Traditional Chinese medicine composition with heart valve repairing effect as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition with a heart valve repairing effect and a preparation method and application thereof. The invention provides a traditional Chinese medicine composition with a heart valve repairing effect. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 18-22 parts of Chinese yam, 10-20 parts of prepared rehmannia root, 10-20 parts of radix rehmanniae recen, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of angelica sinensis, 10-20 parts of cortex moutan, 10-20 parts of caulis spatholobi, 8-12 parts of peach kernel, 8-12 parts of coptis chinensis, 8-12 parts of radix ophiopogonis, 8-12 parts of codonopsis pilosula, 8-12 parts of radix polygonati officinalis and 8-12 parts of semen boitae. The composition has the effects of tonifying spleen, regulating qi and nourishing heart and blood, is safe and non-toxic, can be continuously taken, and can relatively completely repair heart valve tissues and relieve further damage and malignant change of the tissues.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition having the effect of repairing heart valves, and a preparation method and application thereof. Background Art

[0002] Valvular heart disease refers to heart disease caused by stenosis and / or insufficiency of heart valves due to various reasons. Common causes include rheumatic fever, myxoid degeneration, valvular degeneration, congenital malformation, ischemic necrosis, trauma, etc. Although the prevalence of valvular heart disease caused by rheumatic fever is declining year by year, rheumatic fever is still the main cause of the disease.

[0003] Valvular heart disease is a common disease with clinical manifestations including palpitations, shortness of breath, weakness, tiredness, decreased activity tolerance, etc. In severe cases, it may also cause dyspnea, oliguria, and even orthopnea. It is mainly treated with surgical and interventional therapies. Those who are discovered and treated early generally have a better prognosis.

[0004] Cardiac color Doppler ultrasound is also the only instrument that can directly display valvular disease. Through the measurement of color Doppler ultrasound, doctors can understand the extent of valvular disease to decide whether to treat conservatively or surgically. In the detection of cardiac color Doppler ultrasound, mitral valve, tricuspid valve, pulmonary valve, and aortic valve regurgitation often occurs.

[0005] Regardless of the cause of valvular regurgitation, it always poses a certain degree of threat to human health. In addition to surgery when the condition is severe enough, there are no more effective drugs to improve this situation. There are many traditional Chinese medicine prescriptions for nourishing the heart, but there are very few related Chinese medicine preparations that can achieve precise maintenance and improvement of the valve. Therefore, those skilled in the art are in urgent need of providing a Chinese medicine preparation that can effectively treat heart valve disease. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition having the effect of repairing heart valves and a preparation method and application thereof.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] The invention provides a traditional Chinese medicine composition with the effect of repairing heart valves. The traditional Chinese medicine composition comprises the following components in parts by weight: 18-22 parts of yam, 10-20 parts of prepared rehmannia root, 10-20 parts of raw rehmannia root, 10-20 parts of salvia miltiorrhiza, 10-20 parts of angelica sinensis, 10-20 parts of moutan bark, 10-20 parts of millettia spatholobi, 8-12 parts of peach kernel, 8-12 parts of coptis root, 8-12 parts of ophiopogon japonicus, 8-12 parts of codonopsis pilosula, 8-12 parts of polygonatum odoratum and 8-12 parts of arborvitae seed.

[0009] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0010] (1) Mixing Chinese yam, prepared rehmannia root, raw rehmannia root, salvia miltiorrhiza, angelica sinensis, moutan bark, millettia spatholobi, peach kernel, coptis root, ophiopogon japonicus, codonopsis pilosula, polygonatum odoratum, and cypress seed to obtain material 1; mixing material 1 with water, soaking, decocting, and filtering to obtain a filtrate and a filter residue;

[0011] (2) mixing the filter residue obtained in step (1) with water and boiling, and filtering to obtain a decoction;

[0012] (3) Mixing the filtrate obtained in step (1) with the decoction obtained in step (2) to obtain a Chinese medicine composition.

[0013] Preferably, the mass ratio of the material 1 to water in step (1) is 1:3-4.

[0014] Preferably, the soaking time in step (1) is 25 to 35 minutes.

[0015] Preferably, the decocting time in step (1) is 15 to 25 minutes.

[0016] Preferably, the mass ratio of the filter residue to water in step (2) is 1:2-3.

[0017] Preferably, the cooking time in step (2) is 15 to 25 minutes.

