A traditional Chinese medicine composition for treating chronic renal failure with poor appetite, and its preparation method and application

Abstract

The present invention provides a traditional Chinese medicine composition for treating chronic renal failure with poor appetite, as well as its preparation method and application, belonging to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 24-36 parts of Atractylodes macrocephala, 16-24 parts of raw Astragalus membranaceus, 12-18 parts of Poria cocos, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of Sophora flavescens, 6-10 parts of Ginseng, 4-6 parts of Licorice and 1-3 parts of Coptis chinensis. The various traditional Chinese medicine raw materials in the traditional Chinese medicine composition cooperate with each other, have good therapeutic effects on the symptoms of poor appetite associated with chronic renal failure, can significantly improve the condition of poor appetite, promote the body's absorption and utilization of nutrients in food, and improve small intestinal motility. The traditional Chinese medicine composition provided by the present invention can improve the symptoms of spleen and stomach deficiency and coldness in patients with chronic renal failure and poor appetite, and has excellent clinical application prospects.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a traditional Chinese medicine composition for treating chronic renal failure with poor appetite, and a preparation method and application thereof. Background Art

[0002] Chronic renal failure (CRF), also known as chronic renal insufficiency, is a condition characterized by renal impairment caused by various chronic kidney diseases (such as primary glomerular disease, diabetic nephropathy, hypertensive renal damage, polycystic kidney disease, and renal damage caused by immune disorders). Its primary manifestations include decreased renal function and metabolic product retention. CRF not only causes significant damage to the patient's kidneys but can also lead to a variety of complications.

[0003] Poor appetite is a common digestive symptom in patients with chronic renal failure. In Traditional Chinese Medicine (TCM), poor appetite is often associated with spleen and stomach dysfunction, poor Qi and blood circulation, and decreased heart and kidney function. Improving the symptoms of poor appetite associated with chronic renal failure can fundamentally improve the patient's overall immune function, thereby effectively treating chronic renal failure. Therefore, developing a traditional Chinese medicine composition that can treat chronic renal failure associated with poor appetite is of great significance. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating chronic renal failure with poor appetite, as well as its preparation method and application, to provide a new traditional Chinese medicine composition for the treatment of chronic renal failure with poor appetite.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating chronic renal failure with poor appetite. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 24-36 parts of Atractylodes macrocephala, 16-24 parts of raw Astragalus membranaceus, 12-18 parts of Poria cocos, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of Sophora flavescens stems, 6-10 parts of ginseng, 4-6 parts of liquorice and 1-3 parts of Coptis chinensis.

[0007] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by mass: 26-34 parts of Atractylodes macrocephala, 18-22 parts of raw Astragalus membranaceus, 13-17 parts of Poria cocos, 13-17 parts of stir-fried chicken gizzard lining, 9-11 parts of Sophora flavescens stems, 7-9 parts of ginseng, 4.5-5.5 parts of licorice and 1.5-2.5 parts of Coptis chinensis.

[0008] Preferably, the fried chicken's gizzard lining is obtained by mixing chicken's gizzard lining with dry river sand and then frying until light yellow.

[0009] The invention provides a preparation method of the traditional Chinese medicine composition, comprising the steps of mixing a prescribed amount of the traditional Chinese medicine composition raw materials with water, decocting the mixture, separating the solid from the liquid, and taking the liquid portion to obtain the traditional Chinese medicine composition.

[0010] Preferably, the mass volume ratio of the raw materials of the traditional Chinese medicine composition when mixed with water is 0.8-1.2 g:16-24 mL.

[0011] Preferably, the decocting temperature is 90-110° C., the decocting time is 40-80 min, and the decocting times are 2-4 times.

[0012] Preferably, the solid-liquid separation method is filtration.

[0013] The present invention provides a use of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared according to the method in preparing a medicine for treating chronic renal failure with poor appetite.

[0014] Preferably, the dosage forms of the drug include oral solution, granules, tablets and pills.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The present invention combines traditional Chinese medicine theory to provide a Chinese medicine composition with the effects of strengthening the spleen and eliminating dampness, regulating qi and stimulating appetite. The Chinese medicinal raw materials in the Chinese medicine composition cooperate with each other to have a good therapeutic effect on the symptoms of poor appetite associated with chronic renal failure, can significantly improve the condition of poor appetite, promote the body's absorption and utilization of nutrients in food, and improve small intestinal motility. The Chinese medicine composition provided by the present invention can improve the symptoms of spleen and stomach deficiency and coldness in patients with chronic renal failure and poor appetite, and has excellent clinical application prospects. DETAILED DESCRIPTION

[0017] The invention provides a traditional Chinese medicine composition for treating chronic renal failure with poor appetite. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 24-36 parts of Atractylodes macrocephala, 16-24 parts of raw Astragalus membranaceus, 12-18 parts of Poria cocos, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of Sophora flavescens stems, 6-10 parts of ginseng, 4-6 parts of liquorice and 1-3 parts of Coptis chinensis.

