Cordycepin tablet as well as preparation method and application thereof

Abstract

The invention provides a cordycepin tablet as well as a preparation method and application thereof. The cordycepin tablet is prepared from the following raw materials: D-mannitol, a cordycepin extract, maltodextrin, a compound nutrition enhancer and magnesium stearate. The cordycepin tablet disclosed by the invention can be used for remarkably improving the storage capacity of hepatic glycogen, reducing amino acid catabolites and accelerating the elimination and metabolism speed of lactic acid in the exercise recovery period, and a specific vitamin ratio in the compound nutrition enhancer is matched and synergistic with cordycepin, so that the effects of enhancing the immunity of the organism and relieving fatigue can be achieved; therefore, the problems of fatigue and oxygen deficit after exercise are improved.

Description

Technical Field

[0001] The present invention relates to the technical field of nutritional foods, and in particular to a cordycepin tablet. The present invention also relates to a preparation method of the cordycepin tablet. The present invention also relates to an application of the cordycepin tablet. Background Art

[0002] As people's health awareness increases, the number of people doing sports and fitness continues to grow, especially the number of people doing high-load sports such as marathons, long-distance cycling, long-distance swimming, and skiing has increased significantly. In order to improve the effect of exercise and reduce sports injuries, nutritional guarantee is very important. Among them, sports nutrition food is the inevitable choice for such people who do exercise and fitness. There are many kinds of sports nutrition food, mainly including energy supplement, energy control, protein supplement, speed and strength, endurance, and post-exercise recovery.

[0003] There are many kinds of anti-fatigue products on the market, but anti-fatigue products with cordycepin as the main ingredient are relatively rare. In order to meet the physiological metabolic state, exercise capacity and special needs for certain nutrients of people who participate in middle- and long-distance running, jogging, brisk walking, cycling, swimming, rowing, aerobics, dancing, outdoor sports, etc. (referring to people who participate in physical exercise 3 times or more per week, each time lasting 30 minutes or more, and each exercise intensity is medium or above), it is urgent to develop a sports nutrition food with cordycepin as the characteristic ingredient. Summary of the invention

[0004] In view of this, the present invention aims to provide a cordycepin tablet, which can enhance the body's immunity, relieve fatigue, and improve the problems of post-exercise fatigue and hypoxia.

[0005] To achieve the above object, the technical solution of the present invention is achieved as follows:

[0006] A cordycepin tablet, the raw materials of which include D-mannitol, cordycepin extract, maltodextrin, a compound nutrient enhancer and magnesium stearate.

[0007] Furthermore, the weight proportions of the raw materials are: 30-50 parts of D-mannitol, 10-35 parts of cordycepin extract, 8-28 parts of maltodextrin, 7-14 parts of compound nutritional enhancer, and 1-2 parts of magnesium stearate.

[0008] Compared with the prior art, the present invention has the following advantages:

[0009] The cordycepin tablets of the present invention, as a sports nutrition food, can significantly increase the liver glycogen storage capacity, reduce amino acid decomposition metabolites, and accelerate the clearance and metabolism rate of lactic acid during the recovery period of exercise by mainly using 30-50 parts by weight of D-mannitol, 10-35 parts of cordycepin extract, 8-28 parts of maltodextrin, and 7-14 parts of a compound nutrition enhancer.

[0010] In addition, in the product formula, cordycepin extract, also known as Cordyceps militaris extract and cordycepin purified material, is a substance purified from cordyceps and Cordyceps militaris rich in cordycepin using modern processing technology. The purpose is to extract raw materials with high purity and content of cordycepin for making other products containing cordycepin ingredients. As the main active substance of Cordyceps militaris, cordycepin has the functions of regulating the body's immune function, improving the body's comprehensive disease resistance, anti-bacterial and anti-inflammatory, and inhibiting the proliferation of cancer cells. In addition, cordycepin can also help improve physical strength and endurance, and enhance the body's ability to resist fatigue.

[0011] Vitamin B1, vitamin B2 and vitamin B6 contained in the compound nutritional enhancer all have the effects of resisting fatigue and improving the body's endurance. They work synergistically with cordycepin, which has multiple functions, to enhance the body's immunity and relieve fatigue, thereby improving the problems of fatigue and hypoxia after exercise.

