Wearable electrocardiogram monitoring system based on clothes type thermoelectric generator

Abstract

The invention belongs to the technical field of wearable intelligent health monitoring, and particularly discloses a wearable electrocardiogram monitoring system based on a clothes type thermoelectric generator. The wearable electrocardiogram monitoring system comprises a clothes type thermoelectric power generation unit, a heartbeat monitoring unit and an upper computer, the heartbeat monitoring unit comprises a voltage transformation circuit and an electrocardio data acquisition module, and the upper computer comprises an analysis unit and a display; the clothes type thermoelectric power generation unit is used for supplying power to the heartbeat monitoring unit, the electrocardio data acquisition module is used for acquiring and wirelessly transmitting electrocardio data and heart rate data, and the analysis unit is used for analyzing the heart rate data stored by the upper computer and judging the risk of pulmonary arterial hypertension according to resting heart rate data, maximum heart rate data and time-varying heart rate data. The clothes type thermoelectric power generation unit and the heartbeat monitoring unit are both worn on the arms of the human body, and the clothes type thermoelectric power generation device has the advantages of being portable, light and the like, can be used as auxiliary diagnosis equipment for judging pulmonary arterial hypertension and has huge potential in medicine.

Description

Technical Field

[0001] The present invention relates to the field of wearable intelligent health monitoring technology, and in particular to a wearable electrocardiogram monitoring system based on a clothing-type thermoelectric generator. Background Art

[0002] Pulmonary hypertension is a serious disease characterized by increased pulmonary artery pressure, which often causes abnormal changes in the patient's heart rate. Therefore, heart rate monitoring is of great significance for patients with pulmonary hypertension. Traditional heart rate monitoring relies on equipment such as electrocardiograms, which are large and bulky, not easy to carry and require external power supply. This will undoubtedly increase the burden on patients with pulmonary hypertension during the monitoring process and easily cause inaccurate monitoring data.

[0003] Currently, the gold standard for diagnosing pulmonary hypertension is right cardiac catheterization, which is an invasive examination method. This method can clearly diagnose pulmonary hypertension, but invasive examinations are prone to infection at the wound site, which is not very comfortable for patients and requires high technical skills from doctors. Therefore, researchers are committed to developing a non-invasive method for early identification of pulmonary hypertension.

[0004] The 6-minute walk test is a simple, economical and safe method for evaluating a patient's exercise tolerance and cardiopulmonary function. Exploring changes in heart rate during the 6-minute walk test is of great significance for the analysis of pulmonary hypertension. At present, the 6-minute walk test device is large and bulky. Weight-bearing exercise is undoubtedly worse for patients with pulmonary hypertension who already have abnormal heart rates, leading to more serious comfort problems and easily affecting the test results. Moreover, the current 6-minute walk test device cannot test heart rate changes in real time, and dynamic physiological data has limitations for medical analysis. Therefore, there is a need for a portable, wearable real-time heart rate monitoring device for heart rate monitoring in daily life or in medical fields such as patients with pulmonary hypertension. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides a wearable electrocardiogram monitoring system based on a clothing-type thermoelectric power generation device. The wearable electrocardiogram monitoring system includes a clothing-type thermoelectric power generation unit and a heartbeat monitoring unit, both of which are worn on the human arm. It has the advantages of being portable and lightweight, and can be used as an auxiliary diagnostic device for the diagnosis of pulmonary hypertension, and has great potential in medicine.

