessel 200 through the second surface 122. According to the above functional description, the balloon 120 can have any suitable structure shape, which is not limited here.

[0051] Based on the above settings, a specific embodiment is described below, referring to Figures 1-3In some embodiments, the gas inlet tube 110 can deliver the nitrogen plasma in gaseous state from the first surface 121 to the inner cavity 123, the inner cavity 123 is communicated with a liquid delivery tube to deliver the physiological saline to the inner cavity 123, the nitrogen plasma and the physiological saline are mixed to form a plasma-activated liquid, the balloon 120 is squeezed, and the plasma-activated liquid is further delivered from the second surface 122 to the endothelium of the blood vessel 200, so that the nitrogen plasma-activated liquid acts on the endothelium of the blood vessel 200 to produce a therapeutic effect. The plasma-activated liquid refers to a liquid with physical and chemical activity generated by the interaction of plasma and liquid. Plasma is the fourth state of matter, which contains a large number of active particles such as ions, electrons, excited atoms and molecules, and free radicals. When plasma comes into contact with liquid, these active particles will transfer to the liquid, changing the properties of the liquid, thereby forming a plasma-activated liquid. Previous studies have shown that active substances contained in appropriate concentrations of plasma, such as active nitrogen species, can promote the tube formation of human umbilical vein endothelial cells (HUVEC); some studies have also shown that plasma treatment can promote angiogenesis. For ease of description, the following will be described with the vascular repair device 100 applied to the above-mentioned embodiments.

[0052] It should be noted that the vascular repair device 100 and the vascular repair method of the present application can be applied to any treatment means that needs to deliver substances to the endothelium of the blood vessel 200. And the specific form of treatment can be repair of injury, treatment of disease, palliative treatment, etc.

[0053] As can be seen, the blood vessel repair device 100 of the present application comprises the gas inlet tube 110 and the balloon 120. The first surface 121 and the second surface 122 of the balloon 120 jointly define the inner cavity 123, and the first surface 121 has the property of being permeable to gas but not to water, and the second surface 122 has the property of being partially permeable to water and not to gas. The gas inlet tube 110 is arranged on one side of the first surface 121 along the length direction X of the blood vessel 200, and the second surface 122 on the side of the blood vessel 200 along the width direction Y is adapted to face the blood vessel 200, so that the gas can be introduced into the balloon 120 from the gas inlet tube 110, and the liquid in the balloon 120 cannot pass through the first surface 121 into the gas inlet tube 110, and the liquid in the balloon 120 can be mixed with the gas and then transported to the endothelium of the blood vessel 200 through the second surface 122. Compared with the oral drug treatment for the endothelial injury of the blood vessel 200 in the related art, the blood vessel repair device 100 of the present application can mix the gas with the liquid, and then directly act on the target site with the product having the therapeutic effect, so that the treatment is more efficient, and the adverse effects caused by the oral drug are avoided. The treatment based on the blood vessel repair device 100 of the present application takes the overall as a secondary prevention measure, which is helpful to control the risk factors, prevent the disease progression and improve the prognosis. For the patients who have already suffered from coronary heart disease and other atherosclerotic blood vessel 200 diseases, the preventive treatment for the endothelial injury repair can be regularly performed. The endothelial repair treatment in time after the interventional operation is helpful to effectively reduce the occurrence of adverse events such as lamination tear and new lipid accumulation; at the same time, it is helpful to repair the intimal crack at the stent in time, and is helpful to achieve more rapid stent endothelialization and less acute events such as stent thrombosis.

