Mouthwash composition with long-acting antibacterial effect and preparation method thereof

Abstract

The invention relates to a mouthwash composition with a long-acting antibacterial effect. The mouthwash composition with the long-acting antibacterial effect is prepared from the following components in parts by mass: a microcapsule composition, a solvent, a solubilizer, a rheological suspending agent, an auxiliary agent and water, wherein the microcapsule composition comprises a wall material and a core material, and the materials of the wall material comprise cationized polyvinyl alcohol, starch, a cross-linking agent and an electrolyte. According to the mouthwash composition disclosed by the invention, the microcapsule composition with a core-shell structure is added, so that drugs can be effectively and stably slowly released, the residual time of the drugs in an oral cavity is prolonged, and a lasting antibacterial effect is achieved; the cationized polyvinyl alcohol contains a large number of cationic groups, so that the wall material has a good hydrophilic effect after the cationized polyvinyl alcohol is compounded with components such as starch and the like to prepare the wall material.

Description

Technical Field

[0001] The invention belongs to the field of daily chemicals, and particularly relates to a mouthwash composition with long-lasting antibacterial effect and a preparation method thereof. Background Art

[0002] The oral cavity is an effective channel for microorganisms to enter the human body. The oral microbiome is the second largest micro-ecosystem in the human body, containing a large number of pathogenic microorganisms, which cause a variety of oral diseases, including caries, periodontitis, oral ulcers, etc. With the improvement of modern living standards, people's intake of nutrition is becoming more and more abundant. Nutrient-rich food residues have become fertile soil for the growth of microorganisms in the oral cavity, among which there is no lack of excessive growth of a large number of pathogenic microorganisms.

[0003] Dental plaque is the main factor that causes inflammation in teeth and surrounding tissues, and can easily lead to the two most common oral diseases: caries and periodontal disease. In the early stages of periodontitis, the gums become swollen and painful, which hinders chewing and affects eating. In severe cases, it can cause swelling of the cheek on the affected side. Conventional toothbrushing can only remove 40%-50% of the plaque on the tooth surface, and is basically powerless to remove plaque on the surface of oral soft tissues. For common oral diseases such as caries and oral ulcers, a large amount of antibiotics are used during treatment, resulting in an imbalance of oral flora. Mouthwash, as an oral care product, can penetrate into various parts of the mouth to assist in controlling plaque.

[0004] Drug microcapsules are special drug core materials that undergo microencapsulation treatment. Their color, shape, volume, quality, solubility, and storage properties will undergo certain changes. Under certain conditions, the drug core material will be slowly released to exert its effects. The sustained-release effect of drug microcapsules allows the active ingredients in the drug to be slowly released after reaching the site of action in the human body, thereby protecting the oral cavity, stomach, intestines and other body organs from strong drug stimulation, and continuously and evenly administering the drug to achieve effective treatment of targeted parts of the human body. Drug encapsulation and sustained-release technology is widely used in the pharmaceutical field due to its advantages of high drug utilization, lasting efficacy, and few side effects, but it is currently rarely used in the field of mouthwash.

[0005] Therefore, using drug encapsulation and sustained-release technology to encapsulate the active ingredients can reduce the contact between the active ingredients and the outside world, and has the advantages of preventing deterioration, good sustained-release effect, and long-lasting drug efficacy; however, the compatibility of the microcapsule composition with the internal environment of the oral cavity is poor, which can easily lead to a sudden release of the active ingredients in the microcapsules, making it impossible for the active ingredients to play their true role.

[0006] In summary, there is an urgent need to develop a mouthwash composition with long-lasting antibacterial effect to solve the defects in the prior art. Summary of the invention

[0007] The present invention aims at solving the above-mentioned defects and provides a mouthwash composition with long-lasting antibacterial effect and a related preparation method. The microcapsule composition in the product has good hydrophilicity and excellent responsiveness to the human oral environment, and can better improve the problem of sudden release of drugs in the oral cavity to achieve the purpose of sustained release of drugs.

[0008] One object of the present invention is to provide a mouthwash composition with long-lasting antibacterial effect, wherein the mouthwash composition with long-lasting antibacterial effect comprises the following components in mass fractions:

[0009]

[0010] Wherein, the microcapsule composition comprises a wall material and a core material, and the wall material comprises a cationized polyvinyl alcohol, starch, a cross-linking agent and an electrolyte;

[0011] The cationized polyvinyl alcohol is obtained by the reaction of glycidyl trimethylammonium chloride and polyvinyl alcohol;

[0012] The core material comprises an efficacy substance, an efficacy substance sustained-release enhancer and an efficacy substance carrier.

