A Chinese medicine composition for preventing or treating prostate diseases and its preparation method and application

Abstract

The present invention discloses a Chinese medicine composition for preventing or treating prostate diseases, a preparation method and application thereof, and relates to the technical field of compositions. The Chinese medicine composition comprises space blue lavender essential oil, wormwood essential oil, ginseng extract and chuanxiong extract. The Chinese medicine composition of the present invention is an external medicine with good safety, has good therapeutic effects on prostate diseases such as prostate hyperplasia, prostatitis, prostate cancer and prostate stones, and has simple ingredients, low cost, and is more suitable for clinical promotion and application.

Description

Technical Field

[0001] The present invention belongs to the technical field of Chinese medicine compositions, and in particular, relates to a Chinese medicine composition for preventing or treating prostate diseases, and a preparation method and application thereof. Background Art

[0002] Benign prostatic hyperplasia (BPH) is a common physiological disease in elderly men. Its incidence is increasing, posing a threat to their physical and mental health.

[0003] At present, there are many pollen preparations (the main active ingredients are sterols) such as Prolean and Pushitai for the treatment of prostate diseases in China. Although they have clinical therapeutic value, the content of total sterols and other active ingredients in pollen is low, especially the content of β-sitosterol, campesterol, stigmasterol and cycloartenol is almost undetectable, resulting in large daily dosage for patients, making clinical application inconvenient.

[0004] Essential oils are a type of volatile mixture with a special aromatic smell and containing natural bioactive compounds. They are not only safe, highly biocompatible, and rapidly effective, but also have analgesic, anti-inflammatory, antioxidant, anti-mutagenic, anti-angiogenic, anti-proliferative effects, can enhance the immune system, and regulate multidrug resistance mechanisms. They show great application potential in the treatment of prostate diseases.

[0005] At present, there are few studies on the topical use of essential oils to prevent or treat prostate diseases. CN107019753A discloses a topical essential oil composition for treating prostate hyperplasia and its preparation method. The topical essential oil is mainly composed of 1-25 parts of agarwood essential oil, 1-20 parts of tribulus essential oil, 1-15 parts of patchouli essential oil, 1-15 parts of bergamot essential oil, 1-15 parts of wormwood essential oil, 1-10 parts of white pepper essential oil, 1-10 parts of oriental cypress essential oil, 1-10 parts of angelica essential oil, 1-5 parts of dodder seed essential oil, 1-5 parts of motherwort essential oil and 1-5 parts of cyperus rotundus essential oil by weight. Clinical trials have shown that the total effective rate of the topical essential oil in treating prostate hyperplasia is 97.6%, with significant effects and no side effects. However, the invention has complex ingredients and high costs, and is not suitable for clinical promotion and application. Summary of the invention

[0006] In order to solve the above technical problems, the present invention provides a Chinese medicine composition for preventing or treating prostate diseases, and a preparation method and application thereof. The Chinese medicine composition of the present invention is an external medicine with good safety, and has a good therapeutic effect on prostate diseases such as prostate hyperplasia, prostatitis and prostate stones. It also has simple ingredients and low cost, and is more suitable for clinical promotion and application.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a traditional Chinese medicine composition for preventing or treating prostate cell diseases, comprising space blue lavender essential oil, wormwood essential oil, ginseng extract and chuanxiong extract.

[0009] In some embodiments, the weight ratio of the wormwood essential oil, ginseng extract and Chuanxiong extract is 20-50:5-15:20-50; preferably 30-40:5-10:20-30; most preferably 35:8:25.

[0010] In some embodiments, the Chinese medicine composition includes the following raw materials by weight: 2-20 parts of space blue lavender essential oil, 20-50 parts of wormwood essential oil, 5-15 parts of ginseng extract and 20-50 parts of Chuanxiong extract.

[0011] In some embodiments, the Chinese medicine composition includes the following raw materials by weight: 2-10 parts of space blue lavender essential oil, 30-40 parts of mugwort essential oil, 5-10 parts of ginseng extract and 20-30 parts of Chuanxiong extract.