[0012] In addition, maltodextrin is used as an auxiliary material in compound nutritional enhancers to fill the body. Thiamine nitrate can promote the aerobic metabolism of glycogen, improve exercise endurance and exercise capacity, and accelerate the elimination of lactic acid in the body, reduce the soreness after exercise, and promote fatigue recovery. Riboflavin participates in the formation of various respiratory enzymes in the body, indirectly eliminating superoxide free radicals, thereby promoting aerobic energy supply in the body, delaying fatigue, and improving exercise endurance and exercise level. Pyridoxine hydrochloride participates in the metabolism of amino acids and the synthesis of heme cofactors, promotes the conversion of cholesterol, and can effectively prevent the occurrence of atherosclerosis and anemia. It can also delay sports fatigue and improve athletes' athletic ability by promoting the production of hemoglobin and gluconeogenesis, reducing lactic acid production and other biochemical pathways.

[0013] In addition, the cordycepin tablets of the present invention use a compounded nutritional enhancer and a cordycepin extract as main raw materials, and use D-mannitol, maltodextrin, and magnesium stearate as auxiliary materials. D-mannitol mainly acts as an excipient. Maltodextrin provides carbohydrates, which helps to maintain blood sugar stability. It mainly acts as a filler, a binder, a fluidity regulator, a water absorption regulator, a thermal stability enhancer, and the like. Magnesium stearate, as a processing aid, belongs to a hydrophobic lubricant and can be effectively mixed with particles. The tablets to which magnesium stearate is added can make the tablets look smoother and more beautiful after tabletting.

[0014] Another object of the present invention is to provide a method for preparing a cordycepin tablet, the method being used to prepare the cordycepin tablet according to claim 1 or 2, and the method comprising:

[0015] Weigh D-mannitol, cordycepin extract, compound nutrient enhancer, and maltodextrin according to weight proportions, and mix the weighed raw materials to obtain a premix;

[0016] Adding a binder to the premix, stirring evenly to obtain a granulated material, and preparing the granulated material into wet granules;

[0017] Drying the wet granules to obtain dry premix granules;

[0018] Mixing the premix particles with magnesium stearate to obtain a total mixed powder;

[0019] The total mixed powder is tableted according to a preset weight to prepare cordycepin tablets.

[0020] Furthermore, the particle size of the D-mannitol is not greater than 40 meshes.

[0021] Furthermore, the binder is 85% ethanol; and / or the weight ratio of the binder to the granulating material is between 32% and 40%.

[0022] Further, the moisture content of the dried premix particles is not greater than 7.5%, and / or the preset weight is 0.49 g / piece, and the weight difference limit is required to be ±5%.

[0023] Furthermore, before mixing the premix with magnesium stearate, the preparation method further comprises: sieving and granulating the premix particles.

[0024] Furthermore, after the total mixed powder is compressed into tablets according to a preset weight to obtain cordycepin tablets, the preparation method further comprises: coating the cordycepin tablets.

[0025] Compared with the prior art, the present invention has the following advantages:

[0026] In the preparation method of the cordycepin tablets of the present invention, 8 to 28 parts of maltodextrin and 7 to 14 parts of a compound nutritional enhancer are added during granulation, wherein the compound nutritional enhancer contains maltodextrin and B vitamins in a specific ratio, which can significantly enhance the effects of the cordycepin tablets in relieving physical fatigue and resisting hypoxia.

[0027] In addition, the present invention also proposes an application of the cordycepin tablets described above in the preparation of sports nutrition food for relieving physical fatigue.

[0028] At the same time, the present invention also proposes an application of the cordycepin tablets described above in the preparation of sports nutrition food resistant to hypoxia.

[0029] In the present invention, by using cordycepin tablets in the preparation of sports nutrition foods for relieving physical fatigue, or in the preparation of sports nutrition foods for resistant to hypoxia, it can increase the user's liver glycogen storage capacity, reduce amino acid decomposition metabolites, and accelerate the clearance and metabolism rate of lactic acid during exercise recovery, thereby improving post-exercise fatigue and hypoxia problems. DETAILED DESCRIPTION

[0030] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0031] The present invention will be described in detail below with reference to embodiments.

[0032] The present invention relates to a cordycepin tablet. In terms of overall design, the raw materials of the cordycepin tablet include D-mannitol, cordycepin extract, maltodextrin, a compound nutritional enhancer, and magnesium stearate. As a further preferred embodiment, the weight portions of the above raw materials are: 30-50 parts of D-mannitol, 10-35 parts of cordycepin extract, 8-28 parts of maltodextrin, 7-14 parts of a compound nutritional enhancer, and 1-2 parts of magnesium stearate. Among them, the compound nutritional enhancer consists of maltodextrin, thiamine nitrate, riboflavin and pyridoxine hydrochloride.

