Calibration device for a super high dose rate radiation device, calibration method and super high dose rate radiation device

Abstract

The present disclosure provides a calibration device for a super high dose rate radiation device comprising a plurality of beam modules for emitting a plurality of radiation beamlets, the calibration device comprising: a calibration target assembly comprising a target portion, wherein the target portion is located at a predetermined radiation region of the super high dose rate radiation device during a calibration process; wherein the target portion is used as a reference to calibrate a convergence deviation of the plurality of radiation beamlets converging at the predetermined radiation region. A calibration method and a super high dose rate radiation device are also provided.

Description

TECHNICAL FIELD

[0001] The present disclosure relates to the field of radiotherapy, in particular to the field of FLASH therapy, and more particularly to a calibration device for a super high dose rate radiation device, a calibration method and a super high dose rate radiation device. BACKGROUND

[0002] Super high dose rate includes a dose rate of 40 Gy / s or more in a short time, for example, an average dose rate of 300 Gy / s or more, which can be applied to medical radiotherapy, container security inspection and industrial imaging fields.

[0003] Taking FLASH therapy as an example, it is also called super high dose rate radiotherapy (abbreviation: FLASH-RT), which is a treatment plan for tumor radiotherapy. By using FLASH therapy technology, not only the normal tissue has lower toxic and side effects when killing tumor cells, but also the risk of damage to the patient's body due to taking a large amount of rejection drugs after surgery is reduced, and the recovery period after surgery is shortened and the quality of life after surgery is improved.

[0004] In the process of implementing the concept of the present disclosure, the inventors found that how to perform multi-angle super high dose rate radiation on a specified position in a short time (such as a few hundred milliseconds) is a problem to be solved at present. SUMMARY

[0005] In view of the above problems, the present disclosure provides a calibration device for a super high dose rate radiation device, a calibration method and a super high dose rate radiation device.

[0006] According to a first aspect of the present disclosure, a calibration device for a super high dose rate radiation device is provided, the super high dose rate radiation device comprising a plurality of beam modules for emitting a plurality of radiation beam flows, the calibration device comprising: a calibration target assembly comprising a target portion, wherein the target portion is located in a predetermined radiation region of the super high dose rate radiation device during calibration; and wherein the target portion is used as a reference to calibrate intersection deviation of the plurality of radiation beam flows intersecting at the predetermined radiation region.

[0007] In some embodiments, the plurality of beam modules are mounted on a rotating drum of the super high dose rate radiation device, and the target portion being located in the predetermined radiation region of the super high dose rate radiation device during calibration comprises: during calibration, a center of the target portion is located on a rotation axis of the rotating drum.

[0008] In some embodiments, the calibration device further comprises: a plurality of laser assemblies, each of which is installed at a corresponding beam emission position of each of the plurality of beam modules; and wherein the plurality of laser assemblies are used to emit a plurality of laser beams to the target portion to simulate intersection positions of the plurality of radiation beam flows intersecting at the predetermined radiation region.

[0009] In some embodiments, the target portion comprises a sphere, wherein a sphere center of the sphere is located on a rotation axis of the rotation drum during the calibration process.

[0010] In some embodiments, the sphere is drawn with interwoven meridians and parallels, wherein the meridians and parallels are used to characterize the intersection deviation between any two of the multiple laser beams.

[0011] In some embodiments, the multiple beam modules are annularly distributed around the rotation drum, and the sphere is used as a reference to guide the multiple laser beams to intersect on the sphere surface.

[0012] In some embodiments, a radius of the sphere is less than or equal to a predetermined threshold, and a sphere center of the sphere coincides with a target point position in the predetermined radiation region, wherein the predetermined threshold is used to constrain an error between a hitting position of any one of the laser beams and the target radiotherapy position.

[0013] In some embodiments, the calibration target assembly further comprises a support frame, the support frame comprising: a base mounted to an inner wall of the rotation drum, a bottom surface of the base having a curvature matching a curvature of a mounting area of the inner wall of the rotation drum; and a connecting member having a first end connected to the base and a second end connected to the sphere.

[0014] In some embodiments, a distance between each of the beam emission positions of the multiple beam modules and the target portion is substantially equal.

[0015] In some embodiments, the target portion comprises at least one dose detection module configured to detect a first actual dose of the radiation beam emitted by each of the beam modules, wherein a difference between the first actual dose and a first theoretical dose of the radiation beam emitted by each of the beam modules is used to characterize the intersection deviation.

[0016] In some embodiments, the at least one dose detection module comprises at least one dosimeter configured to detect the first actual dose of the radiation beam emitted by each of the beam modules.

[0017] In some embodiments, the at least one dosimeter comprises a plurality of dosimeters, the multiple beam modules are annularly distributed around the rotation drum of the ultra-high dose rate radiation device, and a plurality of radiation detection areas of the plurality of dosimeters are annularly distributed to correspond one-to-one to a plurality of beam emission positions of the multiple beam modules, wherein the plurality of dosimeters are configured to detect the first actual dose of each of the multiple radiation beams one-to-one.

