V-v interval optimization method, device and equipment of crt and storage medium

Abstract

A V-V interval optimization method, device and equipment of CRT and storage medium, the method comprises: obtaining the electrocardiogram data of the target;According to the electrocardiogram data, the total QRS time of the target, the first time difference value of the QRS wave starting point to the V2, V5 lead of the chest and the first time difference value of the QRS wave starting point to the aVL limb lead are obtained;According to the first ratio of the first time difference value and the total QRS time, and the second ratio of the second time difference value and the total QRS time, whether the target heart needs to be optimized is judged;If it needs to be optimized, the V-V interval of CRT is optimized in the direction of reducing the first ratio and the second ratio.Finally, the V-V parameter of CRT can be optimized through the conventional twelve-lead electrocardiogram, and the value of electrocardiogram examination and the efficiency of CRT optimization are improved.

Description

Technical Field

[0001] This application relates to the field of cardiac resynchronization therapy technology, specifically to a method, apparatus, device, and storage medium for optimizing the VV interval of a CRT. Background Technology

[0002] In recent years, the incidence of heart failure (HF) has been increasing year by year, and its five-year survival rate is lower than that of malignant tumors, making it a major threat to human health. 1. In heart failure, the heart enlarges, especially the left ventricle, which is significantly dilated. This structural abnormality leads to abnormal changes in the heart's electrical and mechanical activity. 70% of heart failure patients have complete left bundle branch block (LBBB). In this case, under supraventricular rhythm, after the interventricular septum is activated, the activation of the left ventricular lateral wall is significantly delayed, causing asynchronous ventricular contraction, reduced cardiac ejection fraction, and a series of clinical symptoms of heart failure. In addition to traditional drug treatment, cardiac resynchronization therapy (CRT) has become a routine treatment for heart failure, especially for patients with heart failure accompanied by left bundle branch block. 2-3

[0003] After cardiac resuscitation (CRT) implantation, optimizing the pacemaker parameters is crucial for its therapeutic effectiveness. CRT parameter optimization primarily refers to optimizing the atrioventricular interval and its left and right ventricular intervals (VV intervals), especially the latter, which plays a decisive role in the therapeutic effect of CRT. VV interval optimization methods include: 1. echocardiography, 2. QRS complex width, 3. cardiac catheterization, and 4. intracardiac electrocardiography. These methods guide CRT parameter adjustments to achieve optimal ventricular synchronization and cardiac ejection. Cardiac catheterization and intracardiac electrocardiography require hospitalization and are invasive procedures, therefore they are not routinely used.

[0004] Currently, echocardiography-guided parameter optimization is widely used; however, its clinical application is limited due to its time-consuming nature, high cost, and poor patient compliance. Measuring the QRS width in a standard electrocardiogram (ECG) to guide CRT parameter optimization, with the VV interval at the narrowest QRS complex as the optimal treatment parameter, is relatively simple, quick, and inexpensive compared to echocardiography. However, because the QRS width is influenced by multiple factors, it cannot accurately reflect the synchronization of left and right ventricular contractions and myocardial contraction within the left ventricle, thus its specificity is not high. Therefore, finding a time-efficient, easy-to-operate, inexpensive, and highly specific method to optimize CRT patients' treatment parameters is particularly necessary. Summary of the Invention

[0005] This application provides a method, apparatus, device, and storage medium for optimizing the VV interval of a CRT, which can solve the technical problems existing in the prior art.

[0006] In a first aspect, embodiments of this application provide a method for optimizing the VV interval of a CRT, employing the following technical solution:

[0007] A method for optimizing the VV interval of the CRT, the method comprising:

[0008] Obtain the target's electrocardiogram data;

[0009] Based on the electrocardiogram data, the total QRS duration of the target, the first time difference from the QRS wave initiation to the in-situ tortuosity in the precordial leads V2 and V5, and the second time difference from the QRS wave initiation to the in-situ tortuosity in the limb lead aVL are obtained.

[0010] Based on the first ratio of the first time difference to the total QRS time, and the second ratio of the second time difference to the total QRS time, it is determined whether the contraction synchronicity of the target heart needs to be optimized.

[0011] If optimization is needed, optimize the VV interval of CRT by reducing the first ratio and the second ratio.

