Oral dissolving film for pets and preparation method of oral dissolving film

Abstract

The invention discloses a pet oral soluble film and a preparation method thereof. The pet oral soluble film is prepared from the following components in parts by mass: a first film-forming agent, a pH value regulator, a pet flavoring agent, a disintegrating agent and a supplement, the first film-forming agent is lycium barbarum polysaccharide extract. According to the pet oral dissolving film, the pH value of the pet oral dissolving film is adjusted to be matched with the pH value of saliva of a pet (dog and cat) through the pH value adjusting agent, the pet oral dissolving film adhered to the corresponding part of the oral cavity of the pet (dog and cat) can be rapidly disintegrated through the disintegrating agent, and discomfort of the pet (dog and cat) caused by long-time adhesion is avoided; the pet flavoring agent can improve the fond degree of pets (dogs and cats) on the pet mouth soluble film according to the taste characteristics of the pets (dogs and cats). Compared with the prior art, the pet oral soluble film is prepared according to the characteristics of pets (dogs and cats), is popular with the pets (dogs and cats) in the actual use process, and can greatly avoid discomfort of the pets (dogs and cats) in the taking process.

Description

Technical Field

[0001] The invention relates to the field of pet products, and in particular to a pet orodispersible film and a preparation method thereof. Background Art

[0002] There are two types of existing orodispersible film technologies. One is a product specifically for human medicines and nutritional supplements, and the other is the Korean pet orodispersible film, which is a inactivated lactic acid bacteria supplement.

[0003] The existing orodispersible film technology has the basic preparation and molding dosage form suitable for human physiological structure and body characteristics. The existing Korean pet orodispersible film simply imitates the molding and preparation technology of human orodispersible film. Both preparation technologies do not prepare orodispersible films suitable for pets (dogs and cats) based on the characteristics of pets (dogs and cats). Summary of the invention

[0004] Based on this, it is necessary to provide a pet orodispersible film that can solve the above problems.

[0005] In addition, it is also necessary to provide a method for preparing the above pet orally dissolving film.

[0006] A pet orodissolving film, comprising, by weight, 20 to 50 parts of a first film-forming agent, 0.5 to 1.5 parts of a pH adjuster, 3 to 10 parts of a pet flavoring agent, 0.5 to 5 parts of a disintegrant, and 10 to 20 parts of a supplement;

[0007] The first film-forming agent is wolfberry polysaccharide extract.

[0008] In one embodiment, the preparation method of the wolfberry polysaccharide extract is as follows: after the wolfberry is crushed, water, enzyme and vitamin C are added according to the solid-liquid ratio of 0.5g~2g:10mL, followed by mixing and enzymolysis for 0.5h~5h under the conditions of pH 5.5~6.5 and temperature of 50℃~65℃, after the reaction is completed, the liquid phase is separated, and the liquid phase is concentrated at a concentration density of 1.35~1.4 to obtain the wolfberry polysaccharide extract, wherein the enzyme is used in an amount of 0.25wt%~1wt%, the vitamin C is used in an amount of 0.2wt%~1wt%, and the enzyme includes cellulase and papain.

[0009] In one embodiment, in the enzyme, the ratio of the cellulase to the papain is 1-3:1.

[0010] In one embodiment, the pH of the pet orodispersible film is 8 to 10;

[0011] The pH adjuster is selected from at least one of tetrasodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, citric acid and lactic acid.

[0012] In one embodiment, the pet flavoring agent includes simple sugar or syrup, amino acid, vitamin B1 and yeast.

[0013] In one embodiment, the mass ratio of the monosaccharide or syrup, the amino acid, the vitamin B1 and the yeast is 10-20: 1-1.9: 0.2-1: 1-3;

[0014] The monosaccharide is selected from at least one of xylose and ribose, the amino acid is selected from at least one of threonine, lysine, glycine, L-cysteine ​​and methionine, and the yeast is fermented beer yeast powder.

[0015] In one embodiment, the disintegrant is selected from at least one of sodium carboxymethyl starch, cross-linked polyvinyl pyrrolidone and cross-linked sodium carboxymethyl cellulose;

[0016] The supplements include tea polyphenols, theaflavins, mint, catnip, lysozyme, chrysanthemum plant extracts, B vitamins and oral probiotics.

