Preparation method of composition with soothing and repairing functions

Abstract

The invention relates to a preparation method of a composition with soothing and repairing functions. The preparation method comprises the following steps: stirring and mixing aesculus chinensis fruits, feverfew, oat bran, mangnolia officinalis bark and radix stephaniae tetrandrae, drying, crushing and sieving to obtain mixed powder; adding an ethanol aqueous solution into the mixed powder, heating, refluxing, extracting, filtering, collecting an extracting solution, and extracting residues for the second time; combining the two extracting solutions, and concentrating into paste; dissolving the concentrated paste with hot water, adsorbing with modified D101 macroporous adsorption resin, loading the modified D101 macroporous adsorption resin into a chromatographic column, eluting, collecting an ethanol water eluent, concentrating and drying to obtain a plant composition mixed extract; the preparation method comprises the following steps: taking a plant composition mixed extract, adding the plant composition mixed extract into polyhydric alcohol, heating and stirring until the plant composition mixed extract is completely dissolved, adding water in batches, stirring while adding until the solution is clear and transparent, and filtering by using a 0.22 mu m filter membrane to obtain the composition with the soothing and repairing functions.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to a method for preparing a composition with soothing and repairing functions. Background Art

[0002] Sensitive skin is a sub-healthy skin condition, which refers to the subjective abnormal sensation caused by the skin's high sensitivity to multiple external factors, including: itching, burning, stinging, tightness, desquamation and other discomforts, and can also manifest as erythema, papules, scales, thin epidermis, capillary dilation, etc. Tolerance to external stimuli such as skin care products, climate, temperature, and contact objects is reduced. At present, with the improvement of people's understanding of sensitive skin and the development of skin care products and medical beauty technology, this syndrome has received more and more attention. Sensitive skin can be improved by restoring the skin barrier function, reducing skin sensitivity and inflammatory response, and improving skin tolerance. Therefore, daily skin care should choose anti-inflammatory, anti-allergic, mild and non-irritating skin care products to improve skin redness, swelling, pain, itching and other symptoms, so as to restore the skin to a healthy state.

[0003] Chinese patent CN116850114A: relates to the field of cosmetic technology, specifically discloses a soothing repair composition and a soothing repair lotion and a preparation method thereof. A soothing repair composition comprises the following components: 3% to 8% magnesium ascorbyl phosphate, 1% to 5% filtrate of callus culture of Eryngium marinum, 1% to 5% extract of sempervivum sempervivum, 1% to 5% extract of root of Ruscus rubra, and the balance is solvent. A soothing repair lotion comprises a moisturizer, a thickener, a chelating agent, an emulsifier, an emollient, p-hydroxyacetophenone, hexylene glycol, a soothing repair composition, and water.

[0004] Chinese patent CN117503664A: discloses a soothing and repairing composition, which is a nanolipid inclusion made of phase A and phase B. Phase A is a soothing and repairing component, which includes bletilla striata root extract, ginseng root extract, ceramide NP, gentiana root extract, Centella asiatica leaf extract and tetrahydromethylpyrimidine carboxylic acid, and the weight percentage content of each raw material component is limited.

[0005] Chinese Patent CN111920728A: Provides a cosmetic soothing and repairing composition and cosmetics, the soothing and repairing composition comprising the following components in parts by weight: 5-20 parts of peppermint leaf extract, 0.5-3 parts of geranium extract, 1-5 parts of golden chamomile extract, 2-10 parts of sophora flavescens root extract, 2-10 parts of purslane extract and 3-8 parts of aloe vera extract.