[0012] In some embodiments, the Chinese medicine composition includes the following raw materials by weight: 5 parts of space blue lavender essential oil, 35 parts of mugwort essential oil, 8 parts of ginseng extract and 25 parts of Chuanxiong extract.

[0013] In a second aspect, the present invention provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps: mixing a formula amount of space blue lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract.

[0014] In a third aspect, the present invention provides the use of space blue lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract in the preparation of a drug for preventing or treating prostate diseases.

[0015] In some embodiments, the prostate disease includes at least one of prostate hyperplasia, prostatitis, prostate cancer and prostate stones.

[0016] In some embodiments, the weight ratio of space blue lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract in the application is 2-20:20-50:5-15:20-50; preferably 2-10:30-40:5-10:20-30; most preferably 5:35:8:25.

[0017] In a fourth aspect, the present invention provides a medicine for preventing or treating prostate cell diseases, which is prepared from the above-mentioned Chinese medicine composition and auxiliary materials.

[0018] The medicine is for external use, including ointment, spray, liniment, tincture, patch, wet compress, gel or lotion.

[0019] The beneficial effects of the present invention are:

[0020] (1) Experiments show that the present invention utilizes a combination of four active ingredients, namely, space blue lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract, to produce a synergistic effect in inhibiting the proliferation of prostate cancer cells and prostate hyperplasia, and can be used for the prevention and treatment of prostate cancer and prostate hyperplasia.

[0021] (2) The Chinese medicine composition of the present invention is an external medicine with good safety and has a good therapeutic effect on prostate diseases such as prostate hyperplasia, prostatitis and prostate stones.

[0022] (3) Compared with the prior art, the invention has simple ingredients and low cost, and is more suitable for clinical promotion and application. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 The therapeutic effect of the Chinese medicine composition on prostatic hyperplasia,

[0024] Among them, A is the effect of the Chinese medicine composition on the body weight of mice, B is the effect of the Chinese medicine composition on the prostate weight of mice, and C is the effect of the Chinese medicine composition on the prostate index of mice. DETAILED DESCRIPTION

[0025] The following examples are only used to help understand the method of the present invention and its core idea. It should be noted that for those of ordinary skill in the art, without departing from the principles of the present invention, the present invention may also be subjected to several improvements and modifications, which also fall within the scope of protection of the claims of the present invention. The following description of the disclosed embodiments enables professionals and technicians in this field to implement or use the present invention. It will be apparent to professionals and technicians in this field that various modifications to these embodiments, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but may be applied to a wider range consistent with the principles and novel features disclosed herein. Although any methods and materials similar or equivalent to those described in the present invention may be used in the implementation or testing of the present invention, preferred methods and materials are listed herein.

[0026] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0027] The raw materials used in the present invention are all conventional commercially available products, so the present invention does not limit the sources of the raw materials. The specific raw material information is shown in Table 1.

[0028] Table 1 Raw material information

[0029]

[0030] Example 1 Chinese medicine composition for preventing or treating prostate diseases

[0031] The formula of the Chinese medicine composition (by weight) includes 5 parts of space blue lavender essential oil, 35 parts of wormwood essential oil, 8 parts of ginseng extract and 25 parts of Chuanxiong extract.

[0032] The preparation method is as follows: evenly mix the space blue lavender essential oil, wormwood essential oil, ginseng extract and chuanxiong extract in the formula amount.

[0033] Example 2 Chinese medicine composition for preventing or treating prostate diseases

[0034] The formula of the Chinese medicine composition (by weight) includes: 2 parts of space blue lavender essential oil, 30 parts of wormwood essential oil, 5 parts of ginseng extract and 20 parts of Chuanxiong extract.

[0035] The preparation method is the same as Example 1.

[0036] Example 3 Chinese medicine composition for preventing or treating prostate diseases

[0037] The formula of the Chinese medicine composition (by weight) includes the following raw materials: 10 parts of space blue lavender essential oil, 40 parts of wormwood essential oil, 10 parts of ginseng extract and 30 parts of Chuanxiong extract.