[0033] In the formula of the cordycepin tablets of the present invention, D-mannitol has multiple physiological effects, such as promoting immune system regulation, promoting wound healing, inhibiting the survival of cancer cells and the growth of tumors, preventing urinary tract bacterial infection, and having anti-inflammatory effects. In the formula of the cordycepin tablets, D-mannitol mainly acts as an excipient. In specific implementation, the weight percentage of D-mannitol can be set to, for example, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.

[0034] In the formula of the cordycepin tablet of the present invention, cordycepin extract, also known as Cordyceps militaris extract and cordycepin purified material, is a substance purified from Cordyceps militaris rich in cordycepin using modern processing technology, and the purpose is to extract raw materials with higher purity and content of cordycepin, and to make other products containing cordycepin ingredients. Cordycepin, as the main active substance of Cordyceps militaris, has the effects of regulating the immune function of the body, improving the comprehensive disease resistance of the body, antibacterial and anti-inflammatory, and inhibiting the proliferation of cancer cells. And cordycepin also helps to improve physical strength and endurance, and enhances the body's anti-fatigue ability. When specifically implemented, the weight percentage of the cordycepin extract can be set to 10 parts, 15 parts, 20 parts, 25 parts or 30 parts, etc.

[0035] In the formula of the cordycepin tablet of the present invention, the compound nutritional enhancer is a commercially available vitamin premix, which is composed of maltodextrin, thiamine nitrate (vitamin B1), riboflavin (vitamin B2), and pyridoxine hydrochloride (vitamin B6). Wherein, maltodextrin is used as an auxiliary material to play a filling role. The contents of thiamine nitrate, riboflavin, and pyridoxine hydrochloride in the compound nutritional enhancer are 105 mg / 100 g, 55 mg / 100 g, and 55 mg / 100 g, respectively.

[0036] Among them, thiamine nitrate can promote the aerobic metabolism of glycogen, improve exercise endurance and exercise capacity, and accelerate the elimination of lactic acid in the body, reduce the soreness after exercise, and promote fatigue recovery. Riboflavin participates in the formation of various respiratory enzymes in the body, indirectly eliminates superoxide free radicals, thereby promoting aerobic energy supply in the body, delaying fatigue, and improving exercise endurance and exercise level. Pyridoxine hydrochloride participates in the metabolism of amino acids and the synthesis of heme cofactors, promotes the conversion of cholesterol, and can effectively prevent the occurrence of atherosclerosis and anemia. It can also delay sports fatigue and improve athletes' athletic ability by promoting the production of hemoglobin and gluconeogenesis, reducing lactic acid production and other biochemical pathways.

[0037] And in specific implementation, the weight percentage of the compound nutritional enhancer can be set to, for example, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts.

[0038] In the formula of the cordycepin tablet of the present invention, maltodextrin provides carbohydrates, which helps to maintain blood sugar stability. In the formula of the cordycepin tablet, maltodextrin plays the role of a filler, a binder, a fluidity regulator, a water absorption regulator, a thermal stability enhancer, etc. In a specific implementation, the weight percentage of maltodextrin can be set to, for example, 8 parts, 10 parts, 15 parts, 17 parts, 20 parts, 23 parts, 25 parts or 28 parts.

[0039] In the formula of the cordycepin tablets of the present invention, magnesium stearate is used as a processing glidant, which is a hydrophobic lubricant and can be effectively mixed with the particles. The tablets added with magnesium stearate can make the tablets look smoother and more beautiful after tabletting. In the specific implementation, the weight percentage of magnesium stearate can be set to 1 part, 1.5 parts or 2 parts, for example.

[0040] The cordycepin tablets of the present invention, as a sports nutrition food, can significantly increase the liver glycogen storage capacity, reduce amino acid decomposition metabolites, and accelerate the clearance and metabolism rate of lactic acid during the recovery period of exercise by using 30-50 parts by weight of D-mannitol, 10-35 parts of cordycepin extract, 8-28 parts of maltodextrin, and 7-14 parts of a compound nutrition enhancer.

[0041] Moreover, the compound nutritional enhancer in the product formula contains vitamin B1, vitamin B2 and vitamin B6, which have the effects of anti-fatigue and improving body endurance. They work synergistically with cordycepin, which has multiple functions, to enhance the body's immunity and relieve fatigue, thereby improving the problems of fatigue and hypoxia after exercise.

