A device for detecting NO and H2S in oral gas
By incorporating filtration and moisture-filtering channels into the oral gas detection device, combined with sensors and a buffer chamber, the problems of oral condensation and bacterial interference are solved, achieving high-precision NO and H2S detection, reducing costs, and making it suitable for multiple uses.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SUNVOU MEDICAL ELECTRONICS
- Filing Date
- 2024-12-03
- Publication Date
- 2026-05-12
AI Technical Summary
Existing oral gas detection technologies cannot effectively avoid the impact of oral aerosol condensation on sampling and testing, as well as the interference of oral microorganisms on test results, resulting in low detection accuracy.
The gas collection device employs a filtration module, which includes an intake channel and a moisture filtration channel. These channels are filled with filter particles and dry particles, respectively, to remove environmental interference components and dry the oral gas. Combined with the sensors and buffer chamber in the gas analysis device, the concentration of the analyte is calculated using the current difference.
It improves the detection accuracy of NO and H2S in oral gases, simplifies the structure, reduces costs, and is suitable for the needs of multiple uses and rapid detection in clinical diagnosis.
Smart Images
Figure CN119632541B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of gas composition analysis and detection technology, and in particular to a device for detecting NO and H2S in oral gases. Background Technology
[0002] According to relevant statistics, oral diseases are the most common non-communicable diseases, with an average incidence rate as high as 45%, estimated at nearly 3.5 billion cases, far exceeding other non-communicable diseases. However, oral health has long been neglected in the health sector, with low levels of attention and high treatment costs, and is usually not covered by universal health insurance. Therefore, early screening and early diagnosis are particularly important for the prevention of oral diseases.
[0003] Oral disease detection often involves various methods such as oral endoscopy, X-ray, and CT scans. Compared with other methods, oral gas detection is convenient, highly sensitive, allows for early screening and diagnosis, and enables early intervention to prevent aggravation. In recent years, it has become a research hotspot as a novel diagnostic method. Studies have found that the levels of NO and H2S in the oral cavity are highly correlated with oral diseases, and NO and H2S play important regulatory roles in the physiological and pathological processes of the oral mucosa. Oral NO is mainly produced by tissue cell metabolism, primarily through the oxidation and deamination of arginine in cortical cells under the action of NO synthase (iNOS). Oral H2S is mainly produced by bacterial metabolism, with major producing bacteria including Porphyromonas gingivalis, Treponema denticulatum, Forsythorbates, and Clostridium moorei. Inflammation and pathogenic bacterial overgrowth are two major diagnostic and treatable features of oral diseases such as periodontal disease. Therefore, the measurement of inflammatory marker NO and bacterial metabolite H2S can serve as potential tools for screening and diagnosis. If combined detection of oral NO and H2S can be performed, oral inflammation and bacterial metabolism can be better assessed. Clinical applications can be extended beyond halitosis to the screening or diagnosis of oral diseases such as periodontal disease, allowing for early intervention and prevention of disease progression.
[0004] Existing oral gas detection technologies primarily target the detection of sulfides such as H2S in the mouth associated with halitosis, such as the Halimeter from the United States and the Oral Chroma from Japan. Oral Chroma uses a syringe to collect a small amount of gas from the mouth, which avoids condensation, but due to the limitations of chromatographic detection, the sample size is very small, resulting in poor repeatability. Halimeter uses a mouth-held catheter for sampling, with the catheter directly connected to the instrument for analysis. However, there is no drying device in the tubing to dehumidify the extracted oral gas, causing water vapor in the oral gas to condense on the tube wall. Since H2S is highly soluble in water, the H2S concentration in the oral gas decreases due to dissolution in the condensate, severely affecting the collection of oral gas and the final detection accuracy. Statistics show that the H2S concentration results obtained by Halimeter are 1-2 times lower than those of Oral Chroma. Patent CN117618031A also discloses an oral gas detection device, but does not disclose a solution to address the impact of oral gas condensation on sampling and testing.