[0006] A wearable electrocardiogram monitoring system based on a clothing-type thermoelectric power generation device, the wearable electrocardiogram monitoring system includes a clothing-type thermoelectric power generation unit, a heartbeat monitoring unit and a host computer. The clothing-type thermoelectric power generation unit includes a thermoelectric power generation unit and an elastic cloth, the heartbeat monitoring unit includes a transformer circuit and an electrocardiogram data acquisition module, and the host computer includes an analysis unit and a display. The clothing-type thermoelectric power generation unit is used to supply power to the heartbeat monitoring unit, the electrocardiogram data acquisition module collects and wirelessly transmits electrocardiogram data and heart rate data, the host computer is used to store electrocardiogram data and heart rate data, the analysis unit is used to analyze the heart rate data stored in the host computer, and is used to judge the risk of pulmonary hypertension based on resting heart rate data, maximum heart rate data, and time-varying heart rate data, and the display displays various data, graphs and / or analysis results, and the judgment results of the risk of pulmonary hypertension. After the clothing-type thermoelectric power generation unit is worn on the human forearm, the bottom surface of the thermoelectric power generation unit is in close contact with the human skin, and electricity is generated based on the temperature difference between the human skin and the air. After being boosted by the transformer circuit included in the heartbeat monitoring unit, power is supplied to the electrocardiogram data acquisition module included in the heartbeat monitoring unit worn on the back arm of the human body.

[0007] Furthermore, the thermoelectric power generation unit is embedded in the elastic cloth to form a clothing-type thermoelectric power generation unit, which is composed of P-type and N-type semiconductor thermoelectric particles and Kirigami structure flexible printed circuit board (FPCB) electrodes. The external positive and negative wires of the clothing-type thermoelectric power generation unit are respectively connected to the input end of the voltage transformer circuit of the heartbeat monitoring unit. The voltage transformer circuit stores the electricity in the capacitor, and boosts the voltage to 3V through the voltage transformer chip (LTC3108) to input to the ECG data acquisition module for power supply; the three electrodes of the ECG data acquisition module are respectively attached to the first intercostal space of the left clavicle midline, the first intercostal space of the right clavicle midline, and the sixth intercostal space of the left clavicle midline to collect ECG data, and the collected ECG data is transmitted to the host computer infinitely.

[0008] Furthermore, the voltage conversion circuit utilizes the LTC3108 chip, which is connected to a small step-up transformer. The positive and negative electrodes of the thermoelectric power generation unit are connected to the input terminals of the transformer respectively. The electric energy increases the input voltage through the transformer and the coupling capacitor, and the increased voltage is output to the ECG data acquisition module through the VOUT pin. A storage capacitor is designed in the voltage conversion circuit and connected to the VOUT pin of the LTC3108. When there is no load, the thermoelectric power generation unit charges the storage capacitor to provide power when there is no power supply.

[0009] Furthermore, the ECG data acquisition module is based on a commercial AD8232 module, which includes three electrodes. The single-lead ECG mode is adopted, and the three electrodes are respectively attached to the first intercostal space of the left clavicle midline, the first intercostal space of the right clavicle midline, and the sixth intercostal space of the left clavicle midline. The collected ECG data and heart rate data are filtered and amplified and output to the data serial port, so as to be infinitely transmitted to the host computer.

[0010] Furthermore, the host computer is used to store ECG data and heart rate data, and the display shows the ECG, real-time heart rate and analysis results. The wearable ECG monitoring system includes a clothing-type thermoelectric power generation unit and a heartbeat monitoring unit, which are worn on the forearm and hind arm of the human body in sequence; after wearing, the resting heart rate is first tested, and then a 6-minute walking test is performed to obtain the maximum heart rate, and the time-varying heart rate is obtained based on the obtained resting heart rate and maximum heart rate; the analysis unit makes the following judgments on the resting heart rate, maximum heart rate and time-varying heart rate, and the display shows the real-time ECG, real-time heart rate, resting heart rate, maximum heart rate and judgment results:

[0011] (1) Whether the resting heart rate is between 60 and 100 beats per minute;

[0012] (2) the time when the maximum heart rate occurred during the 6-minute walk test;

[0013] (3) whether the time-varying heart rate is ≥40 beats / min;

[0014] (4) If the resting heart rate is less than 60 beats / minute, the display shows "bradycardia"; if the resting heart rate is greater than 100 beats / minute, the display shows "tachycardia"; if the time-varying heart rate reaches 40 beats / minute, the display shows "risk of pulmonary hypertension"; in all other cases, the display shows "low risk of pulmonary hypertension".