[0018] In some embodiments, the at least one dose detection module comprises at least one ionization chamber for detecting a second actual dose of the radiation beam emitted by each beam module; wherein a difference between the second actual dose and a first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

[0019] In some embodiments, the at least one ionization chamber comprises a plurality of ionization chambers, the plurality of beam modules are annularly distributed around a rotating drum of the ultra-high dose rate radiation device, and a plurality of radiation incidence angles of the plurality of ionization chambers correspond one-to-one to a plurality of beam emission positions of the plurality of beam modules to one-to-one receive the plurality of radiation beams; wherein the plurality of ionization chambers are used to one-to-one detect a second actual dose of each radiation beam in the plurality of radiation beams.

[0020] Another aspect of the embodiments of the present disclosure provides a calibration method for an ultra-high dose rate radiation device, the ultra-high dose rate radiation device comprising a plurality of beam modules for emitting a plurality of radiation beams, the calibration method comprising: in a calibration process, arranging a target of a calibration target assembly in a predetermined radiation region of the ultra-high dose rate radiation device; and using the target as a reference to calibrate an intersection deviation of the plurality of radiation beams intersecting at the predetermined radiation region.

[0021] Another aspect of the embodiments of the present disclosure provides an ultra-high dose rate radiation device, comprising: a rotating drum; a plurality of beam modules for emitting a plurality of radiation beams, wherein the plurality of beam modules are annularly distributed around the rotating drum; and wherein the plurality of beam modules are configured to be calibrated by the calibration device according to any one of the preceding embodiments to intersect the plurality of radiation beams at a predetermined radiation region.

[0022] The one or more embodiments described above have the following beneficial effects: a calibration target assembly is provided, and a target thereof is used as a reference to calibrate an intersection deviation of the plurality of radiation beams intersecting at the predetermined radiation region, so that the plurality of radiation beams can intersect at the predetermined radiation region, and the intersection deviation meets the expected requirements. The calibrated plurality of beam modules can perform ultra-high dose rate radiation on the same specified position at multiple angles. BRIEF DESCRIPTION OF DRAWINGS

[0023] The above and other objects, features and advantages of the present disclosure will become more apparent from the following description when taken in conjunction with the accompanying drawings, in which:

[0024] Figure 1 A partial structural diagram of an ultra-high dose rate radiation device according to an embodiment of the present disclosure is schematically shown;

[0025] Figure 2 A structural diagram of a calibration target assembly according to an embodiment of the present disclosure is schematically shown, wherein,Figure 2 (a) is a front view of the calibration target assembly, Figure 2 (b) is a side view of the calibration target assembly;

[0026] Figure 3 schematically shows a structural cross-sectional view of the rotary drum and the calibration target assembly according to an embodiment of the present disclosure;

[0027] Figure 4 schematically shows a structural top view of the rotary drum and the calibration target assembly according to an embodiment of the present disclosure;

[0028] Figure 5 schematically shows an installation zero position state diagram according to an embodiment of the present disclosure;

[0029] Figure 6 schematically shows a flow chart of a calibration method according to an embodiment of the present disclosure.

[0030] The reference signs involved in the above-mentioned drawings include:

[0031] 100, a super high dose rate radiation device; 110, a beam assembly; 111, a first beam module; 112, a second beam module; 113, a third beam module; 114, a fourth beam module; 115, a fifth beam module; 120, a rotary drum; 130, a calibration target assembly; 131, a sphere; 132, a base; 133, a connecting piece; 140, an installation support; 141, a first support; 142, a second support; 510, a slot; 520, a positioning jackscrew.

[0032] It should be noted that, for the sake of clarity, the size of the whole / partial structure or the whole / partial region may be enlarged or reduced in the drawings used for describing the embodiments of the present disclosure, i.e., these drawings are not drawn according to the actual scale. DETAILED DESCRIPTION

[0033] Hereinafter, embodiments of the present disclosure will be described with reference to the accompanying drawings. However, it should be understood that these descriptions are merely exemplary and are not intended to limit the scope of the present disclosure. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the embodiments of the present disclosure. However, it will be apparent to those skilled in the art that one or more embodiments can be practiced without these specific details. In addition, in the following description, descriptions of well-known structures and techniques have been omitted to avoid unnecessarily obscuring the concept of the present disclosure.

[0034] Figure 1 schematically shows a partial structural view of a super high dose rate radiation device 100 according to an embodiment of the present disclosure. Figure 2 schematically shows a structural view of a calibration target assembly 130 according to an embodiment of the present disclosure. Wherein, Figure 2(a) is a front view of the calibration target assembly 130. Figure 2 (b) is a side view of the calibration target assembly 130.