[0012] In conjunction with the first aspect, in one implementation, determining whether the contractile synchronicity of the target heart needs optimization based on a first ratio of the first time difference to the total QRS time and a second ratio of the second time difference to the total QRS time includes the following steps:

[0013] Determine whether the first ratio is greater than the first threshold, and whether the second ratio is greater than the second threshold;

[0014] If the first ratio is greater than the first threshold or the second ratio is greater than the second threshold, then the contraction synchronicity of the target heart needs to be optimized; otherwise, no optimization is needed.

[0015] In conjunction with the first aspect, in one implementation, optimizing the VV interval of the CRT in the direction of reducing the first ratio and the second ratio includes the following steps:

[0016] Adjust the VV interval of the CRT according to the initial adjustment amount and initial adjustment direction of the CRT;

[0017] Based on the adjusted first ratio and second ratio, the optimization direction is determined;

[0018] The VV interval of the CRT is adjusted sequentially in the optimization direction until the first ratio is less than the first threshold and the second ratio is less than the second threshold.

[0019] In conjunction with the first aspect, in one embodiment, the adjustment magnitude of the VV interval of the CRT is gradually reduced when the first ratio is less than the first threshold and the second ratio is less than the second threshold in the optimization direction.

[0020] In conjunction with the first aspect, in one embodiment, the process of successively adjusting the VV interval of the CRT in the optimization direction until the first ratio is less than the first threshold and the second ratio is less than the second threshold, wherein each adjustment of the VV interval of the CRT includes the following steps:

[0021] The adjustment amount of the VV interval of CRT is determined based on the difference between the first ratio and the first threshold and / or the difference between the second ratio and the second threshold.

[0022] The VV interval of the CRT is adjusted according to the adjustment amount.

[0023] In conjunction with the first aspect, in one embodiment, obtaining the target total QRS duration, the first time difference from the QRS initiation to the near-basic tortuosity in the precordial leads V2 and V5, and the second time difference from the QRS initiation to the near-basic tortuosity in the limb lead aVL, based on the electrocardiogram data, includes the following steps:

[0024] Based on the electrocardiogram data, determine the total QRS duration of the target.

[0025] The electrocardiogram (ECG) data is magnified, and based on the magnified ECG data, the first time difference from the QRS initiation to the in-situ tortuosity of the precordial leads V2 and V5, and the second time difference from the QRS initiation to the in-situ tortuosity of the limb lead aVL are determined.

[0026] Secondly, embodiments of this application provide a CRT VV interval optimization device, which adopts the following technical solution:

[0027] A VV interval optimization device for a CRT, the CRT VV interval optimization device comprising:

[0028] The acquisition module is configured to acquire the electrocardiogram data of the target.

[0029] The calculation module is configured to obtain the target total QRS time, the first time difference from the QRS wave initiation to the stereotyped tortuosity in the precordial leads V2 and V5, and the second time difference from the QRS wave initiation to the stereotyped tortuosity in the limb lead aVL based on the electrocardiogram data.

[0030] The judgment module is configured to determine whether the contraction synchronicity of the target heart needs to be optimized based on a first ratio of the first time difference to the total QRS time and a second ratio of the second time difference to the total QRS time.

[0031] An optimization module is configured to optimize the VV interval of the CRT in a direction that reduces the first ratio and the second ratio if optimization is required.

[0032] In conjunction with the second aspect, in one implementation, the computing module includes:

[0033] An amplification unit configured to amplify the electrocardiogram data;

[0034] The identification unit is configured to identify the start and end positions of the QRS wave in the electrocardiogram, identify the start position and quasi-basal tortuosity of the QRS wave in the precordial V2 and V5 leads in the magnified electrocardiogram data, and identify the start position and quasi-basal tortuosity of the QRS wave in the limb lead aVL.

[0035] The processing unit is configured to determine the total QRS duration of the target based on the electrocardiogram data, and to determine the first time difference from the QRS initiation to the inverted tortuosity of the precordial leads V2 and V5, and the second time difference from the QRS initiation to the inverted tortuosity of the limb lead aVL, based on the amplified electrocardiogram data.

[0036] Thirdly, embodiments of this application provide a CRT VV interval optimization device, which adopts the following technical solution:

[0037] A VV interval optimization device for a CRT includes a processor, a memory, and a VV interval optimization program for the CRT stored in the memory and executable by the processor. When the VV interval optimization program for the CRT is executed by the processor, it implements the steps of the VV interval optimization method for the CRT as described above.