[0017] In one embodiment, the pet orally dissolving film further comprises 20 to 50 parts of a second film-forming agent, wherein the second film-forming agent comprises modified starch, pullulan and maltodextrin.

[0018] A method for preparing the above-mentioned pet orally dissolving film comprises the following steps:

[0019] According to the mass proportions, 3 to 10 parts of pet flavoring agent and 20 to 50 parts of water are heated to 95 to 100° C. and kept warm for 25 to 45 minutes, then cooled to 40 to 55° C., 20 to 50 parts of the first film-forming agent are added, 0.5 to 1.5 parts of a pH regulator, 0.5 to 5 parts of a disintegrant and 10 to 20 parts of a supplement are added after mixing evenly, and after mixing evenly again, film spreading, drying, demoulding, cutting and packaging are performed in sequence to obtain the pet orosoluble film.

[0020] A method for preparing the above-mentioned pet orally dissolving film comprises the following steps:

[0021] According to the weight ratio, 20 to 50 parts of the first film-forming agent and 20 to 50 parts of the second film-forming agent are mixed, heated to 60° C. to 80° C., and stirred evenly to obtain a film-forming mixture;

[0022] According to the weight proportions, 3 to 10 parts of pet flavoring agent and 20 to 50 parts of water are heated to 95 to 100° C. and kept warm for 25 to 45 minutes, then cooled to 40 to 55° C. and added with the film-forming mixture, mixed evenly, 0.5 to 1.5 parts of pH regulator, 0.5 to 5 parts of disintegrant and 10 to 20 parts of supplement are added, mixed evenly again, film spreading, drying, demoulding, cutting and packaging are performed in sequence to obtain the pet orosoluble film.

[0023] The pet orodissolving film of the present invention comprises 20 to 50 parts of a first film-forming agent, 0.5 to 1.5 parts of a pH regulator, 3 to 10 parts of a pet flavoring agent, 0.5 to 5 parts of a disintegrant and 10 to 20 parts of a supplement in parts by mass. The pH regulator adjusts the pH of the pet orodissolving film to match the pH of the saliva of the pet (dog or cat). The disintegrant can make the pet orodissolving film adhered to the corresponding part of the oral cavity of the pet (dog or cat) disintegrate quickly to avoid discomfort to the pet (dog or cat) caused by long-term adhesion. The pet flavoring agent can increase the degree of liking of the pet (dog or cat) for the pet orodissolving film according to the taste characteristics of the pet (dog or cat).

[0024] Compared with the prior art, the pet orodispersible film of the present invention is prepared according to the characteristics of pets (dogs and cats) and is suitable for pets (dogs and cats). It is loved by pets (dogs and cats) during actual use and can greatly avoid discomfort to pets (dogs and cats) during taking the product.

[0025] In addition, in the present invention, the first film-forming agent is a Lycium barbarum polysaccharide extract. The Lycium barbarum polysaccharide extract specially extracted in the present invention has a good film-forming effect and is a natural plant polysaccharide with effective ingredients. Its addition can avoid the addition of traditional film-forming agents, thereby increasing the proportion of effective ingredients in the pet orodispersible film of the present invention. At the same time, the Lycium barbarum polysaccharide extract also has anti-inflammatory, antibacterial and anti-stress effects, and enhances immunity.

[0026] Furthermore, in combination with the specific embodiments, the pet orodispersible film of the present invention also has the advantages of improving pet bad breath, reducing the growth of dental plaque, and cleaning the oral cavity.

[0027] Preferably, in the present invention, the orally dissolving film for pets further comprises 20 to 50 parts of a second film-forming agent, and the second film-forming agent comprises modified starch, pullulan and maltodextrin. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0029] in:

[0030] Figure 1 The present invention is a flow chart of a method for preparing an orodispersible film for pets according to one embodiment. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the various parts in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0033] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0034] The present invention discloses an orodispersible pet film according to one embodiment, which comprises, by weight, 20 to 50 parts of a first film-forming agent, 0.5 to 1.5 parts of a pH regulator, 3 to 10 parts of a pet flavoring agent, 0.5 to 5 parts of a disintegrant and 10 to 20 parts of a supplement.

