Tightening thixotropic gel with slow release effect and preparation method thereof

Abstract

The invention relates to tightening thixotropic gel with a slow release effect and a preparation method thereof, and belongs to the technical field of gel. On the basis of the deionized water, the thickening component, the chamomilla recutita flower extract, the lactic acid, the allantoin, the tocopheryl nicotinate, the polysorbate-20 and the hydrolyzed actin are combined, and through the synergistic effect of the components, excellent adhesion and permeability are shown on vaginal mucosa. Due to the thixotropy of the gel, the viscosity is reduced when the gel is used, the gel is easy to smear, and then the original viscosity is recovered to form a stable layer. The characteristic ensures controllable and continuous release of active ingredients, promotes contraction and recombination of collagenous fibers and elastic fibers, enhances compactness and lubricity of private parts, is suitable for improving the problems of dryness and looseness, and helps to keep health and comfort.

Description

Technical Field

[0001] The invention belongs to the technical field of gel, and relates to a compact thixotropic gel with a sustained-release effect and a preparation method thereof. Background Art

[0002] Vaginal relaxation is a problem that many women may face after childbirth, aging, or hormonal changes. This condition not only affects women's physical health, but can also have a negative impact on their psychological and emotional state. Vaginal relaxation may lead to a decline in the quality of sexual life and affect the harmony of a partner's relationship. In addition, vaginal relaxation may also lead to problems such as urinary incontinence, affecting the convenience and comfort of daily life. These problems not only plague women's physical health, but may also cause a decline in self-confidence and psychological stress. Therefore, finding effective solutions to improve or reverse the effects of vaginal relaxation is crucial to improving women's quality of life and well-being.

[0003] In this context, gynecological gel, as a non-invasive, easy-to-use care product, has gradually attracted attention. The main function of gynecological gel is to improve vaginal relaxation by enhancing the elasticity and firmness of the vaginal mucosa through local application. Its formula usually contains a variety of active ingredients, such as natural plant extracts, moisturizers and thickeners, which work synergistically to promote the regeneration and repair of vaginal tissue. In addition, gynecological gel can also regulate the pH value of the vagina, maintain a healthy microecological environment, and prevent bacterial and fungal infections. These functions not only help to improve physiological comfort, but also improve the quality of sexual life and increase women's self-confidence and life satisfaction.

[0004] Although gynecological gels have gained a certain degree of recognition in the market, existing products still have some defects and technical deficiencies. First, the ingredients of many products are complex, which may cause allergic reactions or irritation, especially for women with sensitive skin. In addition, the texture of some gels is not stable enough, and stratification or deterioration may occur during storage, affecting their use effect. Furthermore, existing gel products may not be efficient enough in the release and absorption of active ingredients, resulting in unclear effects or short duration. Finally, some products lack customized solutions for different individual needs and cannot meet diverse user needs. Therefore, the present invention prepares a compact thixotropic gel with sustained release effect by improving the thickener formula and combining the sustained release of active ingredients. Summary of the invention

[0005] The present invention relates to a tightening thixotropic gel with a sustained-release effect and a preparation method thereof, and belongs to the technical field of gel. The present invention is based on deionized water, combined with thickening ingredients, chamomile extract, lactic acid, allantoin, tocopherol nicotinate, polysorbate-20 and hydrolyzed actin, and exhibits excellent adhesion and permeability on the vaginal mucosa through the synergistic effect of the ingredients. During the preparation process, water and thickening ingredients are mixed to form a basic gel, and then other ingredients are gradually added to ensure uniform distribution and stability, adjust the pH value and enhance comfort. The thixotropy of the gel reduces its viscosity during use, making it easy to apply, and then restores its original viscosity to form a stable layer. This property ensures the controllable and sustained release of active ingredients, promotes the contraction and reorganization of collagen fibers and elastic fibers, enhances the firmness and lubricity of private parts, is suitable for improving dryness and relaxation problems, and helps maintain health and comfort.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] A compact thixotropic gel with a sustained-release effect comprises the following raw materials in parts by weight: 60-80 parts by weight of deionized water, 2-5 parts by weight of a thickening component, 1-3 parts by weight of a chamomile flower extract, 0.5-1 parts by weight of a preservative, 0.5-1 parts by weight of lactic acid, 0.1-0.5 parts by weight of allantoin, 1-3 parts by weight of a tocopherol nicotinate stock solution, 0.5-2 parts by weight of polysorbate-20 and 1-2 parts by weight of a hydrolyzed actin stock solution.