[0018] The present invention also provides the use of the Chinese medicine composition or the Chinese medicine composition obtained by the preparation method in preparing a pharmaceutical preparation having the effect of repairing heart valves.

[0019] Preferably, the dosage form of the pharmaceutical preparation is a decoction, a fluid extract, a powder, a granule, a pill, a tablet or a capsule.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] The prescription of the present invention is based on medical experimental data and images, combined with traditional Chinese medicine methods, to provide a Chinese medicine composition with the effect of repairing heart valves. The prescription has the effects of strengthening the spleen, regulating qi, nourishing the heart and blood, and is safe, non-toxic, and can be taken continuously. Although the medication time is long, it can improve the body function more comprehensively, repair the heart valve tissue more completely, and slow down the further damage and malignant transformation of the tissue. Due to the age difference of different patients, the degree of damage to the heart valve caused by different inducements is different, and the time required for improvement is different. The prescription of the present invention generally takes effect in about three months.

[0022] Among the components added in the present invention, prepared rehmannia root, raw rehmannia root and angelica root are the main drugs for tonifying blood; salvia miltiorrhiza and cortex moutan cool blood and tonify blood, millettia spatholobi and peach kernel are the ministerial drugs for promoting blood circulation and tonifying blood; coptis root, ophiopogon and polygonatum odoratum are the adjuvant drugs for nourishing yin; codonopsis pilosula, cypress seed and yam are the guiding drugs for tonifying kidney and qi, and blood circulation when qi circulates.

[0023] The prescription of the present invention is suitable for patients with heart valve regurgitation caused by different reasons, has a stable treatment effect, does not cause any damage to the human body, and can simultaneously improve the functioning capacity of other internal organs. The materials are safe and easy to obtain, have little or no toxic side effects, and are simple to apply and operate. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0025] Figure 1 This is the diagnosis certificate result before treatment of Case 1D*.

[0026] Figure 2 This is the diagnosis certificate result after treatment of Case 1D*.

[0027] Figure 3 This is the diagnosis certificate result before treatment for Case 2 Ding * Fang.

[0028] Figure 4 This is the diagnosis certificate result after treatment for Case 2 Ding * Fang.

[0029] Figure 5 This is the diagnosis certificate result before treatment of Case 3 Jin*Yong.

[0030] Figure 6 This is the diagnosis certificate result after treatment of Case 3 Jin*Yong.

[0031] Figure 7 This is the diagnosis certificate result before treatment of Case 4 Li*Li.

[0032] Figure 8 This is the diagnosis certificate result after treatment for Case 4 Li*Li.

[0033] Fig. 9 This is the diagnosis certificate result of Case 5 Lin* before treatment.

[0034] Fig.10 This is the diagnostic result of Case 5 Lin* after treatment.

[0035] Fig.11 This is the diagnosis certificate result before Case 6*Ying’s treatment.

[0036] Fig.12 This is the diagnosis certificate result after Case 6 received treatment from Ying*Ying. DETAILED DESCRIPTION

[0037] The present invention provides a traditional Chinese medicine composition with the effect of repairing heart valves, which is prepared by comprising the following components in parts by weight: 18-22 parts of yam, 10-20 parts of prepared rehmannia root, 10-20 parts of raw rehmannia root, 10-20 parts of salvia miltiorrhiza, 10-20 parts of angelica, 10-20 parts of moutan bark, 10-20 parts of millettia spatholobi, 8-12 parts of peach kernel, 8-12 parts of coptis root, 8-12 parts of ophiopogon, 8-12 parts of codonopsis pilosula, 8-12 parts of polygonatum odoratum, and 8-12 parts of cypress seed; preferably 19-21 parts of yam, 12-18 parts of prepared rehmannia root, 12-18 parts of raw rehmannia root, 12-18 parts of salvia miltiorrhiza, 12-18 parts of angelica, 12-18 parts of moutan bark, 12-18 parts of millettia spatholobi, 9-11 parts of peach kernel, 9-11 parts of coptis root, 9-11 parts of ophiopogon, 9-11 parts of codonopsis, 9-11 parts of polygonatum, and 9-11 parts of arborvitae; further preferably 20 parts of yam, 14-16 parts of rehmannia root, 14-16 parts of raw rehmannia root, 14-16 parts of salvia miltiorrhiza, 14-16 parts of angelica, 14-16 parts of moutan bark, 14-16 parts of millettia spatholobi, 10 parts of peach kernel, 10 parts of coptis root, 10 parts of ophiopogon, 10 parts of codonopsis, 10 parts of codonopsis, 10 parts of polygonatum, and 10 parts of arborvitae; more preferably 20 parts of yam, 15 parts of rehmannia root, 15 parts of raw rehmannia root, 15 parts of salvia miltiorrhiza, 15 parts of angelica, 15 parts of moutan bark, 15 parts of millettia spatholobi, 10 parts of peach kernel, 10 parts of coptis root, 10 parts of ophiopogon, 10 parts of codonopsis, 10 parts of codonopsis, 10 parts of polygonatum, and 10 parts of arborvitae.