[0015] Compared with the prior art, the advantages and beneficial effects of the present invention are as follows:

[0016] 1. The wearable electrocardiogram monitoring system based on clothing-type thermoelectric power generation devices of the present invention, the clothing-type thermoelectric power generation unit and the heartbeat monitoring unit are both worn on the human arm, which has the advantages of portability and lightness, and has great potential in medicine; wherein, the working principle of the thermoelectric power generation unit is: according to the Seebeck principle, based on the temperature difference between the inner and outer surfaces of the respiratory monitoring unit of the thermoelectric device, a temperature difference is formed at both ends of the semiconductor thermoelectric particles that are thermally parallel and electrically series connected, and the thermoelectric device outputs a voltage. The heat generated by the human body contacts the thermoelectric power generation device, causing a temperature difference at both ends of the thermoelectric power generation device, thereby generating electricity. The present invention adopts the method of directly contacting the thermoelectric legs with the human skin, and utilizes the Kirigami structure FPCB electrode to enhance the tensile performance so as to better fit the complex surface of the human skin. The thermoelectric power generation device has excellent output performance. When the temperature difference is 30K, the maximum open circuit voltage is 940mV and the maximum output power is 23.8mW.

[0017] 2. The present invention conducted a 6-minute walking test on 40 groups of volunteers with pulmonary hypertension and cardiopulmonary health, monitored heart rate changes in real time throughout the whole process, and conducted statistical analysis on their resting heart rate and maximum heart rate during the 6-minute walk. A T test was performed on the difference between the maximum heart rate during the 6-minute walk and the resting heart rate, proving that this indicator has significant statistical differences for patients with pulmonary hypertension and volunteers with cardiopulmonary health. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 is a physical diagram of a wearable electrocardiogram monitoring system of the present invention;

[0019] Figure 2 It is the output voltage and power diagram of the thermoelectric power generation unit; the test process is: first place the clothing-type thermoelectric power generation unit on the heating table, insert thermocouples into the upper and lower surfaces of the clothing-type thermoelectric power generation unit; then place a water-cooled radiator on the upper surface of the clothing-type thermoelectric power generation unit and the corresponding thermocouple; then, connect the positive and negative poles of the clothing-type thermoelectric power generation unit to the adjustable rheostat box, and use a multimeter to test the current and voltage of the clothing-type thermoelectric power generation unit respectively; then, turn on the heating table to heat, so that the temperature difference between the upper and lower surfaces of the clothing-type thermoelectric power generation unit reaches 10℃, 20℃ and 30℃, and record the output voltage and current of the clothing-type thermoelectric power generation unit; finally, draw the output voltage and power diagram based on the obtained data;

[0020] Figure 3 It is an electrocardiogram while sitting upright; the test process is as follows: the volunteer wears the clothing-type thermoelectric power generation unit (forearm) and the heartbeat monitoring unit (back arm) of the present invention as required, and the clothing-type thermoelectric power generation unit supplies power to the heartbeat monitoring unit; then, the three electrodes included in the heartbeat monitoring unit are attached to the volunteer as required by the test; the volunteer sits quietly for ten minutes in the sitting state and then the test is carried out; the upper computer displays the heart rate and electrocardiogram in real time;

[0021] Figure 4 This is the resting heart rate distribution diagram of volunteers;

[0022] Figure 5 It is the maximum heart rate distribution diagram obtained by volunteers during the 6-minute walking test;

[0023] Figure 6 It is a statistical analysis chart of the time-varying heart rate obtained by volunteers during a 6-minute walking test;

[0024] Figure 7 The ROC curves and cut-off values ​​of time-varying heart rate of 40 groups of patients with pulmonary hypertension and volunteers with healthy heart and lungs are shown;