[0035] like Figure 1 As shown, the ultra-high dose rate radiation device 100 includes a beam assembly 110, a rotating drum 120, and a mounting bracket 140. The beam assembly 110 may include multiple beam modules for emitting multiple radiation beams, such as a first beam module 111, a second beam module 112, a third beam module 113, a fourth beam module 114, and a fifth beam module 115. The mounting bracket 140 may include a first bracket 141 and a second bracket 142. The first beam module 111, the second beam module 112, and the third beam module 113 may be mounted on the first bracket 141, and the fourth beam module 114 and the fifth beam module 115 may be mounted on the second bracket 142.

[0036] For example, the ultra-high dose rate radiation device 100 disclosed herein is used to generate a radiation beam applicable to fields such as radiotherapy, container security inspection and industrial imaging, and can achieve radiation transfer at ultra-high dose rates (e.g., above 40 Gy / s), thereby completing the desired radiation in a very short time.

[0037] Figure 1 The schematic location of the calibration device is shown, which may be located within the rotary drum 120. In some embodiments, the calibration device includes a calibration target assembly 130. The calibration target assembly 130 includes a target portion located within a predetermined radiation region of the ultra-high dose rate radiation device 100 during calibration; wherein the target portion is used as a reference to calibrate the convergence deviation of multiple radiation beams converging in the predetermined radiation region.

[0038] For example, the beam module may include a linear accelerator. The radiation beam may include an X-ray beam. The predetermined radiation area may be an area within the ultra-high dose rate radiation device 100 that allows for radiotherapy, such as a space within the rotary drum 120 that can accommodate the target object to be radiotherapy. The predetermined radiation area may be a fixed area within the space, such as where the lesion of the patient being radiotherapy is placed before receiving radiotherapy.

[0039] In some embodiments, the ultra-high dose rate radiation device 100 may include one or more predetermined radiation zones. In the case where the ultra-high dose rate radiation device 100 includes multiple predetermined radiation zones, multiple calibration devices may be provided to provide calibration functions simultaneously or asynchronously, or a single calibration device may be provided to provide calibration functions by changing its position among multiple predetermined radiation zones.

[0040] In some embodiments, the distance between each of the beam modules and the target portion is substantially equal. This is advantageous for achieving a substantially uniform radiation effect on the treatment area by each of the beam modules, and for the accuracy of calibration.

[0041] In an example, the rotating drum 120 can rotate around its rotation axis, and in turn rotate the first beam module 111, the second beam module 112, the third beam module 113, the fourth beam module 114, and the fifth beam module 115. For example, in a calibration process, the center of the target portion is located at the rotation axis of the rotating drum 120. Thus, during rotation, the rotating drum 120 can rotate around the predetermined radiation area, and during rotation, by switching different beam modules, the same predetermined radiation area (e.g., a lesion) can be radiated at different angles, where each beam module can achieve the effect of ultra-high dose rate radiation. The multiple beam modules can be switched in a sequence and relative to the predetermined radiation area, or the sequence can be changed. If necessary, the multiple beam modules can also be switched simultaneously for treatment.

[0042] By arranging multiple beam modules (e.g., acceleration tubes or X-ray tubes or other radiation generating devices) at different angles on a rotatable rotating drum 120, and by switching the beam modules to generate radiation, the purpose of quickly performing multiple angle irradiation treatment in a very short time in flash radiotherapy can be achieved. That is, after calibration, by cooperation of the rotating drum 120 and the multiple beam modules, ultra-high dose rate irradiation at multiple angles on the predetermined radiation area can be achieved.

[0043] In this case, the target portion as a reference means that the target portion can be hit by the simulated radiation beam or the actual radiation beam, and the target portion can be used as a reference to guide the simulated radiation beam or the actual radiation beam to hit the predetermined radiation area.

[0044] Whether the target portion is hit by the simulated radiation beam or the actual radiation beam, the intersection of the multiple radiation beams at the predetermined radiation area can be represented by visual or non-visual methods. Non-visual methods can include signal detection or dose detection data processing methods. By visual or non-visual representation, the intersection deviation of the multiple radiation beams at the predetermined radiation area can be calibrated. The intersection deviation includes the distance between the hit position of any radiation beam at the predetermined radiation area and a specific position, or the distance between the hit positions of any two radiation beams at the predetermined radiation area.

[0045] In some embodiments, the target portion is used as a reference to calibrate the intersection deviation of the multiple beam modules at the predetermined radiation area, including at least one of the following:

[0046] The multiple beam modules are simulated to emit beams, and the multiple beam radiation beams are simulated to hit the target part. The hitting positions and intersection deviations of the multiple beam visible lights are tested manually or recognized by images according to a visual method.

[0047] The multiple beam modules are actually emitted, and the doses of the radiation beams in the predetermined radiation region are detected by a dose detection method. The intersection deviations are calibrated according to the differences between the doses of the radiation beams.

[0048] The multiple beam modules are actually emitted, and the radiation signals of the radiation beams in the predetermined radiation region are detected by a radiation signal detection method. The intersection deviations are calibrated according to the radiation energy, the number of rays, or the representation of the radiation scanning image.