[0035] Specifically, in the present invention, the first film-forming agent is Lycium barbarum polysaccharide extract.

[0036] The pet orodissolving film of the present invention comprises 20 to 50 parts of a first film-forming agent, 0.5 to 1.5 parts of a pH regulator, 3 to 10 parts of a pet flavoring agent, 0.5 to 5 parts of a disintegrant and 10 to 20 parts of a supplement in parts by mass. The pH regulator adjusts the pH of the pet orodissolving film to match the pH of the saliva of the pet (dog or cat). The disintegrant can make the pet orodissolving film adhered to the corresponding part of the oral cavity of the pet (dog or cat) disintegrate quickly to avoid discomfort to the pet (dog or cat) caused by long-term adhesion. The pet flavoring agent can increase the degree of liking of the pet (dog or cat) for the pet orodissolving film according to the taste characteristics of the pet (dog or cat).

[0037] Compared with the prior art, the pet orodispersible film of the present invention is prepared according to the characteristics of pets (dogs and cats) and is suitable for pets (dogs and cats). It is loved by pets (dogs and cats) during actual use and can greatly avoid discomfort to pets (dogs and cats) during taking the product.

[0038] In addition, in the present invention, the first film-forming agent is a Lycium barbarum polysaccharide extract. The Lycium barbarum polysaccharide extract specially extracted in the present invention has a good film-forming effect and is a natural plant polysaccharide with effective ingredients. Its addition can avoid the addition of traditional film-forming agents, thereby increasing the proportion of effective ingredients in the pet orodispersible film of the present invention. At the same time, the Lycium barbarum polysaccharide extract also has anti-inflammatory, antibacterial and anti-stress effects, and enhances immunity.

[0039] Preferably, in this embodiment, the preparation method of wolfberry polysaccharide extract is as follows: after the wolfberry is crushed, water, enzyme and vitamin C are added according to the solid-liquid ratio of 0.5g~2g:10mL, followed by mixing and enzymolysis for 0.5h~5h under the conditions of pH 5.5~6.5 and temperature of 50℃~65℃, after the reaction is completed, the liquid phase is separated, and the liquid phase is concentrated at a concentration density of 1.35~1.4 to obtain wolfberry polysaccharide extract, wherein the enzyme dosage is 0.25wt%~1wt%, the vitamin C dosage is 0.2wt%~1wt%, and the enzyme includes cellulase and papain.

[0040] By enzymolysis of wolfberry with cellulase and papain, the wolfberry polysaccharide in wolfberry can be released better. The wolfberry polysaccharide has viscosity, and by controlling the content of wolfberry polysaccharide, a good film-forming effect can be achieved. In addition, wolfberry also contains pectin components, and no pectinase is added during enzymolysis, so that the obtained wolfberry polysaccharide extract contains pectin, which has a high film-forming property. The retention of pectin makes the film-forming property better.

[0041] More preferably, in the enzyme, the ratio of cellulase to papain is 1 to 3:1.

[0042] Specifically, the wolfberry can be fresh wolfberry or dried wolfberry.

[0043] When the sugar content of wolfberry is too low, the content of wolfberry polysaccharides is insufficient, and the film-forming property is poor or even impossible to form a film; when the sugar content of wolfberry is too high, the content of wolfberry polysaccharides is too high, resulting in excessive adhesion after film formation and difficulty in demolding.

[0044] Preferably, the wolfberry is fresh wolfberry with a sugar content of 35% to 42% or dried wolfberry made from fresh wolfberry with a sugar content of 35% to 42%.

[0045] Preferably, in this embodiment, the pH of the orally dissolving film for pets is 8-10.

[0046] In the present invention, one hundred dogs and cats were tested and statistically found that the pH of the saliva of dogs and cats was about 8-10. Therefore, the pH of the pet orodispersible film of the present invention was adjusted to 8-10 by a pH adjuster.