[0042] In addition, this embodiment also relates to a method for preparing a cordycepin tablet, which is used to prepare the above cordycepin tablet, and the preparation method comprises the following steps:

[0043] Step S1, weighing D-mannitol, cordycepin extract, compound nutrient enhancer, and maltodextrin according to weight proportions, and mixing the weighed raw materials to obtain a premix.

[0044] In step S1, the particle size of D-mannitol is not greater than 40 mesh. In the specific implementation, for example, D-mannitol is sieved. Preferably, a 40-mesh sieve is used to sieve out D-mannitol with a particle size of not greater than 40 mesh for standby use.

[0045] During the specific preparation, the D-mannitol with a particle size of no more than 40 mesh after sieving, the cordycepin extract, the compound nutritional enhancer, and the maltodextrin are weighed according to the weight proportions, and the weighed raw materials are mixed for 3 to 5 minutes to obtain a premix.

[0046] Step S2, adding a certain amount of binder to the premix, stirring evenly to obtain granulated material, and preparing wet granules from the granulated material.

[0047] Wherein, as a preferred embodiment, the binder in step S2 is 85% ethanol. Moreover, the weight ratio of ethanol to the granulation material is 32%-40%. In specific implementation, the weight ratio of ethanol to the granulation material can be set to 32%, 34%, 36%, 38% or 40%, etc.

[0048] Step S3, drying the wet particles to obtain dried premix particles. Preferably, the moisture content of the dried premix particles is not more than 7.5%. In the specific preparation, for example, the wet particles prepared in step S2 are placed in an oven for drying until the moisture content of the wet particles is not more than 7.5%. Preferably, in step S3, the temperature of the oven is preferably set to 50°C, so that the wet particles can be dried well and the drying time can be set.

[0049] Step S4, mixing the premix particles with magnesium stearate to obtain a total mixed powder. Wherein, before mixing the premix particles with magnesium stearate, the preparation method of the cordycepin tablets of this embodiment also includes sieving and granulating the premix particles. During the specific preparation, the premix particles dried in step S3 are sieved through a 20-mesh sieve to obtain dried premix particles with a particle size not greater than 20 mesh. Then, the premix particles with a particle size not greater than 20 mesh are mixed with magnesium stearate. For example, the premix particles dried in step S4 and magnesium stearate are put into a mixer and mixed for a certain time, for example, for 20 minutes, and the total mixed powder is obtained after mixing evenly.

[0050] Step S5, compressing the total mixed powder into tablets according to a preset weight to obtain cordycepin tablets. In the specific preparation, the total mixed powder is loaded into a tablet press and compressed into tablets according to a preset weight to obtain sheet-shaped cordycepin tablets. The preset weight is 0.49 g / tablet, and the weight difference is within ±5%, that is, the weight of each cordycepin tablet is between 0.4655 g and 0.5145 g.

[0051] In this embodiment, after the total mixed powder is compressed into tablets according to a preset weight to obtain cordycepin tablets, that is, after step S5, the method for preparing cordycepin tablets further includes: coating the cordycepin tablets.

[0052] During the coating process, a commercially available compound thickener is used, for example, a compound thickener sold by Netanya (Beijing) Health Technology Development Co., Ltd. is dissolved in purified water to form a porridge-like liquid, and then the cordycepin tablets are immersed in the porridge-like liquid so that the surface of the cordycepin tablets is evenly coated with a layer of the compound thickener.

[0053] This not only protects the cordycepin tablets from the influence of moisture, oxygen and other factors in the air, thereby increasing the stability of the tablets, but also controls the release rate of the drug in the body, allowing it to be released slowly over a specific period of time, thereby improving the efficacy of the drug. At the same time, it can also make the appearance of the tablets more beautiful and increase patient acceptance, effectively isolate external pollutants such as dust and bacteria, and ensure the hygiene and safety of the drugs.

[0054] In specific implementation, the coating weight gain of cordycepin tablets is 3%. Wherein, coating weight gain = (average weight after coating - average weight of plain tablets) / average weight of plain tablets. The limitation on coating weight gain here is conducive to ensuring the quality of cordycepin tablets.

[0055] The cordycepin tablets and the preparation method thereof of the present invention are described in detail below through specific preparation examples.