[0005] In addition to NO and H2S, oral microbiota also produces various other compounds, such as caries-associated bacteria (Streptococcus mutans, Lactobacillus acidophilus, and Propionibacterium acidophilus), which produce compounds including cyclohexanone, pentanone, octanal, and dimethyl sulfide; saliva-associated bacteria (Klebsiella pneumoniae and Staphylococcus aureus), which produce compounds including short-chain and medium-chain fatty acids such as acetic acid and butyric acid, as well as S-methylpentyl sulfate; tongue-derived microorganisms, especially anaerobic bacteria associated with the tongue surface, which produce compounds including indole, ammonia, and methyl methacrylate; and subgingival anaerobic bacteria (Spirometra, Prevotella intermedius, Prevotella niger, and Forsell), which produce compounds including methanethiol, dimethyl disulfide, and methanol. All of these compounds can potentially interfere with the detection of NO and H2S, affecting the accuracy of the test results.
[0006] Therefore, how to provide a detection device for NO and H2S in oral gases that can effectively avoid the influence of oral aerosol condensation on sampling and testing, as well as the influence of various microorganisms produced by oral flora on test results, and effectively improve the detection accuracy of NO and H2S in oral gases, is a problem that urgently needs to be solved by those skilled in the art. Summary of the Invention
[0007] In view of this, the present invention proposes a device for detecting NO and H2S in oral gas.
[0008] To achieve the above objectives, the present invention adopts the following technical solution:
[0009] A device for detecting NO and H2S in oral gas includes: a gas collection device and a gas analysis device;
[0010] The gas collection device includes: a sampling module and a filtering module;
[0011] The filter module has two channels: an air intake channel and a moisture filtration channel.
[0012] The intake channel is filled with filter particles, and the moisture filtration channel is filled with dry particles.
[0013] The sampling module includes a connecting part, a collection part fixed to one end of the connecting part, and a sampling channel passing through the collection part and the connecting part; the collection part is placed inside the oral cavity;
[0014] The connecting part is equipped with an air inlet and an air outlet that are connected to the sampling channel. The air inlet is connected to the air intake channel of the filter module, and the air outlet is connected to the moisture filtration channel of the filter module.
[0015] The gas analysis device includes: a gas extraction control module and a detection module;
[0016] One end of the gas extraction control module is connected to the moisture filtration channel of the filter module, and the other end is connected to the detection module.
[0017] The detection module includes: a CO2 sensor, an H2S sensor, a NO sensor, a gas filter, and a buffer chamber connected in series;
[0018] The gas extraction control module includes: a sampling pump and a four-way control valve;
[0019] The sampling pump draws ambient air through the intake channel of the filtration module into the sampling channel and the oral cavity. The oral cavity air then passes through the sampling channel and the moisture-filtering channel into the CO2 sensor, H2S sensor, and NO sensor for measurement, and then enters the buffer chamber through the gas filter. The state of the four-way control valve is switched so that the sampling pump draws the filtered gas from the buffer chamber and passes it into the CO2 sensor, H2S sensor, and NO sensor for measurement. The concentration data of the component to be measured is calculated by the corresponding current difference of the oral cavity gas before and after filtration.
[0020] Optionally, the sampling module is a detachable, disposable product.
[0021] Optionally, the filter particles are aluminum oxide particles loaded with potassium permanganate or platinum black.
[0022] Optionally, the dried granules are plant fiber or glass fiber granules loaded with anhydrous calcium chloride or anhydrous magnesium sulfate.
[0023] Optionally, the preparation process of dried granules involves mixing anhydrous calcium chloride or anhydrous magnesium sulfate with plant fiber or glass fiber slurry in a preset ratio, granulating, and then drying in an oven.
[0024] Optionally, the collecting part is provided with at least one diffusion hole.