[0047] Specifically, in order to increase the compliance of oral feeding and improve the bioavailability of oral mucosal absorption, a scientific and reasonable pH regulator is formulated and selected from at least one of tetrasodium pyrophosphate (sodium pyrophosphate), sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, citric acid and lactic acid.

[0048] The pH adjuster is selected from at least one of tetrasodium pyrophosphate (sodium pyrophosphate), sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, citric acid and lactic acid, which can adjust the pet orodispersible film to a flavor preferred by dogs and cats, and the finished product with a similar oral pH value increases the compliance of dogs and cats.

[0049] Lycium barbarum polysaccharide extract is obtained by enzymatic hydrolysis, which preserves the original nutritional components of wolfberry. The enzymatic components after enzymatic hydrolysis not only increase the bioavailability of wolfberry itself, but also increase the bioavailability of other components.

[0050] In addition, in the production process, a certain heating temperature and stirring can well integrate the synergistic effects of various raw material ingredients, thereby increasing the bioavailability of effective raw materials.

[0051] Preferably, in this embodiment, the pet flavoring agent includes monosaccharide or syrup, amino acid, vitamin B1 and yeast.

[0052] Pet flavor enhancers include monosaccharides or syrups, amino acids, vitamin B1 and yeast. The production process can be used to strengthen the reaction between the raw materials. Monosaccharides or syrups, amino acids, vitamin B1 and yeast undergo Maillard reaction to produce flavors and nutritional factors, thereby preparing various oral nutritional supplements with good palatability and orodispersible films.

[0053] More preferably, in this embodiment, the mass ratio of monosaccharide or syrup, amino acid, vitamin B1 and yeast is 10-20:1-1.9:0.2-1:1-3.

[0054] Specifically, the monosaccharide can be selected from at least one of xylose and ribose, the amino acid can be selected from at least one of threonine, lysine, glycine, L-cysteine ​​and methionine, and the yeast can be fermented beer yeast powder.

[0055] More preferably, in this embodiment, the amino acids include threonine, lysine, glycine, L-cysteine ​​and methionine, and the mass ratio of threonine, lysine, glycine, L-cysteine ​​and methionine is 0.2-0.4: 0.3-0.5: 0.2-0.6: 0.2-0.6: 0.1-0.5.

[0056] Particularly, in the present embodiment, the amino acids include threonine, lysine and methionine, and the mass ratio of threonine, lysine and methionine is 0.2-0.4:0.3-0.5:0.5-1.

[0057] Preferably, in this embodiment, the disintegrant is selected from at least one of sodium carboxymethyl starch, cross-linked polyvinyl pyrrolidone and cross-linked sodium carboxymethyl cellulose.

[0058] In order to better improve the compliance of pets and at the same time play the corresponding functional role of active factors, it is necessary to scientifically formulate the speed and time of oral disintegration.

[0059] The optimal pH value promotes the effective absorption of active factors by the oral mucosa. If the orodissolving film disintegrates too quickly, it is not conducive to the retention of active functional factors in the oral cavity. If it disintegrates too slowly, it will cause dogs and cats to resist and feel annoyed by foreign objects in their mouths. Therefore, the disintegration time is controlled between 30s and 90s according to the functional factors.

[0060] Preferably, in this embodiment, the supplements include tea polyphenols, theaflavins, mint, catnip, lysozyme, Asteraceae plant extracts (chamomile, marigold, chrysanthemum), B vitamins and oral probiotics.

[0061] The pet orodispersible film of this embodiment has the effects of refreshing the oral cavity, reducing the growth of dental plaque, cleaning the oral cavity, etc.

[0062] Tea polyphenols have the effects of preventing caries, strengthening teeth and eliminating bad breath.

[0063] Tea polyphenols can kill lactic acid bacteria and other caries bacteria in the gaps between teeth, and inhibit the activity of glucose polymerase, so that the bacteria cannot take root on the teeth, effectively interrupting the process of caries formation. Protein food remaining in the gaps between teeth becomes a matrix for the proliferation of corrupt bacteria, and tea polyphenols can kill such bacteria.