[0038] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0039] (1) Mixing Chinese yam, prepared rehmannia root, raw rehmannia root, salvia miltiorrhiza, angelica sinensis, moutan bark, millettia spatholobi, peach kernel, coptis root, ophiopogon japonicus, codonopsis pilosula, polygonatum odoratum, and cypress seed to obtain material 1; mixing material 1 with water, soaking, decocting, and filtering to obtain a filtrate and a filter residue;

[0040] (2) mixing the filter residue obtained in step (1) with water and boiling, and filtering to obtain a decoction;

[0041] (3) Mixing the filtrate obtained in step (1) with the decoction obtained in step (2) to obtain a Chinese medicine composition.

[0042] In the present invention, the mass ratio of the material 1 to water in step (1) is 1:3-4, preferably 1:3.

[0043] In the present invention, the soaking time in step (1) is 25 to 35 minutes, preferably 27 to 33 minutes, more preferably 29 to 31 minutes, and more preferably 30 minutes.

[0044] In the present invention, the decocting time in step (1) is 15 to 25 minutes, preferably 17 to 23 minutes, more preferably 19 to 21 minutes, and more preferably 20 minutes.

[0045] In the present invention, the mass ratio of the filter residue to water in step (2) is 1:2 to 3, preferably 1:2.

[0046] In the present invention, the cooking time in step (2) is 15 to 25 minutes, preferably 17 to 23 minutes, more preferably 19 to 21 minutes, and more preferably 20 minutes.

[0047] The present invention also provides the use of the Chinese medicine composition or the Chinese medicine composition obtained by the preparation method in preparing a pharmaceutical preparation having the effect of repairing heart valves.

[0048] In the present invention, the dosage form of the pharmaceutical preparation is a decoction, a fluid extract, a powder, a granule, a pill, a tablet or a capsule; preferably a decoction.

[0049] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0050] Example 1

[0051] A method for preparing a traditional Chinese medicine composition having the effect of repairing heart valves, comprising the following steps:

[0052] (1) 22 g of Chinese yam, 20 g of Rehmannia root, 20 g of Radix Rehmanniae, 20 g of Salvia miltiorrhiza, 20 g of Angelica sinensis, 20 g of Cortex Moutan, 20 g of Millettia spatholobi, 12 g of Semen Persicae, 12 g of Coptis chinensis, 12 g of Ophiopogon japonicus, 12 g of Codonopsis pilosula, 12 g of Polygonatum odoratum, and 12 g of Semen Platycladi were mixed to obtain material 1; the material 1 was mixed with water in a mass ratio of 1:4 and soaked for 35 min, then decocted for 25 min, and filtered to obtain a filtrate and a filter residue;

[0053] (2) mixing the filter residue obtained in step (1) with water in a mass ratio of 1:3 and boiling for 25 minutes, and filtering to obtain a decoction;

[0054] (3) Mixing the filtrate obtained in step (1) with the decoction obtained in step (2) to obtain a Chinese medicine composition.

[0055] Example 2

[0056] A method for preparing a traditional Chinese medicine composition having the effect of repairing heart valves, comprising the following steps:

[0057] (1) 18 g of yam, 10 g of prepared rehmannia root, 10 g of raw rehmannia root, 10 g of salvia miltiorrhiza, 10 g of angelica sinensis, 10 g of moutan bark, 10 g of millettia spatholobi, 8 g of peach kernel, 8 g of coptis root, 8 g of ophiopogon japonicus, 8 g of codonopsis pilosula, 8 g of polygonatum odoratum, and 8 g of cypress seed are mixed to obtain material 1; the material 1 is mixed with water in a mass ratio of 1:3 and soaked for 25 min, then decocted for 15 min, and filtered to obtain a filtrate and a filter residue;

[0058] (2) mixing the filter residue obtained in step (1) with water in a mass ratio of 1:2 and boiling for 15 minutes, and filtering to obtain a decoction;

[0059] (3) Mixing the filtrate obtained in step (1) with the decoction obtained in step (2) to obtain a Chinese medicine composition.