[0049] It can be understood that the above-mentioned simulation of the emission of the multiple beam modules, the dose detection method, and the radiation signal detection method can be used alternatively or sequentially.

[0050] According to an embodiment of the present disclosure, a calibration target assembly 130 is provided, which uses the target part as a reference to calibrate the intersection deviations of the multiple beam radiation beams intersecting in the predetermined radiation region, so that the multiple beam radiation beams can intersect in the predetermined radiation region, and the intersection deviations meet the expected requirements. The calibrated multiple beam modules can perform ultra-high dose rate radiation on the same specified position at multiple angles.

[0051] The following further describes embodiments in which the target part is used as a reference to calibrate the intersection deviations of the multiple beam modules intersecting in the predetermined radiation region.

[0052] In some embodiments, the calibration device further comprises a plurality of laser assemblies. The plurality of laser assemblies are installed one by one at the beam emission positions of the multiple beam modules respectively; wherein the plurality of laser assemblies are used to emit multiple laser beams to the target part to simulate the intersection positions of the multiple beam radiation beams intersecting in the predetermined radiation region.

[0053] Each laser assembly is installed at the beam emission position of the corresponding beam module, and the installation axis coincides with the beam axis of the corresponding beam module for adjustment and positioning during installation. After calibration is completed, the laser assembly can be removed.

[0054] For example, the intersection position includes a region where the multiple laser beams converge at the target part, and the region includes one or more points hit by each laser beam. The intersection deviations between the multiple laser beams can be reflected by the distances between the points of the laser beams or the distances between the points of each laser beam and the target point. When the intersection deviations do not meet the requirements, one or more of the angle, the height, the position, the collimation parameter, and the like of the beam module can be adjusted, and then the multiple laser assemblies are used to emit multiple laser beams to the target part again.

[0055] According to an embodiment of the present disclosure, by providing a laser assembly to simulate the emission of a multi-beam radiation beam, the intersection deviation can be efficiently measured in a small cost and visualized manner, and it can be quickly found whether the intersection position meets the conditions, and then it is determined whether to adjust the beam module.

[0056] Exemplarily, the target part can include a plane mirror, a multi-faceted mirror, a flat plate, a cube, or a sphere, and the like, which can display the hitting points of each laser beam in a visualized manner.

[0057] For example, in the case where the target part includes a single plane mirror or a flat plate, target points can be marked thereon, the first beam module 111 corresponding laser assembly is first moved to a specific position to emit laser to the target part, and the position of the hitting point is recorded. Then, through the rotation of the rotating drum 120, the remaining each beam module is sequentially moved to the same position, and the corresponding laser assembly is caused to emit laser, and the position of the hitting point is recorded. After obtaining the hitting point positions of all laser assemblies, the distances between each hitting point and the target point, and the distances between the hitting points can be calculated.

[0058] For example, in the case where the target part includes a multi-faceted mirror, it can include a prism structure formed by a plurality of plane mirror facets. The plurality of laser assemblies are caused to emit laser to the multi-faceted mirror at the same time to simulate the simultaneous emission of the plurality of beam modules. The intersection deviation is measured by the hitting points of each laser beam presented by the multi-faceted mirror.

[0059] For example, in the case where the target part includes a cube, it can be a square, a cuboid, or other polyhedrons, etc. The plurality of laser assemblies are caused to emit laser to the cube at the same time to simulate the simultaneous emission of the plurality of beam modules. The intersection deviation is measured by the hitting points of each laser beam presented by the cube.

[0060] For example, in the case where the target part includes a sphere 131, it is further described below.

[0061] In some embodiments, the center of the sphere 131 is located on the rotation axis of the rotating drum 120 during the calibration process.

[0062] The rotating drum 120 can rotate around its rotation axis, and can rotate around the predetermined radiation region during the rotation. Ideally, the rotating drum 120 always rotates around the same treatment center, and the plurality of beam modules are not calibrated again during this process. The same treatment center can be the center position of the predetermined radiation region, which is simulated by the center of the sphere. The sphere 131 can occupy part or all of the predetermined radiation region.

[0063] According to an embodiment of the present disclosure, by locating the center of the sphere on the rotation axis, the actual radiotherapy scene can be simulated, the calibration accuracy can be improved, the data deviation can be reduced, and the accuracy and consistency of the calibration process and the actual radiotherapy process are maintained.

[0064] In some embodiments, the sphere 131 is drawn with interlaced meridians and parallels, where the meridians and parallels are used to characterize intersection deviations between any two of the plurality of laser beams.

[0065] The meridians and parallels on the sphere 131 can serve as a reference grid for detecting and adjusting the alignment of the laser beams. For example, if two laser beams are supposed to intersect at a point on the sphere 131, but actually show on the grid that they intersect at different points, this deviation can be corrected by adjusting the position or angle of the laser emitters.

[0066] According to embodiments of the present disclosure, the meridians and parallels provide a visual framework for accurately measuring intersection deviations of the laser beams and visually simulating the intersection positions.