[0006] The compositions with soothing and repairing functions prepared by the above patents and prior arts mainly use natural plant raw materials such as licorice, purslane, rhubarb, salvia miltiorrhiza, chuanxiong, angelica, Panax notoginseng, ginseng, eucommia, Centella asiatica, scutellaria, sophora flavescens, etc., which have problems such as poor soothing effect and unsatisfactory deep repair effect. Summary of the invention

[0007] In order to solve the above problems, the present invention provides a method for preparing a composition with soothing and repairing functions, and the operating steps are as follows:

[0008] S1: according to weight, 5-20 parts of horse chestnut fruit, 5-20 parts of feverfew chrysanthemum, 5-20 parts of oat bran, 5-20 parts of Magnolia officinalis bark, and 5-20 parts of Stephania tetrandra root are stirred and mixed, dried, crushed, and passed through a 40-mesh sieve to obtain a mixed powder;

[0009] S2: Add 500-1000 parts of ethanol aqueous solution to the mixed powder, adjust the pH value with glacial acetic acid, heat and reflux for extraction for 1.5-3h, filter, collect the extract, and extract the residue for the second time;

[0010] S3: Add 300-600 parts of ethanol aqueous solution to the residue after extraction, adjust the pH value with concentrated ammonia water, heat and reflux for extraction for 1.5-3h, filter and collect the extract;

[0011] S4: Combine the two extracts and concentrate to a paste;

[0012] S5: dissolving the concentrated paste with hot water, adjusting the pH to 7-8 with concentrated ammonia water, adsorbing with modified D101 macroporous adsorption resin, loading the modified D101 macroporous adsorption resin into a chromatography column, eluting with 5-10 column volumes of pure water, and then eluting with 3-8 column volumes of ethanol aqueous solution, collecting the ethanol aqueous eluate, concentrating, and drying to obtain a mixed extract of the plant composition;

[0013] S6: Take 0.1-1 parts of the mixed extract of the plant composition, add it to 40-60 parts of polyol, heat and stir until completely dissolved, add a total of 40-80 parts of water in 5-8 times, stirring while adding until the solution is clear and transparent, filter with a 0.22μm filter membrane to obtain a composition with soothing and repairing functions.

[0014] The mass concentration of the ethanol aqueous solution is 50-80%.

[0015] The pH value of S2 is adjusted to 3.5-6.5.

[0016] The pH value of S3 is adjusted to 7.5-10.5.

[0017] The adsorption time of S5 is 20-24h.

[0018] The polyol is one of butanediol, propylene glycol, glycerol, pentanediol and hexanediol.

[0019] The preparation method of the modified D101 macroporous adsorption resin comprises the following steps:

[0020] The D101 macroporous adsorption resin is sent into a radio frequency plasma generator for functional group modification; it is spread evenly on a porcelain boat and placed in the radio frequency plasma generator; under the condition of a power of 100W-300W, ammonia, piceatannol and 2-pyrazinylethanethiol vapor are mixed in a volume ratio and then introduced into a plasma chamber; the gas flow rate is controlled within the range of 20-50mL / min; the D101 macroporous adsorption resin is treated with a plasma with a frequency of 13.56MHz for 15-25 minutes; after the treatment is completed, the modified D101 macroporous adsorption resin is taken out to obtain.

[0021] The ammonia, piceatannol and 2-pyrazinylethanethiol are mixed in a volume ratio of 1: (0.2-0.6): (0.001-0.02) and then introduced into the plasma chamber.

[0022] Reaction mechanism

[0023] 1. Plasma-induced reaction: In a plasma environment, the double bonds in 2-pyrazinylethanethiol vapor are activated to form highly active free radicals or ions; these highly active species react with the functional groups on the surface of the D101 macroporous adsorption resin, successfully introducing the thiol group (-SH) into the resin structure.

[0024] 2. Ammonia catalytic addition: Under the catalytic action of ammonia, the D101 macroporous adsorption resin introduced with thiol undergoes an addition reaction with the carbon-carbon double bond in the piceatannol vapor; this step is a nucleophilic addition reaction between the thiol and the double bond in the piceatannol to form a new chemical bond.

[0025] 3. Formation of grafted piceatannol: Through the above addition reaction, the D101 macroporous adsorption resin grafted with piceatannol and 2-pyrazinyl is finally obtained; this new resin material combines the biological activity of piceatannol and the special properties of 2-pyrazinyl, and may have more excellent performance and application prospects.