[0060] Example 3

[0061] A method for preparing a traditional Chinese medicine composition having the effect of repairing heart valves, comprising the following steps:

[0062] (1) 20 g of Chinese yam, 15 g of Rehmannia root, 15 g of Radix Rehmanniae, 15 g of Salvia miltiorrhiza, 15 g of Angelica sinensis, 15 g of Cortex Moutan, 15 g of Millettia spatholobi, 10 g of Semen Persicae, 10 g of Coptis chinensis, 10 g of Ophiopogon japonicus, 10 g of Codonopsis pilosula, 10 g of Polygonatum odoratum, and 10 g of Semen Platycladi were mixed to obtain material 1; the material 1 was mixed with water in a mass ratio of 1:3 and soaked for 30 min, then decocted for 20 min, and filtered to obtain a filtrate and a filter residue;

[0063] (2) mixing the filter residue obtained in step (1) with water in a mass ratio of 1:2 and boiling for 20 minutes, and filtering to obtain a decoction;

[0064] (3) Mixing the filtrate obtained in step (1) with the decoction obtained in step (2) to obtain a Chinese medicine composition.

[0065] Experimental Example 1

[0066] Case 1

[0067] Ding*, male, 40 years old, works as a lawyer. He has many friends and social events, has a drinking party every week, loves sports and fitness, and goes to the gym at least three times a week. In March 2018, a physical examination showed that a small amount of reflux signals were visible in the tricuspid valve, mitral valve, and pulmonary valve. The diagnosis was mild tricuspid, mitral, and pulmonary valve regurgitation. The physical examination also showed gastrointestinal damage and other conditions. In March 2019, system maintenance was started to take into account heart valve maintenance (the product obtained in Example 3, one dose per day). The total time was more than one year, during which the medication was intermittent, and the rhythm of life was the same. In March 2022, the heart was rechecked by color Doppler ultrasound, and only mild tricuspid valve regurgitation remained. It can be seen that this patent can effectively improve heart valves.

[0068] Case 2

[0069] Ding * Fang, female, 45 years old, business owner, works at a fast pace, with a heavy workload and many social engagements. In November 2019, a physical examination showed that the size of each chamber of the heart was normal, with a small amount of mitral and tricuspid regurgitation, decreased compliance of the left ventricular muscle, and normal left ventricular systolic function. There was also gastric damage during the physical examination. I attach great importance to health management. Although the problems in the physical examination results are not serious, I have a strong sense of prevention and hope to have a healthier body to enjoy work and life. In December 2019, systematic maintenance (the product obtained in Example 3, one dose per day) was started. After 6 months of continuous maintenance, I felt that my body had improved well and suspended maintenance. In January 2021, the cardiac color ultrasound was rechecked: there was no obvious abnormality in the morphology and activity of each valve, and CDFI showed: slight regurgitation of the tricuspid valve during systole. Left ventricular diastolic function is impaired. It can be seen that this patent can effectively improve heart valves.

[0070] Case 3

[0071] Jin * Yong, male, 49 years old, corporate executive, has many social engagements and stays up late more often. In May 2018, a physical examination showed cardiac ultrasound: mild mitral valve regurgitation, mitral valve orifice, E<A peak, Ea<Aa peak. Mild tricuspid valve regurgitation. In March 2019, maintenance was started (the product obtained in Example 3, one dose per day), and comprehensive maintenance lasted for 3 months, during which work and life continued as usual. In July 2019, a cardiac ultrasound was repeated, showing mild mitral valve regurgitation, mitral valve orifice, E>A peak, Ea>Aa peak. The tricuspid pulmonary valve has a thin echo and good activity, and color Doppler: no obvious abnormalities were found. By comparison, after three months, the heart valve only had mild mitral valve regurgitation. It can be seen that this patent can effectively improve the heart valve.