[0018] Atractylodes macrocephala: bitter, sweet and warm in nature, enters the spleen and stomach meridians; sweet tonic and diuretic, bitter, warm and dry, mainly used to warm and nourish, and can also eliminate dampness; good at replenishing qi and strengthening the spleen, drying dampness and promoting diuresis, stopping sweating, and calming the fetus, treating spleen and stomach qi deficiency, spleen deficiency edema, phlegm and fluid retention, spontaneous sweating due to superficial deficiency and fetal movement disorder.

[0019] Raw Astragalus: sweet and warm in nature, enters the lung and spleen meridians; has the effects of replenishing qi and strengthening the exterior, promoting diuresis and detoxification, draining pus, and healing sores and promoting tissue regeneration; used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, long-term diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to exterior deficiency, edema due to qi deficiency, carbuncles that are difficult to heal, long-term ulcers that do not heal, blood deficiency and jaundice, internal heat and thirst, etc.

[0020] Poria: sweet, light and flat in nature, it enters the heart, lung, spleen and kidney meridians; it has the effects of dispelling dampness and promoting diuresis, strengthening the spleen and eliminating dampness, calming the mind and soothing the nerves; it is used for dysuria, vomiting, diarrhea, palpitations, insomnia and forgetfulness, etc.

[0021] Fried Chicken Gizzard: sweet and neutral in nature, enters the spleen, stomach, small intestine and bladder meridians; has the effects of strengthening the stomach and digestion, astringing sperm and stopping nocturnal emission; mainly used for vomiting, diarrhea, indigestion, infantile malnutrition, enuresis and nocturnal emission.

[0022] Su Geng: Also known as Perilla stem, it is pungent and warm in nature, and enters the lung and spleen meridians; it has the effects of regulating qi, relieving fullness, relieving pain, and calming the fetus; it is used for chest and diaphragm fullness, epigastric pain, belching and vomiting, and fetal movement disorder.

[0023] Ginseng: sweet, slightly bitter, slightly warm, enters the spleen, lung, heart, and kidney meridians; has the effects of replenishing qi and strengthening the body, nourishing the spleen and lungs, replenishing qi and producing body fluid, calming the mind and improving intelligence.

[0024] Licorice: sweet and neutral in nature, it enters the heart, lung, spleen and stomach meridians; it has the functions of replenishing qi and tonifying the middle, removing phlegm and relieving cough, detoxifying, relieving pain and alleviating the properties of medicine.

[0025] Coptis chinensis: bitter and cold in nature, enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians; has the effects of clearing heat and dampness, purging fire and detoxifying; used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, restlessness and insomnia, and palpitations.

[0026] In the present invention, the traditional Chinese medicine composition includes the following raw medicines in parts by mass: 26-34 parts of Atractylodes macrocephala, 18-22 parts of raw Astragalus membranaceus, 13-17 parts of Poria cocos, 13-17 parts of stir-fried chicken gizzard lining, 9-11 parts of Sophora flavescens stems, 7-9 parts of ginseng, 4.5-5.5 parts of licorice and 1.5-2.5 parts of Coptis chinensis.

[0027] In the present invention, the Chinese medicine composition preferably includes the following raw materials in parts by mass: 28-32 parts of Atractylodes macrocephala, 19-21 parts of raw Astragalus membranaceus, 14-16 parts of Poria cocos, 14-16 parts of stir-fried chicken gizzard lining, 9.5-10.5 parts of Sophora flavescens stems, 7.5-8.5 parts of ginseng, 4.7-5.3 parts of licorice and 1.8-2.2 parts of Coptis chinensis.

[0028] In the present invention, the Chinese medicine composition further preferably includes the following raw medicines in parts by mass: 30 parts of Atractylodes macrocephala, 20 parts of raw Astragalus membranaceus, 15 parts of Poria cocos, 15 parts of stir-fried Chicken Gizzard Stone, 10 parts of Sophora flavescens, 8 parts of Ginseng, 5 parts of Licorice and 2 parts of Coptis chinensis.

[0029] In the present invention, the fried chicken's gizzard lining is prepared by mixing chicken's gizzard lining with dry river sand and then frying the mixture until the mixture turns light yellow.