[0067] In some embodiments, as shown in FIG. 1, the plurality of beam modules are distributed annularly around the rotating drum 120, and the sphere 131 is used as a reference to guide the intersection of the plurality of laser beams on the surface of the sphere. Further, the intersection points of the plurality of laser beams on the sphere 131 can be guided to lie on the same circular cross-section. Figure 1 The plurality of beam modules are evenly distributed around the rotating drum 120 and can emit radiation beams from different angles simultaneously or asynchronously. By calibration, the intersection points of all the laser beams on the sphere 131 can be made to lie on the sphere 131, so that the expected intersection positions can be obtained by emitting the plurality of radiation beams during actual radiotherapy. Keeping the intersection points on the same circular cross-section is conducive to achieving close intersection points and thus achieving the effect of flash therapy with ultra-high dose rate.

[0068] In some embodiments, the radius of the sphere 131 is less than or equal to a predetermined threshold, and the center of the sphere 131 coincides with the position of a target point in a predetermined radiation region, where the predetermined threshold is used to constrain the error between the intersection point of any laser beam and the target radiotherapy position.

[0069] By controlling the radius and center of the sphere 131, the irradiation range of the laser beams can be controlled, i.e., when any laser beam can irradiate the sphere 131, the distance between its intersection point and the center of the sphere is equal to the predetermined threshold, so that the error is less than the predetermined error value. In the case where the predetermined threshold is less than or equal to the predetermined error value, it is quickly confirmed in a visual manner which laser beams meet the intersection deviation because they irradiate the sphere 131, and which laser beams do not meet the intersection deviation because they do not irradiate the sphere 131, so that the beam modules corresponding to the laser beams that do not meet the intersection deviation are adjusted.

[0070] For example, the predetermined threshold or the predetermined error value can be determined according to the size of the lesion to be irradiated.

[0071]

[0072] ​Therefore, the ball 131 can be used to realize the beam intersection of multiple beam modules (e.g., multiple linear accelerators) in geometric space, and the intersection error of each radiation beam and the intersection point is less than a predetermined error value (e.g., ±5 mm), so as to realize the irradiation of a specified lesion position with a super-high dose.

[0073] For example, the ball 131 can be made of plastic, iron, lead or stainless steel, and the diameter of the ball 131 can be 10 mm (only an example), the coaxial error between the center of the ball 131 and the rotation axis is less than 0.2 mm, and the machining error is ensured by numerical control machine tool finishing.

[0074] As shown in Figure 2 The calibration target assembly 130 further includes a support frame. The support frame includes a base 132 mounted to the inner wall of the rotating drum 120, the bottom surface of the base 132 has an arc matching the arc of the mounting area of the inner wall of the rotating drum 120, and a connecting piece 133 having a first end connected to the base 132 and a second end connected to the ball 131.

[0075] The bottom surface of the base 132 serves as an assembly mounting surface, which is matched with the curved surface of the inner wall of the rotating drum 120 (i.e., the arcs are matched), so as to be conveniently mounted on the inner circle (inner wall arc surface) of the rotating drum 120. The inner circle mounting position is precisely machined, and the machining error is ensured by numerical control machine tool finishing.

[0076] The following further describes that the actual beams emitted by the multiple beam modules are detected by using the dose detection method to detect the dose of the radiation beams in the predetermined radiation region, and the intersection deviation is calibrated by the difference between the doses of the radiation beams.

[0077] In some embodiments, the target part includes at least one dose detection module for detecting a first actual dose of the radiation beam emitted by each beam module. The difference between the first actual dose and a first theoretical dose of the radiation beam emitted by each beam module is used to represent the intersection deviation.

[0078] It can be understood that when the multiple beam modules can intersect in the predetermined radiation region and the intersection deviation is less than a certain value, the dose of the radiation beam emitted by each beam module in the predetermined radiation region can be determined, which is referred to as the first theoretical dose. Therefore, the difference between the actual detected dose and the theoretical dose can reflect the intersection deviation. For example, it can be determined that there is a certain deviation between the distance between the radiation beam emitted by each beam module and the target point.

[0079] According to the embodiments of the present disclosure, the actual dose and the theoretical dose of the radiation beam emitted by each beam module can be accurately compared, so as to effectively represent the intersection deviation, which can improve the calibration efficiency and reliability, and improve the dose accuracy and consistency of radiotherapy.

[0080] In some embodiments, the at least one dose detection module comprises at least one dosimeter for detecting a first actual dose of the radiation beam emitted by each beam module.

[0081] A dosimeter is a device used to measure the dose of radiation (such as X-rays and gamma rays). For example, it can be based on a radiation-sensitive detector that measures the intensity of radiation, i.e. when a radiation particle in the environment passes through the detector, it reacts with the radiation-sensitive medium, which is then collected by the detector and converted into an electrical signal. The electrical signal is further processed to calculate the dose of radiation.