[0025] Figure 8 is a real-life picture of a volunteer wearing the wearable electrocardiogram monitoring system of the present invention performing a 6-minute walking test;

[0026] Fig. 9 The figure is a graph showing changes in heart rate over time during a 6-minute walking test of a volunteer wearing the wearable electrocardiogram monitoring system of the present invention. DETAILED DESCRIPTION

[0027] The present invention is further described below in conjunction with the accompanying drawings and embodiments. The present invention is not limited by the following embodiments, and the specific implementation method can be determined based on the technical solution of the present invention and actual conditions.

[0028] like Figure 1 A wearable electrocardiogram monitoring system based on a clothing-type thermoelectric power generation device, the system includes a clothing-type thermoelectric power generation unit, a heartbeat monitoring unit and a host computer. The clothing-type thermoelectric power generation unit includes a thermoelectric power generation unit and an elastic cloth, the heartbeat monitoring unit includes a transformer circuit, an electrocardiogram data acquisition module, and the host computer includes an analysis unit and a display. The clothing-type thermoelectric power generation unit is used to power the heartbeat monitoring unit, the electrocardiogram data acquisition module is used to collect and wirelessly transmit electrocardiogram data and heart rate data, the host computer is used to store electrocardiogram data and heart rate data, and display an electrocardiogram, and the analysis unit is used to analyze the data stored in the host computer. After the clothing-type thermoelectric power generation unit is worn on the forearm of the human body, the bottom surface of the thermoelectric power generation unit is in close contact with the human skin, and based on the temperature difference between the human skin and the air, electricity is generated, and after being boosted by the transformer circuit included in the heartbeat monitoring unit, power is supplied to the electrocardiogram data acquisition module included in the heartbeat monitoring unit worn on the back arm of the human body.

[0029] The thermoelectric power generation unit is embedded in the elastic cloth to form a clothing-type thermoelectric power generation unit, which is composed of P-type and N-type semiconductor thermoelectric particles and Kirigami structure flexible printed circuit board (FPCB) electrodes. The external positive and negative wires of the clothing-type thermoelectric power generation unit are respectively connected to the input end of the voltage transformer circuit of the heartbeat monitoring unit. The voltage transformer circuit stores the electricity in the capacitor, and boosts the voltage to 3V through the voltage transformer chip (LTC3108) to input to the ECG data acquisition module for power supply; the three electrodes of the ECG data acquisition module are respectively attached to the first intercostal space of the left clavicle midline, the first intercostal space of the right clavicle midline, and the sixth intercostal space of the left clavicle midline to collect ECG data, and the collected ECG data is transmitted to the host computer infinitely.

[0030] The manufacturing process of the Kirigami structure flexible printed circuit board electrode in this embodiment is the same as the manufacturing method described in the "Specific Implementation Method" in the specification of the invention patent application CN116761491A. The manufacturing process of the thermoelectric power generation unit is as follows:

[0031] (1) Processing of elastic fabric: Commercial elastic fabric was selected as the flexible substrate, and a hole array through which the thermoelectric particles passed was prepared on the elastic fabric by laser cutting. The hole array had a length of 1.4 mm, a width of 1.4 mm, and a hole spacing of 2 mm.

[0032] (2) Preparation of P-type and N-type semiconductor thermoelectric particles: Sb2Te3 is used as the raw material of P-type semiconductor thermoelectric particles, and Bi2Te3 is used as the raw material of N-type semiconductor thermoelectric particles. Both P-type and N-type semiconductor thermoelectric particles are formed into blocks with a size of 1.4×1.4×2.5 mm. The spacing between the thermoelectric particles matches the spacing between the holes in the hole array on the elastic cloth, both of which are 2 mm.