[0054] For the specific arrangement of the gas inlet tube 110, see Figure 4In some embodiments, the air inlet tube 110 comprises an inner tube 111 and an outer tube 112, the outer tube 112 being sleeved outside the inner tube 111. Through the above arrangement, the inner tube 111 can define a first guide wire cavity 113, and the blood vessel repair device 100 further comprises a guide wire tube 150, the guide wire tube 150 being connected to both sides of the balloon 120 along the length direction X respectively, the guide wire tube 150 defining a second guide wire cavity 151, the first guide wire cavity 113 and the second guide wire cavity 151 being coaxially arranged and being adapted to pass through a guide wire for interventional therapy. Among them, the first guide wire cavity 113 is a cavity of the inner tube 111 itself, the first guide wire cavity 113 and the second guide wire cavity 151 can be adapted to pass through a guide wire at the same time, the sizes of the first guide wire cavity 113 and the second guide wire cavity 151 can be adapted to the size of the guide wire commonly used in cardiovascular 200 interventional surgery, and the first guide wire cavity 113 and the second guide wire cavity 151 can enter the target blood vessel 200 site in the OTW (Over the Wire) mode through the radial artery or femoral artery approach. In the interventional therapy of endothelial injury of the blood vessel 200, the guide wire can mainly play a guiding role and a supporting role. The guiding role is that the guide wire can enter from the peripheral blood vessel 200 (such as the radial artery or the femoral artery), follow the natural trend of the blood vessel 200, pass through the complex branches and curves of the blood vessel 200, and open up a path for subsequent various instruments (blood vessel repair device 100 or other auxiliary instruments). The supporting role is that the guide wire can provide a certain supporting force in the blood vessel 200 to prevent the subsequent catheter and other instruments from being folded or twisted when passing through the curved blood vessel 200 section, and the guide wire can also provide stable support for various instruments. The inner tube 111 and the outer tube 112 define a gas guide cavity 114, and the gas guide cavity 114 is adapted to pass through gas. Among them, the gas guide cavity 114 is a cavity formed between the outer surface of the inner tube 111 and the inner surface of the outer tube 112, which can pass through gas, and the gas can be introduced by other structures of the blood vessel repair device 100 or by external devices. Through the arrangement of the inner tube 111 and the outer tube 112, and the arrangement of the first guide wire cavity 113 and the gas guide cavity 114, the structure of the blood vessel repair device 100 can be more simplified, and the practicability is better.

[0055] Based on the above-mentioned embodiments of the inner tube 111 and the outer tube 112, in order to generate plasma required for treatment, referring to Figure 4In some embodiments, the outer surface of the inner tube 111 is provided with a first annular electrode 115, and the inner surface of the outer tube 112 is provided with a second annular electrode 116. Both the first annular electrode 115 and the second annular electrode 116 are annular, i.e. they extend along the circumferential direction X. The first annular electrode 115 and the second annular electrode 116 are configured to ionize the gas in the gas guiding cavity 114 and form plasma when energized. With the above configuration, in use, the gas can be first introduced into the gas guiding cavity 114, and when the gas reaches the position of the first annular electrode 115 and the second annular electrode 116, the nitrogen gas can be ionized into plasma by the energization of the two electrodes. Thereafter, the plasma can enter the inner cavity 123 of the balloon 120 and mix with the normal saline to form the plasma-activated fluid. According to requirements, in other embodiments, other electrodes of any suitable shape can also be provided and can also ionize to form plasma. In still other embodiments, the plasma can be formed by other structures provided externally and directly delivered into the gas guiding tube 110.

[0056] To further process the gas in the balloon 120 (the gas in the balloon 120 described in the present application includes the un-ionized gas and the plasma), see Figure 4 In some embodiments, the vascular repair device 100 further comprises a gas outlet tube 130. To facilitate the gas to pass through the balloon 120 and be discharged by the gas outlet tube 130, along the length direction X of the blood vessel 200, the first surface 121 is distributed on both sides of the balloon 120, and the gas inlet tube 110 is arranged through the first surface 121 on one side, and the gas outlet tube 130 is arranged through the first surface 121 on the other side. With the above configuration, the gas in the inner cavity 123 of the balloon 120 can be discharged, so that the gas in the inner cavity 123 will not be squeezed and kept in a flowing state, thereby the treatment effect can be better. According to requirements, in other embodiments, along the length direction X, the gas outlet tube 130 and the gas inlet tube 110 can communicate with the same side of the balloon 120.

[0057] Further, see Figure 4 , Figure 5 or Figure 6In some embodiments, the outflow tube 130 comprises a first tube 131 and a second tube 132. The first tube 131 and the second tube 132 can have the same shape or different shapes. In some embodiments, the maximum outflow area of the first tube 131 is S1, the maximum outflow area of the second tube 132 is S2, the maximum outflow area of the inflow tube 110 is S3, and S1+S2≥S3. It can be understood that the above-mentioned limitation makes the total outflow area of the outflow tube 130 equal to or greater than the outflow area of the inflow tube 110, and by controlling the size of the inflow / outflow tube 130, the pressure that the balloon 120 membrane can withstand can be controlled to ensure that the gas is not water permeable, and at the same time, if the total size of the outflow tube 130 is too small, it is easy to make the gas in the balloon 120 difficult to be normally discharged, and affect the ionized plasma effect and gas transportation effect at the inflow tube 110. According to the needs, in other embodiments, S1+S2<S3.