[0013] Furthermore, the mass ratio of the core material to the wall material is 1:10-10:1.

[0014] Preferably, the mass ratio of the core material to the wall material is 1:4-4:1.

[0015] Furthermore, the starch is selected from one or more of corn starch, potato starch, sweet potato starch, rice starch, and millet starch.

[0016] Furthermore, the cross-linking agent is selected from one or more of gellan gum, locust bean gum, gelatin and carrageenan.

[0017] Furthermore, the electrolyte is selected from one or more of inorganic salts and / or organic salts.

[0018] Preferably, the electrolyte is selected from one or more of chlorides, sulfates and citrates.

[0019] Furthermore, the functional substance is selected from one or more of honeysuckle extract, white peony extract, bitter almond extract, dipotassium glycyrrhizinate, zinc lactate, eugenol, tannic acid, cymene, chlorhexidine, cetylpyridinium chloride, and triclosan.

[0020] Furthermore, the functional substance carrier is selected from one or more of cellulose, dextrin or polysaccharide.

[0021] Furthermore, the efficacy substance sustained-release enhancer is selected from one or more of fatty acids or fatty alcohols.

[0022] Furthermore, the particle size of the microcapsule composition is 1-100 μm.

[0023] Preferably, the particle size of the microcapsule composition is 5-50 μm.

[0024] Furthermore, the solvent is selected from one or more of glycerol, propylene glycol, butylene glycol, sorbitol, mannitol, and polyglycerol.

[0025] Furthermore, the solubilizing agent is selected from one or more of polyoxyethylene hydrogenated castor oil and polyglycerol ester surfactants.

[0026] Furthermore, the rheological suspending agent is selected from one or more of xanthan gum, carrageenan, locust bean gum, gellan gum, guar gum and konjac gum.

[0027] Furthermore, the auxiliary agent is selected from one or more of a moisturizer, a taste regulator, a pH regulator, a chelating agent, a flavor, a preservative, an amino acid, and a pigment.

[0028] The present invention also provides a method for preparing the mouthwash composition with long-lasting antibacterial effect, comprising the following steps:

[0029] S1. Under ultrasonic conditions, slowly add glycidyl trimethylammonium chloride to an aqueous solution of polyvinyl alcohol, adjust the pH to 8-10, and react for 1-4 hours. After the reaction is completed, cool to room temperature, adjust the pH to 7-8, and dry to obtain cationic polyvinyl alcohol;

[0030] S2, mixing the components of the wall material except the cross-linking agent in water, and then adding the cross-linking agent to form a wall material mother solution;

[0031] S3, preparing core material mother solution;

[0032] S4, spray drying the wall material mother solution onto the core material mother solution by three-fluid spraying to achieve encapsulation and obtain the microcapsule composition;

[0033] S5. Add the rheological suspending agent to part of the water at 60-80°C, dissolve and swell, and cool to obtain a rheological suspending agent system; add the solubilizing agent to part of the water and dissolve it at 50-60°C, stir and mix evenly, slowly add it to the rheological suspending agent system, disperse and dissolve while stirring, and after complete dispersion, cool to 40-50°C, add the moisturizer, chelating agent, flavor, preservative, microcapsule composition and remaining ingredients in turn, stir evenly, then add the pH adjuster and remaining ingredients, adjust the pH to obtain a mouthwash composition with long-lasting antibacterial effect.

[0034] Furthermore, in step S1, the reaction temperature is 20-60°C.

[0035] The present invention has the following beneficial effects:

[0036] 1. The microcapsule composition with a core-shell structure added to the mouthwash composition of the present invention can effectively and stably release the drug, prolong the residual time of the drug in the oral cavity, and achieve a lasting antibacterial effect; firstly, the wall material of the microcapsule composition contains cationized polyvinyl alcohol obtained by the reaction of glycidyl trimethylammonium chloride and polyvinyl alcohol. Since the cationized polyvinyl alcohol contains a large number of cationic groups, when it is compounded with starch and other ingredients to prepare the wall material, the wall material can have a good hydrophilic effect.