[0038] Fourthly, embodiments of this application provide a storage medium, employing the following technical solution:

[0039] A storage medium storing a VV interval optimization program for a CRT, wherein when the VV interval optimization program for the CRT is executed by a processor, the steps of the VV interval optimization method for the CRT as described above are implemented.

[0040] The beneficial effects of the technical solutions provided in this application include:

[0041] By obtaining the first time difference from the onset of the QRS wave to the near-basal tortuosity in the target precordial leads V2 and V5 (i.e., the depolarization onset time difference between the left and right ventricles) and the second time difference from the onset of the QRS wave to the near-basal tortuosity in the limb leads aVL and aVF (i.e., the depolarization onset time difference between the inferior and lateral walls of the left ventricle), the ratio of these two time differences to the total QRS duration is compared to indicate the synchronicity of the current cardiac contraction. When the synchronicity is poor, the VV interval of the CRT needs to be optimized to effectively improve the synchronicity of cardiac contraction. Ultimately, the VV parameters of the CRT can be optimized using a routine twelve-lead ECG, improving the value of ECG examination and the efficiency of CRT optimization. Attached Figure Description

[0042] Figure 1 This is a flowchart illustrating an embodiment of the VV interval optimization method for CRT in this application;

[0043] Figure 2 This is a functional block diagram of an embodiment of the VV interval optimization device of the CRT of this application;

[0044] Figure 3 This is a schematic diagram of the hardware structure of the CRT VV interval optimization device involved in the embodiments of this application. Detailed Implementation

[0045] To enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present application, and not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present application.

[0046] Currently, echocardiography-guided parameter optimization is widely used; however, its clinical application is limited due to its time-consuming nature, high cost, and poor patient compliance. Measuring the QRS width in a standard electrocardiogram (ECG) to guide CRT parameter optimization, with the VV interval at the narrowest QRS complex as the optimal treatment parameter, is relatively simple, quick, and inexpensive compared to echocardiography. However, because the QRS width is influenced by multiple factors, it cannot accurately reflect the synchronization of left and right ventricular contractions and myocardial contraction within the left ventricle, thus its specificity is not high. Therefore, finding a time-efficient, easy-to-operate, inexpensive, and highly specific method to optimize CRT patients' treatment parameters is particularly necessary.

[0047] To address the aforementioned issues, this application provides a method, apparatus, device, and storage medium for optimizing the VV interval of a cardiac arrestor (CRT). The key aspect of this invention lies in acquiring the first time difference between the QRS initiation and near-basic tortuosity of the target precordial leads V2 and V5 (i.e., the depolarization initiation time difference between the left and right ventricles) and the second time difference between the QRS initiation and near-basic tortuosity of the limb leads aVL and aVF (i.e., the depolarization initiation time difference between the inferior and lateral walls of the left ventricle) using electrocardiogram (ECG) data. By comparing the ratio of these two time differences to the total QRS duration, the synchronicity of current cardiac contraction can be accurately determined. When synchronicity is poor, the VV interval of the CRT needs to be optimized to effectively improve cardiac contraction synchronicity. Ultimately, this allows for the optimization of CRT VV parameters using a conventional twelve-lead ECG, enhancing the value of ECG examination and the efficiency of CRT optimization.

[0048] To make the objectives, technical solutions, and advantages of this application clearer, the embodiments of this application will be described in further detail below with reference to the accompanying drawings.

[0049] In a first aspect, embodiments of this application provide a method for optimizing the VV interval of a CRT.

[0050] In one embodiment, reference is made to Figure 1 , Figure 1 This is a flowchart illustrating the first embodiment of the VV interval optimization method for CRT in this application. Figure 1 As shown, the CRT VV interval optimization methods include:

[0051] S100, Obtain the target's electrocardiogram data;

[0052] Specifically, the electrocardiogram (ECG) data refers to a standard 12-lead ECG, which can be retrieved from the ECG machine after being tested by the relevant ECG machine.

[0053] S200. Based on the electrocardiogram data, obtain the target total QRS duration, the first time difference from the QRS wave initiation to the in-situ tortuosity of the precordial leads V2 and V5, and the second time difference from the QRS wave initiation to the in-situ tortuosity of the limb lead aVL.

[0054] Specifically, in some implementations, step S200 includes the following steps:

[0055] S210. Determine the total QRS duration of the target based on the electrocardiogram data;

[0056] S220. Amplify the electrocardiogram data, and determine the first time difference (V5ID-V1ID) from the QRS initiation to the in-situ tortuosity of the precordial leads V2 and V5, and the second time difference (aVLID-aVFID) from the QRS initiation to the in-situ tortuosity of the limb lead aVL.