[0082] For example, the at least one dosimeter can include a single dosimeter with a fixed angle of the radiation detection area, and by rotating each beam module to the same angle through the rotation of the rotating drum 120, the radiation beam is emitted to the radiation detection area of the dosimeter as the target part, and the dose detection of the multi-beam radiation beam is realized.

[0083] In some embodiments, the at least one dosimeter comprises a plurality of dosimeters, and the plurality of beam modules are annularly distributed around the rotating drum 120 of the ultra-high dose rate radiation device 100, and the plurality of radiation detection areas of the plurality of dosimeters are annularly distributed to correspond one-to-one to the plurality of beam emission positions of the plurality of beam modules; wherein the plurality of dosimeters are used to detect the first actual dose of each radiation beam in the multi-beam radiation beam one-to-one.

[0084] For example, the radiation detection area is used to measure the radiation dose that reacts with the radiation passing through the area. The plurality of dosimeters are independent dose detection devices.

[0085] According to the embodiments of the present disclosure, the dose of each beam module can be accurately measured, so that the intersection deviation between each beam module and the target point or other beam modules can be accurately evaluated.

[0086] In some embodiments, the at least one dose detection module comprises at least one ionization chamber for detecting a second actual dose of the radiation beam emitted by each beam module; wherein the difference between the second actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to represent the intersection deviation.

[0087] The ionization chamber contains a chamber filled with inert gas, and there are two electrodes in the chamber. When the radiation is incident, it causes the ionization of the gas in the tube. Under the action of the electric field, the electrons move to the anode, and the positive ions move to the cathode. The electrons collected by the anode form an electric current in the circuit and are recorded, thereby measuring the radiation dose.

[0088] For example, the at least one ionization chamber can include a single ionization chamber, the radiation detection area angle of which is fixed, and each beam module is rotated to the same angle in turn by the rotation of the rotating drum 120, and the radiation beam is emitted to the radiation detection area of the ionization chamber as the target part, so as to realize the dose detection of the multi-beam radiation beam.

[0089] In some embodiments, the at least one ionization chamber includes a plurality of ionization chambers, the plurality of beam modules are distributed around the rotating drum 120 of the ultra-high dose rate radiation device 100 in a ring shape, and the plurality of radiation incidence angles of the plurality of ionization chambers correspond to the plurality of beam emission positions of the plurality of beam modules one by one, so as to receive the plurality of radiation beams one by one; wherein the plurality of ionization chambers are used to detect the second actual dose of each radiation beam in the plurality of radiation beams one by one.

[0090] Figure 3 The structural cross-sectional view of the rotating drum 120 and the calibration target assembly 130 according to the embodiments of the present disclosure is schematically shown. Figure 4 The structural top view of the rotating drum 120 and the calibration target assembly 130 according to the embodiments of the present disclosure is schematically shown. Figure 5 The installation zero position state diagram according to the embodiments of the present disclosure is schematically shown. The installation zero position is the initial state of the installation of the beam module.

[0091] Referring to Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 , the following describes the installation and calibration process of the beam module of the ultra-high dose rate radiation device 100.

[0092] In the case of the installation of the rotating drum 120, the first beam module 111, the second beam module 112 and the third beam module 113 are installed on the first support 141 of the upper part on the working platform, and the fourth beam module 114 and the fifth beam module 115 are installed on the second support 142 of the lower part. The upper beam support is lifted by a lifting tool and is connected with the rotating drum 120 assembly, and is positioned by a fixing pin and is fastened by a screw; then the motor drum is driven to rotate 180°, the lower beam module support is connected with the rotating drum 120 assembly, and is positioned by a fixing pin and is fastened, and then the drum is rotated back to the working zero position.

[0093] Among them, as Figure 5 , the first support 141 and the second support 142 include a slot position 510 for installing the beam module. The installation surface of the first support 141 and the second support 142 is coplanar, and the distance between the surface and the end surface of the drum is controlled to be ≯0.2mm. A plurality of positioning studs 520 are reserved near the slot position 510, which satisfies the four-direction adjustment function of front and back, left and right, which is beneficial to the observation of the positioning reference and the adjustment of the beam module during installation.

[0094] Wherein, in order to facilitate installation and maintenance, the plurality of beam modules are modularly designed, which not only shortens the processing cycle, but also is easy to match with external interface and enhances interchangeability. The first support 141 or the second support 142 is made of aluminum material and is designed as an integrated structure, which reduces the weight as much as possible under the condition of ensuring the support strength and rigidity; the center hole of the acceleration tube mounting flange of the fine beam module is processed, and the tolerance of the center line of the hole to the bottom surface of the installed support 140 is controlled to be ≯0.05mm, so as to ensure the consistency of the beam center line height of each module.