[0038] The preparation method is the same as Example 1.

[0039] Example 4 Chinese medicine composition for preventing or treating prostate diseases

[0040] The formula of the Chinese medicine composition (by weight) includes: 20 parts of space blue lavender essential oil, 50 parts of wormwood essential oil, 15 parts of ginseng extract and 50 parts of Chuanxiong extract.

[0041] The preparation method is the same as Example 1.

[0042] Example 5 Chinese medicine composition for preventing or treating prostate diseases

[0043] The formula of the Chinese medicine composition (by weight) includes the following raw materials: 15 parts of space blue lavender essential oil, 20 parts of wormwood essential oil, 5 parts of ginseng extract and 20 parts of Chuanxiong extract.

[0044] The preparation method is the same as Example 1.

[0045] Comparative Example 1: Traditional Chinese medicine composition for preventing or treating prostate diseases

[0046] The difference between this comparative example and Example 1 is that there is no Chuanxiong extract.

[0047] The formula of the Chinese medicine composition (by weight) includes 5 parts of space blue lavender essential oil, 35 parts of wormwood essential oil and 8 parts of ginseng extract.

[0048] The preparation method is as follows: evenly mix the space blue lavender essential oil, wormwood essential oil and ginseng extract in the formula amount.

[0049] Comparative Example 2: Traditional Chinese medicine composition for preventing or treating prostate diseases

[0050] The difference between this comparative example and Example 1 is that it only contains Chuanxiong extract.

[0051] The formula of the Chinese medicine composition (by weight) includes: 20 parts of Chuanxiong extract.

[0052] The preparation method is as follows: 20 parts by weight of Chuanxiong extract and 40 parts by weight of water are uniformly mixed.

[0053] Comparative Example 3: Traditional Chinese medicine composition for preventing or treating prostate diseases

[0054] The difference between this comparative example and Example 1 is that the usage relationship of the wormwood essential oil, the ginseng extract and the chuanxiong extract is different.

[0055] The formula of the Chinese medicine composition (by weight) includes 5 parts of space blue lavender essential oil, 35 parts of wormwood essential oil, 25 parts of ginseng extract and 8 parts of Chuanxiong extract.

[0056] The preparation method is the same as Example 1.

[0057] 1. Inhibitory effect on the growth and proliferation of human prostate cancer cell PC-3

[0058] 1. Cell Counting Kit 8 (CCK8) to detect cell proliferation

[0059] (1) Select human prostate cancer cells PC-3 that are in good growth condition and in the logarithmic growth phase, digest them with trypsin, add complete medium containing 10% FBS to terminate the digestion, pipette into a cell suspension and transfer to a centrifuge tube, centrifuge at 1500 g for 3 min, discard the supernatant, and add complete medium to make a cell suspension;

[0060] (2) Count the cells using a cell counting plate. Inoculate 5,000 cells in 96-well plates with 6 replicate wells per group of cells at a volume of 100 μL per well. Add an equal amount of PBS solution to the wells on the edges to prevent edge effects.

[0061] (3) Incubate in a conventional culture medium at 37°C, 5% CO2 incubator overnight; remove the liquid culture medium from each well, prepare a culture medium containing a Chinese medicine composition of different concentrations, and add it to each well for continued culture;

[0062] (4) After 24 h of incubation, remove the culture medium from the well plate, prepare the CCK8 solution required for the experiment under light-proof conditions, add 100 μL of CCK8 solution to each well, and incubate in the incubator for 1-3 h;

[0063] (5) Adjust the wavelength of the automatic microplate reader to 450 nm and 630 nm, and measure the OD value of each well;

[0064] (6) The growth curve of each group of cells was drawn according to the OD value, and Graphpad 8.0 was used to calculate and analyze the cell growth and proliferation.

[0065] The CCK8 method was used to detect the effects of different concentrations of the Chinese medicine composition prepared in Example 1 on the proliferation of human prostate cancer cells PC-3. The results are shown in Table 2.