[0057] S300. Based on the first ratio of the first time difference to the total QRS time ([V5ID-V1ID] / QRSd (%)) and the second ratio of the second time difference to the total QRS time ([aVLID-aVFID] / QRSd (%)), determine whether the contraction synchronicity of the target heart needs to be optimized.

[0058] Specifically, in some embodiments, step S300 includes the following steps:

[0059] S310. Determine whether the first ratio is greater than the first threshold and whether the second ratio is greater than the second threshold;

[0060] S320. If the first ratio is greater than the first threshold or the second ratio is greater than the second threshold, then the contraction synchronicity of the target heart needs to be optimized; otherwise, no optimization is needed.

[0061] In this embodiment, the first threshold and the second threshold are preferably the same threshold parameter, such as 25%. Therefore, when both the first ratio and the second ratio are >25%, it indicates that the synchronicity of cardiac contraction is poor, and CRT VV interval optimization is required. Conversely, it indicates that the synchronicity of cardiac contraction meets the relevant requirements and no optimization is needed.

[0062] S400. If optimization is required, optimize the VV interval of the CRT in the direction of reducing the first ratio and the second ratio.

[0063] Specifically, in some embodiments, step S400 includes the following steps:

[0064] S410. Adjust the VV interval of the CRT according to the initial adjustment amount and initial adjustment direction of the set VV interval of the CRT;

[0065] The initial adjustment direction is the preset increase / decrease of the VV interval by relevant technical personnel, and the initial adjustment amount is the adjustment amount for increasing / decreases the VV interval. By setting the initial adjustment direction and initial adjustment amount, it is determined which direction the current VV interval should be adjusted in to optimize the synchronicity of cardiac contraction.

[0066] S420. Determine the optimization direction based on the first ratio and the second ratio obtained after adjustment; for example, if the first ratio and the second ratio obtained after adjustment decrease, it means that the current adjustment direction can help the heart to contract synchronously, and the current adjustment direction is the optimization direction; otherwise, it means that it does not help the heart to contract synchronously, and the opposite adjustment direction is taken as the optimization direction.

[0067] S430. The VV interval of the CRT is adjusted sequentially in the optimization direction until the first ratio is less than the first threshold and the second ratio is less than the second threshold. By sequentially adjusting the VV interval of the CRT, the cardiac contraction can be gradually adjusted to a suitable synchronization state, avoiding the impact on cardiac contraction when the adjustment is too large at one time.

[0068] Furthermore, in some embodiments, in step S430, the adjustment range of the VV interval of the CRT is gradually reduced in the process of successively adjusting the CRT VV interval in the optimization direction until the first ratio is less than the first threshold and the second ratio is less than the second threshold.

[0069] This setting allows for more accurate optimization of the VV interval of the CRT in the direction of synchronized cardiac contraction, ultimately adjusting the VV interval to a range that meets the requirements for synchronized cardiac contraction.

[0070] Specifically, step S430 involves successively adjusting the VV interval of the CRT in the optimization direction until the first ratio is less than the first threshold and the second ratio is less than the second threshold. Each adjustment of the VV interval of the CRT includes the following steps:

[0071] S431. Determine the adjustment amount of the VV interval of CRT based on the difference between the first ratio and the first threshold and / or the difference between the second ratio and the second threshold.

[0072] S432. Adjust the VV interval of the CRT according to the adjustment amount.

[0073] In this embodiment, the adjustment amount is positively correlated with the difference between the first ratio and the first threshold and the difference between the second ratio and the second threshold. That is, when the difference between the first ratio and the first threshold is large, a larger adjustment amount is used to adjust the VV interval of CRT, so that the cardiac contraction synchronicity can be brought closer to the required synchronous state as soon as possible within a suitable adjustment range. When the difference between the first ratio and the second threshold is small, a relatively small adjustment amount is used to adjust, so that the cardiac contraction synchronicity can be stably approached to the optimal state of synchronous cardiac contraction, avoiding the situation where excessive subsequent adjustments cause the cardiac contraction synchronicity to become worse.

