Fluorescent probe with dual response to ferrous ions and viscosity in Parkinson's disease model as well as preparation method and application of fluorescent probe

By developing a fluorescent probe with strong specificity and high sensitivity that responds to ferrous ions and viscosity in Parkinson's disease model, the problem of poor specificity and high background interference in the prior art was solved, and efficient monitoring of ferrous ions and viscosity in Parkinson's disease was achieved, with good biocompatibility and detection effect.

CN119638641AActive Publication Date: 2025-03-18SHANXI MEDICAL UNIV
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Patent Information

Application Number
CN202411890487.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-20
Publication Date
2025-03-18
Estimated Expiration
2044-12-20

AI Technical Summary

Technical Problem

The existing Fe2+ fluorescent probes are not specific, have low sensitivity, and have large background interference, making it difficult to effectively monitor the dynamic changes in ferrous ions and viscosity in Parkinson's disease.

Method used

A fluorescent probe that responds to ferrous ions and viscosity in Parkinson's disease model was developed. It has the characteristics of strong specificity, low background interference and high detection sensitivity. Through specific chemical structures and preparation methods, efficient detection of Fe2+ and viscosity is achieved.

Benefits of technology

This fluorescent probe successfully fluorescence imaging in living cells, nematodes and fruit fly brain tissues, can monitor changes in ferrous ions and viscosity with high sensitivity, has good biocompatibility and low background fluorescence, and is suitable for early diagnosis and research of Parkinson's disease.

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Abstract

The invention discloses a dual-response fluorescent probe for ferrous ions and viscosity in a Parkinson's disease model, which is an off-on type fluorescent probe, can well realize dual response to ferrous ions and viscosity, and has the advantages of strong specificity, low background interference, high detection sensitivity, emission wavelength, better biocompatibility, low biological background fluorescence and the like. The fluorescent probe is successfully applied to fluorescence imaging in living cells and brain tissues of nematodes and drosophila melanogaster. The invention further discloses a preparation method and application. The preparation method is easy to operate and mild in condition. The fluorescent probe is successfully applied to biological systems including living cells, caenorhabditis elegans and drosophila melanogaster, and ferrous ion and viscosity level detection is successfully carried out by using a confocal microscope.
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