[0033] (3) Preparation of Kirigami structure flexible printed circuit board electrodes: According to the preparation method described in the "Specific Implementation Method" in the specification of the invention patent application CN116761491A, Kirigami structure flexible printed circuit board electrodes as upper and lower electrodes are processed, and the upper electrode is adapted to the lower electrode; the flexible printed circuit board electrodes are based on a polyimide film, and the required electrodes are prepared on the polyimide film, and the electrodes are prepared by laser cutting as shown in FIG. Figure 1 The Kirigami structure shown, wherein each flexible PCB board of the Kirigami structure includes 10×8 geometric units, and the spacing between adjacent geometric units is 5 mm;

[0034] (4) placing the Kirigami structure flexible printed circuit board electrode as the lower electrode prepared in step (3) on a heating plate, coating a layer of tin paste on the metal electrode surface of the flexible printed circuit board electrode, and then alternately placing P-type and N-type semiconductor thermoelectric particles on the tin paste coated on the surface of the corresponding electrode, with the spacing between each thermoelectric particle being 2 mm; after placement, pressing a glass plate on it to prevent the P-type and N-type semiconductor thermoelectric particles from moving during heating; heating the heating plate to 150° C., and after welding is completed, naturally cooling to room temperature and then removing the glass plate;

[0035] (5) After completing step (4), the elastic cloth of step (1) is covered on the surface of the P-type and N-type semiconductor thermoelectric particles, and the elastic cloth is pressed downward to allow the P-type and N-type semiconductor thermoelectric particles to pass through the hole array; then, a layer of tin paste is coated on the top of the P-type and N-type semiconductor thermoelectric particles, and then the Kirigami structure flexible printed circuit board electrode as the upper electrode is placed on the P-type and N-type semiconductor thermoelectric particles with the tin paste coated on the top, and the geometric units in the Kirigami structure flexible printed circuit board electrode as the upper and lower electrodes correspond to each other up and down, so that the P-type and N-type semiconductor thermoelectric particles in each geometric unit form an electrically series and thermally parallel structure; then, the geometric units are connected by wires, so that the whole forms an electrically series and thermally parallel structure; finally, the heating temperature of the heating plate is adjusted to 150° C., and the welding is completed at a heating temperature of 150° C.

[0036] The voltage conversion circuit uses the LTC3108 chip, which is connected to a small step-up transformer. The positive and negative poles of the thermoelectric power generation unit are connected to the input of the transformer respectively. The electric energy increases the input voltage through the transformer and the coupling capacitor, and the increased voltage is output to the ECG data acquisition module through the VOUT pin. A storage capacitor is designed in the voltage conversion circuit and connected to the VOUT pin of the LTC3108. When there is no load, the thermoelectric power generation unit charges the storage capacitor to provide power when there is no power supply.

[0037] The ECG data acquisition module is based on the commercial AD8232 module, which contains 3 electrodes. The single-lead ECG mode is adopted, and the 3 electrodes are respectively attached to the first intercostal space of the left clavicle midline, the first intercostal space of the right clavicle midline, and the sixth intercostal space of the left clavicle midline. The collected ECG data and heart rate data are filtered and amplified and output to the serial port, and then wirelessly transmitted to the host computer.

[0038] The host computer is used to store ECG data and heart rate data, and display ECG, real-time heart rate and analysis results.

[0039] The wearable ECG monitoring system was used to perform a 6-minute walk test on 40 groups of patients with pulmonary hypertension and volunteers with healthy heart and lungs. Figure 8 ), real-time recording of the maximum heart rate during the test and the resting heart rate before the test. The analysis unit included in the host computer performs statistical analysis (T test) on the collected heart rate data. The statistical analysis results show that for patients with pulmonary hypertension and volunteers with healthy heart and lungs, the difference between the maximum heart rate and the resting heart rate in the 6-minute walking test has a significant statistical difference.

[0040] 6-minute walk test

[0041] 1. Environmental conditions: A 30-meter test corridor provided by the hospital with suitable temperature, quietness and good air circulation, with markings every 3 meters and cone signs at the turning points.