[0030] In the present invention, the mass ratio of the chicken's gizzard lining and dry river sand when mixed is 1:40-60, preferably 1:45-55, and more preferably 1:50.

[0031] In the present invention, when the dry river sand is fried to a temperature of 180-220°C, chicken's gizzard lining is added for frying. Preferably, when the dry river sand is fried to a temperature of 190-210°C, chicken's gizzard lining is added for frying. More preferably, when the dry river sand is fried to a temperature of 200°C, chicken's gizzard lining is added for frying.

[0032] In the present invention, the particle size of the dry river sand is 0.8 to 1.2 mm, preferably 0.9 to 1.1 mm, and more preferably 1 mm.

[0033] The invention provides a preparation method of the traditional Chinese medicine composition, comprising the steps of mixing a prescribed amount of the traditional Chinese medicine composition raw materials with water, decocting the mixture, separating the solid from the liquid, and taking the liquid portion to obtain the traditional Chinese medicine composition.

[0034] In the present invention, the mass volume ratio of the raw materials of the traditional Chinese medicine composition when mixed with water is 0.8-1.2 g:16-24 mL, preferably 0.9-1.1 g:18-22 mL, and more preferably 1 g:20 mL.

[0035] In the present invention, the decoction temperature is 90-110°C, preferably 95-105°C, more preferably 100°C, and the decoction time is 40-80 min, preferably 50-70 min, more preferably 60 min; the decoction is repeated 2-4 times, preferably 3 times.

[0036] In the present invention, the solid-liquid separation method is filtration.

[0037] In the present invention, the obtained liquid portion is also dried.

[0038] The present invention provides a use of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared according to the method in preparing a medicine for treating chronic renal failure with poor appetite.

[0039] In the present invention, the dosage forms of the drug include oral liquid, granules, tablets and pills.

[0040] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0041] Example 1

[0042] A method for preparing a traditional Chinese medicine composition for treating chronic renal failure with poor appetite comprises the following steps:

[0043] (1) 50 parts by mass of dry river sand with a particle size of about 1 mm was frying at 200° C., and then 1 part by mass of chicken's gizzard lining was added and quickly frying until the chicken's gizzard lining turned pale yellow (frying time was about 60 seconds) to obtain fried chicken's gizzard lining;

[0044] (2) By weight, 24 parts of Atractylodes macrocephala, 16 parts of raw Astragalus membranaceus, 12 parts of Poria cocos, 12 parts of stir-fried Chicken Gizzard Stone, 8 parts of Sophora flavescens, 6 parts of Ginseng, 4 parts of Licorice, and 1 part of Coptis chinensis were mixed to obtain a raw material for a Chinese medicine composition;

[0045] (3) The raw material of the Chinese medicine composition obtained in step (2) was mixed with water in a mass volume ratio of 1 g:20 mL, and decocted at a temperature of 90° C. for 60 min. After the decoction was completed, the first decoction liquid was filtered out with gauze, and water was added to the medicinal residue and the decoction was repeated twice. The decoction liquids obtained by the three decoctions were mixed and dried at 80° C. to a water content of 10%, thereby obtaining a Chinese medicine composition.

[0046] Example 2

[0047] A method for preparing a traditional Chinese medicine composition for treating chronic renal failure with poor appetite comprises the following steps:

[0048] (1) 50 parts by mass of dry river sand with a particle size of about 1 mm was frying at 200° C., and then 1 part by mass of chicken's gizzard lining was added and quickly frying until the chicken's gizzard lining turned pale yellow (frying time was about 60 seconds) to obtain fried chicken's gizzard lining;

[0049] (2) By weight, 36 parts of Atractylodes macrocephala, 24 parts of raw Astragalus membranaceus, 18 parts of Poria cocos, 18 parts of stir-fried Chicken Gizzard Stone, 12 parts of Sophora flavescens, 10 parts of Ginseng, 6 parts of Licorice, and 3 parts of Coptis chinensis were mixed to obtain a raw material for a Chinese medicine composition;

[0050] (3) The raw material of the Chinese medicine composition obtained in step (2) was mixed with water in a mass volume ratio of 1 g:20 mL, and decocted at a temperature of 110° C. for 60 min. After the decoction was completed, the first decoction liquid was filtered out with gauze, and water was added to the medicinal residue and the decoction was repeated twice. The decoction liquids obtained by the three decoctions were mixed and dried at 80° C. to a water content of 10%, thereby obtaining a Chinese medicine composition.