[0058] In addition, referring to Figure 4 , Figure 5 or Figure 6 In some embodiments, along the direction perpendicular to the length direction X, the first tube 131 and the second tube 132 are respectively connected to the two sides of the balloon 120, the inflow tube 110 is located between the first tube 131 and the second tube 132, and the guide wire tube 150 is located between the first tube 131 and the second tube 132. The above-mentioned arrangement can on the one hand make the first tube 131 and the second tube 132 form a avoiding space on the opposite side of the guide wire tube 150, thereby facilitating the guide wire or other instruments to pass through the avoiding space; on the other hand, by arranging the inflow tube 110 between the first tube 131 and the second tube 132 (the axis of the inflow tube 110 can also coincide with the axis of the balloon 120), the position of the gas entering the balloon 120 is approximately located near the axis of the balloon 120, that is, the gas is introduced into the balloon 120 from the middle part, so that the gas distribution and gas movement in the balloon 120 are more uniform, and it is beneficial to the mixing of plasma and physiological saline. More specifically, in some embodiments, the first tube 131 and the second tube 132 are symmetrically arranged with the axis of the inflow tube 110 (or the balloon 120) as the center.

[0059] Referring to Figure 4 In some embodiments, as viewed along the length direction X of the blood vessel 200, the balloon 120 is in an elliptical shape. The above-mentioned arrangement makes the two sides of the balloon 120 with longer dimensions adhere to the blood vessel 200 along the direction perpendicular to the length direction X, and the second surface 122 of the above-mentioned embodiment can be arranged on the two sides of the balloon 120 with longer dimensions, and the plasma-activated liquid discharged from this side can more efficiently act on the endothelium of the blood vessel 200; and the two sides with shorter dimensions are kept apart from the inner wall of the blood vessel 200, which is beneficial for the blood to pass through.

[0060] Referring to Figure 4In some embodiments, the balloon 120 comprises a grid 124 arranged in the inner cavity 123, the grid 124 facing the gas inlet tube 110 along the length direction X of the blood vessel 200. The grid 124 can function to disperse the gas and bubbles, and larger bubbles can be broken into nanoscale small bubbles. Thus, the grid 124 can be arranged in the gas inlet tube 110 (downstream of the first ring electrode 115 and the second ring electrode 116), or the grid 124 can be arranged in the balloon 120, specifically on the side of the balloon 120 close to the gas inlet tube 110 along the length direction X.

[0061] Referring to Figure 4 In some embodiments, the blood vessel repair device 100 further comprises a liquid supply tube 140, the liquid supply tube 140 being in communication with the inner cavity 123 of the balloon 120, the liquid supply tube 140 being used as a physiological saline inlet and outlet of the inner cavity 123, and being used for water flushing and pressurization of the balloon 120.

[0062] Referring to Figures 1-7 Embodiments of the second aspect of the present application also provide a blood vessel repair method, the method using the blood vessel repair device 100 of any of the above embodiments, referring to Figure 7 The blood vessel repair method comprises but is not limited to the following steps:

[0063] S101: passing gas into the gas inlet tube 110;

[0064] S102: ionizing the gas to form plasma;

[0065] S103: mixing the plasma in the inner cavity 123 with physiological saline to form plasma-activated liquid;

[0066] S104: passing the plasma-activated liquid along the width direction Y of the blood vessel 200 through the second surface 122 and to the endothelium of the blood vessel 200.

[0067] The above steps are further described as follows. In step S101, the gas can be passed in by other structures of the blood vessel repair device 100, or can be passed in by external devices. In step S102, the way of ionizing the gas to form plasma can refer to the above description of the first ring electrode 115 and the second ring electrode 116. In step S103, the liquid supply tube 140 described in the above embodiments can be used to supply physiological saline to the inner cavity 123.

[0068] In step S104, the plasma-activated liquid in the inner cavity 123 can be squeezed to the endothelium of the blood vessel 200 by pressurizing the balloon 120.

[0069] Previous studies have shown that active species, such as active nitrogen species, contained in plasma of appropriate concentration can promote the tube formation of human umbilical vein endothelial cells (HUVEC); and studies have also shown that plasma treatment can promote angiogenesis. Therefore, in some embodiments, the gas is nitrogen so that the plasma is nitrogen plasma.