[0064] In addition, tea polyphenols can stimulate gastrointestinal reactions and accelerate large intestine peristalsis to achieve the effect of treating constipation. Tea polyphenols can improve the body's comprehensive immune ability, inhibit and kill various harmful pathogens that cause diarrhea, and relieve the tension of the stomach and intestines to achieve the effect of anti-inflammatory and antidiarrhea.

[0065] Theaflavins are formed by the condensation of catechins catalyzed by polyphenol oxidase during the fermentation process of black tea. It is a general term for a class of compounds with a benzophenone structure and is the main quality component of black tea.

[0066] Theaflavins have strong physiological activity and have antioxidant, anti-inflammatory, antiviral, cardiovascular disease prevention and treatment and antibacterial effects.

[0067] Mint and catnip have a refreshing taste that can make your breath fresher and last longer, and can also prevent bad breath.

[0068] Erythritol is not utilized by Streptococcus mutans in the human mouth and also has an inhibitory effect on oral pathogenic bacteria. Therefore, it can protect teeth and has anti-caries properties.

[0069] Not only will the small molecule erythritol not be used and decomposed by probiotics in the mouth, it can also inhibit oral pathogenic bacteria, thereby playing a role in protecting teeth and resisting tooth decay.

[0070] Lysozyme is widely present in the animal, plant and microbial kingdoms, and is abundant in the tears, saliva, milk, blood, body fluids and internal organs of animals.

[0071] Lysozyme has the following advantages: (1) comprehensively improves the immunity of animals; (2) kills harmful bacteria, promotes the proliferation of beneficial bacteria, and improves the balance of intestinal flora; (3) promotes the repair of damaged tissues and alleviates inflammatory symptoms; (4) penetrates the reproductive barrier, cuts off vertical infection between mother and offspring, and protects both mother and offspring generations; (5) prevents and controls viral infections.

[0072] Wild chrysanthemum has the effects of clearing away heat and detoxifying, dispersing wind and calming the liver. It is mainly used to treat erysipelas, eczema, and sore throat.

[0073] Honeysuckle is cold in nature and sweet in taste, and has the effects of cooling and dispersing wind-heat, clearing away heat and detoxifying.

[0074] Honeysuckle contains chlorogenic acid, which has obvious therapeutic effects on acute pharyngitis and skin diseases, and has a strong inhibitory and killing effect on many pathogenic bacteria such as Staphylococcus aureus, hemolytic Streptococcus, Salmonella typhi, Shigella dysenteriae, Pneumococcus, etc.

[0075] Wild chrysanthemum and honeysuckle are used together to clear away heat and reduce internal heat, inhibit bacteria and disinfect, and are effective in treating acute tonsils, upper respiratory inflammation, and bacterial dysentery.

[0076] Marigold has anti-inflammatory, antioxidant, vision protection, and immunity enhancement effects. Honeysuckle contains lutein, which has biological effects such as improving the body's antioxidant capacity, lowering blood lipid levels, and improving the body's immune system function.

[0077] Studies have shown that adding 300g / kg of marigold extract to blue cats daily can improve their immunity, and adding marigold extract at different concentrations can improve the body's antioxidant capacity.

[0078] In other embodiments, other types of supplements may be used to provide other effects.

[0079] Preferably, in this embodiment, the orally dissolving film for pets further comprises 20 to 50 parts of a second film-forming agent, and the second film-forming agent comprises modified starch, pullulan and maltodextrin.

[0080] Specifically, the modified starch is selected from at least one of acetate starch, oxidized starch and hydroxypropyl starch.

[0081] Modified starch also has a disintegrating effect, and the increase of modified starch is also beneficial to the disintegration of the pet orodispersible film in the mouth.

[0082] Furthermore, in combination with the specific embodiments, the pet orodispersible film of the present invention also has the advantages of improving pet bad breath, reducing the growth of dental plaque, and cleaning the oral cavity.