[0074] Finally, by obtaining the first time difference from the QRS initiation to the near-basal tortuosity in the target precordial leads V2 and V5 (i.e., the depolarization initiation time difference between the left and right ventricles) and the second time difference from the QRS initiation to the near-basal tortuosity in the limb leads aVL and aVF (i.e., the depolarization initiation time difference between the inferior and lateral walls of the left ventricle), the ratio of these two time differences to the total QRS duration is compared to assess the synchronicity of current cardiac contraction. When synchronicity is poor, the VV interval of the CRT needs to be optimized to effectively improve the synchronicity of cardiac contraction. This allows for the optimization of CRT VV parameters using a standard 12-lead ECG, improving the value of ECG examination and the efficiency of CRT optimization.

[0075] The method provided in this case for optimizing the VV parameters of CRT using the first and second time differences obtained from a conventional 12-lead electrocardiogram is compared with the existing method for optimizing the VV parameters of CRT using ultrasound parameters. The effects of the two methods on the cardiac function (LVEF) of multiple sample patients after optimization are shown in Tables 1 and 2:

[0076] Table 1: Comparison of cardiac function before and after ultrasound optimization

[0077]

[0078] Table 2: Comparison of cardiac function before and after optimization in this case

[0079]

[0080] As shown in Tables 1 and 2, the method used in this study to optimize the VV parameters of CRT using the first and second time differences obtained from a conventional 12-lead electrocardiogram (ECG) has no significant difference in its impact on cardiac function compared to the existing method using ultrasound parameters. Furthermore, it can be seen that when the sample patients had poor cardiac function, the optimized method provided in this study resulted in better cardiac function. Further analysis of the data used in this study, which is based on a conventional 12-lead ECG, demonstrates that the proposed CRT VV interval optimization method is more convenient to operate and has better control effects when used clinically.

[0081] Secondly, embodiments of this application also provide a CRT VV interval optimization device.

[0082] In one embodiment, reference is made to Figure 2 , Figure 2 This is a functional block diagram of an embodiment of the VV interval optimization device for the CRT of this application. Figure 2 As shown, the VV interval optimization device of the CRT includes:

[0083] The acquisition module is configured to acquire the electrocardiogram data of the target.

[0084] The calculation module is configured to obtain the target total QRS time, the first time difference from the QRS wave initiation to the stereotyped tortuosity in the precordial leads V2 and V5, and the second time difference from the QRS wave initiation to the stereotyped tortuosity in the limb lead aVL based on the electrocardiogram data.

[0085] The judgment module is configured to determine whether the contraction synchronicity of the target heart needs to be optimized based on a first ratio of the first time difference to the total QRS time and a second ratio of the second time difference to the total QRS time.

[0086] An optimization module is configured to optimize the VV interval of the CRT in a direction that reduces the first ratio and the second ratio if optimization is required.

[0087] Furthermore, in one embodiment, the computing module includes:

[0088] An amplification unit configured to amplify the electrocardiogram data;

[0089] The identification unit is configured to identify the start and end positions of the QRS wave in the electrocardiogram, identify the start position and quasi-basal tortuosity of the QRS wave in the precordial V2 and V5 leads in the magnified electrocardiogram data, and identify the start position and quasi-basal tortuosity of the QRS wave in the limb lead aVL.

[0090] The processing unit is configured to determine the target total QRS duration based on the electrocardiogram (ECG) data, and to determine the first time difference between the QRS initiation and near-basic tortuosity of the precordial V2 and V5 leads, and the second time difference between the QRS initiation and near-basic tortuosity of the limb lead aVL, based on the amplified ECG data. The functional implementation of each module in the aforementioned CRT VV interval optimization device corresponds to the steps in the aforementioned CRT VV interval optimization method embodiment; their functions and implementation processes will not be elaborated upon here.

[0091] Thirdly, embodiments of this application provide a VV interval optimization device for a CRT. The VV interval optimization device for a CRT can be a device with data processing capabilities, such as a personal computer (PC), a laptop computer, or a server.

[0092] Reference Figure 3 , Figure 3 This is a schematic diagram of the hardware structure of the CRT VV interval optimization device involved in the embodiments of this application. In the embodiments of this application, the CRT VV interval optimization device may include a processor, a memory, a communication interface, and a communication bus.

[0093] The communication bus can be of any type and is used to interconnect the processor, memory, and communication interface.

