A multi-layer co-extruded cosmetic tube and preparation method thereof

Abstract

The present invention relates to the technical field of plastic co-extruded hose for cosmetic packaging, and discloses a multi-layer co-extruded cosmetic pipe and a preparation method thereof, based on nucleophilic substitution and Biginelli reaction mechanism, using ethyl 4-chloroacetoacetate, 2,4-dihydroxybenzophenone or 2,2',4,4'-tetrahydroxybenzophenone, vanillin and urea as raw materials, synthesizing antioxidants I or II containing ultraviolet absorption groups, preparing functional modified polyethylene based on antioxidant packaging technology; designing an eleven-layer co-extruded film with an asymmetric structure, adopting an eleven-layer co-extrusion blow molding process, preparing a multi-layer co-extruded cosmetic pipe, the raw material of the inner layer of the multi-layer co-extruded cosmetic pipe is functional modified polyethylene. The present invention prevents the active ingredients in cosmetics from oxidizing by antioxidant packaging technology on the one hand when packaging cosmetics, and prevents the active ingredients in cosmetics from oxidizing by absorbing ultraviolet light technology on the other hand.

Description

Technical Field

[0001] The invention relates to the technical field of plastic co-extruded hoses for cosmetic packaging, in particular to a multi-layer co-extruded cosmetic tube and a preparation method thereof. Background Art

[0002] With the rapid development of the cosmetics industry, plastic hoses are favored by many cosmetics manufacturers for their light weight, easy to carry, durable, recyclable, easy to squeeze, good processing performance and printing adaptability. They are widely used in the packaging of cosmetics such as cleansing products (facial cleansers), skin care products (eye creams, moisturizers, nourishing creams, vanishing creams and sunscreens) and beauty and hairdressing products (shampoo, conditioner, lipstick).

[0003] At present, the plastic hoses commonly used in cosmetic packaging mainly include aluminum-plastic composite hoses, all-plastic composite hoses and plastic co-extruded hoses, which can meet various requirements of cosmetic packaging, such as hygiene, barrier properties, etc. Among them, plastic co-extruded hoses use co-extrusion technology to co-extrude raw materials of different properties and types together for one-time molding. Plastic co-extruded hoses are divided into single-layer extrusion hoses and multi-layer co-extruded hoses. The former is mainly used for the packaging of fast-consumption cosmetics (such as hand cream, etc.) with high requirements on appearance and low requirements on actual performance, while the latter is mainly used for the packaging of high-end cosmetics.

[0004] In recent years, consumers' demand for skin care products has continued to grow. In order to meet consumers' demand for higher quality products, active packaging technology has emerged and is widely used in the cosmetics industry, usually including gas-regulated packaging, antibacterial packaging and antioxidant packaging. Among them, antioxidant packaging technology is to add antioxidants to packaging materials to prevent oxidation reactions in cosmetics and delay the expiration of the effective ingredients of cosmetics. Studies have shown that the application of antioxidant packaging in cosmetics has also achieved remarkable results. For example, the antioxidant capacity of cosmetics using antioxidant packaging has been significantly improved, and the preservation performance of the effective ingredients has been improved.

[0005] In addition, ultraviolet rays are a type of electromagnetic radiation that has a great impact on the performance quality of cosmetics. Therefore, anti-ultraviolet packaging has become an important functional requirement for cosmetic packaging. Summary of the invention

[0006] The present invention independently develops a multi-layer co-extruded cosmetic tube product by means of plastic co-extrusion technology and antioxidant packaging technology, which can not only effectively prevent the oxidation reaction of the active ingredients in the cosmetics, but also has excellent light barrier performance.

[0007] A method for preparing a multi-layer co-extruded cosmetic tube comprises the following steps:

[0008] Step 1: Based on nucleophilic substitution and Biginelli reaction mechanism, ethyl 4-chloroacetoacetate, 2,4-dihydroxybenzophenone, vanillin and urea were used as raw materials to synthesize antioxidant I containing ultraviolet absorbing groups;

[0009] Based on nucleophilic substitution and Biginelli reaction mechanism, antioxidant II containing UV absorbing groups was synthesized from ethyl 4-chloroacetoacetate, 2,2',4,4'-tetrahydroxybenzophenone, vanillin and urea.