[0095] The calibration target assembly 130 is arranged on the center axis of the rotary drum 120, and the target part of the calibration target assembly 130 includes a spherical body 131. The spherical body 131 is made of stainless steel, and is a circular spherical body 131 with a diameter of 10mm, which is installed on the rotary axis of the rotary drum 120, and the spherical center is coaxial with the rotary axis with an error of ≯0.2mm. The bottom surface of the support frame is curvedly fitted with the inner wall of the rotary drum, and the processing error is ensured by fine processing of a numerical control machine tool. Referring to Figure 3 and Figure 4 The calibration target assembly 130 is adjustable along the front and back directions of the rotary axis of the rotary drum 120, so that the center of the spherical body 131 coincides with the intersection point of the five radiation beams, which can meet the installation and adjustment of the beam modules on site.

[0096] Taking the calibration target assembly 130 as a positioning reference, the position of each beam module is adjusted in sequence by setting the positioning jackscrew 520 of each slot 510 on the first support 141 and the second support 142. After the multiple laser beams are roughly located on the same circular cross section (as much as possible at the spherical center cross section) on the spherical surface irradiated by the front end laser beam of each beam module, the beam module is fastened.

[0097] Wherein, the spherical body 131 is arranged for calibration, and the spherical center is coincided with the rotary axis of the rotary drum 120. The spherical body 131 serves as a reference target of the beam convergence of each beam module, which can be used for multi-directional adjustment and positioning installation of the beam module, and a plurality of beam modules are sequentially installed. Finally, the beam convergence of the arrayed multiple beam modules is realized.

[0098] Based on the calibration equipment for the ultra-high dose rate radiation device 100 as above, a calibration method is also provided, which is described further below.

[0099] Figure 6 A flowchart of the calibration method according to the embodiment of the present disclosure is schematically shown.

[0100] As shown in Figure 6 , the calibration method of the embodiment includes the following contents:

[0101] In operation S610, in the calibration process, the target of the calibration target assembly 130 is arranged in the predetermined radiation area of the ultra-high dose rate radiation device 100;

[0102] In operation S620, the target portion is used as a reference to calibrate the intersection deviation of the plurality of radiation beams intersecting at the predetermined radiation region.

[0103] The calibration process disclosed herein, for example, starts from the installation of each beam module and ends when the intersection deviation meets the expected requirement. The expected requirement, for example, includes that the plurality of laser beams hit the sphere 131, and the radius of the sphere 131 is less than or equal to a certain error, such as 5 mm.

[0104] In some embodiments, the center of the target portion is located on the rotation axis of the rotating drum 120 during the calibration process.

[0105] In some embodiments, the plurality of laser assemblies are controlled to emit the plurality of laser beams to the target portion to simulate the intersection position of the plurality of radiation beams intersecting at the predetermined radiation region.

[0106] In some embodiments, the target portion includes the sphere 131, and the center of the sphere 131 is located on the rotation axis of the rotating drum 120 during the calibration process.

[0107] In some embodiments, the intersection deviation between any two of the plurality of laser beams is characterized by the meridians and the parallels on the sphere 131.

[0108] In some embodiments, the plurality of laser beams are guided to intersect at the surface of the sphere 131, including being guided to intersect at the same cross section of the center of the sphere 131.

[0109] In some embodiments, at least one dose detection module is used to detect a first actual dose of each radiation beam emitted by each beam module, and the intersection deviation is characterized by the difference between the first actual dose and a first theoretical dose of each radiation beam emitted by each beam module.

[0110] In some embodiments, the at least one dose detection module includes at least one dosimeter or at least one ionization chamber.

[0111] In some embodiments, the at least one dosimeter includes a plurality of dosimeters, and a plurality of radiation detection regions of the plurality of dosimeters are annularly distributed to correspond to a plurality of beam emission positions of the plurality of beam modules; the plurality of dosimeters are used to detect a first actual dose of each radiation beam of the plurality of radiation beams one by one.

[0112] In some embodiments, the at least one ionization chamber includes a plurality of ionization chambers, and a plurality of radiation incidence angles of the plurality of ionization chambers correspond to a plurality of beam emission positions of the plurality of beam modules to receive the plurality of radiation beams one by one; the plurality of ionization chambers are used to detect a second actual dose of each radiation beam of the plurality of radiation beams one by one.

[0113] For the part not mentioned in the calibration method part, it can be understood with reference to the above-mentioned various embodiments of the calibration device. That is, the calibration method part includes steps for controlling the respective structures of any one of the device embodiments described above to perform respectively. And the implementation, the technical problems solved, the functions realized, and the technical effects achieved of each step in the calibration method part embodiments are the same as or similar to the implementation, the technical problems solved, the functions realized, and the technical effects achieved of each corresponding structure in the calibration device part embodiments, which will not be described here.

[0114] It can be understood by those skilled in the art that the features described in various embodiments of the present disclosure can be combined and / or integrated in various combinations, even if such combinations or integrations are not explicitly described in the present disclosure. In particular, the features described in various embodiments of the present disclosure can be combined and / or integrated in various combinations without departing from the spirit and teachings of the present disclosure. All these combinations and / or integrations fall within the scope of the present disclosure. The embodiments of the present disclosure are described above. However, these embodiments are only for illustrative purposes, and are not intended to limit the scope of the present disclosure. Although each embodiment is described above separately, this does not mean that the measures in each embodiment cannot be used advantageously in combination. The scope of the present disclosure is defined by the appended claims and their equivalents. Without departing from the scope of the present disclosure, those skilled in the art can make various substitutions and modifications, which should all fall within the scope of the present disclosure.

