Sanitary insecticidal composition and application thereof

Abstract

The invention relates to an insecticidal composition, in particular to a sanitary insecticidal composition and application thereof. The composition comprises a component A and a component B, wherein the component A is a compound as shown in a formula I; the component B is bendiocarb, carbosulfan, propoxur or carbaryl; the compounded insecticide composition has a synergistic effect in a certain proportion, has improved knockdown and death effects compared with a single agent, and is suitable for preventing and treating sanitary pests such as mosquitoes, flies, fleas, ants, cockroaches, mites, wasps and bed bugs. # imgabs0 #

Description

Technical Field

[0001] The present invention relates to an insecticide composition, in particular to a sanitary insecticide composition and its application. Background Art

[0002] The configuration, preparation method and application of the methoxyacrylate compound of formula I in controlling sanitary pests have been disclosed in some patents, but the application research of its compounding aspect has not been involved. Due to the long-term use of pesticides, the resistance of sanitary pests to organophosphorus, carbamate and pyrethroid insecticides is getting higher and higher. In practical applications, highly active compounds are needed to improve the control effect and reduce the amount of pesticides used. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide a sanitary insecticide composition and its application in view of the deficiencies in the prior art.

[0004] In order to achieve the above object, the present invention adopts the following technical solution:

[0005] A sanitary insecticide composition, the composition comprises component A and component B, wherein component A is a compound represented by formula I; component B is benfenac, carbosulfan, propoxur or carbaryl;

[0006] Formula I:

[0007]

[0008] Preferably, the weight ratio of component A to component B in the composition is 10:1 to 1:20.

[0009] The weight ratio of component A to component B in the composition is 2:1 to 1:20.

[0010] An application of the sanitary insecticide composition, wherein the sanitary insecticide composition is used to control sanitary pests in places where sanitary pests are present.

[0011] The sanitary pests are one or more of mosquitoes, flies, fleas, ants, cockroaches, mites, wasps and bedbugs; and the places where the sanitary pests appear are hotels, airplanes, schools, factories, family residences or livestock habitats.

[0012] The sanitary pests are preferably Culex pipiens pallens, Culex pipiens quinquefasciatus, Culex tritaeniorhynchus, Aedes albopictus, Aedes aegypti, Anopheles sinensis, Aedes harassingus, Chironomids, housefly, city fly, Chrysopa longituba, Lucilia sericata, Lucilia cuprina, Lucilia luminifera, summer toilet fly, Yuan toilet fly, German cockroach, American cockroach, bed bug, flea, Ixodes persulcatus, Ixodes sinensis, Ixodes prairies, Boophilus microplus, Gamas, scabies, ants and wasps.

[0013] A sanitary insecticide preparation comprises active ingredients and adjuvants. The active ingredient in the preparation is the composition, and the composition accounts for 2% to 80% of the total weight of the insecticide group.

[0014] The preparation dosage form is emulsifiable concentrate, water emulsion, microemulsion, wettable powder, suspension, water dispersible granule, dry suspension or microcapsule suspension.

[0015] The auxiliary agent in the preparation is any one or more of a dispersant, a wetting agent, a disintegrant, a filler, an antifreeze agent, a thickener, a preservative, a defoamer, a solvent, an emulsifier, an encapsulating material, an organic amine and deionized water.

[0016] The sanitary insecticide preparation, when in the form of emulsifiable concentrate, comprises the following raw materials in weight percentage: 1-20% of component A, 1-20% of component B, 5-30% of emulsifier, and the solvent is supplemented to 100%.

[0017] The sanitary insecticide preparation, when in the form of an aqueous emulsion, comprises the following raw materials in weight percentage: 1-15% of component A, 1-15% of component B, 5-20% of solvent, 6-20% of emulsifier, 3-8% of antifreeze, 0.1-1% of defoamer, and deionized water is added to make up to 100%.

[0018] The sanitary insecticide preparation, when in the form of a microemulsion, comprises the following raw materials in weight percentage: 1-15% of component A, 1-15% of component B, 3-30% of solvent, 10-35% of emulsifier, and deionized water is added to 100%.