[0094] The communication interface includes input / output (I / O) interfaces, physical interfaces, and logical interfaces used for interconnecting devices within the CRT's VV-interval optimization device, as well as interfaces used for interconnecting the CRT's VV-interval optimization device with other devices (such as other computing devices or user equipment). Physical interfaces can be Ethernet interfaces, fiber optic interfaces, ATM interfaces, etc.; user equipment can be displays, keyboards, etc.

[0095] Memory can be various types of storage media, such as random access memory (RAM), read-only memory (ROM), non-volatile RAM (NVRAM), flash memory, optical storage, hard disk, programmable ROM (PROM), erasable PROM (EPROM), electrically erasable PROM (EEPROM), etc.

[0096] The processor can be a general-purpose processor, which can call the VV interval optimization program of the CRT stored in memory and execute the VV interval optimization method of the CRT provided in the embodiments of this application. For example, the general-purpose processor can be a central processing unit (CPU). The method executed when the VV interval optimization program of the CRT is called can refer to the various embodiments of the VV interval optimization method of the CRT in this application, and will not be repeated here.

[0097] Those skilled in the art will understand that Figure 3 The hardware structure shown does not constitute a limitation of this application and may include more or fewer components than shown, or combine certain components, or have different component arrangements.

[0098] Fourthly, embodiments of this application also provide a storage medium.

[0099] The present application stores a CRT VV interval optimization program on the storage medium, wherein when the CRT VV interval optimization program is executed by the processor, the steps of the CRT VV interval optimization method described above are implemented.

[0100] The method implemented when the VV interval optimization procedure of CRT is executed can be referred to in various embodiments of the VV interval optimization method of CRT in this application, and will not be repeated here.

[0101] It should be noted that the sequence numbers of the embodiments in this application are for descriptive purposes only and do not represent the superiority or inferiority of the embodiments.

[0102] The terms "comprising" and "having," and any variations thereof, in the specification, claims, and accompanying drawings of this application are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to such process, method, product, or apparatus. The terms "first," "second," and "third," etc., are used to distinguish different objects, etc., and do not indicate a sequence, nor do they limit "first," "second," and "third" to different types.

[0103] In the description of the embodiments of this application, terms such as "exemplary," "for example," or "for instance" are used to indicate examples, illustrations, or explanations. Any embodiment or design described as "exemplary," "for example," or "for instance" in the embodiments of this application should not be construed as being more preferred or advantageous than other embodiments or designs. Specifically, the use of terms such as "exemplary," "for example," or "for instance" is intended to present the relevant concepts in a concrete manner.

[0104] In the description of the embodiments of this application, unless otherwise stated, " / " means "or". For example, A / B can mean A or B. The "and / or" in the text is merely a description of the relationship between related objects, indicating that there can be three relationships. For example, A and / or B can mean: A exists alone, A and B exist simultaneously, and B exists alone. In addition, in the description of the embodiments of this application, "multiple" means two or more.

[0105] In some processes described in the embodiments of this application, multiple operations or steps are included in a specific order. However, it should be understood that these operations or steps may not be executed in the order they appear in the embodiments of this application, or they may be executed in parallel. The sequence number of the operation is only used to distinguish different operations, and the sequence number itself does not represent any execution order. In addition, these processes may include more or fewer operations, and these operations or steps may be executed sequentially or in parallel, and these operations or steps may be combined.

[0106] Through the above description of the embodiments, those skilled in the art can clearly understand that the methods of the above embodiments can be implemented by means of software plus necessary general-purpose hardware platforms. Of course, they can also be implemented by hardware, but in many cases the former is a better implementation method. Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, can be embodied in the form of a software product. This computer software product is stored in a storage medium (such as ROM / RAM, magnetic disk, optical disk) as described above, and includes several instructions to cause a terminal device to execute the methods described in the various embodiments of this application.

[0107] The above are merely preferred embodiments of this application and do not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A CRT VV interval optimization device, characterized in that, The VV interval optimization device of the CRT includes: The acquisition module is configured to acquire the electrocardiogram data of the target. The calculation module is configured to obtain the target total QRS time, the first time difference from the QRS wave initiation to the stereotyped tortuosity in the precordial leads V2 and V5, and the second time difference from the QRS wave initiation to the stereotyped tortuosity in the limb lead aVL based on the electrocardiogram data. The judgment module is configured to determine whether the contraction synchronicity of the target heart needs to be optimized based on a first ratio of the first time difference to the total QRS time and a second ratio of the second time difference to the total QRS time. An optimization module is configured to optimize the VV interval of the CRT in a direction that reduces the first ratio and the second ratio if optimization is required. The judgment module is specifically configured as follows: Determine whether the first ratio is greater than a first threshold and whether the second ratio is greater than a second threshold; If the first ratio is greater than the first threshold or the second ratio is greater than the second threshold, then the contraction synchronicity of the target heart needs to be optimized; otherwise, no optimization is needed.