[0056] Preparation Example 1

[0057] A cordycepin tablet comprises the following raw materials in parts by weight: 40 parts of D-mannitol, 30 parts of cordycepin extract, 10 parts of maltodextrin, 7 parts of a compound nutritional enhancer and 1 part of magnesium stearate.

[0058] The preparation method of cordycepin tablets in this preparation example specifically adopts the following production process: raw materials → screening → weighing → premixing and granulating of part of the raw materials → drying → granulation → total mixing → tableting → coating.

[0059] Specifically, first, D-mannitol is passed through a 40-mesh sieve, and D-mannitol with a particle size of no more than 40 mesh is taken for standby use. Then, D-mannitol with a particle size of no more than 40 mesh, cordycepin extract, compound nutritional enhancer, and maltodextrin are weighed. Then, the above raw materials are pre-mixed according to a preset weight portion, mixed for 3 to 5 minutes, and then 85% ethanol is added, wherein the amount of 85% ethanol accounts for 36% of the total amount of granulation materials, and after stirring evenly, granulation is performed through a 20-mesh sieve to form wet granules.

[0060] Then, the wet granules are placed in a 50°C oven and dried until the moisture content is no more than 7.5%. The dried granules are then sieved through a 20-mesh sieve to obtain dry granules with a particle size of less than or equal to 20 mesh. Then, the dry granules and a certain amount of magnesium stearate are put into a mixer and mixed for 20 minutes to obtain a total mixed powder. The total mixed powder is then loaded into a tablet press and tableted according to a preset weight.

[0061] The compressed cordycepin tablets are regularly inspected, and the weight of each cordycepin tablet is 0.49 g / tablet, and the weight difference limit is ±5%. The cordycepin tablets are then coated. During the coating, the compound thickener is dissolved in purified water to form a porridge-like liquid, and then the cordycepin tablets are soaked in the porridge-like liquid, so that the surface of the cordycepin tablets is evenly coated with a layer of compound thickener. Among them, the coating weight increases by 3%, and the surface of the cordycepin tablets is evenly coated with a layer of compound thickener.

[0062] Preparation Example 2

[0063] The difference between this preparation example and preparation 1 is only the amount of each component used. The details are as follows:

[0064] A cordycepin tablet comprises the following raw materials in parts by weight: 50 parts of D-mannitol, 35 parts of cordycepin extract, 25 parts of maltodextrin, 10 parts of a compound nutritional enhancer and 2 parts of magnesium stearate.

[0065] The preparation method of the cordycepin tablets in this preparation example is the same as that in Preparation Example 1.

[0066] Preparation Example 3

[0067] The difference between this preparation example and preparation example 1 is only the amount of each component used. The details are as follows:

[0068] A cordycepin tablet comprises the following raw materials in parts by weight: 44 parts of D-mannitol, 27 parts of cordycepin extract, 18 parts of maltodextrin, 10 parts of a compound nutritional enhancer and 1 part of magnesium stearate.

[0069] The preparation method of the cordycepin tablets in this preparation example is the same as that in Preparation Example 1.

[0070] Preparation Example 4

[0071] The difference between this preparation example and preparation example 1 is only the amount of each component used. The details are as follows:

[0072] A cordycepin tablet comprises the following raw materials in parts by weight: 45 parts of D-mannitol, 30 parts of cordycepin extract, 20 parts of maltodextrin, 10 parts of a compound nutritional enhancer and 2 parts of magnesium stearate.

[0073] The preparation method of the cordycepin tablets in this preparation example is the same as that in Preparation Example 1.

[0074] Preparation Example 5

[0075] The difference between this preparation example and preparation example 1 is only the amount of each component used. The details are as follows:

[0076] A cordycepin tablet comprises the following raw materials in parts by weight: 44 parts of D-mannitol, 25 parts of cordycepin extract, 15 parts of maltodextrin, 10 parts of a compound nutritional enhancer and 1 part of magnesium stearate.

[0077] The preparation method of the cordycepin tablets in this preparation example is the same as that in Preparation Example 1.

[0078] Preparation Example 6

[0079] The difference between this preparation example and preparation example 1 is only the amount of each component used. The details are as follows:

[0080] A cordycepin tablet comprises the following raw materials in parts by weight: 40 parts of D-mannitol, 20 parts of cordycepin extract, 25 parts of maltodextrin, 14 parts of a compound nutritional enhancer and 1 part of magnesium stearate.