[0026] Technical Effects

[0027] The present invention provides a method for preparing a composition with soothing and repairing functions. Compared with the prior art, the present invention has the following significant effects:

[0028] 1. Selective adsorption: D101 macroporous adsorption resin has a strong selective adsorption capacity for natural active ingredients in plant extracts (such as flavonoids, saponins, terpenes, etc.); this is because these compounds usually have a large molecular weight and specific functional groups, which can form hydrogen bonds, van der Waals forces or other non-covalent interactions with the functional groups on the resin surface.

[0029] 2. Physical sieving effect: The porous structure of the macroporous adsorption resin provides a large specific surface area and abundant adsorption sites, making it difficult for impurities in the extract (such as inorganic salts, small molecular organic matter, etc.) to enter the interior of the resin, thereby achieving the purification and enrichment of the active ingredients.

[0030] 3. Improve stability and efficacy: The extract purified and enriched by D101 macroporous adsorption resin has a significantly increased content of natural active ingredients, while removing most impurities and harmful substances, thereby improving the stability of the extract and the efficacy of the raw materials; this purification process helps to retain the bioactive ingredients in the extract and reduce their degradation and loss during storage and use. DETAILED DESCRIPTION

[0031] In order to further explain the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following is a detailed description in combination with embodiments and comparative examples:

[0032] 1. Anti-inflammatory effect

[0033] The xylene-induced mouse ear swelling model was used to evaluate the anti-inflammatory effect of the product, and the swelling inhibition rate and the inhibition rate of the release of inflammatory factors IL-6, TNF-α, and PGE2 were determined.

[0034] The experimental mice were smeared with 50 μL of xylene on the back of the left ear with a microsyringe to induce inflammation. 0.1 mL of the corresponding drug was applied to the right ear 2h, 1h before inflammation, and 2h after inflammation: model group (0.9% sodium chloride solution), experimental group (skin care raw materials). 3h after inflammation, the ears were cleaned and dried. The mice were killed after cutting off the tail and taking blood. The ears were cut off and aligned. A puncher with a diameter of about 0.6 cm was used to punch the tissue block at the same position between the left and right ears of the mice and weighed. The swelling was calculated. After the blood was left to stand at 4°C overnight, the serum was separated at 3500r / min, 10min, and 4°C. The ELISA kit was used to detect the content of IL-6, TNF-α, and PGE2 in the serum.

[0035] The degree of swelling = right ear weight (mg) - left ear weight (mg) was used as an indicator of the intensity of the inflammatory reaction.

[0036] Swelling inhibition rate = swelling degree of model group - swelling degree of experimental group / swelling degree of model group × 100%.

[0037] Inflammatory factor release inhibition rate = inflammatory factor content in model group - inflammatory factor content in experimental group / inflammatory factor content in model group × 100%.

[0038] 2. Analgesic effect

[0039] The hot plate pain experimental model was used to evaluate the analgesic effect of the product and determine the percentage increase in pain threshold. Under room temperature, the mice were placed on a (55±0.5)℃ hot plate, and the time from contacting the hot plate to licking the hind paw was taken as the pain threshold; mice with pain thresholds of <3s and >30s were eliminated. The pain threshold of the mice was measured twice before administration, and the average value was taken as the pre-dose (basal) pain threshold. 1mL of skin care raw materials were applied to the soles of the mice, and the pain thresholds of the mice were observed and recorded after 15 minutes, and the percentage increase in the pain threshold of the mice before and after administration was calculated.

[0040] The percentage increase of pain threshold = pain threshold after drug administration - pain threshold before drug administration / pain threshold before drug administration × 100%.