[0008] As a preferred technical solution of the present invention, the thickening component provides thixotropy and stability of the gel, and the raw materials include: aloe vera leaf juice, sodium alginate, mushroom extract, red ganoderma extract, shiitake mushroom extract, and inonotus obliquus extract, and the mass ratio of the aloe vera leaf juice, sodium alginate, mushroom extract, red ganoderma extract, shiitake mushroom extract, and inonotus obliquus extract is 6-10:2-4:1-3:1-3:1-3:1-3:1-3.

[0009] As a preferred technical solution of the present invention, the preservative ingredients are phenoxyethanol, caprylyl glycol, and benzoic acid, and the mass ratio of phenoxyethanol, caprylyl glycol, and benzoic acid is 0.8-1:0.4-0.6:0.2-0.3.

[0010] As a preferred technical solution of the present invention, the tocopherol nicotinate stock solution provides antioxidant and moisturizing effects, and its ingredients are tocopherol nicotinate and caprylic / capric triglyceride. The mass ratio of tocopherol nicotinate and caprylic / capric triglyceride is 1:3-7.

[0011] As a preferred technical solution of the present invention, the hydrolyzed actin stock solution provides moisturizing and enhances the skin barrier function, and its ingredients include deionized water, 1.2-hexanediol, and hydrolyzed actin. The mass ratio of the deionized water, 1.2-hexanediol, and hydrolyzed actin is 50-80:5-20:0.1-5.

[0012] As a preferred technical solution of the present invention, the chamomile extract is used for soothing and anti-inflammatory; the lactic acid not only adjusts the pH value, but also has moisturizing and exfoliating effects; the addition of allantoin has the effect of promoting healing and soothing the skin; the polysorbate-20 acts as an emulsifier to help mix the water and oil components.

[0013] Furthermore, the method for preparing the compact thixotropic gel with sustained release effect comprises the following steps:

[0014] (1) Heat deionized water to 85-90°C, keep the temperature at 80±5°C, add thickening ingredients, mix and disperse homogeneously, and stir until completely dissolved;

[0015] (2) Cooling to 45° C., adding chamomile extract and preservatives while stirring, and mixing evenly;

[0016] (3) Add allantoin and hydrolyzed actin stock solution and stir evenly;

[0017] (4) Add polysorbate 20 and stir evenly;

[0018] (5) After uniformly mixing the tocopherol nicotinate stock solution, add it into the material and stir evenly;

[0019] (6) Add lactic acid to adjust the pH value.

[0020] As a preferred technical solution of the present invention, the pH value in step (6) is 3.8-5.8.

[0021] Beneficial effects of the present invention:

[0022] (1) The present invention is based on the principles of vaginal mucosal adhesion and mucosal permeability to prepare a thixotropic gel with the same pH value and osmotic pressure as the vagina. When used on the vaginal mucosa, the internal distribution of entanglements in the shear direction changes, the viscosity decreases, and after being applied to the vaginal mucosa, the initial rheological properties will be immediately restored to respond to physiological stimulation, so that a viscous gel is formed in the vaginal cavity, giving the active controllable and sustainable release characteristics.