[0019] The sanitary insecticide preparation, when in the form of wettable powder, comprises the following raw materials in weight percentage: 1-20% of component A, 1-50% of component B, 2-6% of wetting agent, 7-18% of dispersant, and the filler is supplemented to 100%.

[0020] The sanitary insecticide preparation, when in the form of a suspension, comprises the following raw materials in weight percentage: 1-20% of component A, 1-20% of component B, 1-8% of a wetting agent, 1-8% of a dispersant, 3-7% of an antifreeze agent, 0.3-2% of a preservative, 0.1-1% of a defoaming agent, 0.5-3% of a thickener, and deionized water is added to make up to 100%.

[0021] The sanitary insecticide preparation, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 1-20% of component A, 1-40% of component B, 2-12% of wetting agent, 5-18% of dispersant, 2-8% of disintegrant, and the filler is supplemented to 100%.

[0022] The sanitary insecticide preparation, when in the form of a dry suspension, comprises the following raw materials in weight percentage: 1-20% of component A, 1-40% of component B, 1-8% of a wetting agent, 1-8% of a dispersant, and fillers supplemented to 100%.

[0023] The sanitary insecticide preparation, when in the form of a microcapsule suspension, comprises the following raw materials in percentages: 1-20% of component A, 1-20% of component B, 1-5% of a wetting agent, 1-10% of a capsule-forming material, 1-8% of a dispersant, 2-6% of an antifreeze agent, 0.3-1% of a preservative, 0.1-1% of a defoaming agent, 0.5-2% of a thickener, 0.1-5% of an organic amine, and deionized water is added to make up to 100%.

[0024] The dispersant is selected from any one of polycarboxylates, lignin sulfonates, alkylphenol polyoxyethylene ether formaldehyde condensates, naphthalenesulfonic acid formaldehyde condensates sodium salts, nonionic hydroxy polyethylene oxide block copolymers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene esters, and glycerol fatty acid ester polyoxyethylene ethers, or a mixture of two or more of the above in any proportion.

[0025] The wetting agent is selected from: any one of naphthalene sulfonate, sodium dodecyl sulfate, pull-open powder BX, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, dodecylbenzene sulfonic acid, or a mixture of two or more in any proportion.

[0026] The disintegrant is selected from any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate, and sodium sulfate, or a mixture of two or more of the above in any proportion.

[0027] The filler is selected from: any one of kaolin, white carbon black, corn starch, attapulgite, calcium carbonate, light calcium, diatomaceous earth, or a mixture of two or more of them in any proportion.

[0028] The antifreeze agent is any one of ethylene glycol, propylene glycol, glycerol, glycerin and urea, or a mixture of two or more of them in any proportion.

[0029] The thickener is any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate and organic bentonite, or a mixture of two or more of the above in any proportion.

[0030] The preservative is any one of sodium benzoate, benzoic acid, potassium sorbate and kason, or a mixture of two or more of them in any proportion.

[0031] The defoaming agent is any one of silicone compounds, silicone oil, C8-10 fatty alcohol compounds, and C10-20 saturated fatty acid compounds, or a mixture of two or more of the above in any proportion.

[0032] The solvent is selected from: any one of 100# solvent oil, 150# solvent oil, 200# solvent oil, dimethylformamide, dimethylacetamide, xylene, N-methylpyrrolidone, turpentine, soybean oil, methyl oleate, corn oil, rapeseed oil, castor oil, and C8-16 alkane solvents, or a mixture of two or more of them in any proportion.

[0033] The C8-16 alkane solvent is selected from: D60 (ExxonMobil Petrochemical Company), D80 (ExxonMobil Petrochemical Company), D100 (ExxonMobil Petrochemical Company), D110 (ExxonMobil Petrochemical Company), Isopar-E (ExxonMobil Petrochemical Company), Isopar-G (ExxonMobil Petrochemical Company), Isopar-H (ExxonMobil Petrochemical Company), Isopar-L (ExxonMobil Petrochemical Company), Isopar-M (ExxonMobil Petrochemical Company), any one of quinane, undecane, dodecane, tridecane, tetradecane, pentadecane, hexadecane, heptadecane, and octadecane, or a mixture of two or more in any proportion.