[0041] 3. Antipruritic effect

[0042] The experimental model of local pruritus reaction caused by histamine in guinea pigs was used to determine the percentage increase of the itch threshold. The dorsum of the right hind foot of the guinea pig was shaved, and the shaved area of ​​the guinea pig was gently scratched with coarse sandpaper to form an epidermal damage wound with an area of ​​1cm×1cm. 0.1mL 0.9% sodium chloride solution was applied to the wound in the blank control group, and 0.1mL skin care raw materials were applied to the wound in the experimental group. 0.01% histamine phosphate was dripped on the wound 30min after administration 0.05mL / pig, and then the concentration was increased by 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, and 0.1% every 3min until the guinea pig turned back and licked its hind foot. The total amount of histamine phosphate used by each guinea pig in each group (μg) was the itch threshold.

[0043] The percentage of increase in itch threshold = itch threshold of experimental group - itch threshold of blank control group / itch threshold of blank control group × 100%.

[0044] Example 1

[0045] A method for preparing a composition with soothing and repairing functions, the operating steps are:

[0046] S1: 5 g of horse chestnut fruit, 5 g of feverfew, 5 g of oat bran, 5 g of Magnolia officinalis bark, and 5 g of Stephania tetrandra root were stirred, dried, crushed, and passed through a 40-mesh sieve to obtain a mixed powder;

[0047] S2: Add 500 g of ethanol aqueous solution to the mixed powder, adjust the pH value with glacial acetic acid, heat and reflux for extraction for 1.5 h, filter, collect the extract, and perform a second extraction on the residue;

[0048] S3: Add 300 g of ethanol aqueous solution to the residue after extraction, adjust the pH value with concentrated ammonia water, heat and reflux for extraction for 1.5 h, filter and collect the extract;

[0049] S4: Combine the two extracts and concentrate to a paste;

[0050] S5: dissolving the concentrated paste with hot water, adjusting the pH to 7 with concentrated ammonia water, adsorbing with modified D101 macroporous adsorption resin, loading the modified D101 macroporous adsorption resin into a chromatography column, eluting with 5 column volumes of pure water, and then eluting with 3 column volumes of ethanol aqueous solution, collecting the ethanol aqueous eluate, concentrating, and drying to obtain a mixed extract of the plant composition;

[0051] S6: Take 0.1g of the mixed extract of the plant composition, add it to 40g of polyol, heat and stir until completely dissolved, add a total of 40g of water in 5 times, stirring while adding until the solution is clear and transparent, filter with a 0.22μm filter membrane to obtain a composition with soothing and repairing functions.

[0052] The mass concentration of the ethanol aqueous solution is 50%.

[0053] The pH value of S2 was adjusted to 3.5.

[0054] The pH value of S3 was adjusted to 7.5.

[0055] The adsorption time of S5 is 20h.

[0056] The polyol is butanediol.

[0057] The preparation method of the modified D101 macroporous adsorption resin comprises the following steps:

[0058] The D101 macroporous adsorption resin is sent into a radio frequency plasma generator for functional group modification; it is spread evenly on a porcelain boat and placed in the radio frequency plasma generator; under the condition of a power of 100 W, ammonia, piceatannol and 2-pyrazinylethanethiol vapor are mixed in a volume ratio and then introduced into the plasma chamber; the gas flow rate is controlled within the range of 20 mL / min; the D101 macroporous adsorption resin is treated with a plasma with a frequency of 13.56 MHz for 15 minutes; after the treatment is completed, the modified D101 macroporous adsorption resin is taken out to obtain.

[0059] The ammonia, piceatannol and 2-pyrazinylethanethiol are mixed in a volume ratio of 1:0.2:0.001 and then introduced into the plasma chamber.

[0060] Example 2

[0061] A method for preparing a composition with soothing and repairing functions, the operating steps are:

[0062] S1: 10 g of horse chestnut fruit, 10 g of feverfew, 10 g of oat bran, 10 g of Magnolia officinalis bark, and 10 g of Stephania tetrandra root were stirred and mixed, dried, crushed, and passed through a 40-mesh sieve to obtain a mixed powder;

[0063] S2: Add 600 g of ethanol aqueous solution to the mixed powder, adjust the pH value with glacial acetic acid, heat and reflux for 2 h, filter, collect the extract, and perform a second extraction on the residue;