[0023] (2) The thixotropic gel of the present invention achieves the effects of sustained release, controlled release, and sufficient absorption, and can shrink and reorganize damaged collagen fibers, elastic fibers, etc., thereby thickening and tightening the private wall, and then the private wall's firmness, sensitivity, and lubrication are significantly enhanced, and the private wall is as tight as before. It is used for women's dry vaginal relaxation and daily care, and has the effects of firming, maintaining, and lubricating, and maintains a normal pH value. DETAILED DESCRIPTION

[0024] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0025] In the following examples and comparative examples, the thickening ingredients (aloe barbadensis leaf juice, sodium alginate, Agaricus oleraceus extract, Ganoderma lucidum extract, Lentinus edodes extract, and Inonotus obliquus extract) were purchased from L COSMETIX LIMITED (the proportion of each component can be adjusted); chamomile flower extract was purchased from L COSMETIX LIMITED; allantoin was purchased from Ashland (China) Investment Co., Ltd.; polysorbate 20 was purchased from Guangdong Runhua Chemical Co., Ltd.; and hydrolyzed actin stock solution was purchased from Gansu Boshikang Chemical Technology Co., Ltd.

[0026] Example 1

[0027] A tightening thixotropic gel with a sustained-release effect comprises the following raw materials in parts by weight: 70 parts by weight of deionized water, 3 parts by weight of a thickening component, 2 parts by weight of a chamomile flower extract, 0.8 parts by weight of a preservative, 0.8 parts by weight of lactic acid, 0.3 parts by weight of allantoin, 2 parts by weight of a tocopherol nicotinate stock solution, 1 part by weight of polysorbate-20 and 1.5 parts by weight of a hydrolyzed actin stock solution.

[0028] The thickening ingredient provides thixotropy and stability of the gel. The raw materials include: aloe barbadensis leaf juice, sodium alginate, mushroom extract, red ginseng extract, shiitake mushroom extract, and inonotus obliquus extract. The mass ratio of the aloe barbadensis leaf juice, sodium alginate, mushroom extract, red ginseng extract, shiitake mushroom extract, and inonotus obliquus extract is 8:3:2:2:2:2.

[0029] The preservative additives are phenoxyethanol, caprylyl glycol, and benzoic acid, and the mass ratio of phenoxyethanol, caprylyl glycol, and benzoic acid is 1:0.5:0.2.

[0030] The tocopherol nicotinate stock solution provides antioxidant and moisturizing effects. The raw materials are tocopherol nicotinate and caprylic triglyceride. The mass ratio of the tocopherol nicotinate to caprylic triglyceride is 1:5.

[0031] The hydrolyzed actin stock solution provides moisturizing and enhances the skin barrier function, and its ingredients include deionized water, 1.2-hexanediol, and hydrolyzed actin, and the mass ratio of the deionized water, 1.2-hexanediol, and hydrolyzed actin is 65:15:3.

[0032] The chamomile flower extract is used for soothing and anti-inflammatory; the lactic acid not only adjusts the pH value, but also has moisturizing and exfoliating effects; the addition of allantoin has the effect of promoting healing and soothing the skin; the polysorbate-20 acts as an emulsifier to help mix water and oil components.

[0033] The method for preparing the compact thixotropic gel with sustained-release effect comprises the following steps:

[0034] (1) Heat deionized water to 85°C, keep the temperature at 80°C, add thickening ingredients, mix and disperse homogeneously, and stir until completely dissolved;

[0035] (2) Cooling to 45° C., adding chamomile extract and preservatives while stirring, and mixing evenly;

[0036] (3) Add allantoin and hydrolyzed actin stock solution and stir evenly;

[0037] (4) Add polysorbate 20 and stir evenly;

[0038] (5) After uniformly mixing the tocopherol nicotinate stock solution, add it into the material and stir evenly;

[0039] (6) Add lactic acid to adjust the pH value.

[0040] The pH value of step (6) is 4.2.