[0025] Optionally, the gas extraction control module can control the gas extraction flow rate according to different needs.
[0026] As can be seen from the above technical solution, compared with the prior art, this invention proposes a detection device for NO and H2S in oral gas. By setting an intake channel filled with filter particles in the ambient air delivery path and a moisture-filtering channel filled with dry particles in the oral gas return path, and integrating the two channels into a single filter module, not only are interfering components in the ambient air removed, but the extracted oral gas is also dried, avoiding the generation of condensation. This ensures that the device does not adsorb the components to be detected, nor does it release interfering substances that affect the detection of the components to be detected, effectively improving the detection accuracy of NO and H2S in oral gas. Moreover, compared with existing collection devices, it achieves a simpler structure and lower cost. By designing the sampling module and the filter module separately, and designing the sampling module, which directly contacts the cavity, as a disposable item, cross-contamination is avoided, and the consumable cost of the device is effectively reduced. By adopting a dry particle manufacturing process of mixing slurry first and then granulating and drying, it is simpler than existing processes, and the produced dry particles have a higher moisture absorption rate, reaching 100% of their own weight, achieving good moisture absorption efficiency, high moisture absorption stability, and a longer service life. By simultaneously collecting filtered gas in a buffer chamber while measuring oral gas, subsequent measurements only require measuring the filtered gas again. This reduces the overall sampling and analysis time by at least 50% compared to the traditional method of sampling first and then analyzing, making it suitable for multiple uses and rapid testing needs in clinical diagnosis. Attached Figure Description
[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.
[0028] Figure 1 This is a schematic diagram of the device structure of the present invention.
[0029] Figure 2 This is a schematic diagram of the physical structure of the gas collection device of the present invention.
[0030] 1-Sampling module, 2-Filtering module, 11-Connecting part, 12-Collection part, 13-Sampling channel, 121-Diffusor hole, 21-Inhalation channel, 22-Moisture filtration channel. Detailed Implementation
[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0032] Example 1:
[0033] Embodiment 1 of the present invention discloses a device for detecting NO and H2S in oral gas, such as... Figure 1 As shown, it includes: a gas collection device and a gas analysis device;
[0034] Gas collection devices, such as Figure 2 As shown, it includes: sampling module 1 and filtering module 2;
[0035] The filter module 2 has two channels, namely the air intake channel 21 and the moisture filtration channel 22. They are integrally molded, with a simple structure, which is conducive to assembly and has a lower cost.
[0036] The intake channel 21 is filled with filter particles, which can filter out interfering components in the ambient air and supply ambient air that does not interfere with the components to be detected, thus eliminating the influence of the environment on the detection results. The humidification channel 22 is filled with drying particles, which are used to dry the extracted oral gas, avoiding the generation of condensation water, and will not adsorb the components to be detected or release interfering substances that affect the detection of the components to be detected.
[0037] The sampling module 1 includes a connecting part 11, a collection part 12 fixed to one end of the connecting part 11, and a sampling channel 13 passing through the collection part 12 and the connecting part 11; the collection part 12 is placed inside the oral cavity;
[0038] The connecting part 11 is provided with an air inlet and an air outlet that are connected to the sampling channel 13. The air inlet is connected to the air intake channel 21 of the filter module 2, and the air outlet is connected to the moisture filtration channel 22 of the filter module 2.
[0039] The gas analysis device includes: a gas extraction control module and a detection module;
[0040] One end of the gas extraction control module is connected to the humidification channel 22 of the filter module 2, and the other end is connected to the detection module.
[0041] The detection module includes: a CO2 sensor, an H2S sensor, a NO sensor, a gas filter, and a buffer chamber connected in series; in addition, sensors for detecting other components can be added according to other actual detection needs.