[0042] 2. Test preparation: 40 groups of volunteers were selected, each group of volunteers consisted of one pulmonary hypertension patient (PH) and one cardiopulmonary healthy volunteer (Control): In each group, the cardiopulmonary healthy volunteers matched the pulmonary hypertension patients in terms of gender, age and body mass index. Before the test, the 40 groups of volunteers wore the above-mentioned wearable ECG monitoring system according to the test requirements, and changed into test clothes and shoes to ensure comfortable wearing; the pulmonary hypertension patients in each group continued to use their usual conventional treatment drugs as usual, and there was no recent adjustment of treatment drugs.

[0043] 3. Resting heart rate test: 40 groups of volunteers rested for 10 minutes at the starting point of the 6-minute walk test without strenuous activity within 3 hours after a meal to test their resting heart rate; the ECG data acquisition module collected ECG data and heart rate data and transmitted them wirelessly to the host computer.

[0044] 4. Maximum heart rate test: After the resting heart rate test, 40 groups of volunteers walked back and forth along the corridor as fast as possible within 6 minutes ("as fast as possible" means the maximum speed within the tolerance range of the volunteers according to the requirements of the 6-minute walking test), and did not hesitate or stop when turning; the ECG data acquisition module collected ECG data and heart rate data, and transmitted them wirelessly to the host computer.

[0045] 5. The host computer stores the ECG data and heart rate data, and displays the ECG and real-time heart rate on the display screen.

[0046] 6. Statistical analysis of the analysis unit of the host computer: Analyze the heart rate data collected by the ECG data acquisition module and transmitted to the host computer, including analysis of resting heart rate data, analysis of maximum heart rate data, and analysis of time-varying heart rate (maximum heart rate - resting heart rate = time-varying heart rate) data, as follows:

[0047] (6.1) The resting heart rate data of 40 groups of volunteers were divided into two groups: one group was the resting heart rate data of patients with pulmonary hypertension (PH), and the other group was the resting heart rate data of volunteers with healthy heart and lungs (Control). Then, the data of the two groups were statistically analyzed respectively, and the obtained statistical distribution histogram was as follows: Figure 4 , calculate its normal distribution parameters, and compare the difference in confidence intervals between the two: the 95% confidence interval of the resting heart rate of volunteers with cardiopulmonary health is 61-108 beats / min, while the 95% confidence interval of the resting heart rate of patients with pulmonary hypertension is 53-103 beats / min;

[0048] (6.2) The maximum heart rate data obtained by the 6-minute walking test of 40 groups of volunteers were divided into two groups: one group was the maximum heart rate data of patients with pulmonary hypertension, and the other group was the maximum heart rate data of volunteers with healthy heart and lungs. Then, the data of the two groups were statistically analyzed respectively, and the obtained statistical distribution histogram was as follows: Figure 5 , calculate its normal distribution parameters, and compare the difference in confidence intervals between the two: the 95% confidence interval of the maximum heart rate of volunteers with healthy heart and lungs is in the range of 82-150 beats / min, while the 95% confidence interval of the maximum heart rate of patients with pulmonary hypertension is in the range of 87-167 beats / min; the maximum heart rate of volunteers with pulmonary hypertension is higher than that of volunteers with healthy heart and lungs;

[0049] (6.3) The time-varying heart rate data obtained from the test of 40 groups of volunteers were divided into two groups: one group was the time-varying heart rate data of patients with pulmonary hypertension, and the other group was the time-varying heart rate data of volunteers with healthy heart and lungs. Then, the data of the two groups were statistically analyzed and made into box plots as shown below. Figure 6 As shown, by comparing the medians and quartiles of the two, P<0.001 was obtained through T test, indicating that there was a significant statistical difference in this index between the pulmonary hypertension patient group and the cardiopulmonary healthy volunteer group;

[0050] (6.4) Receiver operating characteristic curve (ROC curve) processing was performed on the time-varying heart rate data of 40 groups of 80 volunteers ( Figure 7 ), the cut-off value is 40bpm, the sensitivity is 65%, and the specificity is 87.5%. After calculation, in the 40 groups of time-varying heart rate data of 80 volunteers, if the time-varying heart rate reaches 40bpm, the accuracy rate of judging the volunteer as a patient with pulmonary hypertension is 75%.