[0041] Example 2

[0042] A tightening thixotropic gel with a sustained-release effect comprises the following raw materials in parts by weight: 80 parts by weight of deionized water, 5 parts by weight of a thickening component, 3 parts by weight of a chamomile flower extract, 0.5 parts by weight of a preservative, 0.8 parts by weight of lactic acid, 0.2 parts by weight of allantoin, 1 part by weight of a tocopherol nicotinate stock solution, 1 part by weight of polysorbate-20 and 1 part by weight of a hydrolyzed actin stock solution.

[0043] The thickening component provides thixotropy and stability of the gel. The raw materials include: aloe barbadensis leaf juice, sodium alginate, mushroom extract, red ginseng extract, shiitake mushroom extract, and inonotus obliquus extract. The mass ratio of the aloe barbadensis leaf juice, sodium alginate, mushroom extract, red ginseng extract, shiitake mushroom extract, and inonotus obliquus extract is 10:3:1:1:1.

[0044] The preservative ingredients are phenoxyethanol, caprylyl glycol, and benzoic acid, and the mass ratio of phenoxyethanol, caprylyl glycol, and benzoic acid is 1:0.5:0.3.

[0045] The tocopherol nicotinate stock solution provides antioxidant and moisturizing effects. The raw materials are tocopherol nicotinate and capric triglyceride. The mass ratio of the tocopherol nicotinate to capric triglyceride is 1:3.

[0046] The hydrolyzed actin stock solution provides moisturizing and enhances the skin barrier function, and its ingredients include deionized water, 1.2-hexanediol, and hydrolyzed actin, and the mass ratio of the deionized water, 1.2-hexanediol, and hydrolyzed actin is 65:15:3.

[0047] The chamomile flower extract is used for soothing and anti-inflammatory; the lactic acid not only adjusts the pH value, but also has moisturizing and exfoliating effects; the addition of allantoin has the effect of promoting healing and soothing the skin; the polysorbate-20 acts as an emulsifier to help mix water and oil components.

[0048] The method for preparing the compact thixotropic gel with sustained-release effect comprises the following steps:

[0049] (1) Heat deionized water to 90°C, keep the temperature at 85°C, add thickening ingredients, mix and disperse homogeneously, and stir until completely dissolved;

[0050] (2) Cooling to 45° C., adding chamomile extract and preservatives while stirring, and mixing evenly;

[0051] (3) Add allantoin and hydrolyzed actin stock solution and stir evenly;

[0052] (4) Add polysorbate 20 and stir evenly;

[0053] (5) After uniformly mixing the tocopherol nicotinate stock solution, add it into the material and stir evenly;

[0054] (6) Add lactic acid to adjust the pH value.

[0055] The pH value of step (6) is 4.0.

[0056] Comparative Example 1

[0057] On the basis of Example 1, aloe barbadensis leaf juice was not added, and the mass ratio of sodium alginate, Agaricus oleraceus extract, Ganoderma lucidum extract, Lentinus edodes extract and Inonotus obliquus extract in the thickening ingredients was 11:2:2:2:2, and the rest was consistent with Example 1.

[0058] Comparative Example 2

[0059] On the basis of Example 1, sodium alginate was not added, and the mass ratio of aloe vera leaf juice, Agaricus oleraceus extract, Ganoderma lucidum extract, Lentinus edodes extract and Inonotus obliquus extract in the thickening ingredients was 8:5:2:2:2, and the rest was consistent with Example 1.

[0060] Comparative Example 3

[0061] On the basis of Example 1, no Agaricus oleifera extract was added, and the mass ratio of aloe vera leaf juice, sodium alginate, Ganoderma lucidum extract, Lentinus edodes extract, and Inonotus obliquus extract in the thickening ingredients was 8:3:4:2:2, and the rest was consistent with Example 1.

[0062] Comparative Example 4

[0063] On the basis of Example 1, no Ganoderma lucidum extract was added, and the mass ratio of aloe vera leaf juice, sodium alginate, Agaricus oleraceus extract, Lentinus edodes extract, and Inonotus obliquus extract in the thickening ingredients was 8:3:2:4:2, and the rest was consistent with Example 1.