[0037] 2. Cationized polyvinyl alcohol provides a large number of hydrophilic groups such as hydroxyl groups, which can further improve the hydrophilicity of the wall material, making the microcapsule composition more compatible with the inside of the oral cavity, helping the microcapsules to moisten in the oral cavity, strengthening the interaction with oral tissues, and better adsorbing on the gums and buccal mucosa; moreover, the cell wall components of bacteria in the oral cavity have negatively charged groups, and the metabolites produced by the bacteria themselves make them negatively charged, and the cationic polyvinyl alcohol can adsorb the negatively charged bacteria on the surface from the oral cavity, and play a synergistic oral antibacterial effect with the functional substances in the core material, inhibiting and killing bacteria, preventing the formation of biofilm, and thus improving the antibacterial effect of the mouthwash.

[0038] 3. The present invention adopts three-fluid encapsulation technology. The core-shell structure of the core material and the wall material can effectively encapsulate the functional substance, protect the functional substance from being affected by the environment in the mouthwash, and make the functional substance have better stability.

[0039] 4. The microcapsule composition has excellent responsiveness to the human oral environment. Since the starch in the wall material is gradually decomposed by salivary amylase in the mouth, the functional substances in the microcapsule composition can be slowly released, effectively improving the problem of sudden release of the functional substances in the oral cavity, so as to achieve the purpose of sustained release of the functional substances and effectively improve the long-term antibacterial effect of the mouthwash. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] Figure 1 Schematic diagram of three-fluid nozzle spray drying. DETAILED DESCRIPTION

[0041] In order to more clearly illustrate the technical solution of the present invention, the following examples and comparative examples are listed. Unless otherwise stated, the raw materials, reactions and post-treatment methods in the examples and comparative examples are common raw materials on the market and technical methods well known to those skilled in the art.

[0042] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0043] Unless otherwise stated, all formulations and testing herein took place at room temperature.

[0044] Herein, "includes", "comprising", "including", "containing", "having" or other variations are intended to cover non-exclusive inclusions, and no distinction is made between these terms. The term "comprising" means that other steps and ingredients that do not affect the end result can be added. The term "comprising" also includes the terms "consisting of" and "consisting essentially of". The compositions and methods / processes of the present invention may include, consist of, and consist essentially of the essential elements and limitations described herein, as well as any additional or optional ingredients, components, steps, or limitations described herein.

[0045] Terms and Definitions:

[0046] Three-fluid encapsulation technology:

[0047] The principle of ordinary spray drying technology is to use air that is filtered and heated to enter the air distributor at the top of the dryer. The hot air enters the drying chamber evenly in a spiral shape. The liquid passes through the high-speed centrifugal atomizer at the top of the tower body and (rotates) sprays into extremely fine mist droplets, which are in contact with the hot air in parallel and dried into micro-nano powder products in a very short time. Compared with ordinary spray drying technology, three-fluid nozzle spray drying (such as Figure 1 As shown in the figure, the core material and the wall material are effectively separated, so that the wall material can effectively wrap the core material, thereby improving the wrapping efficiency.

[0048] Drug microcapsule embedding rate: refers to the ratio of the mass of the drug encapsulated by the wall material to the total mass of the drug, which is calculated by the following formula:

[0049] Accurately weigh an appropriate amount of drug microcapsule product, recorded as M, extract with a certain volume of solvent for about 2 minutes, filter, and further extract with 2 times the volume of solvent, filter, collect the two filtrates, put them into a rotary evaporator for rotary evaporation until the solvent is completely removed, and its mass is recorded as m. The embedding rate of drug microcapsules (%) = (1-m / M) × 100%.

[0050] Drug microcapsule particle size:

[0051] The size of drug microcapsules is an important factor affecting the antibacterial effect of drug microcapsules. The smaller the particle size of the microcapsules, the larger the specific surface area, and the easier it is to attach to the gums and oral mucosa; but due to the limited gap between teeth, a too small size will affect its residue in the oral cavity. At the same time, the larger the particle size of the microcapsules, the more it will affect its attachment to the gums, mucosa and other locations in the oral cavity; and if the particle size is too large, the drug microcapsules will have a peculiar smell in the oral cavity, the taste will deteriorate, and it will also seriously affect the stability of the drug microcapsules in the matrix. The particle size of the drug microcapsules in the present invention is analyzed and tested accordingly using a laser particle size analyzer, using D50, that is, the particle size corresponding to the cumulative particle size distribution percentage of the sample reaching 50%. The size of the drug microcapsules D50 in the present invention is 1-100μm, preferably 5-50μm.