[0010] Step 2: adding 75-90wt% of low-density polyethylene resin LDPE, 5-15wt% of maleic anhydride grafted polyethylene resin PE-g-MAH and 5-10wt% of antioxidant I or II containing ultraviolet absorption groups into a high-speed mixer and mixing them evenly, and extruding and granulating them through a twin-screw extruder to prepare functional modified polyethylene PE;

[0011] Step 3: Design an eleven-layer co-extruded film with an asymmetric structure, and set the product structure of the eleven-layer co-extruded film, the formula and dosage of each film layer, and adopt an eleven-layer co-extrusion blow molding process to prepare a multi-layer co-extruded cosmetic tube. The raw material of the inner layer of the multi-layer co-extruded cosmetic tube is functional modified polyethylene PE.

[0012] Preferably, the preparation method of the antioxidant I containing ultraviolet absorbing groups is:

[0013] Using a nucleophilic substitution reaction mechanism, a basic catalyst is used to catalyze a nucleophilic substitution reaction between 1 molar equivalent of ethyl 4-chloroacetoacetate and 1.01-1.09 molar equivalent of 2,4-dihydroxybenzophenone to generate a β-ketoester monomer.

[0014] The Biginelli reaction mechanism is utilized to generate an antioxidant I containing an ultraviolet absorbing group by catalyzing a condensation reaction of 1 molar equivalent of β-ketoester monomer, 1.01-1.09 molar equivalent of vanillin and 1.01-1.09 molar equivalent of urea with an acid catalyst.

[0015] Preferably, the preparation method of the antioxidant II containing ultraviolet absorbing groups is:

[0016] Using a nucleophilic substitution reaction mechanism, a basic catalyst is used to catalyze a nucleophilic substitution reaction between 2 molar equivalents of chloro functional groups of ethyl 4-chloroacetoacetate and 1.01-1.09 molar equivalents of 2,2',4,4'-tetrahydroxybenzophenone to generate a di(β-ketoester) monomer;

[0017] The Biginelli reaction mechanism is utilized to generate an antioxidant II containing an ultraviolet absorbing group by condensing 1 molar equivalent of di(β-ketoester) monomer, 2.01-2.09 molar equivalents of vanillin and 2.01-2.09 molar equivalents of urea catalyzed by an acidic catalyst.

[0018] Preferably, the alkaline catalyst is one of sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide.

[0019] Preferably, the acidic catalyst is one of sulfuric acid, hydrochloric acid, nitric acid and phosphoric acid.

[0020] Preferably, the product structure of the eleven-layer co-extruded film with an asymmetric structure, the formula of each film layer and the specific settings of the dosage are:

[0021] First layer: the raw material is low-density polyethylene resin LDPE, the dosage is 5-15 parts by weight;

[0022] The second layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight;

[0023] The third layer: the raw material is high-density polyethylene resin HDPE, the dosage is 3-10 parts by weight;

[0024] The fourth layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight;

[0025] The fifth layer: the raw material is maleic anhydride grafted polyethylene resin PE-g-MAH, the amount is 3-8 parts by weight;

[0026] The sixth layer: the raw material is ethylene-vinyl alcohol copolymer resin EVOH, the amount is 5-15 parts by weight;

[0027] The seventh layer: the raw material is maleic anhydride grafted polyethylene resin PE-g-MAH, the amount is 3-8 parts by weight;

[0028] The eighth layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight;

[0029] Ninth layer: the raw material is high-density polyethylene resin HDPE, the amount is 3-10 parts by weight;

[0030] The tenth layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight;

[0031] The eleventh layer: the raw material is functional modified polyethylene PE, the dosage is 10-30 parts by weight.

[0032] The wall thickness of the multi-layer co-extruded cosmetic tube prepared according to the above method is 200-300 μm.

[0033] The multi-layer co-extruded cosmetic tube prepared according to the above method can prevent the oxidation reaction of the active ingredients in the cosmetics by using the anti-oxidation packaging technology when packaging cosmetics, and can also prevent the oxidation reaction of the active ingredients in the cosmetics by using the ultraviolet absorption technology.