[0081] The preparation method of the cordycepin tablets in this preparation example is the same as that in Preparation Example 1.

[0082] Comparative Example 1

[0083] A nutritional tablet comprises the following raw materials in parts by weight: 40 parts of D-mannitol, 25 parts of maltodextrin, 14 parts of a compound nutritional enhancer and 1 part of magnesium stearate.

[0084] The preparation method of the nutritional tablet of this comparative example is as follows:

[0085] First, pass D-mannitol through a 40-mesh sieve, and take D-mannitol with a particle size of no more than 40 mesh for standby use. Then weigh D-mannitol with a particle size of no more than 40 mesh, as well as compound nutritional enhancers and maltodextrin. Then pre-mix the above raw materials according to the preset weight portions, mix for 3 to 5 minutes, and then add 85% ethanol, wherein the amount of 85% ethanol accounts for 36% of the total amount of granulation materials, stir evenly, and granulate through a 20-mesh sieve to form wet granules.

[0086] Then, the wet granules are placed in a 50°C oven and dried until the moisture content is no more than 7.5%. The dried granules are then sieved through a 20-mesh sieve to obtain dry granules with a particle size of less than or equal to 20 mesh. Then, the dry granules and a certain amount of magnesium stearate are put into a mixer and mixed for 20 minutes to obtain a total mixed powder. The total mixed powder is then loaded into a tablet press and tableted according to a preset weight.

[0087] The tablets pressed into sheets are regularly inspected, and the weight of each tablet is 0.49g / tablet, and the weight difference limit is ±5%. The tablets are then coated. During the coating, the compound thickener is dissolved in purified water to form a porridge-like liquid, and then the tablets are soaked in the porridge-like liquid so that the surface of the tablets is evenly coated with a layer of compound thickener. Among them, the coating increases weight by 3%, and the surface of the tablets is evenly coated with a layer of compound thickener.

[0088] Comparative Example 2

[0089] A nutritional tablet comprises the following raw materials in parts by weight: 45 parts of D-mannitol, 30 parts of cordycepin extract, 22 parts of maltodextrin and 2 parts of magnesium stearate.

[0090] The preparation method of the nutritional tablet of this comparative example is as follows:

[0091] A nutritional tablet comprises the following raw materials in parts by weight: 45 parts of D-mannitol, 30 parts of cordycepin extract, 22 parts of maltodextrin and 2 parts of magnesium stearate.

[0092] The preparation method of the nutritional tablet is as follows:

[0093] First, pass D-mannitol through a 40-mesh sieve, and take D-mannitol with a particle size of no more than 40 mesh for standby use. Then weigh D-mannitol with a particle size of no more than 40 mesh, cordycepin extract, and maltodextrin. Then pre-mix the above raw materials according to the preset weight portions, mix for 3 to 5 minutes, and then add 85% ethanol, wherein the amount of 85% ethanol accounts for 36% of the total amount of granulation materials, stir evenly, and granulate through a 20-mesh sieve to form wet granules.

[0094] Then, the wet granules are placed in a 50°C oven and dried until the moisture content is no more than 7.5%. The dried granules are then sieved through a 20-mesh sieve to obtain dry granules with a particle size of less than or equal to 20 mesh. Then, the dry granules and a certain amount of magnesium stearate are put into a mixer and mixed for 20 minutes to obtain a total mixed powder. The total mixed powder is then loaded into a tablet press and tableted according to a preset weight.

[0095] The tablets pressed into sheets are regularly inspected, and the weight of each tablet is 0.49g / tablet, and the weight difference limit is ±5%. The tablets are then coated. During the coating, the compound thickener is dissolved in purified water to form a porridge-like liquid, and then the tablets are soaked in the porridge-like liquid so that the surface of the tablets is evenly coated with a layer of compound thickener. Among them, the coating increases weight by 3%, and the surface of the tablets is evenly coated with a layer of compound thickener.

[0096] The anti-fatigue ability of the cordycepin tablets of the present invention was evaluated as follows.

[0097] The present invention explains in detail the anti-fatigue effect of cordycepin tablets on mice and its anti-fatigue mechanism through a classic weighted swimming experiment and determination of weighted swimming time, liver glycogen content, serum urea content, blood lactate level and other indicators.

[0098] Weighted swimming test method:

[0099] A lead sheet weighing 5% of the body weight was fixed to the tail of the mouse, and the mouse was made to swim in a swimming box with a water depth of 35 cm and a water temperature of 25°C, and the swimming time was recorded.

