A sunscreen and whitening composition and its preparation method and application

Abstract

The present invention belongs to the field of cosmetics technology, specifically to a sunscreen and whitening composition, its preparation method, and its application. The present invention utilizes a combination of various functional ingredients, including ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizate, aloe vera juice, squalane, Chuanxiong extract, and Scutellaria baicalensis extract, to synergistically block UVA and UVB rays across the entire wavelength range and provide five-fold benefits: sunscreen, whitening, moisturizing, soothing, and repairing. This addresses the problem of many products on the market that offer only sunscreen without whitening and skincare benefits, providing effective skincare and protection.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a sunscreen and whitening composition, a preparation method and an application thereof. Background Art

[0002] Ultraviolet radiation is a major cause of skin cancer and skin aging. It can damage the skin through the following mechanisms: 1. DNA damage. 2. Cross-linking of proteins (such as collagen). 3. Reduced immune response by inducing inhibitory pathways in response to antigenic stimulation. 4. Generation of highly reactive free radicals that interact with various intracellular structures, causing cell and tissue damage.

[0003] There are many sunscreen products on the market, but these products generally only have a single sunscreen function and have poor whitening and skin care protection effects. Summary of the Invention

[0004] To solve the above problems, the present invention combines multiple functional ingredients to synergistically block UVA and UVB in the entire band, and provides five-fold effects of sun protection, whitening, moisturizing, soothing, and repairing. This solves the problem that many products on the market only provide sun protection but do not have whitening and skin care effects, and provides effective skin care protection functions for the skin.

[0005] Specifically, the present invention provides a sunscreen composition comprising the following raw materials: bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizate, aloe juice, squalane, Chuanxiong extract and Scutellaria baicalensis extract.

[0006] Furthermore, the mass percentage content of the raw materials in the sunscreen composition is: ethylhexyl triazone 0.2%-3.5%, diethylamino hydroxybenzoyl hexyl benzoate 0.2%-5.5%, bis-ethylhexyloxyphenol methoxyphenyl triazine 0.2%-5.0%, niacinamide 0.01%-3.0%, glycyrrhizin 0.00001%-0.1%, ascorbic acid derivative 0.01%-0.5%, sodium hyaluronate 0.001%-0.2%, bisabolol 0.1%-0.3%, dipotassium glycyrrhizate 0.001%-0.2%, aloe vera juice 0.1%-3.0%, squalane 0.05%-3.0%, Chuanxiong extract 0.5%-2.0% and Scutellaria baicalensis extract 1.0%-2.0%.

[0007] Furthermore, the mass percentage content of the raw materials in the sunscreen composition is: 1.0% of ethylhexyl triazone, 5.0% of bis-ethylhexyloxyphenol methoxyphenyl triazine, 1.5% of diethylamino hydroxybenzoyl hexyl benzoate, 0.5% of niacinamide, 0.002% of glycyrrhizin, 0.11% of ascorbic acid derivative, 0.01% of sodium hyaluronate, 0.2% of bisabolol, 0.1% of dipotassium glycyrrhizate, 0.9% of aloe vera juice, 0.2% of squalane, 1.0% of Chuanxiong extract and 1.5% of Scutellaria baicalensis extract.

[0008] Furthermore, the composition also contains: 10-16% of cyclopentasiloxane, 4-9% of polydimethylsiloxane, 1.5-6.5% of PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 6-12% of polyol, 0.8-3% of disteardimonium hectorite, 4-6% of isohexadecane, 0-0.5% of preservative, 0-3% of pigment and the balance of water.

[0009] Further, the polyol includes at least one of glycerol, butanediol and 1,2-hexanediol.

[0010] Furthermore, the ascorbic acid derivative is 3-o-ethyl ascorbic acid.

[0011] Furthermore, the preservative includes phenoxyethanol.

[0012] Furthermore, the pigment includes CI 77891.

[0013] Furthermore, the Chuanxiong extract is prepared as follows: taking Chuanxiong medicinal materials, crushing and sieving, placing them in a subcritical fluid extraction tank, adding subcritical fluid, extracting them 2-3 times at 35-55° C. for 30-60 minutes, separating the extractant, and recovering Chuanxiong volatile oil to obtain the extract.

[0014] Furthermore, the scutellaria baicalensis extract is prepared as follows: taking scutellaria baicalensis medicinal materials, crushing and sieving, placing them in a subcritical fluid extraction tank, adding subcritical fluid, extracting them 2-3 times at 35-55° C. for 30-60 minutes, separating the extractant, and recovering scutellaria baicalensis volatile oil to obtain the product.