[0034] Beneficial effects: Based on the molecular design method, the present invention utilizes the nucleophilic substitution reaction and the Biginelli reaction mechanism to synthesize two antioxidants containing ultraviolet absorption groups, and adds the antioxidants containing ultraviolet absorption groups to polyethylene packaging materials through antioxidant packaging technology to prepare functional modified polyethylene PE;

[0035] Functionally modified polyethylene PE is used as the raw material for the inner layer of the tube that is in direct contact with cosmetics, and a multi-layer co-extruded cosmetic tube product is prepared through multi-layer co-extrusion blow molding technology;

[0036] The experimental results show that the multi-layer co-extruded cosmetic tube product developed by the present invention based on the antioxidant packaging technology has achieved significant improved beneficial technical effects in terms of antioxidant and anti-ultraviolet properties. It can be used to package cosmetics and can achieve the beneficial technical effect of preventing oxidation reactions of active ingredients in cosmetics. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 is the chemical structural formula of antioxidant I containing an ultraviolet absorbing group;

[0038] Figure 2 is the chemical structural formula of antioxidant II containing ultraviolet absorbing groups;

[0039] Figure 3 These are the performance test results of multi-layer co-extruded cosmetic tubes. DETAILED DESCRIPTION Embodiment 1:

[0040] A multi-layer co-extruded cosmetic tube, the product structure and the raw material formula and dosage of each layer are shown in Table 1;

[0041] Table 1 Experimental formula of multi-layer co-extruded cosmetic tubes

[0042]

[0043] The formula of the functional modified polyethylene PE is: 80wt% low-density polyethylene resin LDPE, 12wt% maleic anhydride grafted polyethylene resin PE-g-MAH and 8wt% antioxidant containing ultraviolet absorbing groups;

[0044] The antioxidant containing an ultraviolet absorbing group is an antioxidant I containing an ultraviolet absorbing group or an antioxidant II containing an ultraviolet absorbing group;

[0045] The chemical structure of antioxidant I containing UV absorbing groups is as follows Figure 1 As shown, a preparation method of the antioxidant I containing a UV absorbing group is described in Experimental Example 1; the chemical structure of the antioxidant II containing a UV absorbing group is as shown Figure 2 As shown, a preparation method of antioxidant II containing ultraviolet absorbing groups is described in Experimental Example 2. Embodiment 2:

[0046] A preparation process of a multi-layer co-extruded cosmetic tube comprises the following specific steps:

[0047] Step 1, preparing functional modified polyethylene PE: placing low-density polyethylene resin LDPE, maleic anhydride grafted polyethylene resin PE-g-MAH and an antioxidant containing a UV absorbing group in a vacuum drying oven at 80°C for 12 hours, then adding them into a high-speed mixer according to the formula of the functional modified polyethylene PE and mixing them evenly, extruding and granulating them through a twin-screw extruder, and vacuum drying them at 80°C for 6 hours to prepare the functional modified polyethylene PE;

[0048] Among them, the process parameters of the twin-screw extruder are set as follows: the temperatures of zones 1-6 are 165°C, 170°C, 175°C, 180°C, 180°C, and 185°C, respectively, and the speed is 400r / min;

[0049] Step 3, preparing a multi-layer co-extruded cosmetic tube: according to the formula of the multi-layer co-extruded cosmetic tube, ingredients are prepared, and the raw materials of each layer are respectively put into the hoppers of eleven screw extruders of the eleven-layer co-extrusion film blow molding unit, and the molten resin is merged at the head of the die through a diverter, and is extruded and blow-molded through a die head, and molded to prepare a multi-layer co-extruded cosmetic tube with a tube wall thickness of 250 μm;

[0050] Among them, the process parameters of the screw extruder corresponding to the first, second, third, fourth, eighth, ninth, tenth and eleventh layers are set as follows: the temperature of zones 1-3 is 130°C, 150°C and 180°C respectively, the flow channel temperature is 175°C, and the speed is 40r / min;

[0051] The process parameters of the screw extruder corresponding to the fifth and seventh layers were set as follows: the temperatures of zones 1-3 were 120°C, 150°C, and 170°C, respectively, the flow channel temperature was 160°C, and the rotation speed was 20 r / min;

[0052] The process parameters of the screw extruder corresponding to the sixth layer were set as follows: the temperatures of zones 1-3 were 180°C, 200°C, and 210°C, respectively, the flow channel temperature was 205°C, and the rotation speed was 60 r / min;

[0053] When the antioxidant containing a UV absorbing group is antioxidant I containing a UV absorbing group, the prepared product is recorded as multi-layer co-extruded cosmetic tube I;

[0054] When the antioxidant containing ultraviolet absorbing groups is antioxidant II containing ultraviolet absorbing groups, the prepared product is recorded as multi-layer co-extruded cosmetic tube II.

[0055] Comparative Example:

[0056] Preparation of conventional pipes: The difference between its preparation process and the preparation process of multi-layer co-extruded cosmetic pipe I is that low-density polyethylene resin LDPE is used to replace functional modified polyethylene PE.