[0066] Table 2 Inhibitory effects of different concentrations of the Chinese medicine composition prepared in Example 1 on the growth and proliferation of human prostate cancer cells PC-3

[0067]

[0068] The results showed that the proliferation inhibition rate of PC-3 cells after being treated with 0.001, 0.01 and 0.1 (v / v) of the Chinese medicine composition was more than 99.5%, indicating that the Chinese medicine composition prepared in Example 1 can effectively inhibit the proliferation of PC-3 prostate cancer cells with obvious dose dependence.

[0069] The CCK8 method was used to detect the inhibitory effects of the Chinese medicine compositions prepared in different embodiments and comparative examples on PC-3 cells. The results are shown in Table 3.

[0070] Table 3 Inhibitory effects of the Chinese medicine compositions prepared in different examples and comparative examples on the growth and proliferation of prostate cancer cells PC-3

[0071]

[0072] The results showed that the Chinese medicine compositions prepared in different examples and comparative examples had different inhibitory effects on PC-3 cells. The IC values ​​of the Chinese medicine compositions prepared in Examples 1-5 were 50 The values ​​were 0.00019-0.00937 (v / v), among which Example 1 had the best inhibitory effect, IC 50 The value is the smallest.

[0073] Comparison of Example 1 with Comparative Examples 1 and 2 shows that, in the technical solution claimed in the present invention, the Chinese medicine composition prepared by the combination of lavender essential oil, wormwood essential oil and ginseng extract or the single Chuanxiong extract has a poor inhibitory effect on PC-3 cells, IC 50 Compared with the combination of lavender essential oil, wormwood essential oil and ginseng extract or the single Chuanxiong extract, Example 1 of the present invention uses lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract to cooperate with each other, which produces a synergistic effect in inhibiting the proliferation of PC-3 prostate cancer cells, IC 50 It is 0.00019.

[0074] Comparison of Example 1 with Comparative Example 3 shows that in the technical solution claimed by the present invention, the conventional amount of lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract is combined, and its inhibitory effect on PC-3 cells is poor, IC 50 It is 0.0237, and synergistic effect cannot be achieved.

[0075] 2. Inhibitory effect on the growth and proliferation of human prostate cancer cell DU145

[0076] Cell Counting Kit 8 (CCK8) to detect cell proliferation

[0077] (1) Select human prostate cancer cells DU145 that are in good growth condition and in the logarithmic growth phase, digest them with trypsin, add complete medium containing 10% FBS to terminate the digestion, pipette into a cell suspension and transfer to a centrifuge tube, centrifuge at 1500 g for 3 min, discard the supernatant, and add complete medium to make a cell suspension;

[0078] (2) Count the cells using a cell counting plate. Inoculate 5,000 cells in 96-well plates with 6 replicate wells per group of cells at a volume of 100 μL per well. Add an equal amount of PBS solution to the wells on the edges to prevent edge effects.

[0079] (3) Incubate in a conventional culture medium at 37°C, 5% CO2 incubator overnight; remove the liquid culture medium from each well, prepare a culture medium containing a Chinese medicine composition of different concentrations, and add it to each well for continued culture;

[0080] (4) After 24 h of incubation, remove the culture medium from the well plate, prepare the CCK8 solution required for the experiment under light-proof conditions, add 100 μL of CCK8 solution to each well, and incubate in the incubator for 1-3 h;

[0081] (5) Adjust the wavelength of the automatic microplate reader to 450 nm and 630 nm, and measure the OD value of each well;

[0082] (6) The growth curve of each group of cells was drawn according to the OD value, and Graphpad 8.0 was used to calculate and analyze the cell growth and proliferation.

[0083] The CCK8 method was used to detect the effects of different concentrations of the Chinese medicine composition prepared in Example 1 on the proliferation of human prostate cancer cell DU145. The results are shown in Table 4.