[0042] The gas extraction control module includes: a sampling pump and a four-way control valve;
[0043] The sampling pump draws ambient air through the intake channel 21 of the filter module 2 into the sampling channel 13 and the oral cavity. The oral cavity gas then passes through the sampling channel 13 and the humidification channel 22 before entering the CO2, H2S, and NO sensors for measurement. It then passes through a gas filter into a buffer chamber (at this time, the gas in the original buffer chamber is discharged through a four-way valve). This invention simultaneously collects filtered gas in the buffer chamber while measuring oral cavity gas, so that subsequent measurements only need to be taken of the filtered gas. The overall sampling and analysis time is reduced by at least 50% compared to the traditional method of sampling first and then analyzing, making it suitable for multiple uses and rapid testing needs in clinical diagnosis. Switching the state of the four-way control valve allows the sampling pump to draw filtered gas from the buffer chamber and pass it into the CO2, H2S, and NO sensors for measurement. The concentration data of the analyte is calculated based on the corresponding current difference between the oral cavity gas before and after filtration. Calculating gas component concentration data based on current difference is existing technology in this field and will not be elaborated here.
[0044] The sampling pump flow rate was set to 5 ml / s, the buffer chamber volume to 50 ml, the sampling time to 10 s, and the analysis time to 10 s. Oral air was analyzed simultaneously during sampling, and the filtered oral air was stored in the buffer chamber. After sampling, only the filtered oral air needed to be analyzed again. The overall sampling and analysis time was shortened by at least 50% compared to the traditional method of sampling first and then analyzing.
[0045] Optionally, sampling module 1 is a detachable, disposable product, which can effectively avoid cross-infection. Filter module 2, which does not come into contact with the oral cavity, can be used multiple times. This separate design not only avoids the risk of cross-infection but also reduces the cost of consumables and simplifies assembly.
[0046] Optionally, the filter particles are aluminum oxide particles loaded with potassium permanganate or platinum black.
[0047] Alumina particles loaded with potassium permanganate, with a particle size of 0.5-1.5 mm, can remove nitric oxide, hydrogen sulfide, methanethiol, methanol, acetaldehyde, ethanol, diethyl ether, ethyl acetate, isobutanol, etc.
[0048] Alumina particles loaded with platinum black can remove carbon monoxide, nitrogen oxides, hydrogen sulfide, etc.
[0049] Both types of filter particles can completely filter NO and H2S, meeting ambient air filtration requirements.
[0050] Optionally, the dried granules are plant fiber or glass fiber granules loaded with anhydrous calcium chloride or anhydrous magnesium sulfate.
[0051] When selecting moisture-absorbing materials, considering various materials, silica gel particles and molecular sieve particles both absorb H2S, with absorption rates of 30-50% and 70-90% for 60ppb H2S, respectively. Anhydrous calcium chloride or anhydrous magnesium sulfate has strong drying capabilities, does not adsorb the components to be detected, and does not release interfering substances that affect the detection of the components. Loading them onto plant fibers or glass fibers can further improve the moisture absorption efficiency.
[0052] Optionally, the preparation process of the dried granules involves mixing anhydrous calcium chloride or anhydrous magnesium sulfate with plant fiber or glass fiber slurry in a preset ratio (in this invention, the preset ratio is 1:3), granulating, and then drying in an oven. The preparation process of mixing the slurry first and then granulating and drying is simpler than the existing process. The dried granules produced have a higher moisture absorption rate, reaching 100% of their own weight, with good moisture absorption efficiency and high moisture absorption stability, and a longer service life.
[0053] Optionally, the collection unit 12 is provided with at least one diffusion hole 121, through which oral gas passes through the diffusion hole 121, the sampling channel 13 and the humidification channel 22 and enters the gas analysis device.
[0054] Optionally, the gas extraction control module can control the gas extraction flow rate according to different needs.