[0052] Sustained release amount of drug microcapsules:

[0053] To simulate the oral environment, add amylase to the aqueous solution and adjust the pH value of the aqueous solution to control the response factor of the drug microcapsule. Use the UV spectrophotometer to scan the full UV band of drugs of different concentrations under different response conditions, and develop a standard curve. Then detect the absorbance of the drug in the release solution and calculate its concentration through the standard curve, and then calculate the cumulative release of the drug according to the following formula.

[0054]

[0055] in:

[0056] Rn: cumulative drug release at the nth hour;

[0057] 100: volume of the solution (mL);

[0058] Cn: drug concentration of solution at the nth hour (mg / mL);

[0059] 1000: conversion unit (μg / mg);

[0060] m: drug microcapsule powder mass (mg);

[0061] ω: encapsulation rate of drug microcapsules.

[0062] Mouthwash oral antibacterial test:

[0063] The uniqueness of the oral cavity lies in the diversity of microorganisms, with up to 1,000 different types of microorganisms. Different people have different eating habits, oral care habits, and physical immunity, which leads to certain differences in the oral environment between different people. For the complex oral environment, in order to verify the effective antibacterial effect of mouthwash, the actual use of mouthwash by the testers, and then the changes in the number of aerobic and anaerobic bacteria in the mouths of different testers after a period of time after using mouthwash, can directly reflect the antibacterial effect of different drugs on the actual oral cavity. Five volunteers were selected, and each used a mouthwash. Weigh about 10ml of mouthwash, according to each person's mouthwashing habits, clean the oral food residue with 100ml of clean water before rinsing, and then use mouthwash for 30s. Saliva samples were taken before rinsing, 2h, 5h, and 8h after rinsing, and 1g of saliva was spit out each time for subsequent bacterial culture experiments, and the number of aerobic and anaerobic bacteria was calculated according to the following formula.

[0064]

[0065] S h and S y are the number of aerobic and anaerobic bacteria in the oral cavity before using mouthwash, S h1 and S y1 They are the number of aerobic bacteria and anaerobic bacteria in the oral cavity after using mouthwash for a period of time.

[0066] The mass fractions and mass fractions of the components described in the preparation method of the present invention can be converted: if the mass fraction of the core material is known to be 3g, then the mass fraction of the cationized polyvinyl alcohol (mass fraction is 5%) is 0.15g, and so on.

[0067] Glycerin, sorbitol, n-butanol, solvent.

[0068] Polyglycerol-10 caprylate, solubilizer, was purchased from Foshan Yinmei United Technology Co., Ltd.

[0069] PEG-40 hydrogenated castor oil, solubilizer, purchased from BASF (China) Co., Ltd.

[0070] Gellan gum was purchased from CP Kelco (Shandong) Biological Products Co., Ltd.

[0071] Citric acid, pH adjuster.

[0072] Fructo-oligosaccharide was purchased from Shanghai MacLean Biochemical Technology Co., Ltd.

[0073] Potato starch, pharmaceutical grade, was purchased from Shanghai MacLean Biochemical Technology Co., Ltd.

[0074] Calcium chloride crosslinker and electrolyte were purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0075] Ethyl cellulose, the carrier of the active ingredient, was purchased from Shanghai MacLean Biochemical Technology Co., Ltd.

[0076] Stearic acid, a sustained-release enhancer for effective substances, was purchased from Shanghai MacLean Biochemical Technology Co., Ltd.

[0077] Polyvinyl alcohol (PVA), analytical grade, was purchased from MacLean Chemical Reagent Co., Ltd., with an average degree of polymerization of about 1700.

[0078] Glycidyl trimethylammonium chloride, GTMAC, was purchased from Shanghai Haohong Biopharmaceutical Technology Co., Ltd.

[0079] Menthol, taste enhancer.

[0080] The components and corresponding mass fractions of the mouthwash compositions with long-lasting antibacterial efficacy of Examples 1-3 of the present invention are shown in Table 1.