[0064] Comparative Example 5

[0065] On the basis of Example 1, no shiitake mushroom extract was added, and the mass ratio of aloe vera leaf juice, sodium alginate, Agaricus oleraceus extract, Ganoderma lucidum extract and Inonotus obliquus extract in the thickening ingredients was 8:3:2:2:4, and the rest was consistent with Example 1.

[0066] Comparative Example 6

[0067] No Inonotus obliquus extract was added, and the mass ratio of aloe vera leaf juice, sodium alginate, Agaricus oleifera extract, Ganoderma lucidum extract, and Lentinus edodes extract in the thickening component was 10:3:2:2:2, and the rest was consistent with Example 1.

[0068] Comparative Example 7

[0069] On the basis of Example 1, no chamomile extract was added, the added amount of allantoin was changed to 2.3 parts by weight, and the rest was consistent with Example 1.

[0070] Comparative Example 8

[0071] On the basis of Example 1, no allantoin was added, the added amount of tocopherol nicotinate stock solution was changed to 2.3 parts by weight, and the rest was consistent with Example 1.

[0072] Comparative Example 9

[0073] On the basis of Example 1, no tocopherol nicotinate stock solution was added, the amount of hydrolyzed actin stock solution added was changed to 3.5 parts by weight, and the rest was the same as Example 1.

[0074] Comparative Example 10

[0075] On the basis of Example 1, no hydrolyzed actin stock solution was added, the added amount of chamomile flower extract was changed to 3.5 parts by weight, and the rest was consistent with Example 1.

[0076] Performance Test:

[0077] 1. Osmotic pressure test: measured using a fully automatic freezing point osmometer from Yida Medical University. For gynecological gels, the ideal osmotic pressure should be as close as possible to that of human body fluids to avoid irritation or discomfort to the vaginal mucosa, and help reduce cell dehydration or edema caused by osmotic pressure differences, thereby improving product safety and user comfort. Usually, the osmotic pressure of human body fluids does not exceed 310mOsm / kg. The test results are shown in Table 1.

[0078] Table 1 Osmotic pressure test results of Examples 1-2 and Comparative Examples 1-6

[0079] Osmotic pressure (mOsm / kg) Example 1 117 Example 2 123 Comparative Example 1 119 Comparative Example 2 120 Comparative Example 3 122 Comparative Example 4 118 Comparative Example 5 121 Comparative Example 6 119

[0080] 2. Tightening vagina test:

[0081] 120 married women aged 25-50 with vaginal relaxation were randomly divided into 12 groups, with 10 people in each group. The gels of Examples 1-2 and Comparative Examples 1-10 were used on the patients in Groups 1-12, once every two days, one 15 mL gel each time, for 30, 60 and 90 days, and the symptoms and signs of the patients after using the products were recorded.

[0082] Effective judgment criteria: The effective criteria are that the transverse diameter and volume of vaginal relaxation have improved and the patients are satisfied; the ineffective criteria are that the transverse diameter and volume of vagina have not changed and the patients are dissatisfied. The results are shown in Table 2.

[0083] Table 2 Vagina tightening test results of Examples 1-2 and Comparative Examples 1-12

[0084] Group 30 days effective 60 days effective 90 days effective Example 1 90％ 100％ 100％ Example 2 90％ 90％ 100％ Comparative Example 1 60％ 70％ 80％ Comparative Example 2 60％ 60％ 70％ Comparative Example 3 70％ 70％ 80％ Comparative Example 4 60％ 70％ 70％ Comparative Example 5 70％ 70％ 80％ Comparative Example 6 60％ 70％ 70％ Comparative Example 7 50％ 70％ 70％ Comparative Example 8 60％ 60％ 70％ Comparative Example 9 60％ 70％ 70％ Comparative Example 10 50％ 60％ 60％