[0034] The emulsifier is selected from: any one of calcium dodecylbenzene sulfonate, OP series phosphate, alkylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, Span series, Tween series, fatty alcohol polyoxyethylene ether, styrylphenol polyoxyethylene ether, styrylphenol polyoxyethylene ether phosphate, alkylaryl polyoxyethylene ether polyoxypropylene ether, or a mixture of two or more in any proportion.

[0035] The capsule forming material is selected from: any one of diphenylmethane diisocyanate and tolyl diisocyanate, or a mixture of the two in any proportion.

[0036] The organic amine is selected from any one of ethylenediamine, propylenediamine, butylenediamine, octanediamine, diethylenetriamine, and 1,6-hexanediamine, or a mixture of any two of them in any proportion.

[0037] When the sanitary insecticide is used to control sanitary pests, a residual spraying method is adopted: the sanitary insecticide is diluted with water (50-1000 times) and then sprayed on the surfaces of walls, doors and windows, ceilings, plants and homes in places where sanitary pests are present. Applicable dosage forms are suspension concentrates, wettable powders, water-dispersible granules, microcapsule suspension concentrates and dry suspension concentrates.

[0038] When the sanitary insecticide is used to control sanitary pests, it is sprayed in space. After the sanitary insecticide is diluted with water (5-200 times), it is evenly sprayed into the space where the sanitary pests are present by means of constant volume spray, low volume spray or ultra-low volume spray. Applicable dosage forms are emulsifiable concentrate, water emulsion and microemulsion.

[0039] The advantages of the present invention are:

[0040] The insecticidal composition of the present invention uses the methoxyacrylate compound shown in formula I as one of the active ingredients, and is compounded with a carbamate insecticide with strong knockdown and lethal properties, which can significantly improve the knockdown rate and lethality, quickly reduce the density of mosquitoes and flies, delay the development of resistance, and reduce the frequency of application. DETAILED DESCRIPTION

[0041] The specific implementation methods of the technical solution of the present invention are described in detail below, but the present invention is not limited to the following description. The present invention is explained below in conjunction with specific embodiments.

[0042] The insecticide composition of the present invention has a synergistic effect at a certain ratio, has higher activity than individual components, can significantly increase the knockdown rate and mortality rate, quickly reduce the density of mosquitoes and flies, delay the generation of resistance, and reduce the frequency of application.

[0043] In the following embodiments

[0044] The laboratory preparation method of wettable powder is as follows: add component A, component B, wetting agent, dispersant and filler into a food processor and mix them evenly, then put them into a jet mill for crushing.

[0045] The laboratory preparation method of the suspension concentrate is as follows: weigh the wetting agent, dispersant, antifreeze, preservative, defoamer and water according to the proportion, add them into a beaker and mix them evenly, then add component A and component B into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, add thickener and continue grinding for 0.5 hours, and make the particle size D 95 The product can be obtained by controlling the particle size below 5 microns and filtering to remove the zirconium oxide beads.

[0046] The laboratory preparation method of water-dispersible granules is as follows: add component A, component B, wetting agent, dispersant, disintegrant and filler into a food processor and mix them evenly, then put them into a jet mill for grinding, mix them again with a food processor, add an appropriate amount of water, and extrude and granulate them with a granulator.

[0047] The laboratory preparation method of the dry suspension is as follows: weigh the wetting agent, dispersant, filler and water according to the proportion, add them into a beaker and mix them evenly, then add component A and component B into the beaker, and then transfer it to a sand mill, add zirconium oxide beads into the sand mill, grind for 2-3 hours, and make the particle size D 95The particle size is controlled below 5 microns, the zirconium oxide beads are removed by filtration, and the obtained material is dried by a spray dryer to obtain the product.

[0048] The preparation method of emulsifiable concentrate is as follows: dissolve component A and component B in a solvent, add an emulsifier, mix and dissolve under stirring to form a transparent liquid.