[0081] Table 1 Components and mass fractions of the mouthwash compositions with long-lasting antibacterial effects of Examples 1-3

[0082]

[0083]

[0084] Table 2 shows the components of the microcapsule compositions of Examples 1-3, wherein the mass ratio of the wall material to the core material in the examples is 1;

[0085] Table 2 Components and mass fractions of the microcapsule compositions of Examples 1-3

[0086]

[0087]

[0088] The preparation method of the mouthwash composition with long-lasting antibacterial effect of Examples 1-3 comprises the following steps:

[0089] S1. Under ultrasonic conditions, glycidyl trimethylammonium chloride was slowly added to a 0.1 g / mL aqueous solution of polyvinyl alcohol (1:5, m / m), the pH was adjusted to 9 with an aqueous potassium hydroxide solution, and the reaction was carried out at 35° C. for 1.5 h. After the reaction was completed, the pH was adjusted to 7 with dilute hydrochloric acid, and the cationic polyvinyl alcohol was obtained after drying;

[0090] S2. According to the above mass fractions, the components of the wall material except the electrolyte are placed in 300 parts of deionized water, mixed at 90°C for 1 hour, then cooled to 70°C, and then the electrolyte is added and mixed evenly in pure water to form a wall material mother solution;

[0091] S3, preparing core material mother solution;

[0092] According to the above mass fractions, the components in the core material are placed in 100 parts of ethyl acetate, sealed and mixed and stirred at 75°C for 30 minutes to form a core material mother solution;

[0093] S4, spray drying the wall material mother liquid onto the core material mother liquid by three-fluid spraying, spraying the three-fluid from two nozzles to achieve spray drying of the core material and wrapping of the core material by the wall material, controlling the temperature at the nozzle of the three-fluid spray dryer to 90° C., and obtaining a microcapsule composition;

[0094] Wherein, the mass ratio of the core material to the wall material is 1:3;

[0095] S5. According to the above mass fraction, add the rheological suspending agent to 1 / 3 of deionized water at 70°C, dissolve and swell, and cool to obtain a rheological suspending agent system; add the solubilizer to 1 / 3 of deionized water and dissolve it at 50°C, stir and mix evenly, slowly add it to the rheological suspending agent system, disperse and dissolve while stirring, after complete dispersion, cool to 40°C, add the moisturizer, chelating agent, flavor, preservative, and microcapsule composition in turn, stir evenly, then add the pH adjuster and the remaining ingredients, adjust the pH to 6, and obtain a mouthwash composition with long-lasting antibacterial effect.

[0096] Comparative Example 1

[0097] A mouthwash composition. The difference between this comparative example and Example 1 is that the starch in the wall material is removed in this comparative example, and the other components and preparation methods are the same.

[0098] Comparative Example 2

[0099] A mouthwash composition. The difference between this comparative example and Example 1 is that: this comparative example removes steps S1-S4, that is, removes the wall material in the microcapsule composition, so that the functional substance and the functional substance sustained-release enhancer are physically mixed with other ingredients in a mass ratio of 1:5, and the other components and preparation methods are the same.

[0100] Comparative Example 3

[0101] A mouthwash composition, the difference between this comparative example and Example 1 is that: in this comparative example, step S1 is removed, and the mass of cationized polyvinyl alcohol is replaced by polyvinyl alcohol (purchased from Sigma, 363170), and the other components and preparation methods are the same.

[0102] Test Example 1

[0103] The mouthwash compositions of Examples 1-3 and Comparative Examples 1-3 were tested for performance of embedding rate, microcapsule particle size, and sustained release amount. The test results are shown in Table 3.

[0104] Table 3 Performance test results of mouthwash compositions of Examples 1-3 and Comparative Examples 1-3

[0105]

[0106] As can be seen from Table 3, the mouthwash of the present invention has an excellent antibacterial effect compared with the mouthwash of Comparative Examples 1-3, and the sustained release can last up to 8h, greatly extending the antibacterial effect time of the mouthwash for aerobic and anaerobic bacteria. In Comparative Example 1, due to the removal of the starch in the wall material, it is impossible to work with cationized polyvinyl alcohol, and the environmental response in the amylase or oral environment makes it impossible to release the efficacy drug, and only the free drug acts, and it is impossible to achieve long-term antibacterial. At the same time, in Comparative Example 2, the efficacy drug is not wrapped, and the efficacy drug cetylpyridinium chloride is instantly dissolved in the matrix at the moment of adding to the mouthwash, similar to cetylpyridinium chloride directly added to the mouthwash, and it is also impossible to achieve long-term release and long-term antibacterial. At the same time, it is also explained that the preparation method of the drug microcapsule of this patent can effectively achieve the sustained release of the efficacy substance and realize the long-term antibacterial of the mouthwash. Moreover, by adopting the encapsulation method of the microcapsule of the three-fluid, the encapsulation rate of the microcapsule can reach more than 70%, effectively realizing the high encapsulation rate of the microcapsule composition. At the same time, by adopting the three-fluid spray drying method, the particle size D50 of the drug microcapsules is distributed between 20-40 μm, and has an excellent sustained-release effect; while in Comparative Example 3, the antibacterial effect of the mouthwash is significantly reduced due to the replacement of cationic polyvinyl alcohol with polyvinyl alcohol.