[0085] As shown in the test results of Table 1, the present invention replaces the traditional thickener carbomer with a thickening component of natural ingredients, and the viscosity of the prepared gel is reduced, which is gentler on the skin and suitable for users with sensitive skin; the thixotropic gel prepared by aloe vera leaf juice, sodium alginate, mushroom extract, red ganoderma extract, shiitake mushroom extract, and birch inonotus extract has an osmotic pressure similar to that of the vagina, and the internal distribution of entanglement in the shear direction changes when used on the vaginal mucosa, and after being applied to the vaginal mucosa, the initial rheological properties will be immediately restored to respond to physiological stimulation, so that a viscous gel is formed in the vaginal cavity, giving active controllable and sustainable release characteristics.

[0086] It can be seen from the test results in Table 2 that the thixotropic gel of the present invention can shrink and reorganize damaged collagen fibers, elastic fibers, etc., thereby thickening and tightening the private wall through the compound of thickening components, chamomile extract, allantoin, tocopherol nicotinate and hydrolyzed actin components.

[0087] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any indirect modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A compact thixotropic gel with sustained release effect, characterized in that: The tightening thixotropic gel comprises the following raw materials in parts by weight: 60-80 parts by weight of deionized water, 2-5 parts by weight of a thickening component, 1-3 parts by weight of a chamomile flower extract, 0.5-1 parts by weight of a preservative, 0.5-1 parts by weight of lactic acid, 0.1-0.5 parts by weight of allantoin, 1-3 parts by weight of a tocopherol nicotinate stock solution, 0.5-2 parts by weight of polysorbate-20 and 1-2 parts by weight of a hydrolyzed actin stock solution.

2. A compact thixotropic gel with sustained release effect according to claim 1, characterized in that: The thickening component comprises: aloe vera leaf juice, sodium alginate, mushroom extract, red radish extract, shiitake mushroom extract, and inonotus obliquus extract, and the mass ratio of the aloe vera leaf juice, sodium alginate, mushroom extract, red radish extract, shiitake mushroom extract, and inonotus obliquus extract is 6-10:2-4:1-3:1-3:1-3:1-3:1-3.

3. The compact thixotropic gel with sustained release effect according to claim 1, characterized in that: The preservatives include phenoxyethanol, caprylyl glycol and benzoic acid, and the mass ratio of phenoxyethanol, caprylyl glycol and benzoic acid is 0.8-1:0.4-0.6:0.2-0.

3.

4. The compact thixotropic gel with sustained release effect according to claim 1, characterized in that: The tocopherol nicotinate stock solution comprises tocopherol nicotinate and caprylic / capric triglyceride, and the mass ratio of the tocopherol nicotinate to caprylic / capric triglyceride is 1:3-7.

5. The compact thixotropic gel with sustained release effect according to claim 1, characterized in that: The hydrolyzed actin stock solution comprises deionized water, 1.2-hexanediol, and hydrolyzed actin, and the mass ratio of the deionized water, 1.2-hexanediol, and hydrolyzed actin is 50-80:5-20:0.1-5.

6. A method for preparing a compact thixotropic gel with sustained release effect as claimed in any one of claims 1 to 5, characterized in that: The following steps are involved: (1) Heat deionized water to 85-90°C, keep the temperature at 80±5°C, add thickening ingredients, mix and disperse homogeneously, and stir until completely dissolved; (2) Cooling to 45° C., adding chamomile extract and preservatives while stirring, and mixing evenly; (3) Add allantoin and hydrolyzed actin stock solution and stir evenly; (4) Add polysorbate 20 and stir evenly; (5) After uniformly mixing the tocopherol nicotinate stock solution, add it into the material and stir evenly; (6) Add lactic acid to adjust the pH value.

7. The method for preparing a compact thixotropic gel with sustained release effect according to claim 6, characterized in that: The pH value of step (6) is 3.8-5.8.