[0100] Glycogen determination method:

[0101] Weigh 100 mg of mouse liver that had been rinsed and dried with filter paper, add 8 mL of trichloroacetic acid for homogenization, centrifuge the homogenate at 3000 r / min for 15 min, and take the supernatant to measure the liver glycogen content by the anthrone method.

[0102] Serum urea determination method:

[0103] In a swimming box with a water depth of 30 cm and a water temperature of 30°C, the mice were allowed to swim for 90 min and then rest for 60 min. Blood was collected to measure the serum urea content.

[0104] Blood lactate determination method:

[0105] Before swimming, 20 μL of blood was collected from the inner canthus of each group of mice, and then they were placed in a swimming box with a water depth of 30 cm and a water temperature of 30°C to swim for 10 min. 20 μL of blood was collected at 0 min and 20 min after swimming, and the blood lactate content at the three time points was measured using a lactate analyzer.

[0106] Trial Groups:

[0107] Male BALB / c mice were divided into four batches, 72 in each batch, and each batch of animals was randomly divided into solvent control group, comparative example 1 group, comparative example 2 group, low, medium and high dose groups according to body weight, 12 in each group. The test substance was prepared according to 5 times, 10 times and 20 times of the recommended amount for the human body, that is, 0.25g / kg, 0.50g / kg, 1.00g / kg were used as low, medium and high dose groups, distilled water was used as solvent control group, and the nutritional tablets in comparative example 1 and comparative example 2 were prepared according to 20 times of the test substance as comparative example 1 group and comparative example 2 group, respectively, and the weight-bearing swimming time (a batch of mice), liver glycogen content (two batches of mice), urea content (three batches of mice) and lactic acid level (four batches of mice) of mice were measured. The gavage volume was 20mL / kg, once a day, for 30 consecutive days. Each index was measured 30min after the last gavage.

[0108] Weighted swimming time: Comparison of weighted swimming time of mice between the solvent control group and the cordycepin tablets at each dose group. Compared with the solvent control group, the weighted swimming time of mice in the comparative example 1 group and the comparative example 2 group was basically not increased or increased insignificantly, while the weighted swimming time of mice in the cordycepin tablets low, medium, and high dose groups was significantly increased. The experimental results are shown in Table 1.

[0109] Table 1 Results of weight-bearing swimming time measurement in mice

[0110] Group Number of mice Weighted swimming time (min) Solvent control group 12 7.55±0.46 Comparative Example 1 12 7.56±0.51 Comparative Example 2 12 7.61±0.42 Low dose group 12 8.11±0.52 Medium dose group 12 8.73±0.61 High dose group 12 9.25±0.88

[0111] Glycogen content determination: Comparison of liver glycogen content in mice between the solvent control group and the cordycepin tablets at each dose group. Compared with the solvent control group, the liver glycogen content in mice in the comparative example 1 group and the comparative example 2 group was basically not increased or increased insignificantly, while the liver glycogen content in mice in the cordycepin tablets at each dose group increased. The experimental results are shown in Table 2.

[0112] Table 2 Results of determination of mouse liver glycogen content

[0113]

[0114] Serum urea content determination: Comparison of serum urea content of mice between the solvent control group and the cordycepin tablets dose groups. Compared with the solvent control group, the serum urea content of mice in the comparative example 1 group and the comparative example 2 group remained basically unchanged or did not decrease significantly during exercise, while the serum urea content of mice in the cordycepin tablets low, medium and high dose groups decreased significantly during exercise. The experimental results are shown in Table 3.

[0115] Table 3 Results of serum urea content determination during exercise in mice

[0116] Group Number of mice Urea (mmol / L) Solvent control group 12 12.28±0.65 Comparative Example 1 12 12.27±0.57 Comparative Example 2 12 12.26±0.52 Low dose group 12 11.64±0.87 Medium dose group 12 11.15±0.74 High dose group 12 10.63±0.83

[0117] Post-exercise blood lactate level determination: Comparison of blood lactate content in mice between the solvent control group and the cordycepin tablets at different doses. Compared with the solvent control group, the blood lactate content in the control group 1 and control group 2 mice remained basically unchanged or did not decrease significantly during exercise, while the blood lactate content in the cordycepin tablets low, medium and high dose groups was significantly reduced. The experimental results are shown in Table 4.