[0107] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

[0108] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A mouthwash composition with long-lasting antibacterial effect, characterized in that: The mouthwash composition with long-lasting antibacterial effect comprises the following components in mass fraction: Wherein, the microcapsule composition comprises a wall material and a core material, and the wall material comprises a cationized polyvinyl alcohol, starch, a cross-linking agent and an electrolyte; The cationized polyvinyl alcohol is obtained by the reaction of glycidyl trimethylammonium chloride and polyvinyl alcohol; The core material comprises an efficacy substance, an efficacy substance sustained-release enhancer and an efficacy substance carrier.

2. The mouthwash composition with long-lasting antibacterial effect according to claim 1, characterized in that: The mass ratio of the core material to the wall material is 1:10-10:

1.

3. The mouthwash composition with long-lasting antibacterial effect according to claim 1, characterized in that: The starch is selected from one or more of corn starch, potato starch, sweet potato starch, rice starch, and millet starch; The cross-linking agent is selected from one or more of gellan gum, locust bean gum, gelatin and carrageenan; The electrolyte is selected from one or more of inorganic salts and / or organic salts.

4. The mouthwash composition with long-lasting antibacterial effect according to claim 1, characterized in that: The functional substance is selected from one or more of honeysuckle extract, white peony extract, bitter almond extract, dipotassium glycyrrhizinate, zinc lactate, eugenol, tannic acid, cymene, chlorhexidine, cetylpyridinium chloride and triclosan.

5. The mouthwash composition with long-lasting antibacterial effect according to claim 1, characterized in that: The functional substance carrier is selected from one or more of cellulose, dextrin or polysaccharide; The efficacy substance sustained-release enhancer is selected from one or more of fatty acids or fatty alcohols.

6. The mouthwash composition with long-lasting antibacterial effect according to claim 1, characterized in that: The particle size of the microcapsule composition is 1-100 μm.

7. The mouthwash composition with long-lasting antibacterial effect according to claim 1, characterized in that: The solvent is selected from one or more of glycerol, propylene glycol, butylene glycol, sorbitol, mannitol, and polyglycerol; The solubilizing agent is selected from one or more of polyoxyethylene hydrogenated castor oil and polyglycerol ester surfactants; The rheological suspending agent is selected from one or more of xanthan gum, carrageenan, locust bean gum, gellan gum, guar gum and konjac gum; The auxiliary agent is selected from one or more of a moisturizer, a taste regulator, a pH regulator, a chelating agent, a flavor, a preservative, an amino acid, and a pigment.

8. A method for preparing a mouthwash composition having a long-lasting antibacterial effect according to any one of claims 1 to 7, characterized in that: The steps include: S1. Under ultrasonic conditions, slowly add glycidyl trimethylammonium chloride to an aqueous solution of polyvinyl alcohol, adjust the pH to 8-10, and react for 1-4 hours. After the reaction is completed, cool to room temperature, adjust the pH to 7-8, and dry to obtain cationic polyvinyl alcohol; S2, mixing the components of the wall material except the cross-linking agent in water, and then adding the cross-linking agent to form a wall material mother solution; S3, preparing core material mother solution; S4, spray drying the wall material mother solution onto the core material mother solution by three-fluid spraying to achieve encapsulation and obtain a microcapsule composition; S5. Add the rheological suspending agent to part of the water at 60-80°C, dissolve and swell, and cool to obtain a rheological suspending agent system; add the solubilizing agent to part of the water and dissolve it at 50-60°C, stir and mix evenly, slowly add it to the rheological suspending agent system, disperse and dissolve while stirring, and after complete dispersion, cool to 40-50°C, add the moisturizer, chelating agent, flavor, preservative, and microcapsule composition in turn, stir evenly, then add the pH adjuster and the remaining ingredients, adjust the pH, and obtain a mouthwash composition with long-lasting antibacterial effect.

9. The method for preparing the mouthwash composition with long-lasting antibacterial effect according to claim 8, characterized in that: In step S1, the reaction temperature is 20-60°C.

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