2. The CRT VV interval optimization device as described in claim 1, characterized in that, The optimization module is specifically configured as follows: Adjust the VV interval of the CRT according to the initial adjustment amount and initial adjustment direction of the CRT; Based on the adjusted first ratio and second ratio, the optimization direction is determined; The VV interval of the CRT is adjusted sequentially in the optimization direction until the first ratio is less than the first threshold and the second ratio is less than the second threshold.

3. The CRT VV interval optimization device as described in claim 2, characterized in that, The optimization module is further configured to: The VV interval of the CRT is adjusted successively in the optimization direction until the first ratio is less than the first threshold and the second ratio is less than the second threshold. The adjustment range of the VV interval of the CRT is gradually reduced in the multiple adjustments.

4. The CRT VV interval optimization device as described in claim 3, characterized in that, The optimization module is further configured to: The adjustment amount of the VV interval of CRT is determined based on the difference between the first ratio and the first threshold and / or the difference between the second ratio and the second threshold. The VV interval of the CRT is adjusted according to the adjustment amount.

5. The CRT VV interval optimization device as described in claim 1, characterized in that, The computing module includes: An amplification unit configured to amplify the electrocardiogram data; The identification unit is configured to identify the start and end positions of the QRS wave in the electrocardiogram, identify the start position and quasi-basal tortuosity of the QRS wave in the precordial V2 and V5 leads in the magnified electrocardiogram data, and identify the start position and quasi-basal tortuosity of the QRS wave in the limb lead aVL. The processing unit is configured to determine the total QRS duration of the target based on the electrocardiogram data, and to determine the first time difference from the QRS initiation to the inverted tortuosity of the precordial leads V2 and V5, and the second time difference from the QRS initiation to the inverted tortuosity of the limb lead aVL, based on the amplified electrocardiogram data.

6. A CRT VV interval optimization device, characterized in that, The CRT VV interval optimization device includes a processor, a memory, and a CRT VV interval optimization program stored in the memory and executable by the processor. When the CRT VV interval optimization program is executed by the processor, it implements a CRT VV interval optimization method, the method comprising: Obtain the target's electrocardiogram data; Based on the electrocardiogram data, the total QRS duration of the target, the first time difference from the QRS wave initiation to the in-situ tortuosity in the precordial leads V2 and V5, and the second time difference from the QRS wave initiation to the in-situ tortuosity in the limb lead aVL are obtained. Based on a first ratio of the first time difference to the total QRS time and a second ratio of the second time difference to the total QRS time, it is determined whether the contraction synchronicity of the target heart needs to be optimized, including the following steps: determining whether the first ratio is greater than a first threshold and whether the second ratio is greater than a second threshold; if the first ratio is greater than the first threshold or the second ratio is greater than the second threshold, then the contraction synchronicity of the target heart needs to be optimized; otherwise, optimization is not required. If optimization is needed, optimize the VV interval of CRT by reducing the first ratio and the second ratio.

7. A storage medium, characterized in that, The storage medium stores a VV interval optimization program for the CRT, wherein when the CRT VV interval optimization program is executed by the processor, the steps of implementing the CRT VV interval optimization method are as follows: Obtain the target's electrocardiogram data; Based on the electrocardiogram data, the total QRS duration of the target, the first time difference from the QRS wave initiation to the in-situ tortuosity in the precordial leads V2 and V5, and the second time difference from the QRS wave initiation to the in-situ tortuosity in the limb lead aVL are obtained. Based on a first ratio of the first time difference to the total QRS time and a second ratio of the second time difference to the total QRS time, it is determined whether the contraction synchronicity of the target heart needs to be optimized, including the following steps: determining whether the first ratio is greater than a first threshold and whether the second ratio is greater than a second threshold; if the first ratio is greater than the first threshold or the second ratio is greater than the second threshold, then the contraction synchronicity of the target heart needs to be optimized; otherwise, optimization is not required. If optimization is needed, optimize the VV interval of CRT by reducing the first ratio and the second ratio.

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