[0083] The present invention also discloses a method for preparing the above-mentioned pet orally dissolving film according to an embodiment, comprising the following steps:

[0084] According to the mass proportions, 3 to 10 parts of pet flavoring agent and 20 to 50 parts of water are heated to 95 to 100° C. and kept warm for 25 to 45 minutes, then cooled to 40 to 55° C., 20 to 50 parts of the first film-forming agent are added, 0.5 to 1.5 parts of a pH regulator, 0.5 to 5 parts of a disintegrant and 10 to 20 parts of a supplement are added after mixing evenly, and after mixing evenly again, film spreading, drying, demoulding, cutting and packaging are performed in sequence to obtain the pet orosoluble film.

[0085] Preferably, the pet flavoring agent includes monosaccharide or syrup, amino acid, vitamin B1 and yeast. The pet flavoring agent and water are heated to 95°C to 100°C and kept warm for 25min to 45min, so that the monosaccharide or syrup, amino acid, vitamin B1 and yeast undergo Maillard reaction to produce flavor and nutritional factors, thereby preparing a mouth-dissolving film with good palatability for various oral nutritional supplements.

[0086] Combination Figure 1 The present invention also discloses another embodiment of a method for preparing the above-mentioned pet orodispersible film, comprising the following steps:

[0087] S10. Mix 20 to 50 parts of the first film-forming agent and 20 to 50 parts of the second film-forming agent according to their mass fractions, heat to 60° C. to 80° C., and stir evenly to obtain a film-forming mixture.

[0088] The first film-forming agent and the second film-forming agent are mixed, heated to 60° C. to 80° C. and stirred evenly, and the obtained film-forming mixture is a basic film functional mixture.

[0089] S20. Heat 3 to 10 parts of pet flavoring agent and 20 to 50 parts of water to 95 to 100°C according to their mass proportions and keep them warm for 25 to 45 minutes, then cool to 40 to 55°C and add the film-forming mixture, mix well, add 0.5 to 1.5 parts of pH regulator, 0.5 to 5 parts of disintegrant and 10 to 20 parts of supplement, mix well again, spread the film, dry, demould, cut and package in sequence to obtain the pet orosoluble film.

[0090] Preferably, the pet flavoring agent includes monosaccharide or syrup, amino acid, vitamin B1 and yeast. The pet flavoring agent and water are heated to 95°C to 100°C and kept warm for 25min to 45min, so that the monosaccharide or syrup, amino acid, vitamin B1 and yeast undergo Maillard reaction to produce flavor and nutritional factors, thereby preparing a mouth-dissolving film with good palatability for various oral nutritional supplements.

[0091] The following are specific embodiments.

[0092] In a specific embodiment, wolfberry is fresh wolfberry from Ningxia with a sugar content of 35%, cellulase, papain and lysozyme are all purchased from Novozymes, and oral ADP-1 probiotics are purchased from Jingyue Biotechnology Co., Ltd.

[0093] Example 1

[0094] 100g of wolfberry was crushed and added with 1000mL of water, 5g of vitamin C and 5g of enzyme, followed by mixed enzymolysis at pH 6 and 55°C for 3h. After the reaction was completed, the liquid phase was separated and concentrated at a concentration density of 1.35-1.4 to obtain wolfberry polysaccharide extract, in which the enzymes were cellulase and papain in a ratio of 2:1.

[0095] 5 g of pet flavoring agent (xylose, threonine, lysine, glycine, L-cysteine ​​and methionine and fermented beer yeast powder in a mass ratio of 15:0.3:0.4:0.8:0.6:2) and 30 g of water are mixed and heated to 100°C and kept warm for 35 minutes. The reaction solution is cooled to 50°C and 30 g of the above-prepared wolfberry polysaccharide extract is added, and the mixture is stirred and mixed evenly. Then, 1.5 g of sodium pyrophosphate, 0.2 g of citric acid, 1 g of sodium carboxymethyl starch, 5.5 g of chrysanthemum plant extract, 6 g of lysozyme and 5 g of tea polyphenols are added, and the mixture is stirred and mixed evenly for 20 minutes. 3 g of B vitamins, 2 g of catnip and 1 g of oral ADP-1 probiotics are added and stirred and mixed for 5 minutes. Finally, the film is spread, dried, demolded, cut and packaged to obtain the desired pet orodispersible film.