[0064] S3: Add 400 g of ethanol aqueous solution to the residue after extraction, adjust the pH value with concentrated ammonia water, heat and reflux for 2 h, filter, and collect the extract;

[0065] S4: Combine the two extracts and concentrate to a paste;

[0066] S5: dissolving the concentrated paste with hot water, adjusting the pH to 7 with concentrated ammonia water, adsorbing with modified D101 macroporous adsorption resin, loading the modified D101 macroporous adsorption resin into a chromatography column, eluting with 6 column volumes of pure water, and then eluting with 5 column volumes of ethanol aqueous solution, collecting the ethanol aqueous eluate, concentrating, and drying to obtain a mixed extract of the plant composition;

[0067] S6: Take 0.5g of the mixed extract of the plant composition, add it to 45g of polyol, heat and stir until completely dissolved, add a total of 50g of water in 6 times, stirring while adding until the solution is clear and transparent, filter with a 0.22μm filter membrane to obtain a composition with soothing and repairing functions.

[0068] The mass concentration of the ethanol aqueous solution is 60%.

[0069] The pH value of S2 was adjusted to 4.5.

[0070] The pH value of S3 was adjusted to 8.5.

[0071] The adsorption time of S5 is 21h.

[0072] The polyol is propylene glycol.

[0073] The preparation method of the modified D101 macroporous adsorption resin comprises the following steps:

[0074] The D101 macroporous adsorption resin is sent into a radio frequency plasma generator for functional group modification; it is spread evenly on a porcelain boat and placed in the radio frequency plasma generator; under the condition of a power of 150W, ammonia, piceatannol and 2-pyrazinylethanethiol vapor are mixed in a volume ratio and then introduced into the plasma chamber; the gas flow rate is controlled within the range of 30mL / min; the D101 macroporous adsorption resin is treated with a plasma with a frequency of 13.56MHz for 18 minutes; after the treatment is completed, the modified D101 macroporous adsorption resin is taken out to obtain.

[0075] The ammonia, piceatannol and 2-pyrazinylethanethiol are mixed in a volume ratio of 1:0.4:0.01 and then introduced into the plasma chamber.

[0076] Example 3

[0077] A method for preparing a composition with soothing and repairing functions, the operating steps are:

[0078] S1: 15 g of horse chestnut fruit, 15 g of feverfew, 15 g of oat bran, 15 g of Magnolia officinalis bark, and 15 g of Stephania tetrandra root were stirred and mixed, dried, crushed, and passed through a 40-mesh sieve to obtain a mixed powder;

[0079] S2: Add 900 g of ethanol aqueous solution to the mixed powder, adjust the pH value with glacial acetic acid, heat and reflux for 2.5 h, filter, collect the extract, and perform a second extraction on the residue;

[0080] S3: Add 500 g of ethanol aqueous solution to the residue after extraction, adjust the pH value with concentrated ammonia water, heat and reflux for 2.5 h, filter and collect the extract;

[0081] S4: Combine the two extracts and concentrate to a paste;

[0082] S5: dissolving the concentrated paste with hot water, adjusting the pH to 8 with concentrated ammonia water, adsorbing with modified D101 macroporous adsorption resin, loading the modified D101 macroporous adsorption resin into a chromatography column, eluting with 9 column volumes of pure water, and then eluting with 7 column volumes of ethanol aqueous solution, collecting the ethanol aqueous eluate, concentrating, and drying to obtain a mixed extract of the plant composition;

[0083] S6: Take 0.8g of the mixed extract of the plant composition, add it to 55g of polyol, heat and stir until completely dissolved, add a total of 70g of water in 7 times, stirring while adding until the solution is clear and transparent, filter with a 0.22μm filter membrane to obtain a composition with soothing and repairing functions.

[0084] The mass concentration of the ethanol aqueous solution is 70%.

[0085] The pH value of S2 was adjusted to 5.5.

[0086] The pH value of S3 was adjusted to 9.5.

[0087] The adsorption time of S5 is 23h.