[0072] Case 4

[0073] Li * Li, female, 48 years old, business owner, reported that her family has a weak heart, and she has always been afraid of heart problems, so she attaches great importance to health. In April 2019, cardiac color Doppler ultrasound showed: decreased left ventricular diastolic function, and slight regurgitation of the mitral valve and pulmonary valve. After the Spring Festival in 2020, maintenance was started (the product obtained in Example 3, one dose per day). During this period, I was busy with work and took it intermittently, and finally took it for a total of 10 months. Maintenance was stopped before the Spring Festival in 2021. A cardiac color Doppler ultrasound was repeated in May 2022, showing: the echoes of the atrioventricular valves were still thin and there was no difference in opening. CDFI: Mild regurgitation signals were detected at the tricuspid valve orifice, and no obvious abnormal blood flow signals were found in the other valve orifices. By comparison, it can be seen that the mitral valve and pulmonary valve have been repaired, and new tricuspid valve mild regurgitation has appeared. It can be seen that this patent can effectively improve heart valves.

[0074] Case 5

[0075] Lin*, female, 52 years old, a staff member of the procuratorate, has an average work rhythm, exercises and eats regularly, is in good basic physical condition, and pays special attention to health. As age increases, the internal organs have a natural aging state. The cardiac ultrasound of the physical examination in October 2022 showed: mild mitral valve regurgitation and mild tricuspid valve regurgitation. In January 2023, comprehensive maintenance (the product obtained in Example 3, one dose per day) was started, taking into account the maintenance of heart valves. During this period, there were interruptions due to busy work and business trips, which lasted for a total of 15 months. The cardiac ultrasound of the physical examination in September 2024 showed: the valves were not thick, the echo was not significantly enhanced, and the opening and closing activities were free. The blood flow at each valve orifice was normal, and no obvious reflux signals were seen. Because the duration is relatively long, the heart valve repair is particularly perfect. It can be seen that this patent can effectively improve the heart valves.

[0076] Case 6

[0077] Ying * Ying, female, 57 years old, street worker, has a slow work pace, regular daily diet, and likes sports. However, as she ages, her heart feels uncomfortable from time to time. During the physical examination in April 2019, cardiac color ultrasound showed a small amount of reflux signals at the tricuspid valve and mitral valve orifices. Maintenance for 3 months was immediately started (the product obtained in Example 3, one dose per day), during which time work and life continued as usual. In July 2019, the cardiac color ultrasound was rechecked: the mitral valve was not thick, the echo was normal, the opening was not restricted, and CDFI showed no obvious reflux. There was still mild reflux in the tricuspid valve. It can be seen that this patent can effectively improve the heart valve.

[0078] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition having the effect of repairing heart valves, characterized in that: The invention comprises the following components in parts by weight: 18-22 parts of yam, 10-20 parts of prepared rehmannia root, 10-20 parts of raw rehmannia root, 10-20 parts of salvia miltiorrhiza, 10-20 parts of angelica sinensis, 10-20 parts of moutan bark, 10-20 parts of millettia reticulata, 8-12 parts of peach kernel, 8-12 parts of coptis root, 8-12 parts of ophiopogon japonicus, 8-12 parts of codonopsis pilosula, 8-12 parts of polygonatum odoratum and 8-12 parts of arborvitae seed.

2. The method for preparing the Chinese medicine composition according to claim 1, characterized in that: The steps include: (1) Mixing Chinese yam, prepared rehmannia root, raw rehmannia root, salvia miltiorrhiza, angelica sinensis, moutan bark, millettia spatholobi, peach kernel, coptis root, ophiopogon japonicus, codonopsis pilosula, polygonatum odoratum, and cypress seed to obtain material 1; mixing material 1 with water, soaking, decocting, and filtering to obtain a filtrate and a filter residue; (2) mixing the filter residue obtained in step (1) with water and boiling, and filtering to obtain a decoction; (3) Mixing the filtrate obtained in step (1) with the decoction obtained in step (2) to obtain a Chinese medicine composition.

3. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: The mass ratio of the material 1 to water in step (1) is 1:3-4.

4. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: The soaking time in step (1) is 25 to 35 minutes.

5. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: The decocting time in step (1) is 15 to 25 minutes.

6. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: The mass ratio of the filter residue to water in step (2) is 1:2-3.

7. The method for preparing the Chinese medicine composition according to claim 2, characterized in that: The cooking time in step (2) is 15 to 25 minutes.

8. Use of the Chinese medicine composition according to claim 1 or the Chinese medicine composition obtained by the preparation method according to any one of claims 2 to 7 in the preparation of a pharmaceutical preparation having the effect of repairing heart valves.

9. The use according to claim 8, characterized in that: The dosage form of the pharmaceutical preparation is decoction, fluid extract, powder, granule, pill, tablet or capsule.

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