[0096] Example 2

[0097] 100g of wolfberry was crushed and added with 1000mL of water, 5g of vitamin C and 5g of enzyme, followed by mixed enzymolysis at pH 6 and 55°C for 3h. After the reaction was completed, the liquid phase was separated and concentrated at a concentration density of 1.35-1.4 to obtain wolfberry polysaccharide extract, in which the enzymes were cellulase and papain in a ratio of 2:1.

[0098] 30 g of the prepared wolfberry polysaccharide extract, 22.5 g of acetate starch, 15 g of pullulan and 10 g of maltodextrin were mixed, heated to 70° C. and stirred for 40 minutes to obtain a film-forming mixture.

[0099] 5 g of pet flavoring agent (xylose, threonine, lysine, glycine, L-cysteine ​​and methionine and fermented beer yeast powder in a mass ratio of 15:0.3:0.4:0.8:0.6:2) and 30 g of water are mixed and heated to 100°C and kept warm for 35 minutes. The reaction solution is cooled to 50°C and the film-forming mixture prepared above is added, and the mixture is stirred and mixed evenly. Then, 1.5 g of sodium pyrophosphate, 0.2 g of citric acid, 1 g of sodium carboxymethyl starch, 5.5 g of chrysanthemum plant extract, 6 g of lysozyme and 5 g of tea polyphenols are added, and the mixture is stirred and mixed evenly for 20 minutes. 3 g of B vitamins, 2 g of catnip and 1 g of oral ADP-1 probiotics are added and stirred and mixed for 5 minutes. Finally, the film is spread, dried, demolded, cut and packaged to obtain the required pet orodispersible film.

[0100] Comparative Example 1

[0101] 5 g of pet flavoring agent (xylose, threonine, lysine, methionine and fermented beer yeast powder in a mass ratio of 15:0.3:0.4:0.8:2) and 30 g of water were mixed and heated to 100°C and kept warm for 35 minutes. The reaction solution was cooled to 50°C and 30 g of wolfberry extract containing wolfberry polysaccharides (Ningxia wolfberry extract purchased from Shaanxi Yinuo Biotechnology Co., Ltd., item number 009) was added and stirred to mix evenly. Then 1.5 g of sodium pyrophosphate, 0.2 g of citric acid, 1 g of sodium carboxymethyl starch, 5.5 g of chrysanthemum plant extract, 6 g of lysozyme and 5 g of tea polyphenols were added and stirred to mix evenly for 20 minutes. 3 g of B vitamins, 2 g of catnip and 1 g of oral ADP-1 probiotics were added and stirred for 5 minutes. Finally, the film was spread, dried, demolded, cut and packaged to obtain the required pet orodispersible film.

[0102] Test Case

[0103] 1) The film-forming properties of the orally dissolving pet films prepared in Example 1 and the comparative example were compared.

[0104] The test results are as follows:

[0105] The mixed liquid of Example 1 spreads the film without abnormality, can form a smooth and uniform film, and is demoulded smoothly without deformation.

[0106] The mixed liquid of the comparative example had holes of varying sizes during the film spreading process and could not form a complete film.

[0107] It can be seen from this that the Lycium barbarum polysaccharide extract used in Example 1 has better film-forming properties than commercially available Lycium barbarum polysaccharides.

[0108] 2) Feeding test of the pet orodissolving film prepared in Example 2 and commercially available pet orodissolving films.

[0109] 50 dogs with oral problems, aged 1 to 12 years old, weighing 5 to 40 kg, and 50 cats with oral problems, aged 1.5 to 10 years old, weighing 4 to 8 kg, were selected and divided into two groups and fed with the pet orodispersible film prepared in Example 2 and a commercially available pet orodispersible film, respectively, once a day, 150 mg each time.

[0110] Among them, the clinical manifestations of cats / dogs with oral problems include difficulty swallowing, bad breath, drooling, weight loss, severe oral discomfort, oral bleeding, dull coat and difficulty breathing.

[0111] After one week of continuous feeding, the test results are shown in Table 1 below.