[0057] Performance Testing:

[0058] 1. Antioxidant performance test: The antioxidant capacity of the sample was characterized by the DPPH free radical scavenging rate. The specific test steps were as follows: 80 mm × 40 mm sample was placed in a brown sample bottle containing 40 mL of methanol and soaked for 7 days to obtain the sample soaking solution. 3 mL of the sample soaking solution and 1 mL of 10 3 mol / L DPPH methanol solution was mixed evenly, kept away from light for 24 hours, and the absorbance of the reaction solution system at 517nm was measured by SP-1105 ultraviolet spectrophotometer. The absorbance of DPPH free radical methanol solution was measured by the same method, and the DPPH free radical scavenging rate was calculated. The specific method is as follows:

[0059] DPPH free radical scavenging rate (%) = (absorbance of DPPH methanol solution - absorbance of the mixed system of sample immersion solution and DPPH methanol solution) / absorbance of DPPH methanol solution;

[0060] 2. Anti-ultraviolet performance test: Lambda 950 UV-visible spectrophotometer was used to test the transmittance of the sample in accordance with GB / T 2410-2008 standard. The test wavelength range was 250-800nm, and the transmittance of the sample at 380nm was recorded;

[0061] 3. Barrier performance test:

[0062] Oxygen barrier performance test: Use Y110 oxygen permeability tester to test the oxygen permeability of samples according to GB / T 1038-2022 standard;

[0063] Water vapor barrier performance test: Use TC-03 water vapor transmission meter to test the water vapor transmission rate of the sample according to GB / T 1037-2021 standard;

[0064] 4. Mechanical properties test: Use Instron 5565 universal tensile testing machine to test the tensile strength of samples according to GB / T 1040.1-2018 standard (sampling along the film blowing direction), with a tensile rate of 5mm / min;

[0065] The above experimental results are shown in Table 2 and Figure 3 .

[0066] Table 2 Performance test results of multi-layer co-extruded cosmetic tubes

[0067]

[0068] By comprehensively analyzing the above experimental results, the following conclusions can be drawn:

[0069] (1) The present invention utilizes an antioxidant containing ultraviolet absorbing groups to modify polyethylene resin, and the multi-layer co-extruded cosmetic tube product prepared thereby has achieved beneficial technical effects of significantly improving the antioxidant and anti-ultraviolet properties;

[0070] Among them, the antioxidant II containing ultraviolet absorption groups has a better effect on improving the antioxidant and anti-ultraviolet properties of multi-layer co-extruded cosmetic tube products than the antioxidant I containing ultraviolet absorption groups;

[0071] (2) The multi-layer co-extruded cosmetic tube product prepared by the present invention has excellent barrier properties and mechanical properties and has practical application value.

[0072] Experimental Example 1:

[0073] The preparation steps of antioxidant I containing ultraviolet absorbing groups are as follows:

[0074] The first step: using the nucleophilic substitution reaction mechanism, a basic catalyst is used to catalyze the nucleophilic substitution reaction between 1 molar equivalent of ethyl 4-chloroacetoacetate and 1.08 molar equivalent of 2,4-dihydroxybenzophenone to generate a β-ketoester monomer;

[0075] The alkaline catalyst is one of sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide; sodium hydroxide is used in this experimental example;

[0076] Step 2: Using the Biginelli reaction mechanism, 1 molar equivalent of β-ketoester monomer, 1.02 molar equivalent of vanillin and 1.05 molar equivalent of urea are condensed by an acidic catalyst to generate an antioxidant I containing a UV absorbing group, whose chemical structure is as follows: Figure 1 As shown;

[0077] The acid catalyst is one of sulfuric acid, hydrochloric acid, nitric acid and phosphoric acid; hydrochloric acid is used in this experiment;

[0078] The specific experimental steps for preparing antioxidant I containing UV absorbing groups are as follows:

[0079] 2.2 g of 2,4-dihydroxybenzophenone, 10 mL of 1 mol / L sodium hydroxide aqueous solution and 30 mL of acetone were added to a three-necked flask, stirred at room temperature until completely dissolved, and added dropwise to 10 mL of ethyl 4-chloroacetoacetate solution (prepared with 1.6 g of ethyl 4-chloroacetoacetate and 10 mL of acetone) under nitrogen protection, heated to 50°C, refluxed and stirred for reaction for 8 h, cooled to room temperature, and selectively evaporated to remove the solvent, washed with deionized water and ethanol in turn, and dried in vacuo to obtain a β-ketoester monomer;

[0080] 1.7 g of β-ketoester monomer, 0.8 g of vanillin, 0.3 g of urea and 30 mL of ethanol were added to a three-necked flask. Under nitrogen protection and mechanical stirring, 5 drops of concentrated hydrochloric acid were slowly added to the three-necked flask. The temperature was raised to 85°C and refluxed for 4 h. The mixture was cooled to room temperature, the solvent was removed by rotary evaporation, and vacuum dried to obtain an antioxidant I containing a UV absorbing group.