[0084] Table 4 Inhibitory effect of the Chinese medicine composition prepared in Example 1 at different concentrations on the growth and proliferation of human prostate cancer cell DU145

[0085]

[0086] The results showed that when the concentration of the Chinese medicine composition was 0.001 (v / v), the cell proliferation inhibition rate was about 90%, indicating that the Chinese medicine composition prepared in Example 1 can effectively inhibit the proliferation of human prostate cancer cell DU145 and has obvious dose dependence.

[0087] The CCK8 method was used to detect the inhibitory effects of the Chinese medicine compositions prepared in different embodiments and comparative examples on human prostate cancer cell DU145. The results are shown in Table 5.

[0088] Table 5 Inhibitory effects of the Chinese medicine compositions prepared in different examples and comparative examples on the growth and proliferation of prostate cancer cell DU145

[0089]

[0090] The results showed that the Chinese medicine compositions prepared in different examples and comparative examples had different inhibitory effects on human prostate cancer cell DU145. The IC values ​​of the Chinese medicine compositions prepared in Examples 1-5 were 50 The values ​​were 0.00067-0.00867 (v / v), among which Example 1 had the best inhibitory effect, IC 50 The value is the smallest.

[0091] Comparison of Example 1 with Comparative Examples 1 and 2 shows that, in the technical solution claimed in the present invention, the Chinese medicine composition prepared by the combination of lavender essential oil, wormwood essential oil and ginseng extract or the single Chuanxiong extract has a poor inhibitory effect on DU145 cells, IC 50 In Example 1 of the present invention, lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract cooperate with each other to produce a synergistic effect in inhibiting the proliferation of DU145 prostate cancer cells. IC 50 It is 0.00067.

[0092] Comparison of Example 1 with Comparative Example 3 shows that in the technical solution claimed by the present invention, the combination of conventional amounts of lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract has a poor inhibitory effect on DU145 cells, IC 50 It is 0.0597, and the synergistic effect cannot be achieved.

[0093] 3. The therapeutic effect of Chinese medicine combination on prostatic hyperplasia

[0094] The therapeutic effect of the Chinese medicine composition of the present invention on prostate hyperplasia was investigated by using a prostate hyperplasia mouse model induced by testosterone propionate.

[0095] After one week of adaptive culture, 7-week-old C57BL / 6 male mice were randomly divided into a control group, a model group, Example 1-Example 5 groups, and Comparative Example 1-Comparative Example 3 groups, with 5 mice in each group. Except for the control group, the remaining groups were continuously injected with testosterone propionate (TP, dissolved in 100 μL corn oil; Cat. No. C805618, Macklin) intraperitoneally at a dose of 5 mg / kg per day; the control group was injected with an equal volume of corn oil. On the day of modeling, the treatment group was administered with the same volume of saline applied to the skin near the prostate according to Examples 1-5 and Comparative Examples 1-3, while the model group and the control group were administered with the same volume of saline. After 28 days of continuous administration, the mice were killed, and the prostate tissues were collected and weighed for comparison.

[0096] The results are as follows Figure 1 shown.

[0097] The results showed that compared with the control group, the prostate index of the model group mice was significantly increased (P < 0.01), indicating that intraperitoneal injection of testosterone propionate caused the prostate of the mice to increase significantly and the model was successfully established.

[0098] Compared with the model group, the prostate index of mice in Example 1-5 groups and Comparative Example 1 group decreased significantly (P < 0.05), and there was no statistical difference in the prostate index of mice in Comparative Example 2-3 groups (P > 0.05), indicating that the Chinese medicine compositions provided in Examples 1-5 and Comparative Example 1 of the present invention have anti-prostate hyperplasia effects, and the Chinese medicine compositions provided in Comparative Examples 2-3 have poor anti-prostate hyperplasia effects.

[0099] Compared with Example 2-5 and Comparative Example 1, the prostate index of mice in Example 1 was significantly decreased (P < 0.05), indicating that the Chinese medicine composition prepared in Example 1 of the present invention has a significantly better effect on anti-prostatic hyperplasia than Examples 2-5 and Comparative Example 1.

[0100] 4. Application Effect

[0101] Su, who suffered from prostatitis, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in February 2022. After one month of treatment, he reported that the inflammation had disappeared.