[0051] like Fig. 9 The display shows the time when the maximum heart rate occurs. The maximum heart rate of the PH group occurs at the 5th minute, while the maximum heart rate of the Control group occurs at the end of the 6th minute. On the one hand, the maximum heart rate of the PH group does not appear at the end of 6 minutes, which shows that the wearable electrocardiogram monitoring system of the present invention can perform stable real-time monitoring. On the other hand, it shows that the maximum heart rate of patients with pulmonary hypertension does not necessarily appear at the end of 6 minutes like the maximum heart rate of people with healthy heart and lungs.

[0052] The wearable electrocardiogram monitoring system of the present invention can dynamically monitor the heart rate fluctuation of the tester in a better manner.

[0053] Thus, a person uses the wearable electrocardiogram monitoring system of the present invention, and wears the clothing-type thermoelectric power generation unit and the heartbeat monitoring unit on the forearm and the back arm in sequence; after wearing, the resting heart rate is first tested, and then a 6-minute walking test is performed to obtain the maximum heart rate, and the time-varying heart rate is obtained based on the obtained resting heart rate and maximum heart rate; the analysis unit makes the following judgments on the resting heart rate, maximum heart rate, and time-varying heart rate, and the display shows the real-time electrocardiogram, real-time heart rate, resting heart rate, maximum heart rate, and judgment results:

[0054] (1) Whether the resting heart rate is between 60 and 100 beats per minute;

[0055] (2) the time when the maximum heart rate occurred during the 6-minute walk test;

[0056] (3) whether the time-varying heart rate is ≥40 beats / min;

[0057] (4) If the resting heart rate is less than 60 beats / min, the display shows "bradycardia"; if the resting heart rate is greater than 100 beats / min, the display shows "tachycardia"; if the time-varying heart rate is ≥40 beats / min, the display shows "risk of pulmonary hypertension"; in all other cases, the display shows "low risk of pulmonary hypertension".

[0058] Based on the above statistical analysis, the wearable electrocardiogram monitoring system of the present invention realizes the collection of electrocardiogram data and heart rate data, is comfortable to wear, easy to use, has good real-time performance, a wide range of application scenarios, and has a good monitoring effect. When a user wears the wearable electrocardiogram monitoring system of the present invention, by obtaining the resting heart rate, maximum heart rate, and time-varying heart rate, it can be determined whether the user suffers from pulmonary hypertension. Therefore, the wearable electrocardiogram monitoring system of the present invention can be used as an auxiliary diagnostic device for the determination of pulmonary hypertension.

[0059] The above are only preferred embodiments of the present invention. It should be pointed out that a person skilled in the art can make several modifications and improvements without departing from the inventive concept of the present invention, and these all fall within the protection scope of the present invention.