[0112]

[0113] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A pet orodispersible film, characterized in that: In terms of weight, it comprises 20 to 50 parts of a first film-forming agent, 0.5 to 1.5 parts of a pH adjuster, 3 to 10 parts of a pet flavoring agent, 0.5 to 5 parts of a disintegrant, and 10 to 20 parts of a supplement; The first film-forming agent is wolfberry polysaccharide extract.

2. The pet orally dissolving film according to claim 1, characterized in that: The preparation method of the wolfberry polysaccharide extract is as follows: after the wolfberry is crushed, water, enzyme and vitamin C are added according to the solid-liquid ratio of 0.5g-2g:10mL, followed by mixing and enzymolysis for 0.5h-5h under the conditions of pH 5.5-6.5 and temperature 50°C-65°C, after the reaction is completed, the liquid phase is separated, and the liquid phase is concentrated at a concentration density of 1.35-1.4 to obtain the wolfberry polysaccharide extract, wherein the enzyme is used in an amount of 0.25wt%-1wt%, the vitamin C is used in an amount of 0.2wt%-1wt%, and the enzyme includes cellulase and papain.

3. The pet orally dissolving film according to claim 2, characterized in that: In the enzyme, the ratio of the cellulase to the papain is 1 to 3:

1.

4. The pet orally dissolving film according to claim 2, characterized in that: The pH of the pet orodispersible film is 8 to 10; The pH adjuster is selected from at least one of tetrasodium pyrophosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium carbonate, sodium bicarbonate, citric acid and lactic acid.

5. The orodispersible film for pets according to claim 2, characterized in that: The pet flavoring agent includes monosaccharide or syrup, amino acid, vitamin B1 and yeast.

6. The orodispersible film for pets according to claim 5, characterized in that: The mass ratio of the monosaccharide or syrup, the amino acid, the vitamin B1 and the yeast is 10-20: 1-1.9: 0.2-1: 1-3; The monosaccharide is selected from at least one of xylose and ribose, the amino acid is selected from at least one of threonine, lysine, glycine, L-cysteine ​​and methionine, and the yeast is fermented beer yeast powder.

7. The orodispersible film for pets according to claim 2, characterized in that: The disintegrant is selected from at least one of sodium carboxymethyl starch, cross-linked polyvinyl pyrrolidone and cross-linked sodium carboxymethyl cellulose; The supplements include tea polyphenols, theaflavins, mint, catnip, lysozyme, chrysanthemum plant extracts, B vitamins and oral probiotics.

8. The orodissolving film for pets according to any one of claims 1 to 7, characterized in that: The pet orally dissolving film further comprises 20 to 50 parts of a second film-forming agent, wherein the second film-forming agent comprises modified starch, pullulan and maltodextrin.

9. A method for preparing a pet orally dissolving film according to any one of claims 1 to 7, characterized in that: The steps include: According to the mass proportions, 3 to 10 parts of pet flavoring agent and 20 to 50 parts of water are heated to 95 to 100° C. and kept warm for 25 to 45 minutes, then cooled to 40 to 55° C., 20 to 50 parts of the first film-forming agent are added, 0.5 to 1.5 parts of a pH regulator, 0.5 to 5 parts of a disintegrant and 10 to 20 parts of a supplement are added after mixing evenly, and after mixing evenly again, film spreading, drying, demoulding, cutting and packaging are performed in sequence to obtain the pet orosoluble film.

10. A method for preparing the orosoluble film for pets according to claim 8, characterized in that: The steps include: According to the weight ratio, 20 to 50 parts of the first film-forming agent and 20 to 50 parts of the second film-forming agent are mixed, heated to 60° C. to 80° C., and stirred evenly to obtain a film-forming mixture; According to the weight ratio, 3 to 10 parts of pet flavoring agent and 20 to 50 parts of water are heated to 95 to 100°C and kept warm for 25 to 45 minutes, then cooled to 40 to 55°C, the film-forming mixture is mixed evenly, 0.5 to 1.5 parts of pH regulator, 0.5 to 5 parts of disintegrant and 10 to 20 parts of supplement are added, mixed evenly again, film spreading, drying, demoulding, cutting and packaging are carried out in sequence to obtain the pet orosoluble film.

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