[0015] Furthermore, the subcritical fluid is butane.

[0016] On the other hand, the present invention also provides a method for preparing the sunscreen composition described herein, comprising the following steps:

[0017] Ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, squalane, cyclopentasiloxane, dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, isohexadecane, and polyol were heated and stirred to obtain an oil phase;

[0018] Heat and stir water, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizate, and disteardimethylammonium hectorite to obtain an aqueous phase;

[0019] The oil phase is added to the water phase, stirred and mixed, cooled, and then the remaining raw materials are added, stirred and mixed to obtain a sunscreen composition.

[0020] Furthermore, when preparing the oil phase, the heating temperature is 70-85° C. and the time is 0.1-1 hour.

[0021] Furthermore, when preparing the oil phase, the heating temperature is 40-50° C. and the time is 0.1-1 hour.

[0022] Furthermore, the oil phase is added to the water phase, stirred and mixed for 0.1-1 hour, cooled to 25-37° C., and then the remaining raw materials are added, stirred and mixed for 0.1-1 hour to obtain a sunscreen composition.

[0023] On the other hand, the present invention also provides the use of the sunscreen composition described herein in the preparation of sunscreen, whitening, moisturizing, soothing and repairing cosmetics.

[0024] Beneficial effects of the present invention:

[0025] This invention addresses the problem that existing sunscreen products only provide sun protection but lack whitening and skincare benefits. By combining multiple functional ingredients, this product synergistically blocks UVA and UVB rays across the entire wavelength range, providing five-fold benefits: sun protection, whitening, moisturizing, soothing, and repairing. Specifically, this invention incorporates a variety of ingredients, including bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, niacinamide, glabridin, a VC derivative (ascorbic acid derivative), sodium hyaluronate, bisabolol, dipotassium glycyrrhizate, aloe vera juice, squalane, Chuanxiong extract, and Scutellaria baicalensis extract. Among them, different sunscreen ingredients provide full-band protection for UVA and UVB, have fast onset and high stability, and are not easily decomposed by ultraviolet rays under long-term exposure; different whitening ingredients whiten through multiple pathways of action, together constituting multi-faceted whitening to achieve a whitening effect; deep moisturizing ingredients with different molecular weights provide deep moisturizing, enhance the skin's water retention and deep moisturizing, effectively enhance the skin's moisturizing ability, reduce water loss after sun exposure, and keep the skin hydrated and refreshed; different anti-irritation ingredients such as bisabolol and dipotassium glycyrrhizate can soothe and resist irritation, preventing skin irritation caused by sunscreen; different repairing ingredients such as aloe vera juice and squalane have a repairing effect on sun-damaged skin; the addition of different plant extracts not only increases the sun protection effect, but also provides better effects in whitening, moisturizing, oil control and repair. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 : Skin condition before and after using Composition 1 sunscreen composition. DETAILED DESCRIPTION

[0027] The present invention will be further described below in conjunction with specific embodiments, but the embodiments do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0028] The present invention provides a sunscreen composition, the formula and proportion of which are shown in Table 1, and the preparation method thereof comprises the following steps:

[0029] The raw materials and amounts of compositions 1-3 are shown in Table 1, and the amounts are measured in mass percentage.

[0030] Table 1: Compositions of compositions 1-3

[0031]

[0032]

[0033] In the above composition, the preparation method of aloe vera juice is as follows: peeling aloe vera leaves, taking aloe vera leaf pulp, adding 1.5 times the mass of water, and squeezing the juice to obtain the aloe vera juice.

[0034] The preparation method of Chuanxiong extract is as follows: taking Chuanxiong medicinal material, crushing it through a 100-mesh sieve, putting it into a subcritical fluid extraction tank, adding subcritical fluid butane, with a mass ratio of Chuanxiong powder to butane of 1:2, extracting three times at 50°C, with a total extraction time of 50 minutes (the first to third extraction times are 20 minutes, 15 minutes and 15 minutes respectively), separating the extractant butane, recovering Chuanxiong volatile oil, and obtaining the Chuanxiong extract.

[0035] The preparation method of the scutellaria baicalensis extract is as follows: scutellaria baicalensis is taken, crushed and passed through a 100-mesh sieve, placed in a subcritical fluid extraction tank, and subcritical fluid butane is added, with the mass ratio of scutellaria baicalensis powder to butane being 1:2.5. The extraction is performed three times at 50°C, with a total extraction time of 55 minutes (the first to third extraction times are 25 minutes, 20 minutes and 10 minutes, respectively), the extractant butane is separated, and the volatile oil of scutellaria baicalensis is recovered to obtain the scutellaria baicalensis extract.