[0055] This invention discloses a device for detecting NO and H2S in oral gas. By setting an intake channel filled with filter particles in the ambient air delivery path and a moisture-filtering channel filled with dried particles in the oral gas return path, and integrating these two channels into a single filter module, not only are interfering components in the ambient air removed, but the extracted oral gas is also dried, preventing condensation. This ensures that the device does not adsorb the components to be detected, nor release interfering substances that affect the detection of the components, effectively improving the detection accuracy of NO and H2S in oral gas. Furthermore, compared to existing collection devices, it achieves a simpler structure and lower cost. By designing the sampling module and filter module separately, and designing the sampling module, which directly contacts the cavity, as a disposable item, cross-contamination is avoided, and the consumable cost of the device is effectively reduced. The dry particle manufacturing process, which involves mixing the slurry first and then granulating and drying, is simpler than existing processes, and the produced dry particles have a higher moisture absorption rate, reaching 100% of their own weight, achieving good moisture absorption efficiency, high moisture absorption stability, and a longer service life. By simultaneously collecting filtered gas in a buffer chamber while measuring oral gas, subsequent measurements only require measuring the filtered gas again. This reduces the overall sampling and analysis time by at least 50% compared to the traditional method of sampling first and then analyzing, making it suitable for multiple uses and rapid testing needs in clinical diagnosis.
[0056] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. Similar or identical parts between embodiments can be referred to interchangeably. For the apparatus disclosed in the embodiments, since they correspond to the methods disclosed in the embodiments, the description is relatively simple; relevant parts can be referred to the method section.
[0057] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims
1. A device for detecting NO and H2S in oral gas, characterized in that, include: Gas collection devices and gas analysis devices; The gas collection device includes: a sampling module (1) and a filtering module (2); The filter module has two channels, namely an air intake channel (21) and a moisture filtration channel (22). The air intake channel (21) is filled with filter particles, and the moisture filtration channel (22) is filled with dry particles; The sampling module (1) includes a connecting part (11), a collection part (12) fixed to one end of the connecting part (11), and a sampling channel (13) passing through the collection part (12) and the connecting part (11); the collection part (12) is placed inside the oral cavity; The connecting part (11) is provided with an air inlet and an air outlet that are connected to the sampling channel (13). The air inlet is connected to the air intake channel (21) of the filter module (2), and the air outlet is connected to the moisture filtration channel (22) of the filter module (2). The gas analysis device includes: a gas extraction control module and a detection module; One end of the gas extraction control module is connected to the humidification channel (22) of the filter module (2), and the other end is connected to the detection module. The detection module includes: a CO2 sensor, an H2S sensor, a NO sensor, a gas filter, and a buffer chamber connected in series; The gas extraction control module includes: a sampling pump and a four-way control valve; The sampling pump draws ambient air through the intake channel (21) of the filter module (2) into the sampling channel (13) and the oral cavity. The oral cavity gas then passes through the sampling channel (13) and the humidification channel (22) into the CO2 sensor, H2S sensor, and NO sensor for measurement, and enters the buffer chamber through the gas filter. The state of the four-way control valve is switched so that the sampling pump draws the filtered gas in the buffer chamber and passes it into the CO2 sensor, H2S sensor, and NO sensor for measurement. The concentration data of the component to be measured is calculated by the corresponding current difference of the oral cavity gas before and after filtration.
2. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that, The sampling module (1) is a detachable, disposable product.
3. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that, The filter particles are aluminum oxide particles loaded with potassium permanganate or platinum black.
4. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that, The dried particles are plant fiber or glass fiber particles loaded with anhydrous calcium chloride or anhydrous magnesium sulfate.
5. The device for detecting NO and H2S in oral gas according to claim 4, characterized in that, The dried granules are prepared by mixing anhydrous calcium chloride or anhydrous magnesium sulfate with plant fiber or glass fiber slurry in a preset ratio, granulating, and then drying in an oven.
6. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that, The collecting part (12) is provided with at least one diffusion hole (121).
7. The device for detecting NO and H2S in oral gas according to claim 1, characterized in that, The gas extraction control module can control the gas extraction flow rate according to different needs.