[0049] The preparation method of the water emulsion is as follows: component A, component B, solvent and emulsifier are dissolved into oil phase, deionized water, antifreeze agent and defoaming agent form water phase, and the water phase is added to the oil phase or the oil phase is added to the water phase under high-speed shearing to obtain the water emulsion.

[0050] The preparation method of the microemulsion is as follows: after component A, component B, solvent and emulsifier are uniformly dissolved, deionized water is added to form a transparent liquid to obtain the microemulsion.

[0051] Preparation method of microcapsule suspension: Component A, capsule material and solvent are heated and dissolved to form an oil phase, and then added to the water phase under shearing conditions, sheared for 5 minutes, and organic amine was slowly added dropwise, and then kept warm at a certain temperature and solidified. After the reaction is completed, the pH is adjusted, and finally deionized water is added to make up to 100g to obtain a microcapsule suspension.

[0052] Formulation Example 1: 1% Component A·Propoxur EC

[0053] Component A 0.5g, propoxur 0.5g, calcium dodecylbenzene sulfonate 5g, castor oil polyoxyethylene ether 9g, dimethylformamide 5g, 150# solvent oil is added to make up to 100g, and emulsifiable concentrate is prepared according to the above method.

[0054] Formulation Example 2: 12% Component A·Propoxur EC

[0055] Component A 2g, propoxur 10g, calcium dodecylbenzene sulfonate 7g, alkylphenol polyoxyethylene ether 10g, N-methylpyrrolidone 5g, 150# solvent oil is added to make up to 100g, and emulsifiable concentrate is prepared according to the above method.

[0056] Formulation Example 3: 6% Component A: Benthiocarb emulsifiable concentrate

[0057] Component A 1g, benomyl 5g, Span 80 6g, alkylphenol polyoxyethylene ether 8g, dimethylformamide 5g, 150# solvent oil is added to make up to 100g, and emulsifiable concentrate is prepared according to the above method.

[0058] Formulation Example 4: 16% Component A: Benthiocarb emulsifiable concentrate

[0059] Component A1g, benomyl 15g, calcium dodecylbenzene sulfonate 15g, styrylphenol polyoxyethylene ether 8g, N-methylpyrrolidone 5g, and xylene are added to make up to 100g, and an emulsifiable concentrate is prepared according to the above method.

[0060] Formulation Example 5: 22% Component A·Carbosulfan emulsifiable concentrate

[0061] Component A 2g, carbosulfan 20g, calcium dodecylbenzene sulfonate 13g, castor oil polyoxyethylene ether 7g, N-methyl pyrrolidone 5g, 150# solvent oil is supplemented to 100g, and emulsifiable concentrate is prepared according to the above method.

[0062] Formulation Example 6: 10% Component A·Propoxur aqueous emulsion

[0063] Component A 2g, propoxur 8g, calcium dodecylbenzene sulfonate 2g, castor oil polyoxyethylene ether 8g, styrylphenol polyoxyethylene ether 4g, n-butanol 2g, 100# solvent oil 15g, ethylene glycol 5g, silicone compound 0.5g, deionized water is added to make up to 100g, and an aqueous emulsion is prepared according to the above method.

[0064] Formulation Example 7: 9% Component A·Carbaryl Microemulsion

[0065] Component A 6g, carbaryl 3g, castor oil polyoxyethylene ether 20g, styrylphenol polyoxyethylene ether phosphate 10g, 150# solvent oil 30g, deionized water to make up to 100g, and a microemulsion was prepared according to the above method.

[0066] Formulation Example 8: 15% Component A·Propoxur Microemulsion

[0067] Component A 3g, propoxur 12g, castor oil polyoxyethylene ether 30g, 150# solvent oil 30g, deionized water to make up to 100g, and a microemulsion was prepared according to the above method.

[0068] Formulation Example 9: 11% Component A: Effemoxadone Emulsion

[0069] Component A 3g, benomyl 8g, calcium dodecylbenzene sulfonate 2g, styrylphenol polyoxyethylene ether 10g, n-butanol 2g, 150# solvent oil 15g, ethylene glycol 5g, silicone compound 0.5g, deionized water is added to make up to 100g, and an aqueous emulsion is prepared according to the above method.