[0081] The nuclear magnetic resonance hydrogen spectrum of antioxidant I containing ultraviolet absorbing groups is characterized as follows: 1 H NMR (CDCl3, 400MHz) δ: 1.20-1.24 (t, 3H), 3.80 (s, 3H), 4.07-4.13 (m, 2H), 5.06 (s, 2H), 5.31 (s, 1H), 6.54-7.74 (m, 11H, Ar-H).

[0082] Experimental Example 2:

[0083] The preparation steps of antioxidant II containing ultraviolet absorbing groups are as follows:

[0084] The first step: using the nucleophilic substitution reaction mechanism, a basic catalyst is used to catalyze the nucleophilic substitution reaction of 2 molar equivalents of chloro functional groups of ethyl 4-chloroacetoacetate and 1.08 molar equivalents of 2,2',4,4'-tetrahydroxybenzophenone to generate a di(β-ketoester) monomer;

[0085] The alkaline catalyst is one of sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide; sodium hydroxide is used in this experimental example;

[0086] Step 2: Using the Biginelli reaction mechanism, an acidic catalyst is used to catalyze the condensation reaction of 1 molar equivalent of di(β-ketoester) monomer, 2.03 molar equivalents of vanillin and 2.05 molar equivalents of urea to generate an antioxidant II containing an ultraviolet absorbing group, whose chemical structure is as follows: Figure 2 As shown;

[0087] The acid catalyst is one of sulfuric acid, hydrochloric acid, nitric acid and phosphoric acid; hydrochloric acid is used in this experiment;

[0088] The specific experimental steps for preparing antioxidant II containing ultraviolet absorbing groups are as follows:

[0089] Prepare di(β-ketoester) monomer, the preparation steps of which refer to the preparation experiment of β-ketoester monomer, and the only difference is that 3.2g of ethyl 4-chloroacetoacetate is used to replace 1.6g of ethyl 4-chloroacetoacetate;

[0090] The preparation steps of antioxidant II containing ultraviolet absorbing groups are referred to the preparation experiment of antioxidant I containing ultraviolet absorbing groups, and the difference is only that 1.3g of di(β-ketoester) monomer is used to replace 1.7g of β-ketoester monomer;

[0091] The nuclear magnetic resonance hydrogen spectrum of antioxidant II containing ultraviolet absorbing groups is characterized as follows: 1 H NMR (CDCl3, 400MHz) δ: 1.27-1.31 (t, 6H), 3.80 (s, 6H), 4.14-4.20 (m, 4H), 5.03 (s, 4H), 5.30 (s, 2H), 6.52-7.48 (m, 12H, Ar-H).

Claims

1. A method for preparing a multi-layer co-extruded cosmetic tube, characterized in that: The steps include: Step 1: Based on nucleophilic substitution and Biginelli reaction mechanism, ethyl 4-chloroacetoacetate, 2,4-dihydroxybenzophenone, vanillin and urea were used as raw materials to synthesize antioxidant I containing ultraviolet absorbing groups; Based on nucleophilic substitution and Biginelli reaction mechanism, antioxidant II containing UV absorbing groups was synthesized from ethyl 4-chloroacetoacetate, 2,2',4,4'-tetrahydroxybenzophenone, vanillin and urea. Step 2: adding 75-90wt% of low-density polyethylene resin LDPE, 5-15wt% of maleic anhydride grafted polyethylene resin PE-g-MAH and 5-10wt% of antioxidant I or II containing ultraviolet absorption groups into a high-speed mixer and mixing them evenly, and extruding and granulating them through a twin-screw extruder to prepare functional modified polyethylene PE; Step 3: Design an eleven-layer co-extruded film with an asymmetric structure, and set the product structure of the eleven-layer co-extruded film, the formula and dosage of each film layer, and adopt an eleven-layer co-extrusion blow molding process to prepare a multi-layer co-extruded cosmetic tube. The raw material of the inner layer of the multi-layer co-extruded cosmetic tube is functional modified polyethylene PE.