[0051] Example 3

[0052] A method for preparing a traditional Chinese medicine composition for treating chronic renal failure with poor appetite comprises the following steps:

[0053] (1) 50 parts by mass of dry river sand with a particle size of about 1 mm was frying at 200° C., and then 1 part by mass of chicken's gizzard lining was added and quickly frying until the chicken's gizzard lining turned pale yellow (frying time was about 60 seconds) to obtain fried chicken's gizzard lining;

[0054] (2) By weight, 30 parts of Atractylodes macrocephala, 20 parts of raw Astragalus membranaceus, 15 parts of Poria cocos, 15 parts of stir-fried Chicken Gizzard Stone, 10 parts of Sophora flavescens, 8 parts of Ginseng, 5 parts of Licorice, and 2 parts of Coptis chinensis were mixed to obtain a raw material for a Chinese medicine composition;

[0055] (3) The raw material of the Chinese medicine composition obtained in step (2) was mixed with water in a mass volume ratio of 1 g:20 mL, and decocted at a temperature of 100° C. for 60 min. After the decoction was completed, the first decoction liquid was filtered out with gauze, and water was added to the medicinal residue and the decoction was repeated twice. The decoction liquids obtained by the three decoctions were mixed and dried at 80° C. to a water content of 10%, thereby obtaining a Chinese medicine composition.

[0056] Comparative Example 1

[0057] The difference between this comparative example and Example 3 is that the raw materials of the Chinese medicine composition used are different. The raw materials of the Chinese medicine composition used in this comparative example are obtained by mixing 30 parts of raw astragalus, 20 parts of Poria, 15 parts of Atractylodes, 10 parts of costus root, 8 parts of ginseng, 5 parts of Citrus aurantium and 3 parts of licorice in parts by mass; the remaining steps are the same as in Example 3.

[0058] Test example

[0059] Experimental animals: 50 SD male rats weighing 180-220 g were selected and randomly divided into 5 groups (model control group, Example 1-3 groups and Comparative Example 1 group), with 10 rats in each group. Modeling was carried out after one week of adaptive feeding.

[0060] Modeling method: Rats in the model control group were gavaged once daily with a 200 mg / kg adenine suspension. Rats in groups 1 to 3 and Comparative Example 1 were gavaged once daily with a 200 mg / kg adenine suspension and, 4 hours after the suspension gavage, received a 0.2 g dose of the Chinese medicinal composition prepared in Examples 1 to 3 and Comparative Example 1. The experiment was conducted for 4 weeks, with free access to water and food.

[0061] The changes in the rats were observed before the start of the experiment, on the 7th, 14th, 21st and 28th days of the experiment, and the average body weight of the rats in each treatment group was calculated. The average body weight of the rats in each treatment group is shown in Table 1.

[0062] Table 1 Average body weight of rats in each treatment group during the experimental period (g)

[0063] Treatment group Before the trial begins Test day 7 Test day 14 Test day 21 Test day 28 Model control group 199.7 214.2 209.5 197.6 190.8 Example 1 group 201.6 223.5 217.4 219.3 226.6 Example 2 group 200.1 222.8 216.7 219.0 224.9 Example 3 group 201.3 225.3 220.1 223.2 230.2 Comparative Example 1 198.8 218.7 211.2 211.5 219.8

[0064] The change during observation rat test is found that the model control group rats begin to appear the phenomena such as mental depression, little food, weight loss, reduced activity, polyuria at about 14d of gavage, indicating that the rat model of chronic renal failure with poor appetite is successfully established. The rats of embodiment 1 to 3 groups and comparative example 1 group also begin to appear the phenomena such as mental depression, little food, weight loss, reduced activity, polyuria at about 14d of gavage, but after one week (i.e., gavage 21d or so), the activity of rats obviously increases, and food intake increases, and polyuria obviously reduces. The data recorded in conjunction with Table 1 can be seen that the Chinese medicine composition prepared by the present invention can significantly improve the situation of rat weight loss caused by chronic renal failure compared to comparative example 1 group, and is conducive to promoting the absorption and utilization of nutrients in food by rats.

[0065] The inventors also tested the 24-hour food and water intake of rats in each treatment group before the start of the experiment (the last day of adaptive feeding) and after the end of the experiment (the first day after the end of the experiment). The specific method was: sufficient food and water were placed in the cage, the rats were placed in the cage for 24 hours, and the food and water consumption was measured, that is, the 24-hour food and water intake of the rats. The measurement results are shown in Table 2.