[0070] Formulation Example 10: 14% Component A·Carbosulfan aqueous emulsion

[0071] Component A 4g, carbosulfan 10g, calcium dodecylbenzene sulfonate 2g, castor oil polyoxyethylene ether 9g, n-butanol 2g, 150# solvent oil 15g, ethylene glycol 5g, silicone compound 0.5g, deionized water is added to make up to 100g, and an aqueous emulsion is prepared according to the above method.

[0072] Formulation Example 11: 20% Component A·Propoxur Suspension

[0073] Component A 10g, propoxur 10g, sodium lauryl sulfate 4g, lignin sulfonate 6g, propylene glycol 2g, ethylene glycol 3g, potassium sorbate 0.5g, magnesium aluminum silicate 1g, xanthan gum 0.3g, silicone oil 0.2g, deionized water is added to make up to 100g. The suspension is prepared according to the above method.

[0074] Formulation Example 12: 15% Component A: Mefenacet suspension

[0075] Component A 7g, benzylpyridinium 8g, alkyl sulfate 6g, alkyl sulfonate 2g, polycarboxylate 3g, lignin sulfonate 4g, propylene glycol 1g, urea 3g, potassium sorbate 0.5g, magnesium aluminum silicate 0.5g, xanthan gum 0.4g, silicone oil 0.2g, deionized water is added to make up to 100g. A suspension is prepared according to the above method.

[0076] Formulation Example 13: 40% Component A·Propoxur Suspension

[0077] Component A 20g, propoxur 20g, alkylbenzene polyoxyethylene ether phosphate 2g, alkyl sulfonate 2g, lignin sulfonate 4g, glycerol 5g, sodium benzoate 0.5g, kason 0.3g, magnesium aluminum silicate 0.5g, xanthan gum 0.2g, silicone oil 0.2g, deionized water is added to 100g. The suspension is prepared according to the above method.

[0078] Formulation Example 14: 60% Component A·Propoxur Water Dispersible Granules

[0079] Component A 20g, propoxur 40g, alkyl sulfate 2g, lignin sulfonate 5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, sodium sulfate 1g, ammonium sulfate 3g, corn starch is added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0080] Formulation Example 15: 50% Component A: Mefenacet water dispersible granules

[0081] Component A 10g, benfenac 40g, lakai powder BX 8g, sodium lauryl sulfate 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 10g, ammonium sulfate 5g, kaolin is added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0082] Formulation Example 16: 60% Component A·Carbosulfan Water Dispersible Granules

[0083] Component A 20g, carbosulfan 40g, sodium dodecyl sulfate 6g, lignin sulfonate 8g, naphthalenesulfonic acid formaldehyde condensate sodium salt 12g, sodium sulfate 3g, corn starch is added to make up to 100g. Water dispersible granules are prepared according to the above method.

[0084] Formulation Example 17: 50% Component A: Mefenacet wettable powder

[0085] Component A 10g, benomyl 40g, alkyl sulfate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, lignin sulfonate 4g, white carbon black 3g, kaolin is added to make up to 100g. Wettable powder is prepared according to the above method.

[0086] Formulation Example 18: 30% Component A·Carbaryl Wettable Powder

[0087] Component A 10g, carbaryl 20g, alkyl sulfate 5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 10g, fatty amine polyoxyethylene ether 2g, white carbon black 3g, kaolin is added to make up to 100g. Wettable powder is prepared according to the above method.

[0088] Formulation Example 19: 60% Component A·Propoxur dry suspension

[0089] Component A 20g, propoxur 40g, alkyl sulfate 5g, polycarboxylate 5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, corn starch is added to make up to 100g. A dry suspension is prepared according to the above method.