[0118] Table 4 Calculation results of mouse blood lactate content Through the above experimental data, it can be found that the cordycepin tablets of the present invention can first prolong the weight-bearing swimming time of mice, indicating that cordycepin tablets can significantly enhance the sports endurance of mice. Secondly, the content of mouse liver glycogen can be increased, thereby improving the body's anaerobic and aerobic metabolic capacity, enhancing the body's tolerance during physical load, and having a good effect of relieving physical fatigue. Again, the production of serum urea in mice during exercise is reduced, which is a manifestation of its ability to increase body endurance and improve the ability to adapt to severe loads. In addition, the area under the blood lactate curve of mice can be significantly reduced, indicating that cordycepin tablets can accelerate the clearance and metabolism rate of lactic acid during exercise recovery, improve aerobic metabolic capacity, and facilitate the rapid elimination of fatigue.

[0119] At the same time, the above experimental data can also clearly show that cordycepin tablets containing compound nutritional enhancers and cordycepin extracts, as well as D-mannitol, maltodextrin, and magnesium stearate, can enhance the body's immunity and relieve fatigue by utilizing the synergistic effect of cordycepin in the specific vitamin ratio in the compound nutritional enhancers, thereby improving the problems of fatigue and hypoxia after exercise.

[0120] In summary, cordycepin tablets can show a good effect in relieving physical fatigue by increasing liver glycogen storage capacity, reducing amino acid decomposition metabolites, and accelerating the clearance and metabolism of lactic acid during exercise recovery.

[0121] In addition, the present invention also relates to an application of the cordycepin tablets in preparing sports nutrition food for relieving physical fatigue.

[0122] Meanwhile, the present invention also relates to an application of the cordycepin tablets, that is, the application of the cordycepin tablets in preparing sports nutrition food resistant to hypoxia.

[0123] In the present invention, by using cordycepin tablets in the preparation of sports nutrition foods for relieving physical fatigue, or in the preparation of sports nutrition foods for resistant to hypoxia, it can increase the user's liver glycogen storage capacity, reduce amino acid decomposition metabolites, and accelerate the clearance and metabolism rate of lactic acid during exercise recovery, thereby improving post-exercise fatigue and hypoxia problems.

[0124] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A cordycepin tablet, characterized in that: The raw materials of the cordycepin tablets include D-mannitol, cordycepin extract, maltodextrin, a compound nutritional enhancer and magnesium stearate.

2. The cordycepin tablet according to claim 1, characterized in that The weight parts of each raw material are respectively: 30-50 parts of D-mannitol, 10-35 parts of cordycepin extract, 8-28 parts of maltodextrin, 7-14 parts of compound nutritional enhancer, and 1-2 parts of magnesium stearate.

3. A method for preparing cordycepin tablets, characterized in that: The preparation method is used to prepare the cordycepin tablets according to claim 1 or 2, and the preparation method comprises: Weigh D-mannitol, cordycepin extract, compound nutrient enhancer, and maltodextrin according to weight proportions, and mix the weighed raw materials to obtain a premix; Adding a binder to the premix, stirring evenly to obtain a granulated material, and preparing the granulated material into wet granules; Drying the wet granules to obtain dry premix granules; Mixing the premix particles with magnesium stearate to obtain a total mixed powder; The total mixed powder is tableted according to a preset weight to prepare cordycepin tablets.

4. The method for preparing cordycepin tablets according to claim 3, characterized in that: The particle size of the D-mannitol is no more than 40 meshes.

5. The method for preparing cordycepin tablets according to claim 3, characterized in that: The adhesive is 85% ethanol; and / or, The weight ratio of the binder to the granulating material is between 32% and 40%.

6. The method for preparing cordycepin tablets according to claim 3, characterized in that: The moisture content of the premix particles after drying is not more than 7.5%, and / or, The preset weight is 0.49 g / tablet, and the weight difference limit is required to be ±5%.

7. The method for preparing cordycepin tablets according to claim 3, characterized in that: Before mixing the premix with magnesium stearate, the preparation method further comprises: The premix granules are sieved and sized.

8. The method for preparing cordycepin tablets according to claim 3, characterized in that: After the total mixed powder is compressed into tablets according to a preset weight to obtain cordycepin tablets, the preparation method further comprises: coating the cordycepin tablets.

9. Use of the cordycepin tablets according to claim 1 or 2 in preparing sports nutrition food for relieving physical fatigue.

10. Use of the cordycepin tablets according to claim 1 or 2 in preparing sports nutrition food resistant to hypoxia.

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