[0036] The preparation method of the above composition is as follows:

[0037] Ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, squalane, cyclopentasiloxane, polydimethylsiloxane, PEG-9 polydimethylsiloxyethyl dimethicone, isohexadecane, and polyol were heated at 78° C. and stirred at 60 rpm for 0.4 hour to obtain an oil phase;

[0038] Mix water, niacinamide, glabridin, ascorbic acid derivative, sodium hyaluronate, bisabolol, dipotassium glycyrrhizate, and disteardimethylammonium hectorite under heating at 45° C. and stirring at 65 rpm for 0.3 hour to obtain an aqueous phase;

[0039] The oil phase was added to the water phase, stirred at 60 rpm for 0.4 hours to mix, cooled to 32° C., and then the remaining raw materials were added, stirred at 60 rpm for 0.3 hours to mix, to obtain a sunscreen composition.

[0040] Composition 4:

[0041] The only difference from composition 1 is that ethylhexyl triazone is not contained and the amount thereof is made up with an equal amount of water.

[0042] Composition 5:

[0043] The only difference from composition 1 is that it does not contain diethylamino hydroxybenzoyl hexyl benzoate, and its amount is made up by an equal amount of water.

[0044] Composition 6:

[0045] The only difference from composition 1 is that bis-ethylhexyloxyphenol methoxyphenyl triazine is not contained and the amount thereof is made up with an equal amount of water.

[0046] Composition 7:

[0047] The only difference from composition 1 is that it does not contain ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate and bis-ethylhexyloxyphenol methoxyphenyl triazine, and their amounts are made up with an equal amount of water.

[0048] Composition 8:

[0049] The only difference from composition 1 is that it does not contain Chuanxiong extract and Scutellaria baicalensis extract, and their amounts are supplemented with an equal amount of water.

[0050] Composition 9:

[0051] This composition differs from Composition 1 in that the preparation methods for the Chuanxiong extract and the Scutellaria baicalensis extract are different. The Chuanxiong extract in this composition is prepared as follows: Chuanxiong medicinal material is ground and passed through a 100-mesh sieve, 20 times the mass concentration of 65% ethanol is added, and the mixture is stirred at 55°C and 60 rpm for 2 hours. The mixture is concentrated and freeze-dried at -35°C to a water content of 3.54%, thereby obtaining the Chuanxiong extract.

[0052] The preparation method of the scutellaria baicalensis extract is as follows: take scutellaria baicalensis, grind it through a 100-mesh sieve, add 22 times the mass concentration of 70% ethanol, stir at 55°C and 60rpm for 2.5 hours, concentrate, and freeze-dry at -37°C to a water content of 3.27% to obtain the scutellaria baicalensis extract.

[0053] Composition 10:

[0054] The difference from composition 1 is that 1% of Chuanxiong extract and 1.5% of Scutellaria baicalensis extract are replaced by 2.5% of Chuanxiong extract, and the rest are the same as composition 1.

[0055] Composition 11:

[0056] The difference from composition 1 is that 1% of Chuanxiong extract and 1.5% of Scutellaria baicalensis extract are replaced by 2.5% of Scutellaria baicalensis extract, and the rest are the same as composition 1.

[0057] Test Example 1: Sunscreen Effect Test

[0058] The composition and the sample of the composition were measured at 2 mg / cm 2 The coating density was evenly coated on the PMMA board and scanned and tested using an SPF-290S UV spectrophotometer. The SPF values ​​of the test data are shown in Table 2.

[0059] Table 2: Sunscreen effect test

[0060] test SPF value Composition 1 48.9 Composition 2 47.6 Composition 3 48.1 Composition 4 38.3 Composition 5 39.6 Composition 6 37.2 Composition 7 28.5 Composition 8 42.4 Composition 9 45.1 Composition 10 47.0 Composition 11 47.3

[0061] As can be seen from the data in Table 2, when composition 7 does not contain ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, and bis-ethylhexyloxyphenol methoxyphenyl triazine, its sun protection index is significantly lower than that of the sample of composition 1. However, the sun protection index of compositions 4-6, which do not contain any of the three, is very poor, indicating that ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, and bis-ethylhexyloxyphenol methoxyphenyl triazine can synergistically enhance the sunscreen effect of the sunscreen composition. From the results of the tests on compositions 8-11, it can be seen that the Chuanxiong extract and the Scutellaria baicalensis extract added in the present invention can enhance the overall sunscreen effect of the composition, and the extraction methods of the Chuanxiong extract and the Scutellaria baicalensis extract have a significant effect on the sunscreen effect enhancement effect. The combination of the two can also mutually promote the sunscreen effect of the composition to a certain extent.