[0090] Formulation Example 20: 10% Component A·Carbaryl Microcapsule Suspension

[0091] 4g of component A, 6g of carbaryl, 2g of sodium dodecyl sulfate, 5g of nonionic hydroxypolyethylene oxide block copolymer, 2g of phenethylphenol polyoxyethylene ether phosphate and 1g of diphenylmethane diisocyanate are heated and dissolved, and then added to 60g of an aqueous solution containing 5% propylene glycol under shearing conditions, sheared for 5 minutes, 0.25g of diethylenetriamine was slowly added dropwise, and then kept warm at 50°C for 5h. After the reaction is completed, the pH value is adjusted to 4-6 with acetic acid, and then 1g of xanthan gum, 0.5g of potassium sorbate and 0.5g of silicone oil are added, and finally the amount is supplemented to 100g with deionized water. After stirring evenly, a microcapsule suspension can be obtained.

[0092] Comparative Example 1: 10% component A emulsifiable concentrate

[0093] Component A10g, calcium dodecylbenzene sulfonate 6g, castor oil polyoxyethylene ether 8g, 150# solvent oil to 100g, according to the above method to prepare emulsifiable concentrate

[0094] Comparative Example 2: 10% Propoxur EC

[0095] Propoxur 10g, calcium dodecylbenzene sulfonate 6g, castor oil polyoxyethylene ether 8g, 150# solvent oil to 100g, according to the above method to prepare emulsifiable concentrate

[0096] Comparative Example 3: 20% Component A Wettable Powder

[0097] Component A 20g, alkyl sulfate 5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 10g, fatty amine polyoxyethylene ether 2g, white carbon black 3g, kaolin to make up to 100g. Wettable powder was prepared according to the above method.

[0098] Comparative Example 4: 20% Propoxur Wettable Powder

[0099] Propoxur 20g, alkyl sulfate 5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 10g, fatty amine polyoxyethylene ether 2g, white carbon black 3g, kaolin is added to make up to 100g. Wettable powder is prepared according to the above method.

[0100] Control agent 1: 10% highly effective cyhalothrin wettable powder (commercially available)

[0101] Control agent 2: 5% tetrafluthrin / permethrin emulsion in water (commercially available)

[0102] Verification test 1: Co-toxicity coefficient test

[0103] (1) Test subjects: Culex pipiens, Musca domestica (laboratory reared)

[0104] (2) Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of the combined effect of mixtures"

[0105] (3) Data statistics: The drug to be tested was first dissolved in dichloromethane, and then serially diluted with an aqueous solution containing 0.1% Triton-X100 at a ratio of 1:9. 1 mL of each diluted concentration was added to a 150 mL serum bottle, and the serum bottle was rotated continuously to evenly distribute the drug solution on the inner wall of the bottle. The bottle was placed in a fume hood overnight to allow the organic solvent to evaporate completely, and test insects were placed to determine the concentration range of the drug that caused 100% death and 100% survival. Within this range, a suitable concentration was selected and serially diluted with an aqueous solution containing 0.1% Triton-X100. 1 mL of each diluted concentration was added to a 150 mL serum bottle, and the serum bottle was rotated continuously to evenly distribute the drug solution on the inner wall of the bottle. The bottle was placed in a fume hood overnight to allow the organic solvent to evaporate completely. Vaseline was then applied to the bottleneck of the serum bottle, and 20 test insects were placed in each bottle. The experiment was repeated 5 times. The corresponding solvent treatment was used as the control group. After 1 hour, all test insects were transferred to clean containers for standard feeding. After 24 hours, the number of deaths was checked and counted. The statistical analysis software SPSS was used for analysis to calculate the LC of each agent. 50 and its 95% confidence limit. The results are shown in the following table:

[0106] Table 1 Co-toxicity coefficient of component A and propoxur to housefly

[0107]

[0108] It can be seen from Table 1 that when the combination ratio of component A: propoxur is between 10:1 and 1:20, the co-toxicity coefficient to houseflies is greater than 120, showing a synergistic effect, especially when the combination ratio is between 2:1 and 1:20, the co-toxicity coefficient to houseflies is greater than 150, with an obvious synergistic effect.