[0102] Fu, who suffered from prostatitis, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in June 2022. After one month of treatment, he reported recovery.

[0103] Qian, who suffered from prostatitis, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in June 2022. After 2 weeks of treatment, he reported recovery.

[0104] Zheng, who suffers from prostatitis, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in February 2023. After 3 weeks of treatment, he reported that his urinary urgency and frequent urination had improved, and his urine dripping had improved.

[0105] Mr. Gong, who suffered from mild prostatic hypertrophy, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in May 2021. After 3 months of treatment, he reported recovery.

[0106] Mr. Ni, who suffered from severe prostatic hypertrophy, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in May 2021. After 6 months of treatment, he reported recovery.

[0107] Mr. Liu, who suffers from prostate hyperplasia, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in August 2022. He was treated for 2 months and reported that the effect was obvious.

[0108] Xie, who suffers from prostate hypertrophy, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in March 2023 for half a month of treatment. He reported that the anti-inflammatory effect was obvious and the testicles tightened after half a month of use.

[0109] Mr. Qiu, who suffered from prostate hypertrophy, incomplete urination, and dripping, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in January 2023. After 2 months of treatment, he reported that the inflammation disappeared and his urination was smooth.

[0110] Ji, who suffered from prostate hyperplasia, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in June 2023. After 3 weeks of treatment, he reported that his urination improved, his urination was smooth and powerful, and the inflammation disappeared. He continued to use it to consolidate the effect.

[0111] Gu, who suffered from prostatic hyperplasia with stones and prostatic cysts, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in November 2022. After 3 months of treatment, he reported that there was improvement after use, his urination was smooth, inflammation disappeared, and he had fewer nighttime wake-ups.

[0112] Mr. Ge, who suffered from mild prostatic hyperplasia with calcification, began to apply the Chinese medicine composition prepared in Example 1 of the present invention externally in May 2022. After one month of treatment, he reported recovery.

[0113] The above is a further description of the present invention in conjunction with specific embodiments, but these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solution of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for preventing or treating prostatic hyperplasia, characterized in that: The invention is composed of the following raw materials by weight: 2-20 parts of space blue lavender essential oil, 20-50 parts of wormwood essential oil, 5-15 parts of ginseng extract and 20-50 parts of chuanxiong extract.

2. The Chinese medicine composition according to claim 1, characterized in that: The weight ratio of the wormwood essential oil, the ginseng extract and the chuanxiong extract is 30-40:5-10:20-30.

3. The Chinese medicine composition according to claim 1, characterized in that The weight ratio of the wormwood essential oil, the ginseng extract and the chuanxiong extract is 35:8:

25.

4. The Chinese medicine composition according to claim 1, characterized in that: The invention is composed of the following raw materials by weight: 2-10 parts of space blue lavender essential oil, 30-40 parts of wormwood essential oil, 5-10 parts of ginseng extract and 20-30 parts of chuanxiong extract.

5. The Chinese medicine composition according to claim 1, characterized in that: The invention is composed of the following raw materials by weight: 5 parts of space blue lavender essential oil, 35 parts of wormwood essential oil, 8 parts of ginseng extract and 25 parts of chuanxiong extract.

6. The method for preparing the Chinese medicine composition according to any one of claims 1 to 5, characterized in that: The method comprises the following steps: mixing the space blue lavender essential oil, wormwood essential oil, ginseng extract and chuanxiong extract in the prescribed amount.

7. Use of space blue lavender essential oil, wormwood essential oil, ginseng extract and Chuanxiong extract in the preparation of a drug for preventing or treating prostate diseases. The weight ratio of the space blue lavender essential oil, the wormwood essential oil, the ginseng extract and the chuanxiong extract is 2-20:20-50:5-15:20-50; The disease is prostate hyperplasia.

8. A drug for preventing or treating prostatic hyperplasia, characterized in that: The invention is prepared from the Chinese medicine composition according to any one of claims 1 to 5 and auxiliary materials.

9. The drug according to claim 8, characterized in that The medicine is for external use.

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