[0062] Test Example 2: Refreshing and moisturizing effect test

[0063] The refreshing and moisturizing effect was characterized by measuring skin oil and water content. The specific method was: 42 subjects aged 30 to 45 were randomly selected, including 21 males and 21 females. The subjects were then randomly divided into 7 groups, each with 6 subjects (3 males and 3 females). These groups were labeled as compositions 1-3 and 8-11. The subjects in each group then used the prepared sunscreen composition that matched their group. After 40 minutes of use, the skin oil content and skin water content were measured using a Sebumeter and a Corneometer CM825, respectively, before and after application. The average values ​​of skin oil and water content for each group were recorded and reported in Table 3 below.

[0064] Table 3: Refreshing and moisturizing effect test

[0065]

[0066]

[0067] As can be seen in Table 3, the sunscreen compositions prepared from compositions 1-3 and 8-11 all showed increased moisture content and decreased oil content after use compared to pre-use, demonstrating excellent moisturizing and refreshing skin feel. Composition 1 exhibited superior moisturizing and oil control effects compared to composition 8, which lacked Chuanxiong extract and Scutellaria baicalensis extract, composition 9, which was prepared using a different extraction process, and compositions 10-11, which contained either Chuanxiong extract or Scutellaria baicalensis extract. This demonstrates that the combination of Chuanxiong and Scutellaria baicalensis, as well as the extraction method, significantly impacted the moisturizing and oil control properties of the compositions.

[0068] Test Example 3: UVB-induced photodamage test of HaCaT cells

[0069] The products of compositions 1-3 and 8-11 were freeze-dried and dissolved in MEM complete medium at a concentration of 1 mg / mL. The pH value was adjusted to 7.0, and sterilized by filtration with a 0.22 μm pore size filter membrane. The cells were stored at 4°C and diluted with MEM complete medium to the required concentration (50 μg / mL) for the experiment. HaCaT cells in the logarithmic phase were inoculated into 96-well plates and cultured in a 37°C, 5% CO2 incubator. After the cells adhered to the wall, they were divided into a normal control group, a model control group, and the compositions 1-3 and 811 groups of the present invention, with 6 replicates in each group. After 24 hours of culture, 60 mJ / cm 2UVB irradiation was performed and the cells were cultured for 24 hours. Cell viability was determined using the MTT assay. 20 μL of 5 mg / mL MTT was added to each well (containing 180 μL of culture medium) and incubated for 4 hours. The supernatant was discarded, and 150 μL of DMSO was added. The cells were shaken in a constant temperature shaker for 10 minutes. The absorbance (OD) of each well was measured at 492 nm using a microplate reader. The results are shown in Table 4.

[0070] Table 4: Absorbance value (OD value)

[0071] Group OD value Normal control group 1.032±0.098 Model control group 0.575±0.063 Composition 1 0.767±0.082 Composition 2 0.756±0.071 Composition 3 0.762±0.078 Composition 8 0.671±0.052 Composition 9 0.702±0.065 Composition 10 0.739±0.080 Composition 11 0.748±0.067

[0072] As can be seen from the data in Table 4, compared with the normal control group, the cell activity of the model control group decreased significantly, indicating that the modeling was successful. The sample of composition 1 can enhance cell activity, indicating that it can significantly reduce the light damage of UVB-induced HaCaT cells, has obvious anti-skin photoaging effect, and therefore has a repairing effect. In contrast, it can be seen from the results of composition 8 that the Chuanxiong extract and Scutellaria extract added in the present invention can enhance the cell activity enhancement effect of the composition, and from the results of composition 9, it can be seen that the extraction method of Chuanxiong extract and Scutellaria extract has a significant effect on the cell activity enhancement effect, and from the results of compositions 10-11, it can be seen that the combination of Chuanxiong extract and Scutellaria extract obtained by the specific extraction process of the present invention can mutually promote the cell activity enhancement effect of the composition.

[0073] Test Example 4: Whitening and Repair Test

[0074] Six female volunteers aged 20-40 with healthy skin were selected and the sunscreen composition prepared by Composition 1 was applied on their faces for 1 month to observe the skin care effect on their facial skin.