[0088] The polyol is pentanediol.

[0089] The preparation method of the modified D101 macroporous adsorption resin comprises the following steps:

[0090] The D101 macroporous adsorption resin is sent into a radio frequency plasma generator for functional group modification; it is spread evenly on a porcelain boat and placed in the radio frequency plasma generator; under the condition of a power of 250W, ammonia, piceatannol and 2-pyrazinylethanethiol vapor are mixed in a volume ratio and then introduced into the plasma chamber; the gas flow rate is controlled within the range of 40mL / min; the D101 macroporous adsorption resin is treated with a plasma with a frequency of 13.56MHz for 23 minutes; after the treatment is completed, the modified D101 macroporous adsorption resin is taken out to obtain.

[0091] The ammonia, piceatannol and 2-pyrazinylethanethiol are mixed in a volume ratio of 1:0.5:0.015 and then introduced into the plasma chamber.

[0092] Example 4

[0093] A method for preparing a composition with soothing and repairing functions, the operating steps are:

[0094] S1: 20 g of horse chestnut fruit, 20 g of feverfew, 20 g of oat bran, 20 g of Magnolia officinalis bark, and 20 g of Stephania tetrandra root were stirred, dried, crushed, and passed through a 40-mesh sieve to obtain a mixed powder;

[0095] S2: Add 1000 g of ethanol aqueous solution to the mixed powder, adjust the pH value with glacial acetic acid, heat and reflux for 3 h, filter, collect the extract, and perform a second extraction on the residue;

[0096] S3: Add 600 g of ethanol aqueous solution to the residue after extraction, adjust the pH value with concentrated ammonia water, heat and reflux for 3 h, filter and collect the extract;

[0097] S4: Combine the two extracts and concentrate to a paste;

[0098] S5: dissolving the concentrated paste with hot water, adjusting the pH to 8 with concentrated ammonia water, adsorbing with modified D101 macroporous adsorption resin, loading the modified D101 macroporous adsorption resin into a chromatography column, eluting with 10 column volumes of pure water, and then eluting with 8 column volumes of ethanol aqueous solution, collecting the ethanol aqueous eluate, concentrating, and drying to obtain a mixed extract of the plant composition;

[0099] S6: Take 1g of the mixed extract of the plant composition, add it to 60g of polyol, heat and stir until completely dissolved, add a total of 80g of water in 8 times, stirring while adding until the solution is clear and transparent, filter with a 0.22μm filter membrane to obtain a composition with soothing and repairing functions.

[0100] The mass concentration of the ethanol aqueous solution is 80%.

[0101] The pH value of S2 was adjusted to 6.5.

[0102] The pH value of S3 was adjusted to 10.5.

[0103] The adsorption time of S5 is 24h.

[0104] The polyol is hexanediol.

[0105] The preparation method of the modified D101 macroporous adsorption resin comprises the following steps:

[0106] The D101 macroporous adsorption resin is sent into a radio frequency plasma generator for functional group modification; it is spread evenly on a porcelain boat and placed in the radio frequency plasma generator; under the condition of a power of 300 W, ammonia, piceatannol and 2-pyrazinylethanethiol vapor are mixed in a volume ratio and then introduced into the plasma chamber; the gas flow rate is controlled within the range of 50 mL / min; the D101 macroporous adsorption resin is treated with a plasma with a frequency of 13.56 MHz for 25 minutes; after the treatment is completed, the modified D101 macroporous adsorption resin is taken out to obtain.

[0107] The ammonia, piceatannol and 2-pyrazinylethanethiol are mixed in a volume ratio of 1:0.6:0.02 and then introduced into the plasma chamber.

[0108] Comparative Example 1

[0109] The D101 macroporous adsorption resin was not modified, and the other steps were the same as in Example 1.

[0110] Comparative Example 2

[0111] The other steps were the same as in Example 1 except that piceatannol was not added.

[0112] Comparative Example 3

[0113] The other steps were the same as in Example 1 except that 2-pyrazinylethanethiol was not added.