[0066] Table 2 Measurement results of food intake and water intake of rats in each treatment group before and after the experiment (n=5)

[0067]

[0068]

[0069] As can be seen from Table 2, the food intake and water intake of the rats in the model control group were significantly reduced after the end of the experiment, indicating that the rats in the chronic renal failure model constructed had obvious symptoms of poor appetite; the food intake and water intake of the rats in groups 1 to 3 were significantly increased compared with the model control group and the comparative example 1 group, indicating that the traditional Chinese medicine composition prepared by the present invention has a significant effect of improving and treating the symptoms of poor appetite.

[0070] After the experiment, 5 rats were taken from each treatment group to detect the small intestinal propulsion rate. The specific method was as follows: after fasting the rats for 24 hours but not depriving them of water, they were gavaged with an equal amount of activated carbon. Thirty minutes after gavage, the rats were killed by cervical dislocation. The abdominal cavity was opened and the mesentery was separated. The small intestine was cut and placed on a platform. The small intestine was gently pulled into a straight line. The total length of the small intestine and the length from the pylorus to the front of the activated carbon were measured, and the small intestinal propulsion rate was calculated (small intestinal propulsion rate = length from the pylorus to the front of the activated carbon / total length of the small intestine × 100%). The results are shown in Table 3.

[0071] Table 3 Calculation results of small intestinal propulsion rate of rats in each treatment group (n=5)

[0072] Treatment group Small intestinal propulsion rate (%) Model control group 52.83 Example 1 group 83.54 Example 2 group 81.58 Example 3 group 84.04 Comparative Example 1 73.26

[0073] As can be seen from Table 3, compared with the model control group, Examples 1 to 3 and Comparative Example 1 were able to significantly promote intestinal motility in rats; compared with Comparative Example 1, Examples 1 to 3 were more effective in promoting intestinal motility in rats. This indicates that the traditional Chinese medicine composition prepared by the present invention has the ability to significantly promote intestinal motility in rats with chronic renal failure and poor appetite.

[0074] As can be seen from the above examples, the present invention provides a traditional Chinese medicine composition capable of treating chronic renal failure with poor appetite. The traditional Chinese medicine composition can significantly increase the food intake and water intake of rats with chronic renal failure and poor appetite, as well as the absorption and utilization of nutrients in food, and promote small intestinal peristalsis. It can be seen that the traditional Chinese medicine composition prepared by the present invention has achieved the effect of treating chronic renal failure with poor appetite, and the various traditional Chinese medicine raw materials cooperate with each other to have a certain synergistic effect, which is beneficial to fundamentally improve the body's immune function and has excellent clinical application prospects.

[0075] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating chronic renal failure with poor appetite, characterized in that: The traditional Chinese medicine composition is composed of the following raw medicines in parts by mass: 24-36 parts of Atractylodes macrocephala, 16-24 parts of raw Astragalus membranaceus, 12-18 parts of Poria cocos, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of Sophora flavescens stems, 6-10 parts of ginseng, 4-6 parts of liquorice and 1-3 parts of Coptis chinensis.

2. The Chinese medicine composition according to claim 1, wherein The traditional Chinese medicine composition is composed of the following raw medicines in parts by mass: 26-34 parts of Atractylodes macrocephala, 18-22 parts of raw Astragalus membranaceus, 13-17 parts of Poria cocos, 13-17 parts of stir-fried chicken gizzard lining, 9-11 parts of Sophora flavescens stems, 7-9 parts of ginseng, 4.5-5.5 parts of liquorice and 1.5-2.5 parts of Coptis chinensis.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that The fried chicken's gizzard lining is prepared by mixing chicken's gizzard lining with dry river sand and then frying the mixture until the mixture turns pale yellow.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The Chinese medicine composition raw materials in a prescribed amount are mixed with water, boiled, solid-liquid separated, and the liquid portion is taken to obtain the Chinese medicine composition.

5. The method according to claim 4, wherein The mass volume ratio of the raw materials of the traditional Chinese medicine composition when mixed with water is 0.8-1.2 g:16-24 mL.

6. The method according to claim 4, wherein The temperature during the decoction is 90-110° C., the time is 40-80 min, and the number of decoctions is 2-4 times.

7. The method according to claim 4, wherein The solid-liquid separation method is filtration.

8. Use of the traditional Chinese medicine composition according to any one of claims 1 to 3 or the traditional Chinese medicine composition prepared according to the method according to any one of claims 4 to 7 in the preparation of a medicament for treating chronic renal failure with poor appetite.

9. The use according to claim 8, characterized in that The dosage forms of the drug include oral solution, granules, tablets and pills.

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