[0070] The following describes a specific embodiment of the blood vessel repair method: the balloon 120 is initially in a deflated state, and after the blood vessel repair device 100 is inserted into the blood vessel 200, physiological saline is injected to inflate the balloon 120, so that part of the balloon 120 can be attached to the blood vessel 200, and the other part is spaced from the blood vessel 200 to form a space for blood flow. Nitrogen gas is then introduced into the gas guide cavity 114 between the inner tube 111 and the outer tube 112, and the gas is ionized by discharging the first annular electrode 115 and the second annular electrode 116 to generate gaseous plasma. The gaseous plasma passes through the gas-permeable and water-impermeable first surface 121 and enters the interior of the balloon 120, mixes with the physiological saline in the interior of the balloon 120, diffuses and reacts to form plasma-activated liquid; since the gas enters the balloon 120 through the grid structure, larger bubbles are broken to form nanoscale small bubbles; since the introduced nitrogen gas is not completely ionized to generate plasma, part of the nitrogen gas directly enters the balloon 120 and passes through the grid, thus forming nitrogen nanobubbles. The plasma-activated liquid is made to pass through the water-permeable and gas-impermeable second surface 122 by pressurization, and is delivered into the blood vessel 200.

[0071] Thanks to the improvements of the blood vessel repair device 100 in the above embodiments, the blood vessel repair method of the second aspect of the present application has the same technical effects as the blood vessel repair device 100 in the above embodiments. Here, no further description is given.

[0072] The above is only the preferred embodiments of the present application, and does not limit the patent scope of the present application, and any equivalent structural transformation made according to the application concept, the content of the specification and the drawings, or direct / indirect application in other related technical fields is included in the patent protection scope of the present application.

Claims

1. A vascular repair device, characterized by, The blood vessel repair device comprises: an air inlet tube; a balloon comprising a first surface and a second surface, the first surface and the second surface together defining an inner cavity, the first surface being configured to allow gas to pass through and to block liquid, the second surface being configured to allow liquid to pass through and to block gas; wherein the air inlet tube is arranged on one side of the first surface along the length direction of the blood vessel, and the second surface is adapted to face the blood vessel along one side of the width direction of the blood vessel; the air inlet tube comprises an inner tube and an outer tube, the outer tube being sleeved on the outer side of the inner tube, the inner tube defining a first guide wire cavity, and the inner tube and the outer tube defining a gas guide cavity therebetween, the gas guide cavity being adapted to pass into gas, and the blood vessel repair device further comprises a guide wire tube, the guide wire tube being connected to the balloon on both sides along the length direction respectively, the guide wire tube defining a second guide wire cavity, the first guide wire cavity and the second guide wire cavity being coaxially arranged and being adapted to pass into a guide wire for interventional therapy; the outer surface of the inner tube is provided with a first annular electrode extending around, and the inner surface of the outer tube is provided with a second annular electrode extending around, the first annular electrode and the second annular electrode being configured to ionize the gas in the gas guide cavity and form plasma after being electrified; the blood vessel repair device further comprises an air outlet tube, the first surface being distributed on both sides of the balloon along the length direction of the blood vessel, and the air inlet tube being arranged in the first surface on one side, and the air outlet tube being arranged in the first surface on the other side; gas can be introduced into the balloon by the air inlet tube, and liquid in the balloon cannot pass through the first surface into the air inlet tube, and liquid in the balloon can be mixed with gas and then transported to the vicinity of the endothelium of the blood vessel through the second surface.

2. The blood vessel repair device according to claim 1, wherein the air outlet tube comprises a first tube and a second tube, the maximum outflow area of the first tube is S1, the maximum outflow area of the second tube is S2, the maximum outflow area of the air inlet tube is S3, and S1+S2≥S3 is satisfied.

3. The blood vessel repair device according to claim 1, wherein the air outlet tube comprises a first tube and a second tube, the first tube and the second tube being connected to both sides of the balloon respectively along a direction perpendicular to the length direction, and the guide wire tube being located between the first tube and the second tube.

4. The blood vessel repair device according to claim 1, wherein the balloon is oval when viewed along the length direction of the blood vessel.

5. The blood vessel repair device according to claim 1, wherein the balloon comprises a grid net arranged in the inner cavity, the grid net facing the air inlet tube along the length direction of the blood vessel.

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