[0075] The test showed that the facial skin of the six volunteers became whiter, smoother and more moisturized.

[0076] in, Figure 1 Shows the changes in a volunteer's facial skin before and after using the sunscreen composition of composition 1. Figure 1 It can be seen that after applying the sunscreen composition prepared by composition 1 on the face for one month, the face will be whitened, repaired and moisturized.

[0077] It should also be noted that the various technical features described in the above invention can be modified and combined in any legal manner without any contradiction. To avoid unnecessary repetition, the present invention will not further provide descriptions of various possible other proportion combinations. In addition, the various different technical solutions of the present invention can also be combined in any way. As long as they do not violate the core content of the solution of the present invention, they should be equivalent to the content described in the present invention.

Claims

1. A sunscreen composition, characterized in that Calculated by mass percentage, the raw materials include: ethylhexyl triazone 0.2%-3.5%, diethylamino hydroxybenzoyl hexyl benzoate 0.2%-5.5%, bis-ethylhexyloxyphenol methoxyphenyl triazine 0.2%-5.0%, niacinamide 0.01%-3.0%, glabridin 0.00001%-0.1%, ascorbic acid derivative 0.01%-0.5%, sodium hyaluronate 0.001%-0.2%, bisabolol 0.1%-0.3%, dipotassium glycyrrhizate 0.001%-0.2%, aloe vera juice 0.1%-3.0%, squalane 0.05%-3.0%, chuanxiong extract 0.001%-2.0% and scutellaria baicalensis extract 0.001%-2.0%; The Chuanxiong extract is prepared as follows: taking Chuanxiong, crushing and sieving, placing it in a subcritical fluid extraction tank, adding subcritical fluid, extracting 2-3 times at 35-55° C. for 30-60 minutes, separating the extractant, and recovering the Chuanxiong volatile oil to obtain the extract; The scutellaria baicalensis extract is prepared as follows: taking scutellaria baicalensis, crushing and sieving, placing in a subcritical fluid extraction tank, adding subcritical fluid, extracting 2-3 times at 35-55° C. for 30-60 minutes, separating the extractant, and recovering the volatile oil of scutellaria baicalensis to obtain; The ascorbic acid derivative is 3-o-ethyl ascorbic acid.

2. The sunscreen composition according to claim 1, characterized in that Calculated in terms of mass percentage, the raw materials include: 1.0% ethylhexyl triazone, 1.5% diethylamino hydroxybenzoyl hexyl benzoate, 1.0% bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.5% niacinamide, 0.002% glabridin, 0.11% ascorbic acid derivative, 0.01% sodium hyaluronate, 0.2% bisabolol, 0.1% dipotassium glycyrrhizate, 0.9% aloe juice, 0.2% squalane, 1.0% ligusticum chuanxiong extract and 1.5% scutellaria baicalensis extract.

3. The sunscreen composition according to claim 1 or 2, characterized in that Calculated by mass percentage, the raw materials also include: 10-16% cyclopentasiloxane, 4-9% polydimethylsiloxane, 1.5-6.5% PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, 6-12% polyol, 0.8-3% disteardimonium hectorite, 4-6% isohexadecane, 0-0.5% preservative, 0-3% pigment and the balance water.

4. The sunscreen composition according to claim 3, characterized in that The polyol includes at least one of glycerol, butylene glycol, ethylene glycol, propylene glycol and hexylene glycol.

5. The sunscreen composition according to claim 3, characterized in that Preservatives include phenoxyethanol.

6. The sunscreen composition according to claim 3, characterized in that Colorants include CI 77891.

7. A method for preparing the sunscreen composition according to any one of claims 3 to 6, characterized in that: The steps include: Ethylhexyl triazone, diethylamino hydroxybenzoyl hexyl benzoate, bis-ethylhexyloxyphenol methoxyphenyl triazine, squalane, cyclopentasiloxane, dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, isohexadecane, and polyol were heated and stirred to obtain an oil phase; Heat and stir water, niacinamide, glabridin, ascorbic acid derivatives, sodium hyaluronate, bisabolol, dipotassium glycyrrhizate, and disteardimethylammonium hectorite to obtain an aqueous phase; The oil phase is added to the water phase, stirred and mixed, cooled, and then the remaining raw materials are added, stirred and mixed to obtain a sunscreen composition.

8. Use of the sunscreen composition according to any one of claims 1 to 6 in the preparation of sunscreen, whitening, moisturizing, soothing or repairing cosmetics.

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