Claims

1. A calibration device for an ultra-high dose rate radiation device, the ultra-high dose rate radiation device comprising multiple beam modules for emitting multiple radiation beams, the calibration device comprising: A calibration target assembly includes a target portion, wherein the target portion is located in a predetermined radiation region of the ultra-high dose rate radiation device during calibration; wherein the target portion is used as a reference to calibrate the convergence deviation of the multiple radiation beams converging in the predetermined radiation region; Multiple laser components are installed one-to-one at the beam emission positions of the multiple beam modules; wherein, the multiple laser components are used to emit multiple laser beams to the target to simulate the intersection position of the multiple radiation beams at the predetermined radiation region; The plurality of beam modules are mounted on the rotary drum of the ultra-high dose rate radiation device. The target is located in the predetermined radiation area of ​​the ultra-high dose rate radiation device during the calibration process, including: during the calibration process, the center of the target is located on the rotation axis of the rotary drum. The target portion includes: A sphere, wherein during calibration, the center of the sphere is located on the rotation axis of the rotating drum, and the sphere is marked with interwoven meridians and parallels, wherein the meridians and parallels are used to characterize the intersection deviation between any two laser beams in the multi-beam laser system.

2. The calibration device according to claim 1, characterized in that, The plurality of beam modules are arranged in a ring around the rotating drum. The sphere serves as a reference, guiding the multiple laser beams to converge on its surface.

3. The calibration device according to claim 2, characterized in that, The radius of the sphere is less than or equal to a predetermined threshold, and the center of the sphere coincides with the target point in the predetermined radiation region. The predetermined threshold is used to constrain the error between the hit position of any laser beam and the target radiotherapy position.

4. The calibration device according to claim 1, characterized in that, The calibration target assembly also includes a support frame, the support frame comprising: A base is installed on the inner wall of the rotary drum, and the curvature of the bottom surface of the base matches the curvature of the installation area on the inner wall of the rotary drum. The connector has a first end connected to the base and a second end connected to the sphere.

5. The calibration device according to claim 2, characterized in that, The beam emission positions of each of the multiple beam modules are equidistant from the target.

6. The calibration device according to claim 1, characterized in that, The target portion includes: At least one dose detection module is used to detect the first actual dose of the radiation beam emitted by each beam module; The difference between the first actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

7. The calibration device according to claim 6, characterized in that, The at least one dose detection module includes: At least one dosimeter is used to detect the first actual dose of the radiation beam emitted by each beam module.

8. The calibration device according to claim 7, characterized in that, The at least one dosimeter includes multiple dosimeters, and the multiple beam modules are arranged in a ring around the rotating drum of the ultra-high dose rate radiation device. The multiple radiation detection areas of the multiple dosimeters are arranged in a ring shape to correspond one-to-one with the multiple beam emission positions of the multiple beam modules; The plurality of dosimeters are used to detect the first actual dose of each of the plurality of radiation beams in a one-to-one correspondence.

9. The calibration device according to claim 6, characterized in that, The at least one dose detection module includes: At least one ionization chamber for detecting a second actual dose of the radiation beam emitted by each beam module; The difference between the second actual dose and the first theoretical dose of the radiation beam emitted by each beam module is used to characterize the intersection deviation.

10. The calibration device according to claim 9, characterized in that, The at least one ionization chamber comprises multiple ionization chambers, and the multiple beam modules are arranged in a ring around the rotating drum of the ultra-high dose rate radiation device. The multiple incident angles of the multiple ionization chambers correspond one-to-one with the multiple beam emission positions of the multiple beam modules, so as to receive the multiple radiation beams one-to-one. The plurality of ionization chambers are used to detect the second actual dose of each of the plurality of radiation beams in a one-to-one correspondence.

11. A calibration method for an ultra-high dose rate radiation device, used in the calibration equipment according to any one of claims 1 to 10, wherein the ultra-high dose rate radiation device comprises a plurality of beam modules for emitting multiple radiation beams, and the calibration method comprises: During the calibration process, the target of the calibration target assembly is placed in the predetermined radiation area of ​​the ultra-high dose rate radiation device; The target is used as a reference to calibrate the convergence deviation of the multiple radiation beams converging in the predetermined radiation region.

12. An ultra-high dose rate radiation device, comprising: Rotary drum; Multiple beam modules for emitting multiple radiation beams, wherein the multiple beam modules are distributed in a ring around the rotating drum; The plurality of beam modules are configured to be calibrated by the calibration device according to any one of claims 1 to 10, so as to converge the plurality of radiation beams into a predetermined radiation region.

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