Claims

1. A wearable electrocardiogram monitoring system based on a clothing-type thermoelectric power generation device, the wearable electrocardiogram monitoring system comprising a clothing-type thermoelectric power generation unit, a heartbeat monitoring unit and a host computer; the clothing-type thermoelectric power generation unit comprises a thermoelectric power generation unit and an elastic cloth, the heartbeat monitoring unit comprises a transformer circuit and an electrocardiogram data acquisition module, and the host computer comprises an analysis unit and a display; the clothing-type thermoelectric power generation unit is used to supply power to the heartbeat monitoring unit, the electrocardiogram data acquisition module acquires and wirelessly transmits electrocardiogram data and heart rate data, the host computer is used to store and display electrocardiogram data and heart rate data, the analysis unit is used to analyze the heart rate data stored in the host computer, and to judge the risk of pulmonary hypertension according to the resting heart rate data, the maximum heart rate data, and the time-varying heart rate data, and the display displays various data, graphs and / or analysis results, and the judgment results of the risk of pulmonary hypertension; After the clothing-type thermoelectric power generation unit is worn on the front arm of the human body, the bottom surface of the thermoelectric power generation unit is in close contact with the human skin, and based on the temperature difference between the human skin and the air, the electrocardiogram data acquisition module included in the heartbeat monitoring unit worn on the back arm of the human body is supplied with power after the voltage is stepped up by the voltage conversion circuit included in the heartbeat monitoring unit; The wearable electrocardiogram monitoring system includes a clothing-type thermoelectric power generation unit and a heartbeat monitoring unit, which are sequentially worn on the forearm and the back arm of a human body; after wearing, the resting heart rate is first tested and then a 6-minute walking test is performed to obtain the maximum heart rate, and the time-varying heart rate is obtained based on the obtained resting heart rate and maximum heart rate; The analysis unit makes the following judgments on the resting heart rate, maximum heart rate, and time-varying heart rate, and the display shows the real-time electrocardiogram, real-time heart rate, resting heart rate, maximum heart rate, and judgment results: (1) Is the resting heart rate between 60 and 100 beats per minute? (2) The time when the maximum heart rate occurs during the 6-minute walk test; (3) Whether the time-varying heart rate is ≥40 beats / min; (4) If the resting heart rate is less than 60 beats / min, the display shows "bradycardia"; if the resting heart rate is greater than 100 beats / min, the display shows "tachycardia"; if the time-varying heart rate reaches 40 beats / min, the display shows "risk of pulmonary hypertension"; in all other cases, the display shows "low risk of pulmonary hypertension".

2. The wearable electrocardiogram monitoring system according to claim 1, characterized in that: The thermoelectric power generation unit is embedded in the elastic cloth to form a clothing-type thermoelectric power generation unit, which is composed of P-type and N-type semiconductor thermoelectric particles and Kirigami structure flexible printed circuit board electrodes; the external positive and negative wires of the clothing-type thermoelectric power generation unit are respectively connected to the input end of the voltage conversion circuit of the heartbeat monitoring unit; the voltage conversion circuit stores the electricity in the capacitor, and boosts the voltage to 3V through the voltage conversion chip LTC3108 to input to the electrocardiogram data acquisition module for power supply; The three electrodes of the ECG data acquisition module are respectively attached to the first intercostal space of the left clavicle midline, the first intercostal space of the right clavicle midline and the sixth intercostal space of the left clavicle midline to collect ECG data, and the collected ECG data are transmitted to the host computer indefinitely.

3. The wearable electrocardiogram monitoring system according to claim 1, characterized in that: The voltage conversion circuit utilizes the LTC3108 chip, which is connected to a small step-up transformer. The positive and negative poles of the thermoelectric power generation unit are respectively connected to the input ends of the transformer. The electric energy increases the input voltage through the transformer and the coupling capacitor, and the increased voltage is output to the ECG data acquisition module through the VOUT pin. A storage capacitor is designed in the voltage conversion circuit and connected to the VOUT pin of the LTC3108. When there is no load, the thermoelectric power generation unit charges the storage capacitor to provide power when there is no power supply.

4. The wearable electrocardiogram monitoring system according to claim 2, characterized in that: The ECG data acquisition module is based on the commercial AD8232 module, which contains three electrodes. It adopts the single-lead ECG mode and attaches the three electrodes to the first intercostal space of the left midclavicular line, the first intercostal space of the right midclavicular line, and the sixth intercostal space of the left midclavicular line respectively. The collected ECG data and heart rate data are filtered and amplified, and then transmitted to the host computer via wireless.

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