[0114] The test results are shown in Table 1.

[0115] Table 1

[0116]

[0117] Through the data analysis of the above examples and comparative examples, the soothing and repairing composition prepared by the present invention has the effects of inhibiting ear swelling, reducing inflammation, relieving itching, etc., and can effectively repair the skin barrier.

[0118] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A method for preparing a composition with soothing and repairing functions, the operating steps are: S1: according to weight, 5-20 parts of horse chestnut fruit, 5-20 parts of feverfew chrysanthemum, 5-20 parts of oat bran, 5-20 parts of Magnolia officinalis bark, and 5-20 parts of Stephania tetrandra root are stirred and mixed, dried, crushed, and passed through a 40-mesh sieve to obtain a mixed powder; S2: Add 500-1000 parts of ethanol aqueous solution to the mixed powder, adjust the pH value with glacial acetic acid, heat and reflux for extraction for 1.5-3h, filter, collect the extract, and extract the residue for the second time; S3: Add 300-600 parts of ethanol aqueous solution to the residue after extraction, adjust the pH value with concentrated ammonia water, heat and reflux for extraction for 1.5-3h, filter and collect the extract; S4: Combine the two extracts and concentrate to a paste; S5: dissolving the concentrated paste with hot water, adjusting the pH to 7-8 with concentrated ammonia water, adsorbing with modified D101 macroporous adsorption resin, loading the modified D101 macroporous adsorption resin into a chromatography column, eluting with 5-10 column volumes of pure water, and then eluting with 3-8 column volumes of ethanol aqueous solution, collecting the ethanol aqueous eluate, concentrating, and drying to obtain a mixed extract of the plant composition; S6: Take 0.1-1 parts of the mixed extract of the plant composition, add it to 40-60 parts of the polyol, heat and stir until completely dissolved, add a total of 40-80 parts of water in 5-8 times, stir while adding, until the solution is clear and transparent, filter with a 0.22 μm filter membrane, and obtain a composition with soothing and repairing functions; The modified D101 macroporous adsorption resin is prepared by reacting the D101 macroporous adsorption resin with ammonia, piceatannol and 2-pyrazinylethanethiol steam in a radio frequency plasma generator.

2. The method for preparing a composition with soothing and repairing functions according to claim 1, characterized in that: The mass concentration of the ethanol aqueous solution is 50-80%.

3. The method for preparing a composition with soothing and repairing functions according to claim 1, characterized in that: The pH value of S2 is adjusted to 3.5-6.

5.

4. The method for preparing a composition with soothing and repairing functions according to claim 1, characterized in that: The pH value of S3 is adjusted to 7.5-10.

5.

5. The method for preparing a composition with soothing and repairing functions according to claim 1, characterized in that: The adsorption time of S5 is 20-24h.

6. The method for preparing a composition with soothing and repairing functions according to claim 1, characterized in that: The polyol is one of butanediol, propylene glycol, glycerol, pentanediol and hexanediol.

7. The method for preparing a composition with soothing and repairing functions according to claim 1, characterized in that: The preparation method of the modified D101 macroporous adsorption resin comprises the following steps: The D101 macroporous adsorption resin is sent into a radio frequency plasma generator for functional group modification; it is spread evenly on a porcelain boat and placed in the radio frequency plasma generator; under the condition of a power of 100W-300W, ammonia, piceatannol and 2-pyrazinylethanethiol vapor are mixed in a volume ratio and then introduced into a plasma chamber; the gas flow rate is controlled within the range of 20-50mL / min; the D101 macroporous adsorption resin is treated with a plasma with a frequency of 13.56MHz for 15-25 minutes; after the treatment is completed, the modified D101 macroporous adsorption resin is taken out to obtain.

8. The method for preparing a composition with soothing and repairing functions according to claim 7, characterized in that: The ammonia, piceatannol and 2-pyrazinylethanethiol are mixed in a volume ratio of 1: (0.2-0.6): (0.001-0.02) and then introduced into the plasma chamber.

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