2. The method for preparing a multi-layer co-extruded cosmetic tube according to claim 1, characterized in that: The chemical structural formula of the antioxidant I containing the ultraviolet absorbing group is: 。 3. The method for preparing a multi-layer co-extruded cosmetic tube according to claim 2, characterized in that: The preparation method of the antioxidant I containing ultraviolet absorbing groups is as follows: Using a nucleophilic substitution reaction mechanism, a basic catalyst is used to catalyze a nucleophilic substitution reaction between 1 molar equivalent of ethyl 4-chloroacetoacetate and 1.01-1.09 molar equivalent of 2,4-dihydroxybenzophenone to generate a β-ketoester monomer. The Biginelli reaction mechanism is utilized to generate an antioxidant I containing an ultraviolet absorbing group by catalyzing a condensation reaction of 1 molar equivalent of β-ketoester monomer, 1.01-1.09 molar equivalent of vanillin and 1.01-1.09 molar equivalent of urea with an acid catalyst.

4. The method for preparing a multi-layer co-extruded cosmetic tube according to claim 1, characterized in that: The chemical structural formula of the antioxidant II containing the ultraviolet absorbing group is: 。 5. The method for preparing a multi-layer co-extruded cosmetic tube according to claim 4, characterized in that: The preparation method of the antioxidant II containing ultraviolet absorbing groups is as follows: Using a nucleophilic substitution reaction mechanism, a basic catalyst is used to catalyze a nucleophilic substitution reaction between 2 molar equivalents of chloro functional groups of ethyl 4-chloroacetoacetate and 1.01-1.09 molar equivalents of 2,2',4,4'-tetrahydroxybenzophenone to generate a di(β-ketoester) monomer; The Biginelli reaction mechanism is utilized to generate an antioxidant II containing an ultraviolet absorbing group by condensing 1 molar equivalent of di(β-ketoester) monomer, 2.01-2.09 molar equivalents of vanillin and 2.01-2.09 molar equivalents of urea catalyzed by an acidic catalyst.

6. The method for preparing a multi-layer co-extruded cosmetic tube according to claim 3 or 5, characterized in that: The alkaline catalyst is one of sodium carbonate, potassium carbonate, sodium hydroxide and potassium hydroxide.

7. The method for preparing a multi-layer co-extruded cosmetic tube according to claim 3 or 5, characterized in that: The acidic catalyst is one of sulfuric acid, hydrochloric acid, nitric acid and phosphoric acid.

8. The method for preparing a multi-layer co-extruded cosmetic tube according to claim 1, characterized in that: The product structure of the eleven-layer co-extruded film with an asymmetric structure, the formula and dosage of each film layer are specifically set as follows: First layer: the raw material is low-density polyethylene resin LDPE, the dosage is 5-15 parts by weight; The second layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight; The third layer: the raw material is high-density polyethylene resin HDPE, the dosage is 3-10 parts by weight; The fourth layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight; The fifth layer: the raw material is maleic anhydride grafted polyethylene resin PE-g-MAH, the amount is 3-8 parts by weight; The sixth layer: the raw material is ethylene-vinyl alcohol copolymer resin EVOH, the amount is 5-15 parts by weight; The seventh layer: the raw material is maleic anhydride grafted polyethylene resin PE-g-MAH, the amount is 3-8 parts by weight; The eighth layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight; Ninth layer: the raw material is high-density polyethylene resin HDPE, the amount is 3-10 parts by weight; The tenth layer: the raw material is low-density polyethylene resin LDPE, the amount is 5-15 parts by weight; The eleventh layer: the raw material is functional modified polyethylene PE, the dosage is 10-30 parts by weight.

9. A multi-layer co-extruded cosmetic tube prepared by the method according to any one of claims 1 to 5, characterized in that: The wall thickness of the multi-layer co-extruded cosmetic tube is 200-300 μm.

10. Application of a multi-layer co-extruded cosmetic tube prepared by the method according to any one of claims 1 to 5, characterized in that: When packaging cosmetics, the cosmetic tube prevents the active ingredients in the cosmetics from undergoing oxidation reactions by using anti-oxidation packaging technology, and prevents the active ingredients in the cosmetics from undergoing oxidation reactions by using ultraviolet absorption technology.

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