[0109] Table 2 Co-toxicity coefficient of component A and propoxur to Culex pipiens pallens

[0110]

[0111] It can be seen from Table 2 that when the combination ratio of component A: propoxur is between 10:1 and 1:20, the co-toxicity coefficient to Culex pipiens is greater than 120, showing a synergistic effect, especially when the combination ratio is between 2:1 and 1:20, the co-toxicity coefficient to Culex pipiens is greater than 150, with an obvious synergistic effect.

[0112] In addition, when the compound ratio of component A and other components B is 2:1 to 1:20, there is also a similar synergistic effect on mosquitoes and flies.

[0113] Verification test 2: Efficacy test of mosquito and fly control spray

[0114] (1) Test subjects: Culex pipiens and housefly (laboratory reared)

[0115] (2) Test method: Refer to GB / T13917.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, spray test.

[0116] (3) Test agents: Preparation Examples 2, 3, 4, 5, 6, 7, 8, 9, and 10 were diluted with water to 1000 ppm, and Comparative Example 1, Comparative Example 2, and Control Agent 2 were diluted with water to 1000 ppm.

[0117] (4) Statistics:

[0118] Table 3 Results of efficacy tests of several treatments against Culex pipiens and houseflies

[0119]

[0120] As shown in Table 3, the pharmaceutical efficacy of the preparation examples of the present invention is superior to that of existing products on the market, and the combination of composition A and carbamate agents has a synergistic effect.

[0121] Verification test 3: Efficacy test for preventing and controlling mosquitoes and flies

[0122] (1) Test subjects: Culex pipiens and Musca domestica

[0123] (2) Test method: Refer to GB / T13917.1-2009 Indoor efficacy test and evaluation of public health insecticides for pesticide registration, residual spraying test.

[0124] (3) Test agents: Preparation Examples 11, 12, 13, 14, 15, 16, 17, 18, 19, and 20 were diluted with water to 800 ppm, and Comparative Example 3, Comparative Example 4, and Control Agent 1 were diluted with water to 800 ppm.

[0125] (4) Statistics:

[0126] Table 4 Results of efficacy tests of several treatments against Culex pipiens and houseflies

[0127]

[0128]

[0129] As shown in Table 3, the pharmaceutical efficacy of the preparation examples of the present invention is superior to that of existing products on the market, and the combination of composition A and carbamate agents has a synergistic effect.

[0130] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A sanitary insecticidal composition, characterized in that: The composition comprises component A and component B, wherein component A is a compound represented by formula I; component B is benfenac, carbosulfan, propoxur or carbaryl; Formula I:

2. The sanitary insecticidal composition according to claim 1, characterized in that The weight ratio of component A to component B in the composition is 10:1 to 1:

20.

3. The sanitary insecticidal composition according to claim 1, characterized in that The weight ratio of component A to component B in the composition is 2:1 to 1:

20.

4. An application of the sanitary insecticide composition according to claim 1, characterized in that: The sanitary insecticide composition is used to prevent and control sanitary pests in places where sanitary pests appear.

5. The use of the sanitary insecticide composition according to claim 4, characterized in that: The sanitary pests are one or more of mosquitoes, flies, fleas, ants, cockroaches, mites, wasps and bedbugs; and the places where the sanitary pests appear are hotels, airplanes, schools, factories, family residences or livestock habitats.

6. A sanitary insecticide preparation, active ingredients and adjuvants, characterized in that: The active ingredient in the preparation is the composition according to claim 1, and the composition accounts for 2% to 80% of the total weight of the insecticide group.

7. The sanitary insecticide preparation according to claim 6, characterized in that: The preparation dosage form is emulsifiable concentrate, aqueous emulsion, microemulsion, wettable powder, suspension, water-dispersible granules, dry suspension or microcapsule suspension.

8. The sanitary insecticide preparation according to claim 6 or 7, characterized in that: The auxiliary agent in the preparation is any one or more of a dispersant, a wetting agent, a disintegrant, a filler, an antifreeze agent, a thickener, a preservative, a defoamer, a solvent, an emulsifier, an encapsulating material, an organic amine and deionized water.

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